<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE07</accession>
    <name>W4TE07_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pfp</name>
        <name evidence="10" type="ORF">JCM18909_238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'P' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67195">
        <property type="protein sequence ID" value="GAE67195"/>
        <property type="gene ID" value="JCM18909_238"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01977">
        <property type="entry name" value="Phosphofructokinase_II_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011405">
        <property type="entry name" value="PPi-PFK_SMc01852"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036484">
        <property type="entry name" value="PPi-PFK_SMc01852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="325"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="400" mass="43095" checksum="0BB9288AC630A4BA" modified="2014-03-19" version="1">MAVKKVALLTAGGFAPCLSTAISGLIQRYTEVAPEVEIIAYKHGYEGLLKGDFLEVTDTVRKNAEILKRFGGSPIGNSRVKLTNAADLVKRGLVAEGDDPLKVAADRLVADGVDILHTIGGDDTNTTAADLAAYLAENNYGLTVVGLPKTIDNDVVPIRQSLGAWTAAEQGSRFAQNIVGEHNSGSRMLIVHEVMGRNCGWLTAATAAKYREWLDTQQWLPEIGLSKKAWDVHAVYVPEAHIDLEAEAARLNKVMDEVGNVTIFLSEGAGLDAIIEEMEKKDGQEVPRDPFGHVKLDKVNSGAWFGKQFADKLGAEKFMVQKSGYFSRSAASNEADLELIGRCTDLAVDCALAGKTGVIGQDEENGDTLTNIAFDRIKGGKPFDTTQPWFTAMLSEIGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE31</accession>
    <name>W4TE31_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_64</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67031">
        <property type="protein sequence ID" value="GAE67031"/>
        <property type="gene ID" value="JCM18909_64"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="295" mass="32080" checksum="C1C5B8BD6F9C1D58" modified="2014-03-19" version="1">MLVIAAGYTIFAILTAISPSAGLFLAMRVLLGITIGLSITVVPVFIAESAPASRRGGLATAYQVTCVVGIILGYLVGYSLLPTDTWRWILGVAAVPAFVVLLMLVRTQETPSWYMLKGREDEARRAMERIEVAELVEPSLDEIRNSLSSRPSGSVWGRLREMFYGGMARATIFAIVLGFSIQITGINATIYYAPGIYSRMGFTDTATTYLVPSLVQFLSLISVVISMLVIDKVGRRFVLITGISTMIVATIVLIVTYLASGFEGAVAGVIGLVGMSLFYYGVYLRFRFHRMGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE36</accession>
    <name>W4TE36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_70</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67036">
        <property type="protein sequence ID" value="GAE67036"/>
        <property type="gene ID" value="JCM18909_70"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDH_E1_M" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7617" checksum="90241BDC6AAB006E" modified="2014-03-19" version="1">MTKGFIIGATAGRTTLTGEGTQHMDGHSPVLAATNPAVISYDPAYSYEISTLFRQDWSTCTARMPKTSCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE89</accession>
    <name>W4TE89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67101">
        <property type="protein sequence ID" value="GAE67101"/>
        <property type="gene ID" value="JCM18909_138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_NTP_bind" evidence="2">
        <location>
            <begin position="185"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3418" evidence="3">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="326" mass="36647" checksum="E4DE7B27FFB5ACE4" modified="2014-03-19" version="1">MLLEGARQGSLAEVLVIVAALSIRDVRERPADKREEADAFHRRFATEANLLQTLQAADNTDNNRVGDWSQVRRQHIHQEAANTAKPGLPARHTPHTKGKISPRPQTGGIDEGGDIMAIHRLWRYLRHQRRHMGSSAFRRMCRAEYINYLRVREWDDLHGQLRQIAKELHLEVNHTSAPTDRVLVALLSGLLSHIGLVQVRQSVKRHGQRPGPQEYLGARGTKFAINPGSLLARKSPELVVAVELVETSRLWARTVAAVQPEWVEEVAGPLIRRSWAVPHWAASTASVVATERGTLFGVPLWADRRVTYGRIDPVASRQIFLSVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEQ8</accession>
    <name>W4TEQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_42</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67012">
        <property type="protein sequence ID" value="GAE67012"/>
        <property type="gene ID" value="JCM18909_42"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="4925" checksum="6BD7E853A7334A08" modified="2014-03-19" version="1">MIALIATDLDGTFLGADKLPSAENTEPCSLLQMPAYTSSSPPDVLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF18</accession>
    <name>W4TF18_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH HARE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67381">
        <property type="protein sequence ID" value="GAE67381"/>
        <property type="gene ID" value="JCM18909_437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="253" mass="28166" checksum="CFA78C476B576F67" modified="2014-03-19" version="1">MLSEAKEPLHYSEIAQRILDSGLHQQTGATPAATVAAAISTTLRKNVVRVDRGVYSLRTPQSVPAEESETELPDSRGVIPLTALEAGEENNGFLNAFGMFWRRDEVDWDKRGQTLLGAQLKAAKPVNFADQVGVYILYSGERVICVGRITEPRLGPRLWDHTRDRLAGRWDRFSWFGVRTADDDGTLGPVPSGNFAVDMLVSTMEALLIEGLEPPQNRRRGDGFNATEFIQATDPEVERRRAKQLLFKLTDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF62</accession>
    <name>W4TF62_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Holo-[acyl-carrier protein] synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67605">
        <property type="protein sequence ID" value="GAE67605"/>
        <property type="gene ID" value="JCM18909_678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="47" mass="5067" checksum="EBBF19CB3F9EDC01" modified="2014-03-19" version="1">MVTDGEAVKFELRGSLARRAEELGVRRVHLSLTHDAGVAVAMVVCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFE8</accession>
    <name>W4TFE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67158">
        <property type="protein sequence ID" value="GAE67158"/>
        <property type="gene ID" value="JCM18909_200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013559">
        <property type="entry name" value="YheO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08348">
        <property type="entry name" value="PAS_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS_6" evidence="1">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_22" evidence="2">
        <location>
            <begin position="158"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25530" checksum="BDD5AAEEE61256C6" modified="2014-03-19" version="1">MNHISRASREAMITALAGLVDPLKRSLIGSSEVVLHDLSKMPNSIVAISGHLTSRNIGDPATEALLRAWREGTMQTRIGYESTSPEGRALRSSTILIEDADGPFAALCTNTDVSVWQGVHDMTAAILHGGPWPGETPAPQIPRHQDPPRDIKQVAAGLMREAIDQVGVPVSLMRKDHKLRVVDELRRRGFFLLKDSIEATANRLKVSRFTVYNYLNELDERGDADTDDSGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFH8</accession>
    <name>W4TFH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67188">
        <property type="protein sequence ID" value="GAE67188"/>
        <property type="gene ID" value="JCM18909_231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="94"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19051" checksum="D763A110DBD9BD10" modified="2014-03-19" version="1">MNKCPMCGHVSEDGANFCSRCGTRLGVPIDTPGDNTGVIPTITEPTVAEETPPNVDLPAGVLQDIADLPAENAMLIVRRGPNLGAQFLLDQDETTAGRSTHSDIFLDDITVSRHHVKFIRQDGQMVIEDQGSLNGTYVNRTLVDGSAVLRDGDEVQIGKFRMTYHTGGTASGTSGAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFN5</accession>
    <name>W4TFN5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67785">
        <property type="protein sequence ID" value="GAE67785"/>
        <property type="gene ID" value="JCM18909_868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9934" checksum="B0F2E8ABCFE36633" modified="2014-03-19" version="1">MVMQDVRRQLFSESVEREVTLGLDLPHRDAADVPGLLERLDLAGERDRHPLSLSGGQAQRLVVAATIAQDKEVVVFDEPTSGVDRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFP2</accession>
    <name>W4TFP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67347">
        <property type="protein sequence ID" value="GAE67347"/>
        <property type="gene ID" value="JCM18909_396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="1">
        <location>
            <begin position="107"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="315" mass="35144" checksum="D86BACD81809D190" modified="2014-03-19" version="1">MFKKDGAGKKLIKQFCTPATPSILNGGKWRNLPSADPTGWARFIDYNRRDVEVELAIHNRLASFPMPKVEWETYALDQTINDDGILLDHTLVDNAVTVNERHRNATLARAQALTGLDNPNSPIQLKQWLATRGCELESLTKADVGTALDTATGEVKEVFELRGDLAKSSVKKYQAMQNVAGRDGRARGLIQFYGAGRTGRFAGHLVQVQNLPRNYLPDLNHARALVKMGDLDALDLLYDSIPDTLSQLIRTAFIPSPGHRFIVADFSAIEARVVAWFAGEHATLQAFREGKDLYCETASQMHRQLHNRLPIEIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFQ5</accession>
    <name>W4TFQ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67268">
        <property type="protein sequence ID" value="GAE67268"/>
        <property type="gene ID" value="JCM18909_314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14598" checksum="C2BCECE443B774B6" modified="2014-03-19" version="1">MYSTNTVEIVSNDRGHVKTVRVVSGHRDENRVFIADEGSEHDLPADLVIFAMGFAHPEYDGVVAELGLELDGRGNIVRMMRMRLMCRGFSPAVTLAAGSPLWCGPSRRDAQLLTVLMHISKDHRRCYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT8</accession>
    <name>W4TFT8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67392">
        <property type="protein sequence ID" value="GAE67392"/>
        <property type="gene ID" value="JCM18909_449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10599" checksum="EC6080AF90003BE9" modified="2014-03-19" version="1">MIKGETYENGPRSQRVRDAVVATVATLYGIWLVVAAGADALMLAALLYLPGAAVFVWAKREQRAKRIFKPYEIGVLVLLALISVVAIISIVTGRLSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFU3</accession>
    <name>W4TFU3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67840">
        <property type="protein sequence ID" value="GAE67840"/>
        <property type="gene ID" value="JCM18909_927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7750" checksum="3B9399C914025D23" modified="2014-03-19" version="1">MSKDAHELIDMATDFMNRRPQLSRGGHFEILEHDALAAFSTTGLPAATGMTFLTRGNIARDVAGSASKSADVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV6</accession>
    <name>W4TFV6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67318">
        <property type="protein sequence ID" value="GAE67318"/>
        <property type="gene ID" value="JCM18909_365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="246" mass="26809" checksum="97F3DADB36D56B5D" modified="2014-03-19" version="1">MNTFGSLSGKMGLMSHAQAPQSFGRVDDDGTVYVRTSDGERSVGQVPDSTSEEALEFFVRRYRALETEVSLLESRVSSGTASPEEARSAASKLVTSIHEANAVGDLESLAARVEALTPTIDAKAETRREERAEAKARAKQAKEEMVAQAEAIAAGSDWRGGIGKFRDLLDQWRRLPRIDKTIDDELWHRFFPVLAPHLPVVASSTWLSRTTCASAPASSRSTSLRRLVRWPSRPPGARPLASSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX3</accession>
    <name>W4TFX3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neopullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67407">
        <property type="protein sequence ID" value="GAE67407"/>
        <property type="gene ID" value="JCM18909_465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24885" checksum="6BD0FBE3154343E4" modified="2014-03-19" version="1">MSHRLAHLEAWLDHAVALGCSGLALGPVFSSASHGYDTLDYFTIDPRLGDDDDFDHLLQAAHARGLSVLLDGVFNHVSRRNRIVQDAQSAGPDSDAGRMVRWCAGHFDVFEGHSDLVALNHDNPAVREHVTRIMNYWCGRGVDGWRLDAAYSVNPEFWAAVLPPVREKHPDVWIFGEVIHGDYAGIVRASGMDSVTQYELWKGIWSSIESRNFFRARSCFGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ9</accession>
    <name>W4TFZ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67358">
        <property type="protein sequence ID" value="GAE67358"/>
        <property type="gene ID" value="JCM18909_408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RuvB_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9829" checksum="F3479433E5F64D74" modified="2014-03-19" version="1">MEISAVTAGVKDIRRELDTARRQLALGQPTVLFVDEVHRFSKAQQDVLLPAVENRTVTLIAATTENPSFFGHLPAVVALLIVDPQATHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG40</accession>
    <name>W4TG40_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin-antitoxin system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67492">
        <property type="protein sequence ID" value="GAE67492"/>
        <property type="gene ID" value="JCM18909_554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7303" checksum="62C24B5C3DBFE02B" modified="2014-03-19" version="1">MVKPMKYRKLVGLLREAGFTPTQGKGDHEKWRNGTTWTIITQTTECSPKVVKDALDAIERSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB3</accession>
    <name>W4TGB3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67448">
        <property type="protein sequence ID" value="GAE67448"/>
        <property type="gene ID" value="JCM18909_509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="11818" checksum="777E90C04757511C" modified="2014-03-19" version="1">MSGDGAGAATTLNAAGSAWSEHAGGTSGALWGAVLTAFGAVLGDEDPAGEDTIRRASRTALDAVTRLGGASVGDKTMVDAMDPSSRPSSPRLIRCRRCGNQPVTLPTWQLRRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB5</accession>
    <name>W4TGB5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate, phosphate dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67831">
        <property type="protein sequence ID" value="GAE67831"/>
        <property type="gene ID" value="JCM18909_918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="52"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="300"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="420"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="575" mass="62515" checksum="C56538DF392CB8A8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD3</accession>
    <name>W4TGD3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67846">
        <property type="protein sequence ID" value="GAE67846"/>
        <property type="gene ID" value="JCM18909_936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9605" checksum="A6C3093AF391C25A" modified="2014-03-19" version="1">MFWDYIPLSDFDSTLDPESPTLKLALADFFHEVEFTTLNRRSSGGIPTHRKPRQDILEQPRPAKKKRRTANRPAASALHVSGNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH3</accession>
    <name>W4TGH3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67632">
        <property type="protein sequence ID" value="GAE67632"/>
        <property type="gene ID" value="JCM18909_705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20774" checksum="F1148E6D62D18976" modified="2014-03-19" version="1">MAVTTYENRSRFTQRLQSRGTKNTTSGGDPSRRSAGWYIHHFIGSAFQLGAMATTYYASRTEPLNWDAHTNISWALLFIAIIVIPSLLTFVESFVEPDGSGQDVVAGVTIMLALGGIITMGVLADTPIVTTPVPFSILLPVSLALTAIAPCSLPGSNPRADSMFTETHYGAWSSRWVAPVVCLILWIIRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY3</accession>
    <name>W4TGY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NLP/P60-family secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68225">
        <property type="protein sequence ID" value="GAE68225"/>
        <property type="gene ID" value="JCM18909_1348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850747" evidence="2">
        <location>
            <begin position="34"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="190"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="271"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="388" mass="40498" checksum="292583B81E32A672" modified="2014-03-19" version="1">MGVVRPLRAGVATLATAGLAIGGSQFFVPPAQATNSSVKARVSARTAVNIRAQAGIHGKIVGVLERGQQLNQTGVPVNGWVPVAYRGHTAFIDHHYLSSVAWRPSPSSPSASSSPVGIAQATTYVYVRAGHSMQAAKVGVLSPGEKVGVTGRSAQGFSEVVYNGVHRWVGSRYLSPTAAKPSPKPAPAPKPSKTVYTTANLNLRNGASTNAAVYTSVSRGTALATTGRTTSGWTQITHRGRTLWASSKYLTTTAQPTPAPRPAPDPSVSPRGARAAIVNYATAQVGKVYIWGGEGPDGFDCSGLVLKAYQQAGINLPHYSGSQIERGHRISLDQIQPGDLFAASGGGHVGIYVGNGYMVEAANPRAGVRLSPIRSSMYPVRINSNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ0</accession>
    <name>W4TGZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dipeptide transport ATP-binding protein DppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67802">
        <property type="protein sequence ID" value="GAE67802"/>
        <property type="gene ID" value="JCM18909_887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14397" checksum="6C7BB65EFAFBD597" modified="2014-03-19" version="1">MSSGVIRRQIGWVRAVSGVSFDVYEGETLGIVGESGCGKSTLGRVITALEPATSGSVCINGKDIAQASRRERTLLHRNVQMMFQDSYAAMDPRMRVDEILSEPLSIQKNRRPAFACRRCGQSHRQDRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ6</accession>
    <name>W4TGZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isocitrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67703">
        <property type="protein sequence ID" value="GAE67703"/>
        <property type="gene ID" value="JCM18909_782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="375" mass="41215" checksum="214559DEAF9B5353" modified="2014-03-19" version="1">MWNAEGKCQETLACIPDRSYATMYAAIMDDCRAHGALDPATMGDVPNVGLMAQKAEEYGSHPTTFIVPHDGRVEVRCGDEVLTSQQVEAGDVWRMSRVRDIPVRDWVRLAVERARITNTPAVFWLDENRAHDARVIEKVKAYLPEHEGLDIRILAPADAMKFTLARIRRGEDTISVTGNVLRDYLTDLFPILEIGTSAKMLSVVPLLAGGGLFETGAGGSAPKHVAQFVAEDYLRWDSLGEFCALGACLEHIDQTSEGTKAGILAATLDKAIGAFLENDRSPARKLGQIDNRGSHYWLARYWAAELAAQHDDAELADRFSDVATELAAREDQILKELNGVQGSPVDMGGYYHPDEELVAEAMRPSTTFNAIIESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH13</accession>
    <name>W4TH13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67409">
        <property type="protein sequence ID" value="GAE67409"/>
        <property type="gene ID" value="JCM18909_467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7709" checksum="B409E0423CEB4062" modified="2014-03-19" version="1">MKRIKAKGIEVVVYEPTFDGDEFFFHSEVTKNLDFFKANCDVIIANRMSPDLSDVAGKVYTRDLFGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH52</accession>
    <name>W4TH52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YidE/YbjL duplication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAE transporter (TC 2.A.81) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67857">
        <property type="protein sequence ID" value="GAE67857"/>
        <property type="gene ID" value="JCM18909_948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006512">
        <property type="entry name" value="YidE_YbjL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06826">
        <property type="entry name" value="Asp-Al_Ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="118"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="199"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="358" mass="37646" checksum="E74A4BE2DDFAF97F" modified="2014-03-19" version="1">MIKGLGVVLFCYTVGLAAGSTFLSDLKRQWGLMLAGVVGLAAMAAAGLGLGRLFGLTPAHVAGLYAGVLTSPAIDAASTATHGAADTLVGYALSYPVGVVVGLIMVAIIAKRCWPASKDNTSMAEAGLTSVSTVVDRETSIRQTPGFNDDQIRMSYLLRDGEMRLATPDDDLHVGDQVLVVGNPDDVNRAVEHLGHVSERTLTNERNELDFRRFVVSNPALVGRTLGSIDVRGRTSGKVTRVRRGDLDMLARSDIVLQPGDRVLCVVPAHRLSDAADLFGDSEARVSQVDALSLGLGAALGLLLGALMVALPRGLQFELGTAAGPLVMGMILGSIHRTGPLRWQLPHATNAILRQLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH72</accession>
    <name>W4TH72_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68315">
        <property type="protein sequence ID" value="GAE68315"/>
        <property type="gene ID" value="JCM18909_1443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30003">
        <property type="entry name" value="PTHR30003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="507" mass="53738" checksum="BFD40E0B0E063A86" modified="2014-03-19" version="1">MVLLQTFTPSANPLGSQWLSALLAVLPVLAMLITLGALRWKAHLAGLFSWGVALIVAITAFRMPIGMAFSSSVQGFLYGLFPISWILLGAIWMYQVTVISGRFDDLRRTFFLISNDPRVLGILIAFCFGGLLEALAGFGAPVAIAAAMLIAIGFGKLRGAVTALVANTVPVAFGAVGLPVLMAAKTGGLDVAMVAPVTARVCAVLCLVVPFLMLAIMDGRKGVRECWPFGLFVGVVFGVTKVIVGGTPVYNLTEIFAAVVTVALSLLFLKVWKPKGGREAAERIGIPMDPTVETESVEAQEVDTSDLTGSRIFMALVPYILVIVVFGIVAIPTVKDSFKAADVKMAWPGLSGLMTAGGEAAAHQAYTWQWLSQPGFLLAIVAILVGFIYRVPLADVIKELWINAKKMKFSMLTIGLVVALAYVMGDSGQTLALGMFIAGAGAVYPFLAPILGWIARTSPDPIPPPTSCSLACRAVWGSRSVLGHILVWTVCGTCWLVRAHPAVSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH77</accession>
    <name>W4TH77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ClpB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67877">
        <property type="protein sequence ID" value="GAE67877"/>
        <property type="gene ID" value="JCM18909_969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="473" mass="51244" checksum="1AFA3734535E1D01" modified="2014-03-19" version="1">MDNNLTTMSRDAVTAATRHALAHGNPSVEPSHLLHALFTIPDNTVSPLVAGLGIDPQQVDAVATAAMRSLPSSTGASVAQPQLSGAFARVIADAQNRAEAMGDSFVATEHLLISLTAVPSDVQNGLAGLGLKPDSLAAAFNEGRGDRRVTSEESEGGESALAKYSVDLTERARAGKLDPVIGRDQEIRRVVQVLARRTKNNPVLIGEPGVGKTAVVEGLAQRVVAGDVPDSLKGRRVVSLDLSSMVAGAKYRGEFEERLKAVLNEIKEAEGQIITFIDELHTVVGAGASGEGAMDAGNMLKPMLARGELRMIGATTLDEYREHIEKDPALERRFQQVFVGEPSVEDTIAILRGLRERYEAHHKVRITDGALVAAASLSHRYITARQLPDKAIDLIDEAASRLRMEIDSSPEEIDTLRREVDRMKMEIFAVEKEDDPASQQRLMRLRADMADKEETCAAWSRAGRLRSWSQQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB1</accession>
    <name>W4THB1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68176">
        <property type="protein sequence ID" value="GAE68176"/>
        <property type="gene ID" value="JCM18909_1295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8424" checksum="A5B94E97E411370C" modified="2014-03-19" version="1">MNAHDFKAPTLIMHGENDGLVPSYFDVNWYNAITSKDKKIIQWHGLMHEIFNEPTKDQVIKTTIDWIDAHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB8</accession>
    <name>W4THB8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67828">
        <property type="protein sequence ID" value="GAE67828"/>
        <property type="gene ID" value="JCM18909_914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="14704" checksum="B046183C47239A0A" modified="2014-03-19" version="1">MRELAAANGVGVLHPHGALATDPPGLVVCDVDSTVTRTEAIDLLAECAGKADEVREITTRAMAGELDFAQSLYARVRCLERLHIGALEEARKATVVTPGTAELVAAAHEVGAAVGLVSGGFTALVDPLAEQIGADFAAPMSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM1</accession>
    <name>W4THM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-specific component YkoE of thiamin-regulated ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68296">
        <property type="protein sequence ID" value="GAE68296"/>
        <property type="gene ID" value="JCM18909_1424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10546" checksum="3C62EAE5800E9ACA" modified="2014-03-19" version="1">MLVVAYRKAGPKLVLVAGALTGFAEAIYERISYYPMFRFGDTIVYFVFMIVSGALLGGLVAWGIVRGLAAAGALSPFAVSRELRGGKSPRSTISSRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY6</accession>
    <name>W4THY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68038">
        <property type="protein sequence ID" value="GAE68038"/>
        <property type="gene ID" value="JCM18909_1145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="249" mass="26731" checksum="D5C8DFE4922425F3" modified="2014-03-19" version="1">MRLAMDPTIAHKVSRSQIAREIAVTYVAGEDVASAVDKAADQVSKGLDVSLHPLDPDPADLAQARRAMVRLCGVIERLGADPAFNGHAEVSISLAALGLRVSDDLARDHARQVCQVARDNHVAVTVDDEGPDIHDRSHRIVMDLLSEYEDTGIVIQAARHDSLMQVRELAAPGRRIRLCKGSYTGPRSVTLIRPHDVDLRMAACLRALMTGPSTVMLASHDRLCGARRATYGKSGSSAGVPNAARNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ8</accession>
    <name>W4THZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoplasmic axial filament protein CafA and Ribonuclease G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1717</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68570">
        <property type="protein sequence ID" value="GAE68570"/>
        <property type="gene ID" value="JCM18909_1717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="616" mass="68336" checksum="B33FDBCC7B4BCDA7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI38</accession>
    <name>W4TI38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyribonucleotide nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68098">
        <property type="protein sequence ID" value="GAE68098"/>
        <property type="gene ID" value="JCM18909_1212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7807" checksum="33005D1FC18CC4D3" modified="2014-03-19" version="1">MALNPAVYYDVVAINAASMSTQLAGLPFSGPIGGVRMALIDDQWVCFPSVDQRKESTFDMVVAGRVLADGDVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI39</accession>
    <name>W4TI39_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Argininosuccinate lyase</fullName>
            <ecNumber evidence="3">4.3.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1551</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68416">
        <property type="protein sequence ID" value="GAE68416"/>
        <property type="gene ID" value="JCM18909_1551"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="5">
        <location>
            <begin position="9"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="302" mass="33416" checksum="7CEE1582952D387E" modified="2014-03-19" version="1">MEEDVVSGRFVAQPEDEDVHTALERGLMERAGKDLGGRLRAGRSRNDQIIALLRRYLREEARSLAGELLGLVHVLSRRAEDVGDAVIAGRTHMQHAQPVLLAHQLLAHAWPLLRDVQRFRDLDARLDCSPYGSGALAGSSLGLDPEAVARDLGFSSSVPNSIDGTAARDVVAEFAFVAAQVGVDLSRLSEEIIIWNTREFGYVTLDDSFSTGSSIMPQKKRTRTSLNLPAARQGVSLVILPVSWLPLRVCHWPTPVTSKRIKSRYSTRLTSFTCCCQLSLEWWTPPCSTPIAWPRWLVKGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI55</accession>
    <name>W4TI55_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68436">
        <property type="protein sequence ID" value="GAE68436"/>
        <property type="gene ID" value="JCM18909_1574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="65"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13562" checksum="2D90A9219ED3810D" modified="2014-03-19" version="1">MAAAPGRVDVVPVPSSRRAVRKRGADHAADMTRSALEWLKVPDATVNQLLHRTRQVADQLEVGDEQRGVNQRGSMRAGPGSGDVIIVDDVRTSGATVEEACRALTRSGRQVLAIVVLADAATATRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI64</accession>
    <name>W4TI64_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68123">
        <property type="protein sequence ID" value="GAE68123"/>
        <property type="gene ID" value="JCM18909_1240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_38N" evidence="1">
        <location>
            <begin position="165"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="316" mass="35039" checksum="B362F90AD7CB021B" modified="2014-03-19" version="1">MIVDLGGVWDSPGFQSEGLVVRPDGSIIKALNPRNTWIPVETDAEGHIDVYVEAASNPILLAQPPFQPTEDGDKLTASTDAYYSLKRADLVVVNDEVRELIADIVTLSGLAAQLPEDSERRWDVRRALDRAIDRLDLFDVVSSASAARSELAPALTRPAHDSAQTMTAIGHAHIDSAWLWPLRETRRKVARTISNQLNLIDTDPAHIFAFPAAQHSAWLEEDHPDLFARLQKAVKHGRIIPVGGMWVESDANLPGGESMCRQLLYGQRYFMAKFGHHCPEVWLPDSFGYSGALPQLAKLAGARWFFNPKDFLESGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI84</accession>
    <name>W4TI84_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,4-diaminopentanoate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1612</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68471">
        <property type="protein sequence ID" value="GAE68471"/>
        <property type="gene ID" value="JCM18909_1612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="144"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="348" mass="36216" checksum="86A5F7E37EC04076" modified="2014-03-19" version="1">MTATNPIRVVQWGLGAMGQGMAKLITAKDGLELVGAIDVNPALDGKDIGVVLGIDPLGANVTTDPASVLDSNKVDVVTIATTSWVRDQIADLRTIITAGINVVSIAEEMSCPEAQNPDMAKELDELAKKKHGVSAVGVGVNPGFVLDHLVVALSSGSQEVTHIEARRVNDLAPYGQTVLRTQGVGTTPEEFKAGVADGSIVGHVGFPESIRLISDALGLGVDSIEQHIEPIIAKVARPARDRTVEPGQVAGCNHTAVGRRAGEEVIRLIHPQQVAPEAEGQETGDFITITGVPDISMTTGPEIAGGKATAGICVNTIPRIVAATPGLKRIIDLPSPCALMGPSAYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI93</accession>
    <name>W4TI93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reactivating factor for D-ornithine aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68481">
        <property type="protein sequence ID" value="GAE68481"/>
        <property type="gene ID" value="JCM18909_1622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11408" checksum="BE4CCC0F341399E5" modified="2014-03-19" version="1">MSVHGLTRSMTARAAREAALGAGAIVTMTTVGAMDEFDLEDLQESRPNIILLAGGVDDGEKRIVVENAKVIASAQLGVPVVYAGNSRVRRRVEHIFCRCRPAADMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF0</accession>
    <name>W4TIF0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine_BP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68312">
        <property type="protein sequence ID" value="GAE68312"/>
        <property type="gene ID" value="JCM18909_1440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="SSF89957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine_BP" evidence="2">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13288" checksum="A6104D90A35A202B" modified="2014-03-19" version="1">MLPMSNPVVSCRWCKTGTMIVAFNLVPSGGRASREDGGVADAVAAAVRVVRDSGLPNHTSSMFTEIEGSWDEVMDVVKRATEAVAQYGTRVSLVLKADIRPGRTGEMTAKLERLQGELDKQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH3</accession>
    <name>W4TIH3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transport ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68337">
        <property type="protein sequence ID" value="GAE68337"/>
        <property type="gene ID" value="JCM18909_1466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16506" checksum="B58077FC38995C4F" modified="2014-03-19" version="1">MATALLILAQAWLLSRGVSSVFATHHLDGVAMWCGLLAAVFCGRACLAWLQESLAHRASASVKSQLRRDILQARLSRPTDATMPSGTLISLVTTGLDALDGYYSKYLPQLVLAVIVPVVLATAIGLNDLTSVVIVVVTIPLIPVFMASLAGGPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH6</accession>
    <name>W4TIH6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NagD-like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68238">
        <property type="protein sequence ID" value="GAE68238"/>
        <property type="gene ID" value="JCM18909_1361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19051" checksum="F8E5638AD52EDA32" modified="2014-03-19" version="1">MTVDKLGVMRDPADIECWLTDMDGVLVHENHEVPGASDLINRWVDTSKRFLVLTNNSIFTPRDLAARMQASGLTVPEDNIWTSALATAHFLADQQPGARLYVIGEAGLTTALHEAGLSSPTSTLTTSSSERLVPTPLRPLPGPFDSSSTVPGLSALTLMRLAPARRARCLPPVPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN8</accession>
    <name>W4TIN8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68293">
        <property type="protein sequence ID" value="GAE68293"/>
        <property type="gene ID" value="JCM18909_1421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HA2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="254" mass="26914" checksum="1829A7E72DE8D989" modified="2014-03-19" version="1">MALPTPLPQDQVAAAEEELRDLGAVDAEGRITARGRHLATFPLDPRLARALNDGAAIVGSRRCAEIAAMLGLEDGQVDLVGQWRQLRSGRHPEAVMWRREADRLARLINDVPPTDITDDDAVATVVSLARPGWIARSRGEGSTSYLLACGTGVDLPRNCPPGLLGQPWLAVARTSRITSGALIRAAVPLSESDALESGEAMLTNDITVTWDGGKVRGRRVSRSVRSSCRRPRSARSGTGSPRGAGSGEVGGDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP9</accession>
    <name>W4TIP9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68661">
        <property type="protein sequence ID" value="GAE68661"/>
        <property type="gene ID" value="JCM18909_1812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26929" checksum="F4B8B94252F67D82" modified="2014-03-19" version="1">MPEVNTDLPVVAIHGITSSPTTWGGLVLAFNIEGVIVHQLSLLGHGPIGIRRGVGTDYPLEAFATDVIEQMDALKVDKCALVGHSLGALVSSMVAQRQPDRVDRVLLEEMPVPRRVRQDPPPMRAYVDAIFMEVAAFAGRKRFDPKKMVWKVSRELLKPRPQWWDGLSRMIMPVLVIGGGKASYLRQDRLSDVAHALPDARIVTIDGGHRTHITKGDEFCDIAVPFLTNGKYANRRHNGIQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ1</accession>
    <name>W4TIQ1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NifU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68840">
        <property type="protein sequence ID" value="GAE68840"/>
        <property type="gene ID" value="JCM18909_2005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16694" checksum="842BF6C1FA563074" modified="2014-03-19" version="1">MVSGITLPFAGLLVSAPGLDEFLNQVRVEATVGAVMATVLEGTWERIGAGFRTALTTALERTDEWVGGPDSKPLNDVETLRRCADELIGGPVGAVAAMHGGSIELVDVSVGDEERRVDVTMKGACRGCPAAIMTLHQRLERQLSLRLREPVTVREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR6</accession>
    <name>W4TIR6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68855">
        <property type="protein sequence ID" value="GAE68855"/>
        <property type="gene ID" value="JCM18909_2020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6792" checksum="8D211DE5C64BF60D" modified="2014-03-19" version="1">MAIGKGYGSAADRTYRVAYNDRTIHPFQPLTPSAIVDDSVLRRHHRRPTPDEYLQPNVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX1</accession>
    <name>W4TIX1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyribonucleotide nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68099">
        <property type="protein sequence ID" value="GAE68099"/>
        <property type="gene ID" value="JCM18909_1213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="244" mass="26328" checksum="C413F813D005C766" modified="2014-03-19" version="1">MMVEAESTPATWGLVRGGRTAPTEEVVATGLEAAKPFIKVLCDAQVALAAKLPKETYDFPVFKDYEDDVYAAVEEKAADELSRIEQIAAKLERQEAESELKARIKAELAETFPEREAEISGAFKAVMKKRSSASASLTRVCESTVVDRVISAPCRLRSASFRGSTVRPCFSAARPRFWACRLSTCSIWSKSLTPSPRKTPGGICTTTTCRRTPPVKPAVLVPRSVARLVTVTSPSGPSSGVADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ26</accession>
    <name>W4TJ26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68164">
        <property type="protein sequence ID" value="GAE68164"/>
        <property type="gene ID" value="JCM18909_1283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6263" checksum="F98FDB4102E8419F" modified="2014-03-19" version="1">MAGTSDGGFDARAMGMEKKYRGVVRVRLLPQGDSPALGERNLCEHEHQVTCGTGEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ48</accession>
    <name>W4TJ48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68567">
        <property type="protein sequence ID" value="GAE68567"/>
        <property type="gene ID" value="JCM18909_1714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="23647" checksum="B55EB05B993289C6" modified="2014-03-19" version="1">MTGSDGISTYSQDLVVINAMMRGDQRIVGNRELSEDERWLYRIGPGSDAPRPTGSLPPIRPSRSVTSQAHDPQDRGVVAAPQPQARHRWPRPYEVAAGACASAAATGVVGGLGIGGTMIGAAVTSLVIALGGALFTRWFSRTHRSVSGAHQRRGMWARMVAVALVVSVLTVLVGVVWLAPSAGQEAGWWVHRATGSLEQWRESAQRAWPYLRKAWNAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ53</accession>
    <name>W4TJ53_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2344 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68572">
        <property type="protein sequence ID" value="GAE68572"/>
        <property type="gene ID" value="JCM18909_1719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="2">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="246" mass="26698" checksum="7CA1425595749321" modified="2014-03-19" version="1">MTMSKRAQQQPEQQAPPQQRLRMRYAKRGTARFTSHRDFARAFERALNRAHIPMAYSSGFSPHPRISYANAAATGAASEAEYLEVALAEVCDPQKVLMVLGREMPPGMEVLEVVETDRTPFTELLTASAWLIEPAGDVPGLAEAVEAVMTAETVDVQRMTKSGMRTFDVRAALIGLDVANGCVRLMLRHVTPLVRPDDVLRAVATRCPAVDAARVTRLAQGACNEDASGVSTALADPFTGAAMTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ61</accession>
    <name>W4TJ61_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric-oxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68199">
        <property type="protein sequence ID" value="GAE68199"/>
        <property type="gene ID" value="JCM18909_1321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11685" checksum="33048CFE667E1FB6" modified="2014-03-19" version="1">MGDEGKKPEKTRRRPMVVSKGWVQGIALVMILGFTVMGILAYHTYNDSIPIPDKVVSTTGEVLFTHDDIVAGQEAFNNRASWNMGPSSATVGTLAPTSPPTICVVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC8</accession>
    <name>W4TJC8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA small subunit methyltransferase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69055">
        <property type="protein sequence ID" value="GAE69055"/>
        <property type="gene ID" value="JCM18909_2237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="257" mass="27858" checksum="3033AC5A5643CF90" modified="2014-03-19" version="1">MRDARVIAAEDTRRLRDLLRRLGVESSARVVSYFEGNESARTPELIDCLRDGDDVVVVTDAGMPSVSDPGYRLVIAAIEHGIVVTSVPGPTAVTTALAISGLPTDRFCFEGFLPRKPGERRRRLAELAQEPRTTVLYEAPHRLADLLDDAADVLGTDRRAAVCRELTKTYEEVRRGGLGELAEWAREHARGEITIVIEGAPGTVVGIGEAAEMVAELTADGIKRSKAVAQVARATGVDRHELYDAAQNALTTDKEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD9</accession>
    <name>W4TJD9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68528">
        <property type="protein sequence ID" value="GAE68528"/>
        <property type="gene ID" value="JCM18909_1673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="33408" checksum="FE684E5D5EBE2156" modified="2014-03-19" version="1">MATRSAAPNTVTKVVQGSSSAPDWTATASAISNSVVSITVTTGNGGGEGSGVVVDSNGDIVTNNHVVSDVASGGQLTVSMGNKTYDAKVVGSDPSTDLAVIRVTNPPESMKPIRFANSSKLTVGAPVMAVGNPLGLSGSVTTGIISALNRPVTTMSRDDSDDLLGSYDSSSGVVVTNAIQTSAAINPGNSGGALVNANGELVGINSSIASLPSADRSQSGNIGIGFAIPSNLAKSVADQIIRTGKVTHAFLGISVRDAAAVKAGVKVRGAGIATVIPSSAADKAGLRRGDVITRIDDTDIASGESLVGLIRSFKAGQKAKKSVISVVPRRGRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG5</accession>
    <name>W4TJG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding protein Obg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68563">
        <property type="protein sequence ID" value="GAE68563"/>
        <property type="gene ID" value="JCM18909_1710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="1">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="47" mass="4715" checksum="16BAD99A4169B077" modified="2014-03-19" version="1">MAIPSFVDRATLTAVAGKGGHGCASVKREKFKPLGAPMVATVAMAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ3</accession>
    <name>W4TJJ3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Pyruvate kinase</fullName>
            <ecNumber evidence="5 14">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JCM18909_1864</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="5 14"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68712">
        <property type="protein sequence ID" value="GAE68712"/>
        <property type="gene ID" value="JCM18909_1864"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="15">
        <location>
            <begin position="3"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="16">
        <location>
            <begin position="348"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GAE68712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="464" mass="50411" checksum="6BA7D2C62C01D065" modified="2014-03-19" version="1">MTSHDAMKELMEAGMNIARLNMSHGDYSEHQERLDLVRSVSKELGLNVAALADLQGPKVRTGLFEKAEGESNGKIDLKIGDKFTITTDDIVGNQERVSTTFKGLPQDCKPGDVILIDDGKTVLQVDSVSGNDVNCHCTVAGPVGDHKGINLPGVAVSIPALTEKDEENLRWALKAGIDLVALSFVRHGSDIDRVHEIMGEEGRTVPVIAKLEKPQAIENLDEIIDVFDAVMVARGDMAVECPLEEVPLIQKQIIEKARLQAKPVIVATQMLESMIHAPRPTRAEAADVANAILDGADGVMTSAETSVGDFPGETVRTMAKIVESTEARGLDKIAKIDWDPHTTSGIMSKAAAEIAKRAEAKFIVAFTKSGDTARRIARLRPSTPLIVFTSDETTTKTLAWVWGAHAVVTPVFKNAEELYRWVNAYLRDKGFVPVGDRVVVLSGSPMDIPGKTNNLRILRIKEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ0</accession>
    <name>W4TJQ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68762">
        <property type="protein sequence ID" value="GAE68762"/>
        <property type="gene ID" value="JCM18909_1919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="165" mass="17562" checksum="FEB51DFF49DBC518" modified="2014-03-19" version="1">MALSIRHVGPTAARALATHFGSVEAIREASVEELAGVDGVGEIIAESVKRWFEVDWHQEIISRWAAAGVRMAGDRDEAPEQTLEGLTVVVTGSLEGFSRDEAKEAIVSRGGKAAGSVSRKTDYVVVGENAGSKETKARDLGRPILDEAGFRYLLENGPQGITTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU2</accession>
    <name>W4TJU2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1849</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68698">
        <property type="protein sequence ID" value="GAE68698"/>
        <property type="gene ID" value="JCM18909_1849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8031" checksum="B94C874AA9DA00F3" modified="2014-03-19" version="1">MDRSSGLINMSVSLNLLPVVGVPLPFISIGGSALVSALLAVGLLLACARTEPDARRSTAASQRTEPARVTSVVDGGNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV3</accession>
    <name>W4TJV3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68812">
        <property type="protein sequence ID" value="GAE68812"/>
        <property type="gene ID" value="JCM18909_1975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="358" mass="38301" checksum="167C873D57DF43C5" modified="2014-03-19" version="1">MQHILILAGGSGTRLWPLSHQGEPKQLLELIDGVSLLRMAYERVAGLVSDANILVCTGSSYADTVAKLLPEVPAENILGEPVGRESLNAVAWPAGIIADRDPDGVMAVVTADHIIRPVDDFRAALQHGFDLVNTDPTALVTFGVVPTEPNTGFGYLHRGGRLRPGSRAHQVLEFVEKPSAEVARQYLDSGEYWWNSGMFVWRAATLLDCLSQLKPQTRHHVDELVADPSRLAEVYPCMEKVSVDIAVMEPASHGGCGVHVAAIPLEIQWYDVGSYEALAPHLPSDGMGNNVSGLTVSVDSAGNLLINDRPDAVLAVAGLHDMAVVSTDRATLVVPMSQSQQVKAVVAEVAARAGGRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY8</accession>
    <name>W4TJY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68748">
        <property type="protein sequence ID" value="GAE68748"/>
        <property type="gene ID" value="JCM18909_1904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7374" checksum="9D1AFCDE48CD0A7E" modified="2014-03-19" version="1">MTGAVVVDIPLRWSDMDAQGHVNNVRISELVQESRNQAFYTNGAQEMLDTGIVVVSQDVEFFGPPHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK02</accession>
    <name>W4TK02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68444">
        <property type="protein sequence ID" value="GAE68444"/>
        <property type="gene ID" value="JCM18909_1582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13927" checksum="5B1183EFC021C5EE" modified="2014-03-19" version="1">MRAKASRILALSGYRANSHSGKAVVRTIAEFPRNDFFEASAEELVPLIMAIVDLREKQRLRAWCVGVHGVVFFHLLVFVPADRFDASTVASLRELWLNALARWKLTRHHDGGVLAGTDHSDSQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK10</accession>
    <name>W4TK10_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_1593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68454">
        <property type="protein sequence ID" value="GAE68454"/>
        <property type="gene ID" value="JCM18909_1593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="80"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="403" mass="43522" checksum="C3FD105672997346" modified="2014-03-19" version="1">MIDGVSNAYLRWSTPDVALNDVTRTTPGLDGPTHEEAKTLTETTVSVPISFADLGVREDICQALEGVGIVSPFPIQAMSIPIAVEGTDLIGQARTGTGKTLAFGITILQRITLPGDEGWDEPTTKGKPQALVMCPTRELALQVSKDISTAASVRGARVLTVYGGVGYESQIDALKAGVDVVVGTPGRLLDLSQRKDLDLSHVRIVVLDEADEMLDLGFLPDVENLIGRTPASRQTMLFSATMPAPIMALARSQLHRPVHVRAEGADTQATVPDTQQFVYQAHPLDKIEIIGRILQANDVEKAIIFCRTKRACQRLSDDLDDRGFKTRAIHGDLTQVAREKKRSRNSVMARQPSWWRPMSLPVALTSPGCPTSSTMNVPKTRKHTSTALVAPAARVPKASPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK51</accession>
    <name>W4TK51_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69330">
        <property type="protein sequence ID" value="GAE69330"/>
        <property type="gene ID" value="JCM18909_2534"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:glycolipid mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="PTHR12468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="21988" checksum="D5CDB4591943C3C6" modified="2014-03-19" version="1">MTRTGRATARRFAPTADGRLVAQTWLGSRAILLVVAVVVMTGYHRTFSQVTGNWDVQHYMSIARNGYADPLEMAFFPGLPALLKGGSFLGIPMEVTGVLLGLIGSALAAWALFRIGGMLPACLWLIAPATVFTMVGYTEAPFCAAAFWAWERARAGRWWAAALLAGLACTFRVSGLFLIGALAVLAVLGDGDEAVRRVRLPDVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK98</accession>
    <name>W4TK98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helicase PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69226">
        <property type="protein sequence ID" value="GAE69226"/>
        <property type="gene ID" value="JCM18909_2420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="4">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10698" checksum="212294CCD6F0D54D" modified="2014-03-19" version="1">MCPMTAPLLETTSWIAHVAVSSGLAHLDRPFDYVIPDDLVDRVQVGVRVRVKLAGRLCDGVVVAIDHEQQPGVTLAPVEKTGVRPGSCYTRSAQLCPSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE1</accession>
    <name>W4TKE1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68987">
        <property type="protein sequence ID" value="GAE68987"/>
        <property type="gene ID" value="JCM18909_2166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004716">
        <property type="entry name" value="PTS_IIA_glucitol/sorbitol-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036665">
        <property type="entry name" value="PTS_IIA_glucitol/sorbitol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40398">
        <property type="entry name" value="PTHR40398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03829">
        <property type="entry name" value="PTSIIA_gutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141530">
        <property type="entry name" value="SSF141530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51097">
        <property type="entry name" value="PTS_EIIA_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="Phosphohistidine; by HPr" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="12856" checksum="D708F82D97A7DA7D" modified="2014-03-19" version="1">MLRIGKGVQDMLDTGVIVLFGEPVPDALSDICVIHNRGGRSPLAPQRELLPGDVLTFAGTRYTIDEVGETATSNLGDLGHVVLYFNSPNQSLLAGAIKMSGPPPQLPDQGAILTFEPSSDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR7</accession>
    <name>W4TKR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LacI-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69540">
        <property type="protein sequence ID" value="GAE69540"/>
        <property type="gene ID" value="JCM18909_2767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="307" mass="32785" checksum="DCB05F4D5BF5034C" modified="2014-03-19" version="1">MTERQRRGPSRPSMGDVAAAAGVSQQTVSRVVNNSDAVRKKTVDKVLKAMTEVGYSPNVAARSLRSGRTSAIGVLATDLSRTGELRTVQAIVDATRRSELAVVLDRLEPADDSVRSYRHAMKRMAGRVDGFIIEGLELNHPEDLEAPPGTPVVMAGPPCSRFSTVGCDQASGVRTAVNYLLALGHRTVHLVSGPDYSRQAVVRRQAWQECLETNDCEIPDVISGDWTASSGRDAACYLKDAGATAVLASNDEMAAGAIIGLLDMGVRIPDDMSVVGFDDVLGNTVWPTMTTVRQDFAASVNALLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL07</accession>
    <name>W4TL07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal RNA small subunit methyltransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69222">
        <property type="protein sequence ID" value="GAE69222"/>
        <property type="gene ID" value="JCM18909_2416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NusB" evidence="2">
        <location>
            <begin position="15"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="276" mass="29701" checksum="2813683A0DE7B4A9" modified="2014-03-19" version="1">MTQRLHQKRRKADPARRLAYSALLAVETHGAYANLALADHLRAAKLTGRDAAFATELVDGTSRGTGTWDRIIEAASCRAPAKLQPGVRVVLRMAAHQILAMRVPTRAAVASSVDLAGQVIGERVTGLVNAISRRISTHSLEEWATEIGGRDAVDVMALRTLHPTWIVKAFQDRLGADEVEDALLADNEPPVPTLVVRLGLAERDELGSGTRLDILRGELCVPETPLMSLRCVKAELAYKTRVPNSSSWPCCARPKRTAALASGSTCVPALAANPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL73</accession>
    <name>W4TL73_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YjgF_endoribonc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68904">
        <property type="protein sequence ID" value="GAE68904"/>
        <property type="gene ID" value="JCM18909_2076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02199">
        <property type="entry name" value="YjgF_YER057c_UK114_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013813">
        <property type="entry name" value="Endoribo_LPSP/chorism_mut-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14588">
        <property type="entry name" value="YjgF_endoribonc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjgF_endoribonc" evidence="1">
        <location>
            <begin position="88"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="207" mass="21556" checksum="99B492FEC6C10854" modified="2014-03-19" version="1">MTRWEYFTAPILVHASQQILNNFGADGWELVQIVAGPNPDSLVATSNVRCLTRRNPDERHNEVCRIGDYSSSSCGSGRRLRAGHSDRSQILTSGQLPFVDGELTAVGKVGDAVSAEQAAEAARAAALNAIAAAADVAGGLDAIKRIVRVVVFVNSAPDFTGQAGVANGASQLLGQVFGEHGRHARSAVGVATLPLGSAVEVELTVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC2</accession>
    <name>W4TLC2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69541">
        <property type="protein sequence ID" value="GAE69541"/>
        <property type="gene ID" value="JCM18909_2768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9141" checksum="83AED4B3927BC306" modified="2014-03-19" version="1">MNASHDSLRDDYEVTCPELDTAVDAARAAGALGARMTGGGFGGCAIALVDRDVRSKVATQVADSFQEAGFAHPEFYVVTPGPAALRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF4</accession>
    <name>W4TLF4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-keto-2-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69576">
        <property type="protein sequence ID" value="GAE69576"/>
        <property type="gene ID" value="JCM18909_2809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6935" checksum="0AA90E94C0C03BC2" modified="2014-03-19" version="1">MVSSRRRDLDVLTMGRIGVDIYPLQYGVGLEDVTSFGKFLGGSPTNVAVAAARLRHSAAVVTAVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT9</accession>
    <name>W4TLT9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69477">
        <property type="protein sequence ID" value="GAE69477"/>
        <property type="gene ID" value="JCM18909_2696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="246" mass="26063" checksum="1CFC0434F795E65A" modified="2014-03-19" version="1">MSDPCFLGEVAAAVPGSVVEITGAEGHHAGSVRRIRVGESVLVTDGQGHAVRGPAIEVTKGSVSIETVEILHTPATTHRWVAVQALPKSDRAELAVATLTEMGVREILAWQADRSIVRWKGDKQAKGVARWQAAAREATKQSRRFLVPQVELAQTREVVKRICNAQAAYVLHESASEPLVHQELPASGEVIFIVGPEGGITTQEVEAFVAAGARPVTVSDGVLRTSTAGVVGLAQLWAMANLTACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ7</accession>
    <name>W4TLZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTP-glucose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69771">
        <property type="protein sequence ID" value="GAE69771"/>
        <property type="gene ID" value="JCM18909_3023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="entry name" value="PTHR43511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13232" checksum="AA6CA3A0C6B81D54" modified="2014-03-19" version="1">MSEEGLAAARQKMTEAGVDPVAIEVFTSYYHQLETGDTGLIREDTIFPLTDPPMLDDVEVSEEQAAEALDKTVIIKLNGGLGTSMGLDRAKSLLEVRDGKSFLDIIATQVLSARKAFALDCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM22</accession>
    <name>W4TM22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UbiC transcription regulator-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69577">
        <property type="protein sequence ID" value="GAE69577"/>
        <property type="gene ID" value="JCM18909_2810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13799" checksum="7414D31BCFC4C684" modified="2014-03-19" version="1">MENEPYIADITIDRSRPEPLHTQIAEPLAQLIESGELPPGTRIEDEMSMAARLHVSRPTARRAFETLTQRGLVIRRRGIGTQVTPTRVHRSMNLTSLYDDLQASAKGRAPACSTGQWKPPRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ5</accession>
    <name>W4TMJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M13.009"/>
    <dbReference type="EnsemblBacteria" id="GAE69643">
        <property type="protein sequence ID" value="GAE69643"/>
        <property type="gene ID" value="JCM18909_2886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M13" evidence="2">
        <location>
            <begin position="75"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19544" checksum="9D3D9D0D8DC3BF78" modified="2014-03-19" version="1">MSESTRAETLDKLSAFRPKIGYPERWRDFSAFQLPHGNLVDAAMACSSFQLDHTIEKLSGPMDPDEWLMFPQTVNAYYHPLRNEIVFPAAILQPPFFDVEADDAVNYGGIGAVIGHEIGHGFDDQGSTCDGAGRLRDWWTAEDRSAFEERTKVSSTSMTPLCRCSYSQTALTSTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN6</accession>
    <name>W4TMN6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyphosphate glucokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70250">
        <property type="protein sequence ID" value="GAE70250"/>
        <property type="gene ID" value="JCM18909_3553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="bPH_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="360" mass="38578" checksum="C29BBAEB0A637F6C" modified="2014-03-19" version="1">MFTWTVSVVPHARSQSVRLPQGPIQRKLGLADIDVHTSSGPVTVSCPHLDAMDAQAFAVGQMDPPVPPVAGNCHPSLPRTNHLPLRLSTMNKVLGIDVGGSGIKGAPVDLEVGDFAEPRLRIPTPEKSSPENIVTVLREIVDNFAPTIGDGPVGISFPAPARHGVIPFIANLDQGWAGLHAEKYISDALGRPVTVLNDADAAGVGEVHYGAARGVPGVVVLTTLGTGIGSAVINNGILLPNTELGHLEIDGHDAEKRAASSVKDRKHMSYKDWATKRLQRYYEVVEMLFSPDLFVVGGGISKDHKKFFKYLKLETPMVPAQLLNRAGIIGAAWQAQWRLEHPDATEEEVVKAAKKAKDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN00</accession>
    <name>W4TN00_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-keto-2-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69574">
        <property type="protein sequence ID" value="GAE69574"/>
        <property type="gene ID" value="JCM18909_2807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8424" checksum="D49622C9C2D00745" modified="2014-03-19" version="1">MEVAPTPIDVTNGLGAGDSFGGSLCHGLLEGWSLAETIQAASAAGALVATRLECSTAMPSEPELFAMMAKHPDIAIKEEHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN22</accession>
    <name>W4TN22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69912">
        <property type="protein sequence ID" value="GAE69912"/>
        <property type="gene ID" value="JCM18909_3179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6099" checksum="62F8E16B0287B4D4" modified="2014-03-19" version="1">MKVTFAVASATWLAELMVGLGPDVLSVDPPHAAAPALQLARAAAAANGIEISNREAVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN27</accession>
    <name>W4TN27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69818">
        <property type="protein sequence ID" value="GAE69818"/>
        <property type="gene ID" value="JCM18909_3073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21090" checksum="EE8387D5962FF053" modified="2014-03-19" version="1">MDSDSGHDEDVMTVTVGPHDDLWALAETWYGDGTSWRRIVAANPDVDVDHLVVGQRLALPGATVTVPAGHTGAGRPIDTEQLNQIAPPSEMSKVRTITVEQGDTLSGIAQTQLGDASSWPAIWHLNEGIIADPDHIEPGWELVLPDSPTVDKRASDQHTDEQSGKRENRPLPRLRPPRALRPCYLKGVATPRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN48</accession>
    <name>W4TN48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69838">
        <property type="protein sequence ID" value="GAE69838"/>
        <property type="gene ID" value="JCM18909_3094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6117" checksum="7CDC19F894AEBE0C" modified="2014-03-19" version="1">MLTINAERRRARISTTLGPVMIGMDPHTRSITIDVMDGQETAIAGGRVTTVAPRPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN62</accession>
    <name>W4TN62_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoglutarate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69649">
        <property type="protein sequence ID" value="GAE69649"/>
        <property type="gene ID" value="JCM18909_2893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21388" checksum="D610551CEA214992" modified="2014-03-19" version="1">MPSTDTAHHTTDEREVQSLDRVVIRFAGDSGDGMQLTGDRFTAESAIHGNDISTLPNFPAEIRAPQGTIPGVSSFQVHFANYDIATPGDQPDVLVVMNPAALAANLGDIRRGGLIILDSAEFTAKKISKKAGYTEDPRNDGTLESYQVVELDLTGLAVAAVEPFNLGRKNSERAKKHVRPRTADLAIRTSPRPLGEVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN77</accession>
    <name>W4TN77_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrB</name>
        <name evidence="14" type="ORF">JCM18909_3253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69977">
        <property type="protein sequence ID" value="GAE69977"/>
        <property type="gene ID" value="JCM18909_3253"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="13">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE69977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="296" mass="31220" checksum="33845DF5F45E27FE" modified="2014-03-19" version="1">MDNSVRVRVPATSANLGPGYDCIGLALDLWDEVSVEVLDRPGVMIDVTGEGADTVPHDESHLVMATLRQGLVELGYPRPDAGLHLTAINSIPQSRGLGSSAAAVVSGLALAWGLARPGFPLDRSALLTMAAAIEGHPDNAAPAIFGGAQLAWLDGEAVNHIGLTVNPSIMFRVYVPDRLVPTVLARQVLPEQVDRVDAVHQVLAASLLVTALTTSPEHLLAATQDWIHQPYRRALMPESAALTDRLRGRGVATVISGAGPTVLALGSRDQLEKVSDVDTAGFVVHDLVLGEGVHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU3</accession>
    <name>W4TNU3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70635">
        <property type="protein sequence ID" value="GAE70635"/>
        <property type="gene ID" value="JCM18909_3994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7809" checksum="5FFEBEE7EB3DECDB" modified="2014-03-19" version="1">MVADDLGEEHVDCSGHVYTHPVKGFFVARSLSWLLVRTWTRVFSSIISPFVSCLYSYCLILGWLGQEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP66</accession>
    <name>W4TP66_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cobalt-precorrin-2 C20-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70322">
        <property type="protein sequence ID" value="GAE70322"/>
        <property type="gene ID" value="JCM18909_3636"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="26806" checksum="DDC23C73F48230E4" modified="2014-03-19" version="1">MNDATSRTLFGVGVGPGDPELVTVKTVRILREADVILVPYTEATTDGPGRAESIITAVVPEITGRIRRIPFSMRERSGVGEKRKASWQVSADAVVTAFDEGARTVALATVGDPTVFSTFTYLRANVEERLPDVTVELSPGITAMQALSAASGRPLVEGKEILALVPATVGINKLGQVLDLVDSVAIYKGGRKLPDVVEQLRSRDRQAVIGTDVTLESEQIITLDEVADAQTLPYFSTVLTTPERTTTGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP72</accession>
    <name>W4TP72_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69994">
        <property type="protein sequence ID" value="GAE69994"/>
        <property type="gene ID" value="JCM18909_3271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9929" checksum="2E947D81C6B335BD" modified="2014-03-19" version="1">MTQSAGNEESCYWVIDHLQEFLHGEMSEHDADAFRRHIAACESCMDEADMEAAVSRALKRCNRTVAAPMQLRSRLVQMHVTYRWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP83</accession>
    <name>W4TP83_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argR</name>
        <name evidence="12" type="ORF">JCM18909_3516</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ArgR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70218">
        <property type="protein sequence ID" value="GAE70218"/>
        <property type="gene ID" value="JCM18909_3516"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="10">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="11">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE70218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="14571" checksum="25938207F938D46B" modified="2014-03-19" version="1">MASQGTLSRDLVEIGAVRGRDHAGNPCYSIPEGEHPSDVTTGSPAWVKLARMTKELCTGVRNNEYLVVLKTPPGAAQYYGSAVDKAGLDIVLGTIAGDDTIALICAIGVDAGELADAFSHMAVTGVPAEILSRSVREECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPA8</accession>
    <name>W4TPA8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">M20_dimer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70243">
        <property type="protein sequence ID" value="GAE70243"/>
        <property type="gene ID" value="JCM18909_3541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="324" mass="34731" checksum="D0B48546F25D34BA" modified="2014-03-19" version="1">MRNRDNAVTRVLDALSRIDSYQWPDLHHPVQEEFLNQVAAMWGLTIDRDDLESSLSPIGPLSRMVAACCAHNVTPTVLSAGYKVNVVPTRASAEVDARFIPGAEEDMILTIKSLAGPGIDFETISRKQATAAPFEGAAVDAIRRAVDAEDPGAVVLPYLNSAGTDAKGFAVLPDGRRINCYGCTPLRLRPTSTSSVSSTESTSESPSDPSFSVPRSSITYCRRLMMSVPHKKPEGGPTATLILDGQEYTLPVIAGTTGDRVIDISNLRQLTGGVTTFDPAFANTASCRSAISWIDGEEGVLTYRGLPIETLAKERVSFVETPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPP5</accession>
    <name>W4TPP5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MMPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70492">
        <property type="protein sequence ID" value="GAE70492"/>
        <property type="gene ID" value="JCM18909_3819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MMPL" evidence="6">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="244" mass="26864" checksum="BE352485AA334654" modified="2014-03-19" version="1">MNAIKEIALALAVGILTDAFLVRMTLVPAVMALLGDKAWWLPGWLDRRLPRLDIEGEGITHEEKLAAWPTADHTEALHAEGIGVEGLFEGLDLHVEPRQVQAVVGSQSSVSAVLLAIGGRLPLNHGRMRSGGLLLPERASRVRRVTWFLDASAPDVVDELCSAMAVLTHLPRRPSRRPRLFLIDHADRIVDPITRDLLESLVREAGEAAVILGAQRRGRIDWLFPQIIHNLAEHHFESSSGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPQ1</accession>
    <name>W4TPQ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper-containing nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70204">
        <property type="protein sequence ID" value="GAE70204"/>
        <property type="gene ID" value="JCM18909_3502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028096">
        <property type="entry name" value="EfeO_Cupredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13473">
        <property type="entry name" value="Cupredoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Cupredoxin_1" evidence="4">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="378"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="624" mass="67259" checksum="8228D405F51E3E2B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ32</accession>
    <name>W4TQ32_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cys-tRNA(Pro) deacylase YbaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70339">
        <property type="protein sequence ID" value="GAE70339"/>
        <property type="gene ID" value="JCM18909_3653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="38"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9540" checksum="03239AE291FFFDCC" modified="2014-03-19" version="1">MPASDSASAATKTLAKAKIPHVLHSYDHDPSNHHFGDEGAAKLGFDPSIMLKTLVVKLAPSGKLAVAVVPVSCQLDLKAFASAVGAKKSRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ34</accession>
    <name>W4TQ34_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysozyme M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_4014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70647">
        <property type="protein sequence ID" value="GAE70647"/>
        <property type="gene ID" value="JCM18909_4014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="15227" checksum="3479B6317CFEC603" modified="2014-03-19" version="1">MTNRVQSLTVDTEPEGMDVSSHDGNVDWPTKASSGMSFAWIKATEGTSYQNPFYASQYNGSQSAGLIRGAYHFALPSNSSGQAQATYFSDHGGGWSGDGYTLPGVVDLEYNPYGENACYGLSQTAMAHGSVISCPPIKNGGAGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ42</accession>
    <name>W4TQ42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70657">
        <property type="protein sequence ID" value="GAE70657"/>
        <property type="gene ID" value="JCM18909_4025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12017" checksum="27C2E9A4FFA50766" modified="2014-03-19" version="1">MNIDRPKIVLLYQSLLGIYGDHGNAVVLTKRLQWRGIDAELLIVEPGQPVPTDGAVYLLGGGEDTARSPPYKSSKLMAGYSPPSTTAQCFFCSVRRLPDLRKVLHHWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ48</accession>
    <name>W4TQ48_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AA_permease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70354">
        <property type="protein sequence ID" value="GAE70354"/>
        <property type="gene ID" value="JCM18909_3669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="10784" checksum="8FF1F83B0C3E579F" modified="2014-03-19" version="1">MAAAGPATLVAYIVAGLLVIAIMYMLGEMVAAHPDSGAFSVYTSRAMGSAAGFAMGWVWWIELVVVVAAEAIAAASTCCHVANSPRLAAHPHLPGRPHRNQPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQA8</accession>
    <name>W4TQA8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70583">
        <property type="protein sequence ID" value="GAE70583"/>
        <property type="gene ID" value="JCM18909_3933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7852" checksum="C11B789E6E70672A" modified="2014-03-19" version="1">MLMCERLLRLRPAIVSPNDAQPARRDTATAAALGADPEVPRERDNRLIGGMHRFNDRVLLIGESRSVTNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQD8</accession>
    <name>W4TQD8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70439">
        <property type="protein sequence ID" value="GAE70439"/>
        <property type="gene ID" value="JCM18909_3757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848885" evidence="1">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="6770" checksum="70B8D88CE80A79D2" modified="2014-03-19" version="1">MRDQLKAAGLAVAVALSATGIAGCQSTDDNVLTIGATAAPPTLDLVSNAAAAIPQVLLYNVYETLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQF0</accession>
    <name>W4TQF0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70633">
        <property type="protein sequence ID" value="GAE70633"/>
        <property type="gene ID" value="JCM18909_3991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14400" checksum="D4798E5BDA796425" modified="2014-03-19" version="1">MSDGRAFAPDLPEAVAELPLPDFDILGQEASLEGLSNEQRDRFRTKAVPEPAGVARARVELSNDARHDVPTTLICCSIPSSQVLELAATGHPMFSAVAQLTNVTVMDLPTGHWPMWSRPQELAGAIREAATSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQF6</accession>
    <name>W4TQF6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Corrinoid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70459">
        <property type="protein sequence ID" value="GAE70459"/>
        <property type="gene ID" value="JCM18909_3786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9184" checksum="4237FB99DED6C4A6" modified="2014-03-19" version="1">MFAVAAAIIGVTVAVCGVVGFIGLVMPHITRLCVGADHRRTLPIGLLLGAIFTVLADLGARMVIRPQELPVGIVTALVGAPFFLFSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQR8</accession>
    <name>W4TQR8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70579">
        <property type="protein sequence ID" value="GAE70579"/>
        <property type="gene ID" value="JCM18909_3929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041100">
        <property type="entry name" value="TQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18202">
        <property type="entry name" value="TQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TQ" evidence="2">
        <location>
            <begin position="314"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="TQ" evidence="2">
        <location>
            <begin position="437"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="TQ" evidence="2">
        <location>
            <begin position="555"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="747" mass="76154" checksum="06AF132700B0BEA8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDF3</accession>
    <name>W4TDF3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66975">
        <property type="protein sequence ID" value="GAE66975"/>
        <property type="gene ID" value="JCM18909_3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="93"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE66975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="166" mass="17624" checksum="A1D5CC9D1C241330" modified="2014-03-19" version="1">MPEMDGLTATRMIVSRHPSVRVVALTTFARRDIVVEAILAGAAGYLLKESEPEAVIAGVRAVMAGQVTVSPEIARGVVEAFSARPSAGGSHQIDLTPVKLSDADDDVLKLLAEGLPNAAIADELCLSESAVKQRLGHLAKKLGVRSRLEVLVRACELGLVIPRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEK8</accession>
    <name>W4TEK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginine pathway regulatory protein ArgR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67400">
        <property type="protein sequence ID" value="GAE67400"/>
        <property type="gene ID" value="JCM18909_458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_repressor_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="5771" checksum="EA7CC99561E94472" modified="2014-03-19" version="1">MGSAIDTSGVHTVLGTIAGDDTVLVVCKVGVDGEDLARLFREMAETGLPAKGLVAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEM2</accession>
    <name>W4TEM2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vitamin-B12 independent methionine synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67241">
        <property type="protein sequence ID" value="GAE67241"/>
        <property type="gene ID" value="JCM18909_286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="328" mass="34863" checksum="C3009C50B2E762BA" modified="2014-03-19" version="1">MIATGIGSLPGTDMRGNLAAMAETFDQLIPLPELPARGVGAHMIGRATAVLVDLPVDHGPGGWRLADSTDHAARSARSWLRSDLDDLEEVLADEEASVKLSFAGPLTLATGLHLRTGGSILADGSALADVTTSLAEGVSQLIAELRRRMPRVTWTLQIDEPSAPAVLSGAVPTQSGLYRYPAMAGSAAVQLWQTVVSGCGKAEVGMHCCGTPIPWALARKAGFSTMWCEVTSLLNMDRVAEWVESGARLGMGIVDTMQVDEVPLVDHLIDRVLWLARRLEIDPAVLKSGILTPACGLAGWSRRDAAEVCRTVKRAGDLVDEQLDQASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEV3</accession>
    <name>W4TEV3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S12p Asp88 methylthiotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_92</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67057">
        <property type="protein sequence ID" value="GAE67057"/>
        <property type="gene ID" value="JCM18909_92"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="19837" checksum="0702C351DAE3DE24" modified="2014-03-19" version="1">MSAADHLMTVHLVSMGCARNDVDSEELAARMEAGGFRLVNDPAEAETVVVNTCGFIEQAKKDSVDTLLAAADLKGNGTTTSVVAVGCMAERYGRELAESLPEADAVLGFDDYGDIAGRLRTVLDGGSLETHVPRDRRTLLPISPVDRPTARAEVSVPGHGTAPDLPAPWLRSPAPEPLGDGSGQGPVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEY0</accession>
    <name>W4TEY0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ORF">JCM18909_117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67082">
        <property type="protein sequence ID" value="GAE67082"/>
        <property type="gene ID" value="JCM18909_117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="263"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="269"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="294"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="316"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="406"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="483" mass="52325" checksum="BD8EC1319AB670C5" modified="2014-03-19" version="1">MSEIEQIDNEREDALKSNNGFSEDQSDYDGDQFDLDARLSLTRVPGMSTDLSDISEVEYRQLRLERVVLCSVWTQGTAADAENAMAELKALAETAGSQVLEAVMQRRTTPDPATYIGSGKVAELAEVVWATGADTVICDGELDAAQLRNLEDRVKVKVVDRTALILDIFAQHARSVEGRTQVELAQLNYLKQRLRGWGGNLSRQTGGRAAGGAGIGGRGPGETRIETDRRRISHRIAVLRRRLTHIESTRASKRADRIRNKVPSVAIVGYTNAGKSSLLNRLTRAGVLVENALFATLDPTTRRATTSDGRVYTLTDTVGFVRHLPHDLVEAFASTLEETAMADVLLHVVDADDPDPLGQVDAVRGVLSGIGASNIPEILVLNKIDRLSDETILTLRSTFPGAYLVSAHTGEGIDKLVEAIEAGLPIPSQRVDVVIPYARGDLMDKIHHNGTIGFIDHTADGTHVVAHLHPALAAEVEEACDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF41</accession>
    <name>W4TF41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane alanine and valine and leucine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67142">
        <property type="protein sequence ID" value="GAE67142"/>
        <property type="gene ID" value="JCM18909_182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="360" mass="37934" checksum="500B4571D5896A52" modified="2014-03-19" version="1">MKVFQAVKRVLIGRKLESSALGETLLPKRIALPVFASDALSSVAYAPDEILITLSLAGTAGFAFSWKIGIAVALVMLIVVMSYRQTVHAYPSGGGDYEVATANLSPRFGLVVASALLVDYVLTVAVSVSSGVQNAEAMIPGLAGHEGVAAAVVIAILTAMNLRGVRESGTFFAVPTYAFMISVICMVVWGLTRIFVLGDNLRAPTADFTAVGTPKYTGLVGVAFVVLMARTFSSGCAALTGVEAISNGVPSFREPKSKNAATTLAMLGGIAVSMLMGILVLASVTGVKMFDETGESHLVDTHGHAVKEQVTVVGQLARTVFYDSFKPGFYIMIVCTMIILFFGCQHRLQRFPGAGLDPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF69</accession>
    <name>W4TF69_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67177">
        <property type="protein sequence ID" value="GAE67177"/>
        <property type="gene ID" value="JCM18909_219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="363" mass="40641" checksum="AB6A10F9346E3BE0" modified="2014-03-19" version="1">MSISITLHRSGTSRTQQVDTTTTGLDLFGSDRAVVAMRVDGNLVDLQRELHDGAEVEPVEATSEDGLNIIRHSATHVMAQAVQQLYPEANLGIGPFITDGFYYDFGNIEPVTPEVLSELEKRMKRIVKENQRFVRRVTTEESAREELADQPYKLELIGTKGKGAEGASVEVGGGELTIYDNVRRNGEVAWKDLCRGPHVPSTKYLANAFALTKFSAAYWKGDQANDQLQRIYGTAWASREDLAAYQQRIKEAERRDHRKLGAELDLFSFPEEIGRASWCSTLRARCCVILLRNTSSLVIWRLGSASFTLRRSLKEGCSTPRVTYPTTPAPCSRRCLSTRSEMRRQRHSSRPGVLPEGYELPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFC0</accession>
    <name>W4TFC0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67456">
        <property type="protein sequence ID" value="GAE67456"/>
        <property type="gene ID" value="JCM18909_517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5425" checksum="0F8925FC9444A9DB" modified="2014-03-19" version="1">MASTSLGPIDRATVATTSWRADSEHYASWGAAAGPSASPAASGTGWVSGTVTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFI4</accession>
    <name>W4TFI4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNARE-like associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67526">
        <property type="protein sequence ID" value="GAE67526"/>
        <property type="gene ID" value="JCM18909_591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="21162" checksum="5A666DED882E9435" modified="2014-03-19" version="1">MNLTAWMASINGVIAANAPHPWVIGALWGLCVVDGFFPPVPSESLVVALAAIGHPSRWLIVPVAAAGAICGDNIAYWVGRQLGHTKLFTGGPKRQKTVAWTTHQLRVRGPLCILVARYIPGGRVVVNAMAGATRFSYRGFLPIDALAGVLWAGYATAIGAGAASFLGNNHILAATVGIIGAIIIGVILDQILRRLMPAPQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFJ5</accession>
    <name>W4TFJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67541">
        <property type="protein sequence ID" value="GAE67541"/>
        <property type="gene ID" value="JCM18909_607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9118" checksum="FD62AEB3E318671E" modified="2014-03-19" version="1">MNDRNPHDPCLHVEAATFMIGSTTLLHDIDFTAHGGELVALVGPNGAGKSTFLSLVAGDQQPLAAGYFLMVGLSRTGRPVSSHSGAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFP5</accession>
    <name>W4TFP5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67795">
        <property type="protein sequence ID" value="GAE67795"/>
        <property type="gene ID" value="JCM18909_880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850724" evidence="2">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12414" checksum="40A428C624C374A4" modified="2014-03-19" version="1">MDPPSSRSLASVLLATAMMSIAAAMVAMPGILAVNTWLGRRWVRWGAIGGVAVGCAAVTLNWVSWIGMPFLIAAGVMVWLPPVRRWMDSLRPVTHEAERPTFPVRYGRVPQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFQ3</accession>
    <name>W4TFQ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67606">
        <property type="protein sequence ID" value="GAE67606"/>
        <property type="gene ID" value="JCM18909_679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17070" checksum="40AEFF265A83CD10" modified="2014-03-19" version="1">MASVCTAEATRAAEERWFDAHPGQDLMDIAAQAVARKAQELLLGGAIDEIMPDWAASQCVLVLVGSGSNGGDGLFAAAALAQRGWRVELAQVMGQPHEAGMAAALDAGCIRVSLGEVTSHSYDLAIDAVLGIGGRPGIPQSLERIDTWLRARQIPVLAVDLPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW8</accession>
    <name>W4TFW8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_60</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67029">
        <property type="protein sequence ID" value="GAE67029"/>
        <property type="gene ID" value="JCM18909_60"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="290" mass="30105" checksum="E17CFEF3C9AA2E6A" modified="2014-03-19" version="1">MSDATFSDHLAWLSAVADIDLVTHGTTSDEATIKDTAVAQPLLVAAALATAWSVDPKIFSQADLLAGHSVGEIAAGAAAGAFSAEAAMVLVRERGRAMAEAASRTATSMTAVIGGDADEVLTAIKAAGLTPANHNGKGQIVAAGTVEQLEAFAAEPPSRTRLFPLSVAGAFHTVHMEPAVNHLREVAAAMPTTIPTVALLSNLDGAVVADGREFADRLVQQMAHPVRWDLCMDTMAQRGITGLLELTPAGTLTGIAKRNLKGVELFNLNTPDQIPAAREFITTHSSKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX2</accession>
    <name>W4TFX2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator of polyketide synthase expression</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_67</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67034">
        <property type="protein sequence ID" value="GAE67034"/>
        <property type="gene ID" value="JCM18909_67"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="195" mass="21754" checksum="694C2B1B8CFC42DC" modified="2014-03-19" version="1">MARTSAMTTATLEEMGRRHSWFRDLSAEERSWISIVARSGIDGFVQWFTDDDAEPYSPIDVFDVAPRSMTRKISLHQTVELVRTTIDVVEAQIETEMPRGDRQVLRTAIVHYSREVAFAAAEVYARAAERRGTWMNVWNPSSLMPSCEPTPMNSSSRELLLSAGARASTSALSSGGPRRPSMNSTCCDVMENACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ5</accession>
    <name>W4TFZ5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_492</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67432">
        <property type="protein sequence ID" value="GAE67432"/>
        <property type="gene ID" value="JCM18909_492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="161"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="260" mass="27880" checksum="37122CDE1C6544F6" modified="2014-03-19" version="1">MIYTTIDGRTLVAASCADLAAFDPYPRSCPRTPATRRDASLTWTFGHDKHTTVRTIKPVSRLPVTYDDDALLARNDPRLAGLTPDILEFTADSTTGDLDRLVDQLHGAAPSYAAYAGAENPDTLQAFIQQQGIVRSGLAAGFLLILVACTAAFVELRWGMRRTIAVQQAVGTPARILRRSFLMQMIVTILPAQTMSLVVGVLAGWAINAAIGSTDANQSFDPTIAALPVTMWAVSVLAIMVTAFATGAPRFQLSAVRDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA8</accession>
    <name>W4TGA8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-galactosidase fused to beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67567">
        <property type="protein sequence ID" value="GAE67567"/>
        <property type="gene ID" value="JCM18909_637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="PTHR23421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_35" evidence="5">
        <location>
            <begin position="100"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="526" mass="57204" checksum="09FEE09DCDA5E4F4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC1</accession>
    <name>W4TGC1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67836">
        <property type="protein sequence ID" value="GAE67836"/>
        <property type="gene ID" value="JCM18909_923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20344" checksum="CA38C82D623A223A" modified="2014-03-19" version="1">MGHILVVSGAGRYVDNIHDFDATSEAVSQVLTERGHQVEVRRSYPEALDHLAGADLLIVNTGGGDPEEEWDYIPEWSRAHSKILEHHEAGKPILGLHTACNTFCDWDLWPSILGGKWVLGVSGHPERSYAVFEPMPEAADHPILRGVEQVVVYDERYSDLDINPLAAPLLFHETGEEFHRCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF3</accession>
    <name>W4TGF3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67234">
        <property type="protein sequence ID" value="GAE67234"/>
        <property type="gene ID" value="JCM18909_279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="15338" checksum="DD803465A6EB7651" modified="2014-03-19" version="1">MTIFRVDNPHTKPLNFWAWLMEQVHRRHPKVIFLAEAFTRPEMMAALGKVGFQQGYSYFTWRTTKWELEAYLDEVSHQTSHFYRPNFFRQYPRHQPCLSQRRQSGRLRYPCDPGRDDEPVVGHVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT6</accession>
    <name>W4TGT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68180">
        <property type="protein sequence ID" value="GAE68180"/>
        <property type="gene ID" value="JCM18909_1300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16822" checksum="BD15A6448ABD6948" modified="2014-03-19" version="1">MASPNKKNRPGGYPVWLWVVIGLIAVGSLASLGSDPGAAVFGLLIVAAFVAVPAIRHYRMTKYFASEEFQAQKAALADVVREHNEIANYVEEIRTRGLFELGASSSGAMSHLATTSNTSNWNYKRDRNVAELGDPHVHNASLQVVNNAKADPLTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW7</accession>
    <name>W4TGW7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68011">
        <property type="protein sequence ID" value="GAE68011"/>
        <property type="gene ID" value="JCM18909_1117"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="267" mass="29270" checksum="E74ADC8430C83F13" modified="2014-03-19" version="1">MNPYLPDASDPRMAGVKPLSEGLRPVSRPRRLRTTPAMRRMVAETRVVPAQLMLPVFVKEGVDSPVEITSLPGQFQHSTESIKELATQAAEAGIGGIDLFGIPEHKDEIGSQAWDPKGILNAGISAVREAVGDDLVICADTCLDEFTEHGHCGALTLMIASIMTPLCRYMPRWRSPKRAPEPTWSPRRMMDGQIAVIRDALDREGFTDVSSWPIQLSTLQPSLAPSGTPSTVPLRVIARLTSRIHRTAGKACAKLFSTSPREPIWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH31</accession>
    <name>W4TH31_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-proline glycine betaine ABC transport system permease protein ProV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68091">
        <property type="protein sequence ID" value="GAE68091"/>
        <property type="gene ID" value="JCM18909_1205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="4"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="193" mass="21349" checksum="9E1CDFE72209145D" modified="2014-03-19" version="1">MDLVRASHLYKVFGKHERQVIERLKAGESREELASLGTAAVIDVSFEVAKGETFVVMGLSGSGKSTLIRMINGLWFPSEGTVEVAGKVVSDMNDAQLRALRRDHVSMVFQHFALLPHLTVRENAAYGLKLQGKLKQKERLEKANEWLNTVGLNGWGDKYPHQLSGGMQQRVGLARALAAETDILLMDEAFFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH44</accession>
    <name>W4TH44_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67444">
        <property type="protein sequence ID" value="GAE67444"/>
        <property type="gene ID" value="JCM18909_505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="8741" checksum="7436A24F7F44F6C4" modified="2014-03-19" version="1">MAVTTASDEDWYASLGASRVRLVGGSPSRAADEADGDPDLALWANEVTSAPQVELLPFLREQSVSATAHRFGNPDAGVLSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH5</accession>
    <name>W4THH5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Substrate binding component of glycine/betaine transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67888">
        <property type="protein sequence ID" value="GAE67888"/>
        <property type="gene ID" value="JCM18909_980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4229" checksum="BD23800536044E0D" modified="2014-03-19" version="1">MVDTTKRGGQQDTAISRWMADNPDWVHDWLAGRLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI9</accession>
    <name>W4THI9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67967">
        <property type="protein sequence ID" value="GAE67967"/>
        <property type="gene ID" value="JCM18909_1069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="1">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11855" checksum="17F638A6CD9412FC" modified="2014-03-19" version="1">MGEWLDDANALVTRLRTALDATVGVRGVAVIPTNMIDRYGLSGPVSRASGVDLDTRRRTAVYDELKWPEVVIEPRGDATHDWQRYVTMRRCRRAYAVRSSTGYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK9</accession>
    <name>W4THK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67997">
        <property type="protein sequence ID" value="GAE67997"/>
        <property type="gene ID" value="JCM18909_1102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-1" evidence="5">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="10871" checksum="83F35E0058DFF68F" modified="2014-03-19" version="1">MTAATPTDRRSQEKSERRNDGIDETAAEIIIALGGAENIEDVDACITRLRVSVKAPDQVNKARLKNLGATEVFEVGGGVQAVYGAKAILYKNAINAQLGIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR1</accession>
    <name>W4THR1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c-type biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68052">
        <property type="protein sequence ID" value="GAE68052"/>
        <property type="gene ID" value="JCM18909_1160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="205" mass="21295" checksum="D94A1BEBB92DC3D2" modified="2014-03-19" version="1">MTGLGAADVIEGQRRARTVVGTVLFVVGFTVVFVATGTIIGTLGKVLVGHRRAIEIIVGALTVVLGAMFAGLVSLGRRELRIHRLPRAGLAAAPILGIVFGLGWTPCIGPALSVVYGLSLTQGSAVRGAVLATCYSLGLGIPFIAAAAAVVWMGRTIDAVRTHQHGVQRFGGILLMAIGVLLVTGWWESIMAMLRAWAAKFGAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV9</accession>
    <name>W4THV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol uptake facilitator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68525">
        <property type="protein sequence ID" value="GAE68525"/>
        <property type="gene ID" value="JCM18909_1669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4011" checksum="5DC27070C9B09F52" modified="2014-03-19" version="1">MLPIKGKGDSDWGYAWVPVVGPMIGAVLAALTYSIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID5</accession>
    <name>W4TID5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68531">
        <property type="protein sequence ID" value="GAE68531"/>
        <property type="gene ID" value="JCM18909_1676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="5037" checksum="E4DA46C0FB772C65" modified="2014-03-19" version="1">MTTQALAPNTILGNISLSDPSEIDTTQPFPEAVGVDVHGNDEPRDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG9</accession>
    <name>W4TIG9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68765">
        <property type="protein sequence ID" value="GAE68765"/>
        <property type="gene ID" value="JCM18909_1922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="72"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17197" checksum="A932C01E636A9271" modified="2014-03-19" version="1">MTFKPSHVHIGTDHAAFELKEYLVGKLTEAGYQVVDHGAASYDSQDDYPDYCIPCAQAVVAEPGSLGIVLGGSGNGEQIAANKVKGIRAALAYTVEIAELARLHNNANVVSLGGRMQTQEEAWQIVETFLTTDFSHEDRHQRRIDKLIRWEDKGSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII4</accession>
    <name>W4TII4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68591">
        <property type="protein sequence ID" value="GAE68591"/>
        <property type="gene ID" value="JCM18909_1738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="17306" checksum="AF9AFBE52671C311" modified="2014-03-19" version="1">MGKGHWGDEELERLLDRECSVAAFLNGLWFTEVSGRREATLVLNEFQKVLGTPVLLMELRDEQESLVRVVEVHRRIDNVAMDKARKEQERRREQLEKAAEKRLEVIVLVLTVISTMLALLALVSDPNLGLFFQSVSYSQGSSRSSVVSASNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN5</accession>
    <name>W4TIN5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67994">
        <property type="protein sequence ID" value="GAE67994"/>
        <property type="gene ID" value="JCM18909_1098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16221" checksum="B7D185A1FC7BB764" modified="2014-03-19" version="1">MWFWIVIAVVVLGICAGLGGGSKGGDGQKSGSDKAASAPATSQAKQVEKPAAKTTDEDQVKGDLALLKGWKLNKDEFTVHVMGYVRNNSDESINNYVQIEFNAYDASGNNTDTCMANTNTIDAHGKWKFDAICSKDPSEIKTVKFKDITGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ31</accession>
    <name>W4TJ31_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68408">
        <property type="protein sequence ID" value="GAE68408"/>
        <property type="gene ID" value="JCM18909_1543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dhC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="147" mass="15184" checksum="08BCE114A26CBA1F" modified="2014-03-19" version="1">MSGGAHPYSVGNAHRHIPEILQSLRMAGAEKPHLSVSAVLVPMTRGILAVCTAPSQASSDDLLARLREVYGDEPLIHVTDAYPDTHDVVGSAMTHINAVGDPDNGLATIVVALDNLVKGTAGAVIQCLNVALGLPETTGLPLIGLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ63</accession>
    <name>W4TJ63_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein export cytoplasm protein SecA ATPase RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_1576</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68438">
        <property type="protein sequence ID" value="GAE68438"/>
        <property type="gene ID" value="JCM18909_1576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="87"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE68438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="369" mass="40495" checksum="5C50F3411DCC1D33" modified="2014-03-19" version="1">MNLMDRVLHAGEGKIIRRLNRIVGQVNSIEEDYVAMDDDELAGQTADFRQRLDNGESLDRLLPEAFATVREASKRVLGKRHFDVQIMGGAALHQCNIAEMKTGEGKTLVGLLPAYLEGLLGEGVHIVTVNDYLARVQSEQMGRVHRFLGSSISAILSDMPPMARKEAYKADVTYGTNNEFGFDYLRDNMASSLSECVQRGHHYAIVDEVDSILVDEARTPLIISGPAEENKQCTRNSPRSSRGSNATSTTRWTRRNAPSLYLGTESPSLRRGSVSRTFMSQRTLRLSGTSTTPSRPRSFSIAIRTTSSSVVKSSSLTSTPVVLLLAVVTTKASTKPLRPRNTSRSRTSIRLSPRSPCRTTSVCTTSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ70</accession>
    <name>W4TJ70_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="3" type="ORF">JCM18909_2001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68836">
        <property type="protein sequence ID" value="GAE68836"/>
        <property type="gene ID" value="JCM18909_2001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10586" checksum="DF26EC1998649AB2" modified="2014-03-19" version="1">MSVATAEPIAHRLVGQESTWTTVVWDDPVNLMDYVTMVFMRYFGYPRERATQLMIQVHNQGRATVAEGSKEEMEVAVHAMHGYGLQASVEKGGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA4</accession>
    <name>W4TJA4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69030">
        <property type="protein sequence ID" value="GAE69030"/>
        <property type="gene ID" value="JCM18909_2211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22551" checksum="B83E1642F2062A6B" modified="2014-03-19" version="1">MTIADLARESKLHVNTIREPLNVLVSLGLVEREKLPATGRGRPYWGYTSRTLSGPNSPADLLRHLSRSTIRWIRDTSDDPVAAARSLGEYLGDDALAMANVPDHTEHSPGDKFSLADHMTKIRVFLTAFGFSAEPHPTNPTALILRACPFVDPNDTDPVAMAIQQGMLYRVIERTGGNSVHVTLHHEEDSAPCELVLTSNFTNAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB4</accession>
    <name>W4TJB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor biosynthesis protein MoaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69040">
        <property type="protein sequence ID" value="GAE69040"/>
        <property type="gene ID" value="JCM18909_2222"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12755" checksum="993F6197FDE3921E" modified="2014-03-19" version="1">MDEIRARIITVSDRCAAGAALDRSGPLAASLLAELGYSWLKVDPVTVVPDGIDSVGSALRDALENGCRLVVTTGGTGISPRDLTPEATEPLLVARLDGLAEQVRASVRVAPLWQDYRVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL0</accession>
    <name>W4TJL0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68334">
        <property type="protein sequence ID" value="GAE68334"/>
        <property type="gene ID" value="JCM18909_1463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9217" checksum="8753495043345399" modified="2014-03-19" version="1">MNKRIDDDAEGLSAGERRRVALARALVRAEQAEAGLLVLDEPTAGLDADTEATVLEAVRASGASVLVVSHRRNIIAAADVVVDLEVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ7</accession>
    <name>W4TJQ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconate transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68663">
        <property type="protein sequence ID" value="GAE68663"/>
        <property type="gene ID" value="JCM18909_1814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015128">
        <property type="term" value="F:gluconate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003474">
        <property type="entry name" value="Glcn_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30354">
        <property type="entry name" value="PTHR30354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02447">
        <property type="entry name" value="GntP_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002746">
        <property type="entry name" value="Gluconate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00791">
        <property type="entry name" value="gntP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="410" mass="41885" checksum="DCDC54502FC4BEAF" modified="2014-03-19" version="1">MTIGSLVVGAIAKLSLSEILASYSKGVGSTVASVGVLIALGAIIGKLLADSGGADEIVDTLVSRASPATLPWAMALIGAVIGLPMFFEIGLVLLVPVILLVTRRSKLSLMRVAIPALAGLSTMHALVPPHPGPLAAIGLLKADLGITLGLGVLIAIPTVVAAGPLFSRLAARWVPADAPDLFLNSDENGRCGIAPGRPRFSVTLMTVLLPVVLMMGKALADIFALKGTAVHSILDFLGEPMFALLLTTLLAIFTLSKASGMNRDAMSNSVGAALPPIAGILLIVAAGGGFKQILVDTGIAKLLGNGITQSSISPLLMAWLVAVVIRLATVTAAGILEPVAASLPPAHAALLVLAIGCGSVFFSHVNDAGFWLIKEYFGISVGQTIKSWSLMETALSVCGVLLVLLVSVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU6</accession>
    <name>W4TJU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68703">
        <property type="protein sequence ID" value="GAE68703"/>
        <property type="gene ID" value="JCM18909_1854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="48"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="29297" checksum="0C136F2B1C8A6D13" modified="2014-03-19" version="1">MPVSDISVAMELRRRRRRKRNRIIAGVVAAVVVLVLVAMWIVRSSSLLCVNTIEVHGTHLVTASQVEQAAKIPKGQPLARVNTDDVAARVTRMDIVQQAEVYRKWPHTVVIDITELKISYQVKTPGGYLWIDPPGGSLTEPQNPLRTWCGQRLHLEIVAYCETSQLSLIPFPPSLDAMLTTSRPHPAMPLSWCCRVGERWCGDRWLNLFSRPRLPQRCSTLRRLVMMSRPPRIRPLAEQSQAAVEGRGQGWLQRWTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV6</accession>
    <name>W4TJV6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68817">
        <property type="protein sequence ID" value="GAE68817"/>
        <property type="gene ID" value="JCM18909_1981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043777">
        <property type="entry name" value="DUF5719"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18986">
        <property type="entry name" value="DUF5719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="323" mass="33716" checksum="356226E21929D274" modified="2014-03-19" version="1">MSDRPRRALADDEEPEEIPEVRFVEEGAIPARRAAGSEDVSDQPTPHAARAMAQVPAFDEDSYDELTEPDKKAGRYWKGPVWAVTLAVVAVAMSLATSAIPPMQRSAAKVQPISSGRTLVCSPSQGKASLAAGSSGGSLQVGTSVEKLSEASVPVMTNVGTSAGYIRSTAGQRRPSGSALSSEGGMTTWVPCIGAATGGAVSVTNPSTSDLVVVNSDIRAATVDVTMLGSKGEIVTAGMRGIRVSPGQTKVLPMSVWDNGTTPVTALVNAREGRVVVGARMWAGQGRDTSAMTQAAKTLFFCQLSLPRYRLQPLSFRIPARDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV9</accession>
    <name>W4TJV9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_1871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68718">
        <property type="protein sequence ID" value="GAE68718"/>
        <property type="gene ID" value="JCM18909_1871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="13"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="471" mass="50183" checksum="C6F07F07A377C54A" modified="2014-03-19" version="1">MGESTTKRVGSHYVLDDVLGRGSMGTVWRGHDLNDGSPCAIKILNPALTTDKGATRRFIDERDIFMSVDDDAVVRVTDMVVESSTFAIVMELVDGPDLAQVLKSLPDHRLDQGTAVSLGIEICQALAAIHRVGIRHLDIKPANILIEDPENVSGARITDFGVSEVVAFHGPREVVGTPYYQAPEVAAGWTPTAASDLYSCGVTFYEILAGHMPFQANSAGNLLRNQPPPAIPGIDPRLWNTILTCLAPDPSQRPDSAEVLATELRSWRNGEQPVRLVSPRSQPVRPTPQPMPRPQPVRSTPSAISGATPPAPSATSVATQQRGSGWVIALLAVLVLVGAGVFFYVKGMPGSHSDAAPQPTQAPISTSTPEVRPTRTVTAHATVTTMSSPIQIQLPGGAVECEQGAWIANPRTTCALALEVVRSVPANHPASFAIDAQDPRTGKSRHFSCNTVGQYVDCGSQDLEVYLVIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW7</accession>
    <name>W4TJW7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopolyphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69091">
        <property type="protein sequence ID" value="GAE69091"/>
        <property type="gene ID" value="JCM18909_2275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="34"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="310" mass="32825" checksum="78DB66B5BAED969C" modified="2014-03-19" version="1">MSGSHTVAAIDCGTNSIRLLIASADSDGRVVEQSRELEMVRLGQGVDATGSFRSDALERTFSACRTFAQAIADHHCDRVRFVATSAARDVSNRDAFFAGVRQALGVDAEVIDGVEEASLSFAGAMSGIQVIDEPVLVIDCGGGSTELVLGRGTSIDSRVSLNIGSVRLRERFLHDDPPTVEQIDDARKYVREALDSCPVDVAAARTVIGVAGTVTSLSAINQSLTEYDRAKMHRSVLTVGQISDLAGKLLSSTVDEVEQMGPLKRRRAEVLCGGAVIIDEVCRRATAGKLVVSETDILDGMALAMLAQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK46</accession>
    <name>W4TK46_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69325">
        <property type="protein sequence ID" value="GAE69325"/>
        <property type="gene ID" value="JCM18909_2529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="208"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="390" mass="42763" checksum="BEFA7786BC3046EF" modified="2014-03-19" version="1">MGRAFDRVIIIPVQAGPNDAQTRAIPSNAQVMHIARSSPRGLDRALVAVKGLVQLPPSGVDWAATRRQPRLLVSDAHFEGRAQTALDGILAKLPSLRLTPESHVTIYSFWLHITARTATLLAEQLRAQGVTVDGVISRAHRYDLYPSVAPRHHIPERRLLLQSLDGICPVSEQGTRELQTTWPQYAGKIHTRYLGTSDPGPTAHCRRDPFTIVSCAHLVPVKRMIRMPAILARVRANGIDAHWTHLGDGPQMDTLREEVAVHRVTDAVTLLGHVDNTQVMATQRDLKPSVFVNLSSSEGLPVSMMEVASLGIPIIATGVGGVGEIVSSDNGHLLPAEFTDAQASDALVQLARLSEDEYQQVCQASRQVWEEKFRASIVYPEFCREVLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK72</accession>
    <name>W4TK72_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prephenate dehydrogenase</fullName>
            <ecNumber evidence="4">1.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:13869"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69201">
        <property type="protein sequence ID" value="GAE69201"/>
        <property type="gene ID" value="JCM18909_2394"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18248" checksum="A90BA6D3A3FDB937" modified="2014-03-19" version="1">MSILTAANLRRARPEHLSLAGPGIRDVTRIARSQTAMWRQILSSNCVEVRSQLEAIRDDLDDLLSRLNDSERLEEFLSVGQAGARKVAGKHGHQMVETTAVVVEIPDTPGALARLFADVEAAGINVEDLSVEHNPAREAGFLSIDVAPSRAEQLTTSMRDHGWSVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK80</accession>
    <name>W4TK80_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68912">
        <property type="protein sequence ID" value="GAE68912"/>
        <property type="gene ID" value="JCM18909_2085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5973" checksum="9242EFA8A8ED52AE" modified="2014-03-19" version="1">MGSVQPGGWGHALVERLNEVVDLRGRKRGLTSCFLHRVDIPDSSGRQGCHDQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK95</accession>
    <name>W4TK95_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69370">
        <property type="protein sequence ID" value="GAE69370"/>
        <property type="gene ID" value="JCM18909_2579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10637" checksum="2FDA755C6D5FB3EC" modified="2014-03-19" version="1">MMSVVTSVASDTTSVVTMIIVILTGMIFMVMDTPQMHDRLRMAGSRKPDVVLALESFASGIRKYWLVTTVFGLLSPSLTGQLCSSSTFRLPGSGRCSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC3</accession>
    <name>W4TKC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteinyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68962">
        <property type="protein sequence ID" value="GAE68962"/>
        <property type="gene ID" value="JCM18909_2139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="6">
        <location>
            <begin position="26"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="249" mass="28255" checksum="E6A02BFDBC0425FD" modified="2014-03-19" version="1">MSGYTGNLSHVTFKLYNTATHGIETFKPLREGQVSIYHCGMTVQSSPHLGHIRKEVVFDVLRRWLECSGYRVTVVANVTDIDDKIFAKSAAAGTPWWAHAYHYENELHAAYKALGCRPPTYEPRATGHIPEMIELVKTLIEKGHAYPAPDGSGDVYFDVRSWPRYGELSGMRVDDMSPAEDSDPRGKRDPRDFALWKGHKEDEPETASWVSPWGRGRPGWHLECSAMSGKYLGEVRYSRWRYRLAVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC4</accession>
    <name>W4TKC4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="10" type="ORF">JCM18909_2604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69395">
        <property type="protein sequence ID" value="GAE69395"/>
        <property type="gene ID" value="JCM18909_2604"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="8">
        <location>
            <begin position="43"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="9">
        <location>
            <begin position="228"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="528" mass="58938" checksum="4D67CE99ABDAE4BA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF0</accession>
    <name>W4TKF0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster regulator SufR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69410">
        <property type="protein sequence ID" value="GAE69410"/>
        <property type="gene ID" value="JCM18909_2620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20221" checksum="91F6B8A225E560B5" modified="2014-03-19" version="1">MKNSTDTEVAVAGRDIVGEHKQETADSPTRDRVMSSILHNGPSTASELADRLGLTAAAVRRHLSALVSQGLVDSREKKVFGARGRGRPSRVFFLTDHGRADYYTAYDDLAISALRQLADAAGPSALDAVAKVESMTLSRVTERCVRRAPTKSRLSCWLRCCRPTAMWPPFNQLVRGNRSVNIIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM7</accession>
    <name>W4TKM7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="13">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">kdpB</name>
        <name evidence="14" type="ORF">JCM18909_2552</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="13"/>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69346">
        <property type="protein sequence ID" value="GAE69346"/>
        <property type="gene ID" value="JCM18909_2552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 13" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 13" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="347"/>
            <end position="354"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE69346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="662" mass="69206" checksum="3ADEAE71C59BB2C4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT4</accession>
    <name>W4TKT4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68769">
        <property type="protein sequence ID" value="GAE68769"/>
        <property type="gene ID" value="JCM18909_1926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031553">
        <property type="entry name" value="tRNA-synt_2_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16995">
        <property type="entry name" value="tRNA-synt_2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2_TM" evidence="10">
        <location>
            <begin position="33"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="LPG_synthase_C" evidence="9">
        <location>
            <begin position="269"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="414" mass="45012" checksum="BCFAF1CA92CC82E1" modified="2014-03-19" version="1">MTSSDPVPETRAASAARPRTGSRSTSNPRSTPVVVIPRLMNIAALLIVLRLVFSRTAWVAIANNVFSLFIFPVDGFGWAGVVVLLVLSDALSRRKRFAWWVSLVVFGLMWLVAAAFFIIVVTEVFIGWPTDTLNDVDLAGYLFNVFSVGWILVALLTHRRGFAAHTVRANLGRAVVVLVGGLLATGFIGWLLVSLTGGVGRPRNRLVHIITRILQGNGAGIAQEPTSPHWVQGVVSFLLAVVLVAALVVTLRSQRNIAMMSLSDELRLRRLLDENPADSLGYFALRRDKAVVFSRNGHAAVCYRTEAGVALASGDPVGPVDQWPGAIDAFLEVAHTYGWVPAVVGTSEEGATTWNQAGLRAMRIGDEASSPRLRLISMILISSRCAIRSRNCARWDTRLGFDAMRTSIRRSCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW3</accession>
    <name>W4TKW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylaminoimidazole carboxylase ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68799">
        <property type="protein sequence ID" value="GAE68799"/>
        <property type="gene ID" value="JCM18909_1962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="4766" checksum="3670119B0A885EBB" modified="2014-03-19" version="1">MNVVTSYTIGIIGGGQLARMMHQAAIGLGCAPACWPLILTILRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY7</accession>
    <name>W4TKY7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69625">
        <property type="protein sequence ID" value="GAE69625"/>
        <property type="gene ID" value="JCM18909_2864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="278" mass="30073" checksum="F3BA169A02344789" modified="2014-03-19" version="1">MSAKVLLSTEHLYATHPGRPMVLTDVNVSFRAGVRVAILGANGSGKTTLMRCLSGSLKPAKGHVTRGDTVVGYGRAQLREHRRAVQLVLQDPDDQLFSADVSQDVSFGPMNMGLNVDEVRDRVSESLELLGASHLAERATYQLSYGERKRVAVAGAVAMRPDLLLLDEPTAGLDPVGVPQMLEALDRLRDHGTTVAMATHDVDLALAWAQEALVVVDGQVHQGPIDELLADADMVGRAHLHLPWPLELARRLGVRDLPRTMDEVVAMLSDNPSPVPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL00</accession>
    <name>W4TL00_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68839">
        <property type="protein sequence ID" value="GAE68839"/>
        <property type="gene ID" value="JCM18909_2004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6799" checksum="8C51C1EAAADE4642" modified="2014-03-19" version="1">MASYCQCAAWHDGRQARIIDQVTADEVARAAREELDAEEECVYEWLGLVVEVLVEVELSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL04</accession>
    <name>W4TL04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68844">
        <property type="protein sequence ID" value="GAE68844"/>
        <property type="gene ID" value="JCM18909_2009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10208" checksum="3EFE1548D1AA1A85" modified="2014-03-19" version="1">MPLSSLAAGQNATIEDITIDCADYIRRRLHMLGFAHGRAVTKIRQAPFGGPMVFHVCDVQMCLRRAQADMIMVRPAPQTAPQPVVESCATTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL22</accession>
    <name>W4TL22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68864">
        <property type="protein sequence ID" value="GAE68864"/>
        <property type="gene ID" value="JCM18909_2033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20302" checksum="6CF451DFB27F0BB6" modified="2014-03-19" version="1">MPAWADDDGVEQIPTALADQWHAGWCNKSEEGYSVLIDLASLDPKDRGDLNPTTTSYTDAHVKDGWFVRCHKGLEPVKYAPSGEWAAEYQSANWAASVGVPGTRDANGWYRFLGITPGGDETPDGDLILAGALTVVPDKDGVLPPWPEKVVEGESYPGAPINDPDVVPSMTAKPVKGMAVAIAFEPEGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL71</accession>
    <name>W4TL71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69481">
        <property type="protein sequence ID" value="GAE69481"/>
        <property type="gene ID" value="JCM18909_2700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="8"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18096" checksum="45DD74CB091BBE04" modified="2014-03-19" version="1">MSAARMLGRPVDRIVVTHHHYDHSGGLPGITDAEVWMHEAALAHCPDLHVDHPVSLMAYVNLGGLGAEVIHPGPAHTDGDLIVIVRDEKITFVGDLVETAGEPQSDETTDVRGWPRAIDSVITGTDGAGIYVPGHGQPIDATGVMNQRAQLAERIPTNIPLTDRHLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK6</accession>
    <name>W4TLK6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sulfur carrier protein adenylyltransferase ThiF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69044">
        <property type="protein sequence ID" value="GAE69044"/>
        <property type="gene ID" value="JCM18909_2226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="38"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="281" mass="29762" checksum="47081E65E64C238E" modified="2014-03-19" version="1">MSAPNPMDDAVSRAINGHDAVEDLGPTASLINRDLIRYARHIVLPGFGQEAQRRLRDSRVLVVGAGGLGSPVLLYLSAAGVGHLTILDDDVVDESNLQRQVIHRQVDVGRPKALSAKDAVQRLNPYLVAEAIVARLGTDNALDLVKDHDLILDCTDNFTTRYLASDAAEITGTPLVWGTILQYQGQLSVFWPDRGPMLRDLFPEVPAADSVPSAVVGGTFGPVVGQVGSMMTTEAVKVLTGIGTPAVGKLVVVDALGVGTRTLSFAADPDRASVTQLPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL3</accession>
    <name>W4TLL3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_2236</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69054">
        <property type="protein sequence ID" value="GAE69054"/>
        <property type="gene ID" value="JCM18909_2236"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="13">
        <location>
            <begin position="31"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="14">
        <location>
            <begin position="331"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE69054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="527" mass="59105" checksum="FD222440C6E3C28B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP7</accession>
    <name>W4TLP7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69353">
        <property type="protein sequence ID" value="GAE69353"/>
        <property type="gene ID" value="JCM18909_2560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8092" checksum="7C07440EB1AA59D4" modified="2014-03-19" version="1">MDVPSRPYGRPGDIGAVIHDHPRRGVRSTNRLADLQNQAEQITSDNSLARTCTIPAPAPAAAAAVSTVCRSVPDVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW0</accession>
    <name>W4TLW0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-succinylbenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69736">
        <property type="protein sequence ID" value="GAE69736"/>
        <property type="gene ID" value="JCM18909_2985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041338">
        <property type="entry name" value="OSBS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18374">
        <property type="entry name" value="Enolase_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="1">
        <location>
            <begin position="82"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="247" mass="27001" checksum="905EAE51BD7B194F" modified="2014-03-19" version="1">MLADRGIDRMLAFAVPLTVRFRGIEVREGTLLHGPEGWGEWSPFWDYDPVESASWLRAGIEGATRRLPVARRDRVPINVTIPVVDADRARRMAAESACLTAKVKVADPRSDLCEDCRRVAAVREAMPDGHIRVDANTAWDVDAAVRAITELDAAAEGLEYVEQPCASVAELAQVRRKVNVPVAADESVRRAEDPLAVARAGAADLLIVKAQPLVELPEPLRSSMLPGYRPSSPRPWTPVSGSAWLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW2</accession>
    <name>W4TLW2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69955">
        <property type="protein sequence ID" value="GAE69955"/>
        <property type="gene ID" value="JCM18909_3228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16783" checksum="4634E695D84369FC" modified="2014-03-19" version="1">MRPTEEGGVDEIHMVYTEFESMLTQTPKVIRLLPLAVVDPQDTPEGQLAEGDPGVGANAEEIFHEYRFEPDPVSVLDELLPLYVANRVHYALLQSAASELASRQRAMKAATDNAEQLIQTLTRQANQARQAAITQEITEIVGGAAALAESAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM26</accession>
    <name>W4TM26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major myo-inositol transporter IolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69582">
        <property type="protein sequence ID" value="GAE69582"/>
        <property type="gene ID" value="JCM18909_2816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="394" mass="42896" checksum="D857BF07D795884D" modified="2014-03-19" version="1">MNEIPLSEIPELVARTPPSGKKRSIALLAAVATFGSLLFGYDTGVISGALPYMYLPRVAGGLALNSFEEGLVGGILAIGAAFGAIIGGQLSDRYGRRHNILMLAIIFIVGTVGCTLAPNIWVLYPFRFVLGWAVGGASSTVPIYLSENAPKRIRGPLVAVDQFMIVTGQLLAYTMNAILSSSHGGPRVQVDHDPSGEFSHGQWAAWDAVGRINDITVMAGNGQAWRYMLVLATIPAVCLWIGMRMMPESSRWYAANGHLMESIGALKRIRDEDKDDVADEIKQMVEINRVEAHEEEWTLSQAWNIKWTRKIILIGCFLGFFDQLTGINTAMYYLPKILESAGFSAASSIELNVITGLASCIGAAFGLCWSANSCVGMWASIRRQECHCRCSGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM67</accession>
    <name>W4TM67_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70075">
        <property type="protein sequence ID" value="GAE70075"/>
        <property type="gene ID" value="JCM18909_3360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015577">
        <property type="term" value="F:galactitol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013853">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37324">
        <property type="entry name" value="PTHR37324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17385" checksum="ECA59B1F65EFA3A5" modified="2014-03-19" version="1">MTNVLNVDIWNLIHFLVPGTLAYALTNNAWIGLGVVLVLSVIDLIVAQHIAPKWQEYYGLTGTTCSTLSYITSAWPIAIGLNWVIDKIPGVLKIDISMEKFGDRLGFFGDTASSAHRWHLPGTHDPSTLAGCPRHGYGNRHRSGAPTSNGLGHDGGPVDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM83</accession>
    <name>W4TM83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69836">
        <property type="protein sequence ID" value="GAE69836"/>
        <property type="gene ID" value="JCM18909_3092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7292" checksum="72A9A6529C41AF79" modified="2014-03-19" version="1">MNKIPTKKNPVTVYAGGGGGKRASGSVSCRSHKPTWYHGQVDVDIIDAIDTSNRPNSHDVELNCQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA4</accession>
    <name>W4TMA4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell envelope-related function transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2765</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69538">
        <property type="protein sequence ID" value="GAE69538"/>
        <property type="gene ID" value="JCM18909_2765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="257"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="527" mass="57760" checksum="32CA2C2577940BF4" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC3</accession>
    <name>W4TMC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69558">
        <property type="protein sequence ID" value="GAE69558"/>
        <property type="gene ID" value="JCM18909_2787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="7990" checksum="8D4378E2CEF800DC" modified="2014-03-19" version="1">MINPILRQLRPTRRVSALLRWEGIVVDPLGAILALLVYQAITSIDGSSIGKGVLNLGLTLLVGLLFAGPIGGSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME7</accession>
    <name>W4TME7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69364">
        <property type="protein sequence ID" value="GAE69364"/>
        <property type="gene ID" value="JCM18909_2573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021299">
        <property type="entry name" value="DUF2871"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11070">
        <property type="entry name" value="DUF2871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16769" checksum="724EA5D129F7FF9C" modified="2014-03-19" version="1">MTPLKKLAICATTWLVIGLLGGVFSREFTKAHDFTAWTQLKVVHTHSLALGFMLTLIVLLLERAFTLSHHRGAFATYFWGFNLGLLLTIAMLVVHGMMQVTGHPDVSPVISGIAGLGHIGLSVGLVGLMVALFTSLPRQNRDQLTTTHGPLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH1</accession>
    <name>W4TMH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-succinylbenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69737">
        <property type="protein sequence ID" value="GAE69737"/>
        <property type="gene ID" value="JCM18909_2986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8107" checksum="BFFB4D52EA68367B" modified="2014-03-19" version="1">MATYLAAALPSLDHACGLGTIRLFQGDVSASPLLPVDGYLRPRRGEVDVEVEEPDTDLCPRWSQRLALTVAALVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK0</accession>
    <name>W4TMK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTP-glucose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69772">
        <property type="protein sequence ID" value="GAE69772"/>
        <property type="gene ID" value="JCM18909_3024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="entry name" value="PTHR43511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25991" checksum="88DC56CBC03D34C2" modified="2014-03-19" version="1">MPKDSSLEWCPPGHGDLYTALLGSGVLDHLLEAGYQYASVSNGDNLGAVPDGRLAGWFAASGAPYAAELCRRTINDKKGGHLAIRKSDDQLILRDTAQTAEEEMDYFTDEHRHPFFHTNNLWFDLEALKKVLDERHGVMGLHIIRNEKTVDPKDSSSTPVIQIESAMGGAIEVFEGATCICVDRSRFLPVKTTNELLLLRSDVYDLDDSDHLVKTTDMTCAVDLDKDFYKKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML6</accession>
    <name>W4TML6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH marR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69946">
        <property type="protein sequence ID" value="GAE69946"/>
        <property type="gene ID" value="JCM18909_3218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9723" checksum="AE790FB485A92536" modified="2014-03-19" version="1">MSSGHPIPQHSGPLEAELAADLVLTCGRIQRLAKRRAGIPSSSVTWRVLHTLEVMGTISTGTLSRVEGTRPTTTTDIVERLERDGVSSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN2</accession>
    <name>W4TMN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69802">
        <property type="protein sequence ID" value="GAE69802"/>
        <property type="gene ID" value="JCM18909_3057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9264" checksum="756EF8FCB888EB4A" modified="2014-03-19" version="1">MPDPIRVILVDDQSLVRSGFRMLIESEDDMEVVAEASNGLEALDVLRRMPVDVASWTSGCRRWTVSRPLDASRRPHWIPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ9</accession>
    <name>W4TMQ9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="ORF">JCM18909_2681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69464">
        <property type="protein sequence ID" value="GAE69464"/>
        <property type="gene ID" value="JCM18909_2681"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="16"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="414" mass="45699" checksum="60D658F8D3694238" modified="2014-03-19" version="1">MTFGFEVTSRLDNACGRTGLIHTPHGAIQTPAFVVVGTKATVKALLPESVVQLGAQAVLANAYHLFLQPGPELIDEAGGLGQFMNWTGPTFTDSGGFQVLSLGAGFKKTLAMDVSQLTEADVIAADADRKAMVDDDGVTFRSPLNGDLHRFTPEVSMGIQHHLGADIMFSFDELTTLMNTRAYQEEALERTRRWAERCLAEHRRLTEVRSGKPYQALFFGVIQGAQYEDLRRRACRDLAGMEIDGQCFDGFGIGGAIEKANLGRIVTWCAEELPEDRPRHLLGISEPDDLFAACRAGADTFDCVNPSRVARNAAIYTVDGRYNVDTARFRRDFGPLEDGCDCYTCTHYSRAYIHHLFKAKELLANTLATIHNERWTVSLVDQIRGAMCSGDLDAFETEFMGRWNANGGRLARVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS7</accession>
    <name>W4TMS7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69484">
        <property type="protein sequence ID" value="GAE69484"/>
        <property type="gene ID" value="JCM18909_2703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25097" checksum="C54C61B488F2E70F" modified="2014-03-19" version="1">MIDRYSHDVLASGWRTSHMKKSADMPLELDIVVEDPSSGFVGAVVGWQNGLVVLEDRKGKRKSFPVGPGFWVDGQPVNLCIPPRRGSVNIKHTASGSIAGGAEPARVALPSRIYVEGRHDAELVEKIWGDDLRHVGVVVEYMGGMDDLVGIVAEFKPGPGHRLGVLVDHLVAGTKESRVADEVRRGGYGEYVMITGHRFIDIWQAIKPQRIGRENGLRSRWTKTSNSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU7</accession>
    <name>W4TMU7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69509">
        <property type="protein sequence ID" value="GAE69509"/>
        <property type="gene ID" value="JCM18909_2734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10122" checksum="C1D6A034D4D4E6BF" modified="2014-03-19" version="1">MGEEAVEQLRSGLSAILAAQRHDVAEFSRHVNPDVDPEWLIDGCQEICVALAAHAATIGWQRPEVDVSNVFASLDMVSEPDLVRTLLRQAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN53</accession>
    <name>W4TN53_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69947">
        <property type="protein sequence ID" value="GAE69947"/>
        <property type="gene ID" value="JCM18909_3220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7651" checksum="A6246E3F0772D74E" modified="2014-03-19" version="1">MFTGDQSGDWLYRTLYDADIASQAQSIDAADGLTLHDCRIIAPVHCAPPDNWPRPDETRSALALSGLMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN63</accession>
    <name>W4TN63_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70171">
        <property type="protein sequence ID" value="GAE70171"/>
        <property type="gene ID" value="JCM18909_3468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="204" mass="21816" checksum="4BB4EA940C024F8E" modified="2014-03-19" version="1">MAKHFTQLAASQGRQVDSVIRRNDQAHDVTLWGGNPVVTDVTTLRPSQWDDLISNHDAVVWSAGAGGKGAPEDTYAVDRDACTALVDAIGRSPHGPHFVLVSWCGSPNHGVPSDNSFFPYADAKAAADRHTMDSSIRWTILGPVTLSHDPASGVRILTEGEEYAGTTVSRETVAQAALACLDDDTTTGKFIRFCDGPRPIAEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN70</accession>
    <name>W4TN70_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69659">
        <property type="protein sequence ID" value="GAE69659"/>
        <property type="gene ID" value="JCM18909_2904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037493">
        <property type="entry name" value="ExoIII-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43250">
        <property type="entry name" value="PTHR43250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="13254" checksum="3B31402842543D80" modified="2014-03-19" version="1">MGDFNIAHENADLKNWKANQHNEGFLPEERQWFDTILSPDTLIDVVRAQHPDTNGPYSWWSWRGKAFVHDAGWRIDYHLASPELASKAITSEIDRDPSYSERTSDHAAVVVDYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN71</accession>
    <name>W4TN71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70181">
        <property type="protein sequence ID" value="GAE70181"/>
        <property type="gene ID" value="JCM18909_3478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9639" checksum="E68E0384A3820B8F" modified="2014-03-19" version="1">MWRLNSSLGYGDVRLAAGTGFLGATTAVLSPYPDFVRTGMTTLLSSTILGTVVAVIVTLVRKHRPSPWGSAFAYGPALWAGPWMALAISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN78</accession>
    <name>W4TN78_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="9" type="ORF">JCM18909_2914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69669">
        <property type="protein sequence ID" value="GAE69669"/>
        <property type="gene ID" value="JCM18909_2914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="227" mass="24707" checksum="EF1A50A9BBC3F824" modified="2014-03-19" version="1">MTDEKRNLSDGDDPSVKGELSPRGEDLASNNLPETDEYDVVDPEAEELTTPDDVVDKTPDKADPEDMVIDDPDQLEGAEEVAASARSSRPVRKKDSAGKPARRGKPVRKEASAADEEPATASAATSAGPKPKRKLTKAPVRKESSHHKPADQGKQRIGPVTFTKQSVAELRKVKWPSGDELGQYFLVVLFFVLLIIAYVSGLDVVFGWVVIKLFLATDDHIGELTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB8</accession>
    <name>W4TNB8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamin-phosphate pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69709">
        <property type="protein sequence ID" value="GAE69709"/>
        <property type="gene ID" value="JCM18909_2958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP-TENI" evidence="2">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19077" checksum="8A5D981AAAC1C28D" modified="2014-03-19" version="1">MSGEGSAMSRPEFDLSVYLVTDTAQCGGPDEVVETVRHAIAGGVTLVQFRDHDLSDDEFVALGRRVREICVSGGVPSSLMIAYISLPKLGPMVPMLGSLTCRSTRPVRFWATIYSSACPLRLPPMWRPPCPRGVTSSTIWELGPCTALEPNLRLGSSAWLGYAMSSTPARGRCASSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNE9</accession>
    <name>W4TNE9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69913">
        <property type="protein sequence ID" value="GAE69913"/>
        <property type="gene ID" value="JCM18909_3180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043839">
        <property type="entry name" value="PafC_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19187">
        <property type="entry name" value="HTH_PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_PafC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="151"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="262" mass="29274" checksum="C61EDD27128F8671" modified="2014-03-19" version="1">MTARTDTARLLALIPYLRSHPGVAVTEVARVFGVSTDRVIADLKILWMVGLPGGMPDDLIDIDMDAVDSDGTITITNADALPRPMRLTPDEAWSLLAALQVIADLADDTVRPAVESAVEKLRQVCPQAGPDPVEASLEADYDPRSEWFTGACANKWRIEIVHRRGDDPTPHTQIVDPVRVEVRDGHRYLVGWSMARKQWRTWRLDRIVTGRRVGHATNHGRPPETLEWFSDVVDEVTLTLAPRAGWVAEYHPVRHVEKDGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG0</accession>
    <name>W4TNG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MutT/Nudix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70495">
        <property type="protein sequence ID" value="GAE70495"/>
        <property type="gene ID" value="JCM18909_3822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6345" checksum="B8DAC1C7C7F1D0E0" modified="2014-03-19" version="1">MIMTMIIERVADSWLAIPATRWSLADAPAEAMTDRSVAEATVPDPLDDRETLGWGTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH3</accession>
    <name>W4TNH3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein hemolysin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70291">
        <property type="protein sequence ID" value="GAE70291"/>
        <property type="gene ID" value="JCM18909_3599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6387" checksum="796B1F0C20CEB4BB" modified="2014-03-19" version="1">MATGCSNKTKNRSSVLPQPRLRGWVHTVMAPLILLAGVGLMMLRRPGETDLPLGCGCLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ8</accession>
    <name>W4TNJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70311">
        <property type="protein sequence ID" value="GAE70311"/>
        <property type="gene ID" value="JCM18909_3623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="436" mass="45060" checksum="BDDC5E296EED1F36" modified="2014-03-19" version="1">MRHGMEVPDSFMGLYGAALMRSQEPGVNPGLLRSGDGDDVGETTGSDPGKGRPRVIRSPKAPCMAPCRSDLASRSSHQEGTVMPSSRRSVERDRRLPVAPLLLVLVVLIVVSAVISLAIGSEPLPLRGVLDTVGARVTGQPGPDPTIDVIVWDLRAPRALLAVIVGAGLALAGSGMQTLVRNPLADPYLLGVSAGASVGATAVIALGMFTSWGTHRLTLGALVGALAAAALVYLISMAQGGMTPLRLVLSGVVLSSAFSALASFLVFRSPDPRAAQSVLFWMLGSVAGATWDSLWVAALVTVVIAVLMIAFSGWLDALAAGTDVARSLGIPDTRVRKALFVGNSVLVGVLVAVSGGIGFVGLVIPHMARLLVGASHRSMLPIAAAVGSLFLLWVDVGARVIAAPQEVPLGVVTGFIGAPIFLYLMGRSQYRFSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL8</accession>
    <name>W4TNL8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69804">
        <property type="protein sequence ID" value="GAE69804"/>
        <property type="gene ID" value="JCM18909_3059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12718" checksum="3BDD99622D57616C" modified="2014-03-19" version="1">MQLTKIFGEGETRVTALNSISVRFTRGTFTAIMGPSGSGKSTLMHCLAGLDRITSGQVFLAGMEISNLPDAKLTTLRRDNVGSSFSRSTCCRCSPLRKTSCFLWTWPDASLTGRCGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN0</accession>
    <name>W4TNN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70570">
        <property type="protein sequence ID" value="GAE70570"/>
        <property type="gene ID" value="JCM18909_3917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14386" checksum="45D01E8EE5303A17" modified="2014-03-19" version="1">MNPRHTRQTDLRYSRRDAMSPNRARRARRVTIGVTVLLVAVLVLAACRLAGVLIFDWLGNGAFNSQQYAQAEQYYGANMKLNVIEPWIASYDRGTSRAAESNYADARRIFVPHSTWRRRSRSAGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT6</accession>
    <name>W4TNT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70202">
        <property type="protein sequence ID" value="GAE70202"/>
        <property type="gene ID" value="JCM18909_3500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10539" checksum="AB3FE1F20EC14E25" modified="2014-03-19" version="1">MGMILGHAPIILPAVLQVRLKWTTWFWLPAFLLEASLLVRIGIGDGLDRSAAVQAGGTVNVLSLLTLVAVVATHIRPRNRAGTHPKSTPRSRSGEDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP95</accession>
    <name>W4TP95_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein OppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70019">
        <property type="protein sequence ID" value="GAE70019"/>
        <property type="gene ID" value="JCM18909_3299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="14"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="353" mass="39090" checksum="7FE71C99AC9EAD16" modified="2014-03-19" version="1">MTVKTTADKAGPILSVRDLTKHYPLKSGVVRHTVGYVKAVDGVSFDLSPGETLGVVGESGCGKSTLGRLLVNLEPPTSGTITFEGRDVTNLTGSVMRKLRRDIQIVFQDPYTSLDPRMTVGDIVGEAFRIHPDAVPRRKRTEQVKELLDLVGLNPEHINRYPHEFSGGQRQRIGIARGIALNPKVLVCDEPVSALDVSVQAQVVNLLQKLQRELGMAYIFIAHDLSVVRHISDRVAVMYLGRIMEFGDEEQIYERSTHPYTQALLSAVPVPDPSARGMRHQILIHGDVPSPANPPSGCRFHTRCWRAQPLCSDKETTLTMHADGQGEHACRCHFTEIFEKASDDISPVFRKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPA9</accession>
    <name>W4TPA9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70362">
        <property type="protein sequence ID" value="GAE70362"/>
        <property type="gene ID" value="JCM18909_3678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="131" mass="13914" checksum="93F43CB1B92AE151" modified="2014-03-19" version="1">MEDAWGRCDDNPSLPSGIKVDVIKTSGALTDDLKVLALTNHLGVEGIGQARQYGVGGGDLAGQFLAVHEVVAAYDLVTGEFLVNDGHELRCGDNDAGHSITVGDRTTGTQRVAKKLMQYATIPLCRCRGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPE9</accession>
    <name>W4TPE9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70397">
        <property type="protein sequence ID" value="GAE70397"/>
        <property type="gene ID" value="JCM18909_3715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8178" checksum="38A7B3155B28303D" modified="2014-03-19" version="1">MGNQLARELIDVFWDSLNLAGLMLPPTNTMPATRHAHDLIADCVIGHDPQASREAMWDHFAAIRERLGGAPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPG3</accession>
    <name>W4TPG3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70616">
        <property type="protein sequence ID" value="GAE70616"/>
        <property type="gene ID" value="JCM18909_3970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8419" checksum="70308AF2A2613D71" modified="2014-03-19" version="1">MAKICNAVTNLVTITTLAIHGHVWWHIAWPLVVSNVLGGLIGARTAMKHGNGFVRTMFLIVTSVLAVRMLVQLIWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPN0</accession>
    <name>W4TPN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70179">
        <property type="protein sequence ID" value="GAE70179"/>
        <property type="gene ID" value="JCM18909_3476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="13"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="15632" checksum="42BE4DD9479ECFE7" modified="2014-03-19" version="1">MGDKHGELSGALKILVYSDDHTVREQVKVALTGMIAPDLPRAEVVETATQASVVDAVSSGHYDVLIADGESAPYGGMGVCHQLKDEVDNCPPVVLLVARVADAWLASWSHADAIATHPVDPVALPQTVASVIRGIRGDAAEPRETAGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPP9</accession>
    <name>W4TPP9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltose/maltodextrin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70383">
        <property type="protein sequence ID" value="GAE70383"/>
        <property type="gene ID" value="JCM18909_3701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="89"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="264" mass="29369" checksum="6DE21EF51788DA3C" modified="2014-03-19" version="1">MITGSELSAVEVAALAKRGNTVSQRRFVGVHILLLLGGVLMVFPFVYQILMSLSTNMEIQSVPPKLIPDRWQFHNYADVFTRLPFLKQFGVSVTITVLRTVVQLILCSMGGYAFARMKFGGKSVLFGLVLAILMVPGQSYLIGQYEIIRELGLLETPWGIVLPGFFSAFGVFLMRQSFMSLQAELEEAARLDGCNPWQTFWRVMVPVVKPGLFAVMITTVLWSWNDLLWPLIVTTREESMPLSVGIATLAGQHSSEFALMMAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPW2</accession>
    <name>W4TPW2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70572">
        <property type="protein sequence ID" value="GAE70572"/>
        <property type="gene ID" value="JCM18909_3920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="6767" checksum="545E83DAD4003B47" modified="2014-03-19" version="1">MHSTAVADADAVGCPKALVAGAQHAITVTIATTTRETAAAQGSALARRKYFMDHAPSHGEHHTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPX1</accession>
    <name>W4TPX1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70423">
        <property type="protein sequence ID" value="GAE70423"/>
        <property type="gene ID" value="JCM18909_3741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6112" checksum="47A2D82EA4C3FDA7" modified="2014-03-19" version="1">MRGGIAFRVCFFVGGHRGAFVGGHRGAFVVVWGSQASPMPSWSVSVWSWLAMVGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ39</accession>
    <name>W4TQ39_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltose/maltodextrin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_4020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70652">
        <property type="protein sequence ID" value="GAE70652"/>
        <property type="gene ID" value="JCM18909_4020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="16022" checksum="B9A19F8FA90FD0A4" modified="2014-03-19" version="1">MLPIIGIVLIVIYCLAPFYWMLVSSLRPDSEIFDNTWWPAHPSMENYQAVFQPSNNFLRGLLNSLIVSVAVTVIALLIATFASYALARLDFRGKGGFLILIIATSMFPLVAIIVPLLKNFSAWHWINTYQAMIIRTCRSPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQI3</accession>
    <name>W4TQI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000063">
        <property type="protein sequence ID" value="GAE70668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70668">
        <property type="protein sequence ID" value="GAE70668"/>
        <property type="gene ID" value="JCM18909_4043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10646" checksum="15820CE721191E5E" modified="2014-03-19" version="1">MNAADEELKSTFDAAKKATQDRIATWNHKTVAWQEDSQTLIPNHALRVRRTSVEEEKQLIADMEPQQRLARPLLVVVPENYPTAHEECAHAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQK9</accession>
    <name>W4TQK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional repressor of the fructose operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70514">
        <property type="protein sequence ID" value="GAE70514"/>
        <property type="gene ID" value="JCM18909_3845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="253" mass="26934" checksum="49A76BBDDFF8A82C" modified="2014-03-19" version="1">MYPAERHKWLIDTARETGRVSVAEASTALGVVPETIRRDLDQLCNQKMLRRVHGGAIPIEFDLLGDQPLATRDSSAVTQKEQIARAALSHLPSDKGSIILDAGSTTGRLASIMPSTRRFTVFTNSSPIASTVATHSNCDVHLLGGRLRPTTQATVGNVDAISRLRVDVAFMGTNGISPTHGLSTPDADEVATKAAMVASAHHVVVLADSRKMGAESTMRFAELGDVDVIITDSGVTPHQVEMLHKAGVEIVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQN2</accession>
    <name>W4TQN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000088">
        <property type="protein sequence ID" value="GAE70718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70718">
        <property type="protein sequence ID" value="GAE70718"/>
        <property type="gene ID" value="JCM18909_4104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9745" checksum="78236B3D2F999226" modified="2014-03-19" version="1">MGAAGRPTAGNSSRTSSKAVARDLLVHAMTLVAQAGHKIVMHVHDEIVIDEPEDSGFTIADACQLMTTPPDWAAGLPLDADGYECDYYRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEE0</accession>
    <name>W4TEE0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-deoxy-D-xylulose 5-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67151">
        <property type="protein sequence ID" value="GAE67151"/>
        <property type="gene ID" value="JCM18909_192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="345" mass="38182" checksum="3A28B85732B501C7" modified="2014-03-19" version="1">MTIALHRVFDSPHDPIIFDTGHQSYVHKILTGRANGFEKLRQRGGLSGYPSRAESVHDWVENSHASASLSWAEGMAKGFLSQGEDRTVVAVIGDGALTGGMAWEALNSIADQQGLRLVIVVNDNGRSYTPTVGGLANQLAIIRTDPHYEEALDRMKRHVTDKPLGKQVFGLMHAAKAGVKDALIGNGIFSDLGIKYLGPVDGHDVPSVERALELAKRYGHPVIVHVMTTKARDLLLLRLMRRIIFTLSEGLTQSLVHLLRLPAARRGPRLLLAPWLSWGRAPRYCRGDRRHASPRRSRTVRSPTPGSDSRCRYRRAACGDICCWHGRRRVTPRCGSLLDLPQSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEX3</accession>
    <name>W4TEX3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67341">
        <property type="protein sequence ID" value="GAE67341"/>
        <property type="gene ID" value="JCM18909_389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5554" checksum="47D4C46CC813AB40" modified="2014-03-19" version="1">MRAIFGTATPAHKMAILLLGSDTTNVEVQIVEPDGDLMALANALDGRSEGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEZ3</accession>
    <name>W4TEZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YbbM seven transmembrane helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_17</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66988">
        <property type="protein sequence ID" value="GAE66988"/>
        <property type="gene ID" value="JCM18909_17"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE66988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="9802" checksum="A63CD6B701D15CB9" modified="2014-03-19" version="1">MVTPWPAVVFFADLREGIGIFEAGLAVGFPRRDAIALVTEPSVTESVLPTVDRTATVGLVTLPGAFVGVLLGGGSALQAGAAQASFSSAFWLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF21</accession>
    <name>W4TF21_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C4-dicarboxylate transporter DcuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67122">
        <property type="protein sequence ID" value="GAE67122"/>
        <property type="gene ID" value="JCM18909_161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015556">
        <property type="term" value="F:C4-dicarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004668">
        <property type="entry name" value="Anaer_Dcu_memb_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36106">
        <property type="entry name" value="PTHR36106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03605">
        <property type="entry name" value="DcuA_DcuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="29258" checksum="5F8EA277C1F38245" modified="2014-03-19" version="1">MGYLEILAVTIPTTFIGCAVGAVVASRQGKDLIDDPIYQEREAKGLVSHNAAVADTGWRPKRTAIPSLVAFLVALVVVVGYATVSSEEVGVLTKPPMTSSAAIMLIMLTTAMIICMMSREDVKQLTTQTTFRAGMSVAICILGLAWLGSMFVNNYMDVLTHAGASILHSAPWFLSVILYLAAPLMFSHAATTVAFMPVVAKIGLSPMVMLACYPAVANYYLLPNYPTTVAAMEMDDTGSTRVGRIVLNHPFVLPGTVSIAVTVLLGAFWAPIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF58</accession>
    <name>W4TF58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-galactose-lipid carrier transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67162">
        <property type="protein sequence ID" value="GAE67162"/>
        <property type="gene ID" value="JCM18909_204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="19873" checksum="D5DE1C7E7DD0364D" modified="2014-03-19" version="1">MARQEALPEPGMLGVFDRSHYEDVLVPRVENLVEEEVWRKRYDLINDFEMNLAARGTNIIKCFLHISPDVQKERLAARLNDPAKYWKYDPGDLDTRSKWAEYIEAYNELLSRCNPDIAPWYIIPSDHKWYRNWAMGRILLETMRSMKLTWPPANFDVEAEKRRLEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFB7</accession>
    <name>W4TFB7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67222">
        <property type="protein sequence ID" value="GAE67222"/>
        <property type="gene ID" value="JCM18909_267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65m" evidence="1">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="351" mass="39188" checksum="6FA04654A81B3EB0" modified="2014-03-19" version="1">MADLGFWRINGGREFHIHGVTGPDEYTTVVNNNLYTNVMARANLIDAAGVIRRMRDEDPLWYEHLCSELDLTEDEVGGWEECAAGMVIPFDDTFGIHPQDDQFLSRELWDLKNTPDNKRPLLLHYHPLVIYRFQVLKQADVVLALFLQGDQFTQAVKLADFEYYDPITTGDSSLSAVVQSVMAAEVGHQEMAMGYFLDALFCDLADTHHNASDGVHVASTGGVWGCLVHGFVGMRNDRENLRFDPRLPAQWTSIKHHMLIGDSHMLVFLERDAITFQILSGHDRDVTVRGELYHIGVEPVRVPLSDQGPLRPSLRVTHPISGLRRADGSLITAEVPGSIAETIVSSPISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFC7</accession>
    <name>W4TFC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67232">
        <property type="protein sequence ID" value="GAE67232"/>
        <property type="gene ID" value="JCM18909_277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="57"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="506" mass="57959" checksum="87D67648A8016205" modified="2014-03-19" version="1">MTHVPCTPAAEIPETLAPTGALGLTSAQLQARLDEIHPVGSIDRTETEWFRTAVFYEVLVRSFKDSNGDGIGDFKGLTEKLDYLQWLGVDCLWLPPFYDSPLHDGGYDIRDYRWIREELGTIEDFKVFLDAAHDRGLRVIIDFVMNHTSDSHPWFQSSRADPDGPYGNYYVWSDTDEAYSDARIIFCDTEDSNWSWDSQRKQFYWHRFFHHQPDLNFEEPRVMEEMLDAVRFWMGLGIDGFRLDAVPYLIEAEGTNCENLPGTHKILKQLRAMVDEEYPGRILLCEANQWPDDVVEYFGNGDECQMAFHFPVMPRLYMGLRHGSRECISDILAHTPHIPDGCQWGTFLRNHDELSLEMVTEEDRHYMWEEYAPESRWRCNLGIHRRLSLLSITTMRRSGYLTPCCCPYPALRCCTTATRLAWGTIPGCLTVMGCVPRCSGMTRRQPAFPLPFQRTFIYLSSAPLATIQSTSMSPARWTTHPPCWCGRAPCSVSATTPSLGPANSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFH7</accession>
    <name>W4TFH7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylglucosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67282">
        <property type="protein sequence ID" value="GAE67282"/>
        <property type="gene ID" value="JCM18909_328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6247" checksum="577C65A6461679FB" modified="2014-03-19" version="1">MRPVLVMTRKSRIMCFLGVDIGGTSVRSLVTDAGGKILGYQRIARVSHEFFVADYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFI3</accession>
    <name>W4TFI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67287">
        <property type="protein sequence ID" value="GAE67287"/>
        <property type="gene ID" value="JCM18909_333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013012">
        <property type="entry name" value="PTS_EIIB_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51100">
        <property type="entry name" value="PTS_EIIB_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11062" checksum="E5C7618985895F66" modified="2014-03-19" version="1">MSNVLLICSGGMSSAIVLKNLEKEFQKLGEPLQAKAVGSGQAQDEISTGEWDLVLVAPQVRNRLKTFQQYADRRGIPICAIPPVAYGPLGGSELVKTVKEHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFJ0</accession>
    <name>W4TFJ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67536">
        <property type="protein sequence ID" value="GAE67536"/>
        <property type="gene ID" value="JCM18909_602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="187" mass="21334" checksum="CAD7B575E3C34480" modified="2014-03-19" version="1">MRSFYIALDDIEPKFHCDADRQKYPNNGDGKWIADVQADYLNRLETEYVKKNGLPPLQTVPTNYSGSGEDPYKAEFGTRLDKDIRVQWTGEGVFSPSITESSVARAAQTYHTKHLYIWDNFPVNDGRRNRLFLNPLINRDPNLYKHIDGITSNPMIEPMLRCPLWLTTATTRGIRPPTMPSVDVSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFK9</accession>
    <name>W4TFK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67760">
        <property type="protein sequence ID" value="GAE67760"/>
        <property type="gene ID" value="JCM18909_842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5_nucleotid_C" evidence="2">
        <location>
            <begin position="65"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20472" checksum="35E43A8AF1D96415" modified="2014-03-19" version="1">MAWNSQQKKLCSTGASIIDPATTPADDPTIAKISSIYDDAKAKSDKAGTTVIGHETAPITTPSNTSDQKFGAEVRDRESTMTNMVADMFKDTLGKDDPNFIGLQNPGGTRASLLDKDITYKQAAQVLPFANTLTTTRITGAQFKKVLEQQWQRAGTARSRHVHTCSSACPRTSPTPTMSPARRANASPPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS0</accession>
    <name>W4TFS0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67283">
        <property type="protein sequence ID" value="GAE67283"/>
        <property type="gene ID" value="JCM18909_329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="53"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="265" mass="27631" checksum="4FDE29443BB60FD5" modified="2014-03-19" version="1">MAQSSVVHVEAAVVGAAGAGPTGNHDVCQSVEKALGAVGLDVTPQVVTDIEIAYWSAAAFGDGSILVAGTGAIAGRFSEWRCVDRRDGAGWLLGDHGSGYWIGRKALRAAAADLDRRGPSTAITRGVVEALGLPHGCTVQDLIGQTKELRPADVASFAQIVLSAQDDKIASIILAAAASELVTTVRSVGAEYVILAGGLLAPSTSHKYQRPNTLRAMVEDSLGECPYASHPVVGACWAAGRLRGVELHKVDLMNALEIRSDSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS4</accession>
    <name>W4TFS4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA recombination protein RmuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RmuC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67377">
        <property type="protein sequence ID" value="GAE67377"/>
        <property type="gene ID" value="JCM18909_433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003798">
        <property type="entry name" value="DNA_recombination_RmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30563">
        <property type="entry name" value="PTHR30563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02646">
        <property type="entry name" value="RmuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="363" mass="39853" checksum="551CF7F1FBC0AEB8" modified="2014-03-19" version="1">MCQTLLGPSWHDEHRGRAYRTSYRCGPGVAHRAIARVPAHCRSHLGGTCGYRAAGSSREDRHRSRRLATQFKALSAQTMADQNERATRSAQRTMSDAQRLLAPVSLALERLDRRLAEVEQERTDMTASLREQVAGVSTAGESLRKETASLVAALRKPQIRGAWGEMQLQRTAEVAGMLEHCDFQTQQTTTAQGAPQRPDMTVKLPGGRCIHVDAKTPLAAFLEAAQCDDAEEYDARWPVSHAMFAPTSTSSRPRLLAHRPRLPRVRRVLPAFRCLASGCTAGDTRPPRVRQPTRDRAGQPVSTHPDATHGRPSLAAGGRREICDRSRSTKTRPSQASRNPGRQPRQDGTIPDLDGASLQFGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW1</accession>
    <name>W4TFW1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67323">
        <property type="protein sequence ID" value="GAE67323"/>
        <property type="gene ID" value="JCM18909_370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848735" evidence="2">
        <location>
            <begin position="31"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="230" mass="25154" checksum="1778C7CB082A1237" modified="2014-03-19" version="1">MTDRREMTCRRWRAGFLVLASLASLTWAFAGMLNPAMSQLHAFVSEYSARDQPWRYLFQTTDVVMGTSLCLAGLATLAWARHRPLGRQGWSGIGFVVGGLFSVLDALVTMDCSPTRSPACMAAEEAGHVSASHIVHVGTSTVVVIGFALPILLLNSTMTRFRGFGLVVAWAWVIFTLLNGIGAMDWFNGTPMSYTGIWQRLSLGLGTLWWLTLAADDVITARARNHVPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX9</accession>
    <name>W4TFX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67691">
        <property type="protein sequence ID" value="GAE67691"/>
        <property type="gene ID" value="JCM18909_769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16546" checksum="BC5FC55B459187B2" modified="2014-03-19" version="1">MKAGNAPAHTTTTTNPATGKIKHVWLIILENKSYDENFTGLNQSSYLWKELPRQGALLNHYYGTGHYSQDNYITLVSGQAPQMDLQEDCGDVNSNFGSNSSIIRTHTGKQFGRNDNYGQAMSLAGPNAPAGKNGCTYPRIFPPCSTSSMPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG22</accession>
    <name>W4TG22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67089">
        <property type="protein sequence ID" value="GAE67089"/>
        <property type="gene ID" value="JCM18909_124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16365" checksum="81F063F37A56703E" modified="2014-03-19" version="1">MMTANLSVRGNVIDDTGGPLAAGPSLGYLSGPLTGADGSRRQRGDPMSAQTYEWYIETTSSRRGDLVVGPWQDELAEPVVVIDRRELMAGRPSAIARRKSLHDRFWDAAVLATIAVMIVGVILALGRLGQMWQGDLASGHEDHMGVVQVDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC8</accession>
    <name>W4TGC8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67587">
        <property type="protein sequence ID" value="GAE67587"/>
        <property type="gene ID" value="JCM18909_659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13374" checksum="99577D494B4F46D1" modified="2014-03-19" version="1">MTAPRHGEASDDSDAPEDTDRIASALSQRCSSLARRILGGAGMATMVAHTMISAGESQRSGPAISKPTALRRRGVSSSPSAPIPPRPSAKSRPDCPLMSGWRSPKTPQNRPSASWQPPSMCSEQLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI4</accession>
    <name>W4TGI4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67891">
        <property type="protein sequence ID" value="GAE67891"/>
        <property type="gene ID" value="JCM18909_983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12616" checksum="450EDADED03C2871" modified="2014-03-19" version="1">MGMDSGGWTGYLLTPLAGCVLTVTMGRGHAIDRYLFTVLSLGWMWWLSRGAEFIGGFDVIGVMAVAVVLVIVWSAPVNTWIKAVAERDKVIANPPEEGWLAPGQVQPWQATSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM7</accession>
    <name>W4TGM7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68120">
        <property type="protein sequence ID" value="GAE68120"/>
        <property type="gene ID" value="JCM18909_1237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12906" checksum="156B24FEE060DF8E" modified="2014-03-19" version="1">MTTTMTSLASTPGLEAITWWCSHDVSRDLLDFPELEYSLGLFTNDGKPKPEAQALSDMLPDLHNAQPQNQLDEPLEFSANWDTGQGRSTCSPIGDLFAQWVDQAEQTGKAPRLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGQ8</accession>
    <name>W4TGQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67608">
        <property type="protein sequence ID" value="GAE67608"/>
        <property type="gene ID" value="JCM18909_681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5206" checksum="06C3872D7DDEB744" modified="2014-03-19" version="1">MCGTLMAAGLPADDAALCAAGMQAATAISMPGPYAPDQIAELLPGTVTTVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT7</accession>
    <name>W4TGT7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67747">
        <property type="protein sequence ID" value="GAE67747"/>
        <property type="gene ID" value="JCM18909_828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="3885" checksum="C0C59BB85A19F307" modified="2014-03-19" version="1">MNDFSCKVKPGDRPVILIPGTGGNAFATWSFYGPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX3</accession>
    <name>W4TGX3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68215">
        <property type="protein sequence ID" value="GAE68215"/>
        <property type="gene ID" value="JCM18909_1337"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS_C" evidence="10">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11455" checksum="C5F4901F66CEA8B2" modified="2014-03-19" version="1">MGGETAEHPGLLAADEYDVAGATTGAVEYDDILGPQRVQEGDALLAVASSGLHSNGYSLVRKVLLADAGWTLDRHVDELGRTLGEELLEPTTVYAADLLASSVRSRCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX7</accession>
    <name>W4TGX7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-specific component BL0695 of predicted ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67787">
        <property type="protein sequence ID" value="GAE67787"/>
        <property type="gene ID" value="JCM18909_870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="23156" checksum="4AD9AC8086DAFC15" modified="2014-03-19" version="1">MWGLSGQYRHLEREIMKSRLTTRDLVTVAIFAVIFFVAFYACGMIGFAGPAFMFVGWILGILLGGIIVMLSMARVPKMGALTITGLLVGLGMTPGHTIWMIPAGLVLGFVADLVTTNAGRNVRLDPRRASLGYAIFTLWVVVPLIPMVVNADEYYTMITRQMGADYSNKMRALFTPGLVAGWAVVVFLLGLLGGWLGIKVGRKHFQRAGLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY1</accession>
    <name>W4TGY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68026">
        <property type="protein sequence ID" value="GAE68026"/>
        <property type="gene ID" value="JCM18909_1132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9663" checksum="0A62BED6CF16061B" modified="2014-03-19" version="1">MTPLRGLTDPVGPESPQTYWVRRLVLLIAAVVVVALVIAGIAKLVGGRKSRLLRWFRRSLRTRRGRTLRGRRRLLQQVHRSEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY8</accession>
    <name>W4TGY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1353</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68230">
        <property type="protein sequence ID" value="GAE68230"/>
        <property type="gene ID" value="JCM18909_1353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10461" checksum="83A90FD0D27EAB6F" modified="2014-03-19" version="1">MDTIWAMILPSLINPFGIYLCRVYSATVPTEVLEAARLDGTSEAGIFFKIVLRIISPALATVFLIQFVSTWANFLLPTMMLTTPEKQPLAVGLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ3</accession>
    <name>W4TGZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68041">
        <property type="protein sequence ID" value="GAE68041"/>
        <property type="gene ID" value="JCM18909_1148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="22157" checksum="252EE8E1CC7603F4" modified="2014-03-19" version="1">MKLGVFGATGQVGRVMRTLLAERHFPADEVRFFASARSAGQKLSWNNGSGDSEVVVEDTATADFAGLDIAIFSAGGGTSREFAPRVAAAGAVVIDNSSAWRRDPDVPLVVSEVNPEDVAKRPKGIIANPNCTTMAAMPVLKPLHDAAGLTRLVVATYQAVSGSGAAGVRALTDQTTAIDDPAGLALDGRDVPVADLGLRRTDRVQRSSGGGKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH19</accession>
    <name>W4TH19_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68076">
        <property type="protein sequence ID" value="GAE68076"/>
        <property type="gene ID" value="JCM18909_1188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10371" checksum="5298DC4898047372" modified="2014-03-19" version="1">MTDKDFAWPGGYDSLTCGVNNTALVYRDLEMARRRIVWWHVYSGEAFELFISPSHWGYRVAYVRLDGFGERSVPVIDDGDCDSDMVIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH43</accession>
    <name>W4TH43_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68290">
        <property type="protein sequence ID" value="GAE68290"/>
        <property type="gene ID" value="JCM18909_1414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="108"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="280" mass="29667" checksum="D110F07E9E3590BA" modified="2014-03-19" version="1">MTVATLVVAIASTLTTIARGTRIVAGQGTLALDGPTLATWVILLATGLGTVVLFAERVGTTQTAFVASASSVPGSPLEAKAEQEHREHTEVYPLLMFAALGMMCFAAANDLIMMFVALEIFSLPLYLLCGMSRRRRLLSQEAALKYFLLGALSSALFLYGIVLLYGCAGSFKLGDLAAAGVTQVGSSKLIVAGMILVAVGLLFKIGAVPFASWTPDVYTGAPTPVSGWMAVATKLVALVGLMRVLYVGLGAMRWDWQIVLAVVAVARWVWAPSWVSRRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB7</accession>
    <name>W4THB7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68355">
        <property type="protein sequence ID" value="GAE68355"/>
        <property type="gene ID" value="JCM18909_1484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17269" checksum="3C70FBCC4D72FC2F" modified="2014-03-19" version="1">MEELQAIAAEHEIEIDQSWEAGKVVMELFGELVEPGLINPTFVCDYPAIAQPLARPHRDDPRMVEAWDLIIGGMERGTGFSELVDPVIQREVLTKQSLAAAAGDPEAMQLDEDFLEALEFGCPPMGGLGLGVDRLVMLFTNAGIRETILFPLLKPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC4</accession>
    <name>W4THC4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane alanine aminopeptidase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68191">
        <property type="protein sequence ID" value="GAE68191"/>
        <property type="gene ID" value="JCM18909_1313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERAP1_C" evidence="2">
        <location>
            <begin position="138"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="402" mass="44200" checksum="4A3C8BE91920DE1A" modified="2014-03-19" version="1">MLKQLVAHVGVEWFFSAARHYFRELAFSSATLDDLIRHLEKACGRDLSAWVDAWLKTAGPDVLLPELTISDGIVSELAVVRDSIDVRTGRDVNRPHTLRVGLYSLHGEDLVRTNLIDLTISSPRTPVPEAAGKPAPDLILINDDDLTYAKVRLGATGTKTVLAHLSGLADPLARALVWSMLWNAVRDAKLKVQDYLDAVAAHGPKETEPAILATVLQQLRMAVENYLPDPARETARYAEAARAWQGLDESEPGSDLQRLWARHALALSATDPDSVGRVRGLLDGNVAGLVVDPEMRWQSWMALAALGQASVEDLDAELERDHTKTGVAHHMAALTARPDDAAKQEAYRRLRTPGELSNEHCLASSRVCVPRWVPRRLPISMAPTSMILSRSGRSSRSRWPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE2</accession>
    <name>W4THE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67574">
        <property type="protein sequence ID" value="GAE67574"/>
        <property type="gene ID" value="JCM18909_645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="8708" checksum="D232024C3230EDEF" modified="2014-03-19" version="1">MTGLLAGRTALVTGGTAGIGRGIAEVLALHGARVAVTGVTEERCAQAREDGLDVYQLDVRDKKACVRVVNDVAVECGGWRTDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI4</accession>
    <name>W4THI4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67962">
        <property type="protein sequence ID" value="GAE67962"/>
        <property type="gene ID" value="JCM18909_1064"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20227" checksum="CDF4E079F3FAFB62" modified="2014-03-19" version="1">MKTVFSLGSNMGDPFAHLRDAVRLIAETPGIHDVVVSPVYVTAPIGGVEQDDFLNLVVVATSDLPPSVLLERAHVIEEVHGRDHTIPNGPRTLDVDLIRVGDETVTTDELTLPHPRAHERAFVLVPWRDADPEAELPGYGRIADLVASFDADELADAVKPYSRQIDVAGVTVAGEWDERHDEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ4</accession>
    <name>W4THJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein 60 family chaperone GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67639">
        <property type="protein sequence ID" value="GAE67639"/>
        <property type="gene ID" value="JCM18909_712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="22519" checksum="5E9DB2881CAD8D87" modified="2014-03-19" version="1">MAAKQLQFDEEARRSLERGVDTLADTVKVTLGPKGRYVVLDKKWGAPTITNDGVTVAKEVDLTDPYENLGAQLAKEVATKTNDVAGDGTTTATVLAQALVHEGLRAVASGANPVGLKRGIEKAVDAVVEELRSISRAIDTTSDMASVATISSRDETIGALIAEPSTRLVRTGLSPSTSRRPSALSLTSPRACSSTRVTCRLTWSPTRTAWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV0</accession>
    <name>W4THV0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mobile element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67749">
        <property type="protein sequence ID" value="GAE67749"/>
        <property type="gene ID" value="JCM18909_830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="12080" checksum="1A5F242A69878482" modified="2014-03-19" version="1">MERVLSDNGGVYRSHLWRNTCNELGIKHKRTRPYRPQTNSKIERFHRTLADGWAYARCYTSEAERRGKLGDWLHYYNHHRPHPACGNQPPFSRLTNIPGQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX0</accession>
    <name>W4THX0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coaD</name>
        <name evidence="8" type="ORF">JCM18909_1234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68117">
        <property type="protein sequence ID" value="GAE68117"/>
        <property type="gene ID" value="JCM18909_1234"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="121"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="22791" checksum="D3E635ECA501F695" modified="2014-03-19" version="1">MKVVFSGSFDPITLGHVDIVTRAAELVDEVVVGVAMNSAKNGIFSMDERVAFVKDAVADIPGVEVALVDGLLVDFCTEMGADAIIRGLRFGGDFDYELQMAHLNKAMSGIETILLPAGREFGTISSSMIRSAACNGGNVSEFVPEMVNAALHEKNSRINDFFRYWRTLLTPFRFGGYGRVITVPVALPSTDFRKALATSADFTAGKPGKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX2</accession>
    <name>W4THX2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate dehydrogenase E1 component beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_852</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67769">
        <property type="protein sequence ID" value="GAE67769"/>
        <property type="gene ID" value="JCM18909_852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="2">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="249" mass="27376" checksum="E0C4549EDA6053A3" modified="2014-03-19" version="1">MGEDVGTLGGVFRITDGLKAQFGGRRVIDTPLAESGIVGTAIGMAMRGYRPCVEIQFDGFSAPAFDQIVSQLARYRARVGGRWSLPVTIRIPFGGGVGSPEHHSESPEGFYANTPGLKVVTCSNPDDAYWMLRQSIDSPDPVIFFEPKRRYYTRGHVAQTPTLGLHQTRIARSGEEATLICYGPMVDTCVEAAKERLRRGENSRLLTCVASPRSTWRLSTNRCVVRQGPSSSRRHHAPRRRRGDRGSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY2</accession>
    <name>W4THY2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68386">
        <property type="protein sequence ID" value="GAE68386"/>
        <property type="gene ID" value="JCM18909_1521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6042" checksum="9A4B7B794C3894F6" modified="2014-03-19" version="1">MSDGKFNQAQEEQAKKLRRLKPRKKGFLAEASGDRCCCGRHLCGDRRYRGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI16</accession>
    <name>W4TI16_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67809">
        <property type="protein sequence ID" value="GAE67809"/>
        <property type="gene ID" value="JCM18909_894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8212" checksum="4AC4A5BE8DF5A6F6" modified="2014-03-19" version="1">MDVLSAISARVIPGVFSKNLDDSLPRSAAQLIVSVPIHARRAKVGELNICHQLPQSVIVPARRLGPQYARVRRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI25</accession>
    <name>W4TI25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68182">
        <property type="protein sequence ID" value="GAE68182"/>
        <property type="gene ID" value="JCM18909_1302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849094" evidence="1">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="18242" checksum="61F811D7AD56CA53" modified="2014-03-19" version="1">MAGLMVAAVVTGTVGVPVPALAAGGPKPADYAAQAGKAVDYIDSHSADLTKGDLGPELDGALALISAGKTNAATFTTIKNDIKDKGPTYCTSKNVGGCAKATITLLAAGESPTYGGVDYAGPVTSFPDSVLNEHPFHQALDMIALERLGQPIPQKLFKSHQLCLDASQTELSEYCEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI49</accession>
    <name>W4TI49_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68108">
        <property type="protein sequence ID" value="GAE68108"/>
        <property type="gene ID" value="JCM18909_1223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="31"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="319" mass="35162" checksum="EEE61FDFF2A590AB" modified="2014-03-19" version="1">MAETGLMTPPDLQPDVLRIIPLGGLGDVGRNMSCYEINGEMLVIDCGVLFPEDDHPGVDLLLPGLDYLDEEKLARVKALVLTHGHEDHIGAVPYLLKRRPDIPIYGSKLTLALVEAKLREHRIKGYKLNVVHEGDVAEVGEQFDLEFIAVNHSIPDALAVCVRTDAGTLINTGDFKMDQLPLDGRITDLRAFARLGEEGIDLFMVDSTNAEVPGFVKSETEIEPAIERVFEKAKKRSLLWLASPPMCIASSKCSIWPCVITARSATSVVQWSAIWLLLRTWATSTFRRTLSSSCANSTTTEITRSSSSPLGPRESHFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI75</accession>
    <name>W4TI75_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carotenoid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68660">
        <property type="protein sequence ID" value="GAE68660"/>
        <property type="gene ID" value="JCM18909_1811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="195" mass="21472" checksum="21AB6B5A74DF251C" modified="2014-03-19" version="1">MGTVHIVGDELVALAAALRLAQVRHKVTIISSSPRWLESAERPLAPELGATLQVPSAWRDLFAKSGWAMEAELVGIGLNLVTEPDTQISSSVADISLPTDRGAQIHTVRDRYGHRTAHKWRDVLDHADTIWQARRQYGVEHAVTSRPEPLPEPLHVDLPSPLAELSADETRLAITRIFGCWNLVGLMAQLICNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ4</accession>
    <name>W4TIJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septation inhibitor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68357">
        <property type="protein sequence ID" value="GAE68357"/>
        <property type="gene ID" value="JCM18909_1486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7130" checksum="C8C3F2992688BF86" modified="2014-03-19" version="1">MPESKVRPQAKKKAQAKDRATMDERRAEKKKAAPVDRSWVPKVFVPLFFTRGVVADRLLHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ5</accession>
    <name>W4TIQ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen III decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68019">
        <property type="protein sequence ID" value="GAE68019"/>
        <property type="gene ID" value="JCM18909_1125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14324" checksum="06B007ADF30E8A93" modified="2014-03-19" version="1">MPLALAGAEVRIEPGVGPVLDEPVRTASDVDRITRRHVEDPSVIEEAARLAITELGDATPLIGFAGAPFTIAAYLVEGGPSRDHLSARAMMHSDPQTWARLMEWVADLDAAFLLLSCAAGRVPSSSLIPGLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR4</accession>
    <name>W4TIR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68034">
        <property type="protein sequence ID" value="GAE68034"/>
        <property type="gene ID" value="JCM18909_1140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="4">
        <location>
            <begin position="68"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="277" mass="31379" checksum="AD0E977BC47E295D" modified="2014-03-19" version="1">MSRKPEPMTNPISNRGTAFTRAERLEHGMIGRLPAVVETLEQQAQRCYRQLQGLGCNIDRYVFLEELQNRNETLYYKLLVDHLVELLPVIYDPTVGEAIKKWSHAYRRSRAVYLSVDHIEDVRPSFETLELGPDDVDLLVVSDSEQILGIGDWGVNGTDISIGKLAVYTAAAGIRPERTIAVNLDVGTDNAYLLNDPSYLGNRHARVRGERYDELIHEYLEVVSELYPHALLHFEDFGASNARRILVQNAANHRIFLMTTCKARQPSCWQPSSLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS1</accession>
    <name>W4TIS1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68860">
        <property type="protein sequence ID" value="GAE68860"/>
        <property type="gene ID" value="JCM18909_2027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6753" checksum="AFDF3B1C46631E94" modified="2014-03-19" version="1">MLAVSPKSGLMPEWPGEVGENPTLTRNRDHACVVWESEYQERRGGMRFRRGSRGQHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIT2</accession>
    <name>W4TIT2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68422">
        <property type="protein sequence ID" value="GAE68422"/>
        <property type="gene ID" value="JCM18909_1558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8509" checksum="265719418D0A9FD8" modified="2014-03-19" version="1">MISPLTIGIAMYIWMHQVCGRIGREQNRRGMKSGVTAGDFWLWAVLGGFIIVGPFIFMHKFLHAVNALAADYNVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIW5</accession>
    <name>W4TIW5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Na+/H+ antiporter NhaA type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68895">
        <property type="protein sequence ID" value="GAE68895"/>
        <property type="gene ID" value="JCM18909_2067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="4570" checksum="95A60CF3860E56FE" modified="2014-03-19" version="1">MLMASFLAAILGGGMLHHRGKSHAMRQTKHSHEVPVAAGTCND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX5</accession>
    <name>W4TIX5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68373">
        <property type="protein sequence ID" value="GAE68373"/>
        <property type="gene ID" value="JCM18909_1503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="24649" checksum="27FFA82B83C6B1F2" modified="2014-03-19" version="1">MVTSDIEGPHPDLPWSDEDIDTTLASLSRLAEVTADFHQQWEPFSARLQNTPSVWEQFMADTPADLDPWLIERLPDLAGRVERLARHAYGDTVIHNAVRSDNVLLRTSGTVLVDWSHAVIGPAWVDAAGLIVDIIHTDPIDAPRWNRADDLVKRVAAEFSPSAHGEPAVEPIVDFLVAVLGLSERECRNPDPAGMPQFREFQRERASRLRAWLWASEHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY1</accession>
    <name>W4TIY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68746">
        <property type="protein sequence ID" value="GAE68746"/>
        <property type="gene ID" value="JCM18909_1902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="8877" checksum="532AD397B3F81B47" modified="2014-03-19" version="1">MANCPYLSNAVVLGEGHKYAVALLTLDRDALMTWGKRHGKADASYAELTADHACGAVFSGTSIGLIRGLNAGRPSRNLPFLTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ78</accession>
    <name>W4TJ78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68214">
        <property type="protein sequence ID" value="GAE68214"/>
        <property type="gene ID" value="JCM18909_1336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9302" checksum="A27698A37B29E10F" modified="2014-03-19" version="1">MLATSTDGVGTKAAIAQAMDVHDTIGFDLVGMLVDDLVVVGAKRGSSPTTLRAATLTPTGLPLSSRASPQRVLKPAVPCWAARQLSIRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG0</accession>
    <name>W4TJG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68289">
        <property type="protein sequence ID" value="GAE68289"/>
        <property type="gene ID" value="JCM18909_1413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6107" checksum="93680F9BCE8E7684" modified="2014-03-19" version="1">MNPALLITASGLPALLDVAAPHLEWGPLAPVFVLMAGACVAVLVEAFVPRSVVVRLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ5</accession>
    <name>W4TJJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunits gamma and tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68936">
        <property type="protein sequence ID" value="GAE68936"/>
        <property type="gene ID" value="JCM18909_2111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="242" mass="26194" checksum="AD205BCDEACC2798" modified="2014-03-19" version="1">MRDLVIVSAVPDACRSGLIDVSPEQATRLTHQVAGFGAGELTRAAEVLATGLTNMRGTTAPRLHLELMCSRILLPGADTDGRGIHARLERLERRIGVSGPVEEVERAERPVTAQPPTRYAETPQQASPPQHWPAENLQNPERRSAPEHHDAPSPGQRPSGVHVPAVRITGPAISLLNSRRPTSTAMMVRCRRDQGSRAVRQPVSASNPDLRTTSRLSGIVRTPHRPNLNSLPPNKAVAPTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK9</accession>
    <name>W4TJK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68727">
        <property type="protein sequence ID" value="GAE68727"/>
        <property type="gene ID" value="JCM18909_1881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5523" checksum="9EE783A140D7176A" modified="2014-03-19" version="1">MPMAILKKLWFVALGIVASVVVFFGHPHSARGQDDPISTRGLCQGRMAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP4</accession>
    <name>W4TJP4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JCM18909_2366</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69175">
        <property type="protein sequence ID" value="GAE69175"/>
        <property type="gene ID" value="JCM18909_2366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="348"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="180"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="42"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GAE69175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="467" mass="49591" checksum="5203AA41253A00B0" modified="2014-03-19" version="1">MSSHFDVVVLGAGPGGYVAAIRAAQLGKKTAIIEKEYWGGVCLNVGCIPTKSLLRNAELAHIVTKEAKTFGIGGDITVDFGKAFSRSREVSARMVKGIHFLMKKNKITEFNGWGEFTGTKAISVKDSDGKVTDEITFDNAIIAAGSVVKTLPGAQLSGRVVTYKEQILSDTVPGSIVIAGSGAIGTEFAYVLANYGCDVTIVEFLDRMVPNEDKEVSAELAKAYKKLGIKVLTSTKVDSIDDSGDKVKVTVSPSKGGESKVIEADRVLQAVGFAPRVEGYGLEKTGVKLTERGAIEVDDFMRTNVDGIYAIGDCTAKLMLAHTAEAQGVVAAETIAGAQTMPINYDMIPRATYCQPQVGSFGYSEDQAREKGYDVKVSKFPFAANGKAWGLGDGTGFVKIVADACHGELLGASLVGHDVSELLPELTLAQLWDITAEEIGRNIHAHPSLSEALKDAAEGVEGHMINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX4</accession>
    <name>W4TJX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68837">
        <property type="protein sequence ID" value="GAE68837"/>
        <property type="gene ID" value="JCM18909_2002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8024" checksum="1E9BE23665F6DB62" modified="2014-03-19" version="1">MRIEGTRNRWVWYLEHVEIIGIETALGHYVEALSRLRAAPAHSTTEGDPFAFLGEPVFWTSGGRRGASIDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX8</accession>
    <name>W4TJX8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69265">
        <property type="protein sequence ID" value="GAE69265"/>
        <property type="gene ID" value="JCM18909_2462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="15972" checksum="2E2C01E35B7D2DAC" modified="2014-03-19" version="1">MATIADLLDERSIDLSLSSGDKDDVIERMVDLVDASGALLDRDVLIKAVRAREEAGTTGLGDGIAIPHGKCDGVDRPALAFARSDEGVSWGAPDGSLANLVFLIAVPEAAAGNEHLRILASLARSLVKADFRNQLLAASTPQEVREVLAGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK03</accession>
    <name>W4TK03_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thrombospondin repeat and PKD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68862">
        <property type="protein sequence ID" value="GAE68862"/>
        <property type="gene ID" value="JCM18909_2030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="166" mass="17805" checksum="CEA66FCFCBBEE9AA" modified="2014-03-19" version="1">MDMIALERLGKPIPKALFVKVTDDATKGSQWEDPDTDGLTLTALSHVKATPEQQGKITNAKAALVKRLDGSKQGEAWGFKGKGPNVNTTAWVAPGLFRAGDADHQQQAVKGQEWLVRQQKSDGSFRGLVTTPAGIMMATTQAVPALRGLQSYDNVGAHQAQEEPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK27</accession>
    <name>W4TK27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-amino-4-ketopentanoate thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68474">
        <property type="protein sequence ID" value="GAE68474"/>
        <property type="gene ID" value="JCM18909_1615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14108" checksum="02DDBF992C03B0DD" modified="2014-03-19" version="1">MSSTGYSLDDVARIQAETKVGDTPLYELHRLTEAVREIAGPGKGARILLKDEAANASGSFKARRASLSAHEAQVKGFAGMVTATSGNYGAGVASQAAQRGLACIVIQEIYDSQHVGQPEIVEKNPEPARPTAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK43</accession>
    <name>W4TK43_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68803">
        <property type="protein sequence ID" value="GAE68803"/>
        <property type="gene ID" value="JCM18909_1966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4981" evidence="1">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11607" checksum="876A1967A084002F" modified="2014-03-19" version="1">MINRRDFSDLSDLTFVWQLVNDDEYVQTGVLEVGALAAHQIWTGTVPLPDEISDRMVVVVEAKLVKDTIWAPAGHVVARTSALLVPKPGPRLYLPASSQSHRDGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK58</accession>
    <name>W4TK58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68519">
        <property type="protein sequence ID" value="GAE68519"/>
        <property type="gene ID" value="JCM18909_1663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6224" checksum="564087CB3FDBCBA0" modified="2014-03-19" version="1">MTANSQRDTETAARDAKQPATKLDDISDSTPATPAQQDQEAASGDDSARSSPTDTGDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG0</accession>
    <name>W4TKG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69012">
        <property type="protein sequence ID" value="GAE69012"/>
        <property type="gene ID" value="JCM18909_2192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="17721" checksum="14607272180E4756" modified="2014-03-19" version="1">MSATIPDHITHHGDNTPGQLDLSRPSGKRTTKSGCASAFMIVATVLAVIPLAWLLFSAIQRGIGSLFHASWWTHSMDPSFDLAEQGAIHAIVGTLEIGLITSIISVPIALMTAIFLVEYARGTKIAKVISFAVDVLTGVPSIVAALFVFAVVVTTFGGTQSAWASSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI5</accession>
    <name>W4TKI5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69311">
        <property type="protein sequence ID" value="GAE69311"/>
        <property type="gene ID" value="JCM18909_2512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="330" mass="35629" checksum="8DD461B4517EB024" modified="2014-03-19" version="1">MPICHTKLGLVRKARWNLEEAGAAGYRVGVRIVSTMNPILGADMTTYQYLIVGGGMAADSAARGIRDIDKKGSIAILSADVDAPYPRPALSKKLWTDPEFTWDQADLATVADTGAELRLGTEVLSIDRDGKTVLTASGQVFGYQKLLLVTGLVRRALTMTAMPSSTFGLLGTARSCVRWPSPVTSSWSSVADILVPSLLRASSSRAARSPSSPPIRRWVVRNSRPRLRLSTRSFSPMLGCTSSLGSASVRCANMKWPRSPSMTALSSRLTMLLRVWGHPRSPNWPRKQALPLMMGSSLMSSCAPTIRPSGPPETSPITRTRCWAAPASSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU4</accession>
    <name>W4TKU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68779">
        <property type="protein sequence ID" value="GAE68779"/>
        <property type="gene ID" value="JCM18909_1936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1998" evidence="1">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="279" mass="30349" checksum="512D1CC522D74251" modified="2014-03-19" version="1">MRTVALTRSLTTQAVVLPLPASIVTGDMFALPSLRAALLLGLREQFGGTPDHLGIMPIKEPVDDRTRDALLLHDLVPGGTGYLAEFTSPQNVWEALRRAFQIVHDCPCKDEERLACHRCLLPLASAREARYVSRAKAEDCLKVLMGLADGDTPSTQMTWEIATTPPTISSDDESYLESRFRESFMALARRLNATVSQNYGPAATSSTCASGKCCTPCNLKYSCPAANPISSCAVAIVQIWRFSPTGRPSTRPRNATGCATTPRNALSSATLESRCWRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX3</accession>
    <name>W4TKX3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69605">
        <property type="protein sequence ID" value="GAE69605"/>
        <property type="gene ID" value="JCM18909_2842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="13318" checksum="31A1CE94E7DD47EA" modified="2014-03-19" version="1">MTFLPAFLLKVLGPFSSANTTFGDADFGWFGILIGYGARTGTFSGSIILALIGATILGSAILVQRRAGGWDPAPARGSSSDGVTAVVTAEEVSDDPDEATRTATASTISHRRIAPPVGAPTPPSRDELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL62</accession>
    <name>W4TL62_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69710">
        <property type="protein sequence ID" value="GAE69710"/>
        <property type="gene ID" value="JCM18909_2959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="5">
        <location>
            <begin position="155"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="322" mass="34172" checksum="E6AD475900386380" modified="2014-03-19" version="1">MTVMSTFDATRRASKISVVGAGSVGSSLAYACLIRGSAGLVSLYDIAKDKVEAEVADLAHGTQFTPASVMGGADVHDTADSDVVFITAGARQKPGQTRLDLAGVNANILRSLMPQLVEQSPNALFVLVTNRVTSSPSLPRRPPDCPPTGFFSTGTMLDTSRLRWLIRQWANVEQRHVHATIVGEHGDSEFPLWSTANISGVPIRDWAVDGNRVFTEDVLADLAHEAAYAAYKIIEGKGATNYAIGLTGARLAEALLRPGRSVLPLSSVMTDMHGISGVALSMPCIVSRDGIEGVVPVAMDTEEIASLKASAERLRDTLSSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL68</accession>
    <name>W4TL68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69188">
        <property type="protein sequence ID" value="GAE69188"/>
        <property type="gene ID" value="JCM18909_2379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010743">
        <property type="entry name" value="Methionine_synth_MetW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07021">
        <property type="entry name" value="MetW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11456" checksum="2525E9F9FA4945B6" modified="2014-03-19" version="1">MPALELDVNEDLGEFHDDSYDVVILSQTLQAVVCPDVVRADMARIGTVLILLVLNVVYWRSRLKIIGEKIPVSHDLRIPGMTPLASPMQGSPTARSGSQALTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB2</accession>
    <name>W4TLB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major myo-inositol transporter IolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69770">
        <property type="protein sequence ID" value="GAE69770"/>
        <property type="gene ID" value="JCM18909_3021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="383" mass="41508" checksum="04534F29EABFDB4C" modified="2014-03-19" version="1">MALDQFMIVFGQLLAFSVNAAISAAHGGPSLMVTADPTGRLSPGTYSWDTLQAMTTSHGGAMTDEAFHTFLTQLSVSAGSGGAWRWMLVVCTLPAIALWIGMRKMPESARWHLSHGQLRETIACLKQVRVEGVDEPIVDEVTEMVELNGEGGRLSHRQQWAVVMESRWTRRLLLVGIFLAAVNQTTGVNTVMYYAPKVLEFAGMSTQASIISQVANGVMSVIGAAAGLWLIERFDRRHLLIFDVTAVGMCLLGIAATFGLAIAPHVGQGVPKWAPILVLVLMSIFMLIVQSTNGTVVWTMLGEMFPTRMRGAMNGAAVFCGWLANATITWTFPAMLAGLGGAGTYLTYGLVNLVIALVLIKVMPETKGRSLEEIEVEMRQRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC6</accession>
    <name>W4TLC6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69785">
        <property type="protein sequence ID" value="GAE69785"/>
        <property type="gene ID" value="JCM18909_3037"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="5">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15133" checksum="7A84DA6630AF18D2" modified="2014-03-19" version="1">MTSSPFTHLRGNGSAHMVDVTTKTPTVRVATAECCVVCSKPIMTALRDESVPKGDVLAVARIAGIQATKHTPDLIPLAHRIGVHGAEVDLWLEADRVRIRATTRTTDRTGVEMEALTAVTVAALTFADMVKGVDRASPSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC7</accession>
    <name>W4TLC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69546">
        <property type="protein sequence ID" value="GAE69546"/>
        <property type="gene ID" value="JCM18909_2773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9567" checksum="D48A4C9D002C0D5A" modified="2014-03-19" version="1">MKLYVDLDDKGYHIHGAGQDRRGTWDKVTKAALTESRSRLTLYHGQVGRTHIVRPGIGDPKEMDDLAVDVAHRLDESRGYRHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF5</accession>
    <name>W4TLF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68984">
        <property type="protein sequence ID" value="GAE68984"/>
        <property type="gene ID" value="JCM18909_2162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="197" mass="20269" checksum="B91C3E0BB84E5FB9" modified="2014-03-19" version="1">MGRLALADEALMDADSAKLNDDMHPERGDSTMIDRRRTTAVLAAVGVLGVAACGADPKVLTSYTPAAGVNGKSATVKVQNLVLINGGGQARVSAAVVSRKDDNIVGITGEPLTSNNSLSGRSFTMRTVNVKLPAQTSVNLTQSKLQAPVEGLSNGLLAKVTIKFANSAPITLDAPVVSSTHPDFAEYAPSGIPSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI7</accession>
    <name>W4TLI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69303">
        <property type="protein sequence ID" value="GAE69303"/>
        <property type="gene ID" value="JCM18909_2504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6798" checksum="65AC8AC3C2640953" modified="2014-03-19" version="1">MVELWDWTLAPGERHDSEAHSGGTRELLHVQEGTVTVEVDGNRYDLAPGDALSFYGDAPMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLQ1</accession>
    <name>W4TLQ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69427">
        <property type="protein sequence ID" value="GAE69427"/>
        <property type="gene ID" value="JCM18909_2639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10969" checksum="29CAAE1AACB79C4D" modified="2014-03-19" version="1">MWASVDGRPVGTLRILDDKDHLVIGRVAVDAAYRGLRIGRRMVNLALEIAHADDRDVALHAQSYLENWYRDCGFVVTGPHCEELGSIMSRWFCVAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU1</accession>
    <name>W4TLU1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69159">
        <property type="protein sequence ID" value="GAE69159"/>
        <property type="gene ID" value="JCM18909_2349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="23367" checksum="084F20B1D9A6E4F0" modified="2014-03-19" version="1">MRPPIIISSHRGRIGVGVIVAVIIVLTILDLIRSGLAGLSNLPTLLLFVWLVWIIWGVAEIRIDDEGVNIVNQFRIWDVPWRRITEVTGRWGLSLTAERRPDAEGMRKPRTISAWAAPARGTATAMKGNADHIPQIIIGSETPMRWSLDSHSTARLIEMERIERHPSGAVASAKGHEAADSGTKSYDGEIHVHPNWMTICVTVVLVATVIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV1</accession>
    <name>W4TLV1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-succinylbenzoic acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69492">
        <property type="protein sequence ID" value="GAE69492"/>
        <property type="gene ID" value="JCM18909_2712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding_C" evidence="1">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="226" mass="24116" checksum="46FCA8CB8772B0D6" modified="2014-03-19" version="1">MSRLLDDPVGTEALTRCAAVLVGGAAASASLLSRARKAGVPVRVTYGMSETCGGCVYDGVPLEGVRVDLADDSRVRIAGPMIMSGYLDEGPVGPWLATQDLGHWQGGRLGHRRAHRRRHQLGRLKIAAGQVLDQIRATGMVRDGLVLGLADATWGQVVTAVVVPGRGWRGPEALRDLVGRRLGRTHAPRVIVEVDELPILTSGKIDRVEVRRIATATLESGAAWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM69</accession>
    <name>W4TM69_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69498">
        <property type="protein sequence ID" value="GAE69498"/>
        <property type="gene ID" value="JCM18909_2719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16851" checksum="DA21B1399E25B057" modified="2014-03-19" version="1">MFLTQFDINVARRDAMRLLASPERLHAAVLGAFPPGQSVSDGARTLWRLDRGPARHDARLMIVSPLRPDLTALMNRPAGPMVPRSVRGLRPLSASAPIWVDVAFQMHDQSHDCRTQVCRVPGTTRRRGHSRTAANLVYRSRGTSRLHRASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM73</accession>
    <name>W4TM73_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69503">
        <property type="protein sequence ID" value="GAE69503"/>
        <property type="gene ID" value="JCM18909_2725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10421" checksum="B3CFCE754F55A7F2" modified="2014-03-19" version="1">MDIPVVERLVQIGGGGFKSDLLALGVPGECAFREVDHDILLSYLPGTMERVPMGLRVVRRRDAFAATVAHSAGASGSVPSWRVIRTVVASSSTMARTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME2</accession>
    <name>W4TME2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69359">
        <property type="protein sequence ID" value="GAE69359"/>
        <property type="gene ID" value="JCM18909_2567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8042" checksum="2946759A6A4E59B3" modified="2014-03-19" version="1">MHGVNVRLPRVGFGLGHSAVGEVGANPTLSRNGNACEAQSGRLPEEWQLLTLAVGVCRAHYVRPRETCGMTAGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME5</accession>
    <name>W4TME5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytosol aminopeptidase PepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70155">
        <property type="protein sequence ID" value="GAE70155"/>
        <property type="gene ID" value="JCM18909_3451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M17_N" evidence="8">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CYTOSOL_AP" evidence="7">
        <location>
            <begin position="168"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="25538" checksum="3C9BE3F908720017" modified="2014-03-19" version="1">MPTRRRRDCRSGRGSQGPTVQGLAPRAVKEAEETFGAPLVEVAIRAGGSTKIGSTVVLPWFGNSLVLVGCGAEGFDGESLRKAAGSGARAAADLSHGSSLKIAVDMGTVSAEQVRIAAEGALLGCYKVPTITATSNEPEISTVTIVSNARGAKPELNKARILTDAVYTARDWVNAPANLLYPKTFAASVQSWCNNLSDVTVDVLDEKALGRGGFGGILAVGGGSATPHVWSAWNTPRKDPPPRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW5</accession>
    <name>W4TMW5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69882">
        <property type="protein sequence ID" value="GAE69882"/>
        <property type="gene ID" value="JCM18909_3147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="244" mass="25887" checksum="23DE78006CE6C6F4" modified="2014-03-19" version="1">MLEICCRLTCLLNDLCANRTTAPHAEAELLRMAMAHHVHDPDEVLGLSEHDPLSSLPIRMALARISHNPHDTPVLWGLLLPVPGQLAGLRGPAQVNRAALDAGAIVICHQGSTTMPAGIAWIPHPVGSAMQWTVVRAAVPLPPPTPADTAPLLRSAISATAAQLTELSIVAGKRPDVVTPRLTGHRPADQRLLDSAWTVMMACDAGQEPTTITAYGAQTRETALRQLRNAASQAVTAATSWPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX2</accession>
    <name>W4TMX2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobD</name>
        <name evidence="11" type="ORF">JCM18909_3639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70325">
        <property type="protein sequence ID" value="GAE70325"/>
        <property type="gene ID" value="JCM18909_3639"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE70325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20497" checksum="CE661E5F267F132F" modified="2014-03-19" version="1">MAENASDAAVASLWWGAVAGLPGLFVHRGANTLDAMIGHHNDRYEHFGKVAAYLDDVVNWVPARLTGALAAVCAPTVGGDRKTTWRVVRAEHGHHPSPNGGWCESAWAAALGVQLGGRNVYYRNRVEFRPLLGSGPVPMLTRRPTRRAWSPRSPRQHLVCCRRAGQCAHVLFYGGLIPRGLLPHSKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN10</accession>
    <name>W4TN10_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60 kDa chaperonin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Secreted</location>
            <location evidence="6">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69589">
        <property type="protein sequence ID" value="GAE69589"/>
        <property type="gene ID" value="JCM18909_2823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="381" mass="39880" checksum="CFC75F5D2E846F70" modified="2014-03-19" version="1">MDKVGKEGVITVEESNTFGLELELTEGMRFDKGYISPYFVTDAERMEAVLEDPYILIVNSKISSLKDLLPVLEKVMQSGKPLFVIAEDVEGEALAGLIVNKIRGTFKSVAVKAPGFGDRRKAMLNDIAILTGGQVISEEVGLSLDAVTLDLLGRARQVVVTKDEATIVDGAGDSEQIAGRVSQIRKEIENSDSDYDREKLQERLAKLAGGVAVIKVGAATEVELKERKHRIEDAVRNAKAAVEEGIIPGGGVALLQASKAAEIEGLEGDELTGAQIVLAACTAPLKQIAINAGLEGGVVAEKVAGLPAGQGLNAANDEYVDMVEAGIIDPAKVTRSALQNAASIAALFLTTEAVIADKPEPVKAPAGGGDMDGMGGMGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN18</accession>
    <name>W4TN18_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase YncB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70370">
        <property type="protein sequence ID" value="GAE70370"/>
        <property type="gene ID" value="JCM18909_3686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PTHR43205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="338" mass="36184" checksum="8543D94449488EDC" modified="2014-03-19" version="1">MSITRPTTTRAVHLASRPHGAPTEDNFRIEEISLPELSDGQILVANDVMSVDPYMRGRMNDVKSYVPPFHIDQPLDGGAVGTVIESRSEEIPEGSHVVHQLGWREHAVLNAGDAHIIDTDIAPASAYLSVLGMTGLTAYAGLTRAAEMKAGDAVFVSGAAGAVGSMVGQLARLLGASRVIGSAGTDAKVARLRELGFDAAFNYHDGPSTELLGQAASEGIDVYYDNVGGDHLEAAIDHLNIDGRVAMCGAISQYNSVEPPGVPRNLALAIGKRLTLRGFVIAKYAEEVRPEFQQRMAEWLPADEIHWDETFRDGLDAAPQAFIDMLDGANTGKMLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN51</accession>
    <name>W4TN51_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70400">
        <property type="protein sequence ID" value="GAE70400"/>
        <property type="gene ID" value="JCM18909_3718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="8652" checksum="7DED9F5FA999269E" modified="2014-03-19" version="1">MVVETVQADTPAGDNAVASAMSSVIAWAEDAGYKRINFDGHRSDPHFGPLASRLPLEGASLNLMEISVLPADDAGDPADGGATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN87</accession>
    <name>W4TN87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69679">
        <property type="protein sequence ID" value="GAE69679"/>
        <property type="gene ID" value="JCM18909_2924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="12881" checksum="08283B5700CF01E3" modified="2014-03-19" version="1">MDLVVDQVVQLQHVHVADAHLRGEGLAGTAIEEGRLTVGVNEHVAIAGWVAVLQQTGDFLLGGTVEYRGGQTGFLRNINEANLAQTLSPIALGLGDIPAGVSNPARCISRTCPTFIREGTPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN92</accession>
    <name>W4TN92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70206">
        <property type="protein sequence ID" value="GAE70206"/>
        <property type="gene ID" value="JCM18909_3504"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="8">
        <location>
            <begin position="2"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="235" mass="24588" checksum="20779D1552E780F6" modified="2014-03-19" version="1">MGTDDSFGFSTALEIATEAIDRLHSTAHSHHRIILAEIMGHRAGWLALGSGIAGGADVILLPEVPYKLDSIVQAVENRQKQGLNFSVIAVAEGARDEADSAAMAGAQALVDASKTPETKAAAKKAKKDLEHSMRDNTLKLATQLEEATGLESRVSILGYVQRGGIPCAHDRLLATRLGTMGAKLVNDGEFGVMVAAQGGDATTVALKDVAGKVKYVPADHPWVKAARQVGTGLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN99</accession>
    <name>W4TN99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70420">
        <property type="protein sequence ID" value="GAE70420"/>
        <property type="gene ID" value="JCM18909_3738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="205" mass="21715" checksum="054D04A50D812FAF" modified="2014-03-19" version="1">MGAGLDRHLVRGAHRAPASPAVCDHHARRRDSSPGDHPVRLHSSYRIIGARDDEDPIPVLHALKPFGVSRVLLAHDSITSYLGALGDQLGVVTASGTGVITLAVGRHNVARVDGWGYIIGDAGSAFWLGRHGWMLSCAPTMVAASRQSLATPSATTLTTSRLPTWNSMPTRSWSHGSRPTQPQSPPQPKKGTTSPVISACAQPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH5</accession>
    <name>W4TNH5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69764">
        <property type="protein sequence ID" value="GAE69764"/>
        <property type="gene ID" value="JCM18909_3015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="3">
        <location>
            <begin position="13"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="304" mass="31556" checksum="FCE0A7240B294B31" modified="2014-03-19" version="1">MRAVHYHRSQGSTTLFASTVTAAIDDVVAQIGRLRQLVDLDEIAGIHLEGPFLAESRKGAHAVELLCDPDPVSVGRLIEAGGSALKMVTIAPERAHGLEAVTTFTTAGVHVAIGHTECDNTTASAAVDAGADVITHLFNAMPSIHHRKPGPVPPMLTDSRVVCELICDGVHLAPDVIRMAMSSAGPKRIALVTDAMSATGQPDGDYILGSLPVKVVDGRARLLAADGSLGAIAGSTLTMGRAVEFVTSVVGIPLGQVAVMAATTPAKLHGLNEVGVIEEGHWADLCLTDAKGHLVRVIHRGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI6</accession>
    <name>W4TNI6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69774">
        <property type="protein sequence ID" value="GAE69774"/>
        <property type="gene ID" value="JCM18909_3026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12206" checksum="FE83E6F0C23F8F35" modified="2014-03-19" version="1">MAAVLTGQRLTAPDNPGWQAVDVVEWLAEEGWPANRLANRRAEFQQAGRSWPGPIPDDLSPGLEFARYGAVLAQARRIAGLDGLTATVHRGAVVIGPDEARLLAERPPHSLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ2</accession>
    <name>W4TNJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70306">
        <property type="protein sequence ID" value="GAE70306"/>
        <property type="gene ID" value="JCM18909_3617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="388" mass="40990" checksum="57B98798F2CF5D66" modified="2014-03-19" version="1">MKVHSVSPDSSTVSKLVRYLLGASTIVGSLLLLKAASHTGLGALFGATLLWISGCVLLVAPILFFAICRVLSGLPGTSWAWPARISLVRNRVFKLSASVTVVALAAILFSSTVSMITGAEQAQREALAKSFRPTAIVATTPNGAPLDTATARHICTSTPDCSGIVLIAPENSSQSGEAYTTSQVIDTLYSKGPRKIVPGGLSASPWKHLNASHPSGLSEAWHGIPVFKTQSARLRSSLRHTSGIITQPATSWAHTGPTQAILRGSGAADIGPMMAPMLTMALLFAAASAYLLQASFHRTTHTIDMLGSDKFTDMIVVLADALARTLTVYAMTWASWILMARALMALGHSYGLHTIPHPLPNIVHAAFIGLFIITFFGGLLGMRAGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM9</accession>
    <name>W4TNM9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="2">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69814">
        <property type="protein sequence ID" value="GAE69814"/>
        <property type="gene ID" value="JCM18909_3069"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="308" mass="32597" checksum="F53FA6072C0F920B" modified="2014-03-19" version="1">MIGAMTMKSDLEIAREAHLDPIEKVAARAGINEEYLEPYGRGVAKVDLEVITHNRDHPRGKYVVVTAITPTSFGEGKTTTAVGLAQGLEKIGKHSVLALRQPSMGPTFGIKGGAAGAGYSQVLPMEKLNLHLTGDFHAIGAAHNLLAAMIDNHLHQATSSTSNLTRSRGVASSISMTVPYATPLLVLDRGSTASPARPDSISPRPARLASSWPWPPPCPICVLAWGVSSSATTAPRSQSAPRICTPPDRWPSFLKTPSSRTYYKLLRTARCSSTPALSAISPPVTPRSSQTASVSVAATTCSPSRIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN8</accession>
    <name>W4TNN8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70008">
        <property type="protein sequence ID" value="GAE70008"/>
        <property type="gene ID" value="JCM18909_3287"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="44"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="198" mass="21101" checksum="8E2B3694C139566D" modified="2014-03-19" version="1">MHVRSSFSDKPGTWVKEPADITKGSDMEEAIISGVAHDRSEAKITIAGLPDAVGRAAQIFEIIAHADINIDMIVQNASRVMNGRTDLSFTLPMSDGPTAVRALTAVKDELGYEQILYNDQIGKVSVVGVGMRTHPGVTSTFFRALADSGINLQMISTSEIRISVVVDADQVDEAVRVAHTAFGLDAEGEAVVYAGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP4</accession>
    <name>W4TNP4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69829">
        <property type="protein sequence ID" value="GAE69829"/>
        <property type="gene ID" value="JCM18909_3085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12219" checksum="6EC62F155F662E25" modified="2014-03-19" version="1">MVVMLWSTITRTTSRVSLGGRTTGGTRRARIGLKLAAGRLPTVSLPAGAHITVIETSPDKDTGTVSNLSTADAVVVAAPKATNDHGSWLVDVEVDSGNAARLADLASLDRIAVVERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW9</accession>
    <name>W4TNW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70103">
        <property type="protein sequence ID" value="GAE70103"/>
        <property type="gene ID" value="JCM18909_3393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10655" checksum="6E1D8D0D4A5FA1AA" modified="2014-03-19" version="1">MANPAHPTKDGATDVHELFLSNFFAQTAALPSVRPPTRCAPRALTRPLFPLGFFCRRPSDDVNHGSRTIPKVLGELIALYEHITFCAGCRLGYRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ6</accession>
    <name>W4TNZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000076">
        <property type="protein sequence ID" value="GAE70710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70710">
        <property type="protein sequence ID" value="GAE70710"/>
        <property type="gene ID" value="JCM18909_4093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5402" checksum="030DC79854BDCBE8" modified="2014-03-19" version="1">MIEAGKRFSFFRTASTACQAGLLVNSLFTICRASALFCTIEVTMMISGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP50</accession>
    <name>W4TP50_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ChlI component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70188">
        <property type="protein sequence ID" value="GAE70188"/>
        <property type="gene ID" value="JCM18909_3486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7683" checksum="93C6888B4D1C5047" modified="2014-03-19" version="1">MATKIGVDTRLSWVVIDTEDPRGIQLSRARDIATALSGPCLRIDDLRADDLVNVVSRLDPSHQSPRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPE2</accession>
    <name>W4TPE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70392">
        <property type="protein sequence ID" value="GAE70392"/>
        <property type="gene ID" value="JCM18909_3710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032344">
        <property type="entry name" value="DUF4862"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16154">
        <property type="entry name" value="DUF4862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="294" mass="31629" checksum="0207D64C3E867AC2" modified="2014-03-19" version="1">MNTAPTIVGAYAAMSRAIAERECLYRSLAETGWVDGIEIPYRDGLDADPRWLADQLRDRFAHCVVTAIPGTMGQLAGDPDFGLASSDEPGRQRALKWFTNLVDDVRALHEMVGHPVVRWVEVHSAPSRKADAKAFASSLVELSGLFEDAGLAVVVEHCDAAGGVGPGEKEFLSLDDEITAVVGTRVHLTINWGRSVVESHDPELLARQVARLADAGVLGGVMLSGAGPDATQYGPAWGDAHLPLRNDEPTSLLTTDLVSSFLDAARGLQPTKHQDPDSRRCHRRAAVGHDHLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPI7</accession>
    <name>W4TPI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70328">
        <property type="protein sequence ID" value="GAE70328"/>
        <property type="gene ID" value="JCM18909_3642"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="8">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17054" checksum="C57AE61864BD31F6" modified="2014-03-19" version="1">MHVDDEMRLTPTLPDGHGLRIGILTSGGDAQGMNAAVRAVVRSALSVGAEVYAIYEGYQGMIDGGDGIRRFGWDDVGSILNRGGTVIGTFRCKRMRERPGRLKAVRNLLEHGIDRLVVIGGDGSLTGLDVLRTEWTDLVAELVDTGQVSAEVAREHPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ04</accession>
    <name>W4TQ04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70463">
        <property type="protein sequence ID" value="GAE70463"/>
        <property type="gene ID" value="JCM18909_3790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16143" checksum="2FBBAA8276262CF1" modified="2014-03-19" version="1">MRSAVEAGATLRCGGEIPEGRGWFYPPTVLSDVPADAEIMQTEIFGPVAPITTFRTEKEALALANSVPVGLAGYVFTGDTARILRMGQKLETGMIGANLGVFSNAAAPFGGVKESGLGREVPTKVLKNFWRRSTSPFQRDSQAVLLRLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ87</accession>
    <name>W4TQ87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70389">
        <property type="protein sequence ID" value="GAE70389"/>
        <property type="gene ID" value="JCM18909_3707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="304"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="359" mass="39601" checksum="ACF67BE0DF57BB32" modified="2014-03-19" version="1">MRHCQTIRTDRLVLPADLADRKPVLEVKDLSIAFPQAHGDVDIVDKVSFCVRPGETMGLVGESGCGKSISSFAVMGLLPKTADIRGSIMFNGQELLTMTPKQRNALRGHEMSMIYQDALSALNPSMLIRSQMAQLTKRGGTRSAEDLLELVGLDPTRTLKSYPHELSGGQRQRVLIAMALTRDPQLLIADEPTTALDVTVQQQVVELLNHLREELGFAMVFVSHDLALVAQLAHRITVMYAGQVVETGSATEVMSDPRHEYTRGLLGSVLSIEAGQGRLHQVPGVVPSPSEFVAEDRFFHRVPRTRRSGVTSRPPCEPRPVPPTPGRTIRGREPGGISMRYQARPRRRYGRRYAGDRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQH3</accession>
    <name>W4TQH3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70479">
        <property type="protein sequence ID" value="GAE70479"/>
        <property type="gene ID" value="JCM18909_3806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="6"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="24203" checksum="D976C90ACD77756C" modified="2014-03-19" version="1">MLRWVFCRDALDAVMEIFPNSPIHIGGDECPGKEWFGHKPTRTRLAELGITTPHQAQAWFERQICGHVVAAGRQVIAWDEMLEAGAPEEVTVMVWRDADDIARAAAAGHDVIAAPARHTYLDHGMETGPQAPVTIDAPMTMDDVAGLHDVLAAVNSPHLLGGQFQLWTEYLCTPAQVEDAAFPRGTSIAEQLWTGNPARPLSELEAQTRRLTAMGVNWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDH2</accession>
    <name>W4TDH2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_24</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66995">
        <property type="protein sequence ID" value="GAE66995"/>
        <property type="gene ID" value="JCM18909_24"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE66995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5506" checksum="2C7C046B23C30D49" modified="2014-03-19" version="1">MELRHGFEGEPMTITAVAHELGLSASNVRRIEQRALGRLRRHLQQVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDS0</accession>
    <name>W4TDS0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma factor SigB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67105">
        <property type="protein sequence ID" value="GAE67105"/>
        <property type="gene ID" value="JCM18909_142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="2">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17374" checksum="40809AEEC66F01B1" modified="2014-03-19" version="1">MHVAEQVNQVSAARRNLERQLGREPETFEIADELEITEERVIELIRFGRDHVSLDAPVEDDGDTSLGDLIARETSPGPDDIVLDAEDRSRLEGLLDDLDERSADVVRRRYGLVDGRQAKLADIGKVWGITAERVRQIERAALASMRQRNLATMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDS4</accession>
    <name>W4TDS4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67110">
        <property type="protein sequence ID" value="GAE67110"/>
        <property type="gene ID" value="JCM18909_149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="4376" checksum="A47DD4AAC58CFCCA" modified="2014-03-19" version="1">MSAPFQLTSSDPSVIDPVGLAADTHEWIERWCQEECTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDV4</accession>
    <name>W4TDV4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67140">
        <property type="protein sequence ID" value="GAE67140"/>
        <property type="gene ID" value="JCM18909_180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="23850" checksum="F04C9592935D6401" modified="2014-03-19" version="1">MRIVIVGAGNVGRSIARELTAHGHQILLIDKNPKAMKPDTVPEAEWLCADACELATLEEARIDNCDIAISATGDDKVNLVHSLLAKTEFGVPRTVARVNHPGNEWMFDQVWGVDVAVSTPRLMAALVEEAVTVGELVRLFTFQKGRANLVELTLPDNSPRVGDRIRDISMPGDAVLVAIIRDGQGRAPEREAALEAGDELLFMISPNYEPDLVDLLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE13</accession>
    <name>W4TE13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_41</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67011">
        <property type="protein sequence ID" value="GAE67011"/>
        <property type="gene ID" value="JCM18909_41"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14114" checksum="F8CFB5A68EF90FC6" modified="2014-03-19" version="1">MSVDAATGKVLHDLYMTPQTVAGIVCDVRQALPHALFCTEEATQWFSEEGFDRWQISGPPDGESQIESFLGDDHRIVKLLVRTFGFPSDELFQIVKPIVGDRGTVTFSATMTDGLVEIAGRGSLRVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE28</accession>
    <name>W4TE28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain protein EC-YbbN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67215">
        <property type="protein sequence ID" value="GAE67215"/>
        <property type="gene ID" value="JCM18909_260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="44"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17436" checksum="D290D54426C479FF" modified="2014-03-19" version="1">MSSDSIHRHDAVDLSGLAAAASSADSPAGPAAHVGSATARTWVVEGTEENFNSLLQKSVQHPVLVEFTTPQAHGAKEMESLLRRVTDEAAGKWLLVRVDIDAQPRLAQSLGVKAVPMLVAVIGGQLAPLAQGTIDEQQFRQITEQVIQQRRQRAWWGARNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE94</accession>
    <name>W4TE94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma factor SigB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67106">
        <property type="protein sequence ID" value="GAE67106"/>
        <property type="gene ID" value="JCM18909_143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r1_2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17475" checksum="90B0F68061B1288D" modified="2014-03-19" version="1">MDTKSQVRTTDGIDGKDAVGLYLDGIARTPLLNAAEEVALARRIEAGVFARAVLEGHAETTSDATTEELHQIAADGDEALAHFVRANLRLVVSVARKYGRSQMPLLDLVQEGNTAHTRRREIRLRQGIQVLDLRHLVGPSGYQPRHRAAGSHRPASGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEH8</accession>
    <name>W4TEH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67196">
        <property type="protein sequence ID" value="GAE67196"/>
        <property type="gene ID" value="JCM18909_239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850708" evidence="1">
        <location>
            <begin position="23"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="12503" checksum="B9BA7C0FFBA5D03E" modified="2014-03-19" version="1">MSVLVTVLLPILLISAGVAVDGAERSRAARVAHTVAAEAARAGCEEGFAAQLVGQDGSSAARVAAEASARRAKADGLSQLVIDVNGDAVSVATEITRPTRLLALIGLTEVHGRASEMCTLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEJ2</accession>
    <name>W4TEJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Organic hydroperoxide resistance transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67385">
        <property type="protein sequence ID" value="GAE67385"/>
        <property type="gene ID" value="JCM18909_441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4722" checksum="62DEB6D4B51DB301" modified="2014-03-19" version="1">MHDQTLDLDDQFCFSLYRASRAVTRAYRPLLEGIGLTYPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TES3</accession>
    <name>W4TES3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name evidence="5" type="ORF">JCM18909_57</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67027">
        <property type="protein sequence ID" value="GAE67027"/>
        <property type="gene ID" value="JCM18909_57"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8952" checksum="D7EF30181F72CBD5" modified="2014-03-19" version="1">MADKDQILADMADIVNDITGVDQSEVTLEKSFVDDLDVDSLSMVEIIYACDEKFGVEIPDEESKNIKTVGDAVNYIIEHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEV6</accession>
    <name>W4TEV6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mobile element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67326">
        <property type="protein sequence ID" value="GAE67326"/>
        <property type="gene ID" value="JCM18909_373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16996" checksum="C1BA065044790F4F" modified="2014-03-19" version="1">MDQPATIGALAVAVAQPMGIEVAYLPGLAMRRVADLYPGNAKTDQRDAFIIARAARSIPHTLRTLRALDEDEAELGMLTGFDDDLARQITQTRNRVRGLLTQIHPRLERVIGPRLDHPATLAMLQVWPVPGALKNHHHRHECGSSRYTSPGGNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEY5</accession>
    <name>W4TEY5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66978">
        <property type="protein sequence ID" value="GAE66978"/>
        <property type="gene ID" value="JCM18909_7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE66978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24252" checksum="E6773C5DE5105688" modified="2014-03-19" version="1">MIMAITGTIFALFVFVHMVGNLKAFMGPGDYNAYAEFLRTVLYPLFPVGGVLWCFRIVLLVCLVLHVWAGLTIWVRGRRARGRFSWHNMKALGWGARTMVLSGIVILAFVVVHILDLTLGMGVQSSSFRAPVNEGTPDIHITAYQNLVASLSRPWMAIFYTVVMIIIGLHIAQGVRNTINDFGGTGRRLRAIWTVIGLLIALAIVVCNGALPMLILAGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF25</accession>
    <name>W4TF25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67560">
        <property type="protein sequence ID" value="GAE67560"/>
        <property type="gene ID" value="JCM18909_627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="16396" checksum="345B2BA41237741F" modified="2014-03-19" version="1">MHRMYTHYSCWHFWLSPETSLVAGHGHSGQYNIVLGRILEQLGFQVRPVHAARVRLDHHPWYHTGHSWLRVIHQGKELDVCASRLGNTAGNVAFVPATEVLDRTRLNSIDTTLALAPIVVASVWKSWLTGSGIQSWMYRPFGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF28</accession>
    <name>W4TF28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-galactosidase fused to beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67565">
        <property type="protein sequence ID" value="GAE67565"/>
        <property type="gene ID" value="JCM18909_635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="47" mass="5050" checksum="1225F1B0EE589B6F" modified="2014-03-19" version="1">MTLRVIDRQSARTTWQLESTLNGRTVHTDVEGAYLAGQAVTSGSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF56</accession>
    <name>W4TF56_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S12p Asp88 methylthiotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_93</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67058">
        <property type="protein sequence ID" value="GAE67058"/>
        <property type="gene ID" value="JCM18909_93"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="195" mass="22094" checksum="C46EB6CD27482141" modified="2014-03-19" version="1">MASGCDRRCAFCAIPRFRGSYLSRPIAEIVEEARWLVDHGVKEVFLVSENSSSYGKDLGDLRLLEKLLVNLDQVDGLEWIRVSYLQPAELRPGLIDTILATDKVVPYFDLSFQHASGPLLRRMRRFGDAESFLNIIDSIRSRCPEVGLRSNFITGFPGETDADVAVLADFFTARPPRCCRHLRLLRRGGHRGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFB4</accession>
    <name>W4TFB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67123">
        <property type="protein sequence ID" value="GAE67123"/>
        <property type="gene ID" value="JCM18909_162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="136" mass="15126" checksum="87265AC7A3466D22" modified="2014-03-19" version="1">MSHTDVPADQRKRVFAWAMWDPGTQPFASVITTFVFAVYLVGDAFGSKDRTVTALSWTMTLAGLTIALLAPVVGQWAGRRGRQVTALKWLTWTLAVMSGLLFFRQASSVLSRLRIGAVGHWDGHLGRREFPIQRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFF9</accession>
    <name>W4TFF9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67168">
        <property type="protein sequence ID" value="GAE67168"/>
        <property type="gene ID" value="JCM18909_210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7802" checksum="9DDFA634922A568E" modified="2014-03-19" version="1">MDVAEIESLVRGLAALAPKSVYTDGRYVALNATPAALYGEIRESLDVFDPELVAEYLDTVPKSSDGSEPDLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFI7</accession>
    <name>W4TFI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67292">
        <property type="protein sequence ID" value="GAE67292"/>
        <property type="gene ID" value="JCM18909_338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_alpha" evidence="1">
        <location>
            <begin position="99"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="410" mass="45870" checksum="E169D438B5A683D6" modified="2014-03-19" version="1">MLVTNDSHYVTEDQADAHDSLLCVGVGRNKDDPNRFRFNGSGYYIKSSEQMRALFPDHPEACDNTLLLTEMIGSYDEVFKYVDRMPQFDVPEGETQESWLRKKLQEGLDEKFGPNPPKEVLERLETELSVIEPLGFSSYFLVVSDICNAARSMGVPVGPGRGSAAGSLVAYLTGIIAINPLEHGLLFERFLNPERVNPPDIDLDFDDRQRDKVIDYVTHKYGAEYTSQVNTFGKIKAKAAVKDANRILGYPFALGDKITKAMPPDVMGKGVPLDKIFDSSHERYGEGQEFRQLVADNPDVARLLRLPKASRLIRGTGVHACAFILSSTPLLDLVPMHKRDKDGMIIAGFAYPQLEEMGLMKMDFLGLRNLGIMDHCIKIIKANRGIDVDLKKTSPLMTRQPTRCWRAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFJ6</accession>
    <name>W4TFJ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67208">
        <property type="protein sequence ID" value="GAE67208"/>
        <property type="gene ID" value="JCM18909_252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19858" checksum="69D62C069FAF5A6D" modified="2014-03-19" version="1">MRTVLDNPDLARSLTVVDMAPVDSRLTRLAPLVDAMKSVNLTALTTRRQAEEHMSDGVPDPNIRQFLLQNLRHETGDHERWYWQMNLDLLGNGLSDIGSWPPVTSIWEGPVLWITAEQSDYGGPDHSQAMHELFPQVRRIRVKNSGHWVHSDQPGVFVQVLAAFLSRCQEPLTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFK7</accession>
    <name>W4TFK7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TFK7"/>
    <dbReference type="EnsemblBacteria" id="GAE67556">
        <property type="protein sequence ID" value="GAE67556"/>
        <property type="gene ID" value="JCM18909_623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="30495" checksum="199E6118049CA553" modified="2014-03-19" version="1">MRAPGKWDDGNWHDLVAISGRGAIDLYVDGFLVAHEPGEAFLADLGKVERVTVGKDLEGARLFGEAQTASIFSSALTDAQVKRLANVAPLRTQALFDTGYLGSKSYRIPSLIRLDSGSFIAGADQRVSIANDSPNDINFVIRRSEDGRRWNEAQIVLEYPDEGALGASVIDSVLFQDHNSGRVFCLIDQFPGGVGQPNAEPGSGFDEQGRQLLFDRDATAYVIDAEGIVTTESGEPTDYTVDESGNVFAAGTPRRQYPLGRRSGPPRVPADPTDLQPHPHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS2</accession>
    <name>W4TFS2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67626">
        <property type="protein sequence ID" value="GAE67626"/>
        <property type="gene ID" value="JCM18909_699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848732" evidence="1">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="56"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19027" checksum="EA0E170C6C95F9EA" modified="2014-03-19" version="1">MNVTRTLGAIATIALTLGLGACAGGAQEKASSGYTPALSVTDVAGRTVSFDAQPKRILLAEGRALMATSVLNKENPAKDVVAIGADLHKAALSFESALRQARPQVSKLPMIGSIAKGDVTVENMLSFKPDAVVMTLDQKEAAEKAGFLQKMDQAKLSYVFYRLPQEASRKHHEIDGDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW0</accession>
    <name>W4TFW0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_49</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67019">
        <property type="protein sequence ID" value="GAE67019"/>
        <property type="gene ID" value="JCM18909_49"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8226" checksum="D43DECADB2F1D349" modified="2014-03-19" version="1">MGLSVLSMAIMVLAFAQPKAYHEVPRDRATVVVAIDVSRSMVATDVEPLDFPLLRLLRRISWGICRHGSMFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ6</accession>
    <name>W4TFZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein S12p Asp88 methylthiotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_94</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67059">
        <property type="protein sequence ID" value="GAE67059"/>
        <property type="gene ID" value="JCM18909_94"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11721" checksum="30928FF5F027E6E9" modified="2014-03-19" version="1">MRTSRFWLTFLQRARLDVAGIFAYSDEEGTEAAGLDGHVDEDVITARREDLADLTDELVSQRAEDRIGTRGRVMVEEIDEAVIGRAEHQGWKSMVASPWSTQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG33</accession>
    <name>W4TG33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67104">
        <property type="protein sequence ID" value="GAE67104"/>
        <property type="gene ID" value="JCM18909_141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="298" mass="33055" checksum="7F08C5AE8937B2D7" modified="2014-03-19" version="1">MPSTTAELLDLLDLEDLDLDLFRGRQPHTTWQRTFGGQVLAQALVAGARTIPERTAHSMHALFLHAGRTDLPMIFDVERIRDGRTFSTRRVNARQHGRTIFTAELSFKNREDGPEHSDPMPDYLPDPDRCPTLAQALEQMFGRPMPTVKEWDALDVRLAGDGSQLVDPSHVTHLSLWVRTTASLPDDRVVQRAILAYISDISLMAGAVMPHLGSVPSGMVVNPASLDHAMWFHRTAEADRWMLYDQVSPSVSGLLGFSMGRLMQDGKLIASCCQEGVMRLVDVNDLDASVTFPLGRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG69</accession>
    <name>W4TG69_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67945">
        <property type="protein sequence ID" value="GAE67945"/>
        <property type="gene ID" value="JCM18909_1047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045980">
        <property type="entry name" value="DUF5936"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19359">
        <property type="entry name" value="DUF5936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5936" evidence="8">
        <location>
            <begin position="12"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="157"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="35942" checksum="933E6DE15850C80D" modified="2014-03-19" version="1">MSSLFIGLIPGVVALGAVLLIVRGIYLAASDPSEVLDLDEVALLKKAERDRHAGPLESLAMRFFASGSRRVATCAVSWIQKQVNAAGRPDGMTVDTVLADMLRWAVIVVPLAVFVLVQGMAFIALLALFIPPIIPLGKLTGDVKRRKERIDQDLPSFMDVLAVTVTAGIGFRRALRTVSERYGGPLADEIQLTLQHIDNGASMRQAFTALRDRTGSAAVDEFVSAYVQSEELGAPLVDTLNHIAADMRRSSAQAALQRASRIEPRVSLVTTTVMVPGILVLLIGGLLIGTGMLHQISGDVQMIAPSRPVAGWSQLVRLSRAAWHFASWRSSSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI8</accession>
    <name>W4TGI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67647">
        <property type="protein sequence ID" value="GAE67647"/>
        <property type="gene ID" value="JCM18909_721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10786" checksum="658F94F2BBBED5A7" modified="2014-03-19" version="1">MTGRIGSPLRLQAGVMIVFAAFGASLQPWYLIGPLALLASVQLRRTHRDAVIGGVVATAILTMMQWYWSPYVCLPLVIVGYLIVWRIPKAWAFVTAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN8</accession>
    <name>W4TGN8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67588">
        <property type="protein sequence ID" value="GAE67588"/>
        <property type="gene ID" value="JCM18909_660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850722" evidence="1">
        <location>
            <begin position="25"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="15863" checksum="9D34EE7B37B8194E" modified="2014-03-19" version="1">MKRALIAGVAALVGLAALTPPAVADDSVAPVGAHALASAQPRNAGHRLQDIRTWSPQTDPYARYLRAEVPLQPRIPHDPSTQAHPELDAKAQVMLMQGDYGNSFFGNFRANDGFAHNVLNFWQYATTGAPGTAQQPHGLHSPSIPCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP6</accession>
    <name>W4TGP6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hemolysins and related proteins containing CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_786</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67707">
        <property type="protein sequence ID" value="GAE67707"/>
        <property type="gene ID" value="JCM18909_786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="155"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="219"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="397" mass="42700" checksum="A7857B8B0F634CEE" modified="2014-03-19" version="1">MQIGVTLSGFLASAFGGATLASELAPVFESWGMSASVAATVALVTITVIISYFSIVLGELVAKRLAMQRAEGFSVALGPMVNGIATLFRPIIWFLGVSTDLVVKILGGDPTAAREEVTDEEIRSMVVSSATLGDEERTILDEVFAVGEKSLREVMVPRTEVDFLQGSMKAVQAAQVVRDGSHSRYPVIDGSADRVLGFVHVRDLLELDPQIRTSRVSQLVRTVVSLPDTVKVLKALTEMRRTNAHLAIVLDEYGGTAGIVTLEDLVEEIVGDITDEYDTVEPSDLAHVRQRDIDGLTTLEEFSDKVGLVLPEGPYDTLAGYFMAQTGEVPTKGAQVDVHLDPVGYVPDEDDEDVEPDPNIELTVTEVDGLRAAWLRIRRLDAPGAPTVPAGASAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT4</accession>
    <name>W4TGT4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67971">
        <property type="protein sequence ID" value="GAE67971"/>
        <property type="gene ID" value="JCM18909_1073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16731" checksum="CC1B3CE9759C2607" modified="2014-03-19" version="1">MRNSVLQLLQGYQGDERQAATSGAPEAGPQQSSATILDQFGRNLTEAARDGELDPVIGREREIERVMVVLSRRTKNNPVLIGEPGVGKSACVEGLAQAIVRGDVPETLRDKKIYSLDLGSMVAGSRYRGDFEERMKKVLKEIKKPRGHHPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ8</accession>
    <name>W4TGZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NagD-like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68240">
        <property type="protein sequence ID" value="GAE68240"/>
        <property type="gene ID" value="JCM18909_1363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4246" checksum="781C01625C9F6DAB" modified="2014-03-19" version="1">MLTVLVLSGITKREEVEQYPYRPNIILDSVADLNELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH33</accession>
    <name>W4TH33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67429">
        <property type="protein sequence ID" value="GAE67429"/>
        <property type="gene ID" value="JCM18909_489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="238" mass="25294" checksum="B6CA6F660D8390FD" modified="2014-03-19" version="1">MKGVRLALRLSRGAGRHERVRSLVMIVGVALATLGLAVGVTLPRVTAQQQEVRDARTPILAPDEPADGHTGFKVQELQVDGTPWTSFVVNHPADRLPPGLKHWPQPGHTIVSPRLKSLMDAGVVKISSLGTIDPVAVDRAALASPDELFSITTTPDQAGCRELKAFGLTRIGDSGVSSRTVWIEVIGLVALPAAVLLWTSLSLSAASRRDRFMTLVRMGCDPDWCGQVSAVEVSGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG6</accession>
    <name>W4THG6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67937">
        <property type="protein sequence ID" value="GAE67937"/>
        <property type="gene ID" value="JCM18909_1038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="21969" checksum="AF06B4A4BF5BED0E" modified="2014-03-19" version="1">MFSAVGGPVAATVGVMTGLAEGTLILAFVTPRRYRYGDEADLPVRSRWWVPVWTVFACVSLAFFSWWHAPAYMAIVLALVVPMVAACVVDADVQRLPDAITLTTAAVLAVALGILAAITSAWSAFGRSLGAGFLVFLVFFSRWPSSVEAAAWEWAMSSCRCLSASWTDTCRRYTCFFCHAGGRAHWITLGSETACRQRTRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ3</accession>
    <name>W4THJ3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ORF">JCM18909_1390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68266">
        <property type="protein sequence ID" value="GAE68266"/>
        <property type="gene ID" value="JCM18909_1390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14077" checksum="A79E17D7EFBE01B9" modified="2014-03-19" version="1">MVTQGGEMNGYAPLVGMVILGAVFVLAAITVNVLLAVKRPNRAKHEIYECGIEPTPQPAGGGKFPVKFFVVAMLYIVFDIDIMFLYPWAVDFNRLGVFALVEMVLFVAMVFIPYLYIRRRGGLDWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ6</accession>
    <name>W4THJ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:alanine symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_717</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67644">
        <property type="protein sequence ID" value="GAE67644"/>
        <property type="gene ID" value="JCM18909_717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="313" mass="32192" checksum="13AD4C903C94E2BC" modified="2014-03-19" version="1">MPLGIMTSPVSTSLEALVPTPLSLDQAIDNIISPIATAISDAVFWAIPLPGGNEFPLILAWLLGAGLFFTIYLDFQQLRPASIRHSSHVMRGHFSRHTDPGDVTSFQALATELSGTVGLGNIAGVAIAIATGGPGASFWIAVAGLVGMSVKMAEATLGVKFRVINEDGTTSGGPMYYLRDGLASIGKPALGRVLASLFAICTAFGVIGAGNMFQSNQAAYQLAMFAGGQDSWIGTHMWVVGVVFAILVGIVIVGGASKIGAATSKIVPFMGILYVIMCLAVIGVNISQVGSAFEAIWSGAFTGHGVTGGSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK5</accession>
    <name>W4THK5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68281">
        <property type="protein sequence ID" value="GAE68281"/>
        <property type="gene ID" value="JCM18909_1405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9357" checksum="7B6DA9D65F8D179E" modified="2014-03-19" version="1">MLPGAPSSIKDGVETRSFLVVVGVILVALIVWAFMGGKTDSTADEAPDEPFDAFAGGYPVPPLPHQVQAPLAGAATATTVARRDHDENGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT0</accession>
    <name>W4THT0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTP-glucose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68495">
        <property type="protein sequence ID" value="GAE68495"/>
        <property type="gene ID" value="JCM18909_1637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16050" checksum="8E113EEDD1CDE1EF" modified="2014-03-19" version="1">MAQTAPHKVVIMARGLGTRMRKSVEGVSLTADQAAAASAGVKAMISLDDRPFLDYVISALADAGFDEFCLVIGPEHNVIRDYYDSCEKKSRLSIVYAVQEHPLGTADAVAAAEEFAGDDRVLVVNSDNFFTRRTRSPDFVRFPPQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI40</accession>
    <name>W4TI40_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">23S rRNA (Guanine-N-2-)-methyltransferase RmG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67829">
        <property type="protein sequence ID" value="GAE67829"/>
        <property type="gene ID" value="JCM18909_916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="188"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="362" mass="39487" checksum="D69BDA9C41194B69" modified="2014-03-19" version="1">MLTLPSVLIDSSEQHRHVGPLPIWETATMDAATRDPVDELISAESPHADSVWVLGRPSLVHVAEGRVAAWADDCRDLADIPEAIRLNPLSAGDVSDRPVVWMGLPASLDELDELLGTLWRILGPETHIVAGGRIKHMSRSMNDVAARWFNEVHASLGVRKARVLHFSSPRQRPAITGTWPRTNTVNGLTIRAHGGVFHTVGVDAGTSLLLDYLDAIAADVHSDAVDLGCGNGVISAHLARLLPQATIHATDVSWQAVDSTRLTAQANQLNIVTHWCDGLADVPHESVDVVVTNPPFHRGTAQDHAPTLAMLADAARVLRPGGTLWCVYNNHLPWASHVQRTIGPTRQVVRNRRYTVIRTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI95</accession>
    <name>W4TI95_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminopeptidase YpdF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68153">
        <property type="protein sequence ID" value="GAE68153"/>
        <property type="gene ID" value="JCM18909_1272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6089" checksum="8262D115773700AA" modified="2014-03-19" version="1">MALGAASWRVRAWLGGEQLGIGDSADLLVLDRDPRVDVGVLESPTYIVLRGRVVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC0</accession>
    <name>W4TIC0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium efflux system KefA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68511">
        <property type="protein sequence ID" value="GAE68511"/>
        <property type="gene ID" value="JCM18909_1654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27594" checksum="217BC27E92432441" modified="2014-03-19" version="1">MIGRFISWCRVPRNAKRRCQAAHVASSQRRPARASIDKKQRTATVGGLLSNVGVTIIIIVALLSGFSTIGFKITPILTSAGIVGVALAFGAQTLVKDVLAGLFIIFEDQYGVGDAVKINEVEGLVEDVGLRVTRIRDWNGAAWYLRNGEITKVGNVTQGWTTSFTDINVHALEDPNQVIRVIRKVLDNLEVEFEGTLLDKPLMLGVGDITGDTMTFQVMTKCIANQHNNVLRALRRECKDAFDAARIRRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE6</accession>
    <name>W4TIE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate-flavodoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68307">
        <property type="protein sequence ID" value="GAE68307"/>
        <property type="gene ID" value="JCM18909_1435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="207" mass="22517" checksum="2FF02075AACB934A" modified="2014-03-19" version="1">MRPSRRSRIRFKRPTVKKSQKIVEMNHAAVDASLEHLHQVKVPGQMTANHSLIPAVREDSPEFVKNVTARMIEGFGDLLPVSALPDDGTYPAGTTKYEQRTLSDVIATWEPNACIQCGNCAFVCPHGVIRSKYYPQSQLEGAPESFQSAELNAAGLPESCYTLQVVPDQCTGCGLCVEAARPTQSGNLTARPSTLKSTSTRPSSART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ2</accession>
    <name>W4TIQ2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="7" type="ORF">JCM18909_1537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68402">
        <property type="protein sequence ID" value="GAE68402"/>
        <property type="gene ID" value="JCM18909_1537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="371" mass="41480" checksum="4B1F96DCC61C1716" modified="2014-03-19" version="1">MLNVALVDLQQTVEDLDASLSSIENVLDPEAKKAEIADLERQVAVPNLWDDQENAQRVTSRLSALQAEIERLERLRARIEDVHVLLEFAAADDDKESLAEATTETVKLREEIDALEVRTLLSGQYDEREAVVTIRSEAGGVDAADFAEMLLRMYLRWSERHGYKVEILDTSYAEEAGIKSATFVVHAPFAYGTLSVEQGTHRLVRISPFDNQGRRQTSFAGVEVLPVVEETDHVDIPESDLRVDVFHASGPGGQGVNTTDSAVRLTHLPTGIVVSCQNERSQIQNKAAALRVLQAKLLEKAREEQEAEMNSLKSEGNSWGAQMRSYVLHPYQMVKDLRTNHEVGNTDAVFDGDIDDFIDAGIRWRRKNEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU9</accession>
    <name>W4TIU9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68442">
        <property type="protein sequence ID" value="GAE68442"/>
        <property type="gene ID" value="JCM18909_1580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019639">
        <property type="entry name" value="DUF2505"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10698">
        <property type="entry name" value="DUF2505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16431" checksum="0ECCCFC5E126C0AC" modified="2014-03-19" version="1">MDINLRAHFDATPDQVVTMMTDPAWWQDVHRRGGGTTSNAAVTGDSLSLDVAMPAPSQITKFVGSTLTAKQTLSWQPAGPNGSREGTLQIVPQGMPAKADGHASVRPDATGTEVIYTGTFTVSVPLVGKKLEKKPQLLVSLRRLMCNRMLATTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIW9</accession>
    <name>W4TIW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68900">
        <property type="protein sequence ID" value="GAE68900"/>
        <property type="gene ID" value="JCM18909_2072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9223" checksum="28E79C303A38B390" modified="2014-03-19" version="1">MRAPRYSGIFALMSYARISPQPTNIKAAITAPKTFIPLIDAAPGLTWRPPRDPLDLPRRRGTARQPGIPRRQDAASDSAASRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ71</accession>
    <name>W4TJ71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate-protein phosphotransferase of PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68995">
        <property type="protein sequence ID" value="GAE68995"/>
        <property type="gene ID" value="JCM18909_2174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilizers_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="15257" checksum="73B1193126DD5D54" modified="2014-03-19" version="1">MVEVPSTALRSSQVLESVDFASIGTNDLTQYAMAADRLQGELAELLTPWQPAVIQLVKATCDGAGDRLIGVCGEAAGDPLLALVLVGVGVRSLSMAAGKITAVKAALSRHSLEQCRRIADAALAACSPEEARTAALELADPSVEVLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ99</accession>
    <name>W4TJ99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69025">
        <property type="protein sequence ID" value="GAE69025"/>
        <property type="gene ID" value="JCM18909_2206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18871" checksum="A272508CC50A5424" modified="2014-03-19" version="1">MFTLTSTPVTFIGLLILFAWSLVWSVRDAIKAPTVVTRISTWVHVVMAVTMILMVPKSWWKPIVPAIGGPITPVIIFAICTAWMVFMAAWRSSWSSWGHAAMFAAMVWHLVAMRKMSSLMTAPRDSGMGQMNHTHSGMHGPGMQTAMNAAMHDYAVVGVPLMVALLAMAVAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA8</accession>
    <name>W4TJA8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68493">
        <property type="protein sequence ID" value="GAE68493"/>
        <property type="gene ID" value="JCM18909_1635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="6">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="92"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="18744" checksum="B877F7789B5BC02C" modified="2014-03-19" version="1">MTRWFVPGRIEVLGKHTDYAGGSTLVAAVDRGVTISIEPGDSEITVSTDAAPGELSLAAGHDPKLPAGHWGRYAQAVVDRLAANFGDLVPARIRLTSDLPLASGMSSSSALVSAIVLGLADFNGLPDTRTWQDNITDDADLAGYLACHENGMTFKNLVGAAGVGTFWRFRGPHRNGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJF7</accession>
    <name>W4TJF7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arabinose operon protein AraL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68553">
        <property type="protein sequence ID" value="GAE68553"/>
        <property type="gene ID" value="JCM18909_1699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6534" checksum="2D11C227E20768AA" modified="2014-03-19" version="1">MHDVIDVPTDFARAYVFDMDGTIYLGEHLLPGARRMIEELRRREIPVRFFVEQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG1</accession>
    <name>W4TJG1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proA</name>
        <name evidence="9" type="ORF">JCM18909_1705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68558">
        <property type="protein sequence ID" value="GAE68558"/>
        <property type="gene ID" value="JCM18909_1705"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="100"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="364" mass="39012" checksum="027D1BA42C446C0E" modified="2014-03-19" version="1">MAMSSRVIEQAIAARSAATVLRRLRRIDKDDLLAAMAIGLRKGVDEILAANRADVDRGRDAGIDEALLDRLTLVPERIEGMAVGLEGVARLDDPVGEVVRGWHTPLGVKVEQVRVPIGVIGIIYEARPNVTSDAAGICLKSGNVCLLRGSSSALESNRAVIAAMRSRLPEEIREAVQLVEGGHEVTDELMAARGYVDLLIPRGGAGLINAVVTGAKVPVIQTGTGNCHLVIDVSADVEMAVNIAVNAKTQRPSVCNAIETVLVHRGIASSAVPPLVDAMNERGVTVHGDEESIRLDPRIVPAAPDEYDNEYLSLDLALRIVDDLEEAVDHIAKHGSGHSETIVTKSMSSQEFFSLQALMLRRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK5</accession>
    <name>W4TJK5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68603">
        <property type="protein sequence ID" value="GAE68603"/>
        <property type="gene ID" value="JCM18909_1750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21909" checksum="145E7EF9645F10A1" modified="2014-03-19" version="1">MHVHAYVWIITILVMGALLFFDVLVLGRNPHIPSAKECATFVGVFVGLAVFFGLGVWILQGHAAGGQFFAVWLTEYSLSIDNLFIFLILMEKFNVPRKLQQFALLVGIIVALVFRGIFLSLWDRLFLRPGRGCSSSLVLSCCIRQLTRCVSIDTVTMTTMRILVRMAASWRGSGTRFRLLVTTVARSFFRSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY5</accession>
    <name>W4TJY5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ORF">JCM18909_2469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TJY5"/>
    <dbReference type="EnsemblBacteria" id="GAE69270">
        <property type="protein sequence ID" value="GAE69270"/>
        <property type="gene ID" value="JCM18909_2469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16118" checksum="156E2C1464EE3582" modified="2014-03-19" version="1">MKLILTAPVAKLGVPGDIVEVKDGYGRNYLLPQNYAIKWTRGAEAQIKDITRARKAKEIKSKEEAEQIRSQLEHLVVQVTVQVGENGRLFGAVTPGDIALAVRKAGGPALEKRSIEITKPIKTIGKHTVGVKLHDAIKGHVTVETVPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK35</accession>
    <name>W4TK35_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69315">
        <property type="protein sequence ID" value="GAE69315"/>
        <property type="gene ID" value="JCM18909_2516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="226" mass="24062" checksum="3A761A1015B96F3F" modified="2014-03-19" version="1">MAIFACRMIAVGNLEGALWRLSMLMAIANPIDLVREYVEGNTTGWRVATRLGGAAICHVLLILALAVAVDAVIRYRHRILSSVAAVSHLACLAASGSRAGTISLALFVIGLVFFGRSYRTRSRKQRTVIAVLGIVASGVAIWLVTTVRSGSLVDPARARTWALAGRVVVDSPSHFLVGTGYGTIWPWFAVESTFMPESSTGCAELFMVTASHTPTASSSRLSVSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK67</accession>
    <name>W4TK67_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69196">
        <property type="protein sequence ID" value="GAE69196"/>
        <property type="gene ID" value="JCM18909_2388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="281" mass="31771" checksum="DA9ED62A27044F8B" modified="2014-03-19" version="1">MPTTDLEIILYPELFDEKRRDVLRTGEWIVTAWRYPTGIAALRITNSRGYIEALPFMGQILWDAVFDGQSLRMDNMFDMPVPARQIVETYGCFAFHSGLLAAGCPSPEDDHPLHGEFPCAPMRSASLVTRHESCGVTAVTLSSEYEYRIGFGHHYVARPTVTLRAGSAMFNIGLEVTNLAKYQSMPLQYMCHMNYAFIPEARMNQSLPDGAFQLRRSVPNHVTPTHQCSGLMRTFSLERSMLTRWSVPRHSIPRSCISQTTYRNTARLPSLECKPVLITTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC0</accession>
    <name>W4TKC0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding alcohol dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69246">
        <property type="protein sequence ID" value="GAE69246"/>
        <property type="gene ID" value="JCM18909_2442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08252">
        <property type="entry name" value="AL_MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014182">
        <property type="entry name" value="ADH_Zn_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="11"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="259" mass="27040" checksum="91F250526C1F1FAE" modified="2014-03-19" version="1">MHAVAITGPLPVSDPECFVDVDLPVPEPGPHDLLVEVQAVSVNPIDIKLRKGAGTLSHPRVLGFDAASVVRAVGSEVNGFSVGDEVWHSGNRDRPGTYSQFALVDSRIVSKRPPSLSIAEAASLPLTALTSWEALIDHIHLGTPEERSNKAFLMIGGAGGVGSAAIQLARAITSGPVVATSSRPESAQWCQDMGATGIINHREPLAPQVNDLGIAGFDGILSAYTPPASTLAEIIAPFGHLVMIDGTDSFDLMASSQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC6</accession>
    <name>W4TKC6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68604">
        <property type="protein sequence ID" value="GAE68604"/>
        <property type="gene ID" value="JCM18909_1751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7833" checksum="5678DD8AABFB33F9" modified="2014-03-19" version="1">MITDEQRAAQGKRLDVSKMAEEDLGKLIVDLTTEMRSAAGELKFEVAARLRDEIADLKKELRQMVEANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD7</accession>
    <name>W4TKD7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69261">
        <property type="protein sequence ID" value="GAE69261"/>
        <property type="gene ID" value="JCM18909_2458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="19640" checksum="3293072169007B0D" modified="2014-03-19" version="1">MTKWIIGGHVDTADAVAQAAARGADIAQISLGDPKSWKKPVCDFPGGSLALREAAGEAELTLVVHSAFVINVASLNNRIRIPSRKLLQQTLDVAAEVGAMGVVVHGGHVRAGEPIEKGQDNWRKAIDGLEMSVPLFVENTAGGDNAMARFLERLSVLGRPSVPRQGTRMSDSVWIPATLSRPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI0</accession>
    <name>W4TKI0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_2507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69306">
        <property type="protein sequence ID" value="GAE69306"/>
        <property type="gene ID" value="JCM18909_2507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE69306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="16534" checksum="8E67A6B00AEE5FD1" modified="2014-03-19" version="1">MMCSDLGGPINKAAYLFATTNLAVTNVGSLKVMAAVMAAGMVPPLAMALSTTLRPKLYQPAERENGTAAWLLGASFISEGAIPFAAADPLRVIPSMMVGGATTGALSMALGAASKAPHGGIFVFFAIDRIWAFILAIVVGTLVAALLVTALKASARRKAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL8</accession>
    <name>W4TKL8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsZ</name>
        <name evidence="10" type="ORF">JCM18909_1855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68704">
        <property type="protein sequence ID" value="GAE68704"/>
        <property type="gene ID" value="JCM18909_1855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="8">
        <location>
            <begin position="11"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="9">
        <location>
            <begin position="205"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="19"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="416" mass="43549" checksum="F085A809B8E4E985" modified="2014-03-19" version="1">MAIPSQNYLAVIKVVGVGGGGCNAVNRMIEAGLKGVEFLAVNTDAQALLTSDADVKLDIGRDLTRGLGAGADPDKGRQAAEDHADEIEESLKGADMVFVTAGEGGGTGTGAAPVVAKIGRSLGALTIGVVTRPFSFEGHRRSSQAEQGIDNLRDEVDTLIVIPNDKLLDMTDQQIAILDAFKQADQVLMQGVSGITDLITTPGQINLDFADVKSVMSNAGSALMGIGRASGEDRARAAAETAISSPLLEVSIDGARGVLLSIAGGSDLGLFEVASAANLIEAAAHDEANIIFGTIIDDALGDEVRVTVIAAGFENGQTTSTKQPGISQRPASRPAMSNRSSAGIFLALEWVLLHQLRLGRVRLRVVSPLTASSRRRSVRRPKAARSERPSRRSRVVSWSLLIHLGSRMTTLISLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY4</accession>
    <name>W4TKY4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SSU ribosomal protein S7p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69098">
        <property type="protein sequence ID" value="GAE69098"/>
        <property type="gene ID" value="JCM18909_2285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="4917" checksum="75A48EA4C20A1E43" modified="2014-03-19" version="1">MPRKGPAPKRPVMVDPVYGSPLVSQLVSKILLDGKKTVARTSSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ6</accession>
    <name>W4TKZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nicotinate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68834">
        <property type="protein sequence ID" value="GAE68834"/>
        <property type="gene ID" value="JCM18909_1998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5798" checksum="0A7A0A933BD4D5E4" modified="2014-03-19" version="1">MGREPLEAARKRHQAAIAELPISGRRISRGDQAIPTVMVKQGNDGADTVLGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL19</accession>
    <name>W4TL19_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integration host factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69232">
        <property type="protein sequence ID" value="GAE69232"/>
        <property type="gene ID" value="JCM18909_2426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11727" checksum="83A5A9E83080517E" modified="2014-03-19" version="1">MSIPTLSSEQLSAAREAATRARRVRADFKAKVRSGDITLSEALDKAANDEVLAHVKVVDLLKALPRVGDKRAAEIMERLEIAPNRRIRGLGRHQIAGLRAEFDQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL42</accession>
    <name>W4TL42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium and cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69446">
        <property type="protein sequence ID" value="GAE69446"/>
        <property type="gene ID" value="JCM18909_2661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNNM transmembrane" evidence="1">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="15922" checksum="D93A4BF760BC2177" modified="2014-03-19" version="1">MDRSGDRFIFTVLASLNVAMETALQHMSHSKAEELAADGKAAHQRVLDMVADPAPLINTAMLVRVISEVTATALVALLIFGHFDLPWQQVLVVVASWCLLTSWHGEWLRAPWGASMTPLSAPSGLVLGEYLPTSLAPSRPCLSSSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL72</accession>
    <name>W4TL72_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2705</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69486">
        <property type="protein sequence ID" value="GAE69486"/>
        <property type="gene ID" value="JCM18909_2705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="312" mass="34263" checksum="E213B7240616A789" modified="2014-03-19" version="1">MTHADNSLPELHPAGGPWSIYLHVPFCASRCGYCDFNTYVLSAMGDDAVAGHLDAAHRELELAANALGDAQPPVSTIFFGGGTPTMLSPVQLGELIDHIRTLWGIDSDAEVTTEANPETLSAEVLADLLKAGINRLSMGMQSADEYVLTVLDRRHRPGRAVEMAQLARQVGFDDVSLDLIFGTPGENLDSWRHSLDAALTAKPDHISAYSLIVEKGTRLAGRIRRGELPMTDEDDLADKYLLTEKILTEAGYVNYEVSNWARPRSGRDHRCRHNMAYWLGYDWWGIGPGLILTLLARGVECQTPCHLPERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB1</accession>
    <name>W4TLB1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69531">
        <property type="protein sequence ID" value="GAE69531"/>
        <property type="gene ID" value="JCM18909_2757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10666" checksum="F222CB2985C10EBF" modified="2014-03-19" version="1">MATVGHMYDSVEHLPAADHPELLAATVAGRVAELPSAVIFSIDPEIADTEALCEAFGEGPETCANCVIVRGKRGDIEKYVACLVLATTRVDVNKVVRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD5</accession>
    <name>W4TLD5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69556">
        <property type="protein sequence ID" value="GAE69556"/>
        <property type="gene ID" value="JCM18909_2785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="379" mass="41264" checksum="329FDAEA93797B57" modified="2014-03-19" version="1">MQFSESADHVREQAKQIAASDPEHSKRLFSFANQIAGMASQVDRLVPLVFLVIVCTVAIYGLGIGRLAEKLGLASASPRGVMFAGSPAWTIDTAKTLRDLDVPTLIVTRRAYDLYAARKAGLRCEAADFLSEYATEDMDLAGIASMVACTPDDDTNSIASVHYRRALGRANVFQLERMDERDDGDATTGTAQILKARTAFDPPTSHSAMDKMWRNGKRVRRVKLDENRNWEKFRETMPDAVVMFVVKPSSVNVATNGMNAPKEDDTIIYLGDEWKDAPEPVAAQEEQPSRQTMSVPSSEEAVRDRIDADRRAAEGTNKAAVSVTAGDPADTTVDHGDKGGKSEQTSEASGGGEDPVRPRFDELNPGRPSPVSADSPSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE8</accession>
    <name>W4TLE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69805">
        <property type="protein sequence ID" value="GAE69805"/>
        <property type="gene ID" value="JCM18909_3060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12218" checksum="41CC45199C3AD57B" modified="2014-03-19" version="1">MITGLGIGDRLKHRPSELSGGQQQRVACARAMITQPHVVFADEPTGALDSKSGANLLGYLRHCVDDLGQTIIMVTHDAKAASYADRALMLLDGRIVDDIASPTAESVSEAMAGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG2</accession>
    <name>W4TLG2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69278">
        <property type="protein sequence ID" value="GAE69278"/>
        <property type="gene ID" value="JCM18909_2478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019060">
        <property type="entry name" value="DUF2382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09557">
        <property type="entry name" value="DUF2382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="2">
        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2382" evidence="3">
        <location>
            <begin position="158"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="222" mass="24219" checksum="D6152070AFFE9104" modified="2014-03-19" version="1">MTNDKTPTNATIDALYDRSVVDQSGNKIGEIGQVYLDDASGQPAWVTVKTGLFGRNETFVPFKGLETSGDQIRAPYTKDKVKDAPNVDPDGHLSEDETDELYRYYSDTFASDAKAADTNTNQGVAGQKVAGTESAADTKAQTTADQKSPVAGDGSVVRHEERLNVGKERVETGRMRIRKHVVHDTETVEVPVEREEVHVERVPLDEKVAADDAKLSEAPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI8</accession>
    <name>W4TLI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Manganese ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69845">
        <property type="protein sequence ID" value="GAE69845"/>
        <property type="gene ID" value="JCM18909_3103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022392">
        <property type="entry name" value="Anch_rpt-typ_ABC_trnsprt_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03770">
        <property type="entry name" value="anch_rpt_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="312" mass="32587" checksum="BA09D7938F50A852" modified="2014-03-19" version="1">MLSPLDFLSDLTNPLLSFLPKALLVAMVCSVVSGVIGSHVVLRGMAFIGDAVAHSVFPGLAVAFLMQGSLLLGGSIAGLTTAILVAIVSQNRRLKEDSVIGILFAGAFALGIVIISRAPGYSGSLQQFLFGSITGITDDDIVIVCVAGALVLALEWAVHKELVTVGLDRETARAANLPVFALDLLLYVLVTMTVVISVQVIGNVLVLALLVTPAATARLLTDRLGQMMVLAPVIGGFSALVGLYLSWSIDLPAGGTIVLVATAVFLACWLVAPRGLLALRLDCTAPHHRHARVADDTHRAHLEVGSHVADPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR9</accession>
    <name>W4TLR9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpX chaperone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69373">
        <property type="protein sequence ID" value="GAE69373"/>
        <property type="gene ID" value="JCM18909_2582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14642" checksum="2ED289CCCF6F11F7" modified="2014-03-19" version="1">MARIGESGDLFKCSFCGKSQKQVKKLIAGPGVYICDECIELCNEIIEEEISSSDEAGGVEDLPRPRELCEFLDAWVIGQEEAKRTLSVAVYNHYKRIQSEANVSHARRAETTGWSSVSRISSCLGRLAAAKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM43</accession>
    <name>W4TM43_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69806">
        <property type="protein sequence ID" value="GAE69806"/>
        <property type="gene ID" value="JCM18909_3061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10648" checksum="7453AE23BD57B2E2" modified="2014-03-19" version="1">MFTEALRELRHHPGRMVATLVAIAVSVGFLVGISMFVRTQGVALGKEQAVATSKADVVVDTNGAVVDPDEVTRTIKETQGVGAVDTVLSRPCQQLTDTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM46</accession>
    <name>W4TM46_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="16">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JCM18909_2461</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69264">
        <property type="protein sequence ID" value="GAE69264"/>
        <property type="gene ID" value="JCM18909_2461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="14">
        <location>
            <begin position="28"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="15">
        <location>
            <begin position="160"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GAE69264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="519" mass="53548" checksum="EF1EF6CD7F8AD8F0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM76</accession>
    <name>W4TM76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69831">
        <property type="protein sequence ID" value="GAE69831"/>
        <property type="gene ID" value="JCM18909_3087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17679" checksum="C3644B1C37834163" modified="2014-03-19" version="1">MARSGKKLGHFGDDRIRIEVDQAAIAKAPEDSIMVNPQDGTPVVSKGSSIVLVRYIVTNVSKAPINLGLGTVTITARYPDWTWRQPLVSVLAPRADAAHKIVTTPFAPGTARPPYVLGPGESFMVGANYPYETAEQLDVTATVVVCDTAGAVDPGLGWTITGKVHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM94</accession>
    <name>W4TM94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69314">
        <property type="protein sequence ID" value="GAE69314"/>
        <property type="gene ID" value="JCM18909_2515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5662" checksum="E9E5F4419A111F87" modified="2014-03-19" version="1">MPAFLMDTYLIKNFPVALFWWISTLALCRLVTTGDADVEGGSGYREEKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD9</accession>
    <name>W4TMD9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69702">
        <property type="protein sequence ID" value="GAE69702"/>
        <property type="gene ID" value="JCM18909_2951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8277" checksum="2AB8A2ABEB81EAE1" modified="2014-03-19" version="1">MTSPQRCYSKKHGVFTVGTSIEKAIKAAVMVEDVAKTLTYAKLIGEISPLPQSEIDSNHDRYTNRYGTAAASTGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME9</accession>
    <name>W4TME9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69588">
        <property type="protein sequence ID" value="GAE69588"/>
        <property type="gene ID" value="JCM18909_2822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5925" checksum="46BC27D60173ED76" modified="2014-03-19" version="1">MTAITNYEPAFQRLRDQRGTKVILTGGRYLSWADAFVGPLTTHTSRACAPTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU2</accession>
    <name>W4TMU2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LtrC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69504">
        <property type="protein sequence ID" value="GAE69504"/>
        <property type="gene ID" value="JCM18909_2726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8440" checksum="4631C15636EF5DD3" modified="2014-03-19" version="1">MHAGITPTEYYEHRGQCEVEAESVVHVVAGILGLDTSAYSVGYVAGWPKGDAELIRQSASRVLAAAHRIAEAIIEDSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW7</accession>
    <name>W4TMW7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69758">
        <property type="protein sequence ID" value="GAE69758"/>
        <property type="gene ID" value="JCM18909_3009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23989" checksum="4F505DDF166DCCBE" modified="2014-03-19" version="1">MKLRRWAEARFSVPVHHHRRPRWRSPFHPLYKPNVECSMLPTGWPTPHDVEDLVCGRYIESDRSARCWRLVNEWLTHLSWGWAEIPMSVARFEELDRDLAAAGLPSTYSLKRLMDEDPQIPLRPAPGMKIGYAGTRQILATWVELSEVIGTVPIARRGEVNAVLKFLSSYPGWNHLAVDLGRPAPGLLVVWQPDTVEDARPTGLRAGRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY3</accession>
    <name>W4TMY3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70081">
        <property type="protein sequence ID" value="GAE70081"/>
        <property type="gene ID" value="JCM18909_3367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23933" checksum="26B756142A6BC7F7" modified="2014-03-19" version="1">MRSIVGATLGFGHGELDHHSDSCDIYSTVSRCLDDTVEHFGLVIAKEELYGSVSKHVGRLMAHAPSMPYFRNTLRESLRSRSPFLYDAAVYLADKLSRLLGIFFTDDEIGLLAIYIGLYSEPAPNPNLVTAVVVCPRYQALRDVLLAGLVDHFANRMRMCGHRFICRGSGYVRWRHRDIDDRRTVAPPYLCSHQRVDVGSRSVGDRFCAPEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ3</accession>
    <name>W4TMZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-damage-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70345">
        <property type="protein sequence ID" value="GAE70345"/>
        <property type="gene ID" value="JCM18909_3659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11351" checksum="F323BF0A3CD634DD" modified="2014-03-19" version="1">MTRWGLVAGVVIGIVLAAFHQVVPALYTDDPAVHRAVAAGLLVVAAQQIVAGPAFVLDGVLIGAGDGRWLSGAQVVMLLVYLPMAWAVHLLAPSDPAAAVVWLWVAFSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN15</accession>
    <name>W4TN15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">rRNA small subunit 7-methylguanosine (M7G) methyltransferase GidB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70121">
        <property type="protein sequence ID" value="GAE70121"/>
        <property type="gene ID" value="JCM18909_3415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6613" checksum="841E7BB125FB9D97" modified="2014-03-19" version="1">MFGMTLVSDDAIAERLYRDNYKTIRKYVDILASRGVDWGLIGLGRLADCGSAHPEQYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN21</accession>
    <name>W4TN21_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="2">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69813">
        <property type="protein sequence ID" value="GAE69813"/>
        <property type="gene ID" value="JCM18909_3068"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="29106" checksum="64A16ADB57BEADF7" modified="2014-03-19" version="1">MRRLPAHRAGFGADMGAERFFNIKCRIGGMRPDAAVLVATVRALKTHAGRYNVIPGKPLPSAMLEDNPNDVLAGAANLRKHIEIVREFGVSPVVALNVFPTDHPDEIDAVRKVAEAAGAHFASSTHVVDGGDGAVDLAHAVVAACDHKADFRYTYDLEDSLVEKLTKVATKVYGADGIDIAPAAAKELAHFEDLGYGTFPVVIAKTHLSLSHDPSLKGAPTGWRLPVREVRAAVGAGYIYAICGDMRTMPGLGRHPAAERIDIDDNGETIGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN32</accession>
    <name>W4TN32_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69922">
        <property type="protein sequence ID" value="GAE69922"/>
        <property type="gene ID" value="JCM18909_3190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="27419" checksum="D0E231B5B65E2613" modified="2014-03-19" version="1">MSNEQGIRLQKVLAQAGLASRRAAEDMIAAGRVEVNGELIVEQGRRVDPERDEIRVDGSRIPTARRHVYYVLNKPQGVVSTMDDPEGRPCLSDLEGVPRGIRLFHVGRLDTETSGLILLTNDGEFANRMTHPSYKVLKTYLADVEGRVDDKVIHRLSKGLTLEDGPVKPDVVRLVQAGEEHSLVEVSLHEGRNRIVRRIMDSVAHPVRRLSRTAIGPVRLKRLGRGDMRELTHEELGQLLDLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN80</accession>
    <name>W4TN80_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69868">
        <property type="protein sequence ID" value="GAE69868"/>
        <property type="gene ID" value="JCM18909_3131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10847" checksum="E565B64C4D50D387" modified="2014-03-19" version="1">MSLTVPVEDFCDHLSALRRSPNTIRGYRADLIDLMSHAHSHGDDILGKIGTSQVRAWLADTRVLAPRPLPCSAAGRLHEYFSAGRPTKGSFPPIRRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL5</accession>
    <name>W4TNL5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69983">
        <property type="protein sequence ID" value="GAE69983"/>
        <property type="gene ID" value="JCM18909_3259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="1">
        <location>
            <begin position="99"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="24246" checksum="D55C96F7B5EB97E2" modified="2014-03-19" version="1">MTHMHVAGSVHADVAAAGPQWLTLPDDVNALDPALWSASADRDDDGIVEVAGVTITELLSQYGSPLYVLDESDFRQRARTFRDAFFRVGRLLRRESFFLTRTIASWIDQEGLFLDTCTGGELITALQGGMDPARIGLHGNNKSIDELKLALSVGVGRIIVDSLDEIMRIEQLCRENGWHARVMVRVTAGVEAHTHEYIATAHEDQKFGFSITHGAAMVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX0</accession>
    <name>W4TNX0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Riboflavin transporter PnuX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70237">
        <property type="protein sequence ID" value="GAE70237"/>
        <property type="gene ID" value="JCM18909_3535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006419">
        <property type="entry name" value="NMN_transpt_PnuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04973">
        <property type="entry name" value="NMN_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22912" checksum="53F668E7C2C7F3EE" modified="2014-03-19" version="1">MSDVLASLLNAQLDVGLGKPILWREVIGNLFGLASALGGARRRLWAWPVGIIGNVILFTVFLGGVFHTPQDLNLWGQAGRQIFFFLATSAYGWVVWAATRHNNGASQVAVHPRWATRRERMWALTATVIMLVVFTFALKALGPGVRCRIRGFLLDRSLRPGGWRAAGMSSGLCGLRSMSLASRYWPRPSTTRALSCTFSMELSAYTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP04</accession>
    <name>W4TP04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70436">
        <property type="protein sequence ID" value="GAE70436"/>
        <property type="gene ID" value="JCM18909_3754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17959" checksum="D69CE01DA2E27BB7" modified="2014-03-19" version="1">MLADAGYANGLTLRLRTAALPYATAASRVVASELAQVGINVVTDELEFPARWLDVVYTHADYDLTIVAHVEARDIVNWANPDYYWRYHNKEFNRLIESARTGPADRTNETMMQASRILATDAAGGFLFLMPKITISKSGITGLQRNSTSMSFDLTKVRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP15</accession>
    <name>W4TP15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70451">
        <property type="protein sequence ID" value="GAE70451"/>
        <property type="gene ID" value="JCM18909_3777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="147" mass="15464" checksum="A28CD9C4484B0600" modified="2014-03-19" version="1">MTMTPPIEPGTADQRIPSLTVPEPLETTPGRPATAAILSMTLRASAAGHSTWRLPVVAFGVIATIILDVTGGAVMMWHLPGDNSGFYKLTSTIAVTLLVLPLMTLAASAARLSARRRDDRLSSLRLVGASSHLLRVLTLAEAGLQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP47</accession>
    <name>W4TP47_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70307">
        <property type="protein sequence ID" value="GAE70307"/>
        <property type="gene ID" value="JCM18909_3618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="10011" checksum="53DB439B374DA900" modified="2014-03-19" version="1">MQKKRFLNLPYAMWTSGPLNIDAAEHLRVSLEKWGLEPKSSIKPQLTIPASVPGHELRNHRHGNLLMLAWRLSAKAWTKAYRRRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP56</accession>
    <name>W4TP56_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription termination factor Rho</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69974">
        <property type="protein sequence ID" value="GAE69974"/>
        <property type="gene ID" value="JCM18909_3250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="3">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8812" checksum="62E00901A923179D" modified="2014-03-19" version="1">MREDDVLVPCSGILDIRDQYAFVRTSGYLPGANDAYVSMAIVRRHRLRKGDVIVGQMRAHREGERREKVRAAGQNRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPF1</accession>
    <name>W4TPF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70288">
        <property type="protein sequence ID" value="GAE70288"/>
        <property type="gene ID" value="JCM18909_3596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9187" checksum="1F160068AA3B34D8" modified="2014-03-19" version="1">MTVLAAQLVSTGLANFLCCLVLAVFGVVAWISIRRNIRGIDFDEVPCGPASRRVTEKTRIAASEPQPTGLRPDQVGQWSRMGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPF7</accession>
    <name>W4TPF7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine esterase cutinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70089">
        <property type="protein sequence ID" value="GAE70089"/>
        <property type="gene ID" value="JCM18909_3379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9444" checksum="4D66510146A412D9" modified="2014-03-19" version="1">MVLAGFFSQGSQAITQALAQTDTPQRLAGAILVGNPDHYPGQNVQEVSGDADQSAIGMAAILYYLRERANATPGANRDARCGPSSKPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPG5</accession>
    <name>W4TPG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxy-2-oxoglutarate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70099">
        <property type="protein sequence ID" value="GAE70099"/>
        <property type="gene ID" value="JCM18909_3389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="4092" checksum="9DB930903A1BA582" modified="2014-03-19" version="1">MLAVCLDDVLVGDACEDGIVSALRERCRSVLQVVADADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ03</accession>
    <name>W4TQ03_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe uptake system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70309">
        <property type="protein sequence ID" value="GAE70309"/>
        <property type="gene ID" value="JCM18909_3621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6833" checksum="85D722189E54C496" modified="2014-03-19" version="1">MAASHFDRVVVLADGGVLATGPAEEALSPSNVATAFHVIAHHVTTPEGSRELVCTAALPEPSRKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ08</accession>
    <name>W4TQ08_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70314">
        <property type="protein sequence ID" value="GAE70314"/>
        <property type="gene ID" value="JCM18909_3628"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="15671" checksum="5DA389C781B2BFDA" modified="2014-03-19" version="1">MSGLRLQGRKVLVVGAGHVAERRVVRLLEAGADVHVVAPNSGIQLTRMSRKGLVNLERRAFQIEDLDGVWFVQALTNDPEVNALVAEEADRRGIFCVRGDNSRKGSAFTPATQQAGGMTVSVVGDRTPRRSARLRDEVLRALQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ61</accession>
    <name>W4TQ61_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70523">
        <property type="protein sequence ID" value="GAE70523"/>
        <property type="gene ID" value="JCM18909_3856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7496" checksum="DAB302ED7708971E" modified="2014-03-19" version="1">MSFFSLLKEKHITHIELVPTVFRELIHEIGPSVSFSGLEYVLVTGEELPLRLAKDWAEKNSRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQN3</accession>
    <name>W4TQN3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70539">
        <property type="protein sequence ID" value="GAE70539"/>
        <property type="gene ID" value="JCM18909_3878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9725" checksum="22472EF0B460CE53" modified="2014-03-19" version="1">MSDVMTTSRPDLDVTPRVGFVVSKAVGNAVTRNRVKRRLRHLCRPLVDELEDGTVVVVRALPAAVTQPDRVARDLDGAWHQALRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQY3</accession>
    <name>W4TQY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maltose/maltodextrin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70654">
        <property type="protein sequence ID" value="GAE70654"/>
        <property type="gene ID" value="JCM18909_4022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="200" mass="22010" checksum="F389751FE65A3B42" modified="2014-03-19" version="1">MTVDSPESIKGIQTAVDAFKSKLIPTAALEWKEEDSRNGFESGKVLFLRNWPYQYGNDLKELGPDKFGLAPLPSIDGKAYTPTLGGHNCAITTNCKNKATALKFVKWWTSKESEQYNLEKQSNAPIYGELYTKDENVKKLPYLPTLKASLDAAKGRPHAVAYGDVTAAIQDAIYPALQGKTDAENAAKQLAEKLKSIIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR35</accession>
    <name>W4TR35_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase/helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000075">
        <property type="protein sequence ID" value="GAE70709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70709">
        <property type="protein sequence ID" value="GAE70709"/>
        <property type="gene ID" value="JCM18909_4092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9024" checksum="92F275F2E53254FB" modified="2014-03-19" version="1">MTPFTLCAATSSGNPHNNHYPNHHHITDQTSLEQVAWLDHVAATYTGDRRSSPSFISSDCVVMDIDNDHTRQPRRVDHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE87</accession>
    <name>W4TE87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67280">
        <property type="protein sequence ID" value="GAE67280"/>
        <property type="gene ID" value="JCM18909_326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="276" mass="28560" checksum="015562334B273E41" modified="2014-03-19" version="1">MTAICGIWKTIDPTVANDGWFLVLVGLGGIVIASLNFIVGHNTAQECGGSPVLGLIAGGVPYMPALAGTAATDKMAAIPLTIPIFGELQPGLGGVIGVMITAWLFTVIERRLRKVVPAAIELFFLVPAVTLLLGAAASIFVIMPLSSLLMKGLTWLLVDFALAKGGIIGGFILATFFLPMVMLGIHQGLTPIHAQLIANHGFTELLPILAMAGAAQVGMAIAVLMKTRNPKLRSVIKSTLPIGILGVGEPLIYGVSLPLLYPFLTACLGGGFGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE92</accession>
    <name>W4TE92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67285">
        <property type="protein sequence ID" value="GAE67285"/>
        <property type="gene ID" value="JCM18909_331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="340" mass="39376" checksum="2C6F3B89236C1278" modified="2014-03-19" version="1">MKRILWGGATAASQYEGGFYDGKGMDTQDCRRWIPRLSNDTIQTRLLTEADVRNAKNSRSDDCQFPFRMGSRGYEYWESDLRYITSLGLDVYRLSISWARLFPTGFEDQPNPEGVMYYDRVIRTLAHTGIKVFITINHYAMPIAIVDKYGGWRHRHVIDLYLKMAKFVVDRWQEDVDYWLPINEINSGYFSPYNGLGIIGSIDHSYDYRSVFNGLHYQMIASALITKYGRDIGVRGKFVCMVSCFDYYALHPTPDDNMKLVHDEQINQWWCADVLATGEYGYYTEKFLADHGVVLDVTGKDRGILRSNTCDIVSFSYYSSSICSVDEKNVNKSPETWYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEA9</accession>
    <name>W4TEA9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C4-dicarboxylate transporter DcuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67121">
        <property type="protein sequence ID" value="GAE67121"/>
        <property type="gene ID" value="JCM18909_160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015556">
        <property type="term" value="F:C4-dicarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004668">
        <property type="entry name" value="Anaer_Dcu_memb_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36106">
        <property type="entry name" value="PTHR36106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03605">
        <property type="entry name" value="DcuA_DcuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17179" checksum="0F6332D22B2445EB" modified="2014-03-19" version="1">MIWFHLAVAIIFIIIGSRLGGVGVGLAGGAGCIVLVATGLHTKVAEDIPWTVIGIIMTVICAIAALQLAGGMDYLVHLAGVMLRKHPNQINYLAPLTTFLLSLLCGTGHTAYSVLPVIVEVVKEHKIRPSRPLSIAVVASKSRSHLRRSQRRPWPWSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEE8</accession>
    <name>W4TEE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic amino acid transport protein AroP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67161">
        <property type="protein sequence ID" value="GAE67161"/>
        <property type="gene ID" value="JCM18909_203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="40" mass="4639" checksum="F16C4345A0F6E83E" modified="2014-03-19" version="1">MVVIMAMMPSYRVALVVGPVWLALLWVGYDVSRLVRRRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEF2</accession>
    <name>W4TEF2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67345">
        <property type="protein sequence ID" value="GAE67345"/>
        <property type="gene ID" value="JCM18909_393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022595">
        <property type="entry name" value="Enc34_ssDNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10991">
        <property type="entry name" value="DUF2815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19384" checksum="659F67595971CEBB" modified="2014-03-19" version="1">MTNPTRIVTGEVRLSYAHVWEPNSIQGGKPKYSTSLIIPKTDTATIAAIEKAVDAAIEAGIGKFGGKRPNKAALKLPLHDGDIERDDETYTNAYFVNANSLTAPQIVDQNVAPILDRAEVYSGCYARVSLSFYAFNTNGNRGIACGLGNIQKTRDGESLGDGRVSAESDFGAVTPVDDFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEW9</accession>
    <name>W4TEW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA double-strand break repair Rad50 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67336">
        <property type="protein sequence ID" value="GAE67336"/>
        <property type="gene ID" value="JCM18909_383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="340" mass="38307" checksum="36DAD44406F9D61B" modified="2014-03-19" version="1">MLTRLWSPAFKKNGNLRPVIDLHAGLNIVEGEDETQNLIGKSTLLQIIDFVYAGSDFLKTDAVLLPQAVGHHTIYFTLHLAGKDYHFGRATDRHGFVTRYQDPLWKHTEEELGIDDYQSFLLDQYALKQTGGTWRELVGRFSRVDERDIVLLDRPLAAAAGAKVTDGAKALLELFGAYDEIEHIQSRYDQVSKEVSTLNAMAKGKYSNYIKLTTKKQRNTAQRELLEARSEAKQLRTHADIDLFQAEQKKHDKNRHSNAHTCARWFKNSMQSTVAWRLWRPRFLARPVSPPATLKSSTSSFPTPIVSPSRRSSTTITSSPGSLKNNVSKSSVTTVLNPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF02</accession>
    <name>W4TF02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein YceG like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67366">
        <property type="protein sequence ID" value="GAE67366"/>
        <property type="gene ID" value="JCM18909_416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20541" checksum="D1598E8551B6D131" modified="2014-03-19" version="1">MSGPFNEHDDPKAEFWYKLRSAVAVILSLAVLVGGCVFVGVKVYDGYISYKSADDYLGDGEKDVLVRVPAGASVSEVGSILLDNDVVKSTKAYNKALRDSESDVTIQAGQYKLKTHMNAAKAVSILDNPDNIQRTRVTLPEGLTTEQQFGIMAKGTTMPVDSFQNAYKQTAKLGLPVWAKGRPEGFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFD2</accession>
    <name>W4TFD2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67237">
        <property type="protein sequence ID" value="GAE67237"/>
        <property type="gene ID" value="JCM18909_282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="172"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="718" mass="80504" checksum="9813ACF924C0D824" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFK4</accession>
    <name>W4TFK4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67218">
        <property type="protein sequence ID" value="GAE67218"/>
        <property type="gene ID" value="JCM18909_263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6050" checksum="09B5336C76B067F2" modified="2014-03-19" version="1">MPAEECVVVEDAVSGVRAGAAGGFGMVLGVNRGVGADRLREAGADRVVDDLDEMVEEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFL8</accession>
    <name>W4TFL8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67233">
        <property type="protein sequence ID" value="GAE67233"/>
        <property type="gene ID" value="JCM18909_278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="151" mass="17306" checksum="83B820C3FC849BDD" modified="2014-03-19" version="1">MYSGFEICEHEPLPGREEYAHSEKYEYRPRDYDSEPNITLLVTRLNEIRRAHPALQQLRDTTIHHAPHDNVFVFSKKAGDDVVIVVTSLDPVWGVESQIMLDMAALGFDNDNTFTVHDELTGADFTWGQQAFVRLYPAQPAHILHVRKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT5</accession>
    <name>W4TFT5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 60 family chaperone GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67641">
        <property type="protein sequence ID" value="GAE67641"/>
        <property type="gene ID" value="JCM18909_714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11518" checksum="A25008A0DC7E55F1" modified="2014-03-19" version="1">MLDGDLHLEGDEKAGVQIVAKAVREPLRWIAENGGESGYVIVSKVAEMEPGHGYNGKTGQYVDLIADGVIDPLKVTRSALANAASIASLLLTTETLVVDKPEEDNEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV4</accession>
    <name>W4TFV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cardiolipin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67661">
        <property type="protein sequence ID" value="GAE67661"/>
        <property type="gene ID" value="JCM18909_736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="252" mass="27320" checksum="A08A291B57325FD3" modified="2014-03-19" version="1">MVAAQMATMAGLVTYNGIKRRGRRPYRFPTAPAEPLKVSGHQVEIFTFGRDLYAAMISDIESAQHTVYLETFIWKKNDEVGRHFRQALVEAAARGVKVYAMWDTFANLVVDPRFFRQLEGVQVRAQPLVTPSWIPTLRNLGRDHRKLLIVDSKVAYIGGTTSAPSTPTAGVMPTLVLPGLPSGSSKTSLLTCGINAPREPSSPGATSPYYPLPASAIGIPLSPCTATPPGWRSIPSGICTWRPSIARVSESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX8</accession>
    <name>W4TFX8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67412">
        <property type="protein sequence ID" value="GAE67412"/>
        <property type="gene ID" value="JCM18909_470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12666" checksum="7983347E9F366C19" modified="2014-03-19" version="1">MTPVLTSHSPAAHEVIASPLLTAEPLTRRSIMALQEIEFTSHNGRDAIQAWAYEPVGTPTAVVQIIHGLGEHSRRYLHMISALLDAGFVVIADDHAGHGRTAMQSGVWLTQAITPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG36</accession>
    <name>W4TG36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67487">
        <property type="protein sequence ID" value="GAE67487"/>
        <property type="gene ID" value="JCM18909_549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849064" evidence="7">
        <location>
            <begin position="44"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="278" mass="29173" checksum="82EE56247989EEF9" modified="2014-03-19" version="1">MTNTVVTRNSVPRGVVVLFAITAVAITVTLALGSTVCATDASASCPNWPGCYVGRLTPLDATQPWVEFIHRVISASVGLFALASVIVGVVYRHADKLLAALPIVALLGALTSGVFGMMTIKWGINSVEASFDLLAAIISMGAMWRAYFVACKPRSSWRWNGRTKLGIGAVAFLVIGHFFAVQVAGSGSLTRCMGWAMFVRGAGDGPFAGWIAQQAIMGIGMLLAIAFLVARWGRRNGWDILCAVLIVIELIAGVLIAVNGSSHGLGTCTPSLRCSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG48</accession>
    <name>W4TG48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67920">
        <property type="protein sequence ID" value="GAE67920"/>
        <property type="gene ID" value="JCM18909_1018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="560" mass="62384" checksum="67EC5F15A3F1DBE7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG0</accession>
    <name>W4TGG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67498">
        <property type="protein sequence ID" value="GAE67498"/>
        <property type="gene ID" value="JCM18909_561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="102"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="289" mass="31216" checksum="42521DE5280985D4" modified="2014-03-19" version="1">MVSTALLTALSVAFAGPIGFVGLTVPHIVRFWTGSRHARLLPISALAGALLMVWSDTAARCLRLDTEIPVGVITAIVGPGASRAFASTGLEIMTTVTMSAVLRAEVLGWSVDGKTILSGVSVDVRPQMMTMIIGLNGSGKTTLLHLLAGLRKPGMGRVWLGKRDLARIGAKERSRMMALLEQNPSAHVELTVRDVVQLGRIPHLGRWRMGNLSRRQGHDDDVVEKAMATTGVSELTDRAWSSLSGGESQRVQLARAWHRSPRSYSLTSRQITLTYHTRSTSWSGSEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM0</accession>
    <name>W4TGM0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">JCM18909_760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67682">
        <property type="protein sequence ID" value="GAE67682"/>
        <property type="gene ID" value="JCM18909_760"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="166" mass="16862" checksum="7780C398708736F0" modified="2014-03-19" version="1">MSSRTALGLSAPDLSGLDGSGLRVAVIAAQWHGTVMTGLLDGALRGLVDSGVRDPAVIRVPGSFELPVACASLADHFDVLVALGVVIRGGTPHFDYVCDAATRGITDVAVRTKTPIGFGILTCDDEAQALDRAGLEGSHEDKGYEAAQAAIATFTALSTALASGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM2</accession>
    <name>W4TGM2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67568">
        <property type="protein sequence ID" value="GAE67568"/>
        <property type="gene ID" value="JCM18909_638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="5401" checksum="8DD37CAB3701DA28" modified="2014-03-19" version="1">MWEHAYYLQYQNVKADYVTAWWNVVNWTDAEERFVKARSITGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU1</accession>
    <name>W4TGU1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67752">
        <property type="protein sequence ID" value="GAE67752"/>
        <property type="gene ID" value="JCM18909_833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="2">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12187" checksum="163C5FCC570ABB5A" modified="2014-03-19" version="1">MGVSRVSGSFGTSRSPEQDNSCHVFCEDRGHEVLELLSILLLLQTHERMTSQELTRRFEVSPRTILRDVEALPAAGVPIHTVARSCWTSLVSIRESFSCSLSRGWTRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGV4</accession>
    <name>W4TGV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67996">
        <property type="protein sequence ID" value="GAE67996"/>
        <property type="gene ID" value="JCM18909_1101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12158" checksum="E70F79180228740D" modified="2014-03-19" version="1">MGPGFAVAPVSGDFTSPIDGIVMLVAPTLHAVGLRADNGAEVLVHVGVDTVELKGEGFTAHVNEGDRVRTGDLLLSVDLDSIRPRVPSLISPVVVTNAAGFTISERSNDPASVLSVTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW1</accession>
    <name>W4TGW1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic hydroperoxide resistance transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67384">
        <property type="protein sequence ID" value="GAE67384"/>
        <property type="gene ID" value="JCM18909_440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="11113" checksum="31A265A6DF373527" modified="2014-03-19" version="1">MLVLWHAEGPVGVNDIGTRLHLDSGTLTPLLRRLEDAGFITRAWSSDDERRRIISLTEGGRSLRHQAAGLPERMLALYPAPPQELAQVKAFLDDLATQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG2</accession>
    <name>W4THG2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67594">
        <property type="protein sequence ID" value="GAE67594"/>
        <property type="gene ID" value="JCM18909_666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="297" mass="32486" checksum="95963118CBF2CBFA" modified="2014-03-19" version="1">MANQDLTAELALDLSVAAAHVLGEAGAFGHRQPTALVARDPRASGEFLEAAVCAGLASAGVDVLRVGVIPTPAAAYLVNEYRTDLGVMLSASHNPMPDNGIKFFSRGGVKLPDDLEDAIEQRMGEPWARPIGDKVGRIRYTPQAVDTYVDHLVRSLRQQDTLKGMKIVLDTANGASFHTATAAFTTQGAEVIAIHDQPMASTSMSGAVPPTRRSCRPRLLRLGLTWDWPLTVTLIGAWLSTTKAISSMGITSSRFSRWLCRRTTVWLQHRCRDDHEQPWPHHRNARARYSRRSDQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI6</accession>
    <name>W4THI6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68256">
        <property type="protein sequence ID" value="GAE68256"/>
        <property type="gene ID" value="JCM18909_1380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10542" checksum="012B7E586F7BA5AB" modified="2014-03-19" version="1">MASRSTVLVAKDISKSYGDRIIIDHLSLTVHEGEAVALTGRNGAGKSTVLRMLVGADRPSSGTIEVLGKKKVSETNPEFRRNVATVIDDLDFFPDLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP6</accession>
    <name>W4THP6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67938">
        <property type="protein sequence ID" value="GAE67938"/>
        <property type="gene ID" value="JCM18909_1039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7075" checksum="4BD20A33893F7CB9" modified="2014-03-19" version="1">MRPVLQIGTTHGDETLHCSGTAAESGAVWIMPVRVGVPFRALVATVSGIGLLGLALLIHSGRLLDREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT1</accession>
    <name>W4THT1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68346">
        <property type="protein sequence ID" value="GAE68346"/>
        <property type="gene ID" value="JCM18909_1475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14578" checksum="6C8639311C9F8AB1" modified="2014-03-19" version="1">MMFLLGNANYAIIVLIGCLRVAKGQMPLGNVQAFIQYSRMFTQPITQIASMANLLQSGVASAERVFQVLDADELSTDAHGSSQPRRDESSSTTFASPTTRTNLSSPTYPWSQNQDRRLRSSDPPEPARRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ2</accession>
    <name>W4THZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GtrA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68142">
        <property type="protein sequence ID" value="GAE68142"/>
        <property type="gene ID" value="JCM18909_1260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9756" checksum="CAC789DF4340B9C8" modified="2014-03-19" version="1">MFIKIFFTNPTSPIYLPEPWFNEGRGIQSREYWSQIFAIVVTMPINFVVNKLWTFRVVKHSGELPMIASAVAPESYDDGDAAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI32</accession>
    <name>W4TI32_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argB</name>
        <name evidence="9" type="ORF">JCM18909_1546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68411">
        <property type="protein sequence ID" value="GAE68411"/>
        <property type="gene ID" value="JCM18909_1546"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="310" mass="32913" checksum="06E86CF004ACD70F" modified="2014-03-19" version="1">MTLALDIPLNDSQFSAQRKSEVLVEALPWIRRFQGRTVVVKYGGNAMVDPGLQQAFADDIVFMASVGIRPIIVHGGGPQINAMLAESATPVEFRNGLRVTSPEVMEVVRMVLVGQVGRQLVNRINAYAPLAAGMSGEDSGLLSARKSRVIVDGEQIDMGLVGDIVDVNIDLVISMLDRGQIPVIAPVSPEVDAAGRPTGQVLNVNADTAATAIAQALRAEKLVMLTNVAGIYGTWPDPHTLISEVSASDLRAMIPRLGEGMRPKAQALLDAIDGGVSSAAIVDGRIEHALLLEIFTTRGVGTMARSDDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI60</accession>
    <name>W4TI60_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68441">
        <property type="protein sequence ID" value="GAE68441"/>
        <property type="gene ID" value="JCM18909_1579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="165" mass="18012" checksum="6709DABBF5B3E856" modified="2014-03-19" version="1">MSTSTIVFIPTSAERAHQLVAAPGKQVTAFTVTEELQSILDVTDPEETEHAAMVIGSVWGLTHTGRRLVLVAHVPPEQITDHEEVDNGGVTLTYLEPSQITAWFADDDDAHSREAAEAVKGMTIDDAWNDVTIQTLIGEHELSWHDVTEELPAVSTDPEGFRGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI79</accession>
    <name>W4TI79_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68665">
        <property type="protein sequence ID" value="GAE68665"/>
        <property type="gene ID" value="JCM18909_1816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4593" checksum="C45F96208B8317D4" modified="2014-03-19" version="1">MAPCLPSVFGVDFMDGDDLHPQANIDKMASGYPLNDEDRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH0</accession>
    <name>W4TIH0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68233">
        <property type="protein sequence ID" value="GAE68233"/>
        <property type="gene ID" value="JCM18909_1356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="59"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="283" mass="31019" checksum="700234519B35BF36" modified="2014-03-19" version="1">MLLFVFIFVLPIAYTIMQSFLKPGQKKLLYAPSGPTAPQFAGISQYTAAFQDSHFLLSIGRVLLIGMVQVPLMLLFSVCLALLLDARRVKARQGFQLAYFLPYAVPGAISALMWTFLLQPQLSPFTSLFQKMGLNLNLLAPSVVPISVGNMITWGFAGYNMVVIYSALKTLPNEILEAAHVDGASSWRTAWQIKVPMVRPAVIMTAVFSIIGTIQLYNEPAILRNSAPRIDPDFSPIMAVYNLVTTGDYFGAAARSVILAVITLVASFGFLKLQSRRGGAFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK3</accession>
    <name>W4TIK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport ATP-binding protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68611">
        <property type="protein sequence ID" value="GAE68611"/>
        <property type="gene ID" value="JCM18909_1758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6802" checksum="D641203601F16858" modified="2014-03-19" version="1">MILQRPRVLILDEFTASIDPDLAAEIRVNLARCLLGSLWWRLVMNAIVVVRLLCWIAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL1</accession>
    <name>W4TIL1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68372">
        <property type="protein sequence ID" value="GAE68372"/>
        <property type="gene ID" value="JCM18909_1502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="297" mass="32811" checksum="4729B36D29BC6E8F" modified="2014-03-19" version="1">MRTLMSPSRGRINTMHLDLGLTKTINRATHVTRGFRRIVMVTAAGEGRPDRLVTDLTNEFSRREIDVSQLPIEGSEDTASSMPAPAHKVLAKWSRHRQGTARHELGESLDHQCALIVTDPRRLDEIIGFQAQSDRPVVVLLATDPDDAPDKLPEIVDVVVTPNPQTDPWEHLGVPVHSIGVPATGGSPAPGDRPNRIALLGPCTDEQLADALLAFDHACHVVPGWSLEICLDDESRARSAVAAPRRRYSPSWIRKHGYEPERVGPSHDPQGGSGLPNPRRRWRRPARSRLRRHPCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIT5</accession>
    <name>W4TIT5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68338">
        <property type="protein sequence ID" value="GAE68338"/>
        <property type="gene ID" value="JCM18909_1467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9386" checksum="529B0E01EF7D5AE1" modified="2014-03-19" version="1">MHRSGYRLMIAACMFAMYGNLGYRPSGIAFDMWIASATGRTLKIMTISACVFVPIVLAYQVWSYWVFRKRLTREAIPDTAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX6</accession>
    <name>W4TIX6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-ornithine 4,5-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68477">
        <property type="protein sequence ID" value="GAE68477"/>
        <property type="gene ID" value="JCM18909_1618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037086">
        <property type="entry name" value="Lys-AminoMut_asu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09043">
        <property type="entry name" value="Lys-AminoMut_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lys-AminoMut_A" evidence="2">
        <location>
            <begin position="101"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="250" mass="28174" checksum="61471400C3323E22" modified="2014-03-19" version="1">MTIQDTCLHHKHAREREQLGPNNKSAVTPSEPVEPRTEQEPPGPNTKLNVEEILTDLEHYHPRRKGWSWRNVPEEGIDMGDFHYRNMSTPLKQSMPLPAAEYFENIDPQPAPVVTSEIASGHFEDDLRRMRMAAWHGADHIMVIRIMVIRTTGQSHIDGLLEGTPEGIGGVPITRKQLRASRKACDLIEDEVGRPINFHSYVSGVAGPEVAVLFAEEGVNGAHQDPQYNLLYRNINAYRSYVDAGEAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ37</accession>
    <name>W4TJ37_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6286 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68955">
        <property type="protein sequence ID" value="GAE68955"/>
        <property type="gene ID" value="JCM18909_2132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046253">
        <property type="entry name" value="DUF6286"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19803">
        <property type="entry name" value="DUF6286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6286" evidence="2">
        <location>
            <begin position="77"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20320" checksum="C5314E28DA73B2D0" modified="2014-03-19" version="1">MSKQYVSPPLIRRPSRTLPVTILAVVLLAAGVVAIIAAIQRLQHGSLPQWLAWGRGHMTTASWLNDTALTVAIVIGVVALLFLIWAFKPGRTSGVFLQPSEGVPDNREIVMDNSDLTGWLSRWLDEEDGVASSVVKRRGKTLKVHAETDVKDPEVMREQLTTRIAARVDSLGLEQPLKVEVRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ54</accession>
    <name>W4TJ54_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein YcaR in KDO2-Lipid A biosynthesis cluster</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68821">
        <property type="protein sequence ID" value="GAE68821"/>
        <property type="gene ID" value="JCM18909_1985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9992" checksum="8121D806C233F1F7" modified="2014-03-19" version="1">MPDLPLAPEALDLSPAFLEVAACPVCHSRFALDFDSGELVCSSPSCGLAFLVRDGVPDLRLDAARKRETGQGVNAEDTEAFEPTHRHEMRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ84</accession>
    <name>W4TJ84_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein TerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68602">
        <property type="protein sequence ID" value="GAE68602"/>
        <property type="gene ID" value="JCM18909_1749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="13841" checksum="59D6D502BAB6FD23" modified="2014-03-19" version="1">MFMVCVALGATDLLFALDSIPASYGLTSEGYLILTANVFALMGLRQLYFLIGSLLKRLVYLSLGLAVILGFIALKLIGHAMHHYGLDQAWFGFSSEVSIGVSLGVIVVTLALTTVASLIKSRKDDATADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ96</accession>
    <name>W4TJ96_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69020">
        <property type="protein sequence ID" value="GAE69020"/>
        <property type="gene ID" value="JCM18909_2201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18494" checksum="454D384E5D561193" modified="2014-03-19" version="1">MLGDTDASTMNALGVLDHVVARAGRIKEGAYDAKTLAKLKAIPTIASQELNTGGVKVSTETILDQHADLVIGYDTGVDRDALRKSGVKMYSTDAMCTDKKPPAPATFSQVKDEVTKVGQIFLTFRIRPNRSTKSSTPRSPESRSRPLLGPKPMPSPCTSPRVAPSSTPTVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA7</accession>
    <name>W4TJA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NagD-like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68239">
        <property type="protein sequence ID" value="GAE68239"/>
        <property type="gene ID" value="JCM18909_1362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5983" checksum="996694759DAC44CA" modified="2014-03-19" version="1">MIEAASRHKPYIVGKPNPMMFRSALNRIEAHSETTAMIGDRMDTDMVAGMELGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC4</accession>
    <name>W4TJC4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68254">
        <property type="protein sequence ID" value="GAE68254"/>
        <property type="gene ID" value="JCM18909_1378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019993">
        <property type="entry name" value="RecB_nuclease_TM0106_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03491">
        <property type="entry name" value="TIGR03491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="387"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="607" mass="67671" checksum="F556EC5E6540A1B0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ6</accession>
    <name>W4TJJ6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplW</name>
        <name evidence="6" type="ORF">JCM18909_2319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69130">
        <property type="protein sequence ID" value="GAE69130"/>
        <property type="gene ID" value="JCM18909_2319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11311" checksum="5E308F07A7F55C39" modified="2014-03-19" version="1">MSELKIRDPRDIILAPVVSEKSYGLLDQNTYTFVVKPTANKTEIKIAIEQIFGVKVTSVNTMNRKGKVRRTRTGVGKRPDTKRAIVTVAEGDHIDIFTGPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM2</accession>
    <name>W4TJM2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68344">
        <property type="protein sequence ID" value="GAE68344"/>
        <property type="gene ID" value="JCM18909_1473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="12167" checksum="C0A9F0DB378CC54E" modified="2014-03-19" version="1">MFRWVKKQLITIARAFLAAPDLLILDEATSSVDTRTEMLVQEAMANLRKGRTSFVIAHRLSTIRDADLILVMEHGDIVEQGGHSELLEHQSHYYELYQAQFAAASHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJN4</accession>
    <name>W4TJN4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68986">
        <property type="protein sequence ID" value="GAE68986"/>
        <property type="gene ID" value="JCM18909_2165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10585" checksum="D753F1B559C54987" modified="2014-03-19" version="1">MIEKKILVCCGTGTATSVQVANKLQRLLRERGINARMEHCRVAEVPRVAERFSPDAIVSTTAVKQPTENVKMFRGVAFLTGVDEGQLADEIANALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ3</accession>
    <name>W4TJQ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69185">
        <property type="protein sequence ID" value="GAE69185"/>
        <property type="gene ID" value="JCM18909_2376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10449" checksum="99851620B85419C2" modified="2014-03-19" version="1">MSATDTEVRLDKVLVIIPTYNEVENVETIVARTRRANPNVDVLVADDNSPDGTGEIADRIASADDHVHVMHRKGKEGLGAAYLAGFHWGLDHAMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR9</accession>
    <name>W4TJR9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">(d)CMP kinase</fullName>
            <ecNumber evidence="4">2.7.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69200">
        <property type="protein sequence ID" value="GAE69200"/>
        <property type="gene ID" value="JCM18909_2393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="10">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="23062" checksum="228AB9632C29F6D8" modified="2014-03-19" version="1">MSTSPLVIAIDGPSGSGKSSTSRGVANRLGLARLDTGSMYRAVACRVAHLGIDPTTNPRDAIKVAQSCHLEIDTSAIDDRVVIDGEDVTKEIRDPQTSAKVSAVATIQPVRDALTARMRQVAADRGRIVMEGRDITTVVCPDAQVRVLLVADPAIRVARRQAELGEKKSIWPRSLIRSCVVTGTIRLCRPLRSQLKGSLWSTPPTSIWIKSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW1</accession>
    <name>W4TJW1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription-repair coupling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69081">
        <property type="protein sequence ID" value="GAE69081"/>
        <property type="gene ID" value="JCM18909_2265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="2">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18093" checksum="6E7F6002916790E5" modified="2014-03-19" version="1">MAVEPWHGDVEAAVKGLTTCLDDGWTVLLCAEGEGMAKRMSELLGEHNVAARLVDDVDPDATEPCVQVIRLHQRHGFAAESVKLLVASTGDLAESQDPGGTGERRMPRRRRNQIQPLELKPGDLIVHEQHGVGRYVEMVQRTVGGATREYLVIEYAPSKKRSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY3</accession>
    <name>W4TJY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68743">
        <property type="protein sequence ID" value="GAE68743"/>
        <property type="gene ID" value="JCM18909_1898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19927" checksum="817137E0057BEBC9" modified="2014-03-19" version="1">MMIMSQGDSGRSINEGATKTCDDVRPQMEKSAATAWLSIEQQRVWRAWLLGSAHITSCLSEELRRHGLELCEYEILASLSEADDYAVRMSVLATKVHQSRSRLTHAVERLEARGLVTREPDVRDRRGVVARLSPAGMDLLRQAAPDYARTVRHVFVDPVGPEDFAAMGRAIRAVLSVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK07</accession>
    <name>W4TK07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal-dependent phosphoesterases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68449">
        <property type="protein sequence ID" value="GAE68449"/>
        <property type="gene ID" value="JCM18909_1587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="242" mass="26075" checksum="A918E93CA00F2621" modified="2014-03-19" version="1">MMKAAGSGLDVVALTDHDTFDGLEEAQAAGQRFGVRLLPGFEMTCHIGSRDVHLLGYGARPDDPVLGRELQATRASRVGRLDAICQRLSDAGMTVTIDDVHRTSGSASSLGRPHVADAMVAKGYVEDRDEAFRDWLSDGKPAYVPRRSVALEEGIDLIHNAGGVAVLAHPWGRGAQQDLTPQVIASLSAYHQLDGIEVEHQDHDQVARRMLFDLGGRLGLVRTGASDYHGSGKKRITSWGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK15</accession>
    <name>W4TK15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68773">
        <property type="protein sequence ID" value="GAE68773"/>
        <property type="gene ID" value="JCM18909_1930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6761" checksum="C4999B4F38014E13" modified="2014-03-19" version="1">MRLDDLDAQVRLTPNHKLAVFIDDVQVGMAPDEASESYRHVVEALHFSHRCLLFRPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK23</accession>
    <name>W4TK23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_2506</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69305">
        <property type="protein sequence ID" value="GAE69305"/>
        <property type="gene ID" value="JCM18909_2506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="13">
        <location>
            <begin position="69"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="14">
        <location>
            <begin position="197"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE69305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="399" mass="41745" checksum="AA17E6D334476BC2" modified="2014-03-19" version="1">MKLLTKLARALVNPEFVEQLRQAPDAQTVVDLIGGVVEPKEEASTSSATALPAPGHAAVTNAASDTPRIVAITACPTGIAHTYMAADYLRAAGKKLGVDVKVEPQGSTATEPLSTGDIEGADAVIFATDVGVKGRERFAGKPVIESGVKRAVDEPEKMVSEAVAASKDPHAHRVPAGHGEQQEPEQAGSHIGWGKRIQQALMTGVSYMIPFVAAGGLLIALGFLFGGYEIAKDGMNIALHNTFSNLPTPTAHALGGSATMTYIGAILFAVGQAAFGFLLPALAGYIGFGLADRPGIAPGFVAGAVAGVTGAGFIGAIIGGLLGGFVAYWFTRLNPPRWLRGLMPVVIIPLVVPGRRWVDVCRTGTSAGSLDERPQRLARRHERRLSRHPRNRPGTHDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK41</accession>
    <name>W4TK41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69320">
        <property type="protein sequence ID" value="GAE69320"/>
        <property type="gene ID" value="JCM18909_2522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="235" mass="24766" checksum="CD4C5B888FC656CC" modified="2014-03-19" version="1">MSSLPSEPTVTQSGSSAIEREATTDSSNQPPRPRDPGQPIDLLGFLKGLGHHWLAGLITFIVVAGLLVGYSLLMAPKNTVGTVAAHAHVMVTLPEPRTEAQATVESATVGQIMSNYVALTTPDPIVNTAVKYLHDGTTADDLKAGASVYWGGGGTVIAVYAMGTNQNQATERANAYARAFAEKANDLVPSSLAGLPRPKLTIVQPAFPSDPNPNAPATNKNSTKLSSRWWEWPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA8</accession>
    <name>W4TKA8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68868">
        <property type="protein sequence ID" value="GAE68868"/>
        <property type="gene ID" value="JCM18909_2038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848794" evidence="1">
        <location>
            <begin position="28"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="8710" checksum="B4AF30BBA5A1EA48" modified="2014-03-19" version="1">MKVRTTMCLASAVMAIGVVSWPVAAHADAGVSGRLCADPTHECTVSVMGGHAREVAYSGVDVTGARGFGCVWRPTMYAPMHTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB3</accession>
    <name>W4TKB3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68589">
        <property type="protein sequence ID" value="GAE68589"/>
        <property type="gene ID" value="JCM18909_1736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVRC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="330" mass="36313" checksum="E2AE0FE8AD39C0F0" modified="2014-03-19" version="1">MSTILSSERGSHVEIRVPRRGDKATLMDTVTRNAQETLAQHKLKRASDLATRTRALEEIQESLGLDRAPLRMESYDISHIQGTNVVGSMVVFEDGMPRKSEYRRFIIKGFEGSDDFAAMHEVLSRRLRRLIEDRDVMASAQTPDGDVGSLIDPTTGAPREFAYAPHLIVVDGGAPQVHAAQQVLEEFGLEDEIALCGLAKRLEEVWLPDEEWPVILPRTSEGLYLLQRLRDEAHRFAITFHRSKRSKAMVESVLDGVPGLGETRRKALVSHFGSVRSLRMATVDDIAEVPGFGPKLAGEVVAALSQDKPAEAINTATGEVVDANGPDAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD0</accession>
    <name>W4TKD0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68609">
        <property type="protein sequence ID" value="GAE68609"/>
        <property type="gene ID" value="JCM18909_1756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14179" checksum="160DDF2A8613E438" modified="2014-03-19" version="1">MQARRRLEAIIHPLVEEAAHRVDEEARAADGLVVVVHDIPLLVETGRADEFDVVMVTDVDPAEQVRRVVERDGCSQADAWARIRAQASREERLAVADVIIDTSVPLEDLPEQIDRVWSRIVEALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE0</accession>
    <name>W4TKE0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68898">
        <property type="protein sequence ID" value="GAE68898"/>
        <property type="gene ID" value="JCM18909_2070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9085" checksum="17A390275D03FFAA" modified="2014-03-19" version="1">MHFLGIDYAESDASEAISFAGDAGLTFPHLQDPDSTIQGAWQISGVPVTFIVRDGTIVTRHSGQWRSQRELDSAIDKAIKRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ9</accession>
    <name>W4TKJ9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein JCM18909_2108</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68933">
        <property type="protein sequence ID" value="GAE68933"/>
        <property type="gene ID" value="JCM18909_2108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="10817" checksum="D283F143BE652B40" modified="2014-03-19" version="1">MTTGGFDLGGLDMGALLAQAQSVQNQLEAAQNQLAESNFEGTAGGGLVRATVTGTGELDALTIAPETLEDTDAETLADLVVAAVKDATGQARAMQQSLMPQVPSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL4</accession>
    <name>W4TKL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical radical SAM family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69485">
        <property type="protein sequence ID" value="GAE69485"/>
        <property type="gene ID" value="JCM18909_2704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HemN_C" evidence="1">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8767" checksum="097831CAC8FBCA66" modified="2014-03-19" version="1">MLPVDDYEVLDDVQRHEETVLLRLRLADGLPMADLSEVECMRATEVVKQGLGTMEEGRLVLNLSGRMVADRIITDLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP8</accession>
    <name>W4TKP8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vitamin B12 ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69361">
        <property type="protein sequence ID" value="GAE69361"/>
        <property type="gene ID" value="JCM18909_2569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="264" mass="29837" checksum="683A8D6BCE2C0ED0" modified="2014-03-19" version="1">MAIQKTREALKDHKVADFGVGDGTTEVNTEKLASLRPDLFIVSGHDDPGKFAKVKEMGTPVVAEPDFLENTPLGRAEWIKYDSLFVNAEKVANHKYDEIAKKYHETIQHTATVKTRPSVLYGYQFKGTWYIKSNENYSIQFLRDAGGSYVFSDVHGITSSKLDTETILAKAHDADFWIDGHINEPEKSSIPRIIKADPRMKTLKAVRTGNVWDATLRTDPKHGNDYWQTGIVRPDLVLADLSAILHPELSPHHRFIFYRKATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ6</accession>
    <name>W4TKQ6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Abhydrolase_9_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69112">
        <property type="protein sequence ID" value="GAE69112"/>
        <property type="gene ID" value="JCM18909_2300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027788">
        <property type="entry name" value="Alpha/beta-hydrolase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15420">
        <property type="entry name" value="Abhydrolase_9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="274" mass="29735" checksum="0A0C30F7E4D40553" modified="2014-03-19" version="1">MVAVNVWLSTLFAYGIGGFIGRISRWLAEITRLQVSVSTSAVRGIQRSWYAILALISLGMFIWCTRQQRSVSDAVGLPRKVWFAQTVGVLTGLIFFVTAVLLMRFIAHGIRTLYTGVHRFIAQPVLAVVVVALSVALLLWATNNVIVRTTANGVAHVMAQTNAQTAAGRTPPTSPLRSGSPNSLQPWDGLGREGKDVVTDGPSAAMISDVMGKPAKEPIRYMPGSMPNVITPRRLVACSLSSFAPEHFTVRCSSFRTARVPAGWRNGQCLRSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL82</accession>
    <name>W4TL82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69496">
        <property type="protein sequence ID" value="GAE69496"/>
        <property type="gene ID" value="JCM18909_2717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010147">
        <property type="entry name" value="CRISPR-assoc_prot_CasD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01868">
        <property type="entry name" value="casD_Cas5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17169" checksum="F7C89CCB1E05A473" modified="2014-03-19" version="1">MTVLLLRLAGPLQSWGDSSRFTTRATRREPTKSGVIGLLAAAQGRRRTDSLEDLLTLRFGVRTDQPGSIVRDFQTAMDWAHPKKDGRVKAMPLSNRYYVADAVFVAAVEGDPSLPPGVGRGNQRPGVPALPRTKILSHGRTGVLRRARERAGEDLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD0</accession>
    <name>W4TLD0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69551">
        <property type="protein sequence ID" value="GAE69551"/>
        <property type="gene ID" value="JCM18909_2780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11861" checksum="481F3F09C7C5E4BB" modified="2014-03-19" version="1">MGAKYLDLNVDALAIGGRLDIIGMQGGVKGELNIAKLLNKRALVTATSLRPRPLEEKAKICQRVREVAWPLYTNGSIKPAPVESFPMPEAGKAHERLESGEVLGKVALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD8</accession>
    <name>W4TLD8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">23S rRNA (Guanosine-2'-O-)-methyltransferase RlmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68964">
        <property type="protein sequence ID" value="GAE68964"/>
        <property type="gene ID" value="JCM18909_2142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="11477" checksum="7F172C02A17BD2C1" modified="2014-03-19" version="1">MTAAAWKTSAGAAARIPVAMATNLNQALGKFAAAGWMIVGLAGEADSDFASAPGLDGPLVIVVGSEGDGLARLTRQSCDVLASIPISSDVESLNASVAASIALYEAARMRGSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE2</accession>
    <name>W4TLE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69800">
        <property type="protein sequence ID" value="GAE69800"/>
        <property type="gene ID" value="JCM18909_3055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="67"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="272" mass="29733" checksum="3A3D3E844C4C6C83" modified="2014-03-19" version="1">MHIGAFFRHLFLILGGLISLFPFYWMFVLASRPSSVIYKYPPVLTPGNRLGENVHTITDKVNIWAAMANTALVATTVSVLVLLISSLAAFAFAKFDFPGRNVLFVIVLATFLLPTQLATIPQFVLMSKIGWVGDLKAVIVPSLASSFGVFWLRQYATNAIPKELLEAATLDGCGFWHQYVHVCLPIIRPAMAFLGIFTFIGSWNDFMWPLIVLNDPSKLTLQVALSQLKTAHGTDYGMLMASSLIAVVPLLVVFTIGAKQLIAGISEGAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI6</accession>
    <name>W4TLI6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69019">
        <property type="protein sequence ID" value="GAE69019"/>
        <property type="gene ID" value="JCM18909_2200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="21942" checksum="B2E8AF8B844AFD1E" modified="2014-03-19" version="1">MGVVGPNGAGKSTLLSALYRNVSIASGQVTVSDHDLASMSRREIAREVAVVSQTPDPSLPLTVRDTVALGRLPHRSLMGYGDAADRNIVEEALTRTDLTDLADRLVTQLSGGERQRVLVARAIAQQAGHLLLDEPTNHLDIGHQFALLDLVRTIKQPPSSCYMTSIWLPGYATSWCSSPRSIWSPPAPAKTSCSPICSRRSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLQ9</accession>
    <name>W4TLQ9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69437">
        <property type="protein sequence ID" value="GAE69437"/>
        <property type="gene ID" value="JCM18909_2652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="40"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="268" mass="30608" checksum="76668F0EA30C581A" modified="2014-03-19" version="1">MARITPRPPKRGPLPHPSGARPPALPPELIPQHVAIVMDGNGRWAKQRGLRRTEGHARGEDALFDVIEGAIEMGIPYLSAYAFSTENWKRSPDEVRWLMGFNRDVIHRRRDQLDAMGVRIRWAGRRPKLWKSVIKELESAEKQSTDNTVLTLQFCVNYGGRAEIVDAVRDIARLAAEGKIDPDHITEKTFRTHLDEPEVPDVDLFWRSSGEQRTSNFLLWQSAYAEMVFSDVLWPDVDRRDLWAAVAEYAKRDRRFGGAVPHEVNPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR6</accession>
    <name>W4TLR6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ORF">JCM18909_2318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69129">
        <property type="protein sequence ID" value="GAE69129"/>
        <property type="gene ID" value="JCM18909_2318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="29370" checksum="EB1F582F7F229F62" modified="2014-03-19" version="1">MNTNIPLIHQVVVAQLAAARQGTHATKTRGQVSGGGKKPWRQKGTGRARQGSTRAPQWVGGGTVHGPQPRSYAQRTPKKMVAAALRGALSDMARDNRIFVVTSLVDGDKPSTKQAKAVLSGLAELRKVLVVLDRSDEIDWLSVRNLSEVHVLAADQLNTYDVVNARTIVFSQAGLDAFVGARSANTQALSAEPEVPETNVADQHPYGEDSFRGDNPPAGFDIKGNEDSMKFHEPSSPWYGRTIAEVWFRSAAAAEAAGFVNAVKSDSEKEDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS6</accession>
    <name>W4TLS6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69462">
        <property type="protein sequence ID" value="GAE69462"/>
        <property type="gene ID" value="JCM18909_2679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="133"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="238" mass="26143" checksum="8967BF3E49E1748B" modified="2014-03-19" version="1">MGTRPSEVRRQAATIERQRTQLAEQAVLDERLRIAREMHDSMAHHVSVVGIHAAGARRALDVDPDLAREALAAVESESRETITEMRSLLGSLRAGDEPRARLGLADLDRLCDEPRRASVRLLRVGDDFLVGSQPGHACYRIVQESLNNVEAHSSATEVTVSVRCRDDEVEVEVTDNGRPIRSAPSTGVGIVGMSERVEALGGTIEVGPRKVGGWRVRAVIPMRRGENVRDEDMKEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV3</accession>
    <name>W4TLV3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69398">
        <property type="protein sequence ID" value="GAE69398"/>
        <property type="gene ID" value="JCM18909_2607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6058" checksum="BD2F830BEE7050EF" modified="2014-03-19" version="1">MTSFGWVVAATGTGALPDAIADCVTMGAPMTAMIPAMANALSFVVKVMPCSFACGVDVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX4</accession>
    <name>W4TLX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69970">
        <property type="protein sequence ID" value="GAE69970"/>
        <property type="gene ID" value="JCM18909_3246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6101" checksum="D9348AB13DA8B997" modified="2014-03-19" version="1">MSESAQQAIDEVRRRLREIETQLADSAVLSDPSAMGSSVSAMHAFAMWCQSPTASTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY4</accession>
    <name>W4TLY4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69537">
        <property type="protein sequence ID" value="GAE69537"/>
        <property type="gene ID" value="JCM18909_2763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10630" checksum="FBEC4F405345AE00" modified="2014-03-19" version="1">MGLLSIFAHDLPGGGWVVRNHGIDGAGNGVDTLEHMILLTALSVLAITVPTIVFIFALLSILRSDRLTGTGKVIWIVVCFCFPLVGPIVWFIAGKSTALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ0</accession>
    <name>W4TLZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69990">
        <property type="protein sequence ID" value="GAE69990"/>
        <property type="gene ID" value="JCM18909_3266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11556" checksum="A5C7D162DD93A901" modified="2014-03-19" version="1">MLVAAAGTWISTVVLLIVVIRVIVSGRDIFGAGVGAMLVIYAGLVALVGWLAIKGWSSAQGLLVASGLLHLVVLVSTQRSGGPAWFWGLAIIPATVVVASLAPRPRTWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA6</accession>
    <name>W4TMA6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69667">
        <property type="protein sequence ID" value="GAE69667"/>
        <property type="gene ID" value="JCM18909_2912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024551">
        <property type="entry name" value="AspAT_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12897">
        <property type="entry name" value="Asp_aminotransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="8749" checksum="EAF71708B44E1163" modified="2014-03-19" version="1">MIPVELGEHGPDVDEVAKLAADPSVKGMWVVPMYANPNGAIYDERTVRALVSMLTAQISVSGGITPMPCTTSPTLSTLPAGAPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ7</accession>
    <name>W4TMQ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma-70 factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69996">
        <property type="protein sequence ID" value="GAE69996"/>
        <property type="gene ID" value="JCM18909_3273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="4">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8480" checksum="1150701F05F079D2" modified="2014-03-19" version="1">MDRRVDASGTVDVAEETKTQRAQRFERDALEYLDQLYGAALRMTRNPADAEDVVQEAYAKAFFLVPPVPTWYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR8</accession>
    <name>W4TMR8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PTS system mannitol-specific EIICBA component</fullName>
            <ecNumber evidence="5">2.7.1.197</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">EIICBA-Mtl</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">JCM18909_2693</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:33363"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.1.197"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.197" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69474">
        <property type="protein sequence ID" value="GAE69474"/>
        <property type="gene ID" value="JCM18909_2693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022872">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05567">
        <property type="entry name" value="PTS_IIB_mannitol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029503">
        <property type="entry name" value="PTS_EIIB_mannitol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="14 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="21">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="20">
        <location>
            <begin position="271"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="19">
        <location>
            <begin position="387"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GAE69474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="528" mass="56457" checksum="D66EB07BBBDA6463" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT5</accession>
    <name>W4TMT5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="6" type="ORF">JCM18909_3306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TMT5"/>
    <dbReference type="EnsemblBacteria" id="GAE70026">
        <property type="protein sequence ID" value="GAE70026"/>
        <property type="gene ID" value="JCM18909_3306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6538" checksum="BDD2B4C55040F8FD" modified="2014-03-19" version="1">MAVPKRKKSRSTTRHRRAQWKTTPTQLVEIRVEGKVLRVPRNLVKAYHSGLIDVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU0</accession>
    <name>W4TMU0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70031">
        <property type="protein sequence ID" value="GAE70031"/>
        <property type="gene ID" value="JCM18909_3311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6645" checksum="FA258C1DDB0FA274" modified="2014-03-19" version="1">MTILARSRTIAMGESRRCDRRRLSRQGDTIDRITTGGDVMRTDLLRLVSLSRWHNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW2</accession>
    <name>W4TMW2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69753">
        <property type="protein sequence ID" value="GAE69753"/>
        <property type="gene ID" value="JCM18909_3004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="4939" checksum="52EF9D7D734A3C32" modified="2014-03-19" version="1">MCPASVLQFHPHVLVIADDAAASKLTMAEYFRWTDSQRGDLSGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN94</accession>
    <name>W4TN94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70415">
        <property type="protein sequence ID" value="GAE70415"/>
        <property type="gene ID" value="JCM18909_3733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9329" checksum="BB6EF0074A53C4AE" modified="2014-03-19" version="1">MSDEVSDETPHNEADDEKHVRASRTDGVSGEFGDAAPVALDVPGESESCSADKIGAMSRVVVEVMPKPEILDPQGKAITSVLARLGHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNC9</accession>
    <name>W4TNC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70246">
        <property type="protein sequence ID" value="GAE70246"/>
        <property type="gene ID" value="JCM18909_3545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12759" checksum="9741F639C062589A" modified="2014-03-19" version="1">MFGHHGDRALGVASVNCLVGQPGQFTEQVMATHTAWGKQHLKIEAYHWVLAFGTDELDPGDPEAVSKALELASTMARLAWLTRQTLLVAQNDGESGLLHVHVLVAPSTRSPTGPHAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN2</accession>
    <name>W4TNN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70147">
        <property type="protein sequence ID" value="GAE70147"/>
        <property type="gene ID" value="JCM18909_3443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10525" checksum="E47F677FF1261F90" modified="2014-03-19" version="1">MDTLMRITDHLTTSPGIQLKIDKRWCASVTFVTRSIAHVRIFDAAGPQLDRTWSISVGSDVTPRTGLGPVTSSTIPLPRHGRAILAMSRPSRTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNQ5</accession>
    <name>W4TNQ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70028">
        <property type="protein sequence ID" value="GAE70028"/>
        <property type="gene ID" value="JCM18909_3308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="9922" checksum="B70A2EE0AF67C010" modified="2014-03-19" version="1">MVKALARTGKPVVEMMTGTPYDVAMTHRPHAALAVYSNRKVSMVAAVAVMAGRNPVGRLPVRVPDPNGGTAFPRGFGLSYRATPGPYEGPGAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT3</accession>
    <name>W4TNT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69869">
        <property type="protein sequence ID" value="GAE69869"/>
        <property type="gene ID" value="JCM18909_3132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9835" checksum="CD4383F982F151B3" modified="2014-03-19" version="1">MGERGRRIDQRVVRRVVHTHLRAEPDSPDLGPHGLRHAMATHLVEGGADLRTVQDMLGHESLATTQIYTHVSTERLRTAFRQAHPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY8</accession>
    <name>W4TNY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70416">
        <property type="protein sequence ID" value="GAE70416"/>
        <property type="gene ID" value="JCM18909_3734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="4979" checksum="BE89D87E7D96739D" modified="2014-03-19" version="1">MRQGKRFEITGEGLEDRLDEIRQMASELLANTVIESFDVHVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ5</accession>
    <name>W4TNZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxypeptidase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70426">
        <property type="protein sequence ID" value="GAE70426"/>
        <property type="gene ID" value="JCM18909_3744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23463" checksum="62BAA84E1290EFA5" modified="2014-03-19" version="1">MVAYGSRRASCRRPGTPEQPATPSFHLIDNGHTLLRETALVVIDAMSTGCSRVVDGQDPNEWHGWSKDIELVSELIRLWVTRYGRWGSPLYLLGESYGTIRAVSVAQRLQDTFSMYLNGIILVSLVLDFGTQDFEDLAWDRACIGFLPTYAAIAHYHGNHLKLDDHTLDRIEEAFFDNGHMPYLGCREEEADGIATFIWTSQGAPKIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ7</accession>
    <name>W4TNZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DeoR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69914">
        <property type="protein sequence ID" value="GAE69914"/>
        <property type="gene ID" value="JCM18909_3181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="29"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22023" checksum="DD5CFC468A448CCF" modified="2014-03-19" version="1">MKLRAAGVEPDTEAGIATQVVTGADAPSFSDLWRATIDRSRVRFGYRGGKHRTVDPWRMALRRGRWYLVGRDVDRDEPRLFRLSRISSAVTTVGEPGAVVSPEPEVIEAHLNRLEPPEPEEVDVTMAVAPGVRLGVMTTHAEWDGPVPEGYEVVTGGFGGYDEAATAVLRAGGRIILLAPQEARTVLAERINAVLRLEENAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP35</accession>
    <name>W4TP35_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69949">
        <property type="protein sequence ID" value="GAE69949"/>
        <property type="gene ID" value="JCM18909_3222"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="6">
        <location>
            <begin position="7"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24036" checksum="49EBB8B062CCDA55" modified="2014-03-19" version="1">MVILSKIYTRTGDHGSTRLVDNSVTAKSDLRVEAYGLIDQANASIGLAIALDTTTKVLSREVREALGIIQNELFDVGADLANPLVANPKWEPLRTVQESVDRLERWCDEFGDQLPTLRSFILPGGNPVGAQLHVCRTAIRTAERAAWRAAEVYGTGTSNDPETTPGGVNELAITYLNRLSDLLFILSRAANKAGEDSSDEVLWVPGGERKPSTQMTNDGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP51</accession>
    <name>W4TP51_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MMPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70491">
        <property type="protein sequence ID" value="GAE70491"/>
        <property type="gene ID" value="JCM18909_3818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14820" checksum="E1A71763A22D5623" modified="2014-03-19" version="1">MPPFYFGIFVVGLCLVLLTLVFRSIAVPIKATVGYLLSVLAAFGVSQLVFNRGIGLQVVNLDRPVPIISFMPIVVMGILFGLAMDYEVFLVSRMREEYVHTGDAKGAVTRGFIGSGKVVTAAAVIMISVFVFFIPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP52</accession>
    <name>W4TP52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69969">
        <property type="protein sequence ID" value="GAE69969"/>
        <property type="gene ID" value="JCM18909_3244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="4">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22319" checksum="A0C1B248B0851795" modified="2014-03-19" version="1">MIAVAGVPSRPAYGYLKHEGGVHRVQRVPVTESSGRIHTSAVGVLVMPDVDETEVDIDPAEIRVDVYRSSGPGGQGVNTTDSAVRLTHLPTGIVASCQNERSQLQNKAEAMRMLRAKVAALVAQQAADENDRMRRDQVRTVDRSARVRTYNFPENRLTDHRIGYKSRKLDQILAGDLGDVLDALHADEVRRRMAQRPEGQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPJ2</accession>
    <name>W4TPJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70333">
        <property type="protein sequence ID" value="GAE70333"/>
        <property type="gene ID" value="JCM18909_3647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5124" checksum="6164BF52A177B6A9" modified="2014-03-19" version="1">MSGALVIGESLIDVVNDEAHRGEHPGDSPMNVAITISRAGANPPRTAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPR1</accession>
    <name>W4TPR1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70214">
        <property type="protein sequence ID" value="GAE70214"/>
        <property type="gene ID" value="JCM18909_3512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7188" checksum="5DF6D64CFFB927E7" modified="2014-03-19" version="1">MVGTDDVPLAAFAPVALTTVRQPFQALGTAAIDLLVDMVERPDREHHGVLMEPELVLRSSTAPRHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPV2</accession>
    <name>W4TPV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70562">
        <property type="protein sequence ID" value="GAE70562"/>
        <property type="gene ID" value="JCM18909_3907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="332" mass="35689" checksum="F44422BB30AE236C" modified="2014-03-19" version="1">MRAGQVLGIVAHEPVQAHRAARRLAATVRPRGVNDHLLHALLRQTSVQRACGMVDRRADRPIGESMELANEVLGPVGARRGAEHSEGQQRLLANVLACAGGQVVLWVDPGWAVDAASGDHLVQTVRRRGASVIMASRDVDLVARWCDRVLVVDEHEVVADGRPGSVVADLPYPPRWLRCSLAATSSGPPMWPSSPVPKRREVGLMRNWCSGVVTAIVAGTVAVWLAMPVIDSMHAGTRDQVSSESQAMVVYLAAGLVLLAVCRWVDDGRRIWRVGLLVCLVVSNALVRVIMSPRVFGVEPVFVLPLLVGVSAGASGRILRGGRILPALQHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPW1</accession>
    <name>W4TPW1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Alkyl hydroperoxide reductase C</fullName>
            <ecNumber evidence="4 11">1.11.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 11">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_3731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a hydroperoxide + H(+) + NADH = an alcohol + H2O + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:62628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.11.1.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.26" evidence="4 11"/>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70413">
        <property type="protein sequence ID" value="GAE70413"/>
        <property type="gene ID" value="JCM18909_3731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102039">
        <property type="term" value="F:alkylhydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017559">
        <property type="entry name" value="AhpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="PTHR10681:SF121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03137">
        <property type="entry name" value="AhpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE70413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="187" mass="20831" checksum="08152DEE3E76FE68" modified="2014-03-19" version="1">MSLINTKILPFKANAFRNGDFIEVSDSDINGKWAVFFFYPGDFTFVCPTELGDLADHYEELQVMGVEVFSVSTDSHFVHKAWHADSDTVGKVNYTMIGDPNLQLTRNFDVEREGAGQADRATFLVDPDGVIQFYELTAEGIGRNATELVRKVKAAQYIYTHPGEVCPAKWEEGDETLAPSIDLVGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPZ0</accession>
    <name>W4TPZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70602">
        <property type="protein sequence ID" value="GAE70602"/>
        <property type="gene ID" value="JCM18909_3952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7125" checksum="916F6B0B60B97434" modified="2014-03-19" version="1">MTYPSHARTTGPLLAATGVAMAIVAAVIGRLRPLEPRLLGRENPDVLTSVLHAVVETLFWTAWCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ66</accession>
    <name>W4TQ66_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70528">
        <property type="protein sequence ID" value="GAE70528"/>
        <property type="gene ID" value="JCM18909_3862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="3"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6106" checksum="43B2048135AABE1B" modified="2014-03-19" version="1">MEEVEALRTTATAPLSIARAMIWTRKEAYLKYLGLGLTVQLDSFFSNRSNLAVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQA2</accession>
    <name>W4TQA2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000092">
        <property type="protein sequence ID" value="GAE70722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70722">
        <property type="protein sequence ID" value="GAE70722"/>
        <property type="gene ID" value="JCM18909_4110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="7913" checksum="C1181705C3766659" modified="2014-03-19" version="1">MGGYHGGLGSVDGQVPGGDHAAFPGDRVWVAVVDLGHASQGCPCLGEVPDDRGQAGLVRADRELADAVLLEFVEDAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQB7</accession>
    <name>W4TQB7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogen peroxide-inducible genes activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70409">
        <property type="protein sequence ID" value="GAE70409"/>
        <property type="gene ID" value="JCM18909_3727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="38" mass="3931" checksum="ABCCA8474655DFA8" modified="2014-03-19" version="1">MTGADDELAREEGPIDPHDVPTEAHPHVGGALSKRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQC5</accession>
    <name>W4TQC5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70603">
        <property type="protein sequence ID" value="GAE70603"/>
        <property type="gene ID" value="JCM18909_3954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="281" mass="29245" checksum="7343D9EE48E9A1DF" modified="2014-03-19" version="1">MVSRTDVAVLALLMIPLESADSAGLAFEQAFLDLPTYITSTPSVAAWLVVAVLGLLVGLLALLSTHLGGLVVASLVTVLAALPVPVTGAISVGLNHDFATDSGALAAVGMTVAAACVLVEVLDGPRPALTDRLIWKQRIGAAVALAGGIIVTWQGQAGRSWGSDRWGVARIIVLVATAIWVVITWLPRTRMLSWLGVTMVAVVLIVTGAANQLVPPRYLIGQTPAVNYLGYELPPAPTAAILLAPGRPNIGFWTLSVLGIVGYYVAVRTLKRRGEAGLGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQS8</accession>
    <name>W4TQS8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70589">
        <property type="protein sequence ID" value="GAE70589"/>
        <property type="gene ID" value="JCM18909_3939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12396" checksum="E078B9243A7FEFA0" modified="2014-03-19" version="1">MSLSVTTLMVIAVRTRTADAILAALDPEQVKVAKTFDVPVCVIAGAGTGKTRAVTHRIAYGAVTGKLDPRRTLAVTFTTKAAGTMRGRLADLGVVGVQARTIHSAALRQIKFFLASCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQU9</accession>
    <name>W4TQU9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rimP</name>
        <name evidence="6" type="ORF">JCM18909_3968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70614">
        <property type="protein sequence ID" value="GAE70614"/>
        <property type="gene ID" value="JCM18909_3968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="165" mass="17971" checksum="F7795E1B37145C88" modified="2014-03-19" version="1">MSQVGLELDRVDVVPAGRRRLVRVTIDGDGPDGHGPSLDEISEATAEISHCLDDSGAMGESPYTLEVSSRGVSTPLTQPRHYRRNIGHLVRFTLNPAEGQKSGETFDGRIAEAGEEVVTLEVEAENSKPHKPVYTTREVQLADVAKAVVQVELNRRDAQASKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQZ3</accession>
    <name>W4TQZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CobN component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000061">
        <property type="protein sequence ID" value="GAE70664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70664">
        <property type="protein sequence ID" value="GAE70664"/>
        <property type="gene ID" value="JCM18909_4035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="4744" checksum="B27062664DBA638C" modified="2014-03-19" version="1">MTTLSFFSATGGELTLVSQACHGYALVVSTSPSWAAPRSRSPTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDZ1</accession>
    <name>W4TDZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA dihydrouridine synthase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_15</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66986">
        <property type="protein sequence ID" value="GAE66986"/>
        <property type="gene ID" value="JCM18909_15"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850693" evidence="2">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Dus" evidence="3">
        <location>
            <begin position="54"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE66986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="422" mass="44666" checksum="1F6CA8B9B1367CE1" modified="2014-03-19" version="1">MAMRVVMSRCATGAGTTVSAEPDCHAYHGLVFSDPLTLIAPSGGTVSVDTPVVLAPMAGVTNAAFRQLCAEQGAGLYVCEMITSRGLVYGDHKTHGMLAFAECEDVRSVQLYGVDPGMVGEATSILCEKYGVNHVDLNFGCPVPKVTRKGGGGVLPWKLDRFAAVVSAAVQAGDAHGVPVTVKTRIGIDPDHITYIDSARAAVDSGAAAVCLHARTVAEAYAGHSHWDAIGELVKTVDVPVIGNGDIWEASDAVAMVGQTGCAGVEVGRGCLGRPWLFRDLADAFAGRDTTTLPTLGEVCAMIRRHAELLVKYQGMHGLVDMRKHMAWYLKEFPVGGETRHALGQISSFDELDSLLATLDHDAPFPVKELGKARGRQGAPRRKVVMPHGWLDTHTLDDDDLSAAEIDAPGDDLASGWSRDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE56</accession>
    <name>W4TE56_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C-terminal domain of CinA type S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_96</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67061">
        <property type="protein sequence ID" value="GAE67061"/>
        <property type="gene ID" value="JCM18909_96"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="16314" checksum="E5B528FC0859DCEF" modified="2014-03-19" version="1">MTGDDGARRLIAVLSEHGLTAATCESLTAGLVAATITTVPGASTVFRGGLVTYASELKSTLAGVDAQWIAENGVVNSITAAQMAMGCRKVCGADVGMACTGVAGPDPQDGEQAGTVFIAVVYRGPVVKRLQLKGSREEIRCGTVERLLDLGCEVVLGSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEI3</accession>
    <name>W4TEI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein co-occurring with transport systems</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67201">
        <property type="protein sequence ID" value="GAE67201"/>
        <property type="gene ID" value="JCM18909_244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="4232" checksum="93CAA84C96B096F0" modified="2014-03-19" version="1">MTLACRADRGSQMAIDLAKLLGREVRLTPAGQCWADIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEN6</accession>
    <name>W4TEN6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_11</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66982">
        <property type="protein sequence ID" value="GAE66982"/>
        <property type="gene ID" value="JCM18909_11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE66982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="6976" checksum="BC30DFBEB15A60B7" modified="2014-03-19" version="1">MDHLIQAGGTVDVMTGTAPDADSVPQPHAEAEQALDFASCIGCGACVAACPNGAAMLFLPARSCRTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TET6</accession>
    <name>W4TET6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67465">
        <property type="protein sequence ID" value="GAE67465"/>
        <property type="gene ID" value="JCM18909_527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7062" checksum="567C2ED104D80DA8" modified="2014-03-19" version="1">MELSTTAYWECVIALLLGWLVWGESLTLTSSIGGALILLGGAGPVVFELFGRDHLPKDERSVPDCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEW3</accession>
    <name>W4TEW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67495">
        <property type="protein sequence ID" value="GAE67495"/>
        <property type="gene ID" value="JCM18909_558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848725" evidence="1">
        <location>
            <begin position="50"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="80"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="16627" checksum="223CB53844B1A781" modified="2014-03-19" version="1">MLPGRARRSQKASFAMPAIPKSLRRAVAVSILPVIMLAGCAGAPKDSSASSSVSASQSNAGPITITNCGQKVTLDKPATRAVTLNQGATEDVLAIGGESKLAGTAYLDSGIPKKWKKAYDSVKVLAKEYPSKETFLSAKPDLAVYLVFECFHRQGGGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF79</accession>
    <name>W4TF79_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mutator MutT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67625">
        <property type="protein sequence ID" value="GAE67625"/>
        <property type="gene ID" value="JCM18909_698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12010" checksum="7BC86DBC63CE53CE" modified="2014-03-19" version="1">MMTPILTTLGFVMHPDGERVLMVHRIARPGDEQLGKYNGLGGKVEPGEDVVAGMKRELREELRSRLTPCAYVAPSPGLGSADTGRTISDLSSSSTRGIPLPTPSLTPMKRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFA5</accession>
    <name>W4TFA5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67650">
        <property type="protein sequence ID" value="GAE67650"/>
        <property type="gene ID" value="JCM18909_724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6603" checksum="4DFC33A8B269CF96" modified="2014-03-19" version="1">MAYQLVGGLRQSMFYTGARTIDELHERGRFVRITSAGLRESHPHDIQMTVEAPNYSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFA9</accession>
    <name>W4TFA9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67118">
        <property type="protein sequence ID" value="GAE67118"/>
        <property type="gene ID" value="JCM18909_157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_gyraseB" evidence="5">
        <location>
            <begin position="109"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="262" mass="28698" checksum="F1EC7BD9CAD63BB7" modified="2014-03-19" version="1">MGMSFRRGVPGVFEGEGPDAPFTSGSGVRKVGKAKRGVTGTRVRYWPDRQIFLPDAKLSWSKLADRARQTAFLVPGLEIVITDERGIQTDPETDDVLETVSETMRFDGGISEFAEYLATDQPVNNVMRLQGEASFTETVPMLDENGGMTPTDVDRDLGVDIALRWGTGYDTTVRSFVNIIATPKGGTHVQGFEQGLLRAFSAGLEGTRILKSSEEIVKDDVLEGMTAVVTVSLAEPQFEGQTKEVLGTPPVRRSWRALLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFD3</accession>
    <name>W4TFD3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-succinyl-L,L-diaminopimelate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67471">
        <property type="protein sequence ID" value="GAE67471"/>
        <property type="gene ID" value="JCM18909_533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="53"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="242" mass="26777" checksum="C8FF5EEDA7FA1637" modified="2014-03-19" version="1">MRDVTWAFYECEEIAAEYNGLEKIASRRPDLIDGDFAILMEPTDGRVEGGCQGTMRFTLEVPGRAAHSARSWVGHNAIHDLSAVLERLNRWQERDPFVEVDGLAFREGLNATMLDAGVAGNVIPPTATIQINYRFAPDKTTEQARQYMEDLFHEWPMNVLDLSAPARPGLDRPLAKSFVAAVGGEPGPKYGWTDVARFGQLGIPAVNFGPGNALCAHQVDECCRLGSLDECYRALHTWLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFG8</accession>
    <name>W4TFG8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67272">
        <property type="protein sequence ID" value="GAE67272"/>
        <property type="gene ID" value="JCM18909_318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28700" checksum="8F0DF3950D1AE708" modified="2014-03-19" version="1">MHKARLLPPAKQIPVTATTRFDIASNTKMYAVNLALQMLVGQGRIDLSRQVCTFPGWEAFRDESTVYTGSWTVGGPGGIKTPFTGKKTIRLVDLMHHRGGLVPDPQYPNATVAGELYLQNLDDISNRTDVIDRICRTPLMYAPHTERAYSDVDYMILGLIVEQVVGKRLDEYLQESVYRRLGLERTEFRPLDVSTPPDLIAATELNGNTRDGNVDFGTRPDGSPVFIRTQTIRGQVQDEKAFYTMSGVSGACGTFLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFH3</accession>
    <name>W4TFH3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate-ammonia-ligase adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67516">
        <property type="protein sequence ID" value="GAE67516"/>
        <property type="gene ID" value="JCM18909_580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6229" checksum="010ADF0B29831166" modified="2014-03-19" version="1">MVVRGRPSDVIPSDSTALDVIAKASGMGQGASEHLVEDHLRHCRRASRVVDAVFWNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFK5</accession>
    <name>W4TFK5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67755">
        <property type="protein sequence ID" value="GAE67755"/>
        <property type="gene ID" value="JCM18909_836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5557" checksum="2F083CE9EC943B34" modified="2014-03-19" version="1">MVALLQEGTIIRVGTHSELLATVPEYRELLSAYDAEQGDVRRVRGESGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFK6</accession>
    <name>W4TFK6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">apt</name>
        <name evidence="12" type="ORF">JCM18909_359</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TFK6"/>
    <dbReference type="EnsemblBacteria" id="GAE67312">
        <property type="protein sequence ID" value="GAE67312"/>
        <property type="gene ID" value="JCM18909_359"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="31"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="18419" checksum="754A02D1F0B91FA3" modified="2014-03-19" version="1">MTYRKDLIASLIRDVPDFPEPGVTFKDITPLLANPNGYAAAISELVDTASRDVDVVLGMEARGFMFAGPVALSLGAGFVPVRKPGKLPGDVYSQSFVLEYGSATLTVHQDAVQPGSKVLIVDDVLATAGTVRATASLVEQLGAELVGVSVLIELSALGGREKLDRAGIGPVNAVLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFM3</accession>
    <name>W4TFM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67775">
        <property type="protein sequence ID" value="GAE67775"/>
        <property type="gene ID" value="JCM18909_858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5802" checksum="3B7619981E817AD7" modified="2014-03-19" version="1">MRETGGSELTSQQMGPSMASIPWNVPFFGWLDFSMMMRRVRNEMALTAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFU7</accession>
    <name>W4TFU7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ruvB</name>
        <name evidence="8" type="ORF">JCM18909_355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67308">
        <property type="protein sequence ID" value="GAE67308"/>
        <property type="gene ID" value="JCM18909_355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="52"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="340" mass="36158" checksum="398E009056DE4B83" modified="2014-03-19" version="1">MEHSPVDPSAEPPEKAEEAALRPGALAEFGGQQRVADQLGLVLAASKSRGTTPDHVLLSGPPGLGKTTLAMIIASEMSAPIRISSGTAIQHAGDLAAILSSLVPGEVFFLDEIHRMSKPAEEMLYLAMEDFRVDVVVGKGPGATAIPIEIPPFTLVGATTRAGLLPGPLRDRFGFTAQLDYYEVADLERIVTRSAGVIGVELAEGAARTIASRSRGTPRIANRLLRRVRDWADVHHESPVTPQGAETALDLYEVDPLGLDRLDRAVLHAVCLKFGGGPVGLSTLAISVGEEPQTVEEVAEPFLVRLGFLMRTPRGRVATDRAWRHLGLEPPPGSSGEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG06</accession>
    <name>W4TG06_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67069">
        <property type="protein sequence ID" value="GAE67069"/>
        <property type="gene ID" value="JCM18909_104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11794" checksum="519FEB02DDE40A90" modified="2014-03-19" version="1">MSVTDFIVKAADAISAARPGARRESLEAHVRRMDTIEEIATSFPGVVRAFALQAGREVQILVDPGAVDDHQASRLARQIALAIGEQVTVPGRTRVTVIRSFQAIETVGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG67</accession>
    <name>W4TG67_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane alanine and valine and leucine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67144">
        <property type="protein sequence ID" value="GAE67144"/>
        <property type="gene ID" value="JCM18909_184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18453" checksum="081D39DA0CE5746E" modified="2014-03-19" version="1">MMRHWTRLLRTDTSTGTKERRRWQHSRIINGIGLVGTGIVLIIILASKFIHGAYLALIAMAVVYVLMTSIKKHYDSVARELELNSPSDRALPSRVHAVIMISDLNKPTMRLYSSRRLLSQLSWRLSSSTSTLTLRSVCWSAGTRRTSTSPSGLLLPHIARSPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD0</accession>
    <name>W4TGD0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67209">
        <property type="protein sequence ID" value="GAE67209"/>
        <property type="gene ID" value="JCM18909_253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="12084" checksum="A69B450D398AA6ED" modified="2014-03-19" version="1">MNKLHLTTLGNGQQDVYWCHGVFGQGKNFTRVAKDLLATNPDAYRCILVDLPNHGRSPWTQTFFLIATWPTPWQPPSKPPVGTVQPTCWVTRWVAKLSCGRFSTILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF7</accession>
    <name>W4TGF7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68040">
        <property type="protein sequence ID" value="GAE68040"/>
        <property type="gene ID" value="JCM18909_1147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="108" mass="12072" checksum="62B03830FF1E76AD" modified="2014-03-19" version="1">MVTAPVLIGLAGMNAVLEETVMIGYLFTRWRQIGWSTTMVIVTSAIIRGTYHLYQGWGGFIGNIVMGLFLGWVFSRRCRLLPLVVAHAFLDIVSFLGYAYLAGRVSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS1</accession>
    <name>W4TGS1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67956">
        <property type="protein sequence ID" value="GAE67956"/>
        <property type="gene ID" value="JCM18909_1058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17461" checksum="F37DE3668C8B113D" modified="2014-03-19" version="1">MGGLMLGVGLVGCSDSEEGWESVTVDRITVSHPTEWVEKPPENENFTKNFTDGPHDMQIAGHYSDDTEPTLAWSVLEFMISGTFEGYDSKGYQEITVKGAARAIKCPFDFTYKGKSARGYWLVASGVLPTEGSAIVLLRLPRDDTNLVDKIITSMSFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS3</accession>
    <name>W4TGS3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphomannomutase PmmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67732">
        <property type="protein sequence ID" value="GAE67732"/>
        <property type="gene ID" value="JCM18909_812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_II" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="2">
        <location>
            <begin position="70"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="241" mass="25890" checksum="3E6C2D07E2F1C956" modified="2014-03-19" version="1">MPEFIGVTEQLDPDPDFPTVAFPNPEEPGAIDLAIAQAHKHDADVVIASDPDADRCAVAAVIDGDWRMLTGDELGSLLGDDALRRGLDGVYANSVVSSTCLGRMAKAAGREHHMTLTGFKWIGRVPGLVFGYEEAIGYCCDPSHVPDKDGITALATILRLVGELKASGTTIAERLDEIWATHGLHRTSQLAVRVTDMSIISEAMDRLRNQPPTTLLGDRVDVCDFDDPSNGPGCHSRTRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ4</accession>
    <name>W4TGZ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67404">
        <property type="protein sequence ID" value="GAE67404"/>
        <property type="gene ID" value="JCM18909_462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16006" checksum="428E1C187CFBA897" modified="2014-03-19" version="1">MALQPQYNLLHRADVEDPQGYGQLASEYSLALFPYFSLASGFLTGKYATRDDLHGVARESMMAAYLPDAEHEKAAFAVLDQLRQIAGDHRVEVTSVSLAWLLAKGVTAPIASARTIDQLDALLAAPDLVLSSDEVCALDEVSAVFAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH07</accession>
    <name>W4TH07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68061">
        <property type="protein sequence ID" value="GAE68061"/>
        <property type="gene ID" value="JCM18909_1173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6635" checksum="45197B60DDB2F347" modified="2014-03-19" version="1">MELDAATVRYHSGWQLGPVSVTFPVGVSALVEPNGSGKTIMLGVLTGIRRPRTGYYVEAVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH21</accession>
    <name>W4TH21_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyruvate, phosphate dikinase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Pyruvate, orthophosphate dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67832">
        <property type="protein sequence ID" value="GAE67832"/>
        <property type="gene ID" value="JCM18909_919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilizers_C" evidence="4">
        <location>
            <begin position="14"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00032883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19788" checksum="C43893F890270FB1" modified="2014-03-19" version="1">MHEMITADTPEERQAAVDKILPMQQDDFEGIFTAMKGLPVTVRLLDPPLHEFLPNLVEQSLKVQKMENQGADAGELDKERRLLAQVKKLHEQNPMLGTRGCRLGMLYPEIPDMQARAIIRAVLSVLKKEGETVQIHIMIRWSSPQSSLRPIVGSSSRPSMKSSRLPVPRSTSRSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH74</accession>
    <name>W4TH74_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ORF">JCM18909_1254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68136">
        <property type="protein sequence ID" value="GAE68136"/>
        <property type="gene ID" value="JCM18909_1254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15723" checksum="88E3A36A542F7E09" modified="2014-03-19" version="1">MCGCRPFKHTKEKIVAVPKRKMSRSNTRHRRSQWKTVATKLVTCANPACGEKHLPTPPARLAVGTGRAATVVRLSRPEIDTVHASRDQNIGRPDVEDWPFLALLEELGIRCDPQLLDLALTHRSYAFENGGIPTNERLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH84</accession>
    <name>W4TH84_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67494">
        <property type="protein sequence ID" value="GAE67494"/>
        <property type="gene ID" value="JCM18909_557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6827" checksum="DDEE2D915E1A71E6" modified="2014-03-19" version="1">MIGVRGQATTGRRQVVFGLDFVSVPGAFPVRMVPVVQVGADQSYRCASAPAFHRIPALVWSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH90</accession>
    <name>W4TH90_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67798">
        <property type="protein sequence ID" value="GAE67798"/>
        <property type="gene ID" value="JCM18909_883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8749" checksum="50A982A22147BD84" modified="2014-03-19" version="1">MHGEAIRGTRPWGHGVYGDQRIVKRGETVYVHLLDGDALHLPDELKVFDVSWIGSQSKQTSVPCELVNQPVKVARLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA0</accession>
    <name>W4THA0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate-ammonia-ligase adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67514">
        <property type="protein sequence ID" value="GAE67514"/>
        <property type="gene ID" value="JCM18909_578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="7882" checksum="59CFB26BB4F5C8E2" modified="2014-03-19" version="1">MGKCGAQELNYISDVDVIYVAEPANDDVSGTSAVTIATKLAASVARMCSAHSGAGSIWQVDAALRPEATPDRWCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF9</accession>
    <name>W4THF9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67873">
        <property type="protein sequence ID" value="GAE67873"/>
        <property type="gene ID" value="JCM18909_965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="16238" checksum="0478A38A33B335B0" modified="2014-03-19" version="1">MIPELVAFDLDNTLAPSKTRLPQEMARIVARLLDRTSVCVISGGQFGQFRTQVVEALVDAPRLDRLHLLPACGTQYYRCVDGEWQRIYVEALTDDEKSRAMEAVESCARDLGLWEEHTWGPVLEDRESQITFFRAGSAGPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ2</accession>
    <name>W4THJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67972">
        <property type="protein sequence ID" value="GAE67972"/>
        <property type="gene ID" value="JCM18909_1074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="4">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="318" mass="36164" checksum="F9DE4BA65AA86D32" modified="2014-03-19" version="1">MLKPMLARGELQTIGATTLDEYRKYIEKDAALERRFQPIQVDEPSIPLAIEILKGLRDRYEAHHKITITDEAITFAANLASRYIQDRFLPDKAIDLIDEAGARMNIRRMTAPPDLREFDERIARVRVEKEAAIDAQDFERAAGLRDDEKKLLAEREAKEEEWKQGDESVPAVVGPDEIARCSLELPVFRSSSSRRRNPSVCSTWRTRSASATSARRTPSKPCAALSDAPAPASRIRSVRQVRSFFLLARRVLVRPSSPRRSPSSSSVTRTPHHPRHERVLRETHRLADVWVPAWIRRVRGGRPAHREGAPQAVQRHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS1</accession>
    <name>W4THS1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67724">
        <property type="protein sequence ID" value="GAE67724"/>
        <property type="gene ID" value="JCM18909_804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="18938" checksum="A35A21FE021D4357" modified="2014-03-19" version="1">MPPGWSVLGLTLEVVGVGLLAWVVGVQGSTWLIVLTLIVYGVGLGLASAQLTSTVLHDIPADQSGAGSATQSTVRQLGSALGAAIAGTALGSAMNHTIPDAVASISAVPTRVLDKLVHITEAQPVRPFQDFAMRLPTAPSFARSVHPAPPSSATSRPVSLTQQRGRSGCRRCFWSSVCSGRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU0</accession>
    <name>W4THU0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galacto-N-biose-/lacto-N-biose I ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68505">
        <property type="protein sequence ID" value="GAE68505"/>
        <property type="gene ID" value="JCM18909_1648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="3830" checksum="E3C4F87E83C18177" modified="2014-03-19" version="1">MNEKGAGAAAGKAKVGDIFQTAQDTSVQALKDAGLPVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI19</accession>
    <name>W4TI19_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68078">
        <property type="protein sequence ID" value="GAE68078"/>
        <property type="gene ID" value="JCM18909_1190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9033" checksum="28F755A97667A278" modified="2014-03-19" version="1">MTTSTTHRPAYQRPELSVHERVDDLLSRMTPAEKIGQMTQLPVYSDPDPIMDSIPLAPYSTVITTLLTTASTTPSTPDSASPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI34</accession>
    <name>W4TI34_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68615">
        <property type="protein sequence ID" value="GAE68615"/>
        <property type="gene ID" value="JCM18909_1762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17488" checksum="7FABD56868D2C61E" modified="2014-03-19" version="1">MSGSVSVMSPQSGLRARRVAAVHIVEVVATCLFLVAVGQIIGGRFEDFAPAPGWYWAMSIGGVVAAVAAGAAVSMSGRHARAEEAALHPKVLDVLYRRSLTGPPAADEGERVITLATDNAERVSEYRQVFFFLTSLPPWPLRCWCVWSFSSVWTGSPAWSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI50</accession>
    <name>W4TI50_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68431">
        <property type="protein sequence ID" value="GAE68431"/>
        <property type="gene ID" value="JCM18909_1569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7395" checksum="F00F0AE5B3A6C606" modified="2014-03-19" version="1">MSSSLVILIVGGFFLVRQATAGIVEAKRTSAIAETTATINRIQGQLRDTDLRTASLYERLNLLADDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI82</accession>
    <name>W4TI82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68242">
        <property type="protein sequence ID" value="GAE68242"/>
        <property type="gene ID" value="JCM18909_1365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="5">
        <location>
            <begin position="155"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="321" mass="33845" checksum="5728C275324D35FD" modified="2014-03-19" version="1">MPIKPHKLGIIGVGRVGDAVLSDAMMSGLFGEICVIDVNEKLAAGQALDQHHATALPNVTNVAVYAGNYDDLSDADVIIVTAGPSIDASNGPVTGAARRELAATNGKIIRSTMTEITSRNHEAAIIICSNPLDALVHIASTEFDHPQGLVLGTGTILDSARMCRVVADHLRVDPDYVRGYMIGEHGPSGFPMFTGVNVGGVGFDGLAELFDTDPMDRNELTTRINDAGTAVFNLKGWTSAGIGQSAVTIARSILLNEHAVYPVCTTLHGQYGHDGDVSMSVPCVIGAVGVERILEVPLDDWEQEHLANTIKAIQETVEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID4</accession>
    <name>W4TID4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68193">
        <property type="protein sequence ID" value="GAE68193"/>
        <property type="gene ID" value="JCM18909_1315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13304" checksum="B4049A79261605A7" modified="2014-03-19" version="1">MPAWFPPKQTPLVTQLIGLLGQFGQVVSAVGLVAMVNSSGWRSTYLLAAGGAAVAAALAFLLIRDAPPGVEPERTEANVKQLPHQVAEVISHPSTRLAFLGTHVVEFRRNRIFADVGYALPHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID9</accession>
    <name>W4TID9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sucrose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68536">
        <property type="protein sequence ID" value="GAE68536"/>
        <property type="gene ID" value="JCM18909_1681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19687" checksum="F832A56146CF8478" modified="2014-03-19" version="1">MMYQGGLNCMLGAFNAIPPDYVPDSTLGKVSAFGGAGYLLAQIIGAVIAGAFVTHPSQGFLMAAWIMLVSSIIVVILLPPHPLRHRSPRPPVIWRQFGAQMRPPSDGQFWWILVGRFLFVISLFMVMQFQLYIATDEMGMTRATAGRLIAMNSQSSPSRQSSLTSSRVRGPTRSSAASPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL8</accession>
    <name>W4TIL8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lsr2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67969">
        <property type="protein sequence ID" value="GAE67969"/>
        <property type="gene ID" value="JCM18909_1071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024412">
        <property type="entry name" value="Lsr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042261">
        <property type="entry name" value="Lsr2_dimerization"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11774">
        <property type="entry name" value="Lsr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11782" checksum="6F9B77370BAF50DF" modified="2014-03-19" version="1">MAQRVRVDLVDDVDGSPAEESVNFALDGVNYVIDLSAENASKLRDALSLWVDHARRTGGRRTRGRRPTGGPTANEVRQWAKSQGYEVSERGRVSNEIREAYQRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR8</accession>
    <name>W4TIR8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68039">
        <property type="protein sequence ID" value="GAE68039"/>
        <property type="gene ID" value="JCM18909_1146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10593" checksum="9BDF4E57F4CE8DF6" modified="2014-03-19" version="1">MLAVSLGQSAWYSILRMIERLTRGVPMNQQTSTLNSSVTPGRPWLDLLYQLSDIAFGVVPALLAVLLLAQIKPPRQGVCRALGWKRRDGDVMSELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIT7</accession>
    <name>W4TIT7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68427">
        <property type="protein sequence ID" value="GAE68427"/>
        <property type="gene ID" value="JCM18909_1565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010860">
        <property type="entry name" value="CAMP_factor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07373">
        <property type="entry name" value="CAMP_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848775" evidence="1">
        <location>
            <begin position="29"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30276" checksum="7B256D93F00D1E9C" modified="2014-03-19" version="1">MKVKFLAAPLVVGALMAPAAFSGATAHAAPVAPIVAVSATQPNKTLSVAEAQKELQVVNARIASLLDTQKSAKEAFAPANVINIIGKLLETAKRIKEALVNIIKGGVAFLKSIPTRVELLVTMVDTVNGAAHTLQDKAQPAHSHVFLELVHASVLLVTVSATNDQLKDEMAAVKKALAEAQKMPDIKPNDVATFYTKAKLARVLRQIRFDRNTCVLPFKRLGTIYFLSRALLKATGVLMEPLVRVSEVDQAITDVKAAYQDALKAPNRLLTPAVPAVCAPAPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIT8</accession>
    <name>W4TIT8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68064">
        <property type="protein sequence ID" value="GAE68064"/>
        <property type="gene ID" value="JCM18909_1176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19067" checksum="AE3DA8F9ED66F9DE" modified="2014-03-19" version="1">MLVTMVMAPGGGRWWLWVCSGILAAAIAIGAGMVAGLEDVWKSSGDWRCRSVGGRGSMACVSGDVSWRLDEYATAVGRVDDLLGASGGKRPLLYAPQGGPNRAGYIPVRIPVSTSSSPSEWATYFHQPLLADNLLRVNKSNASRCDGAIETLDDALVSVMDGQSFDPSSLRSMVSLARACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ10</accession>
    <name>W4TJ10_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68920">
        <property type="protein sequence ID" value="GAE68920"/>
        <property type="gene ID" value="JCM18909_2095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="8"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14008" checksum="7EF6C15AC4E7BA18" modified="2014-03-19" version="1">MALEAVQLEDRLKDKPNQLSGGQLRRVGLAQALVGEQPIVLLDEPTAGLDPAQKHVFRNLLTELGATRSFVVSTHDTSDVDSTYNRVVILHKGRIAYDGSTDEFLMHGAGSSHAAEAAFLDVVGVSEQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ11</accession>
    <name>W4TJ11_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsE</name>
        <name evidence="8" type="ORF">JCM18909_1538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68403">
        <property type="protein sequence ID" value="GAE68403"/>
        <property type="gene ID" value="JCM18909_1538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="228" mass="25581" checksum="0B881476297CA0CF" modified="2014-03-19" version="1">MITFDSVTKTYTGQSQAALSDVNVDIDKGEFVFLVGQSGSGKSTFIRLILREYRPTRGTLYVAGKNLNQLRSWKVPALRRQIGTVFQDFRLLPRKTVYENVAFAMQVIGKPTKEIRSVVPETLELVGLDGKQKRMPDELSGGEQQRVALARAFVNRPKILIADEPTGNLDPDTAVGIMKVLDRINRTGTTVVMATHDSTIVDQMRRRVIELEFGHVVRDENEGVYRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ15</accession>
    <name>W4TJ15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68925">
        <property type="protein sequence ID" value="GAE68925"/>
        <property type="gene ID" value="JCM18909_2100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7965" checksum="34AE75476D202F2F" modified="2014-03-19" version="1">MVAAQALVTTGLGQVLGFLVGFVPVVVMTCADSRWPTPMPLPWLALIVFVPPVLLALVTMVAVPVPRPRMQRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB3</accession>
    <name>W4TJB3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF559 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68498">
        <property type="protein sequence ID" value="GAE68498"/>
        <property type="gene ID" value="JCM18909_1640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007569">
        <property type="entry name" value="DUF559"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04480">
        <property type="entry name" value="DUF559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF559" evidence="1">
        <location>
            <begin position="179"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="293" mass="33469" checksum="FF0F4D1C34253330" modified="2014-03-19" version="1">MELVDILEANGGVAKISSVGRVARQARRAAREGYVIRPLPRIVMTAMAARHPEAWMRAVRLWRPSTVFTGRAALYLAGMRDLKVTEIDVIVPHSMPRCSRRPWLRFHRAGSEPVIEDRYGVRTTCAYTCFWLALRGDWEAATECLRKGYVATEDLRGVRPKVARKAPSSVVRRVLRQLLDRPWSVAEREIHALFRRYRVSGWKANERLWIDGNVVFPDLWFKKENVVVEIDSYAFHGRPADYEATARRHALLVGAGLRVIRITPNMIRDNPELVLDTVRSALWGRHRGVVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD1</accession>
    <name>W4TJD1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68518">
        <property type="protein sequence ID" value="GAE68518"/>
        <property type="gene ID" value="JCM18909_1662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046112">
        <property type="entry name" value="DUF6049"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19516">
        <property type="entry name" value="DUF6049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="320" mass="34204" checksum="F8659ADAA10CE329" modified="2014-03-19" version="1">MAIIDPAAELDNSSFKTLAKELSPSIVLTCAASVRKGVREDFGVKIIGLADTVRTGGHPQSNSDSQRRGMLLSQALLMTRESIPAVTLVTTVNDVRATAPIGWLHLQNLSTILNGAKPGLHLPESHAGNTILKDSWWQIQHDVGVDADSWSDLVGASPETASLTSAKFVSRTLSASLKDREAWATGVMRPASEVIAGNGLVLHSASHFVMSSSRNEFPLTITNSLAQTVRVKVVVTSENPQRIDIPDTQVVAIQPKETQTIKFAPKASSNGVVEMQAHLSTPSGRLLGSQSTFVVKATQMDDVAGSSSSCRHWCSSSRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE2</accession>
    <name>W4TJE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LSU ribosomal protein L25p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69070">
        <property type="protein sequence ID" value="GAE69070"/>
        <property type="gene ID" value="JCM18909_2253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="6">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20550" checksum="676FD26E6AAAAD21" modified="2014-03-19" version="1">MIDWPPTWASSRRAVLRQREGDATMADIIHLKAEQRTEFGKGAARRIRRDDKVPAVMYGHDHDPIHVTLDGHATLLALRTENPLLSIEIEGQKSMLALPKDVQRDVLKGFVRHVDLLTVRRGEKVDVNVALRITGESAPGTIAMTEFNEIEVQADLLNIPEVIEIDVTGLEPVRRFTLRPQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJF8</accession>
    <name>W4TJF8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible toxin to DivIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69090">
        <property type="protein sequence ID" value="GAE69090"/>
        <property type="gene ID" value="JCM18909_2274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11076" checksum="D4DEC71AFF0D44F4" modified="2014-03-19" version="1">MTERLGEDEELADQYRRAHESYIADRVVIGEDAGLVPVPEIDGISAGGMPTRVKCLHALAGHALAVGPGVNPFGDEVVAELGEFWCDPCTPEHHEPESGRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW9</accession>
    <name>W4TJW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68728">
        <property type="protein sequence ID" value="GAE68728"/>
        <property type="gene ID" value="JCM18909_1882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14635" checksum="A58B1CACC02996E5" modified="2014-03-19" version="1">MIRYRLEDYVKGGWLPNSDADTLSALRRRQWAAVVALSQGPRRWWHTLEFLRVGTDLAYLRDAIVRGLDDDPGPRQIELINRMNVLRPAAITVARGAKLSKPRLPAFLKRRRNQPVNNELQWAPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB9</accession>
    <name>W4TKB9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68957">
        <property type="protein sequence ID" value="GAE68957"/>
        <property type="gene ID" value="JCM18909_2134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018730">
        <property type="entry name" value="DUF2273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10031">
        <property type="entry name" value="DUF2273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6432" checksum="BA0DB30AB7447BFB" modified="2014-03-19" version="1">MNASRIGALVGLLLGVIAVCVGVWQAIVVLVLGLLGLIIGRIIDGQLDVHDIFGKPSQRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG3</accession>
    <name>W4TKG3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69425">
        <property type="protein sequence ID" value="GAE69425"/>
        <property type="gene ID" value="JCM18909_2637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7295" checksum="524E613649618F1C" modified="2014-03-19" version="1">MYWCSVVALAILGLIIGVLTQIWLEKRWWHMLVIVIPAVFIVAGIFFSGSPSRKKTFRRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG9</accession>
    <name>W4TKG9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADPH-dependent mycothiol reductase Mtr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2203</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69022">
        <property type="protein sequence ID" value="GAE69022"/>
        <property type="gene ID" value="JCM18909_2203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="150"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29775" checksum="7E298F2E005E4BC3" modified="2014-03-19" version="1">MTVINRSGRMLRHEDREISQRFTEQMERRVRLRVAEGLVGVDRDPGGHLVVLTVDGDGVDYDYPADVVLNATGRVSNGDRLNLPAAGVDVDDDGFVVVDKHQRTNVEHIWALGDVCSPWELKHVANHEARVVRHNLLHPDDLASSDHRFVPHAVFSNPQVASVGATEQGLLQSDTPYAVYLQEYADVAYGWAMEDEGHCVKLLGDPQTRTLLGAHIIGPQASTLIQTCIQGMSVGQTVDEMARGQYWIHPALSEVVESALLGLGKEMDTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI8</accession>
    <name>W4TKI8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ThrE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68923">
        <property type="protein sequence ID" value="GAE68923"/>
        <property type="gene ID" value="JCM18909_2098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="271" mass="28555" checksum="20970FDBD5B96C49" modified="2014-03-19" version="1">MEPTLALNLGDAEMAIMQARRVVDLVTRVAVMAISVGGSASEAVAIALRITATYGVTVHIDITNTSVIVTQHRGLDEDPITALRVVRSRSNDYQRLGELQLLVDDICDKTVGLEEAADRLAAITRSPRLYRQWFVTMNIGLMGAGLSTLFGGTVMDGVLSFFSTCIVDATVQAMARKRITNFFAQAAGGAIATAFALIVMVYMAASNRPLPLSPSLIVASGIVSLLAGGSFVAASQDALDGYVVTSSGRFLEGLYKPVASSSASSRRCGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK6</accession>
    <name>W4TKK6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanine-D-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68694">
        <property type="protein sequence ID" value="GAE68694"/>
        <property type="gene ID" value="JCM18909_1845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="12929" checksum="66DB175CD6B582C4" modified="2014-03-19" version="1">MTNSCVYNVADPATEHMVEDADVVEGARAIGFTTGTPGPSMIGIVDGLIVDRAFVEQRATSAMELARLEDVHPFAPHNVENALAAAALTRSFGVPAPAVGQGLRDLHLGGHRIETVHQAGGITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY3</accession>
    <name>W4TKY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-threonine 3-O-phosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2859</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69620">
        <property type="protein sequence ID" value="GAE69620"/>
        <property type="gene ID" value="JCM18909_2859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="454" mass="47818" checksum="424B9F439A162713" modified="2014-03-19" version="1">MRLPRILIAAPASGGGKTTVATGLMAALRASGRTVAPFKVGPDYIDPGYHSMASGRPGRNLDSVMCGDELMAPLLAHGFVTPDPADVAVIEGVMGLFDGQLGTGRGSSAEIATTTRTPVVVVVDTAHASLTHAAVVAGLATFDPDVTVAGAILNRVASPRHGAEVARGLAQLGIPVLGQIPRTESIFVPSRHLGLVPAGEWEDSATKVAGLGDLIAEYVDLDAVMDLAATAPDLDVEPWDPAAALESAGWQGHPFGESPLVGMFAGRAFTFRYLETTEMLTAAGFRLVDVDPLTDRRLPDGIQGLYLGGGFPQMHATDLETNSELADDVRSHAEPGCRSSPSAPGCCICAVTLTGTRWLACCRWMRPWQSGSRWGTASLHVTPSVSLATNFTAPRRLRWPTSTRHGTSRCPTAPTARRGLWGIRQGWADPRSRRPTCTCTGPASPPKQRGLLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ1</accession>
    <name>W4TKZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arogenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69202">
        <property type="protein sequence ID" value="GAE69202"/>
        <property type="gene ID" value="JCM18909_2395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7628" checksum="426741F04CF34175" modified="2014-03-19" version="1">MAGTQYTGPLTACSELFVDRTWVVAPRTDNRYDDVQQVVALAQACGARVVSMDAHEHDRAVAEVSHLPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ5</accession>
    <name>W4TKZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69207">
        <property type="protein sequence ID" value="GAE69207"/>
        <property type="gene ID" value="JCM18909_2400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="255" mass="28122" checksum="6BB7E63DDD55419D" modified="2014-03-19" version="1">MTLLVTTTLGLSTLADRFGLDLRDGYHRYPIPVVPPTIRSGFLEGRQLVMPAAVERPHRDEVRSRILAAAAHNFERDGYVGASLRRIAMDAGFTKGAVYSNFGSKPDLFGQVCAARLADGEKDLVDALFPILSSCERPDDLMRSISEKLTEILLEDASWQVILAEFRALARRDDEIAKAYSKLQSQRIAQLAELMTQYGVLDHIKSTDAANPHSLAVVVLSLVNVLALEFSVASAVIDRQVITDVIERAIRGFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL01</accession>
    <name>W4TL01_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69645">
        <property type="protein sequence ID" value="GAE69645"/>
        <property type="gene ID" value="JCM18909_2888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M13_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17363" checksum="9793597D4FEAD579" modified="2014-03-19" version="1">MTASFQDRDSDVRPADDLFRHVNGSWLSTTTIPDDQASTGSFRVLRDNSEAAVHDILEELTSGDAHELRQIASASTDHEVDLMAELYRRFMDSAAVEAAGTTPLTPILARIDRLTTTPEFMTLLGQHYRESLGACFTSLRNPTPPTLLVMCPGWGKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL78</accession>
    <name>W4TL78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sucrose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69730">
        <property type="protein sequence ID" value="GAE69730"/>
        <property type="gene ID" value="JCM18909_2979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="96"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="173" mass="19576" checksum="FC367070EEEBBCF9" modified="2014-03-19" version="1">MVADDSLGHVSLDPSTQQSFDLRWEHYLPDLWIGLSRVYGDRADETLQRIRAILLQRCAERPDDLKRLDEARLLEPDWLQQPTMIGYATYTDHFSGTLKGISDHLDHLCDMGVRYLHLMPLLQPRQGTDDGGYAVADHRTIRTDLGTMDDLADLTATLRAHGISLVMDSSLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA4</accession>
    <name>W4TLA4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69760">
        <property type="protein sequence ID" value="GAE69760"/>
        <property type="gene ID" value="JCM18909_3011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6750" checksum="A27C74BD38F5A0F4" modified="2014-03-19" version="1">MTSITPTPSHSPKAKVATPASGKPTSKARSGTFIAVMGAVVVALCAGVVTFFYGRSRDTTWRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC9</accession>
    <name>W4TLC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68954">
        <property type="protein sequence ID" value="GAE68954"/>
        <property type="gene ID" value="JCM18909_2131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="238" mass="26075" checksum="DDD2D3C98EC69CAF" modified="2014-03-19" version="1">MKGRANRTRLAVVGIIGLVVVAWFMLVRFNVVASWGWRQPKPDAPIVDVPKAWRTDYASWALLIVGILIAVIGLVWLLRQFSSSNRAHTYGMSHEADQGSTVLSTDALGRAVEEQIEEFPGVSSASVRFFGARVAPEMMVQIDIDDRADVRKLVDRLESEVARDVEAALDAKLVRFGTKLRTGAHVTGMGVSHVGVTEVPNIDDSGDSLPANPMPKSTFLQEKSDRAKPRTREGKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE0</accession>
    <name>W4TLE0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69561">
        <property type="protein sequence ID" value="GAE69561"/>
        <property type="gene ID" value="JCM18909_2790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="27574" checksum="78A7DD2C1E3CF3B5" modified="2014-03-19" version="1">MTFTPRMVALDIDGTLVNHQGELPHAVREAVAKINVPAVLATGRGLFGAVSIHEALGLQGGHVVVSNGAVTATMSPLKVQTEITFDPRPIIDHVMDVYPQALIAVEEVGVGYRLNQLFPVGELQGELHIESIEELASRPAPRVIIRDPNGYADSFQDLAHSLDLHSVSYVIGWSAWLDITPEGVTKASALDALCRLKGIDPKDVLAIGDGNNDIEMLQWAGRGVAIGDASEQVQAAADDIAPCFEDGGTANELNRWFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE1</accession>
    <name>W4TLE1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68969">
        <property type="protein sequence ID" value="GAE68969"/>
        <property type="gene ID" value="JCM18909_2147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6344" checksum="2A0AAC2EE5A627DC" modified="2014-03-19" version="1">MDDWGVSAPGCRGRRIRAREPQEEEKKGSDEKSTAHVLFFAERGPPIETVRKFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL1</accession>
    <name>W4TLL1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69323">
        <property type="protein sequence ID" value="GAE69323"/>
        <property type="gene ID" value="JCM18909_2525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19480" checksum="C64C04B9EA9FBE38" modified="2014-03-19" version="1">MFYVGGLGSLYDLRAFCEAVASVPEASLTICTRPKEWEQARKDYEPLTGNNIKVVHANGKKELEPYFAAANVAVLAMAPHEYRDFAAPLKLFEYIGNGKPIIATEGTFVGDVVTRDELGWTVQASVDEFAALLEQLTQHPERVDAARDRVMAARDQHTWAARVEELVTALAAVDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN1</accession>
    <name>W4TLN1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription-repair coupling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69079">
        <property type="protein sequence ID" value="GAE69079"/>
        <property type="gene ID" value="JCM18909_2263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrB_inter" evidence="1">
        <location>
            <begin position="161"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="23943" checksum="F82F7F9AF9461F0C" modified="2014-03-19" version="1">MMVSVGTTTYPMLVTFGGLTSLLSREPVLSHVVEDALTRRTPTLDLQVAASARPAVAALLGRSLDGSGRLPVLLVTSTFREAEESVATLKTWLGADAVCYYPSWETLPHERLSPRTDTVGRRMEVLRRLCGTEGEVPQVVVAPVRSLLQPQVAGLGRIAPVRLAVGEEHDLTELATELVNAAYSRVDMVERRGEFAVRGGIVDVFPPVLEHPVRIDFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN4</accession>
    <name>W4TLN4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">JCM18909_2906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TLN4"/>
    <dbReference type="EnsemblBacteria" id="GAE69661">
        <property type="protein sequence ID" value="GAE69661"/>
        <property type="gene ID" value="JCM18909_2906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6707" checksum="5B17142A10D5A001" modified="2014-03-19" version="1">MAKKSGDVRPKITLACTECKERNYITKKNRRNNPDRMEMAKFCPRCRKHTAHRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS7</accession>
    <name>W4TLS7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69706">
        <property type="protein sequence ID" value="GAE69706"/>
        <property type="gene ID" value="JCM18909_2955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10817" checksum="01851CAA1EF9A1DA" modified="2014-03-19" version="1">MTPCRHSPHLDPVVEVLDAAASEVARPKPRCHGELSGTKRCCATAYDDALTRWIPQLQQPPVTSTTSSTVKDSKACDVVYPSWTPLRPPKNLQMSLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM35</accession>
    <name>W4TM35_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70040">
        <property type="protein sequence ID" value="GAE70040"/>
        <property type="gene ID" value="JCM18909_3322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17497" checksum="6F1E543C4F0F6C23" modified="2014-03-19" version="1">MKKATLVDFASAKSYGTGALLQRIEAGASAGRQMVCDFWLRALREVLPDIIFGLWFISRMDFRIALAVLLGYVVLLATTNLMLRRLYALKRDAVVDDELINRSISRIIMEFVSVRILGLGSRELAKTRRLCSENTNRSAKVVATHEFFSSPSLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM90</accession>
    <name>W4TM90_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69309">
        <property type="protein sequence ID" value="GAE69309"/>
        <property type="gene ID" value="JCM18909_2510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="193" mass="20401" checksum="F8D49D12F347A38A" modified="2014-03-19" version="1">MDLGLNGRTALITGADSGIGWHTAKLLLAEGANVAITDLDSDELTQAAQALDVADDRLVALPADVTDADSLAKLHQQVKDALGPIDILVQSAGVTGAQGKFHEIDEEGWRSTLDIDLMGPVRVLREFLDDLRTGGWGRVVLLASEDGVQPYDDEIPYCAAKAGVLALAKGLSRTYAREGLLVNAVSPASFIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC5</accession>
    <name>W4TMC5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70135">
        <property type="protein sequence ID" value="GAE70135"/>
        <property type="gene ID" value="JCM18909_3431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12127" checksum="3923469093E2F3B8" modified="2014-03-19" version="1">MLPAPVPVSVAWQPGPAKITGSAVEEITRAFIAAGLSKIVAWDNLASAVSTSVIMVTRCRPDLRQAAIDVATEILAMVDPRPGITAGPGFHRRSCCLYYQVSGSRIACCVDCVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMP8</accession>
    <name>W4TMP8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YCII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YciI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70260">
        <property type="protein sequence ID" value="GAE70260"/>
        <property type="gene ID" value="JCM18909_3563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII" evidence="2">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10369" checksum="E6AABE45C48149EB" modified="2014-03-19" version="1">MAVFIVETHYDPAHSEERMAARPAHLENLDVMRERGQLANAGPLADGSGAVLIYTMPDRDVLNHLLEADPYPKTAVQVTSVREWKPNYHHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS5</accession>
    <name>W4TMS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70285">
        <property type="protein sequence ID" value="GAE70285"/>
        <property type="gene ID" value="JCM18909_3593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="182" mass="19435" checksum="26E917AE8659AF32" modified="2014-03-19" version="1">MQIGGKHTRRRIGRVVEIGIDGHLAPDLGVLKRFRLPTDMDGVKDLGFGREVTVRVHPDLPVDIELSGGSLRASGVERFGRVRVTAGVTEIDGVHQIEDGLFQAGRGSITGRIDTGRSQIRVESGNLNIKLAGGSNVSVRGKAQTGMISWPEGGEVDEYVMGNGSARLDLTCLVGRIAVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT7</accession>
    <name>W4TMT7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70295">
        <property type="protein sequence ID" value="GAE70295"/>
        <property type="gene ID" value="JCM18909_3603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025339">
        <property type="entry name" value="DUF4245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14030">
        <property type="entry name" value="DUF4245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13670" checksum="FD1F4A737AB6B3C8" modified="2014-03-19" version="1">MLAPKEVPEDWRPTKARYANKEDRWVGNTISAGNRWELGFLTSKNIYLAVDQSDEPGRAFVASVTRSAIEDGKVSVGRYTWTKMVSPDDRTHALVTKIGSATAVIVADTDYRGLTDFAGMLTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY2</accession>
    <name>W4TMY2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-isopropylmalate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69897">
        <property type="protein sequence ID" value="GAE69897"/>
        <property type="gene ID" value="JCM18909_3163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="15681" checksum="E851716DF102F234" modified="2014-03-19" version="1">MASDRRRSCQEFPSVTTDYLHVDAVTIALVRNPQRFDVIVTDNLFGDIITDLAAAVTGGIGLAPSANINTSGEFPSMFKPVHGSAPDIAGTGKADPTAAILSIAVLLDHLNRPEDAARVREAVSADIATRASGPARTTSEIGRDIAQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN83</accession>
    <name>W4TN83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70196">
        <property type="protein sequence ID" value="GAE70196"/>
        <property type="gene ID" value="JCM18909_3494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase-rel" evidence="8">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17622" checksum="F2464DBE94E42300" modified="2014-03-19" version="1">MSPDRMLLGRVFAYNDAARNRLGVNYEQLSVNRPTTPINQYTFDGQMAFEHSGSAPTYAPNSYGRDFATGYRTGSEATWEADGELVCSAQTRHAEDDDFGQAHTLVHDVFSDAERDELVDTLVDLMTNFDMEEPVIGNTLSYWRNIDAGVAEAIEGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN91</accession>
    <name>W4TN91_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69684">
        <property type="protein sequence ID" value="GAE69684"/>
        <property type="gene ID" value="JCM18909_2929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb1_5" evidence="7">
        <location>
            <begin position="33"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="503" mass="54090" checksum="A9D070D8B27B8DE6" modified="2014-03-19" version="1">MTQMRQIAAMRGLVADPKGDIIPRPIKSNFREGLTVLEYFISTHGGRKGQADTALRTADSGYLTRRLVDVSQDVIVRENDCGTTRGMPKTIAVDDGNGNLVRVEGLDTAVYARCLAADALDANGNVVVEANSDLGDEEISRLIAAGISQIKVRSVLTCTAAQGCCARCYGRSLSTGHLVDVGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRVVELFEARSPKGKSPLAEAAGVIRIDESDNRRKLVLVRDDGEDDVEYVVPRRARLEFDLDGTHRVIRDGVRVAAGEQLMGGTADPQDVLRISGVRRVQEYLVKEVQKVYNTQGAGIHEKHIEIVIRQMLRRITVIESGDTQMMPGELVDRGAYEAANRKAVAEGGRPAEGRPVLMGITKASLATESWLSAASFQETTKVLTDAAINGKTDTLVGLKENVILGKLIPAGTGLEVYRNMRVEPTAEAKAAAFTMNYDPFDYDFGSGSGEAVPLDDLDLGDLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB2</accession>
    <name>W4TNB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70017">
        <property type="protein sequence ID" value="GAE70017"/>
        <property type="gene ID" value="JCM18909_3297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6426" checksum="26814510DC905D7E" modified="2014-03-19" version="1">MEFRTRDGVAKAINGTSFTLSERETLAILGESGSGKSVTAQALWASSSPLQPRSLAGGLSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND6</accession>
    <name>W4TND6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70047">
        <property type="protein sequence ID" value="GAE70047"/>
        <property type="gene ID" value="JCM18909_3331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7443" checksum="7566D291CA44C171" modified="2014-03-19" version="1">MGSSHLGEDSPDDHEYHDFHDDEKFKILMVVGSSNTTKETTPQRKKHSTYTVYTTLPNRTRFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNE8</accession>
    <name>W4TNE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribose ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70062">
        <property type="protein sequence ID" value="GAE70062"/>
        <property type="gene ID" value="JCM18909_3347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11910" checksum="12D9F97440A8C0BD" modified="2014-03-19" version="1">MTTVLRLDHVTKVFGPVKVIQDVSVDVIPGRVRVLLGENGAGKSTLIKMMSGIYHPDSGSVIIDNIPVELPTVKAAEARGIATIHQELNLVPQMSVAENIMLGRTPSRGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG3</accession>
    <name>W4TNG3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69923">
        <property type="protein sequence ID" value="GAE69923"/>
        <property type="gene ID" value="JCM18909_3191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7304" checksum="44D20289F941F5A3" modified="2014-03-19" version="1">MRHDEKITVYVSTEELIALETARLTMRSQGINADRGRIVRASVAMALADFEENGEDSALAHLLTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH6</accession>
    <name>W4TNH6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70092">
        <property type="protein sequence ID" value="GAE70092"/>
        <property type="gene ID" value="JCM18909_3382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="5">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="791" mass="87289" checksum="A5A12089AA09A65E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI8</accession>
    <name>W4TNI8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpC</name>
        <name evidence="11" type="ORF">JCM18909_3226</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TNI8"/>
    <dbReference type="EnsemblBacteria" id="GAE69953">
        <property type="protein sequence ID" value="GAE69953"/>
        <property type="gene ID" value="JCM18909_3226"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16030" checksum="624210FFA4740A7D" modified="2014-03-19" version="1">MDHPPLQVKVVSADREVWKGESVNIIVRTTEGDIGLLPGHEAFLAALAPCAAQIITTDGNREVIACDGGFVALDNDGQVSIITQYATRSEEISVDQARRDRDSLRKKLNEHERSEQDPEVVQDLTHRLHLAQAQIAAARLAGKQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK5</accession>
    <name>W4TNK5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ORF">JCM18909_3416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70122">
        <property type="protein sequence ID" value="GAE70122"/>
        <property type="gene ID" value="JCM18909_3416"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17422" checksum="7C58CCB8F622FD46" modified="2014-03-19" version="1">MGAHILNSIALESLIPEGCHVADVGSGAGLPGIPLAILRPDLEMTLIEPMLRRSNFLTEALDELGLDDRVTVVRGRAEDADLHVDVVVSRAVAKLATLINWTADLIVDSGSLLALKGQSADDEVVKAKKELSKRRLFAEVLLIRADPTSDVTRAVRVRRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK6</accession>
    <name>W4TNK6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription termination factor Rho</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69973">
        <property type="protein sequence ID" value="GAE69973"/>
        <property type="gene ID" value="JCM18909_3249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="7274" checksum="B33C9F369672324C" modified="2014-03-19" version="1">MKKFAPLVKIEQVNGVDPEQMKQRPEFSKLTPLYPQERLRLEDDPKKHDWADHRSRQSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK8</accession>
    <name>W4TNK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69794">
        <property type="protein sequence ID" value="GAE69794"/>
        <property type="gene ID" value="JCM18909_3049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="203"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="462" mass="49863" checksum="25E364CA19364F75" modified="2014-03-19" version="1">MKLTILGGGGFRVPLVFKALARDTSPQRVTELRLYDTDPLRLGVIETVVAQLTPALPHAPSVVATTDLPTALAGTDFIFSAIRVAGTHGRALDESMCLARGVIGQETVGAGGISYALRGIPVVLDLVEQITRYAPDAKVINFTNPAGVMTEVMQRRLGDQVVGICDSPVGLARRILTTLQGAGLAPADLGSLFDGDGRIHIGYSGLNHLGWLTSLNVDGVDVLPHLLERPDLIESFEEGRLFGADLVQALGAVPNEYLHYYYYSRDDLAVDRKAEAPRGAFLEAQQNQFYTQAQHTDDVAGLWEATRLEREETYMATNREVSGEFERDEADLETGGYDKVALAIMHAIANDVPAELILNVANHGALPDLPDEAVVEVPCRVDGAGIHRLPTPALPDHARGLVVNAKYVEQRTIDAAVNHSRTAALLALSHHPLVDSVHVAEQLLDDFADAFDGLEYLKDAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNQ2</accession>
    <name>W4TNQ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70167">
        <property type="protein sequence ID" value="GAE70167"/>
        <property type="gene ID" value="JCM18909_3463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="132" mass="14106" checksum="4AF505516633A3DF" modified="2014-03-19" version="1">MEPEPPQMPFAWWTVCLTLVIIAAGITASVSASLGHIARNQSRQLLAIGLPKRLGAMIPILESMLLVGLCSVIASVLAIVPVVVGRSLSESFTLWVPKDWVILWCAGLGLLIVLSPLAGLRAIRARERTADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNS5</accession>
    <name>W4TNS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70615">
        <property type="protein sequence ID" value="GAE70615"/>
        <property type="gene ID" value="JCM18909_3969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="315" mass="32973" checksum="A9CC4E22CBB1B780" modified="2014-03-19" version="1">MIARRTILASGAAFVTIGLTGCGHNSPEKKTTPVRATTTASAPHRSDAVSTEALLADLATKAARSATDGQRTVLNQVAAAHRRHLEVLSQSNPFSGSTATPSAAISPTPRTAGQGSPLALLQHHEKAAATQYLEICQTAQDSSETLLWASLSVFCSAFNPSAPAPQPTPKVVPVTVGQEPLTNAQQALLTHLSALVAGLEWGIGRLGENDPLRTWGWDRREQVLAQRAEVRQSIRDASTTPTPDVPGYPMSPAPVNDAATRSLWSGLEVNVLSGWGRVTAASGSAARPHAVASMVSQTQVLAHLGTGVTTWPGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP77</accession>
    <name>W4TP77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70332">
        <property type="protein sequence ID" value="GAE70332"/>
        <property type="gene ID" value="JCM18909_3646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="15670" checksum="E32726614FB13869" modified="2014-03-19" version="1">MKGNFHSTYDQGFARVAACTTTVHIGDPASNVAGILDTCRELDSRSVAIAVFPELCLTGYAIDDLLLQDVVLDAVLDAIETVRQASRSLFPVIIVGAPLQRGNRLYNCAVVIHRGQVLGVVPKSHLPNYRESTKNVISPSARALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP93</accession>
    <name>W4TP93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA double-strand break repair Rad50 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70347">
        <property type="protein sequence ID" value="GAE70347"/>
        <property type="gene ID" value="JCM18909_3661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14602" checksum="30651B108AC61419" modified="2014-03-19" version="1">MTSLEQAESRLAERKVMETHISSWREHLEEEQGKVTIQELEAMAERTTETVSVTAAEAQKLEEEAVAAANEARTAQRQADNRLRTVEERHIELMRRSSGQISTPKKNRRNGRQALYRTDGCTQNHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPB9</accession>
    <name>W4TPB9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70372">
        <property type="protein sequence ID" value="GAE70372"/>
        <property type="gene ID" value="JCM18909_3688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="14208" checksum="163A4D8CA4094CE1" modified="2014-03-19" version="1">MEDMTIFRAVNIRDDLKKGPAEGYRVLVDRMWPRGVKKDDARLDERRTDLAPSSQLRTWWNHDPERFDEFAGRYEAELDESGAAKTFLEESAGRDEVILLYGAGDREVNHAIVLERILTELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM8</accession>
    <name>W4TPM8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="9">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_3794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="9"/>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70467">
        <property type="protein sequence ID" value="GAE70467"/>
        <property type="gene ID" value="JCM18909_3794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE70467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20855" checksum="591FCF5C2C709391" modified="2014-03-19" version="1">MIRTLFFDVHIKRLHEYKRQLLNAFYVLDLYFRIKDDPSLNVPKRVFVFGAKAAPGYIRAKAIIKFINEVARLVNNDEDINGRIKVVFIHNYNVSPAEHIIPAADVSEQISMAGKEASGTSNMKFMMNGALTLGTLDGANVEILDAVGDDNATFFLVPLRSSCLPSSGTTIRGGITRMYRASSGSLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPZ2</accession>
    <name>W4TPZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70299">
        <property type="protein sequence ID" value="GAE70299"/>
        <property type="gene ID" value="JCM18909_3607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11640" checksum="0AD56AF0A9183890" modified="2014-03-19" version="1">MFAAFTDKPDLTPYQAASPSYDMKTLNTPKTPMAKESGEQDTTKEDDIDEQVFNKAIWKAVKGARSTMLEPKHSVIQSGPVLTYDDDDDESEKNSSLETSTWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ90</accession>
    <name>W4TQ90_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000052">
        <property type="protein sequence ID" value="GAE70558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70558">
        <property type="protein sequence ID" value="GAE70558"/>
        <property type="gene ID" value="JCM18909_3900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022291">
        <property type="entry name" value="Bacteriocin_synth_cyclodeHase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03882">
        <property type="entry name" value="cyclo_dehyd_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="575" mass="62658" checksum="BEB58CB99E31D92B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ94</accession>
    <name>W4TQ94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70563">
        <property type="protein sequence ID" value="GAE70563"/>
        <property type="gene ID" value="JCM18909_3908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19241" checksum="E4FBA7FBA406CB29" modified="2014-03-19" version="1">MGAGSCLLSSMLVDTVAAPLPGQMLAWGLTGLIGTLLVRVPTKLAWLLSWPLAVLCGPVLGVMLNLIGWPTEGVSTVGQTTSDAFIPGLPAMITIQRLIRYSVRTSLGIDLTRGVCTLVGVVLVGLPAISALRTAWGRPDRRADEAPTARGTPINPAAVERRQQSRTRTMEWSKDQKEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR24</accession>
    <name>W4TR24_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000069">
        <property type="protein sequence ID" value="GAE70699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70699">
        <property type="protein sequence ID" value="GAE70699"/>
        <property type="gene ID" value="JCM18909_4079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7720" checksum="CCC0C1D91ACA112E" modified="2014-03-19" version="1">MPQVRYLIFSIPRENKDEITGSLYVDISDYTNRTILNGWSWAFSHEPFELKWWHHIVPKTWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR43</accession>
    <name>W4TR43_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Abortive infection bacteriophage resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000088">
        <property type="protein sequence ID" value="GAE70719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70719">
        <property type="protein sequence ID" value="GAE70719"/>
        <property type="gene ID" value="JCM18909_4105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6487" checksum="C41AA66CE7CDDC42" modified="2014-03-19" version="1">MFGQLSLIQYLHRQLDLSPADRLPKLFHTYPHNPIVPFSRTGAPDNWRELPLWCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDG3</accession>
    <name>W4TDG3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein BluB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_14</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66985">
        <property type="protein sequence ID" value="GAE66985"/>
        <property type="gene ID" value="JCM18909_14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012825">
        <property type="entry name" value="BluB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02476">
        <property type="entry name" value="BluB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE66985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="333" mass="36600" checksum="6444EF2CEACAB8AB" modified="2014-03-19" version="1">MIIPDENPSTSRRWNRPIPRIGDTTSSATRAADPTGWSLGDQVQQGLDTAIDTRRDIRRYRHDDVSKELVNTVLWAGHRAPSVGHSQPWRFIVVRDGDIRDRAAVMADRERLRQADLLTPGRRAHLLDLQLEGIREAPVGIVVACDRRAPASGVLGRNTFTDADMWSCACAVENMWLTARAHGLGMGWVTLFQPEELAELLHLPNDVETLGWLCLGWPDERPPAPGLERRGWSRRVPLSDVTLADRWPADSAQPEAPVSALRQTLHSPNRYQVVAAHDDADQLLTPPGSLGLLDQTLDRVEAAGGTEITGGTLVLVGADHPVAHLGVTAFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDZ2</accession>
    <name>W4TDZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67180">
        <property type="protein sequence ID" value="GAE67180"/>
        <property type="gene ID" value="JCM18909_222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7159" checksum="86374DD2E81942B7" modified="2014-03-19" version="1">MLEHFRAGWAKVMNPIADALLRAHVTPDVVTWIGTIGAVLMALICFPQLAVAGAMVGYSVYLLRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE82</accession>
    <name>W4TE82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonucleotide reductase transcriptional regulator NrdR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67091">
        <property type="protein sequence ID" value="GAE67091"/>
        <property type="gene ID" value="JCM18909_127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7251" checksum="8369794C30FC6B47" modified="2014-03-19" version="1">MAILGPLRELDPIAYLRFASVYLNYNTIEDFATEIDRLRDESSDKTKSSSRKRLLKQDEPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEN4</accession>
    <name>W4TEN4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="13" type="ORF">JCM18909_301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67256">
        <property type="protein sequence ID" value="GAE67256"/>
        <property type="gene ID" value="JCM18909_301"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="61"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE67256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="423" mass="45874" checksum="D22EAFD4D990E441" modified="2014-03-19" version="1">MERTIMSARDLPDARGHFDRFGGRFVPEALQAALNQLTETFEAAVTDPDFLTELEDLRREYAGRPSPLTEAPRFSQYIFQQTGHQVRVLLKREDLNHTGSHKINNVLGQALLTRKMGKRRLIAETGAGQHGVATATVAAMMGMECRIYMGQVDTERQALNVARMQLLGAEVIAVEAGSRTLKDAMNEAMRDWVAHVEDTHYLIGTASGPHPFPKLVREFQRVISAEARQQCLDRVGRLPDAMCACVGGGSNAIGSFAEFIDDPEVRLYGFEAGGDGVETGRHAASITGGSVGVLHGTRTYILQDPDGQTMESHSISAGLDYPGVGPEHSWLAAQKRAIYLPVNDREAMEALRTLTRTEDIMPAIESAHAVAGVLKIAKDLPAHDGEPPVAIVTVSGRGDKDVDTALKWFAMDGSVDATTGGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEN8</accession>
    <name>W4TEN8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 5">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 5"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67410">
        <property type="protein sequence ID" value="GAE67410"/>
        <property type="gene ID" value="JCM18909_468"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_N" evidence="10">
        <location>
            <begin position="46"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="UDPG_MGDP_dh" evidence="9">
        <location>
            <begin position="236"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="286"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="349" mass="38015" checksum="842E787A54BC2071" modified="2014-03-19" version="1">MIVAGLTLDGEPCNEVLPEAEKKVTGVVRHTAALNSWGPPKGPPVKIAVAGLGYVGMANAVLLAQHNSVVAIDIDAERVDMVNNRHTTIVDPLIAEYLAHHNLDLRATTDPQEAYRGADFVVIATPTNYDPDQNYFDTSSVDEVLDLVQELAPHTTTVIKSTIPVGFVEGVRKERPGLDVIFSPEFLREGKALFDNLHPSRIIVGADSPKAHLFADLMAAGAIDTNVPVLFVGATEAEAIKLFANTYLAMRVSFFNELDTYASQRGLSTRQVIDGVCLDPRIGDHYNNPSFGYGGYCLPKDTRQLLANYQDVPQTLIQAIVDSNTVRKDFIASDIIARDRNGWGSSVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF42</accession>
    <name>W4TF42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67580">
        <property type="protein sequence ID" value="GAE67580"/>
        <property type="gene ID" value="JCM18909_651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850718" evidence="2">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10378" checksum="977F7270E4B96F4B" modified="2014-03-19" version="1">MRRTATTRVTAAVMRTTRSGLLVRLMAIPQPAAQAHHDHGWTVLVLLGAAATGISMTGSAVLVTNLDTVQRRFQSLSASLPSSTILVYDQVRHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFH6</accession>
    <name>W4TFH6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67720">
        <property type="protein sequence ID" value="GAE67720"/>
        <property type="gene ID" value="JCM18909_799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="3">
        <location>
            <begin position="15"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="351" mass="39068" checksum="C9710039303D7B77" modified="2014-03-19" version="1">MSATDRVNLMCANVLAAVAWPYANGPRHIGHVSGFGVPSDVFARYMRMSGHRVLMVSGSDCHGTAISVKADQEGVTAQECAEKYHRIIAADLQGLGLSYDLYTSTLTDNHAHVTQEIFTRLHENGYVVKRSEMGAFEPSTGRTLPDRYIEGTCPVCGYDDARGDQCDNCGRQLDPADLIDPRSKTTGAAPEFRETEHFFLDLPALAESLASWIGTRTDWRPNVLKFSHNLLEELRPRAITRDLDWGIRVPVEGWQDNPMKSIYVWFDAVIGYLSASIEWRAVLVGLMRGVSSGMTRMPVHTTSWVRTTLCSTRSFGPASCWVQMDVVIRVASHPRNLEPSTFPPRLFPASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT7</accession>
    <name>W4TFT7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="6" type="ORF">JCM18909_344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67298">
        <property type="protein sequence ID" value="GAE67298"/>
        <property type="gene ID" value="JCM18909_344"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="5">
        <location>
            <begin position="47"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="388" mass="42555" checksum="03C43ABA08FD57A3" modified="2014-03-19" version="1">MTQHRQTSHPRPVANPEPNSIQLADLPLRSELVGAQPYGAPQLDVPVRLNVNENPYPPSEAVRKDMAKAVAKVAKSLNRYPDREATGLREDLARYIGFGISSSQIWPANGSNEVMTHILQAFGGPGRSMLTFTPTYSMYPEYARNTHTNYVTRPRNASWGLTTDEILSAIEEVKPDVVLLTTPNNPTGTTIPVAVIDEVCAGTDTIVVVDEAYQEFTDAPEDSSIALLPKYGRLIVVRTLSKAFALAGGRLGYAVAAPAVVDALRMVRLPYHLSEVSQVVARVALAHAPEMLARVDELRETRANLEDWLQLHGLDVVSSQSNFVLFGRFADRHSVFQALLDRGVLIREVGPTGYLRVCAGTPRQTDAFRTALLDVLPTAPRLVPEEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG25</accession>
    <name>W4TG25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67094">
        <property type="protein sequence ID" value="GAE67094"/>
        <property type="gene ID" value="JCM18909_130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14195" checksum="D745517A4FF1CB71" modified="2014-03-19" version="1">MQYDDTINAWHTTPNSGRINASNPCSEYMSLDNSSCNLASLNLLKFLDENDHFDVEKFTRAVELVITAMDISICFADFPTEAIGKTTRNFRQLGIGYANLGASLWRWAWVTTRMVDVPSQLPSRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG64</accession>
    <name>W4TG64_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neopullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67408">
        <property type="protein sequence ID" value="GAE67408"/>
        <property type="gene ID" value="JCM18909_466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17503" checksum="F195442BB925E73B" modified="2014-03-19" version="1">MGRHNEFSDAFTPMTFVGNHDVTRIASRVGQDGAVLATAILATIGGIPLIYYGDELAYRGVKEERFGGDDDIRPVFPANPADLSNPGADTLRAHQNLLGLRRRHPWLVDARTESLDLTNERYVYRTGVPGVEPLIVELDVRDGCSVLIREAGQVVWSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG65</accession>
    <name>W4TG65_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamine synthetase</fullName>
            <ecNumber evidence="7">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67522">
        <property type="protein sequence ID" value="GAE67522"/>
        <property type="gene ID" value="JCM18909_587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="8">
        <location>
            <begin position="104"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="4">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="473" mass="53209" checksum="440C3F68C9CD42FC" modified="2014-03-19" version="1">MFEGPDDLLAYVKKEGIEMIDVRFCDLIGIMQHFTVPAREFDKDQYENGLAFDGSSIRGFQKINESDMALLPDPTTAWVDPFRERKTLIVNFNVHDPITKEAYSRDPRNIARKAEAYLASTGIGDTAFFAPEAEFYVFDDIRFDTRQNTSYYSIDSEAGAWNTGRTEDGGNRGYKVKYKGGYFPVAPTDHFGDLRDEIVTIMESLDMKVERAHHEVGTAGQAEINWRFDTLSRSADDVMKFKYIVKNVAWQHGKTATFMPKPIFGDNGSGMHVHSSIWKGGEPLFFDESGYAQLSDMARYYIGGILKHAPSLLAFTNPSANSYHRLVPGFEAPVNLVYSQRNRSACMRIPITGPNPKAKRVEFRCPDPSANPYMAFAALLLAGLDGIQNKIEPPAPVDKDIYELPPEEHAAMDHVPGSLGAVLDNLEADHEFLLAGDVFTPDLIETWVELKRGDLAALQQRPHPYEFDLYYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA7</accession>
    <name>W4TGA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67443">
        <property type="protein sequence ID" value="GAE67443"/>
        <property type="gene ID" value="JCM18909_504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12213" checksum="709D02BE03EA383F" modified="2014-03-19" version="1">MITRDERTWLLDAVARDAHEWDEWFGRSIDIGGLEKERNILRYRPAPTQVRGCADAKLVDVARVVAAGLLAAGDDISVCLDRALTKGWAERCVRSVWPLPLLATRTGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB7</accession>
    <name>W4TGB7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67577">
        <property type="protein sequence ID" value="GAE67577"/>
        <property type="gene ID" value="JCM18909_648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="13587" checksum="E196B19E5BFC5D8B" modified="2014-03-19" version="1">MSEGQRLALVLAIQLSSRPDVVLLDEPTRGLDYAMKTELTRIVKGIAAGATGDPAAVLLATHDVEFAATTTDRTIVMATGHIVADGSTRSVCTSSPGFSPQIAKVFHPADVMTIADVERLVNTPAGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT3</accession>
    <name>W4TGT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium and cobalt transport protein CorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67742">
        <property type="protein sequence ID" value="GAE67742"/>
        <property type="gene ID" value="JCM18909_823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="331" mass="37516" checksum="C551B2B977B254AE" modified="2014-03-19" version="1">MSLSQLSSRVWQYGKVIAESVPLETLNEELSDTRTLSWYDLTAPDREDIDILADELNLDFHTVEDAEAPGERPKVTRYPDHLFLTTYAATIGETGDPNSRLIVSRVSVWVFEHGVVSVHRNDLPEIAEVLNRLDANPDLVSNGPMGIVHAILDVLVDGHFDTVQHLDDVVEDVEDQLFDDSIDIQQVQLRVYRLRKELVQFRRIVLPMREIVSTISRPSREAVAVPRVLEPYFNDLYDHSMRVSEWSDSLRDLVATIFETNLSIQDAKLNIVMKKLAGWAAIIAVPTFVTGWFGQNVLLGDGRPLGLWISAVLVVASSVLLYLVFRREDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU7</accession>
    <name>W4TGU7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JCM18909_1312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M01.012"/>
    <dbReference type="EnsemblBacteria" id="GAE68190">
        <property type="protein sequence ID" value="GAE68190"/>
        <property type="gene ID" value="JCM18909_1312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012778">
        <property type="entry name" value="Pept_M1_aminopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02412">
        <property type="entry name" value="pepN_strep_liv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="163"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="294"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE68190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="430" mass="49317" checksum="1E809B3A9FA5F919" modified="2014-03-19" version="1">MTAQRNRWISCPDTAPWLPARTRQERTPDTPVEPGRSFTGRNCSVWMLMHAPLPYSGGVSSMNLTREEARHRSEIIKVERYHVRIDVRGADADGATHFTSNTRVRFSTTEPDTFLDLLDGEIESVIVNDEDIEPEYDGSRIQLDGLHTHRENLVIVTAKLPYQHTGQGLHRFVDPADGKVYLYTHFEAADSRRMYSVFEQPDLKAHVDFDVIAPSDWRVASNQVHEDIREEEDGLLHDFALTPRMSTYLTAIAAGPYVRFQDEWHSRDGSESIPLGILARASLAEYVDHEEIFKITKQGLAFYHRTFGYPYPWGKYDQIFVPEYNLGAMENPGLVTFTENYIHRGPATRSELAGRTNTILHEMAHMWFGDLVTPKWWDDLWLKESFAEYMGAHASVAGTEYREAWTNFAVGRKAWAYTADQQSTTPPDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX4</accession>
    <name>W4TGX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arginine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67394">
        <property type="protein sequence ID" value="GAE67394"/>
        <property type="gene ID" value="JCM18909_451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14248" checksum="4B35BDA4784AAE76" modified="2014-03-19" version="1">MRERGIAVHEMHQLLSEVLDIPEGRSWVLDRKLSPNAVGLGVDEDVRDWLNDMPSDTLAEYLIGGVAYGEVPADRRKHVLGALIKAHSENEFLIPPLPNTQFTRDTTAWIFGGVTFNNALAGSSAGNRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ1</accession>
    <name>W4TGZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-acylating propionaldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67698">
        <property type="protein sequence ID" value="GAE67698"/>
        <property type="gene ID" value="JCM18909_776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07121">
        <property type="entry name" value="ALDH_EutE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012408">
        <property type="entry name" value="Acetald_propionald_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036410">
        <property type="entry name" value="EutE_PduP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="18"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="470" mass="49907" checksum="ED20D72B2E3AB81E" modified="2014-03-19" version="1">MTTTAVPPTSTQLCGVFADVNAAVTAAREAFLAFSDCSLAQRRTFINAVREAASQQERLEYMATAAVEETGMGNVHHKVLKNLYAATRTPGVEDLVMEARQGDDGLTTLEYSPYGVIGAITPTTNPTETIICNTVGMLAAGNTVVFSPHPRARHLSAWLVDVLNRAMVEAGAPDNLITVITEPTPDTTKALINHPDITMLVATGGPQIVNMVLSSGKKAIGAGSGNPPAVVDETADVAKAASDIVQGASFDNNLPCTAEKEVIVVAEVLPQLMTAMTANGAQVVSDPEELAKLRSLLLDPSGTRPNTAWVGQDAQKILRAAGIEPHQDTRLVTMVTDPSDPFVQVEMLMPVVPVVPVTDYLTAIDLAVELEHGNRHTAIMHSKDVSRLDLMARRIQTTIFVKNGPSFAGIGINGEGFATFTIAGPTGEGLTSARSFARRRRCVLDAHQVLRPGQDPARCPTHATSEASHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB0</accession>
    <name>W4THB0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67529">
        <property type="protein sequence ID" value="GAE67529"/>
        <property type="gene ID" value="JCM18909_594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15555" checksum="8763B1EEC20E677A" modified="2014-03-19" version="1">MTVRDYLVELIDTRLSVGDVVPSERELAERFGISRMTVRQAVDSLVSSGMLERRRGSGTYVRAPKVDVQSRISSFSEEMRQRGMIPGTRYCVVKSCRPLLMSLCGWGSSRGSQSITSTVCGWLMAFRWRLRRPGSLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB2</accession>
    <name>W4THB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68350">
        <property type="protein sequence ID" value="GAE68350"/>
        <property type="gene ID" value="JCM18909_1479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10282" checksum="EDCB6B0167CF8A2E" modified="2014-03-19" version="1">MALPDAPTLLEFRDVTFSYPGASEPVLHDISFTLARGTTTAIIGSTGSGKSTLVNLIPSSSTSLTDRCSSTEPTCAVTTLKPYGAASVWCPSGPTSSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI2</accession>
    <name>W4THI2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67957">
        <property type="protein sequence ID" value="GAE67957"/>
        <property type="gene ID" value="JCM18909_1059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12434" checksum="5FDF8A8F5D3FE5AB" modified="2014-03-19" version="1">MLLTIVAAGIADVVVVWSCALVYDTRLGAALLGCLGALVLSHVWASRRALATAWWSCGLVLLCVVGMAVYAWVRAGLSPVDPVVVETLAPILPVAACTAVGTGYVWRLCARLVADHCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR9</accession>
    <name>W4THR9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68062">
        <property type="protein sequence ID" value="GAE68062"/>
        <property type="gene ID" value="JCM18909_1174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="165" mass="18339" checksum="C3D5BE079361C34C" modified="2014-03-19" version="1">MTRRAENSEYRAHVGYVPQECSWSPSWSVEEFLAFCARMYRVSAACMRQRCRNVISDLNVEQFAHQLIGTLSGGQKCRVFLAAALVHDPEVLILDEPTVGLDPAERIAFRRHVVNQAASRVVVLSTHLMDDVALAADHVHLVDAGCITWSGSLPELMAEAGQFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU8</accession>
    <name>W4THU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67998">
        <property type="protein sequence ID" value="GAE67998"/>
        <property type="gene ID" value="JCM18909_1103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16583" checksum="2DB5B271CA9E7B23" modified="2014-03-19" version="1">MMFGLPGACLAMWRCVPKGRRAKYTGLFASVAFTSFLTGITEPIEYMFLFVAPLLYVFHSVLDGVSFLVADLINIRIGNTFSGGAIDYLLFGVLQGEAKTHWLYVLPVGALWFVIYYFSFTFFHQEIPDRHPGTSRGHHDCRHTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV4</accession>
    <name>W4THV4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68520">
        <property type="protein sequence ID" value="GAE68520"/>
        <property type="gene ID" value="JCM18909_1664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21620" checksum="C793004EF57E9E6C" modified="2014-03-19" version="1">MSFEDPADSYRGPYDSGSYEMDKLPHLSAASFLGGRYRLDQEISRLEPSLTWRAFDTKLHRPVLIYALAPHGRRTPAVLDAARRAAVATDSRFLRVLDAVVAGPGEPASWVVSEYAPGKSIEELLETGPLSALEAAWIAHEIADAMAPLHAQGIFHDRISPGTVLVTSTGNLKISGLLIEAALHPGRGIVLALGRTAKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW4</accession>
    <name>W4THW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68371">
        <property type="protein sequence ID" value="GAE68371"/>
        <property type="gene ID" value="JCM18909_1500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022128">
        <property type="entry name" value="FhaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042287">
        <property type="entry name" value="FhaA_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12401">
        <property type="entry name" value="DUF3662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3662" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17417" checksum="0E06803B337B3219" modified="2014-03-19" version="1">MGFLDKVEKSIEGAVSGVFARAFRGEVEPVEIAGRLQRELDSEAQILSRDKSLVPNDFVVRLSSRDYERLVPYTKTLNAEIIPTLRDHASERHYVFNGPIHIRYDLDDALPVGKLTVLTGENHAKAVSDRRAPLVLEVDGVRHPLTSGTDDWPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY4</accession>
    <name>W4THY4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68132">
        <property type="protein sequence ID" value="GAE68132"/>
        <property type="gene ID" value="JCM18909_1249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="237" mass="25567" checksum="95BE37993A255B2A" modified="2014-03-19" version="1">MAEKSHGTMPLISIAPALGDLAAQGVKVYKDGKFTFNTDQAVEIIQKYVELYAKKAMPPEVLQNNYLGNSKLFLQGKVAWTTGSASFPVDLKKSAPKLLPHVAMTTRIGVPPLFVQGICVSADSKNPNLALAFAQYVTNNANQVDFVKLAQGFLPGTKEANENTDSFTSVISDPQMKKAAEALADEMKSAKIGEPMAYTDAMKAYVGQQISSAMRGDISAKDALDRAVKYCNDHVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ1</accession>
    <name>W4THZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68560">
        <property type="protein sequence ID" value="GAE68560"/>
        <property type="gene ID" value="JCM18909_1707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="4137" checksum="715ECC9688CC3D49" modified="2014-03-19" version="1">MLPKRSGSRAVTDQRGAICGAATLVVKVGSSSDSSWWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI24</accession>
    <name>W4TI24_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68605">
        <property type="protein sequence ID" value="GAE68605"/>
        <property type="gene ID" value="JCM18909_1752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="150"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="345" mass="38588" checksum="4D774AAFAD538FDD" modified="2014-03-19" version="1">MEAQRLRMRTTYDIEMMQQVGACAGIENYSRHIDGRAPGSAPNCLLDYFPEDFVLVIDESHVTVPQIGGMYEGDMSRKRTLVEHGFRLPSAMDNRPLKFDEFTQRIGQTVYLSATPGSYETERAHGVVEQIIRPTGLVDPEIIVKPTHGQIDDLMGEIRTRADRGDRVLVTTLTKKMAEDLTDYLMEHGIRTRYLHSEIDTLKRIELLKELRMGEFDVLVGINLLREGLDLPEVSLVTILDADKEGFFCVLNGPLSRPSAAPLVTSTVRSSCTPTRSLIPCRSPSTRQIVVAISRWRTTRNMGSIRSRCARRSAISLRCWLAKVPTLTSSSKSSTMGKATAATTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI58</accession>
    <name>W4TI58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Low-affinity inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67844">
        <property type="protein sequence ID" value="GAE67844"/>
        <property type="gene ID" value="JCM18909_934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="14374" checksum="FD1E2DD40E2D4BED" modified="2014-03-19" version="1">MRTMGKGLCDIESPQGFAAETASTAAILASSHLGFALSTTHVCSGSILGSGIGRHTEVRWATAGKMVIAWLVTLPAAALVGAVTSAVAGAGTWGVIVDLALLAIMAALIVRQANQHKVDHRNVNDSTQVGVRKGSAVAGGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIA3</accession>
    <name>W4TIA3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinone-specific isochorismate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68262">
        <property type="protein sequence ID" value="GAE68262"/>
        <property type="gene ID" value="JCM18909_1386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7339" checksum="B7FAE9CE9DBB6E3A" modified="2014-03-19" version="1">MHRNYGMVGLGEVTRFETDSPAAADVWWEALCDDLEHETEMPGAEATDQSPSDPSPLTQTGHRHGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE4</accession>
    <name>W4TIE4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68541">
        <property type="protein sequence ID" value="GAE68541"/>
        <property type="gene ID" value="JCM18909_1687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7870" checksum="06DDB4228FAAF547" modified="2014-03-19" version="1">MPFLQIRNVKMKGITLEGVAAIDVVGEAIGKLTQRGVIAETDYPLVRALYDIVDHDAPLDLPWEKFFGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK5</accession>
    <name>W4TIK5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine phosphatase PPP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68367">
        <property type="protein sequence ID" value="GAE68367"/>
        <property type="gene ID" value="JCM18909_1496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19289" checksum="933674628C56A612" modified="2014-03-19" version="1">MKRMTHDHSWVQSLIDDGRITPEEATVHPHRSLLLKVLNGQPQHIPDTQIVDLRLGDRILFCSDGLCGLVNDDTIGEHLNTTNLDDVVDLLTTDAHAGGGTDNITIVVAEVVEADPNLDASEPHIIGAATTRKVPEHESPPHCPSINRHPQQTMTASQPYCSTPRPKSRCATPPLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR3</accession>
    <name>W4TIR3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68318">
        <property type="protein sequence ID" value="GAE68318"/>
        <property type="gene ID" value="JCM18909_1447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6720" checksum="BD2D01D3F048CA79" modified="2014-03-19" version="1">MTYHPSCHGKRLLNLGDRPYELLRHVKGMTLVDLPMAEQCCGFGGTFCIKKPRYERGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIT1</accession>
    <name>W4TIT1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ccs1/ResB-related putative cytochrome C-type biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68054">
        <property type="protein sequence ID" value="GAE68054"/>
        <property type="gene ID" value="JCM18909_1163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15073" checksum="76A0372866AC4E89" modified="2014-03-19" version="1">MPSNIYTLDTTRLTQVTNGKDKARFVLSPGQRYKLPDGKGSIQFNGWQRWAKIQVSQNPGLPLTFLSVVLSVAGLCVSLFSRSRRVWVRTIPGDDGLRVEIGGLDRSDSRSGAVDDVNSLLAALHGDSMSGDVEEEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIT3</accession>
    <name>W4TIT3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="5" type="ORF">JCM18909_2040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68870">
        <property type="protein sequence ID" value="GAE68870"/>
        <property type="gene ID" value="JCM18909_2040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="18"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="23350" checksum="4BEE6DDC113463D2" modified="2014-03-19" version="1">MTDQTVTGRDLGGVFVVFEGGDGAGKTTQARLLDQWLTIEGIPHLMTREPGDSWLGQRIRQLVLSSDSGPISSRAEALLYNADKAQHVDEVVIPALREGKVVVCDRYVDSTIAYQGAGRVLDPGEVGQLACWATTGLVPDVTVLLDVDPCEGAGKIAAKDRLEAAGDEFHLRVRQHFLDLAAAHPQRYLVLNARKSRKEINEAIRQRVTGLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU3</accession>
    <name>W4TIU3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68069">
        <property type="protein sequence ID" value="GAE68069"/>
        <property type="gene ID" value="JCM18909_1181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004716">
        <property type="entry name" value="PTS_IIA_glucitol/sorbitol-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036665">
        <property type="entry name" value="PTS_IIA_glucitol/sorbitol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40398">
        <property type="entry name" value="PTHR40398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03829">
        <property type="entry name" value="PTSIIA_gutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141530">
        <property type="entry name" value="SSF141530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51097">
        <property type="entry name" value="PTS_EIIA_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="12902" checksum="B87E4987BBC8984E" modified="2014-03-19" version="1">MSVIYRNQICAVGSQAESFLSEKMLVTFGGKAPDELRDFCYTLPEATSSGTIGVGDVLAIGEHRFPITAIGALAQRNLDSLGHVTLVFDGADEPRLEGALHVRCGGELPRPQAGSTILIESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV6</accession>
    <name>W4TIV6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68084">
        <property type="protein sequence ID" value="GAE68084"/>
        <property type="gene ID" value="JCM18909_1197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6024" checksum="7F8F8104DEAA3590" modified="2014-03-19" version="1">MAVFGKQLKSAATSPTISTWEQVASKMDAQVEKVCRSGLTPAQALKTAQNEATSIGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ07</accession>
    <name>W4TJ07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68517">
        <property type="protein sequence ID" value="GAE68517"/>
        <property type="gene ID" value="JCM18909_1661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8501" checksum="AFAEFCD72DC4BB80" modified="2014-03-19" version="1">MLSAPPSRRIDGTFTDESLSDDITRRLKPLAEAAHTRNATVLIDPSLIDEVRAMASGYLVAGKAHTLSPELAKSRPRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA5</accession>
    <name>W4TJA5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68488">
        <property type="protein sequence ID" value="GAE68488"/>
        <property type="gene ID" value="JCM18909_1630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12508" checksum="368422F66DC77439" modified="2014-03-19" version="1">MPRCPSPSHAIIDLPAIAANLAIVRKRAGDRKVLFAVKADAYGHGAVEVSRYVEKNTGMPTGSPSPRSLKAKSWLKPASPCPYSNSPPPIFGTWMQPLRPGFVSPWWISTPWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJF1</accession>
    <name>W4TJF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription-repair coupling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69080">
        <property type="protein sequence ID" value="GAE69080"/>
        <property type="gene ID" value="JCM18909_2264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17554" checksum="70FB88CBE2209B12" modified="2014-03-19" version="1">MTSFAVADQRSTDETHQELICAPCRELILTDEVRSRAKALLTDHPELADMLERIGNGQAVEGMEALMPALVDEMELLVDVLPEHAMVVLSDPEMVRSRAADLVRTSEEFLGAGWAAAAGGGQAPIDLAASGYRSLAQVRSHCLERGMAWWSMSSFFSGFSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH1</accession>
    <name>W4TJH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69105">
        <property type="protein sequence ID" value="GAE69105"/>
        <property type="gene ID" value="JCM18909_2292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14585" checksum="C5703A1BDA947D89" modified="2014-03-19" version="1">MIGDDLDFASRHPVQGGDHDHPVVLERRRLQFVLYNQGRITSRVLLAEGERIVGAPLDRVLGGALVGFLLDRPVPDTPEQFFLTSSLLSPRTALSKVRLASYETSFPGLRCIAVLVFLVSSGTSNVKGASPLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP1</accession>
    <name>W4TJP1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase PrkC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68359">
        <property type="protein sequence ID" value="GAE68359"/>
        <property type="gene ID" value="JCM18909_1488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="291"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="366"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="478" mass="49969" checksum="19A9E4D62E28A509" modified="2014-03-19" version="1">MDFGIARAVADTSATMTQTAAVIGTAQYLSPEQARGETVDNRADIYATGCLLYELLVGRPPFIGDSPVSVAYQHVREVPAPPSSLDAEITHQMDAITLKALAKDPADRYQTAKQMRDDIDRLLSGREPFAMQNYADSEANTEEQTHLIPAATTDPVPATAAQQDEASPASAESPQEPEKPHRKRWPVVVVTIVVVVLLALLGFGLHKILNSSSQPSPAPTPSRTVKMVKVPAVTGLSQQGATSTLENAGLKVQVDHVQKDQATANQVVSQSPAANEKVPAGSDVKITVNDGPKQLTIPRNIVGLPKNEALNALKDAGFSDSQIKVTNDDPKTEPNSAKAGAVDAVSPGAGTRLTPDQQVTLTIATGKSVVPNLKGMSVEEANSAAGSSGFSISVERQVTSSAAPGTVFGQDPDYGAIANRSTAIKVLVAVAPPAPEPTREPPTNSAPSEEPSSSSIAPVPPAPTTAVPRLVRRRAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT6</accession>
    <name>W4TJT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylmuramoylalanine-D-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68693">
        <property type="protein sequence ID" value="GAE68693"/>
        <property type="gene ID" value="JCM18909_1844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="226" mass="24033" checksum="391779CA3079A725" modified="2014-03-19" version="1">MTFSGKVDLSAADRLFDWSGVHVVIAGLGTSGYAAADALLELDATVLVLDDCDDDSHRDKGGLLEVLGAEVRLGPGSASDLPEETDLVVVSPGWRPTQPLVAHALTRGIPVWGEPELAWRLMHPDRVIPWLAITGTNGKTTTTQMTESILHAAGLKACAVGNIGRPILEAMADEINYDVFCSGAVQLPVALVKLTVSPFRGSAQPSPRPPGVVRPRIGSARFVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU0</accession>
    <name>W4TJU0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68797">
        <property type="protein sequence ID" value="GAE68797"/>
        <property type="gene ID" value="JCM18909_1960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="278" mass="29964" checksum="E0939F0216F0DE92" modified="2014-03-19" version="1">MSLPLSTVTSLTCLESLPPWCASPPPQLLTIRLRQPFSGRLFGLGVRNMVLTLWQGAAESVERLSQADIVVSGGGSAANLMALWKMHGVDHVIRRMIAADSDVVLAGVSAGAACWFSGCLTDAFGDLRAWRGGMGLLDGSFCPHFDGESERALSTPKRSPTGCFLADTRSTMGRRCILSTECSLGRSLSMKGPRYQGSLPLTSRHRREFCARSSTSPCCDRFLAVVVQVLAVSVVRQVREEVDDPTCPGDIVKHHLVGRGSEDECSAAHHPVKQRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU3</accession>
    <name>W4TJU3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68802">
        <property type="protein sequence ID" value="GAE68802"/>
        <property type="gene ID" value="JCM18909_1965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="27823" checksum="CCC4C7B5E99BD65C" modified="2014-03-19" version="1">MTWGNANLVAPVLDLFRAPIDNDRASSLARNTIGDAALAAGLDRLVHTTTSVRDEGDELVVVTRSAAAAARNSMTTTWSWRAIQTNDGSEGVHLDLHVDPHGYWPTMLGRIGVTIGLPAEWTTVSWFGLGPTENYPDSQHAAIWGRWNGEVDDLQTPYVMPQENGLRQGVHELTISGSNGGLRITADGSWPAFAARPWTSQALLAAAHTWDLKPDGHTWLTLDAVSAPLGSTSCGPMPIMSHRLYAQPVDLSLTLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU4</accession>
    <name>W4TJU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69225">
        <property type="protein sequence ID" value="GAE69225"/>
        <property type="gene ID" value="JCM18909_2419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="311" mass="33294" checksum="B98364DA6930DAF1" modified="2014-03-19" version="1">MTTMPSGTLTALDRGRHFLALLKAGERPRAHWRVSPVCGPGDDDHLGDWCNGLLQAVCATLTSGRSAVVCCPTVDDVITLHARFQAVLGAGTVAVLHADQPASTRWRHYLAVIRGTAKVVVGTRSAVMAPMADLGLIAVWDEGSDLHDEPRAPYPNTRDVAALRAQIDHCALLLASYSCSVRSASWLGSGWLVGIGADRPTMRAVCAPVRIPGDSDIAMERDPLARSVRLPDLAMTTIRDGFFCMAPFWFPFRELAISSPHRAHAVERQCDALRAVDRLPGGVLNLGSISIAPGVAVTYHRGAVPNVASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU7</accession>
    <name>W4TJU7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68807">
        <property type="protein sequence ID" value="GAE68807"/>
        <property type="gene ID" value="JCM18909_1970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9675" checksum="BBF612E5F0ADED5D" modified="2014-03-19" version="1">MPTSTYAWRWVARGLPPLSGLTRWASLAIGSIQLSRRTPRGLRLWGLLGEGATTGLGAPVCPWTTRPIGRAARRVHWIDTGGVVFVNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ7</accession>
    <name>W4TJZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68857">
        <property type="protein sequence ID" value="GAE68857"/>
        <property type="gene ID" value="JCM18909_2024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13169" checksum="6AF399F8E581EAE2" modified="2014-03-19" version="1">MAESKGSAHGSLYTRLGELQAMTPTDAIIAQYCEDSFPHVALENLDEISAATGTSTASVTRFVRKLGYASFRDFSRSFVRRSPLTLTFLVIAQPMTPRLMSREPCGVPRWKLSDAALILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK22</accession>
    <name>W4TK22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68469">
        <property type="protein sequence ID" value="GAE68469"/>
        <property type="gene ID" value="JCM18909_1609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18999" checksum="7E5EBBC65B5616BB" modified="2014-03-19" version="1">MLPPDDLDRELAQSLAVDGRTSATSLARTLDVPASTLHRRLQKLLTNRQIELRCDVAPELGGWSLECAWTATIPLNHKTRVLELLRQQSGLRSCMWITGSSNLRVNFRVERQNGIGMIESAVAEAIPGLAPAETIVYMRSHKSMGWVLDRDGRATGEFVCPPLIGASERADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK89</accession>
    <name>W4TK89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68922">
        <property type="protein sequence ID" value="GAE68922"/>
        <property type="gene ID" value="JCM18909_2097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="266" mass="27929" checksum="12397C8FA8FFAED3" modified="2014-03-19" version="1">MLIATDLDGTFLTPDATVSPRNRAAVKVAEAAGIHVIPVTGRAIGGLRVIGPVFHRHALVSNGAVGTDMSTGETLFTETMSARTVKSYVDQLTAECPGVVFCAEVGDSSVFLVEEGYDEIVPAFESENDPAEHVLVSRKELCSSEAVKLMIVHPTVPASDIYQLSRRLRVPGVHATWAGFTVAEAGPAGGTKASGLERICQLLGEDRAHVVALGDGANDVEMLQWAGVSYAMGGAKPEAIAAADRRAPSCEEDGFAVVVEELLASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA7</accession>
    <name>W4TKA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68579">
        <property type="protein sequence ID" value="GAE68579"/>
        <property type="gene ID" value="JCM18909_1726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16156" checksum="16BFA1921018A134" modified="2014-03-19" version="1">MSSHNQLVAELTARWPEHRIGPGLDRERAVFDLLGNPQQACPVIQIAGTNGKGSTAIMVDSLLRSAGLRVGRYCSPHLVDVTERICIDGRPVSHDLFDETWRQLEPMVGLVDAQHIDGIEMTFFEVMTAMAFAAFADAPVDVAVVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB0</accession>
    <name>W4TKB0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_1731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68584">
        <property type="protein sequence ID" value="GAE68584"/>
        <property type="gene ID" value="JCM18909_1731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="335" mass="35936" checksum="56DB432B6454F711" modified="2014-03-19" version="1">MTVKVGINGFGRIGRNFFRALAEQGADLEVVAVNDLTDTKTLAHLLKYDSIMGRFSGEVSYGDDSITVDGKTIKVLAERNPADLPWKELGAEIVVESTGLFTDGEKAKAHFEAGAKKVIISAPGKNVDGTFVMGVNDGDYDNAKHNIISNASCTTNCLAPLAKVLNDAFGIERGIMTTVHAYTGDQRLQDAPHKDLRRARAAALNMIPTKTGAAQAVALVLPELKGKFDGLAVRVPTPTGSLTDLTFQTSKETTVEEVQAAVKKAAEGPLKGILAYTEDLIVSKDIEGDPHSSIFDATETKVIGNLVKVLSWYDNEWGYSNRLVDLTKLVASKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE9</accession>
    <name>W4TKE9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68634">
        <property type="protein sequence ID" value="GAE68634"/>
        <property type="gene ID" value="JCM18909_1783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6132" checksum="43291FF16F55A688" modified="2014-03-19" version="1">MNDWLSTTAGRIGVDVTGSWGSGSGDVEAVALGGVDGNAVWFDAAELSPEDEDVFCRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH3</accession>
    <name>W4TKH3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exoenzymes regulatory protein AepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69440">
        <property type="protein sequence ID" value="GAE69440"/>
        <property type="gene ID" value="JCM18909_2655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8072" checksum="3F63ACFA1FA785AC" modified="2014-03-19" version="1">MLTDADVRRFAALGVRASIQPLHLVDDRDATDVMWADRADRCFRFADMVRAGTELALDQTPQSPPSIRGARSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH4</accession>
    <name>W4TKH4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69027">
        <property type="protein sequence ID" value="GAE69027"/>
        <property type="gene ID" value="JCM18909_2208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8540" checksum="12140806B8986560" modified="2014-03-19" version="1">MRQWAVFHQPSAAPTKLTVFVAVSLTKSYEQIGEQFERKYPRVDVQFSFEGSQNLVAQMAQGPRLMSWPPLIRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ3</accession>
    <name>W4TKJ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine oxidase ThiO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69047">
        <property type="protein sequence ID" value="GAE69047"/>
        <property type="gene ID" value="JCM18909_2229"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012727">
        <property type="entry name" value="Gly_oxidase_ThiO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02352">
        <property type="entry name" value="thiamin_ThiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="3">
        <location>
            <begin position="44"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="414" mass="44076" checksum="1FCED7E879B33999" modified="2014-03-19" version="1">MGTAATRPEFAGSTVVGHVDTKSHNHAAETSTIPPSERGRPSSVVIAGAGIIGLTTAWRLRRRGIEVTVLDDAPVSGASFAAARMLAPVSEVVWDQPTLYPLMVESGRIYRDFAAAIAHDVGHDIGYLESSTFVCAGDSADRQTLNELLELQHRMGMTVNRISVSQARAEPALGPGCVGVVDIPGDHQVDPRRLCGAILEFLGDRVIPNRASEVLFNEDHRAIGLRGANGKSYRADHVVLAAGVDTGAITGIPQALTDLLRPVRGEVLRLRVPEALRPLVTRTIRGVVQGNAVYIVPRADGTIVLGATTREDDMVGVRAEGVHQLLRDAHRLVPGILDCEIYEMTAKARPGSPDDVPMIGRVGDGLTVSMGYFRHGILLAAIGSKIGADIVCGTEKDNNPALLAAVNPFRFGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK9</accession>
    <name>W4TKK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69480">
        <property type="protein sequence ID" value="GAE69480"/>
        <property type="gene ID" value="JCM18909_2699"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849286" evidence="1">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6717" checksum="F847653FD68B870D" modified="2014-03-19" version="1">MPSATLSRSHSVLLPLSLAAHSPKRARLVAMSTNPEIPQWFALTLRVWTTSVEPESVTCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR8</accession>
    <name>W4TKR8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69013">
        <property type="protein sequence ID" value="GAE69013"/>
        <property type="gene ID" value="JCM18909_2193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="15931" checksum="5D9D9EAC3ADF0589" modified="2014-03-19" version="1">MGLLFGLMILMVPTVLRSTEEMLKLVPDSLREASFALGVSQWKTIMKVVLPTSITGILTGIVLGLARVMGETAPLIVLLQFNTKLTFNPSTPNFATLPTVITNAYTQGGVDTPVVWGAAITLIIVVMGLNLIARRISRRYMRRMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL79</accession>
    <name>W4TL79_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69287">
        <property type="protein sequence ID" value="GAE69287"/>
        <property type="gene ID" value="JCM18909_2487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032576">
        <property type="entry name" value="DUF4921"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16268">
        <property type="entry name" value="DUF4921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF4921" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="6120" checksum="92545A38AED2592C" modified="2014-03-19" version="1">MPVPWRIILKLRTSTLAGFEGGTKIYVNTISPTTLPPCCCRNCVRREQLGESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH3</accession>
    <name>W4TLH3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division trigger factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69367">
        <property type="protein sequence ID" value="GAE69367"/>
        <property type="gene ID" value="JCM18909_2576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16265" checksum="CD3A9F98D36A644F" modified="2014-03-19" version="1">MLFRKAQQNGTSPEEEAQHMMEHNHLPDWMQEIRRGKALASMVGAATVTDSKGNALELDRIQPDGTIADKQAEEDAPAEDSAEKVDGEATEEPKAEEKAPAKKATAKKTSAKKSAGAKATTKKVADAKSDDKPAAKEPAPKKKTAAKDDKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK0</accession>
    <name>W4TLK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69621">
        <property type="protein sequence ID" value="GAE69621"/>
        <property type="gene ID" value="JCM18909_2860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7197" checksum="E92565C317389089" modified="2014-03-19" version="1">MDWGWLDVDEVVETLLNRPGTQHVVITGRRAPDALVEVADIVTEMTKIKHPFDVGQRGQAGIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP3</accession>
    <name>W4TLP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69348">
        <property type="protein sequence ID" value="GAE69348"/>
        <property type="gene ID" value="JCM18909_2554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="329" mass="35642" checksum="071A01E9CFC1BFFE" modified="2014-03-19" version="1">MMWICFLAGLTLLAIALGIAQHHLVPTWPVCSPLTRTRVETWCYRVMGVNPRAGQTWKSYARAVLAFSFCGVVLLYALQRLQPWLPWSLGKGSVNPAVSFNTAISFVTNTNWQAYSPEATLGHFVQLAGLCVQNFVSAATGIVIAVALIRGFVGRGEHTIGNFWVDLTRCTLRILMPIAAVAAFLLIAGGAIQNFTGFLHVTGVAGGNQVVPGGPVASQEAIKELGTNGGGFFNGNSSHPFENPQPWTNMLEIFLILLIPFSLPRTFEDGGRCAAGQGDTRCDGRPVHRQPICHGRCRVFWPRYCRTSRGSRDGGQGAAFRISSVGPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR3</accession>
    <name>W4TLR3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69124">
        <property type="protein sequence ID" value="GAE69124"/>
        <property type="gene ID" value="JCM18909_2312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9596" checksum="2F9CDDDDD48F3185" modified="2014-03-19" version="1">MVTTASCLGTGPLGAWEMLEGATLNGSVWRPVNAQVDAARRGEHDTVVVPKALPAPDWLPDYAGRRGSTEAHLHQYYDLPKNVTVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM53</accession>
    <name>W4TM53_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribose operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70060">
        <property type="protein sequence ID" value="GAE70060"/>
        <property type="gene ID" value="JCM18909_3345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850830" evidence="4">
        <location>
            <begin position="31"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="27647" checksum="A30342F403E41900" modified="2014-03-19" version="1">MTHKPTIKDVARLAGVSLGTASRVLNGSSATSEASRSAVHNAAHELGYLSNAHARSLRSSHSGVIGLVVPDIRNPYFAELASVVENACLAHGWATLLCNADESPDQFNRYVNTLRRQRVDGAIVTPTGSDGQAVKDLVDDGVQVVCVDREITGSPLPAVTSDPWNGMRQAVDHLVDHGHRRIGFITGPQQTSTGLERYQAYRQLLAEHGLEVDEDLVVEGDFQEESGRVGARRLLDGGATAIFCVRLPHVDGGAADMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM64</accession>
    <name>W4TM64_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69493">
        <property type="protein sequence ID" value="GAE69493"/>
        <property type="gene ID" value="JCM18909_2713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6987" checksum="25563F32FB6CB976" modified="2014-03-19" version="1">MDHLGFPHVESLGQFVDLVQAHVAPFFVNSGRFLAFGYIDSTTWIAVFSSTVTMPNFMIASPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM71</accession>
    <name>W4TM71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69289">
        <property type="protein sequence ID" value="GAE69289"/>
        <property type="gene ID" value="JCM18909_2489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8284" checksum="7A02ECD20338685A" modified="2014-03-19" version="1">MLYHLSEEHEMLRQFVREFAESQLAPNAAEVDDKGVFLRSSSMMLSLRRVSRLLESQSSMVATVRMRLRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM98</accession>
    <name>W4TM98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69657">
        <property type="protein sequence ID" value="GAE69657"/>
        <property type="gene ID" value="JCM18909_2902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="237" mass="25289" checksum="CBCFB2D2D46910CF" modified="2014-03-19" version="1">MDEVKISGTDDVTIILDRPRAINSLSGEMLGAIGEAVKGSPRSIDLSGAGERGYCSGADIRELRSLALKDPEAAGDWLDGEYDVDAAIAEVHSGTAHLQGISMGGGLGLALRLKRVEARDDLVLAMPETGIGLWPDVGACFELSRAPRLVGRHIAMTGASIDAASALWAGLVDEVVDADGEPVDVDPVACQLARDAVWIQECYDTDDPSRCVVDWLIVPSRPRVRRLSTSRRAVRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM99</accession>
    <name>W4TM99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70110">
        <property type="protein sequence ID" value="GAE70110"/>
        <property type="gene ID" value="JCM18909_3401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9410" checksum="1CEA78BB04692F59" modified="2014-03-19" version="1">MFASEHFGVVPDAITVAKGLGGSGAQVAAIITNDGLLGLEPDHHSFTYGSNLIAAAAANATLKIIREPAFLQNVTIVGDYIMQRMRALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA8</accession>
    <name>W4TMA8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA large subunit methyltransferase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69856">
        <property type="protein sequence ID" value="GAE69856"/>
        <property type="gene ID" value="JCM18909_3115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18972" checksum="F2327DAD98FBE142" modified="2014-03-19" version="1">MSARALTLSTVGLVPRIKALTEEGIPVTLAVSLHAPDDELRDELIPVNRRWKVDELLDAAWHYAEKTKRRVSIEYALMKDINDQADRAAVLARQIRRRGDWTWAHVNLIPLNPTPGSRWTASRPEDQDAFVETLERWKIPVTVRDTRGSEIDGACGQLAAVGRSEGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH9</accession>
    <name>W4TMH9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69747">
        <property type="protein sequence ID" value="GAE69747"/>
        <property type="gene ID" value="JCM18909_2996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="193"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="403" mass="44821" checksum="218F0CFAC6471B29" modified="2014-03-19" version="1">MMTSVPGPLIVQSDHTLLLEVDHPQADECRHAIAPFAELERAPEHIHTYRLTPLGLWNAMAAGHDAEQVVDILMRYSRYPVASGLLIDVTETMSRYGRLRIEKHPTHGLVLVSTERAILTEVLRSKSVRGLVGNQIDDETAVVHPSQRGTLKQALLKLGWPAEDLAGYVDGEHHDIDLDEDGWSLRPYQKVAAQSFWDGGSGVVVLPCGAGKTVVGATAMSLARCTTLILVTNTVSARQWKEELVRRTSLAPDDIGEYSGSRKQVRPVTIATYQVITTKRHGVHPHLELFEARDWGLVIYDEVHLLPAPVFRMTADLQARRRLGLTATLVREDGHEDDVFTLIGPKRYDAPWKEIEAQGWIAPADCVEVRVSLSESDRMACAMAEPDVRYRMAATLPIKKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS3</accession>
    <name>W4TMS3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="8" type="ORF">JCM18909_2698</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69479">
        <property type="protein sequence ID" value="GAE69479"/>
        <property type="gene ID" value="JCM18909_2698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="103"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="339" mass="36395" checksum="9D999B210F9EFD65" modified="2014-03-19" version="1">MLDDRKLDVLKAIVTDYVSSKEPVGSKALVERHGLRVSPATVRNDMAVLEEEGYITHPHTSAGRIPTDKGYRLFVDRIATLKPLSAPERRAIQAFMTGAVDLDDIVRRTVRLLAQITHQVAIMQYPVAATGTIRHLELVSLSTDRILIVLIMSSGSVEQQIVELPGHDEQSLAALRTRLNEALVGLTVAEAADSLNRFLDDLGPAEGPRAASVIATVLEVLAVDPSTRVVVAGVPNLTAFGAQWETAVRPVLEALEEQVVLMRLLGEATAGEAGEVMVRIGAENTDVPFQSTSLVASTYGPEDALSSLGVVGPTRMDYPSTMAAVRAVARYVGRFLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT0</accession>
    <name>W4TMT0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LSU ribosomal protein L31p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70021">
        <property type="protein sequence ID" value="GAE70021"/>
        <property type="gene ID" value="JCM18909_3301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8149" checksum="564D6E2AB8E420D2" modified="2014-03-19" version="1">MKQGIHPDYHPVVFRDISADMAFLTRSTVTSSTEIEWQDGNTYPVIDVDITSASHPLLYRQGQDCRHRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT9</accession>
    <name>W4TMT9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69499">
        <property type="protein sequence ID" value="GAE69499"/>
        <property type="gene ID" value="JCM18909_2720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010179">
        <property type="entry name" value="CRISPR-assoc_prot_Cse3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08798">
        <property type="entry name" value="CRISPR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="4745" checksum="4E06CA4B7FD67C64" modified="2014-03-19" version="1">MTLAVTQVDGVIQIQDADAARLTLVQGIGPAKSYGCGLMTLAPTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY0</accession>
    <name>W4TMY0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70076">
        <property type="protein sequence ID" value="GAE70076"/>
        <property type="gene ID" value="JCM18909_3361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015577">
        <property type="term" value="F:galactitol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013853">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37324">
        <property type="entry name" value="PTHR37324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="11684" checksum="3FF51D9C6B1EE129" modified="2014-03-19" version="1">MSIIKGILDVGAVVILPIVMLILCLIFRMPFGKSLKAGLMIGIGFSGLSLVIGFLMTSVQSAVDYYRHMGGGFTTVDVGWAAVGAASFGVPFAAPAILLVVLINVVMILAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ1</accession>
    <name>W4TMZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0098 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70091">
        <property type="protein sequence ID" value="GAE70091"/>
        <property type="gene ID" value="JCM18909_3381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16386" checksum="90B28BA9F1E6D122" modified="2014-03-19" version="1">MKITSTSITEGQPIELAYAHADAGGKNVSPQLSWTPGPEDTKSYAITIYDPDAPTGSGFWHWILADIPADVTSLDEGGPLPAGVREWTNDYQEGGYSGACPPPGPAHRYIHTVHAMPTEHLDIPDDAANVQVRFAIHTTELDSASITGTFQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN16</accession>
    <name>W4TN16_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69808">
        <property type="protein sequence ID" value="GAE69808"/>
        <property type="gene ID" value="JCM18909_3063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13440" checksum="7F3321BAC3DB0B2C" modified="2014-03-19" version="1">MVGITDDPSALQTAPAYVGQLPGQTPNTWVIKAKDGTTPGQLVTNLEKTLPKVKDAPQFNKDDAGATISTADSFQKKTINSLTEDFDVTKYMLMVFGAIALLVGAIIITTTFLILLAQRRRQIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN43</accession>
    <name>W4TN43_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70146">
        <property type="protein sequence ID" value="GAE70146"/>
        <property type="gene ID" value="JCM18909_3442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="4">
        <location>
            <begin position="94"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="380" mass="43058" checksum="3AC4BB2C271AB965" modified="2014-03-19" version="1">MTTTVTASAENTASHPEFPGVYADEPVDSPDPDEKSFIVGTDSLQVIIRDCPLRMTWQRRADDWVTVSEDRPTGAYEIGTHTGRVAHHRVRNIDDRYYGLGEKSGDLERTGRIFDMRCLDALGYDAGSTDPLYKHVPFLMTRTANGAFGIFYDNLSASRFNLGAEVDNYHRPFTSWQADHGDIDYWVMTADHLCDLTPQILRLTGDPAFLPRWALGYSGSTMHYTDAPDASHQLLKFIDLLREHAIPCDSFQLSSGYTTIGSRRYVFTWDRDKFPQPTETTRHFRDAGLHLAANIKPATDDAPLLPRCGRGGDFFCHQLPDWGTGDVDVLGRSRQQRRLHQPARSAVVEGQHPPPAHRHGRRIHLERQQRVRIVVRGRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN84</accession>
    <name>W4TN84_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69987">
        <property type="protein sequence ID" value="GAE69987"/>
        <property type="gene ID" value="JCM18909_3263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="5">
        <location>
            <begin position="13"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="326" mass="36376" checksum="19A5432F1ACCF7DA" modified="2014-03-19" version="1">MTRRAKHIREGGIDWATGEMIALGSLLRDGVHVRLAGQDSRRGTFSQRFAALVDHETGEFYVPVNHLGGEQAHLDVFDSPLNEYAAMGFEYGYSVARPDSLVLWEAQFGDFTNGAQTIIDEFIASAGSKWGQKSGVVLLLPHGYEGQGPDHSSARLERFLNLCSEDALAVCQPSTPASYSHLLRQHAYVNMHRPVVIATPKSMLRNKMATSDPEEFTTGRWRPVLPDPSITDPTAVTRIILCSGKVRWELVKQRKAAGLDGQLAIIPMERLYPLPVDELAEVLAPYTNVTDVRWVQEEPENQGAWYYMLTHLPRPCRRSCQDSLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA4</accession>
    <name>W4TNA4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="7" type="ORF">JCM18909_3743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70425">
        <property type="protein sequence ID" value="GAE70425"/>
        <property type="gene ID" value="JCM18909_3743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="108"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="123"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="163"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="209"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="333" mass="35397" checksum="EFF2E1F0C5659F78" modified="2014-03-19" version="1">MSPRRLASSGIDMRDWSSYDRPKRRTKPRTKQRPDYSSLPIGTVITIDRGRYRCRLDDGVEVTAAKARQLGRKSVIVGDKVRLDGDVSGAEGSLARIVHTEERATVLRRTADDADPHERPIVANADQVVVVTALADPPPRPGMIDRILVAAHAAGVSPILCLTKTDLASGDDFVAMYSQLGIPVTTSQPGADLAELHQLLAGKVSVLVGHSGVGKSTLINALVPGVNRVTGHVNDVTGRGRHTSTSAEAIPLSEGGWIIDTPGVRSFGLSHVPAGDILAGFEELDAVSVDCPRGCQHTNSSPECALDDAVSDGRVQQSRVDSLRRLLGATTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND8</accession>
    <name>W4TND8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lacto-N-biose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70470">
        <property type="protein sequence ID" value="GAE70470"/>
        <property type="gene ID" value="JCM18909_3797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035356">
        <property type="entry name" value="LBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035363">
        <property type="entry name" value="LBP_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17386">
        <property type="entry name" value="LBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17385">
        <property type="entry name" value="LBP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LBP_M" evidence="2">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_C" evidence="3">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="184" mass="19902" checksum="2ECCF35DEB514F40" modified="2014-03-19" version="1">MHTSDHHFVTLDLSSHLDVGEGTPDVFCASATTTVLAAHHEQVDLAVNQFGCGRAVYLAGLPYSSQNARLLHRALAWAGHREDAFTTWTSSDVRAEVAVYPHSDRLLVINNSLDQVTTTVSTPTTVREVHMEAAGTCGSTSNFIPRTSQAEPSKTQFSLRILTAGQQQGKSVRQPPHARPEAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM1</accession>
    <name>W4TNM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70560">
        <property type="protein sequence ID" value="GAE70560"/>
        <property type="gene ID" value="JCM18909_3905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="342" mass="35025" checksum="ABBA935A3D1746D1" modified="2014-03-19" version="1">MARPSIVKRVHPLTALLWVVSVVAVVWAADHIVVSLAGLVTLCAVAIVAGGPRRSVWIPAGEVCGVLVVLWLLLLVSALGHSITTGAVVATLPSIGFGSQQIGGPVHTGAAIGAANHAVQACVAVTAGATLVQLRPARNWLDLGMCWLGRGARIIAPGVCVAEGIALAVADRARLRRGGLRTSRLDALLDGIDRGRQIESGWEEARLGQVAPAVGPCAGGDRDTRCNAGMHSPNHDGVDTVHIAALDPWRDRALIVAAGLWAATGLVVLMVRGLPGVGRLRLVDVSLILAAIATAVAWLLRDRTGDGPALTSTAGTPVVMCAVMVAGAAAVVFSFNAGGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNQ4</accession>
    <name>W4TNQ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MarR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70361">
        <property type="protein sequence ID" value="GAE70361"/>
        <property type="gene ID" value="JCM18909_3677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8619" checksum="254A470292F92353" modified="2014-03-19" version="1">MNGLTPDHTDVEIALQASWALVDVAARSLAELAEDVSAPQYRLLVLIDAGVTRGVDLARDLDVHSSTIARMVERLVAKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT1</accession>
    <name>W4TNT1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70197">
        <property type="protein sequence ID" value="GAE70197"/>
        <property type="gene ID" value="JCM18909_3495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="PTHR11465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="SSF56634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="320" mass="35358" checksum="D251B6FBB5537743" modified="2014-03-19" version="1">MPIDPSKPSTNTNGSPAPSDEYSLTVGADGPVVLHDAHLVDTLAHFNRENIPERKPHAKGSGAFGHLEVTADVSEYTKASFLQKGRETPMLARFSTVAGELGSPDTWRDVRGFSLKFYTDEGNFDMVGNNTPVFFMRDPMKFPHFIRSQKRLPNSGLRSPNMMYDYWSLSPESAHQVAYLMGPRGIPLSYRTMNGYSSHTYSWVNAEGKITWVKYHFISDQGVHNMTADRAKAIVVITQISTARTSSTTLPTATIRPGPSRCSSCPMTRPRATGSTRSTSPRCGRIRITRCTPSASSLWSATRRTSSPDRASGLLPVEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU2</accession>
    <name>W4TNU2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70068">
        <property type="protein sequence ID" value="GAE70068"/>
        <property type="gene ID" value="JCM18909_3353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="113" mass="11835" checksum="96AE9F6D225F9014" modified="2014-03-19" version="1">MVRRDVLTGTAVVMVADSGENSIIVVAAANGTVGAQTVRAQAERIQDADVVVCQGEIPPDGIAEAARGAKRFVFNLAPVVDVDPEVIRMADPLVVNEHERLGGSCFGIDDFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV5</accession>
    <name>W4TNV5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_3520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70222">
        <property type="protein sequence ID" value="GAE70222"/>
        <property type="gene ID" value="JCM18909_3520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="11">
        <location>
            <begin position="286"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE70222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="380" mass="40885" checksum="BDE5524B2872DABE" modified="2014-03-19" version="1">MGDSLNLVAPTWRPDLVDAYDYVEEIGRKIGFDRIKAVLPPSLGASGLTKAQRGRRRVLRSVVEAGFVELITLPFIGDKDLDVLGISGDDTRHATVKLANPLDDTRPYLRTTLLPGLFHAVTTNMSRSQDDLAVFESGTVFRAVTPAAAPRPGVDERPSDEVLAEIDAALPAQPRMLAAVICGSWLPDRWDGESVKADWRHAVLVAQKAADALGVRLVRKADRQAPWHPGRCAALIVDGKVIGHAGELHPTVVSKAGLPQRTCAVEFNLDALVAAAPRGGEVMAISSFPVVKEDVALVIDKSVAAEDVRQALIEGAGQLLESVELFDVYEGEQVGDNRKSLAFNLRLRGADRTLTDSEALEARDAAVVRAEETCGAKLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW2</accession>
    <name>W4TNW2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="12">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_3383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70093">
        <property type="protein sequence ID" value="GAE70093"/>
        <property type="gene ID" value="JCM18909_3383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE70093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18516" checksum="4D03AFD9956EB232" modified="2014-03-19" version="1">MRIAGIEPESIVDGPGIRFTVFTQGCPLQCPGCHNPATWDPCGGQEVDVEEVIAAMNSSVLASGLTLSGGEASRQPRACARLARAAHGMGWDVWSWSGYTVEALMRQARRDAELADMLGQIDVMVDGPFQLVHRTLTLPWRGSSNQRVIDMPATLRGGQAVEWVDRAGNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW7</accession>
    <name>W4TNW7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II restriction enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000063">
        <property type="protein sequence ID" value="GAE70670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70670">
        <property type="protein sequence ID" value="GAE70670"/>
        <property type="gene ID" value="JCM18909_4045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="222" mass="24903" checksum="CC7ECB6F4DAD65A4" modified="2014-03-19" version="1">MEAASLAPDADGHVWWSEALDESIKHTVGVSQDLREGVRESIEIIANEVVSRRRDRGLEPLGQDQAQPLAMQSLRFLYRILFLLYAEASPELGVLPVGAPQYDAGYSLDRLRELVQVPLVTQRSMAGTHLYESLGTLFRLVDRGNLEDVDDTTTGLSFHSLRADLFRPQATALIDEVGLGNQALQQMLERLLLSKEQHGKKGPGARVYQLRRARHQPARRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP06</accession>
    <name>W4TP06_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucuronide transporter UidB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70148">
        <property type="protein sequence ID" value="GAE70148"/>
        <property type="gene ID" value="JCM18909_3444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="474" mass="51470" checksum="7C84C8CE7A9F6742" modified="2014-03-19" version="1">MSTITTKGQKAKAVDARDFDIRDMIGYALGDVGNNFTFNLVNSFLMIFYTNVFGLAAALVGALFMAARLVDAFVDIVVGRLIDNSTMTKRGRFTPWVMRMKFPLAASAILLFLPAAGRLPMTARVIYAFVTYLAWGIFYSFVNIPYGSMASAISGKPRDKTSLSTARSIGSASGAAIVSYVVPLIMYGSNSHQINPNRFFMGAAIFAVLGLFCYIGLTILTVERIRIDKTERVPLGKMFSEMAHNRALVMLVIIDIVVVINQNLSGVTLTYLFNDYFQNKTAMSIALVFNFTTVILVAPFAQTLVRNFGRKESATVALFFGAAMYGLMLIIHTHSPWIFLVGLFFGSLGAGVFNLMVWAFITDVIDAQEVMSGEREDGVIYGVNSFARKLAQAIAGGIGGAMLTMIGYQSSSQGGAVQSESVVNHLYTLATAIPTICCLGAALLMLGYPLTRDKVVANADELARRHAVQAEQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP29</accession>
    <name>W4TP29_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="5">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70466">
        <property type="protein sequence ID" value="GAE70466"/>
        <property type="gene ID" value="JCM18909_3793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="499" mass="56665" checksum="4E5357885794CC26" modified="2014-03-19" version="1">MTQDLASAIAFQVRSTSGRSVTASTPMEVWQGLSACVVGRIADDWQATDAAYKAGRQEHYFSAEFLMGRALLNNLSNLGLVNETREALASFGIDLSEVLEQEPDAALGNGGLGRLAACFLDSCATLELPVTGYGILYRYGLFMQLFDNGFQTEHPDPWMEEGYPFVIRREEQQRIVRYADMWVRAIPHDMPITGYGTRNVGTLRLWKAEPMEQFDYQAFNSQRFTDAIVERERTSDISRVLYPNDTTFEGKVLRVRQQYFFCSASLQEIVDNYIEHHGEDLTGFAKYNSIQLNDTHPVLSIPELMRILLDEHGMGWDEAWEVVTHTFAYTNHTVLAEALEKWEMQIFDRLFPRISEIVREIDRRFREDMNKRGLDGQTIEYMAPVSGNQVRMAWIACYASYSINGVAALHTEIIKRETLKEWHAIWPQRSTTRPTASPRGAGSTSATRVWRVCCPRSPALTPGSKTFQCSLTTLISWTSRFTTASTRSNTLTRSTSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP41</accession>
    <name>W4TP41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt-precorrin-8x methylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70302">
        <property type="protein sequence ID" value="GAE70302"/>
        <property type="gene ID" value="JCM18909_3610"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13504" checksum="C14C20D75439FD79" modified="2014-03-19" version="1">MAHEYVNNGSDIYRESFRIIRSEANLDRFPTDVEGVVVRMIHAAADPAIADDIAFTPAVVTAARKALGGGAPILCDSSMTATGIIRSRLPRDNETICYIKDPRLAEIAQAKKYDEDLRRGGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP53</accession>
    <name>W4TP53_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70312">
        <property type="protein sequence ID" value="GAE70312"/>
        <property type="gene ID" value="JCM18909_3626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9329" checksum="BE226631D83A664A" modified="2014-03-19" version="1">MEINAGRATRGEASAVAEMTMVCKKVEKRTNVLTGVDWYRIVGDTSIPMTLAVSANLPRVPHVGSVVTGQVVPVVSTGTWEGDASGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP61</accession>
    <name>W4TP61_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70501">
        <property type="protein sequence ID" value="GAE70501"/>
        <property type="gene ID" value="JCM18909_3828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9120" checksum="AD76559C231CD0E3" modified="2014-03-19" version="1">MMVNPAAISRSMTGTQIPDFHSAPRRRTPRGKLKASQLKPGSLEVWHGSLVSDSTVNRWVVLLPVHVALRQTEGRHSRVTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP87</accession>
    <name>W4TP87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3656</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70342">
        <property type="protein sequence ID" value="GAE70342"/>
        <property type="gene ID" value="JCM18909_3656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23342" checksum="C0AAC91720294468" modified="2014-03-19" version="1">MTETHRSSQPRQTYHHGHLHDVLVKRGLEMARSGGTEAVVLREATRRAGVSPNAAYRHFANREALLDEVGLAAADQIGVVMREAVAEAQPIGDEDVAVSQLVAACRAYLDFALTEPGLFDVAYRISDTGLDTLNVDRSKAPNLPDSVIRDVLSDQEVTLSDRVDVRSLVILLWSVLHGFASLSTSGPLRGEGTPERADRVLDIIRASLRGAIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPE4</accession>
    <name>W4TPE4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70074">
        <property type="protein sequence ID" value="GAE70074"/>
        <property type="gene ID" value="JCM18909_3359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="6884" checksum="EDDD1018EA565596" modified="2014-03-19" version="1">MEGLSTVGEGAKTFMKRHLGKNKDGSERELSIGMDVALALGDPAAITITVLMIRCALPSHSLSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPF8</accession>
    <name>W4TPF8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70298">
        <property type="protein sequence ID" value="GAE70298"/>
        <property type="gene ID" value="JCM18909_3606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10675" checksum="AFAB19CD23024C34" modified="2014-03-19" version="1">MRDHTVGRMRAVTVMPVSIGPAASRTLRWQVALAEISSMGSRRVRNCVGLERLVTSMTWACTQMAPQRSTHFDGVDDPRQGARIVGGVRLDHGHYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPW7</accession>
    <name>W4TPW7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70577">
        <property type="protein sequence ID" value="GAE70577"/>
        <property type="gene ID" value="JCM18909_3927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11466" checksum="8A7941C2ED8D0FD6" modified="2014-03-19" version="1">MDGQPADEVVGDLPEIWISSTCPACHARDVPASNDAGTPTARPRDATSAKAARNSSTVLSMYQLPSVLVSAASVVAIRASVRSSTARSRSAMSGRATAVMVCLPSRVLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ76</accession>
    <name>W4TQ76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70379">
        <property type="protein sequence ID" value="GAE70379"/>
        <property type="gene ID" value="JCM18909_3696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6928" checksum="081E1BD839DCA788" modified="2014-03-19" version="1">MGDAVKAAKMADAMLAKGIYVRAFSYPVVPKGKARIRTQMSAGLTREQLDKAIKAFEEARAEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ77</accession>
    <name>W4TQ77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromosomal replication initiator protein DnaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DnaA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70543">
        <property type="protein sequence ID" value="GAE70543"/>
        <property type="gene ID" value="JCM18909_3883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_DnaA_C" evidence="8">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14687" checksum="188E7A314E22EB94" modified="2014-03-19" version="1">MTAFASLNQQPVDISLAEIVLKDLIPEGRETPVTPERIIAETADYFDISADDLLGTSRAQTLVTARQIAMYLCRELTDLSLPKIGAEFGGKDHTTVMHADRKIRASWGSSVRSSIRSLRSPTASNSTELSHSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ82</accession>
    <name>W4TQ82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70548">
        <property type="protein sequence ID" value="GAE70548"/>
        <property type="gene ID" value="JCM18909_3889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10225" checksum="4F974B0F6B36DC55" modified="2014-03-19" version="1">MTDGLDEGPTEEDRRLAADHDDEGVDVAWLLLEPPAVNQQEPRVVTMMVRFCCRHLDVPLRGNAVVAPVPHHGPVLRLMVAIRWPLATLSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQC8</accession>
    <name>W4TQC8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lead, cadmium, zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70608">
        <property type="protein sequence ID" value="GAE70608"/>
        <property type="gene ID" value="JCM18909_3959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="295" mass="30641" checksum="A6573CC5F2DF6577" modified="2014-03-19" version="1">MTLVATLPANGQDVDRAHRYAAALDQHSTHPVAKAVVAAVKGTIPACPSPRTFAGRGVSGEVEGHRVMVGNPAFLTETEIKIPAELSHTVKKAAETGRSAVLVAIDGQAAAALVVADTVKPEAPEVIAQLKDMGLRTVLLTGDSKAAAEAVGTQLGTDEVLAEVLPTDKAEVVERLRSEGRVVAMVGDGINDAAALASSDLGMALVTGTDIAMRSADIICVRHHLGVVPDAIGLSRRTLRTIRGNLAWAFIYNIAAIPIAAAGFLNPLISGLAMSLSSLFVVTHSLRLRNFGTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQM1</accession>
    <name>W4TQM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000075">
        <property type="protein sequence ID" value="GAE70708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70708">
        <property type="protein sequence ID" value="GAE70708"/>
        <property type="gene ID" value="JCM18909_4091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="16563" checksum="0705EBE876BCBCD6" modified="2014-03-19" version="1">MTATIDVGIPLRNADGYPDPTCYQALKEIQLAEYGYRPLVYICSPYSGDIAANVELARRFCAFAVKARQIPLAPHLHYPQFMDDTDRMPGSWRCFFQPHPAVEMRAAVGLYRRVSPGMRAEIDWAHQMDIPIRFFDADFQEVHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDQ0</accession>
    <name>W4TDQ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diaminopimelate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67080">
        <property type="protein sequence ID" value="GAE67080"/>
        <property type="gene ID" value="JCM18909_115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10070" checksum="57C53BB9BD369072" modified="2014-03-19" version="1">MTTFWKGHGTGNDFVIVDQQDPLTSAQVRWLCHRRFGIGADGTLQALRAGDVEDWNGDPDLCSWIIATLIARSLKCVATVCVSSHAISSRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDS8</accession>
    <name>W4TDS8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67115">
        <property type="protein sequence ID" value="GAE67115"/>
        <property type="gene ID" value="JCM18909_154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7586" checksum="0F1D233985D4CECD" modified="2014-03-19" version="1">MGTTMIEHQALTTADRCDRCGAQAYVRITLRNGGELLFCAHHARAHEDKLKQVALHIQDDTTKLSSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE45</accession>
    <name>W4TE45_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67235">
        <property type="protein sequence ID" value="GAE67235"/>
        <property type="gene ID" value="JCM18909_280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF203">
        <property type="entry name" value="PTHR10357:SF203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="113"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="264" mass="29087" checksum="16154846C2F9D99A" modified="2014-03-19" version="1">MRRRPCLINEAVRHAEQSGDTDAITVLREADANLTPDRAPDSLQQVINTYAFCEAMRVHAPRPLTSPTLPAPLRVERRRALYGSWYEFFPRSQGAYVDADGHWVSGTFDTSWERLDAAAAMGFDVVYLPPIHPIGTAFRKGKDNTLTPGPDDPGSPWAIGSSDGGHDTIHPDLGTFDDLDRFVAHAHDLGMEVALDFALQASPDHPWVHQHPEWFTTRVDGTIAYAENPPKKSIRTSTQSTSTMTLTVSTRNACGCWSYGSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE66</accession>
    <name>W4TE66_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67260">
        <property type="protein sequence ID" value="GAE67260"/>
        <property type="gene ID" value="JCM18909_305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="6144" checksum="CA206A228BDAC060" modified="2014-03-19" version="1">MLVILAVSALQHDQYDDRTRKKNDESGNVIESPLSHVMGRIDAQPFNPKKRPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEQ6</accession>
    <name>W4TEQ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67430">
        <property type="protein sequence ID" value="GAE67430"/>
        <property type="gene ID" value="JCM18909_490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14781" checksum="365B9169948D3F9B" modified="2014-03-19" version="1">MVALAGEAEMAEWLVIVVIMVIASGWLARRALRRLLASRRPPAPPCPAWDSASSARDRWSSPRGGCDRSGGWICLTMALAHNGQRLGDHVAGYIMGAAVLGTLGAVMSAHLIIVWCADREQLRLPKVSGWPWLGLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEV4</accession>
    <name>W4TEV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg/Co/Ni transporter MgtE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67485">
        <property type="protein sequence ID" value="GAE67485"/>
        <property type="gene ID" value="JCM18909_547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="282"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="351"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="421" mass="46704" checksum="50F99D0EDCD79ECA" modified="2014-03-19" version="1">MNRSQSVFISRIRGLPVMDASGDQVGKVKDVVVQMRTPGRAPLVRGLVVELFARRRIFVPMVRVHAIDAVQIMISGTVNTRVFSRRVSETLVIEDLFDRTFHRNGTPVWVMDVSMAPVRSREWEINEVALAESGRSRFIRKAPSNPTIVDWREVPSLVLASRQSTERTIAEMHEMKPADMARELHDMNPHRRAEVAMALDDDQLANAIEELPEDEQVSLITILDPDRAADILEEMDPDDAADLIKELPDTTAHQLLARMEPDDADDVRSLMAYDEFTAGAMMTPEPVIVAADATVADALALVRNEDITPAEASMVFVCRPPTETPTGRYLGAVHVQRLLREPPSTMVSAIIDSDLEPMHTDAPVGAVSRYFATYNLVVVPVVNDANQLVGAVAVDDLLDHLLPTDWRGDQMDGELVEVNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEW4</accession>
    <name>W4TEW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67331">
        <property type="protein sequence ID" value="GAE67331"/>
        <property type="gene ID" value="JCM18909_378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6414" checksum="A3F3B096D7267B16" modified="2014-03-19" version="1">MCKGVRLTGVVRMFSGRGLHSERISNVAMGYMKKTVLFLSLVVSFRQKSCPSCDGMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEY3</accession>
    <name>W4TEY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SOS-response repressor and protease LexA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67087">
        <property type="protein sequence ID" value="GAE67087"/>
        <property type="gene ID" value="JCM18909_122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9505" checksum="2B5C2FAC83311FA0" modified="2014-03-19" version="1">MIIVRDDGMSPDIHSGDLVVVRRISVSDLPDDPPETYLVAATAGGTTVVRTLSNVSGQRWLLASNPTHSPINLDDASLLGQAVSLLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF59</accession>
    <name>W4TF59_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67600">
        <property type="protein sequence ID" value="GAE67600"/>
        <property type="gene ID" value="JCM18909_673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849216" evidence="2">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6185" checksum="5A9504BCD5D9EC9F" modified="2014-03-19" version="1">MKKNWLLTTLLTTVMIAMGTTTTAVASPPTDITPEHPGGVTAPHSPEGIPSNNEGPSMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF97</accession>
    <name>W4TF97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67431">
        <property type="protein sequence ID" value="GAE67431"/>
        <property type="gene ID" value="JCM18909_491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="6969" checksum="E4924C4E5B60A519" modified="2014-03-19" version="1">MALARAHYLDSAAMVIALTIMVGLAGFGSGFLISGTHDTAGTPTMSSSRSPSPTGPPPNSKPSGASPGPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFF0</accession>
    <name>W4TFF0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67695">
        <property type="protein sequence ID" value="GAE67695"/>
        <property type="gene ID" value="JCM18909_773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6773" checksum="62CC4732FB29F166" modified="2014-03-19" version="1">MVGPLHWDRPQHVDVDWPGDLVSLPPVMDETTIDQVIDVATMVVEGTRFSWKDRDLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFG4</accession>
    <name>W4TFG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67267">
        <property type="protein sequence ID" value="GAE67267"/>
        <property type="gene ID" value="JCM18909_313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="46"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="249" mass="26914" checksum="F950227395A2398D" modified="2014-03-19" version="1">MRDGVCRRLNRAPVTIKNVEVAIIDKAWEDRRVIPVVPEWHSLKTAAVVGSGPAGLATAQQLTRAGHTVVVYERDDAIGGLLRYGIPDFKMEKSVLDRRIKQMVLEGTVFKTNTEIGVDITGEQLRERFDAVVLATGATVLRMLDAPGIELDGVCYAMEYLTQQNRVVAGAEVLDQIHAGGKHVVIIGGGDTATDCVGTAVRQGAASITQLQYNPEPPKDDRLTIPGPLIRSFYGSLAPMRRGTAGVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFJ2</accession>
    <name>W4TFJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67203">
        <property type="protein sequence ID" value="GAE67203"/>
        <property type="gene ID" value="JCM18909_246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="584" mass="63783" checksum="9954FABE656A5D25" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFM4</accession>
    <name>W4TFM4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67238">
        <property type="protein sequence ID" value="GAE67238"/>
        <property type="gene ID" value="JCM18909_283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="15"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="347" mass="36260" checksum="7209F7C01D5AA5F4" modified="2014-03-19" version="1">MSQLKPGSVHHDRAYFDHAATSPLRREAREAMACTVPGNPGAIHGSGRAARALLEDAREEIASLLGVGPLEIVFTSGGTESDMLAVMGAVRDGRALVSAVEHPAVGGLVSPWLLGKRCELLPVNHAGLVDPDEVGGHTGNLDVVSVMAVNNETGACQPVSRVAEAAHQAGALMHTDAVQALGHIPVDLDGWGVDLASFSAHKIGGPVGIGALWVKRGVKLHPVSPGGGQQYGIRSGTQPVALACGFAAALRACVDEFDTMTARWQSWRQRVIAWCRQQPEVTVDDAPMTSPSIIHLSVAGTRGTDLVMLADRDGVDLSAGSACHAGVSRPSPTMLAMVETTMLRPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFM9</accession>
    <name>W4TFM9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MTS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67581">
        <property type="protein sequence ID" value="GAE67581"/>
        <property type="gene ID" value="JCM18909_652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19184" checksum="8C38A126A9B5590B" modified="2014-03-19" version="1">MTMTTACGVFSGTRLDPGTAVLMRSVTPPPSDGTFLDLGCGYGPIACALARACPGSHIVAVDVNDLAIDLTTRNAKALRVGDRVHACHPEKVDPDLRFDEIWSNPPIRVGKAALHEILTTWLARLSDEGVAHLVVGKKPRRRLSHQLAVRARIRRGPSRFRERIPGHRRPCLTWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFN8</accession>
    <name>W4TFN8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67591">
        <property type="protein sequence ID" value="GAE67591"/>
        <property type="gene ID" value="JCM18909_663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="286" mass="30195" checksum="20F030912946D0B4" modified="2014-03-19" version="1">MPVPIREGHPYDLTVTAGHGLGLSYRGHTHDSWAAPVTLDDIVVERKRSGFHMRNLTSPDWYGLQIMWKGTDGTSRKLTTIRRGGSVRGGWGTAPTTDDPTAFHSFPSSQGTLVMKVTDYAGNTTIQHFAVKNNDLVRPATAPRFTVVGPARQRVTVSHPITPVRISVSGDQPVSWRLRGALPAGLRWTNDMSVNGLTSLAATLSGSPRSAGNHRIVVEASDLFGNTVTRSVVVEAARGSAPSSFGGSSGPSASASADSAIRPGRDSSSPASSGSTRPVRMPLTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFP7</accession>
    <name>W4TFP7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67352">
        <property type="protein sequence ID" value="GAE67352"/>
        <property type="gene ID" value="JCM18909_401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041678">
        <property type="entry name" value="TetR_C_16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17920">
        <property type="entry name" value="TetR_C_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="TetR_C_16" evidence="2">
        <location>
            <begin position="81"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="21958" checksum="F151F61FBABF81D1" modified="2014-03-19" version="1">MVHVVRLGLREPQFWPQPGPFFLAGDFQSVSLRAIAREAEVDTSLVSYYFGSKQSLYNEAMSLPNGPHRIIAEVCSRTDPDHLGEALVKAFIDAWDGHLGLGGPDPQMQGVVQALLTQPDAFDMMRQFYTEEILAPVVNLLIPRFGAEEAGIRASLGLSQLLGIFTARYVVGLQSLANLPAAELIGREGPALQSTLTGPAING</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT9</accession>
    <name>W4TFT9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67835">
        <property type="protein sequence ID" value="GAE67835"/>
        <property type="gene ID" value="JCM18909_922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="12977" checksum="09DF265384ED8BBA" modified="2014-03-19" version="1">MEVPAPGEVPEPAVGSAAATLVSSTGEVTHLYGPVLIGRAPRGDNGEDTMRVPSLGQDISRTHVRVAPGQWGIEVTDMHSTNGTVVCRIGQEPLQLESGQMVDLSIGDSVDLGDGVVITIEAYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG05</accession>
    <name>W4TG05_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67442">
        <property type="protein sequence ID" value="GAE67442"/>
        <property type="gene ID" value="JCM18909_503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30829" checksum="BF8336BDF652DFF9" modified="2014-03-19" version="1">MSHPEVDRVILTGAWETAKLFRSWRHDLPVLAETSGKNSIIVTENADYDLAAADIIKSAFGNAGQKCSAASLIILVGQAYRSQRLRHQILDAASSIRVGSPSDLRSQMGPLAEPANGKLLDGLTKLDPGQEWALEPVRIDEEGRCWSPGVRGGIKPGDPYHLTEYFGPITGIMYAPDLATAIEYQNGTAFGLTAGLHSLDLAEIEFWAERANAGNLYVNRSITGAIVGRQPFGGWKRSAVGPGAKLVATTTYRCWGLGVELRCRPRLRQTVPVLWSSSSSVISRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG60</accession>
    <name>W4TG60_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67517">
        <property type="protein sequence ID" value="GAE67517"/>
        <property type="gene ID" value="JCM18909_581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="6">
        <location>
            <begin position="25"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="7">
        <location>
            <begin position="290"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="440" mass="47090" checksum="18212170463FDE50" modified="2014-03-19" version="1">MTSTDPHDYRNDIRHDREFVNDTEAVIRLGSMLLSSGTGSYRVKRAMSDAGLTLGIDRLDASVSLTEITATAHRGDNFRTVAREVYRVRVDSSRIAALEDLAHNLLAGTTGRELESRLDYISRTVRPKWAEWQTVLAGGIACAGFAILNKFSLADSLVVLAAASVGQFVRGRLNRRWLNQFGIAALASAAACLIYLMLADLLTNTGLHTIHGPGYVASLLFLVPGFPMITSILDMVRMDFTAGLSRATYSVGLILAATMSAWVFSAATGLQPLPAQTVFPYPWAWFAYTVATACGVAGFAILFNSSPCTVAWAAALGACGNLCRLALVGVNLPAQLAAGVGGIVIGFLASPLSVRTKLPRITLTVPACVIMVPGASMYRTVYWLNGQDMTKALTFGVDAVLTVILIACGLAVARMCTDPAWARNLPVPSPHAFKFSEDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC9</accession>
    <name>W4TGC9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Porphobilinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68010">
        <property type="protein sequence ID" value="GAE68010"/>
        <property type="gene ID" value="JCM18909_1116"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8861" checksum="61FB269C5B9F6D79" modified="2014-03-19" version="1">MVKPASHYLDVLSDVAEVSQVPVAAYQVSGEYAMLEAAAANGWIDRRRCIGESLTSIVRAGADLVLTYWAIEAAQMFREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD9</accession>
    <name>W4TGD9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7 8">Pantothenate kinase</fullName>
            <ecNumber evidence="4 7 8">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coaA</name>
        <name evidence="10" type="ORF">JCM18909_670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7 8">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4 7 8"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67597">
        <property type="protein sequence ID" value="GAE67597"/>
        <property type="gene ID" value="JCM18909_670"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7 8" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="9">
        <location>
            <begin position="100"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="327" mass="36962" checksum="FDCFCCFCAF4DA8BF" modified="2014-03-19" version="1">MNLTPTTPVDDDNTEPGPFIELSRESWAALSDSTEIDIDEATLDHIRGLGDPTSHRDVVEVYRPLTQLIHLYCMHTGALFDASNNFLQLTRHGMKRTPFVIGIAGSVAVGKSTVARLLRELLGRSPRRPVVDLVTTDGFLYPNRVLEERELLSRKGFPESYDRKALLRFVVDVKSGMPEVTAPVYSHVTYDIVPNQQLVVRQPDILVIEGLNVLQPPRRRSSGTMGLALSDFFDFSVYVDAEEADIIRWYINRFLTLRQTAFTDPHSFFGEYARMPDNEAITIAKEIWDTINGPNLVQNVLPTRGRATAILHKGPDHEVRNVWIRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE4</accession>
    <name>W4TGE4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67602">
        <property type="protein sequence ID" value="GAE67602"/>
        <property type="gene ID" value="JCM18909_675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5429" checksum="412A8491FEBD1C2B" modified="2014-03-19" version="1">MSLSAACAWAAEMVAKAVATMVVSEVRAAAILFDLFMFSPYASMQDVSLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG1</accession>
    <name>W4TGG1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67871">
        <property type="protein sequence ID" value="GAE67871"/>
        <property type="gene ID" value="JCM18909_962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14783" checksum="F33D9707B1F937AB" modified="2014-03-19" version="1">MEDVIEVEGDVAMTATNARAQQTERMGTAPGFIAALDQSGGSTPKALKAYGVEPEVYGDDKDKMFDLVHEMRTRIITSPSFTGDHILAAILFEMTMDREIEGIPTGDYLWEKKGIVPILKIDKAWLTRTATFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK2</accession>
    <name>W4TGK2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="5">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">truB</name>
        <name evidence="8" type="ORF">JCM18909_1204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68090">
        <property type="protein sequence ID" value="GAE68090"/>
        <property type="gene ID" value="JCM18909_1204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="6">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="7">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="295" mass="31142" checksum="F7DD0F0646A23321" modified="2014-03-19" version="1">MNTLQSGVLVVDKPAGVTSHQVVGRVRRLMGTRKVGHAGTLDPMASGVLVVGVNRATRLLGHLSLHDKDYTATMRLGVGTVTDDAEGDVTVTTDASAIDDRAIHAAMARQTGEIQQIPAAVSAIKVNGRRAYAKVRAGEGVVLRPRAVTVSRFEAIAIRRHGQVIDVDVEVTCSSGTYVRALARDIGADLGVGGHLTALRRTRVGPFDLTAACVDIFAQDAVTPIPMTMAEAAALSFPVVHVTADQVAAIRVGRRLDFTVPAEVTAIIAETGELLALYRPDDEKDGQSRAICVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR2</accession>
    <name>W4TGR2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67613">
        <property type="protein sequence ID" value="GAE67613"/>
        <property type="gene ID" value="JCM18909_686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="286" mass="29706" checksum="DDA1939510F09061" modified="2014-03-19" version="1">MSGNYLIFFTSSDSAGTCSKVNDDLGSDPLDSDACTTREQLLSKEFAPLSGKKIVEQYLAWFLVAGLGAGLAAAAATTSARRIIAPLTAMGVPRRKLALSLRVVTLFMSMATAAASLVTGELLVIAIRPLLARFSDNPLSPVSSPTMSAVTCLGAAIVTAVVMVTPSSQRERKVHGKRINVKMARLLAWSGAIVACALLVWASVAAKASLISVAIVSALSSLAAGLVAPWLLALVSGRDVSPGRRLAASRAFALGVHGTDCSQGSRQGLLPLLLQVCLLSPHCSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS0</accession>
    <name>W4TGS0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activator of (R)-2-hydroxyglutaryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67349">
        <property type="protein sequence ID" value="GAE67349"/>
        <property type="gene ID" value="JCM18909_398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27280" checksum="20D378F0172BBE00" modified="2014-03-19" version="1">MKATHTILVPQLAPYQTSVAEAALRASGYRVEVLKQASRENIDYGLSVVNNDACFPAIVVIGQLVSALKSGKYDLDHTTLLLTQTGGMCRATNYIGLLRKALKDAGFGNIPVIAASLQGVEDNPGFSLTAPLIHRMVQAITIGDLLQKVHLRTRPYAAVPGSADDLMHRWTTIAREHFLNGGHSPTWGRRTSYKAMINGIVDDFEHLELIDGPRKPRVGVLGEILVQFHPDANNHIVETIESEGCEAVLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGV0</accession>
    <name>W4TGV0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67991">
        <property type="protein sequence ID" value="GAE67991"/>
        <property type="gene ID" value="JCM18909_1095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="23281" checksum="6AAE4CAC49FD12B8" modified="2014-03-19" version="1">MAMLPVRVLLVDDDTLVRRAVRQILEAADDLEVVGEASDGDGAVRQAPQADVVLMDLRMPGMSGVEATSRITHSPSSPKVVVLTTVTTDAAITDAIHAGALGFLLKASSPEDIVSAVRAAHAGDAFMSPTSTRQLLEQLRSDTGRRDHRAARKTLSALTDREREVAIAVAKGLTNDAIAARLNVSASTVKAHLSTIQTKLDVDSRVRIAVLVERAGYLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH25</accession>
    <name>W4TH25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphomannomutase PmmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67733">
        <property type="protein sequence ID" value="GAE67733"/>
        <property type="gene ID" value="JCM18909_813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="60"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="263" mass="27472" checksum="AF021989F8E020A8" modified="2014-03-19" version="1">MTTTRPERPSPELIAEVQSWLGQDPDEVTRTELSDVLVRAQSGEAEAIAAVESAFAGPLTFGTAGLRAALGPGPSRMNRVVVQRAAAGFAAWLRSHGSRGGTVIIGFDARHNSDVFARDTAEIMAGAGFHALLADSPIPTPVTAFAIKHYGAVAGVMVTASHNPPADNGYKVYLGDGSQIVPPTDAEIAHEIEVVSEEPVGAIARGDDIEFIGDELIDAYVCRAAELTTANPDVTWCIPPCTGSEHGSCVVSSRRLACPNLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA2</accession>
    <name>W4THA2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome d ubiquinol oxidase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_1469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68340">
        <property type="protein sequence ID" value="GAE68340"/>
        <property type="gene ID" value="JCM18909_1469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE68340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="506" mass="55968" checksum="0A5C4A23713562BE" modified="2014-03-19" version="1">MDAQLIARWQFGITTVYHFFFVPITIALSMLVAVMQTVWLKTRNDRYLRLTKFYGKLFLINFALGVVTGIVQEFQFGMNWSEYSRFVGDIFGAPLALEALVAFFMESTFVGLWVFGWEKLPKGVHLACIYLTAIGTMISAVFILAANSWMQNPVGASYNPVTHRAELTDFGAVLSNPVFKATFVHQISSSYTVAGALIAAIAFWHLAKVARGRATSQISDAEEVESVRTWRWASKFGAWVLIVACVGVVLSGDYQGKVMTDAQPMKMAAAEAAYQNTSDFSVLTIGNKDGSEEVWALKIPGMLGFLGNGKWGSQVKGINELKSYQVHEYTYHRKDGSQTSLQASYQNVLRQKIDANGIKLEPNVPLSYWTFRIMITLGMIGGLIGLVMLIAMRGGRNPKPHRWLTFFMIALPLLPLFAISFGWIFTEMGRQPWIVAGVLPTTAAVSPNVSAGSVLFSTIAYTVVYGILAVVEVGLFWKALKEGLPELSTRDQPVTEGEDTPLSFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD9</accession>
    <name>W4THD9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67569">
        <property type="protein sequence ID" value="GAE67569"/>
        <property type="gene ID" value="JCM18909_639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12672" checksum="EA77799CB702E32B" modified="2014-03-19" version="1">MAVYTLPDLDYDYGALEPHISGKIMELHHDKHHNTYVQGANTALEKLAEAREKSDFGTINKLEKDLAFNLGGHINHSVFWKNMSPHGGGRPEGNELAAAIDEFFGSFDSFKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE4</accession>
    <name>W4THE4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhs-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68380">
        <property type="protein sequence ID" value="GAE68380"/>
        <property type="gene ID" value="JCM18909_1514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="489" mass="53490" checksum="0C4B778F5632126D" modified="2014-03-19" version="1">MIIDDEQVRWVRDDGREIVFPLTDHDGASGSAAAEGCHTVAGAWRAVQDNVWISRSDVADLAVQAADVAGPVWIVADNTGNRWVFTTEGAWVASGSGAGDGVWIERHDGVITSMHSEWGRSVDLFYAQGRLAKAVASDGRSVSYAYDPQGRLVDVTRPDGVHHYQWDGWLLSQVIDASGVAQCENTFDALGRIRTQRDATGHLTRFTYLPGGVTVADDGQGHHSNTWISDARGRTVGIIDADGQRTSMRYDRYGNLVGATDRAGKVIRHTYNERGHRTSTTLPTGGVIEYGWDEADRLTTISTAGTLRARLDYDGTQLTPVRLADPHGTTVTMSWDRGLLRHLTDATGASISVDYDEYGQIMAITNGVGATWQISHDEAGQISQILTPLGYRTEMTYDQAGRLVERIDPDGACWSYDYDEAGHLETAAAPDGGCIRYTWGPDGQITTITDQLAPRRHWRMTRWGIWRGSVYPTGPAGDSCVTRWPGCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI7</accession>
    <name>W4THI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67898">
        <property type="protein sequence ID" value="GAE67898"/>
        <property type="gene ID" value="JCM18909_991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12842" checksum="873FC77E1A8AC43C" modified="2014-03-19" version="1">MATYFTEAISTPDTIDSYRVQGLVAPDTDWDSHSKKAEAWGHAIFKAYNDDKAGLNEGILISDGPLPTRSADIYSRSTGEPIMTVVMVPVMENCRRLEHHGASQQFPAPTTTITPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL9</accession>
    <name>W4THL9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator MtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68430">
        <property type="protein sequence ID" value="GAE68430"/>
        <property type="gene ID" value="JCM18909_1568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="6294" checksum="3877FCC4BD4B29ED" modified="2014-03-19" version="1">MREVWGYTNITDTRLVNVHVQRLRSKVERNADHPQMIVTVRGIGYRINTPGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN0</accession>
    <name>W4THN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exported protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67918">
        <property type="protein sequence ID" value="GAE67918"/>
        <property type="gene ID" value="JCM18909_1016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_4" evidence="2">
        <location>
            <begin position="103"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="197" mass="20866" checksum="AF4C644F693CCF9C" modified="2014-03-19" version="1">MKVTGRELTQSLAATGIALFLYSGKQAYSYLTAALVGAMKDGNGGYLLMASDYLNGRGKDGQWETIASAFPAISCLDQADFGLKHARQEWPQEVAKAPTLGKALGVAPVCEVWTARPAPQLYLTARGAAPILVLGATGDPATPYEQATWMAGQLKSGVLLTWRGSGHSAWELGNQCVKKAVEGYVNDGKTPKDNTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN1</accession>
    <name>W4THN1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate-flavodoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68306">
        <property type="protein sequence ID" value="GAE68306"/>
        <property type="gene ID" value="JCM18909_1434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="419" mass="45777" checksum="DA123416A9846684" modified="2014-03-19" version="1">MKFFETIPVNDRSRVDFATVRGTQFLEPLFEFSGACSGCGETPYVKLITQLFGDRAEVANATGCSSIYGGNLPTTPWGKNASGRGPAWSNSLFEDNAEFGLGMRMAANVQTELARRRLQEVSSQLDPEFVEDLLHAPQLTEHDLQSQQHRVKELQTKLANMEQTPAVRDLMSVADHLLRRSVWIIGGDGWAYDIGSGGVDHVLASGRDVNILVLDTEVYSNTGGQASKSTPLGAVAKFASLANPPPKKRHGPASHRLRVGVRRPRGPGRRSAANPAGLPRGRGLPWSEPHHRLQPLHRPRLRPAKRPGPAVQGGPLWTLAADALQPGASRRRAQPIPARLPQTRRDVAGVHQARAALPDAPEGPSGRGRTYAGPGPAPGRASLRRVCRNGIPHRRGLRRRCPYVRVRRFIQPRLTATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ7</accession>
    <name>W4THQ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AsnC-family transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68470">
        <property type="protein sequence ID" value="GAE68470"/>
        <property type="gene ID" value="JCM18909_1610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9344" checksum="A5A12D2926A097C4" modified="2014-03-19" version="1">MYEELDRRLVNVLQIDPRASWAKVGKVLGVSPTTVAHRWQRLVDDGIAWITACPNLNQQMTAIVEVDCHTESFPPSHQDTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI03</accession>
    <name>W4TI03_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68058">
        <property type="protein sequence ID" value="GAE68058"/>
        <property type="gene ID" value="JCM18909_1167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14974" checksum="FA3813E2251348E0" modified="2014-03-19" version="1">MWVTAAWHDHSQTWSIINVASTAAFQPIPQFATYAASKSFVLSFTRALWAETNGTGVRATAICPGPTETGFFDVAGVPRMAAGARRNPDDVVRTAFDALARHRPYAVDGFVNRTVARLAPHLPARLVMTQAEKYLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI04</accession>
    <name>W4TI04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67799">
        <property type="protein sequence ID" value="GAE67799"/>
        <property type="gene ID" value="JCM18909_884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="357" mass="40473" checksum="1CC56210362C372C" modified="2014-03-19" version="1">MKEAMLNFDERTGPNQGVNAPHWPSTRVPQWWKDAKLGFFTHWGLYSVPAWATTNPDPVPLEQEYAHHCYAEWYANTVRILDSPTRQHHDRVYGIGTSYEDFADWWTPDLDAPATLIRRIADAGAGYVIPTTKHHDGFCLWDTDTTGFNAAKRGPHRDLVKALHDEARAAGLRFGVYYSGALDWHVGDFGAITSDTELFTFRRNDPDFAKYCAAQLTELIARFRPDILWNDIEWPDAGKGRQPYGLASLFSYYLKQVPEGVVNDRWGVSHHGFLTREYRHVDAKINEPWESTRGLGCSFGYNQEESTDESLSGTELVRYLVDVVAKKTEICSLTSGHALTALFLRCRPPQWLNSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI70</accession>
    <name>W4TI70_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68655">
        <property type="protein sequence ID" value="GAE68655"/>
        <property type="gene ID" value="JCM18909_1806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24242" checksum="C7C4584E3FF2DB95" modified="2014-03-19" version="1">MQWRMIGRRGRQASWTIVGDPAQSAFPHPNQTRAALDELVGNSPSRTFTLTKNYRSPAEVFDLAADVVVTVQPGADLPQAVRWVGVRPTVVRTDDLWAQVRSQLDGMLTSVDGTIGLVCPAGLVEQARRLADDPRIITVTTMQAKGLEYDGAVVVDPERIVSETGNPSGGVRLLYVALTRPTQRLAVVGLRKQKSPHRSEANQPVQGAAAPAWSEALWSHETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB7</accession>
    <name>W4TIB7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68277">
        <property type="protein sequence ID" value="GAE68277"/>
        <property type="gene ID" value="JCM18909_1401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Molybdopterin" evidence="1">
        <location>
            <begin position="121"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="329" mass="34458" checksum="21D41574F18670BB" modified="2014-03-19" version="1">MIYLRLRKAWRRHKATITVVGTHLSNGSAKIGAELARCLPGQEPEALAQLVADGTIGEGTIVLVGERAATRPGTLSAINDLDSTVRVAWVPRRAGEMGAIEAGLLPQLLPGGRLVDDAKARVDIAAAWGVTNLPTQPGLDTAGMLAAAQAGKLDALVVSGVELADMPDPTGAREAVENCGFVVSVEQRFSEVSARADVVLPVCLLEETSGTFLDWEHRPGRVRVVNKQPATPMNEIRVLDALSSQMGSVSGLATVAQAHKAWRDLGQWSGGHPKMESTSPLVPQAPMVEAGSVGRVLETWRQLLEGSASLTGADALVATAPAPVASSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP1</accession>
    <name>W4TIP1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Guanyl-specific ribonuclease Sa3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68651">
        <property type="protein sequence ID" value="GAE68651"/>
        <property type="gene ID" value="JCM18909_1801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7111" checksum="35061A5CD1599EE6" modified="2014-03-19" version="1">MGWPPSRKTSFLQARQTLKLIDSGWPFPFSRDGIVYHNNSGALPHHKDGWYHEYTVATPGAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP8</accession>
    <name>W4TIP8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68303">
        <property type="protein sequence ID" value="GAE68303"/>
        <property type="gene ID" value="JCM18909_1431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7937" checksum="1448166E1E626F6A" modified="2014-03-19" version="1">MTDSGSGRSWRSDRFPELVAGTFRMTSSRGDHVTASRTSIAAQPAGSTPRLCGSALAIGYRYLPERWCGISVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ34</accession>
    <name>W4TJ34_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68174">
        <property type="protein sequence ID" value="GAE68174"/>
        <property type="gene ID" value="JCM18909_1293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="90"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="18765" checksum="7EA51288EA703377" modified="2014-03-19" version="1">MPGPLPAMTAQSQHRFDTAIGELEVTATAHGLSRLVFVKTDPSPLLPPLSTSHAHRSGDIISCAIAQITEYLSGSRTSFDVALDLSAMTDFQRAVLTGLQTVPYGQTVSYRQLASIIGRPNASRAVGHACATNPLPILIPCHRVLRSNGQLGGYLGGPRLKRFLLNLEGVTSAPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ49</accession>
    <name>W4TJ49_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68816">
        <property type="protein sequence ID" value="GAE68816"/>
        <property type="gene ID" value="JCM18909_1980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="613" mass="64160" checksum="C5CA4774567D16B1" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ76</accession>
    <name>W4TJ76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68453">
        <property type="protein sequence ID" value="GAE68453"/>
        <property type="gene ID" value="JCM18909_1591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9490" checksum="5551AEF548262C10" modified="2014-03-19" version="1">MMTHTTQRSHEDNPQGPKASATRDDPRAATIEQIQPIVDRGDQGYAETLTNRQVQMMAIGGAIGVGLFLGAGSRLRSAGPAVSSPTRSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA9</accession>
    <name>W4TJA9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68871">
        <property type="protein sequence ID" value="GAE68871"/>
        <property type="gene ID" value="JCM18909_2041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24602" checksum="E31C17AB6AAA9660" modified="2014-03-19" version="1">MGMGYDPVTMSTPSTHDGNHGSIRPLQKAIRALSETLDAMSGLLDQAWVERAQNLCLRVMGLDPGHISIHNLSREYYQLLEEITAAARSPRLTVDPDQPARPTMKRVLRKSVADAVAKCDDVEDVQGWSTAEVAVRHAAAVAGILDTGRAGKVAKRLRPVVKEIAQTKRSVTEAVDVSQMSPQEAFEAGREVERASASLFAARQSFRDDWQQHRRKILKAIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE7</accession>
    <name>W4TJE7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69075">
        <property type="protein sequence ID" value="GAE69075"/>
        <property type="gene ID" value="JCM18909_2259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8273" checksum="B9B2DA2492BB1430" modified="2014-03-19" version="1">MALTINDLIAKEIDFRGSFGMPAVEFRYLLNQVAAGKMKPGQLVTKTIALSEVNDALTAMSTYNTVGTTVITDFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJF0</accession>
    <name>W4TJF0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FCD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68667">
        <property type="protein sequence ID" value="GAE68667"/>
        <property type="gene ID" value="JCM18909_1818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="4">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5807" checksum="5B3EB3D0DE42CCF9" modified="2014-03-19" version="1">MISWISELRSAVEPLAVELAAKRATREEVTTMALAVTGMIAAAADRDLDEYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI0</accession>
    <name>W4TJI0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68578">
        <property type="protein sequence ID" value="GAE68578"/>
        <property type="gene ID" value="JCM18909_1725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8732" checksum="22D44616F377F41A" modified="2014-03-19" version="1">MLLAQCADAGVKPLLEGPDWGLLDRRSAIGGQVLRIQTASGPLGELFLPVFLASIWPTMLLRRWQLWKLSLGRLSRNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ9</accession>
    <name>W4TJJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maleylpyruvate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68598">
        <property type="protein sequence ID" value="GAE68598"/>
        <property type="gene ID" value="JCM18909_1745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23126" checksum="5C306CF697A8D289" modified="2014-03-19" version="1">MGLSDDEWQAPSRLAGWTRAHIATHIARNAEAFEAVTKAVITNQKVPHLYPSDELRDRDIERGSERAGLQLQIDLDTTAGSLNTTFDALDDMEPGTAVWLTNDIRVDVTDLPALRLAEIALHHVDLDLGMTVDDLPDVSARTLLEWVCFRLRDRPEVPAMRIVSDSGLTDRIGGVGFATTVHGPDGALAGWLSGRGGTERLAGADQLAVPMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK8</accession>
    <name>W4TJK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68608">
        <property type="protein sequence ID" value="GAE68608"/>
        <property type="gene ID" value="JCM18909_1755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9592" checksum="A74261746BDA4D9F" modified="2014-03-19" version="1">MELKLLSLAGNENVLSSQLAPLLVDHDPCIITFRTFKKMRISSALHPMQPAVDSGLHQVDQPKLARYSCLHWQPPQPQPQAELHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS5</accession>
    <name>W4TJS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="T01.980"/>
    <dbReference type="EnsemblBacteria" id="GAE69205">
        <property type="protein sequence ID" value="GAE69205"/>
        <property type="gene ID" value="JCM18909_2398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="174" mass="18585" checksum="95FA46A862012D5C" modified="2014-03-19" version="1">MIRLFQAEVDHLEKIQGQRISMDGRAVRLSSLVRSHGTMMAQGLAVTPLLAGWDELAHRGRIFSYDGTGGQTEEHSHACVGSGALFANDVLNEGYRIGMDRDESVALAIRALDTAISDDSPSSLSGPDLSRGLYPTVACADSHGVTRVPTEEVAVLAKRLANQVTAESGPEEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT9</accession>
    <name>W4TJT9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69220">
        <property type="protein sequence ID" value="GAE69220"/>
        <property type="gene ID" value="JCM18909_2414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849115" evidence="2">
        <location>
            <begin position="36"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="21980" checksum="D6DD70C67EEA6B6A" modified="2014-03-19" version="1">MTTTLMKTCLLGMAGAMAVSLVACGNNSSSNGTPASTSVARSSTSVTASPTPVEHEQTKALKHLSQDDFTKAISSKKINNQTFTIVDNSQIAAQMNQITKVMSQAKISPAECGKILKQSISSVTGGELNNIISAIGSDQSAPTTVTFNTAMSSRQKKSFETEDKQFSKCGHVAMDLQGHKTTMTMKLTPIKGYEDISKKRHPFTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK68</accession>
    <name>W4TK68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal large subunit pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68534">
        <property type="protein sequence ID" value="GAE68534"/>
        <property type="gene ID" value="JCM18909_1679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="271" mass="31005" checksum="BBCCFE8612034A39" modified="2014-03-19" version="1">MGGQRVDEMLDEGRFVDESGRTFRRDSPFTPQTFVFFHRDLPTETPVPAGIGILYSDERILVVDKPHFLSSIPRGCHVLESVVVRLRTQLGLPELTVAHRLDRVAAGVLLLTRERKWRRPYQEIFERREVVKKSIGWWHPWCTIQLGKGLPRQKSGWQVRSRIIKEREILQAREVPGVPNAVTDIALIGEHGGWGLYEASPRTGRTHQIRLHMQRLGAPIVNDPFYPVVLDTPVDDFTHPLQLQAWRMGFTDPVSGDPRAFTSRLGLAAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK97</accession>
    <name>W4TK97_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68569">
        <property type="protein sequence ID" value="GAE68569"/>
        <property type="gene ID" value="JCM18909_1716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9444" checksum="DE65A06063805202" modified="2014-03-19" version="1">MGDVVEIDKVADEAGSSIELTPLLVVDGESVTSDKDALGKVKVTAEVLGETKGPKIRILKYKNKTGYKKRQGHRQKYTQVKVTGIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB1</accession>
    <name>W4TKB1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-serine dehydratase</fullName>
            <ecNumber evidence="9">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_2123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="9"/>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68947">
        <property type="protein sequence ID" value="GAE68947"/>
        <property type="gene ID" value="JCM18909_2123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004644">
        <property type="entry name" value="Fe-S_L-Ser_mono"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00720">
        <property type="entry name" value="sda_mono"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_beta" evidence="11">
        <location>
            <begin position="4"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="10">
        <location>
            <begin position="191"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE68947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="309" mass="33329" checksum="28949293801FA3EC" modified="2014-03-19" version="1">MAVSVFDIFKVGIGPSSSHTVGPMRAARIFVTDLAQSPVWPEVTRVRAELFGSLGATGHGHGSEAAVLLGLEGEDPATVDTDQTPARAASIANDGRITLDAVHGGREISFAVTTDLVLHRNRSLPFHPNGMTFTAWSGQEVVVERTFYSIGGGFVVEHGEDEHPAIVRDSAPVPYPFKTGKELLEQCSDYRMSIPEVAMANEMTLRTEEEIRGQLLDIWAVMHACVERGCSRAGVLPGGLHVRRRAMKMHHDLVTRERIAPGKPEPFGSVDWLTVWALAVNEENAAGGRIVTAPTNGAAGIIRPACILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ0</accession>
    <name>W4TKQ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoenolpyruvate-protein phosphotransferase of PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68993">
        <property type="protein sequence ID" value="GAE68993"/>
        <property type="gene ID" value="JCM18909_2172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilizers" evidence="2">
        <location>
            <begin position="48"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="226" mass="23821" checksum="72AB4232D031F42E" modified="2014-03-19" version="1">MWAAFDDFCAQLSAAGGYLAERVTDLRNVRDRAVAVMQGLPEPGVPSFDSPVILVAEDLAPADTATLNPELVRGLITAAGGPTSHTAILASQIGIPAVVRCSEARDIEDGTPLALDGVTGTVLVEPDEASVSELTERANRRAEVLASALTGTPHCLTANASSYSPTSATLPTPPRRRRKAPRESACSAPSSSSWTGKTPPLLTSKLRRTPPYLRPLMRAPRLSFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ3</accession>
    <name>W4TKQ3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Trigger factor</fullName>
            <shortName evidence="6">TF</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tig</name>
        <name evidence="10" type="ORF">JCM18909_2575</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 8">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69366">
        <property type="protein sequence ID" value="GAE69366"/>
        <property type="gene ID" value="JCM18909_2575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="162"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="375" mass="41202" checksum="887FE0A62AD4126C" modified="2014-03-19" version="1">MPSSLEKLSTNRVKLTIEMPFDELKPSLDKAYKNIANQVNVPGFRKGKVPAPVIDQRFGRGVVLQEAINDALPAAYGKAIEENTVVPLGQPEIEVTKLEDGEVVEFTAEVDVRPDFDLPDVSAISVEVPAVEVPDEDVDERVETLRQRFATNTEVDRAAAKDDLVTIDLAGTRDGEALEDATASGVTYKVGSEGMLEGLDEAVTGLKAGESAEFHSTLVGGPLRGQDADIKVTVTKVCEQELPAVDDDFAQLVSQFDTVDEMRADLRTALENMARLDQAADARDKVLEEVISKIDIELPTNLVDSELEARRQQVNQQLTQAGMTVEEYLEDSEEEADNADDFWLRSRSVPWTPLKPKLSSTRWPMTTRSALSRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR2</accession>
    <name>W4TKR2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69535">
        <property type="protein sequence ID" value="GAE69535"/>
        <property type="gene ID" value="JCM18909_2761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="PTHR42695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18356" checksum="9F86EF77D594475B" modified="2014-03-19" version="1">MLAPTRQLISRTVRAGTPFLGICLGHQLATVALGGQVCTSDHFCLGAAEMHLTPEGKKDPLLSVYDGHRGIHFNNDVAVVLPEDAVLLARDPTGQIEAVRFAERAWGVQFHPECTPEIFDAWTIGHGEKEWQQRLPWSEAITAAETVRRDVDTVNAEKTFARDSGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR4</accession>
    <name>W4TKR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68749">
        <property type="protein sequence ID" value="GAE68749"/>
        <property type="gene ID" value="JCM18909_1905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24619" checksum="A905F40A5ED0842B" modified="2014-03-19" version="1">MWSFLAPLMVDGSPLRVTVGCSQLGAARTVLDYRAWHHDVEVARARGTICPFDFATGRPRRLTDGERGAFESMKVESQQWKPIKVVDVSEAGDFVEVPIRWSDVDRQGHVNNVSLAGYLQEARILATTSWSPGMKRAGNHLWVVVRQDIRYRRQVLPTQRSCRVHTALTRLGTSSMTLAGSIATEEGSALDAATVLVCVDPKTGASVPIDDQTRQALSAYLVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY6</accession>
    <name>W4TKY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69197">
        <property type="protein sequence ID" value="GAE69197"/>
        <property type="gene ID" value="JCM18909_2390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18354" checksum="0E12B1DF2D985DDA" modified="2014-03-19" version="1">MLRTDASSGVAPIFVDPESRNSILIIKGANAQLSPADVEGARQDIATCKLIMLQLEIPLETVYATIELGDVLGIPVLLNPAPVAPELDLERIRGIEFFMPNESELELITGMPVDTLDDIGKATDVLLGAGITNIIVTLGSRGAMWAHAEGRKIIKAPVFTPWTRQVLAMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL32</accession>
    <name>W4TL32_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2249 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68874">
        <property type="protein sequence ID" value="GAE68874"/>
        <property type="gene ID" value="JCM18909_2044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018720">
        <property type="entry name" value="DUF2249"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10006">
        <property type="entry name" value="DUF2249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2249" evidence="2">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10365" checksum="EAF57712388F4954" modified="2014-03-19" version="1">MTDHQEIPLTETHHCSCGESDTELPELDVRTIPHAIRHGAVIGAFAQLQPGASMVLIAPHNPLPLLSQLEQIGSVGVEYLVEGPDEWHLKLTKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL40</accession>
    <name>W4TL40_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69158">
        <property type="protein sequence ID" value="GAE69158"/>
        <property type="gene ID" value="JCM18909_2347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6335" checksum="4E739D9B6E7F1270" modified="2014-03-19" version="1">MILLMVMAFGIFMGKAVLLAPVAELNLPEHVNGSAMAVGSFFWRMRRSFGLTHLPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL77</accession>
    <name>W4TL77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-succinylbenzoic acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69491">
        <property type="protein sequence ID" value="GAE69491"/>
        <property type="gene ID" value="JCM18909_2711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7671" checksum="AA67C107155CC8AB" modified="2014-03-19" version="1">MLALPPHHIAGLQVVARAVGDGREVVVVEGRVDAPAVAAAVDEAVNRHNDGRVAISVVLPSCRGSSTTRLGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD3</accession>
    <name>W4TLD3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2444</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69248">
        <property type="protein sequence ID" value="GAE69248"/>
        <property type="gene ID" value="JCM18909_2444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="10">
        <location>
            <begin position="156"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="353" mass="39290" checksum="23345F6F7DC3386E" modified="2014-03-19" version="1">MLSSKDAIADVVEEIKGVDFYRPGHELIFNSITDLYGRGDPADTVTTADELDRRGELERAGGRLYLAELLTNVTVTANAAYYAKIVAEKAVLRRLVEASIRIAQMGYQGQGEVADIVDAAQQTLYDVSTRKTSEEYHPLSELFESTFDELEAIEARGDAMAGIPTGFTDLDELTNGFMPGQMIIVAARPAMGKSTLALDFARAAAIKNHLAAAIFSLEMGRNEIVMRLLSAEAGIELSRMRAGRLSEEDWQRMVDKTTQISSAPLFIDDSPNLTMMEIRAKARRMKQKKFDLKLVIIDYMQLMTSGKKRWSRVSWKSRSFLARSNCWLRSSRSLSWPFPSSTVAPNSAPTRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE4</accession>
    <name>W4TLE4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Osmosensitive K+ channel histidine kinase KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69342">
        <property type="protein sequence ID" value="GAE69342"/>
        <property type="gene ID" value="JCM18909_2548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0407">Ion channel</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10444" checksum="4F9B53DC3C3204F6" modified="2014-03-19" version="1">MSVVVDRAARKTRVARRTAAESGLLQSVAGLVLRGEDAVESLLSRATEAFGLSGARLMTDGKVVANWGTTSDQVTEHRIDDHTVVEFHGPEPDARSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ3</accession>
    <name>W4TLJ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69308">
        <property type="protein sequence ID" value="GAE69308"/>
        <property type="gene ID" value="JCM18909_2509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9602" checksum="AA255B416ACD3A83" modified="2014-03-19" version="1">MTDAMMNKRSKELGVSFDEAIESFLDQERPYMELKRRGEPEEVAAVIAFLCSDKASFVNGSNYRVDSGSVATFLRFGIHTCGAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN0</accession>
    <name>W4TLN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69338">
        <property type="protein sequence ID" value="GAE69338"/>
        <property type="gene ID" value="JCM18909_2542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16_C" evidence="1">
        <location>
            <begin position="77"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="344" mass="36115" checksum="55EE03DAFAFF3636" modified="2014-03-19" version="1">MPVTRFDAAAELFVELLNTTSLVEEDIARQIDAARASLAQTSQRGSSLAEMAAARALWPVGSRPSLPTIGTLSSVEKLNAAAAREFWAAHWTISDAVLVVAGEGVEDLDLSIFKEWTASGSPSQVAPLQPRLDGPRVILVDRPDAVQADVRIQQATVGRSHPGWAALKVACGALGGTFGSRLNQVLREDKGWSYGVGMSSRPLPDGGLATVAGSFRTEVGADAVAEALRILTSSDDLRADEVDAARDHSVGIAPLQYDTAGAVAHQVAALVGAGLAPNWVDDHLAAVASARTSAGEWSVNRAWRKLLIPDNWRIGICGQAERLAPALAERGLEAVVVSPAEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLQ5</accession>
    <name>W4TLQ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69432">
        <property type="protein sequence ID" value="GAE69432"/>
        <property type="gene ID" value="JCM18909_2644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6384" checksum="032DD237165872E3" modified="2014-03-19" version="1">MVADTWAGLPIRTGCIDAELCIFAPRNRDEFARIMNPDGILVVVTPLPDTCNSCGHAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT5</accession>
    <name>W4TLT5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2691</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69472">
        <property type="protein sequence ID" value="GAE69472"/>
        <property type="gene ID" value="JCM18909_2691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="133" mass="13645" checksum="34F001B1B7577CC0" modified="2014-03-19" version="1">MSLAKFTARSLLSAIFITGGLGEIKKADQLSEAVDGLLSKLPKSSCSQIPDVDSTLLVKVNGATMLAAGSLLALGIKPRLAATVLAAQLVPVTAAGHAFWEKEGAEKQGDQIQFCKNLGLIGGLLTVALDGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV9</accession>
    <name>W4TLV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69179">
        <property type="protein sequence ID" value="GAE69179"/>
        <property type="gene ID" value="JCM18909_2370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9405" checksum="D5F6512E3C4B61C0" modified="2014-03-19" version="1">MLDLGKLGADVQLLDPHRLIVRGPTRWRGRELICAGLASCRLSAIGRSGRFGRDDLRDVYMINRGYEDLPTRLGALGAKITVFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM19</accession>
    <name>W4TM19_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enzyme of poly-gamma-glutamate biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69239">
        <property type="protein sequence ID" value="GAE69239"/>
        <property type="gene ID" value="JCM18909_2433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="133" mass="13859" checksum="C4E14307BB9D244C" modified="2014-03-19" version="1">MPAEIAKGIAAVGFDACSTASNHSFDRGLPGVKATLDALDAAHVKHSGTARTKEEADTPVIVSHGLKLGLVSGAYGLNGSTPPRALHGRGVTSRQTTSLRGQKRQRRPAQTSLSSRLTLASNITMSRPGNRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM84</accession>
    <name>W4TM84_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69642">
        <property type="protein sequence ID" value="GAE69642"/>
        <property type="gene ID" value="JCM18909_2885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M13" evidence="2">
        <location>
            <begin position="11"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13826" checksum="CC7307820EE5910F" modified="2014-03-19" version="1">MPLQLQPDGPHVNGSLTIGENIGDLGGAGIAFKALQISFAGAEPEPIDGLPWQQRFFLSYARIWREKQRDESLRTQIATDPHSPTEFRSNQIVRNIDAFYDAFDVTENDPMWLAPEKRVTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB2</accession>
    <name>W4TMB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69329">
        <property type="protein sequence ID" value="GAE69329"/>
        <property type="gene ID" value="JCM18909_2533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="20262" checksum="9C10FD84CBB0A7AB" modified="2014-03-19" version="1">MSTLLVPTAVLVAFMVWLHRLTGSWTAWSQAQTNGWRRGFTTPAETLRHTLPATHADTWRSLYGAGASGVAIVFRLELVSVALGVLVFVYCLIRRRWASASWVGIQVVAFFSIGYWYMSVNRATLLWFPLFVALAEVTRGPSKPPGLVLLWRGIMGIVIAIDLAVMVWWGWRFYTGRWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG4</accession>
    <name>W4TMG4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome bc1 complex cytochrome b subunit</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cytochrome bc1 reductase complex subunit QcrB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">JCM18909_3472</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70175">
        <property type="protein sequence ID" value="GAE70175"/>
        <property type="gene ID" value="JCM18909_3472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:ubiquinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="17">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="18">
        <location>
            <begin position="230"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GAE70175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="532" mass="59690" checksum="EC1201F494E101D5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI6</accession>
    <name>W4TMI6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Imidazole glycerol phosphate synthase cyclase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69906">
        <property type="protein sequence ID" value="GAE69906"/>
        <property type="gene ID" value="JCM18909_3172"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17449" checksum="1A24E0D850163AF0" modified="2014-03-19" version="1">MAIRVIPCLDVKDGRVVKGVNFVGLRGAGDPVELAAEYGRLGADEVTFLDISASTEGRATTREMVTRCAETVFVPLTVGGGVRGVDDVDALLRSGADKVGVNTAAIAHPGMIDEVADRFGNQVIVLSVDARREPDRPSGSGVTTHAAPVRQGWTPLSGLPSRGAWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM5</accession>
    <name>W4TMM5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70240">
        <property type="protein sequence ID" value="GAE70240"/>
        <property type="gene ID" value="JCM18909_3538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="15806" checksum="BE496FC1C43FA92B" modified="2014-03-19" version="1">MIGDEEDAHAHENRRGQWPQGICHWAGVLTWGGQTDARETRSLVRRFVDAGGNLVDTAPAYGAGSPSNSSESSPIPISVEMTLSSRPRRDSLLKVIRESSIRHAVHCCVTSKGPCAVSTPITSIFGKFMPGEMPPSKKPVRHSTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN8</accession>
    <name>W4TMN8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I restriction-modification system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69688">
        <property type="protein sequence ID" value="GAE69688"/>
        <property type="gene ID" value="JCM18909_2937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004546">
        <property type="entry name" value="Restrct_endonuc_T1M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00497">
        <property type="entry name" value="hsdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N6_Mtase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="354" mass="39153" checksum="4E658F4A45633730" modified="2014-03-19" version="1">MPLGSFGDNAIDLFGDTYEYLMQMYASQAGKSGGEYFTPQEVSEVLARIAVGDKKRIGKVYDPAVGSGSLLLKFAKLLGPENVKGFYGQEINLITYNLARINMFLHGINYEQFDIVLGDTLTNPMHRDKEPFEAIVSNPPYSTKWEGSDNPLLINDDRYAPAGVLAPKSKADLAFTMHILSSLATNGTAAVVEFPSVLYRGGAERKIRKYLIDNNYVDTVIQLPPDLFFGTTIATCVIVLKKSKKDNSVLFVDASAEFSRVGNKNKLLSANQDRIVELVSARSEEPHVCTLVHNEDIAGNDYNLAVSSYVEPEDTHEETDIVELNSEIARIVERQSRIRAQLDEIIATLEDSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMP4</accession>
    <name>W4TMP4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69693">
        <property type="protein sequence ID" value="GAE69693"/>
        <property type="gene ID" value="JCM18909_2942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6310" checksum="B422EC64325FA3F7" modified="2014-03-19" version="1">MNADATRTSSSRWLKRARMSSHLGPQQVPQARRSDGERGFMTEEIAGLLKRCSSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT8</accession>
    <name>W4TMT8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation elongation factor LepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69733">
        <property type="protein sequence ID" value="GAE69733"/>
        <property type="gene ID" value="JCM18909_2982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10054" checksum="ACD741373F3959BF" modified="2014-03-19" version="1">MLVDAAQGIEAQTLANLYLALEANLEIIPVLNKIDLPGAEPDRHAAEIAGIIGCDEPEVLRVSAKTGEGVSDLLDTIVAKVPAPEGVADAPARALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU4</accession>
    <name>W4TMU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70300">
        <property type="protein sequence ID" value="GAE70300"/>
        <property type="gene ID" value="JCM18909_3608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40876" checksum="E33863D746FFA772" modified="2014-03-19" version="1">MIKGLLSTVSEPDAATLAKLTATVEKNNTANDPARSSAVPNQIGTTSSKIKHVIYIVRENRTFDQELGSNGRGNADPSLNLFGEESAPNTRALARQFTTFDNFYADAEVSANGWNWVSQANSNPWSEEMWPSNYSGRGAPYPAENNDPESRAKKHDSYFWEHLSKNNISFRNYGFYTTLDKKGKAHGVDKKILDPNTDHDFIGWTLDCPDSARSFAPMAKKTAGRNLVLTSGSPTSINSSLREACRRSSWFVSATTTPRPPKSGSRLPSLRRRQRSAIGQLVETVSHSPSGRTPRSSSLRTMPRTVPTTSTRTAPSARSSAIYPHWWGRFHLLLDSINAAHNGGHSRYRIADPIRRLFYPDVRRLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMV4</accession>
    <name>W4TMV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70310">
        <property type="protein sequence ID" value="GAE70310"/>
        <property type="gene ID" value="JCM18909_3622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="195" mass="21228" checksum="EA2A5E72F854963E" modified="2014-03-19" version="1">MTCLDVRNVQCRIGDRVIVDDVSFTAEAGQLTAIVGVNGVGKSTLLRSIAGVRKVNAGDVLLDGKSVNQYTPMQRARLMAFVGQEESPSPDLLLGEMVALGRTPHRKPWQVGQRSERAIIRDALALVGLDHLIDRRCDHLSGGERRRAVIARGLAQGADLILLDEPTNHLDVRHQLQLLETLRASGRTVVATITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY5</accession>
    <name>W4TMY5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70335">
        <property type="protein sequence ID" value="GAE70335"/>
        <property type="gene ID" value="JCM18909_3649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9073" checksum="15D1C1549B9AAB4A" modified="2014-03-19" version="1">MSRRRNEENTLDVRARLGHNVDQRNSDILGATTESARVGRSAGVFIAAMAITGLVWGLTLAIWATSLALTAPGRACRYKGGLAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN19</accession>
    <name>W4TN19_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69599">
        <property type="protein sequence ID" value="GAE69599"/>
        <property type="gene ID" value="JCM18909_2836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6124" checksum="A27B3AAF462A5A47" modified="2014-03-19" version="1">MHVHMLGGGLVDLLEEFLRLFCSVVSVDRGDHRSVVNIQCGEQAHCLAVWSIASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB1</accession>
    <name>W4TNB1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenylalanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70226">
        <property type="protein sequence ID" value="GAE70226"/>
        <property type="gene ID" value="JCM18909_3524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phe_tRNA-synt_N" evidence="5">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9174" checksum="0128392373C69A6C" modified="2014-03-19" version="1">MSGPNTNYDPVQVSALDADQVEARVAEALEAIARASTTAELKQVRITHTGDRSALALANREIGALPPAARKDAGKRIGQARGRVNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND5</accession>
    <name>W4TND5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloride channel related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70465">
        <property type="protein sequence ID" value="GAE70465"/>
        <property type="gene ID" value="JCM18909_3792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="8750" checksum="61A2B056C9C2BE82" modified="2014-03-19" version="1">MAGIDAPSQIAMMVIVGAGCVLSMTQRAPLFAAAFALELTRAGALGIPVVVAAVVLGWTGFVLVSRRGLGLHGRIGRAPGHTSDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW8</accession>
    <name>W4TNW8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ketol-acid reductoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69899">
        <property type="protein sequence ID" value="GAE69899"/>
        <property type="gene ID" value="JCM18909_3165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI C-terminal knotted" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7529" checksum="5C1764E1C700B42E" modified="2014-03-19" version="1">MKAVLDDIQTGTFAKRFIADQDAGAPQLRKFREDEAKHPIEAAGKELRKMYSWLAAADGDYTEGSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ1</accession>
    <name>W4TNZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III delta prime subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000073">
        <property type="protein sequence ID" value="GAE70705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70705">
        <property type="protein sequence ID" value="GAE70705"/>
        <property type="gene ID" value="JCM18909_4088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8307" checksum="1716094D3DE7CC82" modified="2014-03-19" version="1">MRDATPLVSSLRLRSLGDCLQAAEDLVNQASEEAAAATAEVNAAERAELEKAWGLAPLVLDRAMLKLLCGTLKSSNPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ8</accession>
    <name>W4TNZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70138">
        <property type="protein sequence ID" value="GAE70138"/>
        <property type="gene ID" value="JCM18909_3434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="389" mass="43011" checksum="6793BF42FEEB769A" modified="2014-03-19" version="1">MANGVLHNPRNDRRTTAGVFHVAEGGLAIPDDKKAVPIDVFARLLDLAFQAPPEHTLLPYTSTQPVDRQAHTWVSLLLRPLVVPEVPGFVSERRMEIRFFAPGGLVSNLDFVEGIFGNSGDPLLPVNDSALAPSGWTGHSGCIILAPHLNLIRKVDLGLPHVDQATDRQRRDGMCWSDESELYNEGKPFKLCARDESGVILTIVADNYFGYCKKEVKTQISYSANLFGLAEEEHSGGARAYISHNEGQEYATPVCDQTVSDVVMANPDHFEMLSDGQARVLDIDDVVMVPGGAKFSLRDDTVSWDNGDHSIRMRADTEYISPAGYRIHMVHNDADDQWYLEAPTAIRRPCISAARYPVVGSRRSPRPYRTPSCGAMLLSGFRGRHGCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP81</accession>
    <name>W4TP81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70004">
        <property type="protein sequence ID" value="GAE70004"/>
        <property type="gene ID" value="JCM18909_3282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850850" evidence="2">
        <location>
            <begin position="35"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="310" mass="33589" checksum="D997AD84A9D5FA7D" modified="2014-03-19" version="1">MSASPRRSIRALAIALVALLSLGACSHDDGDPNASPSDIHSTMKSTSVANDHVAGATMTSTSFHKPSDISIKVPTITTARNLSQAIEVVRERTLRGAAWDSATKVTMTGHFISSTTDLLGVELQAEVTRGKTTSQSTTTLWYDATMKQTLSASALISWPGWPKFSQEVVNSAHDDGLNSKKAEAALQQPQAPYGTGPALSFDSKGDLLVKFPAELSIAFNVLFSSIPRPSLRCSVGLARRPSAPRYTRRRSPVPRQQMRHGLPNSRRARNQQILRTSGPFRATRSPKRAAHRPTPQRQLVSIASSKTVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPA0</accession>
    <name>W4TPA0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70024">
        <property type="protein sequence ID" value="GAE70024"/>
        <property type="gene ID" value="JCM18909_3304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6686" checksum="C866162D45412CF8" modified="2014-03-19" version="1">MAKKRPRSCAQSSSYGRQLEPVTPTSPVKKPTQYPGSSRPQKKFDPIVRRHVEFKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPA7</accession>
    <name>W4TPA7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDE_Tnp_ISL3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000052">
        <property type="protein sequence ID" value="GAE70551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70551">
        <property type="protein sequence ID" value="GAE70551"/>
        <property type="gene ID" value="JCM18909_3892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9401" checksum="0D827799CA811B6A" modified="2014-03-19" version="1">MDPFRDYKHAIDDHLDNATAVLSPFHVVKLAAQALDEARSRVQQAPQATAAGLATRSTAFRRSCEPGPRTCPTSKKTPSCHRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPI0</accession>
    <name>W4TPI0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70119">
        <property type="protein sequence ID" value="GAE70119"/>
        <property type="gene ID" value="JCM18909_3410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1d" evidence="2">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16561" checksum="0E9D79C787654380" modified="2014-03-19" version="1">MADGLAVEDNGALCVFVEGQDAPMIVRKRDGGFGYDATDLAAIRRRVGKLKADRIIYVTDVRQSHHFEVLFQVARMAGFLPDDVEAEHVGYGMVFGLMAVLSRLVRVAQCRCRICSTRPRRTRLRISPWLPLNTPTCPTACRRTMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPI9</accession>
    <name>W4TPI9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70417">
        <property type="protein sequence ID" value="GAE70417"/>
        <property type="gene ID" value="JCM18909_3735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="9616" checksum="E01CA171C9BF7EB2" modified="2014-03-19" version="1">MVRIGVVTFPGTLDDQDAARAVRLAGAEPVSLWYASTDLAGVDAVILPGGFSYGDYLRAGALAAASPVMSSIRSGCRWGPASARYLQRISGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPL6</accession>
    <name>W4TPL6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ribazole-5'-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70159">
        <property type="protein sequence ID" value="GAE70159"/>
        <property type="gene ID" value="JCM18909_3455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="5889" checksum="A81BCAF7AB923E1A" modified="2014-03-19" version="1">MGLFRPYEQGTSKKTGPAEETVEAEPGSSTESSSSSATAAPKRAPKTSVTGKKTTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM9</accession>
    <name>W4TPM9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70368">
        <property type="protein sequence ID" value="GAE70368"/>
        <property type="gene ID" value="JCM18909_3684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7597" checksum="D860664475BBC10A" modified="2014-03-19" version="1">MTINRGEVVAFLGPNGAGKSTTIDMLLGMTSPIVGRSLFWVPIREQPHVLVASAPSFKPADCYPTSPSQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ47</accession>
    <name>W4TQ47_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000061">
        <property type="protein sequence ID" value="GAE70662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70662">
        <property type="protein sequence ID" value="GAE70662"/>
        <property type="gene ID" value="JCM18909_4033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5548" checksum="3FA33B6DA5C9292F" modified="2014-03-19" version="1">MWYDGSGEIVDPIDLSGSQEFSDEAPSNSGWAAWVATSIAPIPWVSHAANRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQS3</accession>
    <name>W4TQS3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70584">
        <property type="protein sequence ID" value="GAE70584"/>
        <property type="gene ID" value="JCM18909_3934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18786" checksum="F17E6330710B89BC" modified="2014-03-19" version="1">MIQESWEFSLSWHRSEITEIMAGHLRSALLIPIAAGVEAAIIWALGGWIICGNWPGWSELTIVGVVTLSIIMVIMVATEARRWRAAAWRSWQITPDWRGGAYVSPPTRRHGHMLMCVHAAPRNQATDHRFSPTSANGLTSKVSPWNSNPLGMLRSGFMSGLVSLRRLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR49</accession>
    <name>W4TR49_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobN component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000095">
        <property type="protein sequence ID" value="GAE70724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70724">
        <property type="protein sequence ID" value="GAE70724"/>
        <property type="gene ID" value="JCM18909_4113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11351" checksum="8076A525BE7809A7" modified="2014-03-19" version="1">MPISIVAAGGESLEALRTLLSEAAPKLIISMQGFRIGGGPMGGDVDSSTAMLKSINAPIMHPLILSRYTEKQWNESRHGLGQSESHGHAHVTRNGRLSGRDTDSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDN0</accession>
    <name>W4TDN0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ORF">JCM18909_90</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67055">
        <property type="protein sequence ID" value="GAE67055"/>
        <property type="gene ID" value="JCM18909_90"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="54"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="127"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="216" mass="23073" checksum="7EECE262BAC8C10B" modified="2014-03-19" version="1">MTVTNNEIAREFAERLLAIEAVSLSPDAPFTWVSGLHSPIYCDNRVTLSDPQTRDLIADGLASLVRTNVHQVDVVAGTATAGIAHAALAADRLGAPMAYVRSAPKDHGRGNQIEGRIPAHSKVIMVEDLISTGGSVLKAAQAVEREGSTVVGVLALFSYELEKGHRAFEKAEVPLYTLSNYPTLIEVAAESGRITSEQQATLATWSSDPQAWSDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE04</accession>
    <name>W4TE04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_31</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67001">
        <property type="protein sequence ID" value="GAE67001"/>
        <property type="gene ID" value="JCM18909_31"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="16938" checksum="8891E2A9F63B3575" modified="2014-03-19" version="1">MLTPGADGVPGANSKAAEIVENTPGAILASQFDNPANPAIHHDRTGEEIWNDTEGEVDAIVAGIGTGGTISGAGKYLKEKDPEIKIFGAEPAESPVITKGDKAPHKIQAGARALSRITSTSPSLTRSCWFPVMRPSPSPVALPQKRALSRVSPVAGPCKLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEA4</accession>
    <name>W4TEA4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67116">
        <property type="protein sequence ID" value="GAE67116"/>
        <property type="gene ID" value="JCM18909_155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6356" checksum="7F8BAC0093054472" modified="2014-03-19" version="1">MCTVSPLPRGVSELLADEVEMLSMVTVAAYRQPTTRNPGTVFAPSHPSFDTYGNIPTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEB2</accession>
    <name>W4TEB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67305">
        <property type="protein sequence ID" value="GAE67305"/>
        <property type="gene ID" value="JCM18909_351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6085" checksum="7981E921D2378563" modified="2014-03-19" version="1">MSFKPDFTQRVELEDARKLYRILDALEDLDDVQNVFSNVDIPAEVAAALDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEB7</accession>
    <name>W4TEB7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secD</name>
        <name evidence="11" type="ORF">JCM18909_357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67310">
        <property type="protein sequence ID" value="GAE67310"/>
        <property type="gene ID" value="JCM18909_357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="552" mass="58332" checksum="A6EBFB9B7C0F443C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEE2</accession>
    <name>W4TEE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67335">
        <property type="protein sequence ID" value="GAE67335"/>
        <property type="gene ID" value="JCM18909_382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="6023" checksum="76D081A17DF1F052" modified="2014-03-19" version="1">MAIDNLKAQILALGESVSLDDETYDQSARVQARIDRLDEQIRTYDRNEQLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEM3</accession>
    <name>W4TEM3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <shortName evidence="2">Tpx</shortName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peroxiredoxin tpx</fullName>
            <shortName evidence="2">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpx</name>
        <name evidence="4" type="ORF">JCM18909_463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67405">
        <property type="protein sequence ID" value="GAE67405"/>
        <property type="gene ID" value="JCM18909_463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17705" checksum="BB2CD35B283CF0F2" modified="2014-03-19" version="1">MATTAFMGKPLNTVGDLPQVGSLLPSFTLVKSDLSELRSDELKGKKLVLNIFPSVDTGVCATSVRTFNEKAAGLDDTTVLCVSRDLPFAQARFCGAEGIKNVVVASAFRSHFGKDLGVTLADGPMQHLLARAIIVVDAEGKVTYTQLVDEITTEPDYDAALEAASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFA7</accession>
    <name>W4TFA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67441">
        <property type="protein sequence ID" value="GAE67441"/>
        <property type="gene ID" value="JCM18909_502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="41"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="21925" checksum="FE3DFD49BD71BF08" modified="2014-03-19" version="1">MPDLSDGFVQSTDSDPSLPNIRVWAGEVAEKMKGCELGESTLANNHIDTIAEVNAVVATALEAQYSWAGRGGNARAEILRTVTHAFATRRGDLVAVAGAETGKILAEGDVEVSEAIDFAAWYADRAEELEAVDGAVCAATGDRRHPAVELRPVYYRWIHLRRSGRRIVGTTQARPTGPPLCCRHRRMSVGGWDPAGCPAIRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFB9</accession>
    <name>W4TFB9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2183 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67128">
        <property type="protein sequence ID" value="GAE67128"/>
        <property type="gene ID" value="JCM18909_168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="DUF2183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2183" evidence="1">
        <location>
            <begin position="197"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="337" mass="37676" checksum="C25A186225DBDDEE" modified="2014-03-19" version="1">MPCVIGYRSYGSATHLRVLGRVVLTSPPGRNPEQKRQPDRSPLTRRNLLSIELLSQRGWRNFLGLPAPGAEVVVDVNGEKITVRADRAGYVDVRVKKITVCNQAGMKSPCQPAVIPRRQRFSWCPGTLDSESSLTLTILSSLLPYPGLSSRLGTPSCSPSRPANPFPAWHGCIRNSWNDIPTPRWSMCRLARGIPTHFLVRFLARHGYPQGPLLLTDWGPTNTGWFRSGVDHKRTALRELARDFPDIEWVLVGDDGQHDIRIYSEFDELQPGHTRAIAIRELSTTQQVLAHGTTTVLEDRHRVQWTPESAPLVRAPDGDQLAPLLDKVLNHEDPPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFF4</accession>
    <name>W4TFF4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mobile element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67163">
        <property type="protein sequence ID" value="GAE67163"/>
        <property type="gene ID" value="JCM18909_205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10514" checksum="0F8AC71673D6872D" modified="2014-03-19" version="1">MPAAKPVEFRRRALDLVAAGEPVAKVARDLGISEPGLRRWMEQADVDAGRREGLTSAEKRELVELRRRNRVLEMEILKRASAYFTRENVLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFI9</accession>
    <name>W4TFI9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67735">
        <property type="protein sequence ID" value="GAE67735"/>
        <property type="gene ID" value="JCM18909_815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="357" mass="37255" checksum="4047DF5AB967AA3A" modified="2014-03-19" version="1">MTSMVIIGAGPGGYEAASVAAAGGVDVTVVEETGIGGAAVLTDCVPSKTLIATAEVTSTLRRAAELGLRHTETFEVDLDAVNSRVRQLAQAQSDDISRGLERKGVRLISGRARLATGAPGHLHRVVINDDETIDADIVLLATGTTPRELPAARCDGERILTWKQVYSMREVPEHLIVVGSGVTGAEFASAYDSLGCPVTLVSSRDQVLPGEDPDAAQVLQQVFESRGMEILSRSRAVSAIRDGDGVVVGLEDGRTVRGSHVLMAVGSTPNSADLGLEEVGVAVGPRGHITVDKVSRTNVPGIYAAGDCTGVFALASVAAMQGRIAVWHALGQALQPLDLSLVCSNVFLPLPRSPQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFJ4</accession>
    <name>W4TFJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67740">
        <property type="protein sequence ID" value="GAE67740"/>
        <property type="gene ID" value="JCM18909_821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5849" checksum="0AD0F25160CC8E55" modified="2014-03-19" version="1">MVRDGPRGPQVLLVQRADDGQWTPVCGIIEPGEGPDEAILREIHEETGIVAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFL6</accession>
    <name>W4TFL6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67322">
        <property type="protein sequence ID" value="GAE67322"/>
        <property type="gene ID" value="JCM18909_369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="5339" checksum="5B4B07E5035A4227" modified="2014-03-19" version="1">MWFPGVKHADHRDADTVKDIRSGDQVEADAASWNPPIEDLHPGVIGTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFM8</accession>
    <name>W4TFM8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67243">
        <property type="protein sequence ID" value="GAE67243"/>
        <property type="gene ID" value="JCM18909_288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10784" checksum="CE49CA85D74DFEB8" modified="2014-03-19" version="1">MLFRSSSTPNGRPFFDVDEQVIISTALAPEFTAEGIARLAPMDRTHTAELEADWMPGWGDTIIAVVSLSQGRCLVVGRQGGPGFLASELNRLQHMAALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFN3</accession>
    <name>W4TFN3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67586">
        <property type="protein sequence ID" value="GAE67586"/>
        <property type="gene ID" value="JCM18909_658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18235" checksum="7EB9BF3BABCAB0C1" modified="2014-03-19" version="1">MADPRPSRLPVGHGRATDRGIDHRWIRRRLIGVVAPYRAILHDAMGSTEIDVPALIDTIPDDKVFPSAEDELSALDTVASLGNAHLSQLCDGVRKKTVFGCNCWSRATHHACPHTVGRVFCADIDRTGLTSCTSTLTRRVRCSYLWNRTRRPSPSWRPPWPGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG02</accession>
    <name>W4TG02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67716">
        <property type="protein sequence ID" value="GAE67716"/>
        <property type="gene ID" value="JCM18909_795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5231" checksum="5A6C729DF25841B8" modified="2014-03-19" version="1">MATPLVLGALCGVMCERAGVVNVAIEGEMLTAAFAAALVGSITKSIFLPPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG37</accession>
    <name>W4TG37_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67109">
        <property type="protein sequence ID" value="GAE67109"/>
        <property type="gene ID" value="JCM18909_148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="184"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="461" mass="50311" checksum="3B8CF1B27C99E909" modified="2014-03-19" version="1">MPGGVHETLIAAGIIAHPYVKDHEENCRWVEDRAWWYRGTVPIPVGDDPLVLTLTGVDTVADIWVNGHHVGHHASQYRPFQVTLPPIDANKAKVLIRFAPPLDGLAEPPATRAMVNAVSDFLNAAAPQNLDAEPGAGILTLDLAATRRRKGMFSWGWDFAPRIPSIGLTGPVELTRRSPIEVSHHVDTMAIGDGDSADVNVVVSTAHHNGPAPCTVDVTLTSPDGDRVSGHAQLKHGSATVDLQLDNPQLWWTHDLGKPSLYQVDIKICDKDANTIATDSGMAGIRTIEVDCSPDTDDPETDGPARHFTFILNGVPVFARGANLVPQSMLPGSVTPQQDHDLVRACRDANMTMVRVWGGGVYASDAFMTACDEYGILVWHDFMFACIDYPGDDEEFMSEVRTELTIKPAVSLIIRVWRCGLEAMRCRPCTRRSGTTLTRAHGDPRSSTRSCLRRFVATARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG81</accession>
    <name>W4TG81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydropteroate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67960">
        <property type="protein sequence ID" value="GAE67960"/>
        <property type="gene ID" value="JCM18909_1062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850730" evidence="1">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="207" mass="22529" checksum="57FA3DB138429381" modified="2014-03-19" version="1">MRRVLPVVKALVADGVAVSVDTMRASVAKAVVEAGATIVNDVSGGKAEPEILDVVADASVDYVLMHWRGQSATMQNLVDYDDVVADVISETSQQVDAAIAAGIDRRRIIVDPGIGFSKTSEHNWQLMNAVDAFQEGFADLRVLWGVSRKRFLGELLAQNGEDRPALERDASTMALSTYFALHHAWCVRTHEVRANRDAVETVARLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA4</accession>
    <name>W4TGA4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67562">
        <property type="protein sequence ID" value="GAE67562"/>
        <property type="gene ID" value="JCM18909_632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="6">
        <location>
            <begin position="461"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="604" mass="64544" checksum="1D2CFC4AA48E189F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ1</accession>
    <name>W4TGJ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68075">
        <property type="protein sequence ID" value="GAE68075"/>
        <property type="gene ID" value="JCM18909_1187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6847" checksum="9EB7F3980080CE18" modified="2014-03-19" version="1">MVIDLFEVGWSSRRTIEVMRLSIVIMPRIVHYECPIRVVRLGYSARLRGFCQFSCELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ6</accession>
    <name>W4TGJ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67538">
        <property type="protein sequence ID" value="GAE67538"/>
        <property type="gene ID" value="JCM18909_604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15142" checksum="C8162F3BA76F57F7" modified="2014-03-19" version="1">MFGRIDGGLGNAIGGGCIDQLPPPKCSENVATSSPPTMILSAFLMVTRRPVPSVVVTGNLSVAFATGMSDPSTQVQPCGRRIAAGTERFPWLDEDDSRTADCPWDLQPARHEEIKATGKPATSVRRAIAGSMWGTSNLPFISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK8</accession>
    <name>W4TGK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67553">
        <property type="protein sequence ID" value="GAE67553"/>
        <property type="gene ID" value="JCM18909_620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025445">
        <property type="entry name" value="DUF4191"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13829">
        <property type="entry name" value="DUF4191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="256" mass="28136" checksum="F28B4B65D4CC2A19" modified="2014-03-19" version="1">MPKSQAAKELAAKQKAQAKAEKERRKHSDNPKDWGTGKQLVETFKLTRQVDPQLLWWVIGSFVAGVVVFTVLGLILTDLWWAWLIVGIFAGAAAAMWGFQWRAKRSMYARFKGQTGSAEVALSLLDKKKWTSTPAIAFTRQQDVVHRAVGPGGIVLIGEGHGNGLRNLLATETKRHEQVAYGTPVTSIIMGDGKGQVPQENLDKHIKKLPKALSTSQVDEVVNRLKALDAMRPKVPLPKGPMPNSMKGARAAMRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM4</accession>
    <name>W4TGM4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67687">
        <property type="protein sequence ID" value="GAE67687"/>
        <property type="gene ID" value="JCM18909_765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="9936" checksum="D4B475C2C5F023DF" modified="2014-03-19" version="1">MGAEAADLTWTVTVSDATGTIPLSITQFNVQDEAGKYHWAQPVKGSPVPAKIGKGQKVTFTIHTVASAGEGMVRWAPDGKHVVALWDYIAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP7</accession>
    <name>W4TGP7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67598">
        <property type="protein sequence ID" value="GAE67598"/>
        <property type="gene ID" value="JCM18909_671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10945" checksum="62F1954F9C83AB86" modified="2014-03-19" version="1">MQDSTFLKELNADGMTVPGITYTVIATRFDNRVFPWTNTFINEPGVKNIVIQDVCPLDHSAHTNISYDPMTLQIVINALDPERAAPVICTIRPFRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU6</accession>
    <name>W4TGU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67648">
        <property type="protein sequence ID" value="GAE67648"/>
        <property type="gene ID" value="JCM18909_722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="102"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="162"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="266" mass="28752" checksum="0CDE0788A7803C52" modified="2014-03-19" version="1">MTSDSRPTTIEELAPLALTFDDVLLQPVESNVIPSQVKTTTRVSRNISIAIPLVSAAMDTVTETRMAVAMAREGGLGILHRNLSIEDQAAMVDQVKRSEAGMIDEPITISPNATLADAEELCHTYRISGVPVVDDKENLVGIITNRDMRFEDNPQRPIREVMTAAPLVTAPVGTSPSDALSLLAAHKIEKLPLVDADGKLRGLFTLKDFVKTDKYPNATKDPQGRLRVGAAIGFFGNSWDRAMALVEEGVDLIVVDTAHGHTQGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX0</accession>
    <name>W4TGX0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67673">
        <property type="protein sequence ID" value="GAE67673"/>
        <property type="gene ID" value="JCM18909_750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp_2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Ligase_CoA" evidence="6">
        <location>
            <begin position="118"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="252" mass="26455" checksum="9D59CB1C717C96E6" modified="2014-03-19" version="1">MPVDPIDGVDDAKAREILSEAGFPDSEQDAIVPAVLKLWETYRDEDATLVEVNPMIKTGDGRILAIDGKMTVDNNASFRQLDHAGLVDRATTDPLELRAGELGLNYVKLDGNVGVIGNGAGLVMSTLDCVAYAGEDFPGSPAPANFLDIGGGASAEIMANGLDLIMSDEQVRSVFVNVFGGITACDQVALGIKGALEKLGDKAVKPLVVRLDGNAVAEGRKILEEFNHPLVTMVSTMDEAASKAAELASKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH11</accession>
    <name>W4TH11_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="3" type="ORF">JCM18909_1178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68066">
        <property type="protein sequence ID" value="GAE68066"/>
        <property type="gene ID" value="JCM18909_1178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15575" checksum="24C4D934C9BE5F21" modified="2014-03-19" version="1">MKPPNPRVAKLADQIRVVVAETLERRVKDPRLGFVTITDVRLTGDSRDATLFWTAMGTDQQIASTAAALKSAKGLLRSTVGKRLGLRYAPTLTFVRDATPETAKSIEDALARAAASDAEIARRSEGAIPAGETDPYRHRDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH36</accession>
    <name>W4TH36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68096">
        <property type="protein sequence ID" value="GAE68096"/>
        <property type="gene ID" value="JCM18909_1210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13538" checksum="2EA5541FFDE88BA2" modified="2014-03-19" version="1">MLNIILRDVIEQPTTLTNHEHQTTTRMVITLMNLKMLSKLGNALGEDGNLNIGGTRVSRMCRVLFNDLLFFSAASISVGPFLSVARRPRRSYCRRLFQGRGRPDGNWERISTLPMRCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH63</accession>
    <name>W4TH63_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67867">
        <property type="protein sequence ID" value="GAE67867"/>
        <property type="gene ID" value="JCM18909_958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="138"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="209" mass="22518" checksum="F2D292983DE80455" modified="2014-03-19" version="1">MRAGFRLVLDAQPDMSVVGEANDGAEAVQLVDELAPDVVLMDIRMPVLNGLGATEKIMTGHPEAKILMLTTFDLDEYVHSALRAGASGFMLKDAGPTELLAAIRAVRDGDSVVAPSATRRLIERFIPRQGEGAATITDPKLVETLSDREREVLTCVGEGLTNAEIAERLYLAETTVKTHIGHILSKLGLRDRVSMVITAYDAGLVRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH95</accession>
    <name>W4TH95_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67509">
        <property type="protein sequence ID" value="GAE67509"/>
        <property type="gene ID" value="JCM18909_573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848751" evidence="2">
        <location>
            <begin position="26"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="228" mass="24392" checksum="991004A14C445F22" modified="2014-03-19" version="1">MIIVILVVAVVVAFALHRGTSSDHNAEPDLNSSSPTVSAWNEKSATPSAGSSAVTCPRGQHPGNQDSNDGRLHGGGVSVESIPNWRHENLTLPWVMGQSAQIDDIYPGWMSVSGVGGLPVAEGFSDPQTAATMTMDCFASSDYYAGYTGEKEIRSEALTIDGHPAWWKRSEVYVSLPNLPQVRGDVVDVVVVNTGQTDFLGMYFNSATIGDSTRQALVDHARESLKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD6</accession>
    <name>W4THD6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stomatin/prohibitin-family membrane protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1328</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68206">
        <property type="protein sequence ID" value="GAE68206"/>
        <property type="gene ID" value="JCM18909_1328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="292" mass="32989" checksum="385835B5B55C4BEA" modified="2014-03-19" version="1">MSDLEWTFTTIALVILVIGFLISSFKIIPEYERGVVFRLGKLRGLHGSGLVFIFPGLDKLHRVDQRTVTLTIPPQEIITRDNVPARVNAVVLFNVTDPMDAVMNVENYAIATSQIAQTTLRSVLGRADLDTLLAHRRNSTRTSVRSSRCRRTRGVLMCPSWRLRTWRSRRRCSGPWPVRRRRSGSGGRKSSTHAARCRRPASCGRRPTNSRRARPPCSCGICRRFLSWEPIRTRRSCSHCPWISSPPSFAKITGIDRWGSGLQDGRALPACVGACLPEVWSSRVCNRLIIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF2</accession>
    <name>W4THF2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67922">
        <property type="protein sequence ID" value="GAE67922"/>
        <property type="gene ID" value="JCM18909_1022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="18273" checksum="89934503AE826D66" modified="2014-03-19" version="1">MEWQDSMPTQQWPVQDSTPTQRWTTNSQSRPQQPSQGQYRDLGASQMPDDWFRDPEAERTRVMAAVPENPVFTPPPPPSTPAMAYPPLPSGDSPRHRKVLIGLVVGLLVLVVLGAVLLFLPAVSKGGRVVSLLWLRPRRPAHSPSSQPRRIRRLHRLTPPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF3</accession>
    <name>W4THF3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68221">
        <property type="protein sequence ID" value="GAE68221"/>
        <property type="gene ID" value="JCM18909_1343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="294" mass="31737" checksum="AA1829683B7E97C8" modified="2014-03-19" version="1">MFPKTLADRLTVDGHIYSVPVDIHRANVVWANSALLKKAGVTKTPTDVKGWIADIEKVKASGVATPLSIGGTWTQTELFESILAADMGADGYNKLFTPDGTWDSPEVKAAIEDYKKALTFTNTASDGDDWPAATDMVASGKAAYNVMGDWAVAEFDMKGKKYNADYTAFAVPGKEVVYDFLADSFTLPTGTKNPEATKDWLRFVGSADAQSTFNKIKGSILARTDVKPDGFSTYQQIAMKDFKEVPIVSSIAHGAAVSLGWSSEINTAMSKFYQDKNADNLASALVAAHDKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG0</accession>
    <name>W4THG0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67932">
        <property type="protein sequence ID" value="GAE67932"/>
        <property type="gene ID" value="JCM18909_1033"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20393" checksum="14C09B0255DE885B" modified="2014-03-19" version="1">MRASDIPGDFDHVLYTEEQVASRIREVAAQIDADYAGREILMVGVLNGAVMTMADLCRAMTSHMSMDWMAVSSYGAGTKSSGVVRILKDLTKDIDGRDILIVEDIIDTGLTLSYLVQNLRSRNPNSIEIMAMFRKPEAVTCPLDVKYVGFDIPNEFVVGYGLDYADKYRNLTDVATLAPHVYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH2</accession>
    <name>W4THH2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68241">
        <property type="protein sequence ID" value="GAE68241"/>
        <property type="gene ID" value="JCM18909_1364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="463" mass="50650" checksum="FC8B0D95EEDDA071" modified="2014-03-19" version="1">MGALRHLYDIVGIAPTSVVATSAGSIVACTLAQWTDPARQSAALRQLEAMWLEMTDQSDMFTPRAWFSRLLEIGPEWMSLLNREAAKTKSQRPWLSLPFHRGPEQTKVPDPAEPVAGRDDDRLTGQARALEIATRDDPITGGSWTPGVILQLLSALSRLSRDGGDISTIVRGAETSASTYRAGPILAKLLDRGFFKSELLATSGMSVRIATVALESGELRYMTESGVLVDRDNNPIGSSTFDVSRGVLASCSIPGVFRPVDLDGEHYVDGGLRENVPAEMAIGHLGVTNPYIITCSPQGAARESDFGSRNMLDLVMRSVSILTDETERDEVAYALNAGAVVIGPEISVHDSMTVDPGLLRINRDYGWMCSAEKHVTSSPDEHELVKDAVRTRVRGWELEQAWLKGEASRDDMDEMQHLKDHLRDIAARLPRDLAPDGVETWGRVLEGHGHPQAPEDVVIPWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL3</accession>
    <name>W4THL3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68002">
        <property type="protein sequence ID" value="GAE68002"/>
        <property type="gene ID" value="JCM18909_1107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17212" checksum="CBCA20816A379656" modified="2014-03-19" version="1">MASHRRQRLMSGSSASSVGLVTAIPYIFAVVGMLAVSSWSDHTGNRRVAIAVPLAIGAIALTVGQLVHHPIVNIVLLVIVAIGVYSPYGPYWAVPGAYLRIEVLAGGLGLINALGNLGGFVGPYLVGWLTNLTGSAATGYYALAGLLVVGAVLAWVVVKPKITPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP8</accession>
    <name>W4THP8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68460">
        <property type="protein sequence ID" value="GAE68460"/>
        <property type="gene ID" value="JCM18909_1599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6571" checksum="4ADF4F5E0C93B401" modified="2014-03-19" version="1">MTLRQKRGGDRYADIDKWLSRVDEREELLDLVAAYQNLKKERGLVEFGDRMVQAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ6</accession>
    <name>W4THQ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68047">
        <property type="protein sequence ID" value="GAE68047"/>
        <property type="gene ID" value="JCM18909_1155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40082">
        <property type="entry name" value="PTHR40082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="247" mass="26839" checksum="EA600E57589DABBF" modified="2014-03-19" version="1">MEPPRTPQQMDKAIRGLVEGRYEWVVFTSANAVRAVSEKLEQIGLDARAYSGLRIAAIFDSTINALAEWGVRPDFVPSGEQSTRALAAVFPAFDEALDPINRVFVPRADIATESLSADLSELGWEVEDVVGYRTVRAAPPPAETREAIKTGKFDAVVFTSSTTVRNLVGIAGKPHKHTVVAAVGMRTAETCREHGLTVDVIAPEPTALSLADALADFAAKRRDDMVAKGLPVVRPSQRKRRGRHPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ9</accession>
    <name>W4THQ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67714">
        <property type="protein sequence ID" value="GAE67714"/>
        <property type="gene ID" value="JCM18909_793"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="423" mass="44139" checksum="736E1227CC019E6F" modified="2014-03-19" version="1">MSTESPKPTASKEATSPTAATASQTEATSHRSFPWNDLWVTVAAFVLAFIVSAIVMVAADPAINKEWSYLFSRPDALSDSWAQISSAYAALFQGAFGSWQALTATTAQSASLICGGLAIGLGFKAGLFNIGGQGQAIAGATLAAWVGFNFHSLPLPVHLLFAVIAGFVGGAIWGGIAGILKARAGANEVIVTIMLNYIAGGLLAWLLTTKAFQMPGRTDPIAPIVDWNATFPRMAGSQLHLGFFLALLLAVGTWWLLDRTPLGFQIRAVGSNPNASATAGMNTNSIIAWTMIISGGLAGMAGVEVALGPISGATPTQLSIGLVGTIGFDAITVALLGRSKPLGIVLAGLFWGAMNQGGLRMQAMTQTSLDLVRVIQAVIVMFVAAPMLVKTILPFLKTRREKRTKKRDRGPVPADTTTKGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS9</accession>
    <name>W4THS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67973">
        <property type="protein sequence ID" value="GAE67973"/>
        <property type="gene ID" value="JCM18909_1075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpB_D2-small" evidence="2">
        <location>
            <begin position="110"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="234" mass="26246" checksum="8378B5F7EC557D4B" modified="2014-03-19" version="1">MRRKPFSVILFDEIEKAHPDIFNSLLQILDEGRLTDAQGRVVDFKNTVIVLTTNLGTRDISKAVNLGFSKVDDVESSYEKMKAKVTEELKGHFRPEFLNRLDEIIVFHQLTQPDILRIVDLMVGQLEDRLADKDMGIEVTPAAKELLSKRGFDPLLGARPLRRTIQRDIEDVLAEKILFGEVKPGQIVVVDAAPEGSEEPFVFTGTERSELPDEIPPELTSSAGENNKGQQLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV3</accession>
    <name>W4THV3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68003">
        <property type="protein sequence ID" value="GAE68003"/>
        <property type="gene ID" value="JCM18909_1108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23620" checksum="C364824B284BBC04" modified="2014-03-19" version="1">MAINSVNNLEMTDKADASKPPAKRWVYVIPVAVVMYMLAYLDRTNTAMILPYINSDTSSQIHLTKADEGIVSGIFFFGYMFLQIPAAILAERWSAKKTVAILMFLWGFAAMAVSFVQSNGQFYTARFVLGFFRRWRMALGAHPHRQLVPAQRACQGQFPVDVLPTPVIGAYFPDHWSTPRPFQLADGALRGRSPATDMGDRMALSRLRPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX9</accession>
    <name>W4THX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68127">
        <property type="protein sequence ID" value="GAE68127"/>
        <property type="gene ID" value="JCM18909_1244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4307" checksum="2F8CA668DA524605" modified="2014-03-19" version="1">MSTDPREVAAGTVIALIPIIIIFASMQKVFFRGVESGGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI26</accession>
    <name>W4TI26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67819">
        <property type="protein sequence ID" value="GAE67819"/>
        <property type="gene ID" value="JCM18909_905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="414" mass="45287" checksum="018FB7A40A093544" modified="2014-03-19" version="1">MPASQEFTTMHDVTPVIQPFRLTTAPDQPVGLAAGTLDGAVTLPLVECLTLEHGRYFVDHRLTQTTVGSGLRPVRREPLTSPWPGTRVIQHDPGSDLTVTVDLWHPTSATLHGRTTVHNDGTLPVHLTAVSVMCASLLSGAELDDLDILIAPSAWMAEQRWTHHRLSDLLVDVGTELHGESPRDRFVLSSESGWSSGRWEPVGFITDPASGRAVGWQIEHNGGWTVELARRSSTLDLCLFGPTDLQHHWMHQLNPGETFTTPTVTLVVSDNSWQGAAAELSTYRRALRGNNGTAAPIVFNDYMNTLMADPTAERLSTLIPAAARTGAEVYCIDAGWHSDDTDWWDDVGRWEPSPRRFPGGLRHTLDLIVAYGMTPGLWIEPLAVGLRSPLVNDLPPELSCAAQGFRSSNRIGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI31</accession>
    <name>W4TI31_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67824">
        <property type="protein sequence ID" value="GAE67824"/>
        <property type="gene ID" value="JCM18909_910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017821">
        <property type="entry name" value="Succinate_CoA_transferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03458">
        <property type="entry name" value="YgfH_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="4">
        <location>
            <begin position="334"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617821-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617821-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="504" mass="55077" checksum="7905255AEF7BDE8B" modified="2014-03-19" version="1">MSERIANAALRQKVMSADDAAALIHDGDQIGFGGFTGSGYPKELPGALAKRIQESHDRGEKFTVNVFTGASTAPELDGALASVDGIGWRMPYQSDPQMRSKINDGTSFYTDIHLSESGMMVRQGFFGKVDFAVIEATRITADGDVVLTSSVGNNAVYCDTAEKVIIEVNSWQSEDLEGMHDIYGGFALPPSRVPIPITHPGDRIGDKFLHIPQNKIVAIVETAGPDRNTPFKPIDDDSRKIAGFLLDFYDNEVKQGRIPKNLLPLQSGVGNIPNAVLDGLLHSDLEHLTSYTEVIQDGMIDLIDAGKLDVASATAFSLSPDYAHKMNENAAFYRDHIILRPQEISNHPEVIRRLGVLGANGMIEADIYGNVNSTHVMGSRMMNGIGGSGDFTRNAYISAFVSPSTAKGGAISAIVPMVSHVDHTEHDGMVIITEQGIADLRGLAPRQRAPKIIENCAHPDYRPMLLDYYERALRDCKFKHTPHLLGEAYSWHTRFLETGTMKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIA4</accession>
    <name>W4TIA4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68690">
        <property type="protein sequence ID" value="GAE68690"/>
        <property type="gene ID" value="JCM18909_1841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8369" checksum="37D4D7CE1E441A8E" modified="2014-03-19" version="1">MTMGAHQVANAVAATAAALAALAMNDDIDDQSVTRIAEALSNAVSRSAMRMQLRERADGWCWSRTATTPTLTRWPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL6</accession>
    <name>W4TIL6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68377">
        <property type="protein sequence ID" value="GAE68377"/>
        <property type="gene ID" value="JCM18909_1510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8516" checksum="A7057230583AB197" modified="2014-03-19" version="1">MLPLPGGRILGATPIGDTNLWREVMPTDPDNPYQPTTVAIEGVPETIRMAGNALVVDGHPWWGRASTTQLPPPSCLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIM4</accession>
    <name>W4TIM4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactam utilization protein LamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67979">
        <property type="protein sequence ID" value="GAE67979"/>
        <property type="gene ID" value="JCM18909_1082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14682" checksum="6706F3C193F71DBC" modified="2014-03-19" version="1">MGESFGSWKTGNDESLLGIVTSANVACGFHAGDAVVMGRTCKAAAEHGVCIGAHVSYRDLVGFGRNFIDVDPGRLRDEVIYQLSALRGVAAVHGAAVRYVKPHGALYNTIVHHQAQPRQSSRRSALSTPPRAPIWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN7</accession>
    <name>W4TIN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease of the drug/metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68646">
        <property type="protein sequence ID" value="GAE68646"/>
        <property type="gene ID" value="JCM18909_1796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="47"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="14832" checksum="CDF53273294654FF" modified="2014-03-19" version="1">MVFTPLLAAVIFRKKVSTAIWGAVALATVGMGVLALDPSTLGSGFGIGQLLTLASAVAYAGHIVATGRFANPSNVTSLGLYQTITVAIVCTIAALPGGLSAPTHMEDWLALAYLAIICGALTTFMQSWGQARGIDPCRRHHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX8</accession>
    <name>W4TIX8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68109">
        <property type="protein sequence ID" value="GAE68109"/>
        <property type="gene ID" value="JCM18909_1224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMMBL" evidence="1">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_J_C" evidence="2">
        <location>
            <begin position="135"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="232" mass="24714" checksum="B74B13D43740CFD3" modified="2014-03-19" version="1">MGEGDTVLLASSLIPGNENAVYRVINGLTKLGATVVHKGNALVHVSGHAAAGELLYAYNIVRPRAVMPIHGEVRHLVANADLAKATGVDEKNVVLVEDGGVIDLVDGVPRVVGKVDASYILVDGSGVGELTEDTLTDRRILGEEGFLSVVTVVDTRSASVVSHPAIQARGFAEGDSVFAEITDQIVAELEKAMAGGMDDTHRLQQVVRWTIGRWVSRSLRRRPMIVPVVVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ7</accession>
    <name>W4TIZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68766">
        <property type="protein sequence ID" value="GAE68766"/>
        <property type="gene ID" value="JCM18909_1923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8881" checksum="6B781EBC6A3E3481" modified="2014-03-19" version="1">MNASDRGKQHRNHDHRRGHGSILKGDRAMRARELVEQPEASGESQMPEPGQEWETILADLQRRATASHVNNSGQENSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ02</accession>
    <name>W4TJ02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical prophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68139">
        <property type="protein sequence ID" value="GAE68139"/>
        <property type="gene ID" value="JCM18909_1257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21404" checksum="B095F0F21D786E3A" modified="2014-03-19" version="1">MPNVAQILASMRANPRNIDYADLFRVCEEFFGAARNTGARTPSSRPHGPATLGSTSRTTTQGQDIPSPTGAPSNREVEGTVMSQTITDTARYSFRVTWSPEDAEFIATCVEFPSLSWLAGTPEEALTGLRIVVDEVVDDMRANNEPVPEPLSTRHYSGKFQLRLGEDLHRRLVIEAAEQHLSLNQYVTRKLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ05</accession>
    <name>W4TJ05_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68776">
        <property type="protein sequence ID" value="GAE68776"/>
        <property type="gene ID" value="JCM18909_1933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="441" mass="47686" checksum="DEA25A56C66EA68D" modified="2014-03-19" version="1">MSKQANKLDGSLKAKAFTFLSKLAADDAAPGSHIEPVKRCCDSRVRTGRVDQQYRAVLFKLTGEGRNHYVLEGIYNHDEAYDVAPRVELAINPLNGIPEIKRAEPSIDAPNPTASAPTARKPAAPVRETATPVITADRADMLSLGLDANLVDTALALTSEDAVLDMAASLSGWQEAALVGLASGMTPEQVRQELLEPPEEVPEPSKKQHGHAASPRESDVELLESLRSPAAAMEFATIEGVDELRRVIEDGDFGAWRVFLHPTQRRFVNGRWNGPFRLGGGAGTGKTVVILHRAVSLARENPGAGSSSRRSQRTSPMSCPRVWSRSTPPCRGRPRWDSQACTSSVLMPWPTLLSGGRSRRRRGSRRRPGSPTHRCVPAHLPVALARCPRSRRIGGTRAASSPPPTRNRVRASHPAAKYHDARGVSASAPPRARVSAQSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ23</accession>
    <name>W4TJ23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunits gamma and tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68935">
        <property type="protein sequence ID" value="GAE68935"/>
        <property type="gene ID" value="JCM18909_2110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20616" checksum="9B1F109EA2333D75" modified="2014-03-19" version="1">MRREWPQVLEAVKDGGRVAWMVLNKYAQVLEVHGNQATLGFSNIGARESFAAGNYPKVLHDAVVKVLGVDLAFTAVVGEPPAAVRPESHPAEFQSEPAAQEPPGDDPWEQGPHYQDSTRGGEPSDPTHPGRDPQGRPGDRQAISDDASEDAPPPPVTSSHPSEAGDDDSALMPRPRTSLQMSAMRSWNRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ66</accession>
    <name>W4TJ66_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68990">
        <property type="protein sequence ID" value="GAE68990"/>
        <property type="gene ID" value="JCM18909_2169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070567">
        <property type="term" value="F:cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="194" mass="20276" checksum="870E3F353E6D2509" modified="2014-03-19" version="1">MPTMVDEHTPPVVAVVVAAGLGTRFGGPVPKQVTSLTGRAVVAVAVESLAAGGCDEAVVVVKEGMHNHLQLALAASPIPVHFVTGGNTRQESVRNGLRFIAQHHRLSDATTVLIHDAVRPLVPAYVVENVIAAVENGAVAVTPVVDVVDTIRQVDGDTSSVVDRSTCVLFRPPRVLNGPSSLNVTSSYLSRAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ81</accession>
    <name>W4TJ81_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rph</name>
        <name evidence="7" type="ORF">JCM18909_2011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68846">
        <property type="protein sequence ID" value="GAE68846"/>
        <property type="gene ID" value="JCM18909_2011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="48"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="197"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="278" mass="29714" checksum="70F1BBA5D7AA9327" modified="2014-03-19" version="1">MRTPSVIARLSETELLRDGVVTTAVSVWPTTLGKVSETSRIDGRRLDQLRDVRIERGWLSQAEGSVLVSFGRTTVLCNASVTEGVPRWRKGSGLGWVTAEYEMLPRATNERSGRESRKGKVGGRTHEISRLVGRSLRAVVDDKALGENTIILDCDVLQADGGTRTASITGAYVALVDAVNWLRGRGGLVSEPITGSVQAISVGVVDGIPMLDLAYEEDSRADTDMNVVMSGNGDFVEIQGTAEGTPFNRNLLNELLDLAAGGCATLKQAQSEALGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ85</accession>
    <name>W4TJ85_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68463">
        <property type="protein sequence ID" value="GAE68463"/>
        <property type="gene ID" value="JCM18909_1602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="300" mass="33386" checksum="E8158A59FA39B91D" modified="2014-03-19" version="1">MNRISDSHIVRRPLLDRCHADRDDDKANRARWDDPAAQLLLIDPYDKVVMAHDRVVAVPTEGERDDQHDLLLGVVDGVPWFTRRTNEPRPEARSVRAVDLVSVDRELVMSAVAALAWHESNPLCSRCGQSTRITSGGPSRVCPQGHYVFPRTDPAIITAVLDDEDRIVLARQRSWEPHRRSVLAGFVEAGEPAEHAVVREVAEETTLTITSACYIGSQAWPFPRSLMFGYVARATGTIDVGHDELAEASFLSRQEVSDQVNAGRLQLPPTLSIARALIDAWLEHRLPEPESGFDLSAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB9</accession>
    <name>W4TJB9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiazole synthase</fullName>
            <ecNumber evidence="4">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69045">
        <property type="protein sequence ID" value="GAE69045"/>
        <property type="gene ID" value="JCM18909_2227"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="ThiG" evidence="6">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="23607" checksum="BEF786B648B31851" modified="2014-03-19" version="1">MRRFAAGPRQSVFEILQRHRITALPNTAGCYTARDAILTANLAREALDTNLVKLEVIADEDTLLPDPVELVNAAEQLVADDFVVLAYTNDDPAIAKRLEDLGCAAVMPAGAPIGTGLGILNPHNIELIVDRANVPVILDAGIGTASEATLAMELGCDAVLLASAVTRAHNPVGMAQAMKMAVAAGRVARTSGRIPRRRLAQASSPFDGIITERVRGPRENDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC0</accession>
    <name>W4TJC0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68881">
        <property type="protein sequence ID" value="GAE68881"/>
        <property type="gene ID" value="JCM18909_2052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14151" checksum="855A50A81DAD1F4D" modified="2014-03-19" version="1">MTGLARRGGRSRVSATPGRSPQRSRQRIARGMVTVEMAVSLIAATLVVATSCWVVGLVVVEDACRTTAAQVARQVARGDTASARQAESNAPTGAKVSTTTSGGWVNVTVEVDRSLGRIGPVHLRGQARSPMEPGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP3</accession>
    <name>W4TJP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68757">
        <property type="protein sequence ID" value="GAE68757"/>
        <property type="gene ID" value="JCM18909_1914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12648" checksum="BF62EDDEB39145D5" modified="2014-03-19" version="1">MIARHGNEGTFLPFHDLANFVASLERPRRVVMMVKAGRGTDAVIKEITPLLQPGDVLVDGGNAYFGDTRRREEEMRPTGIHYVGTGISGGEVGALRVHQLCLADLRNLTKSSDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR7</accession>
    <name>W4TJR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68379">
        <property type="protein sequence ID" value="GAE68379"/>
        <property type="gene ID" value="JCM18909_1513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="276" mass="29959" checksum="B2E99241AA8B9B1C" modified="2014-03-19" version="1">MRSEGPDGAHWRASYNIIGELTSLTDPTGVSLHATTTAHQAQVTNAAGRVIAADQFDDYGRIVSRTDVFGATSSIDYNTAGLPVVLTDPLGAPTRFDYDRVGHLSAITSPTGLQERYSYDAAGRLASTTDPTGAVTRYLYDADSRLTGIIDPTGVTTEYSWDPVGRLVETRAGEVVTFTADYDVCGRPTRTWDPVTGTRHFRYNTAGRLITAVDAAGQVHRYTWDKRGRLVTTTNAAALTTYRYNQLDQIVESTDPAGGTHRYTWNPAGRLTSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK06</accession>
    <name>W4TK06_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsS</name>
        <name evidence="10" type="ORF">JCM18909_2320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69131">
        <property type="protein sequence ID" value="GAE69131"/>
        <property type="gene ID" value="JCM18909_2320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="9">
        <location>
            <begin position="128"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="376" mass="41718" checksum="57C67824CEA58B3E" modified="2014-03-19" version="1">MGIRKYKPTTPGRRGSSVSDFVELTRSTPEKSLLVAKPKTGGRNNTGRITTRHIGGGHKQAYRIIDFKRYDKDGVPAKVAHIEYDPNRTARIALLHYADGEKRYIIAPDGVGQGTVVVSGLRLTSSRVITCLCATFRSVPRFTLWSCVRVAAPRWVAPPERRCSWSPASKYATVRLPSGEMRMVDIRCRATIGEVGNAEQININWGKAGRNRWKGIRPTVRGVVMNPIDHPHGGGEGRTSGGRHPVSPWGKPEGRTRNKKKGEQPSHRASPQVRQEALIGSLRHATQSEEGPFVDEHLAKKVTAQNEAGTHNVIKTWSRRSMVTPDMIGHTIGVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHVKDDKKARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK19</accession>
    <name>W4TK19_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DeaD/DeaH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68778">
        <property type="protein sequence ID" value="GAE68778"/>
        <property type="gene ID" value="JCM18909_1935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17488" checksum="861E71F869B4BBCE" modified="2014-03-19" version="1">MLAVTLDDVNGFEAGRGPAAPTWFDASVSSKLIGLYDYTPDAVRAVTGGPFALLEYWMRGEPLEALNQFASAIPIFLSDHVPDGYVDPTMPIAAVKQTDLSEDQQGSPGAARVWWRQDGPLSIRTRLRASSPRPATDVCVVLDDNAVSSPNFSHAWHQCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK20</accession>
    <name>W4TK20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68877">
        <property type="protein sequence ID" value="GAE68877"/>
        <property type="gene ID" value="JCM18909_2047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6602" checksum="C1D86A9C126EF7C0" modified="2014-03-19" version="1">MERSRAKIATMGRHLTVDEIEQLRHIFTDIGYVTDPVMAAIGDSGQLGLTRNSTTPAMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK34</accession>
    <name>W4TK34_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-coenzyme A carboxyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68793">
        <property type="protein sequence ID" value="GAE68793"/>
        <property type="gene ID" value="JCM18909_1956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="234" mass="25736" checksum="D5E59437A1D01715" modified="2014-03-19" version="1">MHEVITTVLDEDTFLEIHELFAPNVICGFGRIEGRVIGIVANQPMVNAGTLDIDASEKAARFVRTCDSFNIPVLTFVDTPGFLPGVEQEHDGIIRRGAKLIYAYAEATVPLLTVVTRKAYGGAYIVMGSKTLGADVNLAWPTAQIAVMGAEGAVSILHRRALATDPDPQAKRKELIDEYEATLSNPYQAAERGWIDQVIHPHETRASVIRTLRLLRTKREALPPKKSTETSRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK74</accession>
    <name>W4TK74_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69355">
        <property type="protein sequence ID" value="GAE69355"/>
        <property type="gene ID" value="JCM18909_2563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13342" checksum="8BE36E92DA62AF4A" modified="2014-03-19" version="1">MFGQFSAAERTLWWGGILALGHGVRLGGAEITPVEPDLVRTGEGMSEMTISDALAERGTIPRVLSIAGTDPSGGAGTAADTKSIIAAGGYAMLSSPPWWHRTPKGCALSTPRRPTSWFSNWPLSAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK83</accession>
    <name>W4TK83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68843">
        <property type="protein sequence ID" value="GAE68843"/>
        <property type="gene ID" value="JCM18909_2008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoB-type G" evidence="2">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8359" checksum="8047EB7D7A6FCFAC" modified="2014-03-19" version="1">MPIPTAAPCHTVPTTEPRTGSPKLALVGSPNGGKTSIFNQLTGLHAKTGNYPGVTVSRSTGVCRIGKKMNTASRTFPVPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH0</accession>
    <name>W4TKH0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein-quinone oxidoreductase FixC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69296">
        <property type="protein sequence ID" value="GAE69296"/>
        <property type="gene ID" value="JCM18909_2496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="433" mass="47216" checksum="E9D5D7D4C694E5E1" modified="2014-03-19" version="1">MMSGVRVDSLIERDGQFVGVRAGDDELYSRVVIAADGVNSFLSRDAGLRGPESKNNLAVGVKSVIGLDPKVIEERFQVKNDEGAAYAVVGDCTKGIGGGGFLYTNIDSVSAGVVLRLGDLERSGESSSQLHDHFLTHPVVSPFLAGGELLEYGCHLVAEGGASMQHDLVAPGLLIVGDAAGFTLNTGFTVRGMDLAAGSALAAAKSVDLALRNHDVGHGTLDGYISTCNESFVGRDMNTYRNAQTFLESPEMYNDVGQLAADVMYKIYGLDMTPRKHLLPTVASAVRSSNLSFFPARLNRVQSNEGIVMTTKKVMISGLWPVVLQEIIMTWMRTTATFTLIKTLRAEQGRESYWCEYARRTCTQRSPMALFPWSTQRVWSVALVWWLLRQGRLNGTIPQVQWVSRSEKDEVLVGDGKATWPSLGRRNCGVRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT1</accession>
    <name>W4TKT1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69386">
        <property type="protein sequence ID" value="GAE69386"/>
        <property type="gene ID" value="JCM18909_2595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8337" checksum="497B8EFE083FB055" modified="2014-03-19" version="1">MSAGTMLALVAPTAPAHAETRYRQINQAAITAVAADSATATDPISNTLDGNPDTICTPSGRTEKTRYLTGLYSNWVTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL69</accession>
    <name>W4TL69_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="4">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aat</name>
        <name evidence="5" type="ORF">JCM18909_2477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the L/F-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69277">
        <property type="protein sequence ID" value="GAE69277"/>
        <property type="gene ID" value="JCM18909_2477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042221">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="238" mass="26696" checksum="2A4E3A0191771E69" modified="2014-03-19" version="1">MTVPELFGDPDQWPDDDLIAITGVLSPHLVLAALHEGVFPMPIADDEVSRELRGATAWWSPLRRGILLPSRLKVARSLRKTTKHHTTTVDRAFDEVITRCADPTRPYAWIDDRVMEVYRYLHDRGWAHSVETWDAQGRLVGGLYGVNAGGFFSGESMFHDPEYGRDASKTALMRLVCELGPGLLDVQWSTPHLASLGVIEVDRAEYLALLSDALERPSPQWTSPDDSAWNGDHLLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN3</accession>
    <name>W4TLN3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69895">
        <property type="protein sequence ID" value="GAE69895"/>
        <property type="gene ID" value="JCM18909_3161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="PTHR42825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16576" checksum="2BF3AC916E08CBD1" modified="2014-03-19" version="1">MAMSLRFASADDLTWSSDERIALEHANPRFGAVLADHMAVATWQAGEGWGDDAVVNYHGLDINPGSAVLHYAQEIFEGLKAYRHADGSIWLFRPDQNGERFVRSAERLALPTLPVEDFVTACMRLVEVDSRWSLSPVRVERSPSTCGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP1</accession>
    <name>W4TLP1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69412">
        <property type="protein sequence ID" value="GAE69412"/>
        <property type="gene ID" value="JCM18909_2622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Laminin IV type B" evidence="2">
        <location>
            <begin position="132"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="314" mass="34715" checksum="4328DCF40F002740" modified="2014-03-19" version="1">MTQVDTPASLPGAGASQDEHLAALSGYKYGWHDSDAYAAASRRGLSEDVVRGISAMKHEPQWMLDMRLKALKLFQRKPMPTWGADISTIDFDQIKYFVRAQERQAASWEDLPADIKNTYDRLGIPEAEKDRLVAGVAAQYESEVVYHKINEELGKQGVVFLDTDTALKEEPELFREHFASAVPLGDNKFSALNSAVWSGGSFIYVPKGVHCTIPLQAYFRMNTENLGQFERTLIIVDEGAYVHYVEAALPRSTSRIPCTPRSSRSSSKKRTLVAVIRPSRTGQTTCTTSSPSALTSKRAARWSGSTAISVPKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU3</accession>
    <name>W4TLU3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69930">
        <property type="protein sequence ID" value="GAE69930"/>
        <property type="gene ID" value="JCM18909_3199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8251" checksum="5346525A4C2AB1AF" modified="2014-03-19" version="1">MGRLDHFEKSNAFIMEATVVTLPTSVEIETAIYLDPVDVGRFVDTDELAILMACAQMHGHYHIRCLIMSRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX9</accession>
    <name>W4TLX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69527">
        <property type="protein sequence ID" value="GAE69527"/>
        <property type="gene ID" value="JCM18909_2752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023869">
        <property type="entry name" value="tRNA_Adeno_NH3ase_assoc_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03941">
        <property type="entry name" value="tRNA_deam_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="24038" checksum="9F50AC844B092772" modified="2014-03-19" version="1">METFVAPKEVVMSRFNDNEFVPDDDVDDYDDLDDYDELSDDDYGDYDDDDYDDDLEDASEDEIDFVVALYNDDGERVAVPMEPMLANDFDELITQLRRLPGDAGAVGMVSIDHQFYVIVRVRGRNVQVFLSDATQANDWPIARDVADFLGEDIPDPDDDPETMGDGDMLADAGLGEFDMEAFADADEDSDEILSDIAARVHFGPQFERAANASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY9</accession>
    <name>W4TLY9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maltose operon transcriptional repressor MalR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69408">
        <property type="protein sequence ID" value="GAE69408"/>
        <property type="gene ID" value="JCM18909_2618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8956" checksum="27726885644B14F1" modified="2014-03-19" version="1">MRYTDPPLTSLRQDVELISTMAVQSLMGSIHGNTAFLGERLVQPELVIRGTTAPARVSTVNPSCEPQTPSRAVPMSDTRFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM06</accession>
    <name>W4TM06_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multimodular transpeptidase-transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70010">
        <property type="protein sequence ID" value="GAE70010"/>
        <property type="gene ID" value="JCM18909_3289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="2">
        <location>
            <begin position="81"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="337" mass="36687" checksum="955B10B98D07A25D" modified="2014-03-19" version="1">MSEASRILGYMRSDRHGKLYPLAMFGIVSILTGLLMAGFVVPLAALTGGTAKMVASSMEDLPPELMSTPQAQKSHILMADGSVLATFYDENREYVPLSKISKQMQTAQVAIEDNRFFSHGAIDLKGTARALATNIAGSARQGGSTLTQQYVKQIRIEAAVAAGNEEGVQAAQEPTITRKIQELRYAVAMEKKLSKQQILERYLNIAYFGDGAYGVESAAHHYFGTTAAKLDLAQSAMLAGLVQNPVAYDPVNHPEAATNRRNIVLARMAQLRLISADQARKAEATVFDKSKVFYPKKTAASHRSTRSSATTRIAACCRCRVWARTPRSGPRWSSVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM63</accession>
    <name>W4TM63_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-ribose pyranase</fullName>
            <ecNumber evidence="2 5">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsD</name>
        <name evidence="6" type="ORF">JCM18909_3355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodecamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RbsD / FucU family. RbsD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2 5"/>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70070">
        <property type="protein sequence ID" value="GAE70070"/>
        <property type="gene ID" value="JCM18909_3355"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01661">
        <property type="entry name" value="D_rib_pyranase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023064">
        <property type="entry name" value="D-ribose_pyranase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37831">
        <property type="entry name" value="PTHR37831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13984" checksum="BD6F9F2CF78E8B5D" modified="2014-03-19" version="1">MKKSGLLNPQLCAAVARLGHTQTFVVADAGLPIPHEVPVIDLAVVLGTPRFQEVFDAILDEVVVEGVTIAHEALGHEPESWVRERIEEVHTVSHEDLKKKALPNVSFVVRTGETTPYSNVIVRCGVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM95</accession>
    <name>W4TM95_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69846">
        <property type="protein sequence ID" value="GAE69846"/>
        <property type="gene ID" value="JCM18909_3104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025289">
        <property type="entry name" value="DUF4081"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13312">
        <property type="entry name" value="DUF4081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="20077" checksum="E5449E63205B6D22" modified="2014-03-19" version="1">MYERLAQIGPDTWGRPREVRSCQPLLAMSDRPRVVPDARVVRIDERHFEPYFRAAVAMYTEEVGVSPLDPGDGYRRHMLELVRQGRGLGIVDDGDVRWKSDVAVTWGNVCQIQGVWMDPAWRGRGLAAPAMAAVVELARRDHDTVSLYVNDFNTRALRTYRRVGFERIGTMATLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB8</accession>
    <name>W4TMB8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Argininosuccinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69553">
        <property type="protein sequence ID" value="GAE69553"/>
        <property type="gene ID" value="JCM18909_2782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024073">
        <property type="entry name" value="AS_multimer_C_tail"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="13799" checksum="39CC9CC99A5C9D05" modified="2014-03-19" version="1">MIRESLTHWVANAVTGSVTLKLGRGWDYSILDTTGPNFSYHSEKLSMERVEGAAFGPTDRIGQLTIRNLDIADTREKLELYSAQGQLTSHADLVGQLETGGASAIASNGDDDDDSQKALDAAAMEVGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN9</accession>
    <name>W4TMN9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exoenzymes regulatory protein AepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69439">
        <property type="protein sequence ID" value="GAE69439"/>
        <property type="gene ID" value="JCM18909_2654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="48"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="35949" checksum="BDC30AD8BE34D3EB" modified="2014-03-19" version="1">MLLLHNARILDLTDGSTGEPTDVLLSDRVLALGPEAQQQARSARVRSIDLGGRLLMPGLWDEHVHVGQWALASRRFLVSQTASCETVLEEVATHVKRREGSDEPILQGFGFRPSLWGSNPNARQLDAVTGNRAVILVSADLHSSWCNTAAMRKLGIEGDGFLREQTSFDVQTQLSQVNPHVLDGWVGSCSTAAARLGITGIRDMEFSTDVETWLQREADGRCPLRVEVSVYPERLDEAIAQGLATGQAPVTDKPGPSRVAMGPLKVIVDGSMSTRTAWCMDSYPAGAGPDGAGIDSVTPEDLVDLMNRAKTGNLQCAAHAIGDRAAKEVSMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN38</accession>
    <name>W4TN38_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69619">
        <property type="protein sequence ID" value="GAE69619"/>
        <property type="gene ID" value="JCM18909_2857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="276" mass="29398" checksum="AA5B1A3CD4C495AA" modified="2014-03-19" version="1">MSEPPQWLRDAIISTEHDWARYPDATPGREALAAMHGVPTDMVLPTAGAAEALPLVATLEPRHAIVVHPQFTEPEAALRAAGISVGRHILNMSDGFALDPDLVPDDADLVVVGNPTNPTGRLHPATDLLALRRPGRVLVVDEAFMDATDESQSLIGSDMDDLLVLRSLTKTYGLAGIRAGYVVGDSQLVAQLAAHQTPWSVSTPAIAAMIACTCEEARRFRTELRDDIPAARADLVDKFKGLGLSVVDSEAPFVLVNTSSSAGIRYASPLPSVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNC4</accession>
    <name>W4TNC4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70241">
        <property type="protein sequence ID" value="GAE70241"/>
        <property type="gene ID" value="JCM18909_3539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19130" checksum="CDCE695886117137" modified="2014-03-19" version="1">MARYVGVSNFVGWQAATAATWQRATGTRTPLVSNQVEYSLLARRAEIEVVPSAQHHGMGLLAWSALGRGVLGGRYRHGTPKDSRGGSDRLSWFVQPYLTRKSNAVVEAIVKAADGLGATVPQIALAWVRDAPVVASALVGPRTTSQLEELLGADEVSLPKEITSALDDITGGPNLAREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ9</accession>
    <name>W4TNJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA-dependent lipid II-amino acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70535">
        <property type="protein sequence ID" value="GAE70535"/>
        <property type="gene ID" value="JCM18909_3873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="218" mass="24640" checksum="93220FB4CFEF050B" modified="2014-03-19" version="1">MPISARSVSVSTMLEFIAARGSASFLQTPAWARVKSEWRGERVGFYDGDELTGVGLILYRKLPKLPRYLAYLPEGPVLDWSRDDIAEHFDALVTHVKKRQAFAVRIGPAVVHRIWGTKTIKTAIADDNITSLTEVEPDVVTPEGEHVVSVLKQGGWITDETGQGFAAGQPQFNFQLSLRHEDGTQKSEDELLKGMNQLWRRNIKKSCQIWRRSETWHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL2</accession>
    <name>W4TNL2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70550">
        <property type="protein sequence ID" value="GAE70550"/>
        <property type="gene ID" value="JCM18909_3891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13588" checksum="9F32E1AC9956A8AD" modified="2014-03-19" version="1">MVSGGERQRLAIARILIHPKPLIVLDEATSAMDSISEERSMAAIRQVASDSILIIVSHKLKTLATADEIIVLKSGQLTERGPLAELVNDDGVFNRLWKGSRPWTKSSHVDRDNSVNMTGLPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNQ9</accession>
    <name>W4TNQ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urocanate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70033">
        <property type="protein sequence ID" value="GAE70033"/>
        <property type="gene ID" value="JCM18909_3313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15382" checksum="E9AC4384D8280CD5" modified="2014-03-19" version="1">MNIALRFNKMVRDGEIGPVMLGRDHHDVSGTDSPFRETANIKDGSNVMADMATQCFAGNAARGMSLVTLHNGGGTGIGNAINGGFGLVLDGSERVDNVIRSSLLWDVMCGVARRGWARNAHSIETATEFNHEHDDARSPCPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY4</accession>
    <name>W4TNY4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000067">
        <property type="protein sequence ID" value="GAE70695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70695">
        <property type="protein sequence ID" value="GAE70695"/>
        <property type="gene ID" value="JCM18909_4073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14605" checksum="5BD550334D7644D8" modified="2014-03-19" version="1">MTYSVPEHPLPDWLAQLVSPLDDKLGVKVREISPHRCVVTAPLDGNTQPMGLWHGGGSGVLVETAGSLAAMAHARTFEHSAVGTELSVSHLRPPHGHQIIATATAVHLGKRATTHIVEIVDDEGRICAIGRMTCQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPB6</accession>
    <name>W4TPB6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70561">
        <property type="protein sequence ID" value="GAE70561"/>
        <property type="gene ID" value="JCM18909_3906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="270" mass="29516" checksum="7CF9FC5CC89874AC" modified="2014-03-19" version="1">MLEVESVRVDVSRVGRVLDDVTISAEPGVTVVTGRSGCGSTTLLRLIAGFHDRQVVRRQGVIRLSGRRIDTMSHAELRPQVAVVGHRPTGAMGCGDAERDRVIEELGLRDWCDRPAARMPACVAARMALAEGISSGAPVLLLDQLLAPMTSKWRPRVAACVVQVARTGRIVLWAEHALDYALGAADSVVEIIDGHARQVEASSWSSTNLPPPRCRRSPPGLAREYSPARSKPTPVWLRQRSPQCHRPNRSSPRGRYSPASILRPCAYRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPF3</accession>
    <name>W4TPF3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70084">
        <property type="protein sequence ID" value="GAE70084"/>
        <property type="gene ID" value="JCM18909_3372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="421" mass="45122" checksum="8E85BF36D7105D9D" modified="2014-03-19" version="1">MNVTTLQTQGERAVTTSAHTIEPPGHDGAGRWPLSIVLMPPPSAESVLAALTQEAIYLAGTDHLRSGAVGCAHVTVRALENRRPVPPQDPFAASCASALDRACAHHAPLFMRLERLLITPGGVLALLHPTSRTPMSSAPTRSATNSDPTPTEKASSAPETSGTCPCSTSAAPSSTPKISWPGATNNSLRPHGPSPMQRCVPTKPLPRRCAPASATRPRSGGRSDRTTLMQPVGWVTSRVSSPDRIAHERPSRPDKSGSVKVTGKRTSLLLGENSSDHLRGCAVSNRRWFLVQTARTRWSLVQHPGAIDRVALFQVTHDAPQKAVRDLDVLGSDAVGAGYSHSDLREEFEKSVTALRRASTQSRRNSGISRGDDNGVEDIEPSSDHRLGSQHKLSCSWHLRPDSGMPWSSCRNATRLSPKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPH1</accession>
    <name>W4TPH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70626">
        <property type="protein sequence ID" value="GAE70626"/>
        <property type="gene ID" value="JCM18909_3984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16403" checksum="63562F3DB72330C4" modified="2014-03-19" version="1">MAALSQSVKATYWLDDSKRVVGTTAEVSKLRSTGSSGPAIGNGSDTYATQGSTEGCEKITKRVGESHNSLFPHGPDKKIVKPLAHEDQPGPISSSRSSRRGVLAVHVPCDVAGIQGHRRFESGSFRVVAMAAALESPDPCISGDFLSRHPPVYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK2</accession>
    <name>W4TPK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptide transport ATP-binding protein OppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70432">
        <property type="protein sequence ID" value="GAE70432"/>
        <property type="gene ID" value="JCM18909_3750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="23720" checksum="4753721CF3CA79D8" modified="2014-03-19" version="1">MLKVMMALRQPDSGTVRFRGTSLTDANAIRELRRSAAMVFQDPRSSLDPRMSIGRAITEPLRSPVARRTTRQQRKDRLAKVMVDVGLDPESASRFPHEFSGGQRQRIAIARALVTEPDVLLADEPVSALDVSVRAQVLNLLNDLVRERGLTMIFVSHDLGVVRHLCDTVAVMSVGRIVERGKLADVYRDPQHVVTQELLRAVPRIRVDDSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM1</accession>
    <name>W4TPM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Corrinoid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70457">
        <property type="protein sequence ID" value="GAE70457"/>
        <property type="gene ID" value="JCM18909_3784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="132" mass="13590" checksum="964B5ECADD580C77" modified="2014-03-19" version="1">MVLILVFMAVLLFVLGTALSIGSVQVPFTMVWKVVAHRVFPEGVISVEWTPAIDRIVADTRLPRVLLAAVAGMALTTVGTVVQALLRNPLASPTILGVSSGAATGAIAVMRFGLLIGGTVSLGLAAFGGAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPU0</accession>
    <name>W4TPU0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">recF</name>
        <name evidence="7" type="ORF">JCM18909_3888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70547">
        <property type="protein sequence ID" value="GAE70547"/>
        <property type="gene ID" value="JCM18909_3888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0742">SOS response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="36518" checksum="F087F8A8EBEF1104" modified="2014-03-19" version="1">MRLGADQSVVRGRVRAGTDDARSLLLEVEINARRANRARINRAPLTRPRDILGVLRTVVFSPNDLAVVRGDPSDRRAFLDGLVVTRWPRMAAVKSDYERVLKQRNALLKSLSGKGRSAGAEIGATMDIWDNELATIGAELLSARLDTLSAVMPLTSAAYREIAPVNDLTTASYKSTIDLEGLWSPPQERESSTPIDRKELANRFLDTLAKRRADELIRGVTLVGPQRDDIILHIGEMPAKGYASHGESWSLALALRLGSFQLLRDDGIEPVLVLDDVFAELDASRRDRLASSIVQADQVLVTAAVASDVPEILRGERFDVGGGQVLAYEGSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPU6</accession>
    <name>W4TPU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70254">
        <property type="protein sequence ID" value="GAE70254"/>
        <property type="gene ID" value="JCM18909_3557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="16454" checksum="D212E9BA5EC3D7BE" modified="2014-03-19" version="1">MILGSGIQEGLLLKPVTYSWAYNLYNQAVANTWFPNEIQLDEDLADFARMTPDERHALTHLMSYFNPNELLVNKALAFGVYPYVNAAECHLYLAKQMWRRPTTVWPSSMSSKPSRLTATRPTDPTSTSPQWLARKLSRWRSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPX6</accession>
    <name>W4TPX6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70284">
        <property type="protein sequence ID" value="GAE70284"/>
        <property type="gene ID" value="JCM18909_3592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16405" checksum="058E669EE67E5D3E" modified="2014-03-19" version="1">MRRRVCLPPICTPGIDRSPMSRIRRPLQLMRTRSRSVVMSTLLSESLPPLARRGPGDTVEATVSPTLSAIPDTTRHADRSPSFASEGIVNPPSELLSAPERHPQKPRVGGPGRNRGHSSPQTWAGLVQRQRYGDSPRRCLSSRQQGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPZ8</accession>
    <name>W4TPZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70304">
        <property type="protein sequence ID" value="GAE70304"/>
        <property type="gene ID" value="JCM18909_3612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23673" checksum="B74E5217E8BC145E" modified="2014-03-19" version="1">MVIEGARQVGKSTLTGMIDNANTTFTTMDDDLTRTFAHDDPAGFLSSAKEGRLVIAEIQRCPELILPLKAVVDNDRRPGRFVLTGSANLLRLPGAQDSLAGRAMTARLHPFSQGELEGHKEDWVSWLLSPDRRTAPEADRSDVITRLTVGGYPLVQSMSPRVRTAWLKDYANRLVQQDASDMAQTRIPILGQLLQLLAAAPGPSWSRTGLRRNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQA3</accession>
    <name>W4TQA3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70573">
        <property type="protein sequence ID" value="GAE70573"/>
        <property type="gene ID" value="JCM18909_3923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6789" checksum="062623B687DE0D05" modified="2014-03-19" version="1">MDRLAQRLLIGDSRSVILAEIGVGGNLVDTILESLDLVLNLGDGARRINSDDRRLAISRPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQB2</accession>
    <name>W4TQB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exodeoxyribonuclease V gamma chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70588">
        <property type="protein sequence ID" value="GAE70588"/>
        <property type="gene ID" value="JCM18909_3938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041500">
        <property type="entry name" value="RecC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17946">
        <property type="entry name" value="RecC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecC_C" evidence="6">
        <location>
            <begin position="727"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="955" mass="103936" checksum="620D1F34747B5493" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQG1</accession>
    <name>W4TQG1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloride channel related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70464">
        <property type="protein sequence ID" value="GAE70464"/>
        <property type="gene ID" value="JCM18909_3791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="341" mass="35069" checksum="C08ADEF378144F13" modified="2014-03-19" version="1">MATSRIRFVAVVVLTGLASGLIGGLTSELSHLIEVCAFGVPFSSSTTGVGEVVMWRRLVAPIMGALIAGLTWRWLRPFPSGSITSVRQAIDSPTRLRPVETIVDALAQLVVVGSGSSLGREAAPRQMAALAAQGLSDTFRVDAATRRVVLASAAGAGLASVYNVPVAGALYALELTVRPDLRTKRGWGQVGIAGVISVLSTVTAWLLNHDRPIYRSPAATVTGTGLGWVVLVVAVSTVVGAGMGVLFGEMKRRVPITSRLWWTVPLGSAGVTTIALAAPQVVGNGQVIVNLVLAHPVAPASLAILLVGKILATTMALRSGAAGGLLTPSLSAGALVGAWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQK4</accession>
    <name>W4TQK4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70509">
        <property type="protein sequence ID" value="GAE70509"/>
        <property type="gene ID" value="JCM18909_3837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="124"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25013" checksum="8E66DABC325891FA" modified="2014-03-19" version="1">MARVTCDLVNKPISITPFGVDTEILTPLDKRRDANGGDGVVRIGTIKLSTPNMGSANSSVPSVGSMMSGLIPSFVSGAAAQTRIPSRFWPAVLSRTVRWSFAVPLIILRLEMPWAVWTSLPPYRLDSESFGVAIIEAGACGLPAVVSDADGPAEVVEDGVTGLIVPRGDVIASATALMQLVDDVELRRRMGRAGRDHVVETYSWEHSLDLMEQAYRDTIDDAARQHCSGRHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEE6</accession>
    <name>W4TEE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67340">
        <property type="protein sequence ID" value="GAE67340"/>
        <property type="gene ID" value="JCM18909_388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12836" checksum="4E1A912793E9B8B3" modified="2014-03-19" version="1">MGFITYTSVVSDPIVVEAEDRWVEIVTDLDRQEANSDHNYRRQDRRGVRFCSWAAYNAFGNQEAGAMPSAEGIVCESETATEHEQAIRAASKLLVELIKELPPVQREVFIAVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TER7</accession>
    <name>W4TER7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proline synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_52</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67022">
        <property type="protein sequence ID" value="GAE67022"/>
        <property type="gene ID" value="JCM18909_52"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8840" checksum="77785FEDF43E6DE1" modified="2014-03-19" version="1">MRGLMTVALNSSDQRAVADCFDLVVATQEKLRQEVGDTSDWSELSMGMSGDLEIAIAHGSTQVRIGTDIFGARDPARTWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEX8</accession>
    <name>W4TEX8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67346">
        <property type="protein sequence ID" value="GAE67346"/>
        <property type="gene ID" value="JCM18909_395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="15392" checksum="963241ED5733D2CF" modified="2014-03-19" version="1">MDTLSIDIETFSPPPARQSGYLPYAEHPDFDLLLFGYAVDGGPVEVVDLASRQTIPEEILAVLVDPDVIKWAYNASFERVCLSAWLRRHRPELLSDGFLDPAQWRCTVVWSVYLGLPMSLDAVATVLKLDVQKRRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF17</accession>
    <name>W4TF17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unnamed hypothetical gene product in the file</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_43</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67013">
        <property type="protein sequence ID" value="GAE67013"/>
        <property type="gene ID" value="JCM18909_43"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="27852" checksum="5E59C8B17CFC805A" modified="2014-03-19" version="1">MFSAHDDDGQGVLVIVLSHGAASDPASWDRLAGEVNHLHSETVIARGGAGQNTGRLSGLYRPVTGPENGGPSLAPWVALVNDGSRAAVAEARRILDAVDMSALSGTPVAGPSFRLHWIDDTAAGRVRTWPLPWPGRRDKAGWSTTVIAWLLTLFIALTGLLIAVLLFQNVPPSPPPPPVPTSASSNRSAHSSSSPTPSQSSGQSASPSHSSKSPSPSKGQTPSPTSTSPSTGRSGSPTPSNNPSTSPSRTPSMQSPGAGTGTSSGTPTGRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF37</accession>
    <name>W4TF37_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginine deiminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67396">
        <property type="protein sequence ID" value="GAE67396"/>
        <property type="gene ID" value="JCM18909_453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13561" checksum="4206E1195D4A542E" modified="2014-03-19" version="1">MTLYKPVVDTITPLVLEPSSEAAGFSVRVDDRHFTDVVASSLGLDGLRTVETGGDCWEAQREQWDDGNNVVALEPGVVVGYDRNTATNALLAKAGVEVVEIKAAELGRGRGGGHCMTCPITRDPVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF45</accession>
    <name>W4TF45_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67147">
        <property type="protein sequence ID" value="GAE67147"/>
        <property type="gene ID" value="JCM18909_187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5814" checksum="24220A80A46AB4D2" modified="2014-03-19" version="1">MYLVMGDDALRDELVKSRKAARRKANKPPEVSPLDTTDDDELGTDPRLEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF47</accession>
    <name>W4TF47_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">carA</name>
        <name evidence="6" type="ORF">JCM18909_83</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67048">
        <property type="protein sequence ID" value="GAE67048"/>
        <property type="gene ID" value="JCM18909_83"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="496"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="632" mass="69431" checksum="F4E54ED133747EEA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFC1</accession>
    <name>W4TFC1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67665">
        <property type="protein sequence ID" value="GAE67665"/>
        <property type="gene ID" value="JCM18909_740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18092" checksum="3F2E769C789562FA" modified="2014-03-19" version="1">MVGDDLGGAARLFDDGLFDGGVGPQLGDLLIGRVVFVSVLDCDDVEVGIGRLAGGVILVENLVAVQPGVCGEVVIDDGTIDASREAAVWAASIALTFTLDWLAMTSAGVDNAEPLPRSFNKPASCNTSRARPWLVASFGMAIVAPAGSWESRWYFFSSRYLAGRRRSQLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFC8</accession>
    <name>W4TFC8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permeases of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67466">
        <property type="protein sequence ID" value="GAE67466"/>
        <property type="gene ID" value="JCM18909_528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="269" mass="28942" checksum="0BCBB09C03EF2A98" modified="2014-03-19" version="1">MLMSEDRSRVVRKVIVASFLGNFVEWFDYATYSYLAVIISRVFFPQGTSRDALVQTFVIFALSFLLRPIGAVLWGCWGDKYGRRWSLSVSILMMAVASFLIGCLPSFAVAGAFAPIGLLVCRMVQGFSASGEYAGAATFLAEYAPACRRGCYVSIVPASTAAGLLMGSLSAAMIEGCLPQGAVGTWGWRLPFLAAGPLGLLARHVWLELEDSPVYQELSESETGAAVGLGPLKTLLREHQRSLLVSIGVASLNAVGFYLVLTYLPTSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFG7</accession>
    <name>W4TFG7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67178">
        <property type="protein sequence ID" value="GAE67178"/>
        <property type="gene ID" value="JCM18909_220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="283" mass="31407" checksum="2D5CBBA3054B87A6" modified="2014-03-19" version="1">MRGFAQDDSHTYCTREQAPGEIKKQIEFFFLSILADFGLNDFYLELSTRESDSAKEEKFIGSDEDWQVATDTLDQVCRSTGLQLVPDPGGAAFYGPKVSVQVKDAIGRTWQMSTIQYDFNQPERFDLEYAAADGTHQRPIMLHSAKLGSVERFIGVLTEHYAGAFPVWLSPVQVRLVPVAEAFNDYVTGFAEVLGSRGIRVETDLSSDRFGKKIRNASKDKVPFILIAGGEDAEAGAVSFRLRDGSQVNGVVLDEAVRIIAAWDSRHRNDDPTSETLRGVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFL4</accession>
    <name>W4TFL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protoporphyrinogen IX oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67765">
        <property type="protein sequence ID" value="GAE67765"/>
        <property type="gene ID" value="JCM18909_848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13110" checksum="E16DCD45F50CFC51" modified="2014-03-19" version="1">MRQVTNLSTTWHLAKPTFRIAMGRQRGTPIDDLSDDDLVAMSVAELRRLGLALDPHDYVIERHRGAMPQPAPGHRERMAQLAATLNGTGLHVGGAGIDGAGVGTAIAAGRRLARHITSKEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFQ7</accession>
    <name>W4TFQ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transport system permease protein OppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67805">
        <property type="protein sequence ID" value="GAE67805"/>
        <property type="gene ID" value="JCM18909_890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850705" evidence="7">
        <location>
            <begin position="22"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="81"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="409"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="613" mass="66617" checksum="DFD1356F5B7B07C6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS3</accession>
    <name>W4TFS3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66974">
        <property type="protein sequence ID" value="GAE66974"/>
        <property type="gene ID" value="JCM18909_2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE66974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7715" checksum="CB54493081CAB6E0" modified="2014-03-19" version="1">MSVRLVVTDDHPIMRQALAGYFSRVEEMEVVGQATNGREAVELVDQLLPEVVLMDSRCLRWTVSQLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFU8</accession>
    <name>W4TFU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67845">
        <property type="protein sequence ID" value="GAE67845"/>
        <property type="gene ID" value="JCM18909_935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="7897" checksum="35C8502E219B0CC5" modified="2014-03-19" version="1">MNIDWTSLGLVSVVTVVATVLIVSVVSGGALMLDRAHARTEAGSDGAAGLVALGWTAIGVAGLIVLYGLYLLIPYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY5</accession>
    <name>W4TFY5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67885">
        <property type="protein sequence ID" value="GAE67885"/>
        <property type="gene ID" value="JCM18909_977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="14317" checksum="39A4A82D8F9CF94E" modified="2014-03-19" version="1">MTLLCPCESGRNLDQCCGPIFDDPRHAETAEALMRSRYTANTLGRWNHLWATWHPRTRPDVVDSQGLEWTGLQILATKDGQPGDTTGMVEFRASYRAGKRHNVLHEVSRFQRRAGRWMYVDGDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG16</accession>
    <name>W4TG16_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67731">
        <property type="protein sequence ID" value="GAE67731"/>
        <property type="gene ID" value="JCM18909_811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="93"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21477" checksum="B8CCEC27D6856A71" modified="2014-03-19" version="1">MTTSRWSRFFDDRIAEPDELAAKDGVEVGEVAMRSPKCGMSCSGETGSKDPKFHAGWFYPGDLATWDEHEFVTIVGRKDEMIISGGENVFPTQVESVLESHPSVLESIVVGLPDPEWGQLVVAYVVADPDAAAVTADELEAHCLASEDLARFKRPRAYRFVDKLPMTPTGKKKHVEATAMACREADTFVRPRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG38</accession>
    <name>W4TG38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ornithine carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67398">
        <property type="protein sequence ID" value="GAE67398"/>
        <property type="gene ID" value="JCM18909_455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21331" checksum="B4252351419D0445" modified="2014-03-19" version="1">MLADALTMREHAEKPFHEIKFAYVGDGRNNMGRSLLLLGAKLGMDVRIGAPEGLQPEAELVERCREWAEQSGGKVLVTASAEEAVRDVDFIHTDVWVSMGEPVESWSERVGTLLPFQINDALVKAAGNPRVKVMHCLPAFHNSETAVGAEVAKTYPELASGIEVTESVFESPACIAFDQAENRMHTIKAVLVSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG74</accession>
    <name>W4TG74_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphotransferase system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67532">
        <property type="protein sequence ID" value="GAE67532"/>
        <property type="gene ID" value="JCM18909_597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="7983" checksum="27D0B6FA2F04DC0B" modified="2014-03-19" version="1">MSKAEQILAALGGDDNIDDLEACITRLRVEVDDPSLVDESALKAAGAFGVVQQGTSVQVVVGPEADTLVEDIEDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB6</accession>
    <name>W4TGB6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxalate/formate-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67194">
        <property type="protein sequence ID" value="GAE67194"/>
        <property type="gene ID" value="JCM18909_237"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="377" mass="41042" checksum="ED973C08BED164F4" modified="2014-03-19" version="1">MRLSSQSSGYVVSRSRHVHAASPVYRMVGAVTKASDASLGWVTTCAVLVSGLLTYVAGIVRQQVGTRWMYVVATVLMLVSLAVVLVNPRSLPIAYVWALLSGASSAFTYSPSLTAVQEWFPRRLGLVTGLVNASFALPAAAAAPIVGGMLRNWGFTATVLTLMVAVALTQMVVIFLSTPYWLEKRHAEELAVARREISGPAVTTAQAARTPAFWQVWAMWFAGGGAAITMMTFAATYSAHLNDIGVHVSAVAAVTAFVSGNGLIRVVNAMLLDHIGPTVIGGVTSVTLAFGYMLLGVRRQWLGTHRRGFSGWRRFGDYLHDLPCATDAPFRYQALWSDLRPGFQRLRYFLVLLPDRCSVLIWLNGWDMAWYSSTSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH6</accession>
    <name>W4TGH6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="10" type="ORF">JCM18909_1171</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68060">
        <property type="protein sequence ID" value="GAE68060"/>
        <property type="gene ID" value="JCM18909_1171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="98"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="604" mass="65355" checksum="EA0C5D5BFF5BF859" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ3</accession>
    <name>W4TGJ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67652">
        <property type="protein sequence ID" value="GAE67652"/>
        <property type="gene ID" value="JCM18909_726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="9064" checksum="2C90BEF7CE9562F4" modified="2014-03-19" version="1">MSDDVATTRRMQEMYAEPIKLSSSPNGWLRSGPPGCRWRGRCHRRMPRVSPRRWSMPERTFFRHPWHDGVGGARGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP5</accession>
    <name>W4TGP5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68140">
        <property type="protein sequence ID" value="GAE68140"/>
        <property type="gene ID" value="JCM18909_1258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5703" checksum="34C7761FA07098DD" modified="2014-03-19" version="1">MWYQGEVTGVLEVGVLGMAAGPIRCSRRRKGEGKTRLAVSTCIADVVGLPRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGQ0</accession>
    <name>W4TGQ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68145">
        <property type="protein sequence ID" value="GAE68145"/>
        <property type="gene ID" value="JCM18909_1264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11801" checksum="2DEF23160396F10B" modified="2014-03-19" version="1">MADIAWFTPTGGVMMVSILSHKLCVAVLIAAFALPLAFVVWRAIAGTGSWWRKILRGLGHLVVILLAQALLITGVFLYINREYGFFSRHGLTCWERSDQRLRPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS2</accession>
    <name>W4TGS2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TsaD/Kae1/Qri7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67623">
        <property type="protein sequence ID" value="GAE67623"/>
        <property type="gene ID" value="JCM18909_696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12105" checksum="97D4BC152D412EAA" modified="2014-03-19" version="1">MRFGGVVPEVASRAHLEAIVPVLDKAASTAGVDLSELDGIAVTAGPGLAGALVVGLSAAKALASWLNKLCTASTIWLDMSPSTCLSTVSCQCHVGSARVRRPYQLAAGKRHRHRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGV8</accession>
    <name>W4TGV8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67767">
        <property type="protein sequence ID" value="GAE67767"/>
        <property type="gene ID" value="JCM18909_850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="61"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20673" checksum="DA0695F96B726C5B" modified="2014-03-19" version="1">MTETMCADEGGTDPFVLPARHHPVNRPDPAMVRILDEQGHLTTHPDFPVDLVDDDLVKALEMMVMTRRLDVEATALQRHGELGLWPPLLGQEATQAGAWLALRQGDQVFPTYREQGLAHAMGVSLADILGAWDGTSHCGWDTVATHFSAYPVMIGSGTLHAVATPWVSSVTSRLEVIRLPCWISTVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH30</accession>
    <name>W4TH30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67738">
        <property type="protein sequence ID" value="GAE67738"/>
        <property type="gene ID" value="JCM18909_818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11536" checksum="BA165F273429A4D9" modified="2014-03-19" version="1">MALQGGILVIMSGNLLLFLLFFVGLVATTTSLMRAQRQSRELEAQRAKAIQAKVSQMRQETEEDVTTFGEALRDLDMEMVGKDISLTVARTGIWPLIAMTAPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH35</accession>
    <name>W4TH35_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67743">
        <property type="protein sequence ID" value="GAE67743"/>
        <property type="gene ID" value="JCM18909_824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14184" checksum="E9A6FA4F95A51600" modified="2014-03-19" version="1">MTTAADQTAEVGKPFGDTAHITGTVPEGAHITFKLSHKGLLPNMCGDSVITTKPVAVPAGNHIQPIDIASPKVTVGQAGTYYWVETLTDNNGKVLAQGKCGEHAETTTVTAPVVPTPTPTMVPVGPSHPRLMPHTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH55</accession>
    <name>W4TH55_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68300">
        <property type="protein sequence ID" value="GAE68300"/>
        <property type="gene ID" value="JCM18909_1428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22504" checksum="6F4009012923065C" modified="2014-03-19" version="1">MRKEYGISGFTAVFSGTHANYVGLDLIVDAARRLPGVNFLLVGAGARKQWAIEEVAKLRLTNVTFHDQVPKSELVRILSACDVGLHTVSPQSVFDKGMSPNKLYDYMAAGLAVVSNAKVPIRDVISDDEVGACVDPTDLVAGIERVRDADEATMKRWHERARELMANKYSLQASVNKLATVLEKSAIPLSARQFSRTTPPPGPEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH75</accession>
    <name>W4TH75_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67783">
        <property type="protein sequence ID" value="GAE67783"/>
        <property type="gene ID" value="JCM18909_866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16109" checksum="BCE8ED4370CBFB9A" modified="2014-03-19" version="1">MNGLVPQFFGGKLRGHVMVQGTDLASVELHNVGRTSAMIFQNPRTQFFTSSVRTELAFGLENYGSIRLISAKLSPVRFPEPVSLTCSTATSTLFQEENFSGSPAPARWWLMSTCFFSMNQPRTSRLRGSKIFALSSPSSKLPTRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF7</accession>
    <name>W4THF7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_85 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67589">
        <property type="protein sequence ID" value="GAE67589"/>
        <property type="gene ID" value="JCM18909_661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="Glyco_hydro_85"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_85" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12827" checksum="C4CAF8AB52E8065C" modified="2014-03-19" version="1">MAKYFGYDGYFLNEEEGNLQDSRFRPFMSYLTSKGLYTQWYTNTPGTWSSSKAGLLDHGRIMNSVFLNYNWPGTQDRSVEAAKAEGYDPYQFLFFSVSRRIRRGSTASIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT8</accession>
    <name>W4THT8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67739">
        <property type="protein sequence ID" value="GAE67739"/>
        <property type="gene ID" value="JCM18909_819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="4"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="123"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="511"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="589" mass="63904" checksum="EA31E830E4749586" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU7</accession>
    <name>W4THU7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-proline glycine betaine ABC transport system permease protein ProV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68092">
        <property type="protein sequence ID" value="GAE68092"/>
        <property type="gene ID" value="JCM18909_1206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26817" checksum="02224662F0B75F5F" modified="2014-03-19" version="1">MRLFSALDPLIRREMQDQLLELQGALNKTIIFITHDLNEAMYLGDHIAVMRNGRVAQIGTSDEILTQPADDYVADFVQDVDRSRVLTASAVMRPTEAVVSRSAEPRRVQRILEQREWAGVFVVDEHRRLLGTVGDQEVIEAARRGDRSIANAVETSGILTARTDTPLSEFFAPTSNARVPLAVVDEDFHLMGVISRVTLLDAMSRARDEAGEGSVMSLENTGKLPIIRDTDTGNPVGLPPADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY1</accession>
    <name>W4THY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68033">
        <property type="protein sequence ID" value="GAE68033"/>
        <property type="gene ID" value="JCM18909_1139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic_M" evidence="2">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="168" mass="19012" checksum="71E8D806D430EB86" modified="2014-03-19" version="1">MLAAVISGLKVTRQSFADQRLLVYGAGTAGTGIADQIRAAMMSDGLSQQEAIDRIWLIDRDGLVTDDMEGLPDYQEPYAKPVEKTRHWAHTNRHIGLIETIRRVHPTILIGTSTDHDAFTQQVVEEMCREVERPLIMPLSNPTEKIERCPPMSLRGQRGKLWFPSEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ0</accession>
    <name>W4THZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67784">
        <property type="protein sequence ID" value="GAE67784"/>
        <property type="gene ID" value="JCM18909_867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9800" checksum="949FB80CC1ECA48B" modified="2014-03-19" version="1">MIAEHRLHLFRGLVDDVHRVSNGQIVERMSGSSLFALTEGDLLERGLRSLDVNSVDLPAPPQAPAPLTPVPRGKFMRSDPASVSCTKIPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI13</accession>
    <name>W4TI13_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JCM18909_1286</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68167">
        <property type="protein sequence ID" value="GAE68167"/>
        <property type="gene ID" value="JCM18909_1286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE68167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="12929" checksum="B13AA5F41D5654F6" modified="2014-03-19" version="1">MVAAAVILDDRRSGRIAGLADSKTLSAAKREALFNVIMDKALAVSWVRVEADECDRLGMQEADISGLRRAVVRLGVEPGYVLSDGFPVDGLTVPDLGMWKGDSVCACVAAAPSWPKWPGIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI78</accession>
    <name>W4TI78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aromatic amino acid transport protein AroP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67859">
        <property type="protein sequence ID" value="GAE67859"/>
        <property type="gene ID" value="JCM18909_950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="38" mass="4323" checksum="88D5AB7735F8AD8D" modified="2014-03-19" version="1">MVVVMTTMPPYRIAVAIGPIWLAVLGLGWRLSRRRQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF3</accession>
    <name>W4TIF3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68213">
        <property type="protein sequence ID" value="GAE68213"/>
        <property type="gene ID" value="JCM18909_1335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="303" mass="32771" checksum="C4C57C4E51B7D3E3" modified="2014-03-19" version="1">MDDHTLCAARDPQGIRPLVLGRLSSGWVVASETAAIDIVGGTFVREIEPGEMVAIDAAGLRTSRFAAARPKGCIFEYVYLARPDTVIAGRRIHNVRVKVGKILARESPADADLVIPVPESGTPAAIGYADESDIPYGMGLVKNPYVGRTFIQPSQTLRNLGIRLKLNPLRDVIEGRRIVVVDDSIVRGNTQRQLVRMLREAGAAEVHVRISSPPVQWPCFYGIDFATRAQLIAPGLDVEDICRSIGADSLGYVSLDGLVRATHVDADNLCRACFDGVYPVPVPVSARAVLADATHTDPNQEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ1</accession>
    <name>W4TIJ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68785">
        <property type="protein sequence ID" value="GAE68785"/>
        <property type="gene ID" value="JCM18909_1946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7223" checksum="2D2E34792D9AE3E8" modified="2014-03-19" version="1">MRRADRIGREVILVMIRLKVLGVVRLYLWGVDGMTIDEMNEPFICHKRDLKPKRVAGLLCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIM6</accession>
    <name>W4TIM6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68815">
        <property type="protein sequence ID" value="GAE68815"/>
        <property type="gene ID" value="JCM18909_1979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9171" checksum="FFFD02D23CAB1B8E" modified="2014-03-19" version="1">MTQRLQDFHAQCDPDDLENTNRLLPSRRSVWLGQLTVTPGICLIGSTRGAMRMERQSTISLATTSPSAITVLSSIRTLPWSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ59</accession>
    <name>W4TJ59_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68433">
        <property type="protein sequence ID" value="GAE68433"/>
        <property type="gene ID" value="JCM18909_1571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="332" mass="36061" checksum="B526AA7DA43586DA" modified="2014-03-19" version="1">MKRADDPRAAARESIDVAPHPPTDGASIDLVVGGFLQAMASARDDYRVARSYLTRDMTDRWDPHAKVTIYDATNHKPTSTVATAALQAPVVGQIDSGGHYHPTSSQTLNHDFGMAQESGQWRISRPPEGVLISQYTFQRSWSTIPIYFFDSGGGPPRARRHSSSQRRRRPRCRSSGDDSRGSRASRCGAADGLAGRGDGHGDDVGGCRRRGHRSVECFGGPTVAIPAASASQPGHMDLNGFAAISRIRFTAGGSLLSLPEAAQDQTVSADLYAEFIPLPTTHSPTVVAVVRGRWGVLWPQDTTSRSCPEHWGEGRPRTTVWRRSHLPSLRCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ87</accession>
    <name>W4TJ87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68851">
        <property type="protein sequence ID" value="GAE68851"/>
        <property type="gene ID" value="JCM18909_2016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="10945" checksum="E1FBF13B139D263B" modified="2014-03-19" version="1">MRSTASILHLDMDAFFASVEQRDKPSLVGKAVIVGGVGGRGVVATASYEARKFGVHSAMAGSQARRLAPNAAFFCPDGLRLTGSPRRLSWRRCGSSRRLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ97</accession>
    <name>W4TJ97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-ornithine 4,5-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68478">
        <property type="protein sequence ID" value="GAE68478"/>
        <property type="gene ID" value="JCM18909_1619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037086">
        <property type="entry name" value="Lys-AminoMut_asu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09043">
        <property type="entry name" value="Lys-AminoMut_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lys-AminoMut_A" evidence="2">
        <location>
            <begin position="36"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="311" mass="33769" checksum="55C706F0D319F0F4" modified="2014-03-19" version="1">MMAGAQIFQIDGAHNANATARHGWKVMPELMVQHGLNCMYSVLVGMPKDLIGLSTVPPSTPPAPKLWYDLPYAVALRDLFSEYKMRAQQNTRYIESDLAEAIRTHTIDTLISMLTSADIQSTITPDEGRNLPWHHNSVRGVQTVKQTWAALDGIKEMVTINREGPLGHMVRDLKERAIGFLTEMLHVGGYFVAVENGFFVDSADSRSATTTASPATAKAESPREPSSSVTPTISPQSATISATTTCPRVLTSRATSSTAAPCANPRKSSTSMSSTPTTRPRPAWPAPARSATAQRYGPRLNGPVTVSSWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE6</accession>
    <name>W4TJE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68274">
        <property type="protein sequence ID" value="GAE68274"/>
        <property type="gene ID" value="JCM18909_1398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="5">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7307" checksum="CF042F6B5B199163" modified="2014-03-19" version="1">MDIADNIGGRSFCALADGAVGCLRGAIGHFRDEFEAGCRGIPAWQYLPYERSSIFNDADRRVLEGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH5</accession>
    <name>W4TJH5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68573">
        <property type="protein sequence ID" value="GAE68573"/>
        <property type="gene ID" value="JCM18909_1720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="14129" checksum="520F97242EED2F2B" modified="2014-03-19" version="1">MARRGSFFDGWNEYFSYDRWVACCERELEPLGVSLDWFTTRERDYEEVLPWDHLDSGLDRDWLWDDWQDALDGEAVNDCRWNPCYDCGVCPQMGTEIQVGPSGHPLIPLTPVVPDLAPSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL2</accession>
    <name>W4TJL2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="7" type="ORF">JCM18909_2334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TJL2"/>
    <dbReference type="EnsemblBacteria" id="GAE69145">
        <property type="protein sequence ID" value="GAE69145"/>
        <property type="gene ID" value="JCM18909_2334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6917" checksum="85258E413EE1E2B6" modified="2014-03-19" version="1">MSKLKITQIKSGIATKPNHRETLRSLGLKRIGDTVIKEDRPEFRGMVRTVRHLVTMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM0</accession>
    <name>W4TJM0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68623">
        <property type="protein sequence ID" value="GAE68623"/>
        <property type="gene ID" value="JCM18909_1771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007331">
        <property type="entry name" value="Htaa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04213">
        <property type="entry name" value="HtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HtaA" evidence="2">
        <location>
            <begin position="124"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="351" mass="36538" checksum="0F66E38E4A651F0D" modified="2014-03-19" version="1">MNNDGSFTITMKAPTFEQGKDFVVLTTKAHGVGKTDHSDDTRTPVTYREATPAPTGPTTPVAPSKQPSKQAAPSKQAKPSKQAGPNKQSTTTQKKTAGHRSQTPAAHRTMTKQVCTIGASKVTSGSLTWGIRTSFTSYLRGPIANGSWKLSGGANWNGSAFTFPLTSGSFDPATKSGSLKYSGSVHMTGHHGILDMTLAEPSLQIKGSTGHLYLDVKSSSMDGKKTNYGRVDFATFRVSVSGNTAIQGSPVKLTATGTKAFAGFYRAGEPMNPLSTNLTLSAEKVCHNVTVDAVTGKVIGDDSGKAAGRGLPVTGAEGPSSDDIDLGIVGGLALTVVVSTVVVCRRYAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS8</accession>
    <name>W4TJS8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dicarboxylate carrier MatC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68787">
        <property type="protein sequence ID" value="GAE68787"/>
        <property type="gene ID" value="JCM18909_1949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009827">
        <property type="entry name" value="MatC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07158">
        <property type="entry name" value="MatC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="MatC_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="MatC_N" evidence="2">
        <location>
            <begin position="165"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="341" mass="36315" checksum="0DD2F89E780BFBC1" modified="2014-03-19" version="1">MIFLVSVLISALGAGYYAVMVLMAPIALLVCRKIGINPLVGALCADCGGQVGSNFMVGLNGVIFRNLITGEKFSSNEAFVVSTTIFVVYLVMTFLIILTMLFISSHQRKRDGMTAQEVTFAEPIPLDRRQRTNVWLIGVFVVILLVPPILHLCMPHNSAVTWVNSRVDVSLFAILFAVVCAFMRVGEEKESLLHVPWSTLIMIGGMGMLVSIAVKAGTISLLAGWVGHTPRLLIPVVLCFLAAVLNMFGGSFVGVVAPALFPVVATLARATGMSPVLLYTSTTIGGLATGISPFSAGGAMVLGFTDKDERDDMFHREFAVGLPVCVGAALVVSFLCSLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW0</accession>
    <name>W4TJW0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bact-PGI_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68822">
        <property type="protein sequence ID" value="GAE68822"/>
        <property type="gene ID" value="JCM18909_1986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bact-PGI_C" evidence="2">
        <location>
            <begin position="189"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="339" mass="36223" checksum="CB5933A70D9B9215" modified="2014-03-19" version="1">MTFDDSRLDAPLDALAERVLRQLACTGARIRRDSADLDEVRRTVGEWGQPRGVLVVGPEARLVRSVLEPICPVPLVAWPFLRLPAWVGPLDLVVALDSDGRCAAQVAEARRRGSAIILASTGETESWQAAGSHGTARIQMASEDAMSAAVAALSVLSDLGLGPVVDPGQVARVADMVAESASPHHDLAVNEAKDLACALADAEPLLWGGSVLAARASRRLAQWMRRATGRIALSADSAALRPVIDSAPRRDPFADPDLDGEMRRPVLVVMDDAETEHAAVRRDLEQLCAAHDVTVRSVTLPLGIDEQSSPMSRYVALLLQGSFAAVYVALGLDRLKEMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX5</accession>
    <name>W4TJX5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68733">
        <property type="protein sequence ID" value="GAE68733"/>
        <property type="gene ID" value="JCM18909_1887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="29487" checksum="A8227A9B1E7F8BDA" modified="2014-03-19" version="1">MASHSEIMTVVLNQVDHLDEEQRKKNCLRDLRRLLDSEGLGKAKMMAISATTGEGVDDMRVALARAVRAKKAQAARLHADLDNVSQRLAEATGDAAGQVSQDSVDQLIAALCIAGGVEPVVEATRDAYRRRGHRATGWPVTAWVSRLRPDPLHRLHLDLGSTRKKGRARSTEPTDVQRSAVTARVGVAGAKIDTAVRSLASEASEGLPRSWADAVRAASLSHRTDLPDDIDRAVASTDLGVHHGTGWWKLVTVVQWILMIIVVAGLAWLAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK16</accession>
    <name>W4TK16_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ORF">JCM18909_2330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TK16"/>
    <dbReference type="EnsemblBacteria" id="GAE69141">
        <property type="protein sequence ID" value="GAE69141"/>
        <property type="gene ID" value="JCM18909_2330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14656" checksum="DBD4B66EA7288562" modified="2014-03-19" version="1">MTMTDPIADMLTRLRNANQAYHDQTSMPHSKIKAGIAGILKSEGYIADYKVNEPKEGEVGKTLTLTLKYGENRERSIAGVRRISKPGLRVYAKSTALPKVLGGLGIAIISTSQGLLTDKQAHEKSVGGEVLAYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK18</accession>
    <name>W4TK18_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exodeoxyribonuclease V alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68464">
        <property type="protein sequence ID" value="GAE68464"/>
        <property type="gene ID" value="JCM18909_1603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD_C_2" evidence="1">
        <location>
            <begin position="172"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="247" mass="26564" checksum="1825F37A6133BB35" modified="2014-03-19" version="1">MDVLATAAGVTHDSPSPDSIATISGRRSITWIDADPANITMADLPEVAKVIARTGARMLELAQASADAAALKLVDAHRLLCAHREGPYGVDEWSQRMVTVLSDVLPGVGQGRWVLGETAIVTHNLAQLGVNNGDCGVIVETRPVPTIALPGPGGVPRRLPCSLIPSLQPLQAMTIHKAQGSQFTDVTVVLPPPDSPLLSRELLYTAITRAREHLTVVGTRESVERAIDRDNDRRSGIQRRWEESRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA2</accession>
    <name>W4TKA2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68574">
        <property type="protein sequence ID" value="GAE68574"/>
        <property type="gene ID" value="JCM18909_1721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="260"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="498" mass="55119" checksum="9CCCE3195A7EDC43" modified="2014-03-19" version="1">MNTQDLLGRIEPLLSRVNKPIQYVGGEHNSIVKEWQDADVRWVLMYPDAYEVGQPNQGVAILYEVLNECDWILAERTYSVWPDMEKHMRAAGIPQFTLDGHRPVRDFDIMSVSLSTELGYTNMLNAIDLAGIPVRQADRTDTDPIVLIGGHAAFNPEPVADFIDAAVLGDGEEACLEISEIIRDWKKEGCPGGREDLLVRLATTGGIYVPSFYDVEYLDDGTIGKVAPNRLEAPYTVSKHTVMDLDEWQYPKRPIVPVAETVHERYSVEIFRGCTRGCRFCQAGMITRPVRERSIDAIAQMVDGGLQATGLEEVGLLSLSSADHSEISDITKGLADRYEGTNVSLSLPSTRVDTFNIDLANELSRNGRRSGLTFAPEGGSERMRRVINKQVTEEDLIRTVATAFGNGWRQVKLYFMCGLPTETDEDVLGIHDMASHVIAAGRAAAGRKDIRCTISIGGFVPKPHTPFQWLLKSLLTRLIIVCRCCAIPSAPIVSLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB2</accession>
    <name>W4TKB2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gal_mutarotas_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69385">
        <property type="protein sequence ID" value="GAE69385"/>
        <property type="gene ID" value="JCM18909_2594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040633">
        <property type="entry name" value="Gal_mutarotas_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18080">
        <property type="entry name" value="Gal_mutarotas_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_3" evidence="2">
        <location>
            <begin position="123"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="382" mass="39707" checksum="ABB9B6431ED07E24" modified="2014-03-19" version="1">MNLGKVEITPRSSSNGSGRIHDYELYTADTKTCNNAAFSSAKPVATGSYGVSDTSIRKITFAATKATCVKVKVNSSWGGDGSDEEVSSMAKFNAFTVDGSDPSPDPTPSEPPTPEVPKDAISLSDGTVTVRVRHDFPQVIDYTVDHAHMAGRIGSPLTKVRINGTDHVATVSAPTTTGSSASWKLTFRDLPGVELTADIKVSDGVMTWSIPHIVDTPDHRVNTVSVPGLTLASVTSTDPKAQLSSANIVVDRNKTGDLFQPLATTDASQDTSWVAMANDSTLAAGFEDNATQDGLVGSAATVARFVHSISQIGGTKVGAIEPATWVHRGKGSATPCPTDSLGNKAICQLPGGATVKDGIGPDPDTPYVRVKIVADANADGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE7</accession>
    <name>W4TKE7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type multidrug transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69405">
        <property type="protein sequence ID" value="GAE69405"/>
        <property type="gene ID" value="JCM18909_2614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="228" mass="24141" checksum="770609A5692493A5" modified="2014-03-19" version="1">MRVTFGHVIALDGLSLTAATGAITAVLGPNGAGKTTMMRCCTSLISPDSGRIDVLGHAPGSPEAAAATGLMPQSAGAWSGIRAGELLHYMAGLHANPIDPDLLIEALAITPFARTTYRRLSGGQQQAVNLAAALVGRPKLVFLDEPTSGMDPHARHHTWDIVEHMRHDGVSVVLTTHNMDEAQRLADHVWIVDRGRVATHGTVPELTAESSLEDVFLTHTSDRAAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF3</accession>
    <name>W4TKF3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68639">
        <property type="protein sequence ID" value="GAE68639"/>
        <property type="gene ID" value="JCM18909_1789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="356" mass="37901" checksum="0B25212D35EE1435" modified="2014-03-19" version="1">MLSVGIDIGGTKVAAGVVDESGQIVRRIQRLTPSRSPEAVEDAIVESVRELARSLPICAVGIGAAGWIDTEQALVRFSPHLAWRNEPLRDRLSERITVPVLVDNDANAAAWAEFRFGAGQGSRVMVCLTLGTGIGGALVINGRMFRGRYGMAGEFGHMTVVPDGHWCPCGNRGCWEQYASGNSLVRDARALLAEGAPGAQDLLGHVADRNPDNLIGPDVTRAAVDGDRLAIELIADIGIWLGRGMANLAAALDPDLFVIGGGVSAAGDLLLEPARTVYARTLTGRGFRPMADIQKAHFGNDAGLIGAADLARHSISEPPGMARGFWPRRRTAVRKPRRTLRQSLSETLAGPVVRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP7</accession>
    <name>W4TKP7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69520">
        <property type="protein sequence ID" value="GAE69520"/>
        <property type="gene ID" value="JCM18909_2745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="5">
        <location>
            <begin position="119"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="23613" checksum="86B53DA8311D1A51" modified="2014-03-19" version="1">MLGLLANPDRLTWGSVGVGIAAGLLLTLVARPVAVAACTIWFGFKRNERLFMSWAGLRGAVPIILATIPMASHMDRADEFFDVILVLVVVFTCIQAPTLPAAADILGVVDPQMAKDVSIEVAPLDEIAADLLQADVPTGSRLAGVTIRELRLPRNCVVSLIIRGDRSFTPHAGTVLEQGDELLIVVPQGKRRTAAERLIEISRGGRLARWHGLRVRNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT2</accession>
    <name>W4TKT2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">JCM18909_2326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69137">
        <property type="protein sequence ID" value="GAE69137"/>
        <property type="gene ID" value="JCM18909_2326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12793" checksum="04366C4D96C84E47" modified="2014-03-19" version="1">MIQQETRLKVADNTGAKELLCIRVLGGSKRRYAYLGDTIVCTVKDAIPGGNVKKGEVVKAVVVRTVKSHRRPDGPTSSSTRTLPSSLRETGSLVVPVSSAPSPASCVRRSSCASSRSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL09</accession>
    <name>W4TL09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69655">
        <property type="protein sequence ID" value="GAE69655"/>
        <property type="gene ID" value="JCM18909_2900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13062" checksum="28DE640791BD54FB" modified="2014-03-19" version="1">MRVPALLGVIAIGLLLSRVARRVGRDPHFAAWFSTLNPILVVDFIGGAHNDALMMGLVVIGLWIACMTSWSWTIGAVLVGGAAAVKQPAFMVAVALPLIRHPMVSWHPRHLFFRLWGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL34</accession>
    <name>W4TL34_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69680">
        <property type="protein sequence ID" value="GAE69680"/>
        <property type="gene ID" value="JCM18909_2925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="10867" checksum="2ECBA18534873319" modified="2014-03-19" version="1">MGHGAYGAAWALQELLTIKSDDVPGRVKVYEAIVKGENIPEPGIPESFKVLVKEMKSLCLNVEVLNSEGQEIDLRGSEEDTRSGLGIDIGRRPGADNAMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL51</accession>
    <name>W4TL51_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PreQ0 transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69456">
        <property type="protein sequence ID" value="GAE69456"/>
        <property type="gene ID" value="JCM18909_2672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18571" checksum="45D790E63796D122" modified="2014-03-19" version="1">METSCGHGRHLDDMRQHGYHFAVTSHSTSLRSSAATRPAYADRGSGHYDILLTLMCVVVILSNIGGSKGVQLGPITTDGGFFLFPLAYVMGDITTEIYGIKAARRAIVMGFICAILSVLCFWAIITLPGFTDPYSVAHDTALEMALGPLCRWCSPEHADFWLDSLRTRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL84</accession>
    <name>W4TL84_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Electron transfer flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69292">
        <property type="protein sequence ID" value="GAE69292"/>
        <property type="gene ID" value="JCM18909_2492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="8885" checksum="7D2EA2EACCFBB241" modified="2014-03-19" version="1">MTIAVAYKVAANPQDARVEPDGRIDWSRGKLGISDYDPVAIQIAREAADVSGTELVGVSVGTVAATAAKEKKKMSWLVVWIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL99</accession>
    <name>W4TL99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68919">
        <property type="protein sequence ID" value="GAE68919"/>
        <property type="gene ID" value="JCM18909_2093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6797" checksum="65BF87D50B4F6DEA" modified="2014-03-19" version="1">MQNVQDRVVAWLVEHSGIEVRDTALSPETREWLKSIDRLPIEKQASIIEHDRARLRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE6</accession>
    <name>W4TLE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68974">
        <property type="protein sequence ID" value="GAE68974"/>
        <property type="gene ID" value="JCM18909_2152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS_IIB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13421" checksum="25DC9D339A8A2C05" modified="2014-03-19" version="1">MVNKKVLVCCGTGIATSVQVANKLQRMLRDRGVTATMKECKTANVSAQMTTFQPDAIVVTTAITPPDEEVKVYRARHCSPVWAPKNSQTRSLATSKPNRSLAVIAAGGIAKRLRRLPHGRKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI4</accession>
    <name>W4TLI4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69606">
        <property type="protein sequence ID" value="GAE69606"/>
        <property type="gene ID" value="JCM18909_2843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5443" checksum="0C69CDCBEA60EEDE" modified="2014-03-19" version="1">MPAQGGPASSNSYPEHGNITDDPNVTHMVDNELNPTHAHTIRCTPMPFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK3</accession>
    <name>W4TLK3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ORF">JCM18909_2601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69392">
        <property type="protein sequence ID" value="GAE69392"/>
        <property type="gene ID" value="JCM18909_2601"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="5"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27126" checksum="6B7CB0069B65B64C" modified="2014-03-19" version="1">MRYQSAQGLAEGVSHRLVQTIVRIQAAQERIDLCLTGGRIANIVYAAMEDVPECANIRPDQLHVWWGDDRFVPTGHPDRNSLQALSLLSSAIRLDPSKTHVMPAADGKADPDEAAYSYAQELGGVVFDICLLGMGTDGHVASLFPGHPSFNPTTAALAVGVTDAPKPPPDRLSVTMPVINRSKRVWFLVSGSEKKLRLSRRFLLETSPCRLPGPTALSRRVGWSTMTPRSVYRGTTARCDAAVTTASPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM4</accession>
    <name>W4TLM4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69885">
        <property type="protein sequence ID" value="GAE69885"/>
        <property type="gene ID" value="JCM18909_3150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="7799" checksum="42A640FFC3F23987" modified="2014-03-19" version="1">MSSDTPGRVALVTGGSRGIGAAIAADLYAQGYRVAATSRSATAPEGVLPIACDVTDATRLTRLSARSSKNLARSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLQ3</accession>
    <name>W4TLQ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-ribazole-5-phosphate synthase CblS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69358">
        <property type="protein sequence ID" value="GAE69358"/>
        <property type="gene ID" value="JCM18909_2566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="246" mass="25896" checksum="829F3AF95E3872BE" modified="2014-03-19" version="1">MSVTRLRDLLLADIPASRLVIACDTIGGIGPRPDDSYPADPVWCAHLGARVPLLEVLCAGARPLVLVDTLCQDSASAQPMIAEFRRCALDAGIDPDAVTGSTEDNVVTTQTGIGVTIIGVMHHEDLPKSLDGDVLVCVGAPISAPDDDVIPGRREIVDVTEVRALMASGKVHDCVPVGSHGVAWEATQLASTAGLRVAFQRTDVDLPHSGGPATCIVMACDKTNLEQLHALVNPERPWAVIGHLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT3</accession>
    <name>W4TLT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69711">
        <property type="protein sequence ID" value="GAE69711"/>
        <property type="gene ID" value="JCM18909_2960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="3">
        <location>
            <begin position="31"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="234" mass="26322" checksum="C63C7676441BE06D" modified="2014-03-19" version="1">MTITDQLKRVYAQYSAQPDDLAKYLYLNHMHDRNEVLYFRLLAEHIEEMLPIVYTPTIGKAIEEYSHWYDRPRGIYLSIDDPEDMEQALAQLGHGPDDVDLIVATDAEGILGIGDQGVGGVAITVGKLAVYAAAAGIHPHRVLPVILDVGTDNMERLNDDGYLGVRHPRVRGERYDEFVQQYVETAHRMFPHALLHWRILRPATPPGFSTNTATTTARLMTTSRAPRPSSSRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU5</accession>
    <name>W4TLU5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">An allosteric effector of glucose-6-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69393">
        <property type="protein sequence ID" value="GAE69393"/>
        <property type="gene ID" value="JCM18909_2602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17348" checksum="479DBAB4E7387A81" modified="2014-03-19" version="1">MQSLIRRAAHLTEGDSDLCWARTTSWRALAAAALDQHPATVKSARVESAAGNAPAMLLAAWLGLRLGVSVERVTTDAPGISAIVMSTSGGDIEIRRRSGRYAVYRIPGEPARGVALDRREVQMLIGEELRRLGPDKVFTAVMAEIHDGAGRISLTNDRDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM30</accession>
    <name>W4TM30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69587">
        <property type="protein sequence ID" value="GAE69587"/>
        <property type="gene ID" value="JCM18909_2821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11527" checksum="465636590C87E847" modified="2014-03-19" version="1">MLSSSPSHSANGSQVVESSNMTAHPLAIIVGTFAVLALVQTIVCVETCEETRRIATSSHSDLSGGRVRVNDWTIDRRSIALLERSNKCFSHGGGQRGAQDNSMTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM97</accession>
    <name>W4TM97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69528">
        <property type="protein sequence ID" value="GAE69528"/>
        <property type="gene ID" value="JCM18909_2754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15250" checksum="162BCBEFC6E757CD" modified="2014-03-19" version="1">MVPILRAGLGMLEGMMRLIPSAEVGFVGMARDEETLQPMTYAERLPKDLSGRQCYVLDPMLATGGSLGGTVEFLVRRGADHITCLCILAAPEGIENFRKLVRDLDVPCHLIVAGLDDHLDEHGYIVPGLGDAGDRLYGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD3</accession>
    <name>W4TMD3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69876">
        <property type="protein sequence ID" value="GAE69876"/>
        <property type="gene ID" value="JCM18909_3141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17546" checksum="B22ACD700312DDCF" modified="2014-03-19" version="1">MSSANPRRTLPIDGFVLAIVVTAIIGSMLPATGSAVPVVKHGVTVLIFILFFLYGARLEPRETLDGLKNWTLQGAILATTFVIFPLIGLAMRALVPWALPGTLYVGMFVDLPRTVDGTVVDQFHLDCPRQRRRSYRRSHYVESLRDLPHAPLSPPPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG3</accession>
    <name>W4TMG3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69379">
        <property type="protein sequence ID" value="GAE69379"/>
        <property type="gene ID" value="JCM18909_2588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028204">
        <property type="entry name" value="Tricorn_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14684">
        <property type="entry name" value="Tricorn_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Tricorn_C1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11412" checksum="29B8E2F170482462" modified="2014-03-19" version="1">MASHYWREDMNGVDWDGVLNRYRPLVDLCHVVDDLHDILWETVAELNTSHSYVSASGAAGDSDMRAGSWEPTSAAGLTGLRSSGLFPASRRILARGHHYGRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI3</accession>
    <name>W4TMI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucosamine-6-phosphate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69752">
        <property type="protein sequence ID" value="GAE69752"/>
        <property type="gene ID" value="JCM18909_3003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="2">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="230" mass="24841" checksum="E4FA726CDB98CB86" modified="2014-03-19" version="1">MEVIICSDEQAVGRIAADRIAKVLGRAKAPVLGVATGSTPLTTYSSLAALAAEGKADFTDLRAFALDEYIGLPADDERSYAATIRHTVTEQLGLDPANVHTPDGMADDLDAACAAYETAIQEADGVDVQILGIGANGHIGFNEPPVRCLRALASRLSRSAQRLTTPASLRRGRRSRVTASPRGSVPSWTLAMLCCWPSEPIRLTRWQGLLRGLFRRCARRRCCSSTPMFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI4</accession>
    <name>W4TMI4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69633">
        <property type="protein sequence ID" value="GAE69633"/>
        <property type="gene ID" value="JCM18909_2873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848826" evidence="1">
        <location>
            <begin position="47"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18705" checksum="0C071A8630C7499C" modified="2014-03-19" version="1">MTSSFTGDAVVIVEVSQLCHIVRSMSFQRFLAGVAAILLLLPTACADDAQAPVVDNLGTVLSPSNSLIREPENSSVNGTLKSTYEYLRLIDGHDLPDDDGYAHDHLVAALRPYLVNGGDSRQAHVNQLMAASSLKTLNALSDKERSEVDKRTRLPKGCITRKTVMTDLPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK3</accession>
    <name>W4TMK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Biotin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70220">
        <property type="protein sequence ID" value="GAE70220"/>
        <property type="gene ID" value="JCM18909_3518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9153" checksum="F7510E18174ACEED" modified="2014-03-19" version="1">MLNLADMTERGLRGESITREEALEILRSSDDELMSIIAAAGKVRRHFFSITGFASTTWSTSSPACVPKTAPIARSVWDRVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMP5</accession>
    <name>W4TMP5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homoserine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69981">
        <property type="protein sequence ID" value="GAE69981"/>
        <property type="gene ID" value="JCM18909_3257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7597" checksum="55CF11FE765974CF" modified="2014-03-19" version="1">MMNTTDSASAQPIRVALLGCGVVGSQVARMIESRTEDIAARVGRQVELAGIAVTHPDRPRQGLDSRLFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT4</accession>
    <name>W4TMT4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-aminohexanoate-dimer hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69852">
        <property type="protein sequence ID" value="GAE69852"/>
        <property type="gene ID" value="JCM18909_3111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="280" mass="30246" checksum="5F4E0056C0A06D79" modified="2014-03-19" version="1">MEAMTDSVLDVTADAFEQAGAHPHRLVVRQHGQVVGRRRWAPWSPDVPSLVYSCSKTFTSAAVGIAVNRGAFGYDDILADLWPQACTASTGPVAKSMTVRNALSMSTGHSPEQLLEPTLVSRRLPDLNTARILLATEPEGRPGIDFAYNNLATWMLSRLVAQHTGEDVDTIITKEVLDRSGRGHTPGSVTPTASRWGSQDCILTPKTSLCSASFSSTMGCMRRPSTTRGVDQAAPCPSSHLRQRDRSGMGNGVWLADMDVKPWVPSGRGLRPVCPHRSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN05</accession>
    <name>W4TN05_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70106">
        <property type="protein sequence ID" value="GAE70106"/>
        <property type="gene ID" value="JCM18909_3397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DeoRC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10272" checksum="7C557473C7A85595" modified="2014-03-19" version="1">MRFDTAVIGTCAANPDAGLTVAGWGDAQVKRAAIASAQRVFLVATADKFNHTAAHRFASIADLDAIITTYGAPPSAIAEARIAGVTMIELDHSGSTETLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN08</accession>
    <name>W4TN08_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myo-inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69584">
        <property type="protein sequence ID" value="GAE69584"/>
        <property type="gene ID" value="JCM18909_2818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="1">
        <location>
            <begin position="12"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23499" checksum="9BBBEDDB84F5828C" modified="2014-03-19" version="1">MRRFDVGYGQMKDVLESGDLGQPTLVHCRHRNPSVPAKIYTTRNMIDDTAIHEIDTCRFLLDEEMMSVRVDTPRRSSLAPEGLQDPLVMVAKSAAGVLVDVEVNVNIQFGYSIECELVMESGAVRLGDQEKSVIRDGNGNRNAICRSHIDRFHDAFNAEVQSWIRAVEEGQHTGSSAWDGYAATCVVDAAVASLEDGGQEVAVDMIEKPDLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN42</accession>
    <name>W4TN42_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69833">
        <property type="protein sequence ID" value="GAE69833"/>
        <property type="gene ID" value="JCM18909_3089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07208">
        <property type="entry name" value="Pat_hypo_Ecoli_yjju_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037483">
        <property type="entry name" value="YjjU-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22255" checksum="E4F95A47F902BA75" modified="2014-03-19" version="1">MTTSIDGTALVLEGGGMRAAYTSAVIVKMLGLGWKFPHVSGISAGSSLTANYISRDPERTRLSFTDFAANPRFGNLGTWLAGRGYFDGEYIYQRTAEPHQALPFDFLTFCASGQAFRIGATRTSDRGQEWFTREDMKTMDDLMVRIRASSTMPGFMPPVTIKGVEYVDGALGDTGGIPIDGAQLDGYDRFFVVCTRPRGYVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB6</accession>
    <name>W4TNB6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70231">
        <property type="protein sequence ID" value="GAE70231"/>
        <property type="gene ID" value="JCM18909_3529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="15309" checksum="15608AD1F3A4A62F" modified="2014-03-19" version="1">MGDADPRARAVLATCLTDDPEVYRQSYLEAVSTLCAGVRLFMPVMADEEGEIGAVKFTNKLGNTALLAFTGIDSLTAWDSRARPVPGRLPDLAATVTEVAADALLIDVAGPAPLVIGTDVLKPIEDGGRLVKLDDGWGWVRSGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNC7</accession>
    <name>W4TNC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70455">
        <property type="protein sequence ID" value="GAE70455"/>
        <property type="gene ID" value="JCM18909_3782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="70"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="257" mass="27980" checksum="75A93D10D9C7FDE1" modified="2014-03-19" version="1">MVRKTRASDRAYCRDGDAIFSLVGCGSAVTDPSISKASTATLPVKQGHTSYPLTVTSCGVSQVFESAPKRAVTLTSTATETMLELGLEKRMVGTAYQRNRSIGSRYKKAYDSIPILASGQPSMEKLLSVNPDFVYSGYPDGFSKSNGHTREDLKRLGIKTHLSPVGCSDQVKTFEDETKEIRTIGQIFDVNDKAEKAVRRFNSKVSSVKNSVKGKDRPKVFLYNSGIEAPITVGGWAYASVMIDAAGGENIFFAHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP0</accession>
    <name>W4TNP0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70580">
        <property type="protein sequence ID" value="GAE70580"/>
        <property type="gene ID" value="JCM18909_3930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18548" checksum="C0D92820A0BB02F8" modified="2014-03-19" version="1">MRLYRAVLADTDIQITVRIWNTTDRDWTWAPLDTWAPDPAPTTPAQLADELHRHGWITPEVPTTLTEVAVIPENWQAFVEHALAVRNQQADQLRVAENVLTDILGDAVDAGLSVTAIARSIGMSRVAVYKRGVKTINSMRQAAQTSRPFVSSQLTQAEKTALGLYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR5</accession>
    <name>W4TNR5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70605">
        <property type="protein sequence ID" value="GAE70605"/>
        <property type="gene ID" value="JCM18909_3956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6576" checksum="8C78A8EC98B70B47" modified="2014-03-19" version="1">MALVLIALCVQWFISDRRDQRRVDASEDAGLDESLAAYNDMLARMAGQEIKPHDPGTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNS0</accession>
    <name>W4TNS0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70610">
        <property type="protein sequence ID" value="GAE70610"/>
        <property type="gene ID" value="JCM18909_3962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010860">
        <property type="entry name" value="CAMP_factor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07373">
        <property type="entry name" value="CAMP_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849166" evidence="2">
        <location>
            <begin position="29"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="257" mass="27438" checksum="A6DB9E5135A3237D" modified="2014-03-19" version="1">MKKTHLVTPLLIGAMLVPATLSAPSAHAVEPTTTISTTATHELSASDAHNSLQLLNARIATLQSVQKSVPGSDYSDQIRDLLKAAFDLRGLIDTLAHGGIPFYDPSTIMPRIKLAATTIDTIHTATTTLQNKVRPAHVELGLEVTKAVLLTANPASTAKELDAEAPPSRLAWTRSRSTPTSPRMTLPLCTYAPTSVGPSGRCALTVTGTSLVTRAPKCTRRSITPSPSRRRSTEPKDDRREHPGCTHQASCGLSDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNS6</accession>
    <name>W4TNS6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70192">
        <property type="protein sequence ID" value="GAE70192"/>
        <property type="gene ID" value="JCM18909_3490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="248" mass="26456" checksum="49BC8CC01EB2919D" modified="2014-03-19" version="1">MCGRCRALHRLDVDPRQRCHPARCLISMALINGWLALATVCIVPLLILLSVKGVAPVKRNTRRERRAEAAVAGSAADLTSGLRVVQGLSAQRRATARFRTASRQGLDATLRTRRVKGVYTGTINASVGVFITALTVLAGWLTLAGRISVGELVTVVGLAQTLGPPLRALGVDTATMLATAHAPGTDSVSCVIARQPGRSTPTTAPVPHPVMARWSCTSRSGMSSLTSPAAPMWVSWRLNRSVTPWPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV3</accession>
    <name>W4TNV3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PTS EIIA type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70083">
        <property type="protein sequence ID" value="GAE70083"/>
        <property type="gene ID" value="JCM18909_3369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6712" checksum="4BD1ABBB46AE37AB" modified="2014-03-19" version="1">MSLVLLLAINEGDYDDFVRFYQPLISVLYDRELVTELRSMSSYHEFMKFLDKQISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW0</accession>
    <name>W4TNW0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylosuccinate synthetase</fullName>
            <shortName evidence="8">AMPSase</shortName>
            <shortName evidence="8">AdSS</shortName>
            <ecNumber evidence="8 10">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purA</name>
        <name evidence="11" type="ORF">JCM18909_3719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="8 10"/>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70401">
        <property type="protein sequence ID" value="GAE70401"/>
        <property type="gene ID" value="JCM18909_3719"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="16"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE70401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24553" checksum="44DADF78323BBCA3" modified="2014-03-19" version="1">MEEHMPGIVVMGTQWGDEGKGKATDLMSERVDYCVRYSGGNNAGHTVVVGDEKFFMHLLPSGVLNPNSTAVLGNGVVLNLDVLADEIDALRGRGVDIPHPLISANAHLITPYHQTLDKVTERFLGSRRIGTTGRGIGPTYSDKINRMGIRVQDLFDESILRQKVEASLDQKNQILVKIYNRRAIDPDEVADGLLAHAERIRPYVVDVARVLNKGLDEGKVVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ4</accession>
    <name>W4TNZ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Twin-arginine translocation protein TatC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69909">
        <property type="protein sequence ID" value="GAE69909"/>
        <property type="gene ID" value="JCM18909_3176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13789" checksum="3853C3ACA1D9353E" modified="2014-03-19" version="1">MLNFTPHGMGITNLLDMNAFLALEIRVILLFGVSFLLPVVLVLLNLIHVLSSAQLKAARKWSIFGFFCLGAFVNPSGDPISMCALAIPLSVMYVIAEWICRSNERKRSTNNMGIDKSEFDIQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ9</accession>
    <name>W4TNZ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70267">
        <property type="protein sequence ID" value="GAE70267"/>
        <property type="gene ID" value="JCM18909_3571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17247" checksum="3CB3715BF3974187" modified="2014-03-19" version="1">MSMHILVVDDDRAVRESLARSLQYSGYEVDSAADGVEALAHLSGTHPDAVIMDVMMPRLDGLEATRMLRSNGNDVPILVLTARDAVDDRVDGLDAGADDYMVKPFALDELLARLRALTRRSRPEPEQDEAPEQLSFADLTLDPSTREITRGNRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP23</accession>
    <name>W4TP23_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="3">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome aa3 subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JCM18909_3459</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70163">
        <property type="protein sequence ID" value="GAE70163"/>
        <property type="gene ID" value="JCM18909_3459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="16">
        <location>
            <begin position="146"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GAE70163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="302" mass="33300" checksum="86E17A6FBBC1D30D" modified="2014-03-19" version="1">MGRRVSWRHDLDRNVPRSGRRAAGKVGGVCAAAVAVVALSGCGSTGPGRAARLGLVDPASDRAVHMGNMWIGAWVAALVIGVFVWGLIGFAAFKFRRKDGDPAIPRQSRYHLPLEVLYTIVPFLVIGVLFFYTVRTENKVLDKNPDPQHVVNVVGQKWSWTFNYMEANNPDAGGVVTHEVGTIEKIPDLYLPVNQSVRFRFKSADVIHSFWVPAFYFKMDVIPGHPNQFDLTPTKIGVYDGKCAELCGTYHANMIFKVHVVSVEDYNKHLQQLKAQGDTGEIKPANSVAALTTTDSHEGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP68</accession>
    <name>W4TP68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69989">
        <property type="protein sequence ID" value="GAE69989"/>
        <property type="gene ID" value="JCM18909_3265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046086">
        <property type="entry name" value="DUF6104"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19599">
        <property type="entry name" value="DUF6104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7517" checksum="2BFBBB586E74339B" modified="2014-03-19" version="1">MHDGAMYFTDRGIEELEDRRGDEEITFTWLADELRHFVDLNPEFEVPVERLATFLARLDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPI1</accession>
    <name>W4TPI1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobQ</name>
        <name evidence="6" type="ORF">JCM18909_3637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70323">
        <property type="protein sequence ID" value="GAE70323"/>
        <property type="gene ID" value="JCM18909_3637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="183"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="412" mass="44509" checksum="B4B8B8A79EE3A5FE" modified="2014-03-19" version="1">MNPVLLKPGTDRRSFVVLRGKPGGVLETGEYTTGRRHLAEAAWAAYDELAASHDMVICEGAGSPAEINLRRGDYTNMGLARAKNLPVVLVGDIDRGGVLASLFGTWALLDDDDRALLAGYIVNKFRGDDAILAPGLEEITDRTGMPSFGVLPWVPGVWLDGEDALEVGRWRHEGDAVDPSSLRVAVVRFPRISNATDVDAMAGETGVDVQVTTNPDTCQAADVLVLPGSRSTVSDLEWLRRSGIADVVARRAEQGRTVVGICGGYQMLCRTILDPDGQETTPGSVVGGLGLLPVEVDFAATKTLALSHGTWRGIEVGGYEIHHGVCRSLEDAEAFLDGVHVGPVWGTMWHGAFEHDEFRRTWLADAARHAGSSWRPHADELGYQARREAMIETLADALEAHVDVDRILHLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPN1</accession>
    <name>W4TPN1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000067">
        <property type="protein sequence ID" value="GAE70696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70696">
        <property type="protein sequence ID" value="GAE70696"/>
        <property type="gene ID" value="JCM18909_4074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="5050" checksum="5E5EFE8926C78EA8" modified="2014-03-19" version="1">MRHLGRIPLSVASSKVNDMSETTQPILMVLDGHSMAFRAFFTPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPY6</accession>
    <name>W4TPY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70294">
        <property type="protein sequence ID" value="GAE70294"/>
        <property type="gene ID" value="JCM18909_3602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6333" checksum="25E111E9B33188A6" modified="2014-03-19" version="1">MGGICNNQQVPRNPRVGVKDMLLSLAVILVPVMLIVWFFTRTLMSRISSRSTGNQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ63</accession>
    <name>W4TQ63_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70369">
        <property type="protein sequence ID" value="GAE70369"/>
        <property type="gene ID" value="JCM18909_3685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6330" checksum="BC925FD63903C2BC" modified="2014-03-19" version="1">MIDGNEAFAAAGVRERLDEIAYLYRWFVHGSSLESTRLEHHPSMSRLGHDIRHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ83</accession>
    <name>W4TQ83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mur ligase middle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_4082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000071">
        <property type="protein sequence ID" value="GAE70702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70702">
        <property type="protein sequence ID" value="GAE70702"/>
        <property type="gene ID" value="JCM18909_4082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12209" checksum="525CCA4D3B24A2E7" modified="2014-03-19" version="1">MPSSLPAMIGAMTSSPQRHRSSPQLQLALLAGRTAATVSRIAGKGSGASIRGRVTMKLAPRALPELLAGRRIASVTGTNGKTTTTHFLTAAVRAGTPDSQRSVVTNADGANLHHASSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQF5</accession>
    <name>W4TQF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70638">
        <property type="protein sequence ID" value="GAE70638"/>
        <property type="gene ID" value="JCM18909_3998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9331" checksum="7B7C55BC286D45AC" modified="2014-03-19" version="1">MSKNHKPTATDKASRYTGRMAASQGASVAETFQSAKTPITAFNVKLPTATHTALKMKAVADHTTMNDLLRKALEHTYGFPYDPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDL7</accession>
    <name>W4TDL7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endo-beta-N-acetylglucosaminidase H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_74</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67040">
        <property type="protein sequence ID" value="GAE67040"/>
        <property type="gene ID" value="JCM18909_74"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5462" checksum="04A017218FDC1090" modified="2014-03-19" version="1">METLRAAETQIRPLQRRGTKVLLSLLGNHEAPDSLTFQPGMTLTGSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDQ5</accession>
    <name>W4TDQ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinG family ATP-dependent helicase YoaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67085">
        <property type="protein sequence ID" value="GAE67085"/>
        <property type="gene ID" value="JCM18909_120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="1">
        <location>
            <begin position="234"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="329" mass="35608" checksum="374A564C3A195D44" modified="2014-03-19" version="1">MTTMAKRAMTWLDDDVGADLLNQADSMAHALEATTPGRVTTPDAQVIQTCAVLRDLARVAVSQLGRNDEDSSEPVDAERVQAQAAMREVFETAERMVGLAAADVVWVSESEKGYRSIHVAPLSVGGLLRENVFAQSTTILTSATLCIGGNFLAIARDVGLSPREQIEGDVPEVLETQMGWRGVDVGSPFDYSKQGILYAGRLLPRPGRDGIAPEVLDDLAELVWAAGGRTLGLFSSQRNAVAAAEHMRSAMPDIPVLCQGEGHLADLTRRFAADPRTCLFGTVSLWQGVDIPGDTCRLVVIDRIPFPRLMTRSWQPGVRLLRTLVAMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDR6</accession>
    <name>W4TDR6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67100">
        <property type="protein sequence ID" value="GAE67100"/>
        <property type="gene ID" value="JCM18909_137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042035">
        <property type="entry name" value="DEAH_win-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010222">
        <property type="entry name" value="RNA_helicase_HrpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01967">
        <property type="entry name" value="DEAH_box_HrpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="32"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="247"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="449" mass="49345" checksum="9E3F02FA54DA6074" modified="2014-03-19" version="1">MPNSLLEGELPGGGVVTFDTDLPIAAHADDIADLIKHHQVVVVAGETGSGKTTQLPKICLALGRRQIAHTQPRRIAARSVAERVAEEMGVELGEQVGYQVRFTRRATSDTALTVMTDGVLLAEISHDRDLCAHDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDTARFSAHFDDAPVIEVSGRTYPVEVRYRPLDPSEQIRPDDEDDIDDEDELLHRSSAPSLTSPDDEVVDQVTGICRAVQELCREESGDILVFLAGEQEIRETAEALADLNLSNTEILPLFARLSAAEQHRVFTPHTGRRIVLATNVAETSLTVPGIRYVIDPGTARISRYSVRTKVQRLPIEPVSQASANQRAGRCGRVAPGICIRLYSQTSFESRPEFTEPEILRTNLAAVILQMAQARLGAITDFPFVEAPDRSRINDGIRLLDELGALKPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDY6</accession>
    <name>W4TDY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66981">
        <property type="protein sequence ID" value="GAE66981"/>
        <property type="gene ID" value="JCM18909_10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer2_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE66981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12588" checksum="7AE1452C10BE795D" modified="2014-03-19" version="1">MRVELDIWRQNGPDAKGHFEHHIVEDAEPEWSLLELLDRLNDQIVENDGDPIVFESDCREGVCGCCGFMVNGKPHGPLPNTPACRQHLRAFPISPTSKLSHSARQPFRSSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE17</accession>
    <name>W4TE17_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_46</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67016">
        <property type="protein sequence ID" value="GAE67016"/>
        <property type="gene ID" value="JCM18909_46"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="347" mass="38185" checksum="77690A5327444CA7" modified="2014-03-19" version="1">MARPTFRDPQPPSVAQTLVSPPTGATLPLNQLAPEAALRRLELTIVRRLEGFLHGDHLGLLPGTGADVNDARPYEPGQDDVRMMDWAVTARTTVPHVRETIADRELEVWALLDVTGSMNWGTVSMTKRDLGIAAIATIGFLSQRMGDRFGGVIMRPDSVRRLPARSGRTALYGLLRSMLTEPIVADNAPGQVTLAKGIENLAASGRRRGMKVVVSDFLSPGDDVLDPSDRPEWERSLRRLSVRNQVLCIEVVDAAELDFPDVGDVMVRDPETSFARYVNTADKATRERMNAASRAQRERISAAIRRAGAGHLQLRTDSDWVTDIARFVLGYRRTAAILHQPPQGVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEZ1</accession>
    <name>W4TEZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67092">
        <property type="protein sequence ID" value="GAE67092"/>
        <property type="gene ID" value="JCM18909_128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013678">
        <property type="entry name" value="RNR_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08471">
        <property type="entry name" value="Ribonuc_red_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_2_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="1">
        <location>
            <begin position="152"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="302" mass="33471" checksum="34270798B254FC3A" modified="2014-03-19" version="1">MTETKSAPRRTSRSKGLHVERIFSTEGVHPYDEVTWERRDVVQTNWRTGDVVFEQRGVEFPDFWSVNASTIVTNKYFRGALGTPAREDSLKTLIDRVVNTYVTTGRKNGYFASDDDVKVFGEELTWLLVHQYFSFNSPVWFNVGTTSPQQVSACFILSVDDSMESILNWYREEGFIFKGGSGAGLNISRIRSSKELLSSGGTASGPVSFMRGADASAGTIKSGGATRRAARWSSLISITPISKSSSRPRRARRTRFVLCAMPGSTWTWAGATSSVFNIRTPTTRCVSSTPSWLLLSRVSPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF81</accession>
    <name>W4TF81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67416">
        <property type="protein sequence ID" value="GAE67416"/>
        <property type="gene ID" value="JCM18909_475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="3">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="395" mass="43884" checksum="BC45FE771F308345" modified="2014-03-19" version="1">MYAFRPWTIRQYAGFSTAKESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDNPRVPGDVGMAGVAVDSILDMRELFAGIPLDRMSVSMTMNGAVLPILALYVVTAEEQGAKPGQLAGTIQNDILKEFMVRNTYIYPPLPSMRIISDIFAYTSANMPKWNSISISGYHMQEAGATADIEMAYTLADGVDYIRAGESVGLQVDQFAPRLSFFWAIGTNFFMEVAKMRAARMLWAKLVHQFNPKNPKSMSLRTHSQTSGWSLTAQDVYNNVIRTCVEAMGATQGHTQSLHTNSLDEAIALPTDFSARIARNTQLFIQQESGTCRVIDPWSGSAYVEKLTLELARKAWAHIQEVEKAGGMLRPLRRASRRCVSRKLLLVPSPYRLGPSASHRCQQVPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFF5</accession>
    <name>W4TFF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron transport system substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67496">
        <property type="protein sequence ID" value="GAE67496"/>
        <property type="gene ID" value="JCM18909_559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="197" mass="21089" checksum="7EBDD40C3AF05BD5" modified="2014-03-19" version="1">MGTREELKKQGIATYISPFGCPKGTPSAEATWENVWKEMREVGTLIGQKDAADKVIAEQRTSLKEVTGNKHGNGTSIVWFDSGDKVPFIGAGHGGPQLLMDAVGAKNLFANLDGGWADGSWEKIVGSNPDVIVVADADWSTAKDKIAYLKKDPVLSQMKAVKENKFVTVPFSRTTPGAELVDGAKTLNDGLVRVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFP3</accession>
    <name>W4TFP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67596">
        <property type="protein sequence ID" value="GAE67596"/>
        <property type="gene ID" value="JCM18909_669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="168" mass="17890" checksum="C7D6F8F7234E621E" modified="2014-03-19" version="1">MSQVATTAIGDIPLVPIAEELGGHHRDDWELVVDELVTRMVRSLFDGATRLTDATLAAHVVVKVVGNQERAGRSFDYARPFVSNVTGQTVPGLVVALAWFDGDVELLNDAALAEVKDLDAAYRLGTERLASALVGELSFSRDGDVLVVAGVVMAVGEGSGAPHRQRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV9</accession>
    <name>W4TFV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67855">
        <property type="protein sequence ID" value="GAE67855"/>
        <property type="gene ID" value="JCM18909_945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7894" checksum="FAE2407C1A1A06C1" modified="2014-03-19" version="1">MRCSSRSLTVDDKAVSVGLSAQDIDAGPFLNFNLQRKQVLGHLGYKSQDIALLAEMLSYYRLDLTESISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG44</accession>
    <name>W4TG44_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67915">
        <property type="protein sequence ID" value="GAE67915"/>
        <property type="gene ID" value="JCM18909_1013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15088" checksum="1AEDB78D1E533126" modified="2014-03-19" version="1">MASLGLFLFRLIVGGILGVHGFQHLAQRDLTLRAVQALPLPSGYAQAGVWVLGICECIAAVCIILGMFTRVAGAGIIAIMVLTLTFIFWGSFAIFKAMGFKGELELLLAACGVLLLFLGAGGWSIDAAYRRSRAAAKAEEVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG55</accession>
    <name>W4TG55_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67925">
        <property type="protein sequence ID" value="GAE67925"/>
        <property type="gene ID" value="JCM18909_1026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="269" mass="28819" checksum="01B5DD2104C5581F" modified="2014-03-19" version="1">MGGISQLSGERVVTCPAAVNGPLPLVIEYLGYSSSRGVPIGSAFAAAGYAHIVVDPRGQGWGHPILTENCPDVHDGSGAPGFMPQSLSDPHGHYYRRLFTDAFRCLQAAREMELVDSTRIAVLGHSQGGGRAIAVCALAAMRGIKLAGAFVDVPFLCHIRRSCDIATDGPYLEVVRYLAAHPSLCGRAFQTLGYFDGLHFARRARTSTWFSVAMMDQAVPPSSVWAAYNAWGDGMVADKHIAVYPFAGHAAGEDVQRWNQLGVLAQLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC6</accession>
    <name>W4TGC6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67841">
        <property type="protein sequence ID" value="GAE67841"/>
        <property type="gene ID" value="JCM18909_929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19994" checksum="F81B5069800EEDEF" modified="2014-03-19" version="1">MRLPDFDGLEAMRQIRMNQPTVPAVFLTAKDAISGRIAGLTAGGDDYVTKPFSLEEVIARSRALLRRSEATEPKSDSMLTVGDFTLDEDSREVRRAGEEIHLTTTEFELLRYFMRSPKRVLSKAQILDRVWNYDFRGQANVVELYISYLRKKIDRGHKPMIHTMRGAGYVLKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG9</accession>
    <name>W4TGG9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67508">
        <property type="protein sequence ID" value="GAE67508"/>
        <property type="gene ID" value="JCM18909_572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7193" checksum="6FE856687E67F532" modified="2014-03-19" version="1">MAEQDEYFWCLKHHAVEGADECKAADHLGPYPTPQAAAEALDTVAARNDAWENDPRFNDDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL7</accession>
    <name>W4TGL7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clusters with Methylmalonyl-CoA carboxyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67906">
        <property type="protein sequence ID" value="GAE67906"/>
        <property type="gene ID" value="JCM18909_1000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8818" checksum="F616B0F2A30602D4" modified="2014-03-19" version="1">MSENNELVIETLNKRLAALEAEVSRLKKTSKGVPEDVLAAICAAVSAYLGNDGKVQAVRFAPSETWVRQGRRAQQNYSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM1</accession>
    <name>W4TGM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67911">
        <property type="protein sequence ID" value="GAE67911"/>
        <property type="gene ID" value="JCM18909_1005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014487">
        <property type="entry name" value="DUF3151"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11349">
        <property type="entry name" value="DUF3151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20810" checksum="D4A1BF73610F3EC9" modified="2014-03-19" version="1">MCSPHPAQVVLPQTPHLTGRHMVIILSLAETSLLSYSFIDGPNKRRGAFRPRLGIMAEEQNTDLTTEIEGQDHGVRLPPDPAIRKLAKRGRGEFMTVVKEHPSSSLCWALLAEGSLSSDTDAADVAAYAYARTGRDLGLEQLRDAGWDGEGPVDWGYLPNQGVFRCLHALAMRPSGLDLGMSPTTPTPFCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP0</accession>
    <name>W4TGP0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68135">
        <property type="protein sequence ID" value="GAE68135"/>
        <property type="gene ID" value="JCM18909_1253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6014" checksum="BE03D929265CFBD9" modified="2014-03-19" version="1">MATFRTDPSHPRRRGLEGRPAWVDPIRMVMIRVVIEVGTTVWAQPSAVIATQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX1</accession>
    <name>W4TGX1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protoporphyrinogen IX oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68016">
        <property type="protein sequence ID" value="GAE68016"/>
        <property type="gene ID" value="JCM18909_1122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14181" checksum="9C0342C146E8111B" modified="2014-03-19" version="1">MPAELRRQAEQAGATTMTRVGARGLTRHGDQWLVETAGTSRNPDPSLPPVTDGEIRSFLTPRVVVACSAGPATKLLSNVIDTVGPEMAPGAPIGHVNLALQAPELDSSPRGNGMLVAPGTTTVTAKHLPTCRRSGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX5</accession>
    <name>W4TGX5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase eubacterial/eukaryotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67678">
        <property type="protein sequence ID" value="GAE67678"/>
        <property type="gene ID" value="JCM18909_755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7687" checksum="AD34BB3BE7EB49BD" modified="2014-03-19" version="1">MFTGIIEEIGEVLAIEKGRDSARLAIRGPLVCSDARLGSSIAVNGTCLTVTDLDEASFGCDVMAETLNRTALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY6</accession>
    <name>W4TGY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67797">
        <property type="protein sequence ID" value="GAE67797"/>
        <property type="gene ID" value="JCM18909_882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7459" checksum="8DBEB219E0C1591E" modified="2014-03-19" version="1">MGFGDFGWGKGGNRLGAGTWRCARGDVPWLGMAGLWVRGLLGHDPPGDGLFQPRRSGQSREYELAWLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH00</accession>
    <name>W4TH00_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67708">
        <property type="protein sequence ID" value="GAE67708"/>
        <property type="gene ID" value="JCM18909_787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="30262" checksum="559680684F13BDC4" modified="2014-03-19" version="1">MRRRPAWLGGPGKDADGAVLLTGPEAGELLKAAVEHAGGGLVGWHLDHVDANPGQSTTATYQARVQWPAGERQELFGMSARASGPAVTDSRADIYVDGSREVAVWRYPDDPDLPGLSRAAYPEQMAAIISDLNLVGARVSAQQINLHMIGYRPRRRAVLCVEVNNRRFYVKVLRDGIFQATLARHDLLTRASVPSPRVAGVTEDNLLFFSPNCRDAHLARRYLNQEVRAPPRALLVYSTSYLRKCVTFRAGHRGANRSLTTAVWSQLPCRTRVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH20</accession>
    <name>W4TH20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67728">
        <property type="protein sequence ID" value="GAE67728"/>
        <property type="gene ID" value="JCM18909_808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="187" mass="20308" checksum="609FD56B573756DC" modified="2014-03-19" version="1">MCVTPTAPAHAQGLERFSWSHESIGRCDTWMSYGFSTRAESAYVPYAFPIDSAAVARTIILLAGPSGSGKSRLTHMADLPELRLDDFYRDHDEPGLPVVRNMVDWDDVASWNLPVAVEALGELATTGHTVVPCYDISRSRADGNHVVEVGDAPAVIAEGIFLPPTCWSHVCRRASTCYRSGWTGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH50</accession>
    <name>W4TH50_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67758">
        <property type="protein sequence ID" value="GAE67758"/>
        <property type="gene ID" value="JCM18909_840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="40" mass="3853" checksum="C6C8A0A9E2903CD3" modified="2014-03-19" version="1">MIPAPKPGQSGTPGHDVNLGTPGSDKGSSNGKPGLPKTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH71</accession>
    <name>W4TH71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67778">
        <property type="protein sequence ID" value="GAE67778"/>
        <property type="gene ID" value="JCM18909_861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7570" checksum="F8F18B2E44614FE9" modified="2014-03-19" version="1">MTKKSSLVLAMASIGAIAVGLTGRARQLTLAFNSASWVVAVIALSYLIRSGHSQKAAWLAQPPRVPEAQPPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD5</accession>
    <name>W4THD5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-galactosidase fused to beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67564">
        <property type="protein sequence ID" value="GAE67564"/>
        <property type="gene ID" value="JCM18909_634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_dom4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BetaGal_dom4_5" evidence="1">
        <location>
            <begin position="68"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="261" mass="27286" checksum="CEC2F25EC94D3DB2" modified="2014-03-19" version="1">MAAPSPERPNDRAGTVSIIPDAAITSASWNGRPLPHLTDAPVPGPAAVSAPTLHWVSKTGAPEATQGYDDSTWKVASSATGRTPWQKPTLGGAALDSNLLGFYEGSVWYRAHFTADTTRTLKLNANGGQGAPKPNGVDPAFMQVWINGTYTGAHRAIGNTTSIELPSSVKAGDPVVLSVVVHNLGQNLDWSDNGLSRQSRGLNSASLPAKGAVTWRVRGALSTEQTAIPPGRCTTMVACTASAPDGICRACPTRTGQRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK2</accession>
    <name>W4THK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rhomboid family serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S54.A08"/>
    <dbReference type="EnsemblBacteria" id="GAE67987">
        <property type="protein sequence ID" value="GAE67987"/>
        <property type="gene ID" value="JCM18909_1091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rhomboid" evidence="5">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8313" checksum="9DFA357EE825C6D7" modified="2014-03-19" version="1">MVKPQVGEAVVLAPRVGFTEPWRFVTSMFGHALSIFHIGFNMYALWALGRSLEPSSDAPGSSLLTSCLAWVVGRCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL5</accession>
    <name>W4THL5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68291">
        <property type="protein sequence ID" value="GAE68291"/>
        <property type="gene ID" value="JCM18909_1415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21453" checksum="BC87A849415ADC9C" modified="2014-03-19" version="1">MGAIVGLAQTDMKRLLAYSAIAHAGFVLVGVVGAWTTQTGMAEGQTGSVSSVLVYMTAYGLASIGFWLLILMVRRAGGESTEIASWAGIGRSHPWIGVLVVIFVLSFAGIPLTAGFTGKLVVFLAGWRGGYAWLVLIGVLFSLVAAAFYLRIIVVVFFPVRERGRRPRGGCRALHRRMDHPHRVRGVHHCHGCCPTADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ4</accession>
    <name>W4THZ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68396">
        <property type="protein sequence ID" value="GAE68396"/>
        <property type="gene ID" value="JCM18909_1531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="1">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11291" checksum="1EF53480C6DC6F5C" modified="2014-03-19" version="1">MATTTTISQVGEFPLISSMVGDLTMGQAVTLGPGDDGAVFQVDGSAVVSTDVLVEEVHFRRRWSTATDVGRKAVAVNVSDIEAMGAVPVASSSGFPLPVIFRRPGPVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI22</accession>
    <name>W4TI22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysophospholipase L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68177">
        <property type="protein sequence ID" value="GAE68177"/>
        <property type="gene ID" value="JCM18909_1296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="15382" checksum="3F83F87A25AD85DA" modified="2014-03-19" version="1">MGGIAVQSYGIMYPGTVDGIVSSGGGTIVNVDGPDTEGATTITPDNLNFFARHALPQISQLLPMAQLTSFNGRLVKDLVKKIPRRFGCLRVRCLLTSFCPATRHTAYAPIRRSASTTGTATRCTTITCVSDSSSRWVSPRLTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI73</accession>
    <name>W4TI73_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68232">
        <property type="protein sequence ID" value="GAE68232"/>
        <property type="gene ID" value="JCM18909_1355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="4689" checksum="3DC34E59990FF6BC" modified="2014-03-19" version="1">MSEQNLMESTDHGTTDVVPPVKRNRGRGGKPQFGLTGARCWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI85</accession>
    <name>W4TI85_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68143">
        <property type="protein sequence ID" value="GAE68143"/>
        <property type="gene ID" value="JCM18909_1262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5888" checksum="419BF2C68CDE3149" modified="2014-03-19" version="1">MFDIAEAVCPRGFVNRPTNIGRREPHNPDLDYPRHTRSGDGGCCRHCWSFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI89</accession>
    <name>W4TI89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Manganese transport protein MntH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67869">
        <property type="protein sequence ID" value="GAE67869"/>
        <property type="gene ID" value="JCM18909_960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="395" mass="40822" checksum="70E4727FCA359C0C" modified="2014-03-19" version="1">MGPAFVAAVAYVDPGNVAANLAAGAGYGYLLVWVLVVANVVAMLVQYLSAKLGLVTGHSLPELVGEALPRRGSRLAYWFQAELVAAATDLAEVIGGAVALQLLFGLPLIVGGLMTGALSLAILAIPSRHGQRTFEIVIIGMLVVIAIGFTAGLAFSPLSWGGVASGLVPRFEGTETVMLATSMLGATVMPHAVYMHSSLVRDRHGTDDRPKRITTLLRATRWDVGVSLVLAGSVNIAMLLLAAASLQGVKGIDGIAEAHAAMSNSMGPVVGLIFAVGLFASGLASTSVGAYAGAEIMAGLLHMRVPMLVRRLVTIIPALIILASGANPTQALVWSQVLLSMGLPLVLVPLARFTGNRRLMGQWTNGRVMAAIAWIVVAAVSALNVVLVVETVMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI94</accession>
    <name>W4TI94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein MraZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68680">
        <property type="protein sequence ID" value="GAE68680"/>
        <property type="gene ID" value="JCM18909_1831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MraZ" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5908" checksum="2AEF113762F2E14E" modified="2014-03-19" version="1">MFLGTHTPKLDEKGRFFLPAKFRDELDDGWSSPEARTGVWRSTRPKLSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB3</accession>
    <name>W4TIB3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67889">
        <property type="protein sequence ID" value="GAE67889"/>
        <property type="gene ID" value="JCM18909_981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="267" mass="28773" checksum="24A540AAE08F7C25" modified="2014-03-19" version="1">MSRLLPDPDVAGAWRVRVGGADQSWIDPDDPTRLEFDYMQRIADHLDVHRPAGERMRVIHLGGAGMCLARYVTATRPTSPQIVCEPDAELTAEVRLKVPLPVRSGIKVRPVDGRSGVAAMREDFADVVILDAFDGARVPGDLVTVEFFADVSRILHSDGIGVANLADSAPLVWTKRVARSIKEVFSNVCVAAEPATLKGRRYGNIVLAASNGPLHEEELIRRCSGAVVPFRFIAGDALAKLLADARPFHDGDTESSPGPPGGATFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID0</accession>
    <name>W4TID0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68188">
        <property type="protein sequence ID" value="GAE68188"/>
        <property type="gene ID" value="JCM18909_1309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="12812" checksum="75B4966B1102EA90" modified="2014-03-19" version="1">MNKEFTVDVLVIGWGKAGKTIAGRLAAEGHKVALVERSAQMYGGSCINIACVPTKDLIDSASKRDGRDPVSYFTSAVADRDTLVATLNRTNHAMLEGKVLLLDGVASFTGPHAVKVVGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK8</accession>
    <name>W4TIK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68616">
        <property type="protein sequence ID" value="GAE68616"/>
        <property type="gene ID" value="JCM18909_1763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6376" checksum="0A831E5E4A1915EA" modified="2014-03-19" version="1">MGPAEEVLTEDNLTTVYRWPIEVVTLPGGELVILPRRARTASHDERRKPCRVQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL0</accession>
    <name>W4TIL0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="2">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoC</name>
        <name evidence="4" type="ORF">JCM18909_1392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68268">
        <property type="protein sequence ID" value="GAE68268"/>
        <property type="gene ID" value="JCM18909_1392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="3">
        <location>
            <begin position="65"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24826" checksum="BB26C466422E8531" modified="2014-03-19" version="1">MWGATSGPGDTSGYGGIVRTVEISGNSERPYGGWFDEVVDRMAELVPDFSDGLTVVDRGEITFFVRPEKLLELGKVLRDDDALRFESCTSLTCVHYPHMAGREMHVVYNLLSMTHNRRIRLEVALADPGQEDVARTGRSDVDSLPHVPSVVSVYPHADWQEREAWDMFGVIFFDGHPALTRILMPDDWVGHPQRKDYPLGGIPIEYKGAVVPPPDQRRSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP7</accession>
    <name>W4TIP7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate-1-semialdehyde aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68009">
        <property type="protein sequence ID" value="GAE68009"/>
        <property type="gene ID" value="JCM18909_1115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="305" mass="32017" checksum="FAFA57C486677DCC" modified="2014-03-19" version="1">MTSNAELFSAAQAVIPGGVDSPVRAYGSVGGVPRFIEKAQGPWIWDAEGTRYVDLVCTWGPALLGHARPEVVSAVQETASKGLSFGAPTRTETELADAIIERMDPVEKVRFVSTGTEATMTAVRLARGATGRDVIVKFAGNYHGHSDALLAAAGSGVATAGLPGSAGVPAASTADTIVVDYNDVAALDAVFSERGDQIAAVIVESCPANMGVVPPEPGFNAAIRRLTTEHGALMITDEVLTGFRCSPSGFWGLQQQAGEDFAPDIFHLRQGRGRRHAAGCPRGARRCHGLAGSYRPRLPGRHFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIW3</accession>
    <name>W4TIW3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_1601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68462">
        <property type="protein sequence ID" value="GAE68462"/>
        <property type="gene ID" value="JCM18909_1601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDDEXK_1" evidence="9">
        <location>
            <begin position="101"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="295" mass="32277" checksum="917B8FE39B343B5D" modified="2014-03-19" version="1">MLGTVWPDFGERPDDDIQAGTPWPVFAKDVGHGLIDNACRSVDDPGQADRVKAWRTDADALLKDARRHIDLQDEVALPPRLTTSQVVRLRANPQAFRDDLRRPMPRPADRGAGIGTAFHEWVSQWLAPAEPIPLFDAEEIAELDEENTTQEAVAAEPSGAENRALRSLCQAFEESRWAGATVLAVEKSFVMTIGQTVVRGRLDAVVADLDHPGDELVIDWKTSPPRSADPLQLSIYRLAWAQARGIDPSKVRAVFHHVGANETISAEPFLDADQVAAILTASSSENRPTKNASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ33</accession>
    <name>W4TJ33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68950">
        <property type="protein sequence ID" value="GAE68950"/>
        <property type="gene ID" value="JCM18909_2127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB_MalK" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="23786" checksum="F2D2327165625DD6" modified="2014-03-19" version="1">MGRAIVRNPQVFLMDEPLSNLDAKLRVQTRTQIAALQQRLGVTTVYVTHDQVEAMTMGDRVAVMRDGVLQQVDSPLALYDTPKNLFVAGFIGSPAMNLMEGDVVDGGVELGDYVVPVSRDVLAKAPNETKLTLGIRPEAFTLASEGIGLDVAVVEELGADAYLYGSLVGSGKQASIEDGEAHQVVARISSRRPPQRGEQVRLGVDPASVHVFSQETTERIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ42</accession>
    <name>W4TJ42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68965">
        <property type="protein sequence ID" value="GAE68965"/>
        <property type="gene ID" value="JCM18909_2143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9209" checksum="6DBF752EB638A1FE" modified="2014-03-19" version="1">MDALHTGTGWRSSARVQLCDADLTAIAGEMGKVLALELARMFFLVLPISTDGQNPHDPVLTSSADHPSGSSDDPTLRPHRAGKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ55</accession>
    <name>W4TJ55_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68194">
        <property type="protein sequence ID" value="GAE68194"/>
        <property type="gene ID" value="JCM18909_1316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11033" checksum="2F3367DB2092AE35" modified="2014-03-19" version="1">MIAYGFAVMQRTSLGVMGLTAAAHFNAPASVVATFMVLQLAVYAVLQIPAGITVDRLGSRVVITAGSIVMTVGQVVMALTGSVGGAVLARVLVGCGDAFIFLVRRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA2</accession>
    <name>W4TJA2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ornithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68483">
        <property type="protein sequence ID" value="GAE68483"/>
        <property type="gene ID" value="JCM18909_1624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="362" mass="38777" checksum="BC5A6428384559F8" modified="2014-03-19" version="1">MNRPTPRLEIFADRIRDNARAIVTQCAKHGVQVAAVTKVLHAHPVLLQALEDTDITMLADSRLQNLRQIAECGTSLPTMLLRAPGRHDIDDTVQLADISLNSSLTTMTALSEAAVRAGSRHGVIVMVDVGDLREGVWPDHLVDVVSAAAALPGIDVKGVGTNLACYGGVQPSVENMTRLVQLRDMARAATGLELGLISGGNSANLPLMMSGAMPSEINNLRIGEAIILGRNTLDRSPWPQTRQDTVEVVAEIIELERKPSIPLGRTGEDAFGQHVTFTDRGIRLRAICNLGRQDVNPSDLAPVDPGHIVLGASSDHLIVDMTDSSESVEIGTEVRFWPTYAGLLATATSSAVWKAAATPHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJF4</accession>
    <name>W4TJF4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69085">
        <property type="protein sequence ID" value="GAE69085"/>
        <property type="gene ID" value="JCM18909_2269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="18642" checksum="D4F85F0335937D74" modified="2014-03-19" version="1">MCDATSPGSAVCRRRRLGTLSGCKGSANDPAGITEVSDAPAASVPSVSQSSGPKPTPQDVNPNTKLTATPQRGGLKDFLPGVSGIISDRVVTGSTSQTVVVKAGTVTDYYFLCDTTDALMSVTENDESTTSTPCHEGFAHLSVGKRAQSGQIELHIDAPENVTYEFVIIENPAENQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL7</accession>
    <name>W4TJL7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69150">
        <property type="protein sequence ID" value="GAE69150"/>
        <property type="gene ID" value="JCM18909_2339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="378"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="422"/>
            <end position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="616" mass="67124" checksum="B7B954B890E68AD3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP7</accession>
    <name>W4TJP7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68364">
        <property type="protein sequence ID" value="GAE68364"/>
        <property type="gene ID" value="JCM18909_1493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="311" mass="33991" checksum="57E0BE608806AC22" modified="2014-03-19" version="1">MIHRIDYIPDPHYHRMDAQALWTALGIVLFVATLLILRDHRNLQRYPYVLFIVGLVFLMLPLVPGLGMETLGSRVWIHVGSYTFQPAEVSKVVLAIAFAGYLVDNRDVLSRAGHKILGITLPRARDLGPIAVMWVATMLVIVYQNDLGTGMLFYSMFVVMLYITTERVGWAILGAVSFLGGAVLAYTCFGHVRVRFDSWLHPFSNYTQNYQIIQAQFGLAWGGLAGRGWGLGRPGMVPLAWSDFIATSIGEELGVTGSWLSSCSSSSLPPAECALASVAVMTSVSLWSLACPSPSPCRSSPSSVASPASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK29</accession>
    <name>W4TK29_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68788">
        <property type="protein sequence ID" value="GAE68788"/>
        <property type="gene ID" value="JCM18909_1950"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="6">
        <location>
            <begin position="47"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="301" mass="31510" checksum="4D092A7B49ADFBF0" modified="2014-03-19" version="1">MVTLTSAIPPILGHVVVTRRQFPTSLGRPSRLASVTKIALAIAGSEASGGAGAQTDLKTFHQLGVFGCTSLTCIVSFDPHNDWGHRFVPVDPQVIHDQIEAAVAVHGRIDAVKIGMLGTPTTIGVVAEALESYQFPRVILDPVLICKGQEPGAALDTDNALREKLLPRADVITPNLFETQTLAGVDEITSVDALKDAAKRIGDQGVPVVIAKAGTLLDTGTALDVYYDGHDCEVLDVPAVGQERVSGAGCTLAAAITAEIAKGASALDAARTAKQVVVSAIENRMHGNAPFDCVYQGNYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK82</accession>
    <name>W4TK82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69211">
        <property type="protein sequence ID" value="GAE69211"/>
        <property type="gene ID" value="JCM18909_2405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017501">
        <property type="entry name" value="Phage_infect_YhgE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03062">
        <property type="entry name" value="pip_yhgE_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="430" mass="45477" checksum="933867290A96D746" modified="2014-03-19" version="1">MTGTLQNPNGDSVVKIQHDVTGVVNKTTALAAKHPELAGDPDYIALVKQINGAASSTTTVSSNIAAVANVSAGLNLSLNQQNADTLANNATAALGRLNKDAQQVNNGLETINGAMDTADSAAKDLNKAVNDATDAGRSFTAKAPQIASGVMQLSNGLGQLKSGSDNLSKGATQLHRGLDSGAKQIPGLSDDKRSNLANIMSSPVDIEQTVLHSAKYYGRGLAPMFFSIAMWIACISTFLVVRTFSGRAMTGRANSLSIALVGFGPLAVIALAGAYIMAFGVWLTLGLDPVHPWYFIGFVTLTSLSWMMLAFWMRLIVGSPQTAIFLILLVLQLPTCGGTFPVTMLPPVYQKLAVVMPMKYSVDAFRVLISGGPMSTLALGFAVEGGILVISTIITLVLVHRHKLFRMRDLHPPMITSTSTADFAFSVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC7</accession>
    <name>W4TKC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lead, cadmium, zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69251">
        <property type="protein sequence ID" value="GAE69251"/>
        <property type="gene ID" value="JCM18909_2447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="426" mass="45099" checksum="ED96B1C084ABE697" modified="2014-03-19" version="1">MLTPTHPDAQSELKDTTEPTSVNLDITGMSCASCAARIAKKLNKVDGVQATVNYATSKAHVLTTKPIEVDDLIGVVEAAGYGASVPTPAVPPEDHAAKIRTRLVVAVILAVPVMLLSMIPALQFDGWQWLALALSLPVVFWCGEGFHRVAWTNLRHGATSMDTLISLGSLVSLGWSVWALVWGNAGHVGMRHRMTWALERTDPSSALYLEASVGVITFILIGRWIEARNRAEAGSALQALLRMGAKSVRIIRDGQEVTVPIEALTVGDHFVVRPGEKVATDGRVTEGSSAIDASLVTGESLPVEVTVGDEVIGATVNTSGRLVVEATAVGSDTELSRIATLVEAAQTSRSKTQGLADKVSSIFCADSFDHLSSDDDRVGCIGSGRHGGFHRWGGGSHHCVPLCPGLGDPHGPACWHGSRCPVGNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE8</accession>
    <name>W4TKE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68997">
        <property type="protein sequence ID" value="GAE68997"/>
        <property type="gene ID" value="JCM18909_2176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8866" checksum="CDF824DC0B6B775B" modified="2014-03-19" version="1">MRVCEVSPGMVHTEEFSLVRFHGDQAKADKVYQGVGSPLVAADIAECVRWISGLPSHVNIDRMIVRPRAQAAQYKVARES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG7</accession>
    <name>W4TKG7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68654">
        <property type="protein sequence ID" value="GAE68654"/>
        <property type="gene ID" value="JCM18909_1805"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="8757" checksum="2096B562EF396147" modified="2014-03-19" version="1">MVSTGLRTVGHLTCVAQSVADVEQMVADYAESGIGHILAIRGDMLGGVGQPWVAHPWGLPNATELVRLVKRVHPEACIGREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI1</accession>
    <name>W4TKI1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GntR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68669">
        <property type="protein sequence ID" value="GAE68669"/>
        <property type="gene ID" value="JCM18909_1820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="68"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FCD" evidence="5">
        <location>
            <begin position="155"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="300" mass="32851" checksum="E0AA147422F85AF6" modified="2014-03-19" version="1">MGERGESRQCRRNHTFVPCEQVFLVLLRCCCTVPKMHFSDRSLRVSGLVGLACVIVPVMPQEFLASSVASRLGARIVDGDLQAGDVLRLGDIEQESAASRSVCREAVKILESLNLVRSRRHVGVTVLPSNQWDVLSPKVVHWYMSGNKREQAMSWTNELWIALEPTAARLAAERADGADLKGLQDAVSGMTEAIRNDDSTSFAKHDHAFHRSLLAATRNPLYIAHVPMLLSYFAEQHDDRNLTSEDGADLVQHRDILDAITMSDPDAAERSTRALVLGLGRVLPQPTVASGPAGVAHQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI9</accession>
    <name>W4TKI9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69042">
        <property type="protein sequence ID" value="GAE69042"/>
        <property type="gene ID" value="JCM18909_2224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045598">
        <property type="entry name" value="DUF6457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20058">
        <property type="entry name" value="DUF6457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6457" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8828" checksum="D3C314C55D650FAF" modified="2014-03-19" version="1">MARMRDWLEIAAREVDVDPSVLTDVEQPLLDMVSVISHGPSRPGAPLTAFLVGIATAQGGDTLQLVKKLMQVAEQWGQTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ6</accession>
    <name>W4TKJ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68684">
        <property type="protein sequence ID" value="GAE68684"/>
        <property type="gene ID" value="JCM18909_1835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850783" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8150" checksum="C817E46EE7D9EF41" modified="2014-03-19" version="1">MAAFLVLAVSLASRALQLQAIEAPAYAASAAARMKYTYALQPNRGELTDRNGIVMAQTQPAVLVFCGPSDDLPQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM6</accession>
    <name>W4TKM6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription-repair-coupling factor</fullName>
            <shortName evidence="5">TRCF</shortName>
            <ecNumber evidence="5">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mfd</name>
        <name evidence="8" type="ORF">JCM18909_2266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69082">
        <property type="protein sequence ID" value="GAE69082"/>
        <property type="gene ID" value="JCM18909_2266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="93"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="272"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="636" mass="70222" checksum="071862C0EBE79F8A" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN0</accession>
    <name>W4TKN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68968">
        <property type="protein sequence ID" value="GAE68968"/>
        <property type="gene ID" value="JCM18909_2146"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SHMT" evidence="8">
        <location>
            <begin position="99"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="424" mass="45591" checksum="F41D4C35E5D5D36A" modified="2014-03-19" version="1">MGTWFSDKYAEGTAGHRFYAGCQNVDTVETIAAEHACTLFGAEHAYVQPHSGIDANLTAYWTILAHHIETPALSEFGARTVNDLTQADWDTLRHRFNDQRAIGMSLDAGGHLTHGFRPNISGKMFDQRSYGTDPQTGLLDYDKVAELAREFKPLVIVAGYSAYPRRVNFAKMREIADEVGAVLMVDMAHFAGLVAGKVFTGDENPIPHAQVVTTTTHKSLRGPRGGMVLTTKDYADDVDRGCPMVLGGPLSHVMAAKAVALAEARTQAFRDYAQRVANNAKALAEGLMKRGVKLVTDGTDNHINLLDVTTSFGLTGRQAEAALLDAGVVTNRNSIPTDPNGAWYTSGIRIGTPALTSRGFGPDEFDQVAELIVTTLEATTPMTASTGKPGKAKYQIADGVAQKVHDAADELLGNFPLYPGLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN4</accession>
    <name>W4TKN4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-asparaginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68973">
        <property type="protein sequence ID" value="GAE68973"/>
        <property type="gene ID" value="JCM18909_2151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="SSF53774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asparaginase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase_C" evidence="2">
        <location>
            <begin position="117"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="242" mass="25658" checksum="7E0A4E7826EA2883" modified="2014-03-19" version="1">MAYTSAALSYALTEFSKPVVVTGAQYSLGVVGTDAAPNVTGALRAATSGRLNGVAVFFGHKLLRSNRVTKLSSWAYNGFDSPAVPQLARTGAPWQWVENESTGCGWLNPGPYQRHDVLVVDLSPGISARRLRAVLDPLPEAVILRAFGVGNVPSDEPDVVDAILDVISAGTPVVVASQCMQADVQLGQYQSSHALTEGGAVSAHDMTLEALYAKLIFLLSQGLHGKELKRWIETDIAGEISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN5</accession>
    <name>W4TKN5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69092">
        <property type="protein sequence ID" value="GAE69092"/>
        <property type="gene ID" value="JCM18909_2276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="229" mass="24328" checksum="C469F264AF5E077A" modified="2014-03-19" version="1">MTFDDVLGCTGLVLLIIAAIGAVSFTLIGPNVVASGPALVVGSIAAFITAMVVSTRRTVPVGGVIFYCICEGLVLGSLSAMFETAYPGIVVQAVLGTFAAAGVTLAAYKFFNIRVTPRFRQIVIISTFGFALAMLINLVLMLFRINIGVASFGPIGILCSALGVVLAAMNLVVDFDYAEQGVRNQAPASESWRAAFGIAVTMVWLYTEILRILSYFRLIDIDARGAWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP1</accession>
    <name>W4TKP1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myosin-crossreactive antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69356">
        <property type="protein sequence ID" value="GAE69356"/>
        <property type="gene ID" value="JCM18909_2564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="460" mass="52917" checksum="3F4E36AE386448F2" modified="2014-03-19" version="1">MPGENITILEEMSEPGGAFDGAGDTEKGFIARGGREMGQHFECFWDIMKDIPALEIPEPYSVLDEFRIVNENDPNINPCRIINKRDASKMGLNKKGQLDIVRLLLAKEPDTYYKSIEDWFDEDFLQSTFYLLWKTMFAFEQWQSLTELKWYMHRFLQYLPGFSNLSCLRFSRYNQHDSFVVPLVKWLTEKDVNFQYDALVYDVDLEITAHRKVARGILWRDKEGGEHRIDMSAKDLVFVTNGSLTECTGYGDMDTPAPYHKDMQAGWELWRNLVRRSPAFGRPDVFCGDADKTVWQSISFNFIGRDHPFLKKIKELTGNDPLSGRTVTAEDSSWCISLTMNRQPQFHGQPEDWGVAWAYGLYPFEKGDVVNKTMLECTGEELLKEYCYHFGLLDQFEEVKAHTKVRIATMPWITAFFMPRGKGDRPQVIPDGCVNLACLASSSKPPMTASSPPRVRHAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS4</accession>
    <name>W4TKS4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane alanine aminopeptidase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68759">
        <property type="protein sequence ID" value="GAE68759"/>
        <property type="gene ID" value="JCM18909_1916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="3">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="4">
        <location>
            <begin position="157"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="528" mass="57754" checksum="D6143D1C2F6C41E3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU1</accession>
    <name>W4TKU1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69043">
        <property type="protein sequence ID" value="GAE69043"/>
        <property type="gene ID" value="JCM18909_2225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8278" checksum="469CCF0E1FC71217" modified="2014-03-19" version="1">MMSLIDFFESGGVASEMFEASVGDLSGAVRKWLSYLLRSFQLHQDGQDAASEQGDLVTGFCLSAGHREQRSAATIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL38</accession>
    <name>W4TL38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69685">
        <property type="protein sequence ID" value="GAE69685"/>
        <property type="gene ID" value="JCM18909_2930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849296" evidence="1">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="197" mass="22054" checksum="2BC6B0C2B3936338" modified="2014-03-19" version="1">MQTRKNLRRSVVLAVLMTLIASVFAPMSWARDAKVVLSKNHTDVFYITTDTGVPVVKVANGLHSRMYDPNDVEFQIQSDTYGKQYKLTGLSESPLESYYTGSENTAEWFEPGWNAPGFTKNGFDALRVDFTAITGPGKMYLVGNSPEADENGKLGAFLAGDTYQVVKGASLPIKGHQHAHWFFHSRRHIHHEWGCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL44</accession>
    <name>W4TL44_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68884">
        <property type="protein sequence ID" value="GAE68884"/>
        <property type="gene ID" value="JCM18909_2055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11432" checksum="D25605B31A17D487" modified="2014-03-19" version="1">MPLAHAWHLAATTGALLAPAAKSVAEGTARRARLEATLDSELAAARASGRIMGLLPLVGLLMGHVVGAHPTVFLTTTWLGRACLLGSTLLACVGVLWSESLADRVAKEALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL94</accession>
    <name>W4TL94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69750">
        <property type="protein sequence ID" value="GAE69750"/>
        <property type="gene ID" value="JCM18909_3001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13503" checksum="1564C098BFA0D49F" modified="2014-03-19" version="1">MPSRLDPRTPSKAGSRSFLDLCQGLGWLWIVVLILGCAWSPMSIPALFVTWWLAWRHPFAAGRLTKALTAVTVAVIIGGAVESPVRTVLAQFAWMSRLGCVIMLGLGFILIDRQLAPDDPGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA9</accession>
    <name>W4TLA9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Di-/tripeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69312">
        <property type="protein sequence ID" value="GAE69312"/>
        <property type="gene ID" value="JCM18909_2513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7290" checksum="746B0894CECF7C21" modified="2014-03-19" version="1">MTLWLLASACGQGLASVTIERTKNLGDVVFYYSLGIVTILVAVVLFVIAPWTQAKMKDVDSVAEEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB7</accession>
    <name>W4TLB7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_3027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69775">
        <property type="protein sequence ID" value="GAE69775"/>
        <property type="gene ID" value="JCM18909_3027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13365" checksum="F1CBF970082AC67B" modified="2014-03-19" version="1">MKGFKDFLMRGNLIELAVAFILGGAFSTVVKSFTTIIMDLIGKLGGTPSFSGWVPGGVHIGAFITDVISFFVMSFVIYFGLIKPIELATEKLKRTKDEPVAAPTTADLLIKIRDELRSRPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF2</accession>
    <name>W4TLF2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69810">
        <property type="protein sequence ID" value="GAE69810"/>
        <property type="gene ID" value="JCM18909_3065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16706" checksum="66A42BF76C37A061" modified="2014-03-19" version="1">MALIQAILPTLVMIANRDRQACLDDYIGEAWVVIVNFPLSRTNKVCTNVALDCLHAISSRRQRSSPETPAESINISAPEVQEPGQVASDLLSAAEELGIITPTSAPVLRSVWVEALDCATAAQRHNTSPTAVRARCSRASRAMRQRRDELLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF6</accession>
    <name>W4TLF6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamin-phosphate pyrophosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69352">
        <property type="protein sequence ID" value="GAE69352"/>
        <property type="gene ID" value="JCM18909_2559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP-TENI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="15506" checksum="BF1BCBA8CF3C9B32" modified="2014-03-19" version="1">MHVGLTDLPVRDARAMLGPDAIVGYTTGTLDLVRSAEPFADALDYVGAGPFRPTPTKESGRSSLGVQGYPALVGASSLPVVAIGDVQVADVPALAATGVAGVAMVRAIMASDDPAAVVRQVVQAFDEPGLADALRRFGGLRLFPRWRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ8</accession>
    <name>W4TLJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Respiratory nitrate reductase beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69034">
        <property type="protein sequence ID" value="GAE69034"/>
        <property type="gene ID" value="JCM18909_2215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10609" checksum="39794140135874F8" modified="2014-03-19" version="1">MWFNNVETRPGVGYPRGWEDQERWRGGWKRTRSGKLVPYQGGRLATLGKIFANPNLPAKKDYYEPWTYEYDQLLASPSTQHIPTARAKSAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM0</accession>
    <name>W4TLM0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69064">
        <property type="protein sequence ID" value="GAE69064"/>
        <property type="gene ID" value="JCM18909_2247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="287" mass="31148" checksum="2BB933867A3306A2" modified="2014-03-19" version="1">MDELDGEVVVTYGDVPMLTGETLQRMVEVHRERRNLVTVLTAEVEDPTGYGRILREGEAVVGIVEHKDADEAQRAVREINSGIYVFDAEALREGVSKLSNDNVQGEYYLTDVVTMAADGTVEVPGRGRVGAFRIDDVWQTEGVNDRVQLARMNAEVNRRIVTGWMRAGVTIIDPTSTWIQPDVDLANDVTLYPGVFLNGATTIGAGATVGPDVTVTDSEIREEATVTRSEVTLAVVGEGVRVGPFSNIRPGSVLDRDAKVGAFVETKNTHIGTEAAIPTWPMLAIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP5</accession>
    <name>W4TLP5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster assembly ATPase protein SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69417">
        <property type="protein sequence ID" value="GAE69417"/>
        <property type="gene ID" value="JCM18909_2627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="257" mass="27971" checksum="17E6182D4E0610E3" modified="2014-03-19" version="1">MATLQINDLHVDVETEAGPKQILKGVDLTINSGEVHAIMGPNGSGKSTLAYTLAGHPKYTVTGGSVTLDGEDLLAMTVDERARAGLFLSMQYPVEVPGVSVANFLRTARTAIEGRAPKLRTWVKEVNEALTRQELDSDFAERSVNEGFSGGEKKRSEMAQLELLHPRFAILDETDSGLDIDALKVVANTVNRYMTDPEHGLMLITHYTRILRYVKPTQVHVYVDGRVAATGGPELGEELEAEGYEKYLSAAKANASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT2</accession>
    <name>W4TLT2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport system permease protein OppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69149">
        <property type="protein sequence ID" value="GAE69149"/>
        <property type="gene ID" value="JCM18909_2338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19110" checksum="87828F4D1E85C787" modified="2014-03-19" version="1">MAEKVILWLIDLLLVIPSFLIIAILSQHTSGKSTSTLLLIVLLSAFSWMLSARVVRAMTLSVVNLDYVTAARFMSVPPFTIIVKHVIPNIASYLIIDLALGVVAAIMSETVLSFFGFGVQKPETSLGTLLGDGMTAVTTSPWLFMFPAGVLVILLLSVNFIGDGLRDAVDPSSKSGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV2</accession>
    <name>W4TLV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-specific component BioY of biotin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69940">
        <property type="protein sequence ID" value="GAE69940"/>
        <property type="gene ID" value="JCM18909_3210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="5814" checksum="414A3B58A5930939" modified="2014-03-19" version="1">MCVYLGGIFGLMGFAKLSLNAALTANLVLFGLDVVKGILACLIATAVLTAFPRLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX1</accession>
    <name>W4TLX1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2995</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69746">
        <property type="protein sequence ID" value="GAE69746"/>
        <property type="gene ID" value="JCM18909_2995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="151" mass="17040" checksum="7F0C019B06891834" modified="2014-03-19" version="1">MRDLVERHRGQPTLVIGQYVNQLEELAAELKCPIITGSTTPTRRQEIYQDFREGQIDLLVVSKVANFSIDLPSAEVAIQVSGAFGSRQEEAQRLGRLLRPKEGLVARFYAVVSRDTVDTDFASHRQRFLAEQGYSYRIIDADDLDALDRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ4</accession>
    <name>W4TLZ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase sigma-54 factor RpoN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69995">
        <property type="protein sequence ID" value="GAE69995"/>
        <property type="gene ID" value="JCM18909_3272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="2">
        <location>
            <begin position="58"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16416" checksum="F8C82F6C6D6D1F38" modified="2014-03-19" version="1">MYRILTNTYINSYRKAQRRPQTSDDQDVEDWQIAKAASHDSNGLRSAELEALDGLPDQQILDALDGLSDEFRQVVLLADVEGFAYKEIAEIMGTPIGTVMSRLNRARKQLRKQLVDVAGARGIGPRAGQVDEEDLGRSAMARRAGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM01</accession>
    <name>W4TM01_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70005">
        <property type="protein sequence ID" value="GAE70005"/>
        <property type="gene ID" value="JCM18909_3283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="22576" checksum="85B1003C3EB675E4" modified="2014-03-19" version="1">MALTYDDGPADTTAKIIDGFTHAKAAATFFFLLGTNVDNHPDTSTLLAGSGFEVGSHSASNRTLTTLGPRGRTAEITDAVNTLSKLTVRPTMLFRLPYGAHNEQVDTAMAKQNLAMVNWTADSNDWQNRDAGKITKTVTEYATTYTQPIIVLHDTYSSTADATSGLIEALRHKGMTLVTVSELTVNTGGLEAGKVYCRGTAVNQNGFGCHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM79</accession>
    <name>W4TM79_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter associated permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69637">
        <property type="protein sequence ID" value="GAE69637"/>
        <property type="gene ID" value="JCM18909_2877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11534" checksum="B8E4F3F7EB4738D1" modified="2014-03-19" version="1">MNTIVAGHVRDQTDAADAGKRLNYVVVDSTGRGSSGPINAAARRQMMGMDHVAKVYEWSQAGLLCDDDNGLPQIVWATAQIPDVPPARWPLTAPPGQCGQGKSSCQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB7</accession>
    <name>W4TMB7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69677">
        <property type="protein sequence ID" value="GAE69677"/>
        <property type="gene ID" value="JCM18909_2922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="8">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="9">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20640" checksum="37F6694D901D0094" modified="2014-03-19" version="1">MEVRDVHPSHYGRMCPIETPEGPNIGLIGSLASFARVNAFGFIETPYRKVVDGHVTDEVVYLTADEEDRHVIAQANAKLDDDGHFANDRVLVRQRHGEADEVPSSEVDYMDVSPRQMVSVASALIPFLEHDDASRASWVRICSVRPCRWCALRLHSSELVWNTAVRLTSVMSLLLRRPVRCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH0</accession>
    <name>W4TMH0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JCM18909_2851</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69613">
        <property type="protein sequence ID" value="GAE69613"/>
        <property type="gene ID" value="JCM18909_2851"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GAE69613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="301" mass="31588" checksum="85136C74CB26044D" modified="2014-03-19" version="1">MGIANTTPASALISVFTGLPPAEVTGRGAGSDDRRHQHKIGVVARALQVNRPEAKHPVEALAKVGGFEHAAMAGFILAAASSRIPVLIDGVIACSAALTATAICPEARDFIITSHAGAEPGITASTSALGLPALLDLGMRLGEGSGAILTLPIVQASAHILNEMATFEDAEVIDIKVSGETEIPDTVETSVPPCRMLVMGGARSGKSTFAESRLPRDSRVTYVATSQRNPGDAEWEERIRLHQARRPATCRLSRPLTSLQCCWPTTTPRCWSIALGCGSLGFLMRLAPGLPLLAMEPGRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR3</accession>
    <name>W4TMR3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69469">
        <property type="protein sequence ID" value="GAE69469"/>
        <property type="gene ID" value="JCM18909_2688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7072" checksum="0CC5B05CCA896FCA" modified="2014-03-19" version="1">MGMLVIDEAHCISDWGHDFRPDYRRIRNLVSALPVTIPVLATTATANSRVVQDVAEQIAPQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR6</accession>
    <name>W4TMR6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69713">
        <property type="protein sequence ID" value="GAE69713"/>
        <property type="gene ID" value="JCM18909_2962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic_M" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="19461" checksum="189A3E9830B3104C" modified="2014-03-19" version="1">MVRNVHPTILIGCSAQPGAFTEDIVKTMAAQCERPVIMPLSNPTRKAEALPSDVLTWTDGRALVATGSPFKPVMVNGVTYQIAQANNALVFPGIGLGTIAVRASRVTSGMIAAAAEAVAMHIDNRVVGASLLPSIKSLRPLSASVAIAVAQQAMEEGVATEVTDNPVEKVFSAMWQPRYPRIAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW6</accession>
    <name>W4TMW6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribose operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70061">
        <property type="protein sequence ID" value="GAE70061"/>
        <property type="gene ID" value="JCM18909_3346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9136" checksum="E2859108E4F5A38A" modified="2014-03-19" version="1">MGALRTCIDQGIRIGDEIDLVGFDDLPVFSLTNPALTVVAQDIDAMGKVAVDLLNRAMSGEPTSSAHLDTHLIVRASTRMVKENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX5</accession>
    <name>W4TMX5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70071">
        <property type="protein sequence ID" value="GAE70071"/>
        <property type="gene ID" value="JCM18909_3356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="10085" checksum="B6D1B1118B18C02F" modified="2014-03-19" version="1">MKADYTDQVVRPVLGEWVDESMATTRGPSVLLLFILQPFQKNNCYDEAVFVITFVFRKKSRPSVIYTARHHNRHKRILRRSMMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN50</accession>
    <name>W4TN50_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69634">
        <property type="protein sequence ID" value="GAE69634"/>
        <property type="gene ID" value="JCM18909_2874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15208" checksum="55D3DC00DAB3F9BD" modified="2014-03-19" version="1">MRREIGLSNDGLCLTPWKVKTTSSEEARWAMQALASADLFSNAKDAEKWGWESISDGYLRHLETYSGPSTTIAMALSAANTVSTLSRSQLQRIGDSLADAPCPRKDLGPALIRNGKPVKDKCSIESAYLLRYSGNLGVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA0</accession>
    <name>W4TNA0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70216">
        <property type="protein sequence ID" value="GAE70216"/>
        <property type="gene ID" value="JCM18909_3514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19724" checksum="884BFD58CC7452E6" modified="2014-03-19" version="1">MVTPLITKADGTKYGKTESGTVWVDPELTSAYAFHQFFLNAEDSKVIEYLKIFSPRSREEIEDLARKTEEEPWRRAAQHCLADDLTDLVHGVEQRKAAELQPRPFSDVASCATSMSGRCSLCLTSSVPPITKVASTRQWLTRWLPLVWSTPSLRAGVLSPRVGLTSTMLKSLILISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL4</accession>
    <name>W4TNL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_3640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70326">
        <property type="protein sequence ID" value="GAE70326"/>
        <property type="gene ID" value="JCM18909_3640"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="125"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE70326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="470" mass="51753" checksum="F2C85BD2AAD377F4" modified="2014-03-19" version="1">MLEDKLGEDARVTILGHVQRGGRPSAYDRWASTWLGYHAVHEVLSTTPEAEGRVIGTGSNRIHRLPLVKAVADTKSVPGLITEGRYNEAMRMRGRSFVEMDAIFTELSEPARTTSDTAGDADRQRVAIMHAGGPAPGMNTAARAAVRLAISRGHTVVGIHNGFIGLATGNMSELAWSDVEGWAGEGGAELGTRREIPSTRDLYAVSRALEDHHIDALLVIGGYSAYEGIYTMMTERDRYPAFRISTVCIPASIDNNLPGSELSIGTDTALNVIVEAMDKIKESGIASRRCFVVETMGRDCGYLALMSGIAASAERIYTNEDGISLDDLANDVHWLRESFAHGRRLFLAVRNENASHNYTTDFIARLLEEESHGMYDVRQVVLGHMQQGGSPSPFDRLLANRLGYRALNLIDDELAAHQDGSWFIGVNESGMRPCSMDTMPSLIDAAHRRPREQWWLQLRTIARMVSDEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV2</accession>
    <name>W4TNV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69884">
        <property type="protein sequence ID" value="GAE69884"/>
        <property type="gene ID" value="JCM18909_3149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="15665" checksum="65030C3824B80C65" modified="2014-03-19" version="1">MKEEDFTEVLDTNLTGAYRVIRRAARAMTRARFGRIVLTSSVVGLLGSPGQVNYSASKAGMLGMARSITRELGSRGITCNLVAPGFISTDMTEELPEKVVEGYLERIPAKRLGSVDDVVAAVRFLVSDSAGYVSGAVVPVDGGLGMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV8</accession>
    <name>W4TNV8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maltose/maltodextrin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70655">
        <property type="protein sequence ID" value="GAE70655"/>
        <property type="gene ID" value="JCM18909_4023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="16127" checksum="31B6151374584D46" modified="2014-03-19" version="1">MERKVPQGKKVSLIELSSEADQQRQSLINAAQTNSAAYDVIGLDLVWVAEFAANRWIVEIPSDTKPVGVIDSVWETGSYRGKQYAVPYTTDAPIMYYRKDFLEQAKVKIPKTWEDVKKRPPKPSASSLVCRTSAALVVNGPNTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX7</accession>
    <name>W4TNX7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adhesion or S-layer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70247">
        <property type="protein sequence ID" value="GAE70247"/>
        <property type="gene ID" value="JCM18909_3547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="200" mass="20607" checksum="53068D4DCD0B8A9B" modified="2014-03-19" version="1">MLSLLRRLLRWSDQSQQSSPQAEASSNRPRSVAQAAIATDGKGIINKDCRDAVINDAKLRAAIAGALVKAGFSSADAVALASRIAREMAKEGVLLINHHKLKALIGAQVGLLTDAKIQRAAAAVDLGIKATLAATIIPNALHSAAFKDAVVANLVAAGVDKKLTKATAVAIAATALNPALGPIAKTEAIKAEIGARQLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY7</accession>
    <name>W4TNY7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_4080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000070">
        <property type="protein sequence ID" value="GAE70700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70700">
        <property type="protein sequence ID" value="GAE70700"/>
        <property type="gene ID" value="JCM18909_4080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="153"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="381" mass="40984" checksum="0538357B4A5F20FB" modified="2014-03-19" version="1">MLKHTGDWLKNHHRQIADLAPKILKVALALAGVFSAIKLVNIATSLTTSILGLVATPVGQVMLAVGAVAAAIAGLVAALIYAYHHCREFHDRGTRWSTASCRPGVGRSGSSRCGCRRRRWRGRRSASPPLHPSLHRTLNPHHVEENDMQFIQAAHHSADPNLPPTRVVIHATCPDVGFPSASRAGRAVGTAGYLASTSASGSAHYVCDVTETVQCLGEDVIGWLAPPNGHSIGIEICADGGSRASFNNPSHAYSPEQWLSPQVWLAVEKAAHLTQQICHRYAIPVRRLTVADLKAGQRGICGHADVSAAWHQSDHDDPGPWFSWDQFIAAVRAGAERKVDNIPHTLLTSIHWGEAKHNLGGAADQDVGGPVMPRRQLEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPD6</accession>
    <name>W4TPD6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase with transcriptional repressor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70387">
        <property type="protein sequence ID" value="GAE70387"/>
        <property type="gene ID" value="JCM18909_3705"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="55"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="310" mass="34702" checksum="07AE417DCA978CBD" modified="2014-03-19" version="1">MTCALLEAGVPVYLEKPLAITLESATKVLVTAHQTGTKLYVGHNMRHMNVVRSMRDLIRTGRIGEVKAIWCRHFVGAGGDFYFKDWHATREHGTGLLLQKAAHDIDVMHWFAGSHTTDVVGMGGLTLYDQINDRRDHSDELMGDWYSLDNWPPLTQKGLNPVIDVEDLSMVLMRMESGVYASYQQCHYTPDYWRNYTVIGTEGRIENFGDGEGGVIRLWNTRTHYNAEGDETFPIIGDANGHGDADVLTVTEFLNFVRNGTRTDTSPLGAWYAVAAGIEATESLRNGSTPRMVPSLDAELVEYFNNNQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPI2</accession>
    <name>W4TPI2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70641">
        <property type="protein sequence ID" value="GAE70641"/>
        <property type="gene ID" value="JCM18909_4001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7302" checksum="DAE3F01D539D27E0" modified="2014-03-19" version="1">MAQAVTSSPTRCFDRVESGAGHEGRVGGWCSGLLWWESLFCWQISRLWWLGDRFVCWRVAVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPI8</accession>
    <name>W4TPI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alkyl hydroperoxide reductase protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70412">
        <property type="protein sequence ID" value="GAE70412"/>
        <property type="gene ID" value="JCM18909_3730"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008785">
        <property type="term" value="F:alkyl hydroperoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03026">
        <property type="entry name" value="AhpF_NTD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02974">
        <property type="entry name" value="AhpF_NTD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044141">
        <property type="entry name" value="AhpF_NTD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044142">
        <property type="entry name" value="AhpF_NTD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012081">
        <property type="entry name" value="Alkyl_hydroperoxide_Rdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03140">
        <property type="entry name" value="AhpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="7">
        <location>
            <begin position="131"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="219"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="402" mass="43095" checksum="3576FEAA6334CE65" modified="2014-03-19" version="1">MLDNALTTQLKTYLEMVREPIVLVPSPYRGDDAAKSSKSTHMDELLSEIAALSDKVSVGKPVDNERTPSFAITRPGSPIDIRFAGLPMGHEFTSLVLALLQVGGHPVKEEQQSLIDAVRAVKGEHHFVTYMSLTCQNCPTVVQALNAMAALNPNIHHTAVDGGTHTDEVEAKGIASVPAIYLDGEDWGSGRMDMAEILERLDADAARGAKEDLSQRDPYDVLVVGAGPAGAAAAVYAARKGIRTAMVGSRIGGQVLDTEAIDNLISVPHTTGPRLADALRSHVNDYNIDVIKRQTASALETTGGMTTVHLTDGDLRARSVIVATGAHWRNLGVPGEEEYRTKGVTYCPHCDGPLFTGKKRWPSSEVETPVLRPLSTLPASSTTSPSWSSLTSSKLTTYYYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPT9</accession>
    <name>W4TPT9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70244">
        <property type="protein sequence ID" value="GAE70244"/>
        <property type="gene ID" value="JCM18909_3542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17337" checksum="D1ABE1BB85721A07" modified="2014-03-19" version="1">MCHYVAGLLDEIGVGVTLHESEPGRVTLVAEWAPEGTDTSRPALLLHGHSDTVPFEAADWTHHPLSGEIHDNCVWGRGAIDMKGFLAMVLSAIRARQRRGEVPSRPIRFIMFADEECSGTLGSTWLGATHPEAFDGVTEAISEVGGFSLTTPQGKRVYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPW9</accession>
    <name>W4TPW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium-dependent transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70279">
        <property type="protein sequence ID" value="GAE70279"/>
        <property type="gene ID" value="JCM18909_3586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="PTHR11616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="25612" checksum="08BB07B2986079FE" modified="2014-03-19" version="1">MATVSGKPVSEVAGSGIGLAFIAFPQIISQAGAVGPVLGVLFFVSLVFAGITSMISLLEVVIAAFREKTGISRKAATWIIGGVTAIASIVLFPTTTGLNLLDVTDHFINNIGIVGVALLACLVISWALRKLPVLRDHLNEYSSFQVNKVWMALVSVVAPLVLLSLWITEIITVASKGYGEMPRNFVGIFGWGMSILVVVLAIVLSLIPWPHRSVIHHELTHEEELASENFQETEEGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ10</accession>
    <name>W4TQ10_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Citrate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70622">
        <property type="protein sequence ID" value="GAE70622"/>
        <property type="gene ID" value="JCM18909_3977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6156" checksum="6B23B0F7346A61DC" modified="2014-03-19" version="1">MNMFTVLFALGRLPGWIAQYREQVASGGNKIWRPRQIFTGSDKRDYVPLDKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ14</accession>
    <name>W4TQ14_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70473">
        <property type="protein sequence ID" value="GAE70473"/>
        <property type="gene ID" value="JCM18909_3800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6544" checksum="4044887822A9A04F" modified="2014-03-19" version="1">MLLDIGLPQLKCSCSAENMTCGHATVNVLRAVGPGLGAWHRAPIRMPVLGEEVVMASTLRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQP3</accession>
    <name>W4TQP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70549">
        <property type="protein sequence ID" value="GAE70549"/>
        <property type="gene ID" value="JCM18909_3890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12478" checksum="0E940E43583AE9C7" modified="2014-03-19" version="1">MALGDAFTQLVQSKGWGRQVNLHLVLSRWPELVGPTNAEHSRPVKYQGTVLTVRTEATVWATSLRTIAPQLVAELNRRLGEGTVTRVVIEGPSAPSWKHGPRSVPGRGPRDTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQX9</accession>
    <name>W4TQX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70649">
        <property type="protein sequence ID" value="GAE70649"/>
        <property type="gene ID" value="JCM18909_4017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022062">
        <property type="entry name" value="DUF3618"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12277">
        <property type="entry name" value="DUF3618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10628" checksum="382E19C03ECC7483" modified="2014-03-19" version="1">MADSKSKAKDERTADEIRRDIAATRARLAAGVENLVEEVHPATLKREASDRARDFVQGEFDQSRARSKMRMAGACSGSRWPQECSLPASSASLCCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE97</accession>
    <name>W4TE97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS cellobiose-specific component IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67290">
        <property type="protein sequence ID" value="GAE67290"/>
        <property type="gene ID" value="JCM18909_336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003188">
        <property type="entry name" value="PTS_IIA_lac/cel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036542">
        <property type="entry name" value="PTS_IIA_lac/cel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02255">
        <property type="entry name" value="PTS_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46973">
        <property type="entry name" value="SSF46973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="4832" checksum="1E2E27430743593D" modified="2014-03-19" version="1">MIGADTQLKKAHDVQTELIARDLNGSLPMSLLLVDDDDVRTVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEA7</accession>
    <name>W4TEA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67300">
        <property type="protein sequence ID" value="GAE67300"/>
        <property type="gene ID" value="JCM18909_346"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7691" checksum="566FDA06B5F035BE" modified="2014-03-19" version="1">MSYQGSMTYHVVHSLAFNAGLCVHLRLLAGRDPHHICEAQFKALARALRIAIAPDPRNAGRVPSTKGALNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TET4</accession>
    <name>W4TET4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="12 15">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ruvC</name>
        <name evidence="16" type="ORF">JCM18909_352</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 15">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="12 15"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67306">
        <property type="protein sequence ID" value="GAE67306"/>
        <property type="gene ID" value="JCM18909_352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GAE67306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="18967" checksum="33283B86C4146549" modified="2014-03-19" version="1">MGVDPGLTRCGVGVVEGGLGSPLKLIAVGVIRTPADLDHAHRLLRIHDGLEEWRDHTRPDAIAVEKVFAQHNRNTVAGTAQAAGMAMMIAARHGLPVALHTPSEVKAAISGSGRADKARWVSWWHGCYGSRLLPSLLMLPTLSPWRSATCGVAGRLVALKPLWLRNDAVGVCPVLGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEX0</accession>
    <name>W4TEX0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67505">
        <property type="protein sequence ID" value="GAE67505"/>
        <property type="gene ID" value="JCM18909_568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6027" checksum="4E9FD54044182F59" modified="2014-03-19" version="1">MLVHVKVLSRDRIVGEGPTTDVLSHPRGECTRAVAGAATIPGPAIQRARRARAAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF01</accession>
    <name>W4TF01_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67102">
        <property type="protein sequence ID" value="GAE67102"/>
        <property type="gene ID" value="JCM18909_139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3418" evidence="1">
        <location>
            <begin position="36"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27894" checksum="0E0B4FA230A257C1" modified="2014-03-19" version="1">MDSSNTTIEFATRPRILRSAVVSAAWWLTTTPSSLFYDRRIPDGIVSGSHFDAWWRRVQDRHQLDLSIDDLVDSGSVDADAFPDHWKVGNLELPVRYVFEPGSGHDGVTVTIPLALLNQVPTAPFSWQVPGLRTELATELIRALPKRIRTQLVPAPDRARAALTWLEDHDADRHAPFTNELGRALRTLTGSSSTLMTGILPLSRPICGLVSTLLTPREDPSVRNPERMVRTNSRIPARTHCPLRGSRGPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF90</accession>
    <name>W4TF90_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YciO family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67197">
        <property type="protein sequence ID" value="GAE67197"/>
        <property type="gene ID" value="JCM18909_240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="20519" checksum="D27E0586308681D9" modified="2014-03-19" version="1">MYFAGSLRPLQRYDDEVSKYFPVHPENPQQRSLNQVVDILHHGGLIAYPTDTGYAFGARLGNKDAVDRIRKLRQLSDKHHFTLVMSQFAQVGQYVQMDNWVFRAVSAAVPGRYTFILNATRDVPKVMLHPRKKTVGVRVPEHVTALALLEALNEHCLLHPHPARSGHTYGRRLAGSRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFB5</accession>
    <name>W4TFB5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cardiolipin synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67660">
        <property type="protein sequence ID" value="GAE67660"/>
        <property type="gene ID" value="JCM18909_735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18967" checksum="A617DA903403A3F9" modified="2014-03-19" version="1">MTQGYLIPDDDVVAALHQAASRGVDVRIVIPAESNHVIADWLSRGYYDRLLHQGVRLFLYQGAMVHAKTCTIDGIWSTIGTANLDRLSLQGNYEVNVAITDSTVAQRMAEIFEIDMANCVELTLDEWQSRSHIAKLTEALLSPWRPFFLKFRLQRNKKIRNPLSEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFD7</accession>
    <name>W4TFD7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucose-1-phosphate adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67476">
        <property type="protein sequence ID" value="GAE67476"/>
        <property type="gene ID" value="JCM18909_538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="113" mass="11976" checksum="40251F62B22CA47E" modified="2014-03-19" version="1">MQEQAPGAKFVMRGSCDDTLVSAGCIISGTDIYRTVLGPRARIERWARVDESIVMNNVAIGSNATVHRAILDKSVIVPDGAQVGVDHDHDRARGFTVSPGGVTVVGKGITVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFP0</accession>
    <name>W4TFP0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67790">
        <property type="protein sequence ID" value="GAE67790"/>
        <property type="gene ID" value="JCM18909_873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="209"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="242"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="457" mass="48602" checksum="58A6FDF7E8ACC97C" modified="2014-03-19" version="1">MTLGECLGHFTAPLVKGMTTTLVMMVLAWMWSWQLGLALLLAIPTIYLLTIASRALKLRGEALTYPTEQELAARIVEFCESQPALRAAGRASGYQPLHDAQVASGRAARKDLWLGVLANFVSGLAAQGIAVTLIVLAANLGGSGRLSPVVAVAFVGVSLRYTKVLEDVCAATLAIETAREPVAEVDEILSATVLPEPDIPVGLPAPGEVSFEGVSFGYDPARPVLHDVSFTVPAGGLMAIVGPSGAGKSTLFRLIARFWDANSGTVRVGGVDVRDQTTEQLMSQLAMVFQDVYLYDSTLTENIRIGCPDATDEHVRQAGALAGVDEIADRLPGGWDASVGEGGRRLSGGERQRVSVARALLKRAPILLFDEATLALDPENEAHVEAAVTQLRQTSTIVVIAHKLDTIRSADQIVVVDRTGKVCQVGTHDDLIASSGLYADLWHARERAVGWSLVGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFP1</accession>
    <name>W4TFP1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67253">
        <property type="protein sequence ID" value="GAE67253"/>
        <property type="gene ID" value="JCM18909_298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7245" checksum="C3B9D3D7A0855277" modified="2014-03-19" version="1">MSADRATRHYQYGGSPANWAGSIVALIGFIVATVGAMAGPNWTTCIMGAALVVLGGVVTLVMRAMGYGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFR6</accession>
    <name>W4TFR6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67815">
        <property type="protein sequence ID" value="GAE67815"/>
        <property type="gene ID" value="JCM18909_900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="300" mass="32637" checksum="223D92B181752AF4" modified="2014-03-19" version="1">MSSTEAAPRHGSAHQSYPWGFVVPAFAVLAVFFLTPTIYNFIYAFTDWSSFKTTINPVGWSNFSDLIASGSLRKSLIITLIYAAGVAALQNLFGLMLAVLLERDTLVNKIVRVIFFIPVILSALATGYIFQALLRPDGGLNQMLGILTGSPVKVSWLGSTTWTLLVCIVIHSWKWMGMSMLVYLAGLKTIDAQVLKAARIDGASRWATFHQIRLPLIAPAVTFNVATALLGSMNSFDIVQATTGGGPGGSTELLNLFIFRTFGQGLYAQATTMSLVLFVAVVILAFPMIGMLRRREGRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS9</accession>
    <name>W4TFS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67382">
        <property type="protein sequence ID" value="GAE67382"/>
        <property type="gene ID" value="JCM18909_438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7521" checksum="0A6C15AC885945BB" modified="2014-03-19" version="1">MHVFYASGLAINVLWTVANSGKRAVGFKLCDGMDQPAELSAFKFARQRSKLAGTIRGSYFVIKGDYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT1</accession>
    <name>W4TFT1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66984">
        <property type="protein sequence ID" value="GAE66984"/>
        <property type="gene ID" value="JCM18909_13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE66984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="26919" checksum="641CAA1C067BDB4D" modified="2014-03-19" version="1">MTHDVMAASVAGTGLGVSTATAAGLSHLVVDAGVAQPVQGARSVRIRGERGDLRHTDAMTPAQVEALLRDGQALGAEASHDGLVCLGEVGVGNTTIATALACAMTGLDPDKAVGLGAGSDTAMVERKAEVIKAALTRTHTDPNDPERLLAALGGPEFAVLAGVCLGAAEAGSPLILDGLATSVAASSRPSSRRVSTAGSSLRRHRENRFIKLCWLCWAWKPHEVADARWRRRRSMFWGPDDSHRSAGSPYRRANLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT2</accession>
    <name>W4TFT2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67636">
        <property type="protein sequence ID" value="GAE67636"/>
        <property type="gene ID" value="JCM18909_709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9708" checksum="83A9B7D526E99ED1" modified="2014-03-19" version="1">MEIKDENHIHLKSTVGVSKSIASTSAGSLASEFSDCNNSKGSAGTGSDGTVKKFEDNNYIGCIIAGETTAADLDKDDGMQVTFDKKTRCLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ8</accession>
    <name>W4TFZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67895">
        <property type="protein sequence ID" value="GAE67895"/>
        <property type="gene ID" value="JCM18909_988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="147" mass="15840" checksum="136EC47604FB197F" modified="2014-03-19" version="1">MDVDGRRFQLSTVMWMLGAWVVLFLVLFVIQHLRLHAARKDLLDVGEGPALIVCSRGLLLRRALRCESEGPVATSMDEVRWDDVSAVKVGGSSIGSGPGLVVYADDGRQWEVPLSWLDSRLADIDAAISAASGGHVRVEQDGAGIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG03</accession>
    <name>W4TG03_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67900">
        <property type="protein sequence ID" value="GAE67900"/>
        <property type="gene ID" value="JCM18909_993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="385" mass="41911" checksum="940D09ADD7A9E184" modified="2014-03-19" version="1">MDDNQNRGTFFCAYVHNLAADGATYTVLATVVPLGEGYLSVRVTPQVPEMLQAAETVYQAGRDAEWIAGEQGCGAPERARRGLDAVKTALEQAGYPDYGTFMRKALVQEVSVRRRQHRACRGMVDETTLGQLSSQVNRARQLVETWLETFDGLSDLSSKAGRTARTLSKAMNESQRTADVITDSREATEASLRPLVTVLTLWSRMDAEIAPLVNGVVADLDTMATSADLTSFRLAVAHIQVESTRSFVSELWAEVDGWQRALPAIDDLSRAVEEAMSEANRRLDEVRDLADRAASRTQELADLMAMPTALLTSWQQMASQRELSAGVADLVPRVEEQIGASQAMAAELTDVVAGLHKLADASNEELDVSVLAEIRRLGAEVAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB9</accession>
    <name>W4TGB9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68000">
        <property type="protein sequence ID" value="GAE68000"/>
        <property type="gene ID" value="JCM18909_1105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10077" checksum="A8799B95FDCE4B45" modified="2014-03-19" version="1">MNSVVQSLTKGLIVPCQTLPGEPIHSESDGVTPLFATAAAQSGAVDICANSVRDIKTILSTGADIVAVGGTITRPAHICTHFIDAIRSRIPHTSLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI0</accession>
    <name>W4TGI0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67259">
        <property type="protein sequence ID" value="GAE67259"/>
        <property type="gene ID" value="JCM18909_304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12043" checksum="95A2BC2A5D6BC158" modified="2014-03-19" version="1">MRPAVIAGIIGGRLYHVITDHQLYFGPGRTWYHCFFIWQGGLGIWGAISLGGLAIWLYCRRKGIRFASVADSLAPGILAAQAIGRLGNWFNQELFLAARRACHGVLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW9</accession>
    <name>W4TGW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67777">
        <property type="protein sequence ID" value="GAE67777"/>
        <property type="gene ID" value="JCM18909_860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13080" checksum="13ED6E5C42AA43A0" modified="2014-03-19" version="1">MVAAIAHLRGYDLDDQRVRTAILATLMGQREVDSLIHEEKLPTTPMGIATAPVGDADLEKVVARNLVNVLMGQVAGKKLPVFVSKRVPVLGGGVGATADGFTTWSVARYARKQFPTRRPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH23</accession>
    <name>W4TH23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68270">
        <property type="protein sequence ID" value="GAE68270"/>
        <property type="gene ID" value="JCM18909_1394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17904" checksum="69F8D04B746EB99D" modified="2014-03-19" version="1">MSDREPVNLGYPYVESFHSDFSGTGGVDQTDRSTNIDEHTIEEMHQIASRYPDSRSALLPILHLVQSVDGRISPVGIETAAEVLGITTAQVSGVATFYTMYKKHPAGQHHIGVCTTALCASWVARRCLPVSRRSLALKRGRRPPTASSLLSGWSVMLPAISRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH46</accession>
    <name>W4TH46_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67753">
        <property type="protein sequence ID" value="GAE67753"/>
        <property type="gene ID" value="JCM18909_834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="11131" checksum="7669B9C46820577D" modified="2014-03-19" version="1">MLGTPPLSEVLLIDPSGWFTTGKELGLLTAARERRRIRLCYRRSGETSGQWLTADPYGLVNKAGSWYLVADVDGHPRMFNTSRIEERDPLTDVAVLRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH49</accession>
    <name>W4TH49_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-specific component YkoE of thiamin-regulated ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68295">
        <property type="protein sequence ID" value="GAE68295"/>
        <property type="gene ID" value="JCM18909_1423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7519" checksum="6C01D896F591E49A" modified="2014-03-19" version="1">MTNDKLTVRYRTIDIVTPVMIAVAFGVIFLGYGAVYSLLKPVTSVYLPLRASFLASGSCRHFLLAHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH66</accession>
    <name>W4TH66_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67773">
        <property type="protein sequence ID" value="GAE67773"/>
        <property type="gene ID" value="JCM18909_856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="3"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4709" checksum="5283FB4B095917E2" modified="2014-03-19" version="1">MPRWVTTMSLGFDHRLIDGEQGSTFLHDVAEILSDPASAMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH89</accession>
    <name>W4TH89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminopeptidase YpdF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68151">
        <property type="protein sequence ID" value="GAE68151"/>
        <property type="gene ID" value="JCM18909_1270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="204" mass="22243" checksum="D342234B6FBF8460" modified="2014-03-19" version="1">MAPEAQTAPAEDLRIRGVVLPDGEERELWVHDGVLVEGLLSGARTLADGCWIIPGLVDAHNHIGLDAHGAVGTETAEEQARTEAKTGTLLIRDAGSPSDTHWIDDRDDLPRVIRAGRHIARPKRYIRNYAAEVDPENLVAEVDRQARSGDGWVKLVGDWIDRDEGDLAPLWPADIAQAAIDRAHELGARVTAHCFFRGSSRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH98</accession>
    <name>W4TH98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68161">
        <property type="protein sequence ID" value="GAE68161"/>
        <property type="gene ID" value="JCM18909_1280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Succ_DH_flav_C" evidence="2">
        <location>
            <begin position="62"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14298" checksum="C0E0993F3445B49F" modified="2014-03-19" version="1">MQGLADGYWVLPNTITDYLADSPKFGMVDEKHPAAVEARQAVESRINKLLTINGTRTVDSIHKELGHIMWEYCGMERNEAGLIKAIGLIRNLRNEFWTNVKVTGVNEELNQTLERAGRSPISWSSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA7</accession>
    <name>W4THA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67524">
        <property type="protein sequence ID" value="GAE67524"/>
        <property type="gene ID" value="JCM18909_589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6318" checksum="80644793D32A49A1" modified="2014-03-19" version="1">MIYARRGRSQGHVQPHHRHTVIAIYGMFYPCPKLPPMTNRTGIKNGQDDLVTLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC2</accession>
    <name>W4THC2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyruvate, phosphate dikinase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Pyruvate, orthophosphate dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67833">
        <property type="protein sequence ID" value="GAE67833"/>
        <property type="gene ID" value="JCM18909_920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilizers_C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00032883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15406" checksum="890BFC0E67D30733" modified="2014-03-19" version="1">MIELPRAALVADRIAEVADFFSFGTNDLTQTTLGISRDDAENGFLTEYLRTKVLKDNPFASIDQEASASSLPGPLTRAARLIQSCLWGSAVSTVVIRTRSTSSTRRGSITCPARRSVYRSLGSLRLRLSSLSRRSDLPSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH9</accession>
    <name>W4THH9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67619">
        <property type="protein sequence ID" value="GAE67619"/>
        <property type="gene ID" value="JCM18909_692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11141" checksum="6662A3185C5DFB39" modified="2014-03-19" version="1">MGGNDMASTPRRRWAWVLLLVVASLVIVGVYRKAVPQEGSTAYGQAAEALGDLPVKGRAPMTGYSRDQFGPAWSDNSDPALTHPWGHNGCGTRDDAWLATSSGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ8</accession>
    <name>W4THQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68326">
        <property type="protein sequence ID" value="GAE68326"/>
        <property type="gene ID" value="JCM18909_1455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9548" checksum="C110998D385AF197" modified="2014-03-19" version="1">MIIDDVAFSYRRHHEVLHGVTIELAPGRTVLLGPNGAGKSTLFSLCSGSRTPTSGRIGLAGVAEASSRTLRRRVADEAERSSHARVHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT7</accession>
    <name>W4THT7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68082">
        <property type="protein sequence ID" value="GAE68082"/>
        <property type="gene ID" value="JCM18909_1195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="30773" checksum="E4CAE634CC1EB603" modified="2014-03-19" version="1">MNNNDFRHRWWLYLLLTITLLLVVLPFAWMVLGSIKPENELVRTQPTWWPHHPTLDNFHRLFSGQPWGKYLANSIVVSAAVTAGSLLFSSMLGYALARLNYPGKKLIFGAVMGCLMIPGLVMFIPQYVLIVNMGLANTLAALILPFLVQPFGAFLMRQFFLGIPRDLLEAGRIDGAGELTIFFPHLPSPRDPSLRHLGDPHLLRFMEQFPMALGRVLLPRHLHAARSPCSGLYRRRPDGLRLAYGRCNTGRATDPAGIPVLPAIHSRSLSHAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX4</accession>
    <name>W4THX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68122">
        <property type="protein sequence ID" value="GAE68122"/>
        <property type="gene ID" value="JCM18909_1239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="2">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_38C" evidence="1">
        <location>
            <begin position="107"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro38C2" evidence="3">
        <location>
            <begin position="367"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="457" mass="50503" checksum="0DF576B63D9FE5D4" modified="2014-03-19" version="1">MDYPGERLAEIWRTICLYQFHDILPGSAIAWVYREVVADHRRISDELTELIHHAQELLAEEGDEEIVFDSAPMARPWVSAVAMSGSKAPSITESVHAEENEEEFIVDNGLLRMTVDAHGLITHLVDTASGRDAIPAGQRGNLLQIHPDFPNMWDAWDIDPFYANNVTDLDDGQATMSRKDGSVTISVTRTFGHSSATQSLTVNPGDPRVKVHTHVDWHEQDSLLKLAWPVDVHTDHADYEIEMGHITRPTHTNTSWDAFRFEVHAHRWVYVSEPGFGVAIANSGTYGWNVSRHPKDNGGTWSVARASLLKGARFPDPRADEGEHDFFHTLHAGADLADAIRDGYAANLCVRRRQGSPVEPLVSVEGVAVEAVKLAEDGSGDVIIRLYEPYGRHVHTTMTLGFEATSAVEVDLLEDPLDGNPRAQVAPSVITADLADGTIGLSMRPFQVATLRLGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX6</accession>
    <name>W4THX6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhs-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68381">
        <property type="protein sequence ID" value="GAE68381"/>
        <property type="gene ID" value="JCM18909_1515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="2">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="322" mass="34428" checksum="6F5C37C7C66C4FA6" modified="2014-03-19" version="1">MKFDFAVATEFAAKLREAAGKITTFEGERGRAESMAAAEFQGFFSQVFRQNMRVCSTDATEFSAAFTQTAAEIEYLAGEARKENERRQQVRDYLASHANENWLQSFWDWCTGSDDAPIPKATPPASRWVKPPETRPRQANQGLRGPSGGCLERGSGEPGRWGPANSWSKSGVAARVGAGSTVRALLRELPVWIIDCGGLVWPVPAWMGLNDADVAWLEAVGRAFAAAGGSGSVILADVALEAGLRAAGVSVTRADIQVSSPTLSGIDPATGYIEDPVNSATGNFVLPETDVVFSGPSQGLAISRMYNSTLAAAYDEPRRVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI15</accession>
    <name>W4TI15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucitol operon activator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68073">
        <property type="protein sequence ID" value="GAE68073"/>
        <property type="gene ID" value="JCM18909_1185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009693">
        <property type="entry name" value="Glucitol_operon_activator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06923">
        <property type="entry name" value="GutM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="132" mass="14597" checksum="AB499B68CA156F70" modified="2014-03-19" version="1">MFWPVLATVAIIYVCNATLAMRQMRNFSTTYTLLRKRGKVAIGKQKNALSRGAIVMFLLDDSDRVVAGRRMNGITVLARFRDFPVFDGLPVEEIDLQVCELIGERGAPSPTPVTTSSQSGPARSRSSPRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI42</accession>
    <name>W4TI42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric-oxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68202">
        <property type="protein sequence ID" value="GAE68202"/>
        <property type="gene ID" value="JCM18909_1324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17603" checksum="84AE2AA17AEC47FA" modified="2014-03-19" version="1">MVHLWVEDFLELLTTVMVAYIFVMLGVVREKVALGVIYMDVILYSAGGVLGTMHHLYFSGTPSAHMAIGAFFSAAEVIPLTFLTVEAWGFMQLGARRESRSSTPFPHRWTVMFLVAVGFWNFVGAGVFGFLINLPIVSYYEIGTALTANHAHGAMMGVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI43</accession>
    <name>W4TI43_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4234 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68421">
        <property type="protein sequence ID" value="GAE68421"/>
        <property type="gene ID" value="JCM18909_1557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025328">
        <property type="entry name" value="DUF4234"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14018">
        <property type="entry name" value="DUF4234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4234" evidence="2">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6509" checksum="0A843EC87A14FA39" modified="2014-03-19" version="1">MGTLDTNRSLLKYILLGIITFGIYDVWVLARAGEDLNVIASRWDGRRTMNFFGSSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI68</accession>
    <name>W4TI68_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68451">
        <property type="protein sequence ID" value="GAE68451"/>
        <property type="gene ID" value="JCM18909_1589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="363" mass="39674" checksum="B9A124656C300555" modified="2014-03-19" version="1">MISDVPGIGSNAATLARSQARSDKVEADLAVHPDKWRILTGDRPTGSLHIGHYFGSLANRVRLQNKGIESFLAVADYQVIYDRDGVGDLQANVMSNVADYLAIGIDPTRTTIFTHSALPALNQLLLPFLSLVTDAELRRNPTVKDELATSERPMSGLMLTFPVHQAADILFCKANLVPVGRDQLPHIEQTRVIARRFDERYGRAEASKPVFPEPEALLSATPHVLGLDGTKMSKSKGNAIELGMTADQTAKLIKKAKTDADRHITWDPENRPEVSNLLLLTALCEHDDPATIAEEIGDGGSGTLKKRLTASLNDYFAPIRERRAELAADEGHLREVLRDGNAKAAAVADQTLAEVREAMKMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID6</accession>
    <name>W4TID6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68725">
        <property type="protein sequence ID" value="GAE68725"/>
        <property type="gene ID" value="JCM18909_1879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6656" checksum="F7EE8B50F468512E" modified="2014-03-19" version="1">MVVDHRFGLPTDADVLPGYGAVIPLIPLTAVHIGASAALAAAIAALVGIGQIIGDVPAGWLVTKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF1</accession>
    <name>W4TIF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68551">
        <property type="protein sequence ID" value="GAE68551"/>
        <property type="gene ID" value="JCM18909_1697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8863" checksum="6999B1A6414BA271" modified="2014-03-19" version="1">MLNNGPYLLGIDYGTESCRVAIFDLAGRPLTFAATPYKTTHPRPGWAEQDPEEWWKALQASCHCGCWDLPGSYRRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII8</accession>
    <name>W4TII8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68596">
        <property type="protein sequence ID" value="GAE68596"/>
        <property type="gene ID" value="JCM18909_1743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="21847" checksum="5D623E29A27325C4" modified="2014-03-19" version="1">MSTSAQAGEHGGEVVVSGTVDELLAGERSVTGAYLSGKRSIPLPATRRPRTGRELVVRGARENNLKGMDVTFPLGQLVVVTGVSGSGKSTLVNQILYTSLAHRIHGARTVPGKHETITGVEEIDKVIHVDQSPIGRTPRSNPATYTGVFDKIRALFAQTPEAKMRGYQPGRFSFNIKGGRCENCQGDGTIKIEMNFLPDVYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK0</accession>
    <name>W4TIK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68362">
        <property type="protein sequence ID" value="GAE68362"/>
        <property type="gene ID" value="JCM18909_1491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850769" evidence="2">
        <location>
            <begin position="28"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24112" checksum="AD84C1A9BE505FC1" modified="2014-03-19" version="1">MNRQIRAVSLLAGLMFLALMVNLTGSAMFRQARLNNDPHNVRVRDAEFSQNRGNILVGSRPIATTTSSNGKFAYQRVYPSGPKYAPITGYYSYYYGRSMLEQTQNAQLTGTSDAQWLSRITGTLSGHKPEGGSITTTINAKAQDAAWNGLKGKKGAVVALDYTTGAVLAMASSPSYDPNELASHHLNDTTRAWKNLVADPSSPLSNRATREIYPPAQHSNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS9</accession>
    <name>W4TIS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transport ATP-binding protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68333">
        <property type="protein sequence ID" value="GAE68333"/>
        <property type="gene ID" value="JCM18909_1462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14906" checksum="CD2EF2A144927394" modified="2014-03-19" version="1">MNTRTTQLLKTLLRDVPRGRWLLVLSTLLAACASGASVALMGVSAWLLSRAAEMPPVLYLEAAAVGVRFFGISRGVFRYAERLVGHDLALRMQGALRMRVYDRLSRTTLLGRRGVTCWYGLLPTSTRCWTWSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX0</accession>
    <name>W4TIX0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Serine/threonine phosphatase PPP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68368">
        <property type="protein sequence ID" value="GAE68368"/>
        <property type="gene ID" value="JCM18909_1497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="13947" checksum="90F64E4D80AB0970" modified="2014-03-19" version="1">MAFSLDIRCHSEIGLVRRNNQDSGYVSPRMLVVADGMGGAAAGDLASTVAVRHVAKADRRFSGEGSPARPQGEEMLTVLSGAVADANDELADLVAWDSSLEGWERPSVARCSLVPSLASFTSAIPVAICCVKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ62</accession>
    <name>W4TJ62_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CarD-like transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68985">
        <property type="protein sequence ID" value="GAE68985"/>
        <property type="gene ID" value="JCM18909_2163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7517" checksum="717011E29E844A65" modified="2014-03-19" version="1">MVVRVPASNLDLVGVRDVVDDEGLENVFEVLRKTNVEEPSNWSRRYKANLEKNSTLATFSKLRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ77</accession>
    <name>W4TJ77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Folate-dependent protein for Fe/S cluster synthesis/repair in oxidative stress</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69000">
        <property type="protein sequence ID" value="GAE69000"/>
        <property type="gene ID" value="JCM18909_2179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="313" mass="33381" checksum="ADC0DFFF261F4E0D" modified="2014-03-19" version="1">MSDPVLLTDGPDTGLVSHMRNPIAEQRLMVDGGGSVELSNREVLAISGVDRLGWLHSLTSQFLDGMEPGRTTTSLILSPTGHVEHVLHGVDDGQIFWAWTEPGRGADLAAWLDSMRFMMRVEVALCPDMTVRWFGHDVAVSDGVVLDSEVAGGHEVILPVGAEIPGDADPVGVLAWEALRIAAGIPRIGLDTDDRTIPNEIGLYGTHMDKGCYRGQETVARVYNLGRPPRRLTLLQFDGSRAELPEVGADIHAGGRRVGAMGSSANHGVDGPIGLALVRRGVDVGLELEVDGIAAGQQPLVDPEVGLHVRPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI2</accession>
    <name>W4TJI2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2',3'-cyclic-nucleotide 2'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69115">
        <property type="protein sequence ID" value="GAE69115"/>
        <property type="gene ID" value="JCM18909_2303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="269" mass="28743" checksum="3A4B773CB2A5176B" modified="2014-03-19" version="1">MSRVATIAKQVRAEQGTDSVVMLDNGDTIQGTPLTYLSAKQPEKLGHDEVMARAFNLVGYDAANIGNHEFNYGVKELLRYHNDLKAPLLCANVIDVKTGKPLTQGSLMLTKKNVAGHEVKVGIVAVTTPGSMVWDKANLVGKVDIADPVQTAARYSVRLRKDGADVVVVLIHAGLSEDQAVPVYHGLPENNATVLAKSVPEVDLVVIGHTHQTTPLRLLTASQDTRSSSLSPTTGSFGISSDDSAGLLRHQGHDPPRSDHGQAALHPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI5</accession>
    <name>W4TJI5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="12" type="ORF">JCM18909_1730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68583">
        <property type="protein sequence ID" value="GAE68583"/>
        <property type="gene ID" value="JCM18909_1730"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="356"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE68583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="402" mass="42290" checksum="65217EC507F735A0" modified="2014-03-19" version="1">MKSVEDLGDLRGKRVVIRCDFNVPLDGDKITDDGRIKAALPTLTQLHEAGARTTVLAHLGRPKGAVDPKYSLAPVAKRLGELMNLDVKLAEDVVGPSATKTSESLADGEIALVENVRFEKGETSKDEAERAELAQKYASFGEFYVSNGFGVVHRKQASVYDVAKLLPSAAGSLVAKEVEVLEGLTADPKRPFVVVLGGAKVADKLAVIDNLLKAADTLVIGGGMAYTFLKAKGLEVGDSLLDEDSIDACTKYLEQAKAAGKQILLPVDVRVVSDIDFEARTVGQIDVVPADEIPSDKMAVDIGPETEKAYANAIKGAKSVFWNGPMGVFEIKGLELGTKAVAQALTEVDGLSVVGGGDSASAVRTLGFADDQFGHISTGGGASLELMEGKELPGIAVLKENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJN0</accession>
    <name>W4TJN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate regulon sensor protein PhoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68981">
        <property type="protein sequence ID" value="GAE68981"/>
        <property type="gene ID" value="JCM18909_2159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="350" mass="37593" checksum="67642E71D3BFD4ED" modified="2014-03-19" version="1">MRTVGMILSAIIGAVVGAGLTILMSRVVESSRHPVDTLATDIEAIEVDSALARALDLTTEAAVIVGPHDEVLHTTLGARSMELVRGSRIADEALLKLVRTARREGRDIVDTMEMKRASTGADLILTVRAGPLDDHGNAIIAASDSSRHVRLAETRRDFVANVSHELKTPIGAVSILAEAIEGAADDPEAIRHFSQRLTAESSRLSALVTQIIDLSRLQADEPLLRAEPVAVADVIDEAVSRHREQAANREVSLVVRCDDDLWVLGDQSQLTEAVANLVHNAIVYSEPKARVAVSARRVRDVDTDVIAIAVADNGIGISEADQKTYFRTVLSGGLLPFQGKRWNRPGIVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJN3</accession>
    <name>W4TJN3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">JCM18909_2355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TJN3"/>
    <dbReference type="EnsemblBacteria" id="GAE69165">
        <property type="protein sequence ID" value="GAE69165"/>
        <property type="gene ID" value="JCM18909_2355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4373" checksum="58897B7EBBFEF0D8" modified="2014-03-19" version="1">MKVQPSVKKICDKCKVIRRHGRVMVICDNPRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW2</accession>
    <name>W4TJW2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc-binding alcohol dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69245">
        <property type="protein sequence ID" value="GAE69245"/>
        <property type="gene ID" value="JCM18909_2441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7740" checksum="5C5507527BA16B30" modified="2014-03-19" version="1">MTSESMFSRPQFATPDVAEQGRALASIADLVEKGQIRPTMTRHIEGLTAQHVREATAAVESGTMIGKVVITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY9</accession>
    <name>W4TJY9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69275">
        <property type="protein sequence ID" value="GAE69275"/>
        <property type="gene ID" value="JCM18909_2475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIP" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10851" checksum="5104237AFD79C3F8" modified="2014-03-19" version="1">MITPSPLTDRVTVVTAPRGPDGIVATVQGLDLPQNTHAFVHGEAAMVRPMRRHLRLERGLSRDRIHLSAYWFAGRDADGWRAIKQDFNRSMEAESGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA1</accession>
    <name>W4TKA1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III subunits gamma and tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68937">
        <property type="protein sequence ID" value="GAE68937"/>
        <property type="gene ID" value="JCM18909_2112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16701" checksum="B1EF94CEF6F9C769" modified="2014-03-19" version="1">MVTPQGFNALLKLVEEPPPHVKFIFATTEPEKVIGTIRSRTHHYPFRLVPPKVLVDYLAELCGKEGIDVDHAVLPLVVRAGGGSVRDSLSVLDQLLGGAADGHVSYEQAAALLGYTPEALLDEIVDAFAAEDAHQVFCHDRQGHRGRSGPSPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB7</accession>
    <name>W4TKB7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase/fructose-2,6-bisphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68594">
        <property type="protein sequence ID" value="GAE68594"/>
        <property type="gene ID" value="JCM18909_1741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="248" mass="26960" checksum="F323113B1CFB77FB" modified="2014-03-19" version="1">MHLLLIRHGQSENNAFAAQSVETYQQGRKPDPELTELGRRQAQALGKWIGSVSPRPTKLYASPMMRTIQTAEPVAEALDLPIIINDLIFERPGPVQIVDGVETGHPGSPRSALSAITDRAVFPESITEEGWREARIETASEAADRAGRIAKWIRDTHNDDECIAIVAHGAIGSMVLLHLIAPQLAAGLRNHSIGSEPHWIGLQNTATSMIELHPDGYEVHWINRVDHLIEAGMVHGAVAASTGNPGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC1</accession>
    <name>W4TKC1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68878">
        <property type="protein sequence ID" value="GAE68878"/>
        <property type="gene ID" value="JCM18909_2048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11699" checksum="814C2AE2F6CF4750" modified="2014-03-19" version="1">MIVPSVSSTRDAVSRLLASPQVVYLDHREAAAGRTCEWPSWFPEDCRQAVEAAGIHRPWQHQARFAELARAGRHAAICTATASGKKPWPICYRSWLRRHRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ4</accession>
    <name>W4TKJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68928">
        <property type="protein sequence ID" value="GAE68928"/>
        <property type="gene ID" value="JCM18909_2103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="5289" checksum="306A24F12FF73FF4" modified="2014-03-19" version="1">MTHEARHAAWADRVIFLRDGRLVDESQVVSDPMELLNDNPKRGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK2</accession>
    <name>W4TKK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribonuclease YcfH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69057">
        <property type="protein sequence ID" value="GAE69057"/>
        <property type="gene ID" value="JCM18909_2239"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21707" checksum="DEFB9CE4A671F347" modified="2014-03-19" version="1">MKRIDELASVGNHVRAIGETGIDHFGTTDADGQALQREVFAAHIAMAHAHDLTLAIHMRDARNGGEGGEPPSDRQAHDDVVDVLNSEGWPDRIIMHCYSGDADLARICLDHGAYLSFSGTITFNSAGPQRDALAIAPDNRILVETDAPFLTPAPRRGKRNGPYLLPHTARFIAKQRGWDELRVCQQLTDNAFAAYGGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK7</accession>
    <name>W4TKK7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68943">
        <property type="protein sequence ID" value="GAE68943"/>
        <property type="gene ID" value="JCM18909_2118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5909" checksum="31D874E31698D3A8" modified="2014-03-19" version="1">MRHKGVPAARKAARREESGKAITPEPAARKGFGYRVQPLDVSVIEAPLPIQLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP6</accession>
    <name>W4TKP6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <ecNumber evidence="4">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68988">
        <property type="protein sequence ID" value="GAE68988"/>
        <property type="gene ID" value="JCM18909_2167"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="8">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13531" checksum="7AFCC9A06B1EF7CF" modified="2014-03-19" version="1">MPMHVAGLSFPDETVGLAGHSDGDVACHAICDALLSATGLGDIGSIFGTVDPQWAGAAGVALLGHVVALVTGEGWTIQNVAVQVIGQRPRMAARRAEAEAAWHKPSGLRFRCRRRRPITWGLPDVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ4</accession>
    <name>W4TKQ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68739">
        <property type="protein sequence ID" value="GAE68739"/>
        <property type="gene ID" value="JCM18909_1894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12499" checksum="B7E14CF1B6BBBE64" modified="2014-03-19" version="1">MDDNRWPSEWQRGVLDLCVLHILADGPTYGYSIAARLTDAGFADVKGGTLYPLLKRLEGAGLVDVEWRPGEAGPGRKFYLINTAGRQRLMALTASWQRYSTTVTRLLDEGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV3</accession>
    <name>W4TKV3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68789">
        <property type="protein sequence ID" value="GAE68789"/>
        <property type="gene ID" value="JCM18909_1951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="244" mass="25938" checksum="D19F24B0C0FAB3B2" modified="2014-03-19" version="1">MKAPTTSEISHNSHGTKSVLVTGATRGIGRAIADDLGRDHHIIVGGRHQEAVDNVVSELPNASPFVVDLTDEEATAAAVSHLDCLNVLINSAGVSAASPGDIASQSRDEWRRVLEINVVAVADLTRLVLPLLRASHGDVIMINSGSGFLRTPANGGVYAASKYALRALTHALREEERGVVRVTSIHPGRVDTDMQVELQAQAGRPYNASEHLRPQSVAVTVRAALEASPDAMIEELSVRPVFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW6</accession>
    <name>W4TKW6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">S-ribosylhomocysteine lyase</fullName>
            <ecNumber evidence="4 14">4.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">AI-2 synthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">Autoinducer-2 production protein LuxS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">luxS</name>
        <name evidence="15" type="ORF">JCM18909_2830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17753"/>
            <dbReference type="ChEBI" id="CHEBI:29484"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="14">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the LuxS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.21" evidence="4 14"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69595">
        <property type="protein sequence ID" value="GAE69595"/>
        <property type="gene ID" value="JCM18909_2830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043768">
        <property type="term" value="F:S-ribosylhomocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00091">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037005">
        <property type="entry name" value="LuxS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003815">
        <property type="entry name" value="S-ribosylhomocysteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35799">
        <property type="entry name" value="PTHR35799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02664">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006160">
        <property type="entry name" value="AI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01487">
        <property type="entry name" value="LUXSPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE69595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16687" checksum="346F478D9E150E0B" modified="2014-03-19" version="1">MNVESFNLDHTKVAAPFVRVADVKHLPAGDTLTKYDVRFCQPNKEHLDMPAVHSLEHSFAECVRNHSDAVIDFGPMGCQTGFYLIMIGEPDVPGTCELVETTLRDILKLNTTPAANEVQCGWGTNHSLKAAQEAAHTMLNHRDEWEQVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX5</accession>
    <name>W4TKX5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division protein DivIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69088">
        <property type="protein sequence ID" value="GAE69088"/>
        <property type="gene ID" value="JCM18909_2272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="14358" checksum="BFB2A49BBC943C1F" modified="2014-03-19" version="1">MGAAVLLVLVMITPSLGIYFSQRSQISRTQDDEARTRASISTLQDEVKRWHDPDYVRAQARSQLGWVMPGETGYQVIGENGKVIGSTTSLDEKKIRRVKPALTLGGGERLRDQSRTLTIPLRPTPPRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX6</accession>
    <name>W4TKX6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69610">
        <property type="protein sequence ID" value="GAE69610"/>
        <property type="gene ID" value="JCM18909_2848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="276" mass="30941" checksum="1BDDD678C1851261" modified="2014-03-19" version="1">MIDDLGVKASVARPVQRVVSLVPSITEAIAMTCPHVLVGCTDYCIRPTHLEEIVGHEVVRVRGTKNPDRKAIIDLRPDLVVANQEENREHDVTLLREAGVAVWVTRIDTVEEAISSLTRLFEEGFGVRCPQWLEEAGREWREPCRDEVLSAVTAVWRDPWICVGKDTYISDVLRRVGIELVDLPGESRYPHVELTDIAAAHPDRVILPDEPYHFGPDDVSAFPGLDVRLVDGQKLAWYGPSMVGARRYLASALRLLTPHRRYVPQCSTSPRGDMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ9</accession>
    <name>W4TKZ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaminyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69118">
        <property type="protein sequence ID" value="GAE69118"/>
        <property type="gene ID" value="JCM18909_2306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6206" checksum="6715108484132314" modified="2014-03-19" version="1">MTHSLCSLEFNSHRPLYDWFLSHLPLDGPAPKQREFARLELTHTITSKRRSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL02</accession>
    <name>W4TL02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69123">
        <property type="protein sequence ID" value="GAE69123"/>
        <property type="gene ID" value="JCM18909_2311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="316" mass="33285" checksum="9A4CCCC2F7AA43AD" modified="2014-03-19" version="1">MAHGASLIRDLREVVSPGADLLAGVGAFLAPMAVIGFEPHMGGDTIMFIAANIGYMWGLALGIVSILLLWSQRGPNVDHGWVLWVAVVLSCVASIHHELNAPGIVGAIVAMALITPAGKWTTRWATALIVAAVGNAARMGMPGLWARRHRVGDPYPYPKSTGEIPKRVSFIVHSVSHSLSNYPVVFFAIMLSVIAMCLVVMKRGFHRRAIGILLALFCVASVGLAAASLRIITVLAQRKLVGDIRLYFSATGVLSGVCFGIVMVILVVLTVMVARLPGCGMVGVSTGAAFGYYALPSIQGSPGGRTSFLGLAVFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL10</accession>
    <name>W4TL10_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyrophosphate-energized proton pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2615</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69406">
        <property type="protein sequence ID" value="GAE69406"/>
        <property type="gene ID" value="JCM18909_2615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="398" mass="42281" checksum="2D5F1DB260AB5538" modified="2014-03-19" version="1">MDILSGLVAGNFSGFWLGIIIVASWAHPSSSRAPVQGLGDMGAMSEVKWAVFAFGLVAFGFLGMGAVTIAVDSYGPVTDNAQSVYELSTIEDIPNVSDELEKHYGFAPRWDIAKHILEAQDGAGNTFKATAKPVLIGTAVVGATTMIFSIIMMLTEGLSNAAEVNKLGLTHAPFLLGLITGGAVIYWFSGASMQAVTTGAYRAVEFIKNNMQLDQNATKASSKDSKKVVQICTEYAQKGMLNIFLGVFFAALGFAFVDPYFFIGYLISIAIFGLYQAIFMANAGGAWDNAKKIVEVDLDAKGTELHDASVVGDTVGDPFKDTSSVALNPVIKFTTLFGLLAVELAVSIGAGLLTYILAAMFILIACVFVYRSFYGMRIDSTKDPEEFGVVAKEAGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL15</accession>
    <name>W4TL15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-sulfur cluster regulator SufR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69411">
        <property type="protein sequence ID" value="GAE69411"/>
        <property type="gene ID" value="JCM18909_2621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7466" checksum="1F1577F1982FCF1C" modified="2014-03-19" version="1">MEVAKVFPQLCNVETQLFSELLGSHVQRLATIAHGDGVCTTHVPIDVEITRRALAEPSKSPSIRKDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL37</accession>
    <name>W4TL37_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exoenzymes regulatory protein AepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69441">
        <property type="protein sequence ID" value="GAE69441"/>
        <property type="gene ID" value="JCM18909_2656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="7893" checksum="81B340D6B154DD50" modified="2014-03-19" version="1">MTVERTGDRRPSWHPEQALTLSQAITASTRHVTQVVTGGPGDVIAVAHNPFDLSGDALAGLTSDLTVVGGEVTAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL92</accession>
    <name>W4TL92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68914">
        <property type="protein sequence ID" value="GAE68914"/>
        <property type="gene ID" value="JCM18909_2087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021144">
        <property type="entry name" value="UPF0597"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30501">
        <property type="entry name" value="PTHR30501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="240" mass="24474" checksum="8124E07808F28A59" modified="2014-03-19" version="1">MASDDLCTRMTAYTAAASDARMGGAPLPAMTNSGSGNQGIVATVPVTVAADYAGVDHERRVRALALSHAVALYAHAGLPVLSAFCAATTAAMGAAAGICLVLDGSYSAVERAVASMTGDVVGMVCDGAGCSCALKVSASANAAGRAALLSLAGRRVPGTNAGTRRRRRGDSRHRPAGNRRNETDRSGDPVADDGETDRLNHGTIGPASAGPMREVPRRDIAPSIHTWRLAGTATLRVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA2</accession>
    <name>W4TLA2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ThrE_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68924">
        <property type="protein sequence ID" value="GAE68924"/>
        <property type="gene ID" value="JCM18909_2099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="7">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="213" mass="22193" checksum="93289144177B4C0F" modified="2014-03-19" version="1">MPGYISPSLGFSTNPILQMVAAAVIAVTFGISSHAGYRTLAICAALGAAAWAGYLLGMQLTGSVSAASGLAAMVAGFIAGLGAKRWKVPQLGLVTIAIVPLMPGVMMYRALYMIVNAQNETGGTSNAGWTLFLEALLVGVALAVGGSFGALLARPFTLPKDLRSRLATLASWGAGQAVPRERRRRRSQPPADPRHPALNNTETDPTMTGTWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB9</accession>
    <name>W4TLB9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69322">
        <property type="protein sequence ID" value="GAE69322"/>
        <property type="gene ID" value="JCM18909_2524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12674" checksum="DBC30696BC8A68E9" modified="2014-03-19" version="1">MSVAERTAARPLDRQEMASRATSGVWLGAVAAVLVMRLPMGFFLFLIVPWVILAVQTRFASSLRVTPLVAVEVCCMVASGMAVALFPSRTPNRHREQRLHHARGYRCDPRGVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG3</accession>
    <name>W4TLG3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Myosin-crossreactive antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69357">
        <property type="protein sequence ID" value="GAE69357"/>
        <property type="gene ID" value="JCM18909_2565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6765" checksum="432C064D95D873C6" modified="2014-03-19" version="1">MMAVYGLLDLDRDIPPIWPTQYDIRSLLASAKTLNNGRLPGSWLLSKLLKNTYYEDILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH7</accession>
    <name>W4TLH7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative phenylalanine aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pat</name>
        <name evidence="5" type="ORF">JCM18909_3091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the transamination reaction in phenylalanine biosynthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69835">
        <property type="protein sequence ID" value="GAE69835"/>
        <property type="gene ID" value="JCM18909_3091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01513">
        <property type="entry name" value="Phe_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024892">
        <property type="entry name" value="Pat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="28"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="356" mass="38922" checksum="3D66235F047B20F4" modified="2014-03-19" version="1">MEDDVSQDRRDVVRGLPLYKQGASHGENAVKLSSNENPFEPLPSVVEAVTRTLPRFNRYPSMSAEEVRSTIAGHFGVDVSQVAVGAGSTEVASQLMHALAGAGDEIIFPWRSFEAYPILTKVAGATPIPVPLTVDLRHDLDAMADAITDRTRVIFLCTPNNPTGTVLHTDEVVEFLARVPENVVVVMDEAYCHFNRDDAAVDGLTLLEDHPNVVVLRTFSKAYGLAGLRIGFAISTPEISDDLRRVATPFTVTTLAQQAAIASLAAEDELNERVNRIVAERTRVFDELTRQGWKIVPSQANFLWLATGDDTDRIDEVMVSHGVFARCWSEEGIRLSIGLDAENDRAIEALSQAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ7</accession>
    <name>W4TLJ7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69387">
        <property type="protein sequence ID" value="GAE69387"/>
        <property type="gene ID" value="JCM18909_2596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon_1" evidence="8">
        <location>
            <begin position="37"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25418" checksum="1F69C8EE30BC8D5A" modified="2014-03-19" version="1">MKVGRRLAMKILNASKFVLGFGEGGQVCDITNPADLSMLAGLRQLIAEATEAFDKFNYTAALEVCEQFFWTFCDDYLELIKERAYDSEGADNAGALSARTALRLALDVMLRLFAPFLPFVTEEVWSWWKDGSVHTSSWPTADDVPATGDADLMSDVSAALVELRGVKSTHKVPMRTPILSARISAPASVIANLKAVESDLAKVSKTESLTFLAEGDELVLEAELGEPPAKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK2</accession>
    <name>W4TLK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69860">
        <property type="protein sequence ID" value="GAE69860"/>
        <property type="gene ID" value="JCM18909_3122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="5122" checksum="FB95E4B99D8D7AF9" modified="2014-03-19" version="1">MVLIAALVLAMILRGVRKSIFIVSVMVIAALCVILLSLHATSDLGLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT7</accession>
    <name>W4TLT7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69716">
        <property type="protein sequence ID" value="GAE69716"/>
        <property type="gene ID" value="JCM18909_2965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025447">
        <property type="entry name" value="DUF4192"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13830">
        <property type="entry name" value="DUF4192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="341" mass="36925" checksum="125838B5BD9A9810" modified="2014-03-19" version="1">MTALHSSTTDNRDPLTVRTVEEAVTLAPYLLGFQSTESLLMIAADDGAACQGFVARADLGGLESAPAMNAFAGRVGPLAGQGRTVVLAFSKDQDRGMATLASAVEAMKGMNIGDVAWTDGEYWRSIFCDEQGCGENHRFVPDPTIAAEAVYRGLTVLPSRTSLVDKLSGPGRTCDPDTRRLLANSRRRLSRKDDNTVEVRCQALFESGDEINDAVVTELAVAVQRSDIARRLWMSMERADASRWLRIWSRAVEIIPDRMAPAPLSLCGLAGWLSGEGAVAAVCARRCEFMVGTADLPAALAVIVEAFVPPKLWDVMDHDPTVIAHPFFLEEQVDEEINLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM34</accession>
    <name>W4TM34_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69592">
        <property type="protein sequence ID" value="GAE69592"/>
        <property type="gene ID" value="JCM18909_2827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6197" checksum="CFD546941AB75842" modified="2014-03-19" version="1">MSSRTANDDDGARNVTHPFTPGWPLNWHCVRFHHPRIRRARRVVRLGSRDFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM81</accession>
    <name>W4TM81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine esterase cutinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70090">
        <property type="protein sequence ID" value="GAE70090"/>
        <property type="gene ID" value="JCM18909_3380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850812" evidence="2">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="18446" checksum="54BB7E0B671F21A9" modified="2014-03-19" version="1">MTDAVKVRQALLIFLVLCGLVSVPLSASAAPPSPIPTTTSTAYTSETPTSRPSVDVSPGAGMGWDSTPVSSDMAARMDCASVMFVGMRGSGETPPYGDTITSIRDALAQKWRGKGTVRQVYLNYPAADPHTLQNTPMSSLLFDSTMPSTEYFDSAALGAKKNSSPCLIPRKKAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC1</accession>
    <name>W4TMC1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Ts</fullName>
            <shortName evidence="4">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tsf</name>
        <name evidence="6" type="ORF">JCM18909_3129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69866">
        <property type="protein sequence ID" value="GAE69866"/>
        <property type="gene ID" value="JCM18909_3129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="5">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="4">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="11797" checksum="2B616FBA35D0996E" modified="2014-03-19" version="1">MHIGSETDFVAKNEEFIAAAHEIAEAADKAGADSKDAANAAALADGTTVGDKLGELAAKIGEKIELANAAHFDGNATCTSTVVPRTCPRRSASWSSTRATTSRLSTAFACRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD8</accession>
    <name>W4TMD8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69881">
        <property type="protein sequence ID" value="GAE69881"/>
        <property type="gene ID" value="JCM18909_3146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6665" checksum="829BFBBD4CBF8CF1" modified="2014-03-19" version="1">MSAVAQLAGVGVRRGDRWILNNVDLDVSDGQRWVLVGPNGAGKTTLLQVLGAQLHPTVAGGDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF7</accession>
    <name>W4TMF7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69598">
        <property type="protein sequence ID" value="GAE69598"/>
        <property type="gene ID" value="JCM18909_2833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="5115" checksum="9A94EC6233910594" modified="2014-03-19" version="1">MDHFLPGLRFDVVVSKKFDDLLGMLGAIVFFSRRRYPCSWPPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH3</accession>
    <name>W4TMH3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70185">
        <property type="protein sequence ID" value="GAE70185"/>
        <property type="gene ID" value="JCM18909_3483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18364" checksum="FE60F556713E5646" modified="2014-03-19" version="1">MASTATLRTNHGDIVLNLFADQAPKTVDNFVGLAGGTKEYVDPHTGQPTTGKFYDGLTFHRVIDGFMIQGGCPLGTGTGGPGYRFADEFHPELTFSKPYLLAMANAGPGTNGSQFFITVAPTPHLNRRHTIFGEVADEESRKVVDEIAQVRTGRMDRPVEPVVIESVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ2</accession>
    <name>W4TMJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type multidrug transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69404">
        <property type="protein sequence ID" value="GAE69404"/>
        <property type="gene ID" value="JCM18909_2613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="26"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16310" checksum="D1A032A9DA332B60" modified="2014-03-19" version="1">MTTLDLHPAPQAAPAAARVRNHALTEVRLVMRNGEQLLLALVIPIGIIVAGRFLGGRVGLTMDVLAPSVLALAIWSTCFTSQAIMTGFERRYGVLERLSATPLGRSGLLAGKAMAYSVISLAQVILLVIVSLALGWHPHGSGLAWLPTLVSVALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ4</accession>
    <name>W4TMJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70210">
        <property type="protein sequence ID" value="GAE70210"/>
        <property type="gene ID" value="JCM18909_3508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="8968" checksum="362B4F150E3D344E" modified="2014-03-19" version="1">MFVGQASGYFYVYYGSRVIPKKGAGGPNGGLSHVARAPMSGKMAPGTWHKWFGGAWSQPGIGGRESNLVPVTPDAPLGYTPVDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK8</accession>
    <name>W4TMK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA binding methyltransferase FtsJ like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69936">
        <property type="protein sequence ID" value="GAE69936"/>
        <property type="gene ID" value="JCM18909_3205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16706" checksum="E3252D17B485345A" modified="2014-03-19" version="1">MAEDLLRRRMRLVPMDAPRSWRWQSVPVRLDQALVEAGLARSRTLATRLVREGRVTVNRVVVTKPAMKVSTADVLVADEEVWVSRAAHKLLGTLDILGVHVPSRVLDAGASTGGFTQVVLSRGAKLVHAVDVGHDQMSPVLRNDPRVIVHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMV7</accession>
    <name>W4TMV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69748">
        <property type="protein sequence ID" value="GAE69748"/>
        <property type="gene ID" value="JCM18909_2999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5659" checksum="DD5A0CBBC0C15FC8" modified="2014-03-19" version="1">MSAHAYWEYIQFQGRPVTVFTTVTGAASSGSVATIVRVDLASHDIGWVYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN44</accession>
    <name>W4TN44_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane component BioN of energizing module of biotin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69937">
        <property type="protein sequence ID" value="GAE69937"/>
        <property type="gene ID" value="JCM18909_3207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23462" checksum="457409223C9A0329" modified="2014-03-19" version="1">MKTDASAFFGGYRAGNSPAHRMPVWSKYLLVLLVGVTPFFSSNSGGFPWAAWWWPSSSTWLLPRSRCARRYLLVCRCGSRMLSYSRITVFFTMWQRGVIYVAGLLACLYIARLVTCTTDPGALMDAIVALARPLRPLGAKPEKFALTIALMWTTIPYLVGSIGQVREAAKARGLERYSWRFLIPMFVGAVGHALEIGEALKARGLGDEEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN79</accession>
    <name>W4TN79_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70191">
        <property type="protein sequence ID" value="GAE70191"/>
        <property type="gene ID" value="JCM18909_3489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13236" checksum="CF58388E7DEF5EEC" modified="2014-03-19" version="1">MVRRMARDGRRWLLPGSVSSAFVSLVNIGVPLALGRAIDDGVVAADAAALTGWLALVALAYLVRAVAQTIRMQTNVGAGLAEHDLRVQALERITAPEGIGERSRLPGDLLAVIVTDVRAVSRASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB9</accession>
    <name>W4TNB9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70445">
        <property type="protein sequence ID" value="GAE70445"/>
        <property type="gene ID" value="JCM18909_3770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8064" checksum="D197AE4D2F88670E" modified="2014-03-19" version="1">MADLAVSIEVRCAVGSSGWLVSGFDGLETRSVATCANTILLPMAFAYSTPVSNTGFGMPGMIATITGRHFIVPRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND7</accession>
    <name>W4TND7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sucrose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69729">
        <property type="protein sequence ID" value="GAE69729"/>
        <property type="gene ID" value="JCM18909_2978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8706" checksum="9B109AEECA6390BB" modified="2014-03-19" version="1">MCVLANRGVEVFRLDAIAFIWKKLGTNCQNLPEVHDITQSLRQAIRIVAPAVAFMADAIVGPDDLTGYFGRGRTGEKSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL6</accession>
    <name>W4TNL6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70132">
        <property type="protein sequence ID" value="GAE70132"/>
        <property type="gene ID" value="JCM18909_3428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17028" checksum="794F5AA1C46539D7" modified="2014-03-19" version="1">MVPESLREKVTAARQDGKSVKFLYTVPNHSNPSGISQSTERRREILAVADELDLLVVEDNPYGLLNLDGDPLPTLKSMDPDNVVYLGSFSKTFAPGFRIGWVLSPSFVRDKLVLAQESATLCLRFFFPVCCLELPGPLGLACPGGQLHQYVPHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN5</accession>
    <name>W4TNN5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70575">
        <property type="protein sequence ID" value="GAE70575"/>
        <property type="gene ID" value="JCM18909_3925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14352" checksum="50502F87DF0DB5CC" modified="2014-03-19" version="1">MARRRRGWIHAVCNSPTRRAPSLEWERILGADLADDTEQLSPTPPPVVEEPDDPACDIDRFYNPPHPVAATELAAGVLINIDGEWVTITESSVDSGQIIVDWESAGDDSGTLMLGTQEAMLARTPLDPLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN7</accession>
    <name>W4TNN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA double-strand break repair Rad50 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70346">
        <property type="protein sequence ID" value="GAE70346"/>
        <property type="gene ID" value="JCM18909_3660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13155" checksum="56429FB7191DD252" modified="2014-03-19" version="1">MEQRARSAKLLYQTLSAHLEHVRQSYVAPFTTQIDRIGRGVFGQDLHVEIDSTLSVVARQLNGSRLEWDQLSSGAREQLGLIVRLAAARLIDPDDGVPVILDDALVYSDPVRSGTSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR3</accession>
    <name>W4TNR3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70038">
        <property type="protein sequence ID" value="GAE70038"/>
        <property type="gene ID" value="JCM18909_3319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="38" mass="4226" checksum="D0EB8034BD7871CA" modified="2014-03-19" version="1">MRWIDVFCETGAFDPDQTLEILRAGKDAGLGLRSMQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT8</accession>
    <name>W4TNT8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69874">
        <property type="protein sequence ID" value="GAE69874"/>
        <property type="gene ID" value="JCM18909_3139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11256" checksum="20813AA9E8150ECC" modified="2014-03-19" version="1">MLWARLEDWAGGLDELRDHGFTVAAMALSGDSLSLDEFSADLRQNPRKVALLMGTEGAGLSAHWISQADVVVRIPMAGGVDSLNVAAAAAVACYELREVTRVSPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP13</accession>
    <name>W4TP13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome (Plasmid) partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69924">
        <property type="protein sequence ID" value="GAE69924"/>
        <property type="gene ID" value="JCM18909_3192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="52"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="305" mass="32942" checksum="54CE945DF4376368" modified="2014-03-19" version="1">MSETAPEPLSRVPGPGREAEEAAENSIGPTGRSLPDLTEPTPVLDGPKHAIVISMCNQKGGVGKTTTTINLGAGLAEYGRRVLLVDFDPQGSLSVGLGINPHTLENSIYTLLMTLRDDVHGVIQPTEIEGMDLLPANIDLSAAEVQLVSEVAREQTLKRVIDRIRGEYDMILIDCAPSLGLLTINALAASDYVIMPLECEFFALRGIALLTDTIEKVQDRLNPDLEVLGILGTMFDPRTLHAREVMERVVQAFGDVVFHTVIKRTIKFPETTVAGEPITSYASSSPGAQAYRDLAKEVLARCRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP98</accession>
    <name>W4TP98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70352">
        <property type="protein sequence ID" value="GAE70352"/>
        <property type="gene ID" value="JCM18909_3666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6499" checksum="93020E2FA0A2DDB4" modified="2014-03-19" version="1">MITLIAEEVERKAVVGSFPTSRTSANFMWASRSALGGQGRGLGNHLNGDAGRVNKKVLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPQ5</accession>
    <name>W4TPQ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70502">
        <property type="protein sequence ID" value="GAE70502"/>
        <property type="gene ID" value="JCM18909_3829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="19627" checksum="82598F7E2D9B84CD" modified="2014-03-19" version="1">MRRWHIPHRFITEREQIRIATAEVSVLILAIQGEWEWVCEALRQRVVTPESCRQARKSLTGRYSKTKVDAALADVCLAAWSIPELEMGRVLRATGITGHKPNHKVRVGDHYYYLDRAFEAEKVALEIDGRSVHGTIDGFEATMMRSAHLDRHGWKVLHVTPTVFRENRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ38</accession>
    <name>W4TQ38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70498">
        <property type="protein sequence ID" value="GAE70498"/>
        <property type="gene ID" value="JCM18909_3825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="195" mass="20670" checksum="32336E41E5274F19" modified="2014-03-19" version="1">MGINNLLSDIGLPGLGCKPVLTDSKPRVVIVGAGFGGLAAAEKTAEAGCDVTLIDRNPYTTFQPLLYQVATGGLNPGDATYRLRSFAAHNGPHTHFRRACVTGIDTENRIVEVDNGDPISYDYLVLSQASGPTSSEPLVPPKTRTPFTPVHPRCALATQSSPTLRISTPNVTRPSTSSLLAAARPAWKWPAPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ74</accession>
    <name>W4TQ74_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">JCM18909_4070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000067">
        <property type="protein sequence ID" value="GAE70692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70692">
        <property type="protein sequence ID" value="GAE70692"/>
        <property type="gene ID" value="JCM18909_4070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE70692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="12531" checksum="261B5D99D9E4DD9B" modified="2014-03-19" version="1">MTMLWVCLAGGLGAVARFLLDSRINSRFSAPVPLGTLVINVVGSLLLGLITAAALNHLGFSQNLKEPLGTGFCGGLTTFSTASVETARAAYGCRKRVGALHCMGMAIAGVLAAILGLALGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQB9</accession>
    <name>W4TQB9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="11" type="ORF">JCM18909_3732</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70414">
        <property type="protein sequence ID" value="GAE70414"/>
        <property type="gene ID" value="JCM18909_3732"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="10">
        <location>
            <begin position="11"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE70414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="288" mass="32406" checksum="6F0F4A89CF3FA904" modified="2014-03-19" version="1">MVTPHLDLPLLAEGKVRRLYRLPDQPGRLLMVATDRISAYDHVLTPDVPGKGAILTNMSLWWFDQLADIVDNHLVSVDVPAEVAGRAMIVEELDMFPVECVVRGYLTGSGWAEYQRNRAVCGIRLPEGLQNGSRLEEPIFTPAIKVPQGEHDENIDYLRLVELVGPDVAAQLDDLSLRVYQRAEEIARKRGILLADTKFEFGRRADGTIVLADEVLTPDSSRFWDAETWQPGKGADSFDKQYVRDWLTNESGWDRASDQEPPASRRRSSRPPVGVMRRLGTSDWRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDK6</accession>
    <name>W4TDK6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_61</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67030">
        <property type="protein sequence ID" value="GAE67030"/>
        <property type="gene ID" value="JCM18909_61"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="255" mass="28432" checksum="BE67891BA5606491" modified="2014-03-19" version="1">MDVSFIARGKTLIAIREHGLRLVGNTELTLDVPVTDNAAEIGQVDVVLLCTKTFHVAEAARTYLPSLMGPHTLVVTTQNGVIAPHELSAIIGPEHVAPGVCRQWVKIVEPGLIMDLGGPRMFEVSTIDDSPNTLVNELRKACRKGGLTSPDVENITTTLWVRMCSVVPPRSLWCSTRRLLRRPPWPLPRCLRSVYRRNCSGGPRSQRQDRRRLRREEPHIPCWAGSRVNNLLPARHPCWAPQRIRCSGRSCPPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE26</accession>
    <name>W4TE26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_56</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67026">
        <property type="protein sequence ID" value="GAE67026"/>
        <property type="gene ID" value="JCM18909_56"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoacyl_synth_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7164" checksum="3065C5BD594C587C" modified="2014-03-19" version="1">MSDVVITGFGTTTPLGPDAPTTWQGLLEGRNGVHTLDFDWIDDVPVKFAAPAIDDPATHLPVHRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE76</accession>
    <name>W4TE76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67270">
        <property type="protein sequence ID" value="GAE67270"/>
        <property type="gene ID" value="JCM18909_316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22426" checksum="03B4066243B63A49" modified="2014-03-19" version="1">MIDDIRRRTVLGASMTAIVTAPLADRTLRAFGSDTQGLTIHLIGAPATSRVEIRGLDGRIRRFSTRPEALSRVASVNVPSRRFAVRMDSGRWRWLVRGDANQVWIMCDGDHEDPATYRSALPVPSEGVRVVSGRYWISVDWLAKAAGWPLSRGAVPFDGLSSVPSDLLTVRRGGDVETFDTRRNLHARNFEEKFFSTTSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TES7</accession>
    <name>W4TES7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67455">
        <property type="protein sequence ID" value="GAE67455"/>
        <property type="gene ID" value="JCM18909_516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="102"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="425" mass="45427" checksum="0D2D1805D3E17EFE" modified="2014-03-19" version="1">MCPVEAIYYEDDLPGDQEKFLDINAEFFNELGSPGGAARLGPTHKDPPGRRSPAPTGRMSRRNVSASLPTFPWDTIAEARRKAQSHPDGIVDVSMGTPVDPTPRVAIAALTAAGDAHGYPQVWGTPALRAGILDHMKQVWGAPANLDEVSVLPVIGTKELVASLPGQLGLGSDSTIVIPACAYPTYRVGAQLAGAKVVAVNEPDEVDIAPDLIWINSPANPSGHVLDLDEMKAWVDLARSTGAVLASDECYGEFVWEGESVSVLDERVNSGDVTGLLACLSMSKRSNMAGYRAGFAVGDAELTSELLAVRKHSGLMIPAPVVAAMQAALADRSHVLEQVKRYRLRRNVLKPALEKAGFRIDHSEGSLYLWATHDEDCRVTLDRLADLGILCSPGDFYVAGGSDHVRIGLTATDERINAAAQRLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TES8</accession>
    <name>W4TES8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_65</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67032">
        <property type="protein sequence ID" value="GAE67032"/>
        <property type="gene ID" value="JCM18909_65"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11366" checksum="886D41B2EFDB9A44" modified="2014-03-19" version="1">MGFTFGFGSIVWVYAGEIFPARYRSLGASLVLTADLIANAITAQLGAAMLDGIGLAGTFGVYGGLLVVALLFLLRYAPETSGRSLEEIQDYWNNGARWPKADSPSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEW2</accession>
    <name>W4TEW2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67067">
        <property type="protein sequence ID" value="GAE67067"/>
        <property type="gene ID" value="JCM18909_102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="204" mass="23045" checksum="07AFF014328ED2E0" modified="2014-03-19" version="1">MLIALIAVSVLAVAAIIGSLADRRAIGRRAERAESERDVKALELSRSQERLSRASQDLADSRKDVAKARAELESSRTRASDEARRADHADQARRSAEALLEINRRSVEELTERDHRLQEARRHLEEGLDKIEQDRLELAERSSQLDERDAELDRRHGQIVTELERVAGMSLDEPAMSSLSIWDGSSRLRRKQCPCHRHRGDGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF31</accession>
    <name>W4TF31_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67132">
        <property type="protein sequence ID" value="GAE67132"/>
        <property type="gene ID" value="JCM18909_172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="358" mass="38535" checksum="B7ACB3EDACE799C6" modified="2014-03-19" version="1">MDSALSPREIQSRIRSGATVEEVAVEAGVGVDQVEPFAVPVLAELDHIIEVAMTCPVRRAGAPGSHRTLGTVISRVAKANSIPEATISWRSWRHEDRTWALEARWPASTEDAPHSAAFRFDLKGRHTSPEDAGARWLVNDRSPAPAEPLPEGASDPDQEPTLDLNDELAIVRAVSNRQSQTADPEAVAGMTKHDGVYDFDTSSPADTDMLYEMLAGFQEDSVNIYEGLATPVLDAASHPEVNQDTEPATPQVPQPAEAPHAIETSQPDQVGGKSEAQPPHDDTSAQDTAASKPRTSTKTSTSTSRSQASAQAADETPPQDALVEEGSRPRKKRKPRKSKRASIPSWDEIMFGGPTPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF40</accession>
    <name>W4TF40_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyruvate dehydrogenase E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_72</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67038">
        <property type="protein sequence ID" value="GAE67038"/>
        <property type="gene ID" value="JCM18909_72"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8498" checksum="DB73E4C2BB8FBB73" modified="2014-03-19" version="1">MPGDYASLGADGFGFSDTRAAARRFFHIDGPSMAVRALQMLVERGEVPEDWPAKLPRSTTFSTSTRGRPVTLVATPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF83</accession>
    <name>W4TF83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SOS-response repressor and protease LexA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67088">
        <property type="protein sequence ID" value="GAE67088"/>
        <property type="gene ID" value="JCM18909_123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13900" checksum="CD84E4EEDD4EE3E0" modified="2014-03-19" version="1">MITDTPGTDTSDPAAVSSAVPFTNTREPSAKERKVLAAVKEGLRRDGKAPTVRALAEMTGAASTSTVQRRISSLIDLGCYVEPMAPSRWPKKPSRPAIRTDRKPFKSNSSIRVTKNTMKPSSRCHPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFC6</accession>
    <name>W4TFC6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67670">
        <property type="protein sequence ID" value="GAE67670"/>
        <property type="gene ID" value="JCM18909_746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5452" checksum="8B69FFA220889FC0" modified="2014-03-19" version="1">MSIAGTSLIDEFVNTSGHPGGLVMFSVGNIPDDFVAITLISPQIFWRDDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFL3</accession>
    <name>W4TFL3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1,4-alpha-glucan (Glycogen) branching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67228">
        <property type="protein sequence ID" value="GAE67228"/>
        <property type="gene ID" value="JCM18909_273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-amylase_C" evidence="1">
        <location>
            <begin position="141"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="266" mass="30678" checksum="EA9704E8A4393A0F" modified="2014-03-19" version="1">MNDSLRYLELNPFHRQYHHGEMTFAMVYQYSENFILPISHDEVVHGKGSMITKIPGDDWQQFASLRAFYSYMWSFPGKQLVFMGQEFGQRHEFDESVSLEWFVADLWGHGGLKRLFRDLNKIYKENPALWQLDSDPRGFEWINADDAGNNLFSWLRRSDDGSTIACFTNFSPNPQTDYRIGLPMEGVWTEILNTDSLEYDGTGEFGNLGQIVATPLPAPDRFRAVAQCAFHRWDRCGYVTIRQQPLLCPAIRACNDRATGGIIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFQ6</accession>
    <name>W4TFQ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67611">
        <property type="protein sequence ID" value="GAE67611"/>
        <property type="gene ID" value="JCM18909_684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="246" mass="26839" checksum="76A11989CF9C9F19" modified="2014-03-19" version="1">MLSRRSPSDRSTAIVMEVSAGGGSIVVSGVSHNFSTTHNRNLVLDDVTVSMQPGVMTLLHGVSGSGKTTLLNIMSGLLKPTSGTVFVEGSDIYSLSTSERDDIRLNRIGMIFQEHSLIVDFTVRENVELILRVRGFGSRSRVMAIEALERVGIAHLQDRYPRQLSGGEAQRVGIARAIAGDRPILLADEPTGQLDRRNSQMVFELLRALAEDEKGRTVVLSSHDPTAKEYAHRSCELVDGHLEDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS1</accession>
    <name>W4TFS1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67820">
        <property type="protein sequence ID" value="GAE67820"/>
        <property type="gene ID" value="JCM18909_906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9346" checksum="06F6C34E3BDD1596" modified="2014-03-19" version="1">MVADHDRAIAADADIDLAGWTLLGVGDEFTDPTYSSAQWHRGLWYPHSGRGLFRDANVSFSGGQLHVAARAEQVDSFFLHVWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFU0</accession>
    <name>W4TFU0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67646">
        <property type="protein sequence ID" value="GAE67646"/>
        <property type="gene ID" value="JCM18909_720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="19778" checksum="B0E1FEC1A728F572" modified="2014-03-19" version="1">MVSDAHASTRLIGVALMVWAVPRLARYAGTDPDHALWLAVCCPLTTLSVVGGMHNDGLQVGLSLVALVVAIRLALIGRGWLGLVLGGAFVGLAGSVKQPGVLAGVGIVALVHVNAVRHGGRRWSTRNCWTALLARIAVGAIPALTVFGGISAIHGLGMGWLNSTAGSPVSVTSDSPIALVVQFFCEATEVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFU6</accession>
    <name>W4TFU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha,alpha-trehalose-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_28</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66999">
        <property type="protein sequence ID" value="GAE66999"/>
        <property type="gene ID" value="JCM18909_28"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE66999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="467" mass="52881" checksum="3626222AF617FE78" modified="2014-03-19" version="1">MSETVQDKVDFLVVANRLPVDRKVDDDGSVSWKSSPGGLVTALEPVMQRKGGAWIGWHGAPDEVVKPFHHDGYDIHPVPLSAQEIEEYYEGFSNATLWPLYHDCIVEPVFHREWWDAFQKVNKRFAEQAAEQAAEGATVWVQDYQLNLVPKYLREMRPDLRIGFFLHIPFPPIELYSRLPWREELVEGLLGADLIGFQTPGAAANFQRLARHRPGVTAARGRAHTPDGRTVVIRDFPISIDSRGFHELATSEKVKAEAAKLREDLGHPGTIIFGVDRLDYTKGLRQRIRAVGELFKEGKLDPHEVVFLQLATPSRERVEEYKILRDDINLLVGQINSKVGSIANRALVYRNESVPREVLAAMYQMADLMLVTPVRDGMNLVAKEYIACRSNDDSALVLSEFAGAARELKQAYMVNPYDIDGMKATIMKALTDSPKIKARKMRSMRRQVFDKTIDVWADDFLTELEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV2</accession>
    <name>W4TFV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67313">
        <property type="protein sequence ID" value="GAE67313"/>
        <property type="gene ID" value="JCM18909_360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="395" mass="43422" checksum="57BB4BDDA68EA22D" modified="2014-03-19" version="1">MSSNRPLWSSFHSKRLNLFLELVKRLAWSAVLLLISTLIVWVDRDSYVDSTAGDGVSLIDAFYYSTVTVTTTGYGDITPVAPHARLINALIITPLRITFLVLLVGTTLEMLANEGRRGLLDSAWSKRMRNHTVVIGYGTKGRSAVNTLRNHDIPVEKIVVIDSRPSAVAEANRSGLAAFEGDATRRDLLRRAEISKAREVVITLNRDDSAILTTLTVRQLNPRCHIVVSGREDENLPLLRESGADAVVTSADAVGRLLGLSSVNPHVGTVVDDLLSSSKGMEVVQRMVSESEVGARPADIQNERVLAVIRNDVLRNFYDPRWVSCRPVTSSWSCAKRFHVAMNHKLKATWCAENSARGLTLLSALVAPSSGSTLNDTETRHTTRMRGLACQEVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG00</accession>
    <name>W4TG00_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosine/purine/uracil/thiamine/allantoin permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67437">
        <property type="protein sequence ID" value="GAE67437"/>
        <property type="gene ID" value="JCM18909_498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7670" checksum="0758FC2B3E120181" modified="2014-03-19" version="1">MTVIGWGLVVNTYEGVNWNNWQGFLLGPIGLGGREGDWAHANLGVFGALVLGYVVTLIARRGTVRRQESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG14</accession>
    <name>W4TG14_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="5">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="5">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="5">IPP transferase</shortName>
            <shortName evidence="5">IPPT</shortName>
            <shortName evidence="5">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">miaA</name>
        <name evidence="9" type="ORF">JCM18909_114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5 7">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5 6">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67079">
        <property type="protein sequence ID" value="GAE67079"/>
        <property type="gene ID" value="JCM18909_114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="320" mass="35996" checksum="92D05D8DBE8FF925" modified="2014-03-19" version="1">MRKKNEYVNLPVICLVGPTASGKSGLAVRVCRRLYVDEHPAEIINTDSMVVYRGMDIGTATPTLREQRTVVHHLVSILDVTVPSSLVLMQTLARDAVEDCLSRGVIPVLVGGSALYTKAIIDEMSIPPTDPEVRARWQEKLDAEGPQVLHDELARRDPEAAESILPGNGRRIVRALEVIDLTGSFTATIPDGTLHWPKTVQMGLELPRKDIDQRIADRVDQMWADGFVDEVRSLANVGLREGLTASRALGYRQVLEYLNGDYDEDEARRRTIIGTRRFARKQLMWYRRDDRIEWFNALAPDLDDRVVARVLTALTTDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG63</accession>
    <name>W4TG63_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane component BL0694 of energizing module of predicted ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67781">
        <property type="protein sequence ID" value="GAE67781"/>
        <property type="gene ID" value="JCM18909_864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="186" mass="20527" checksum="00DC5A77198606CF" modified="2014-03-19" version="1">MMTSLGVVWVFLVLTTRSKSWISWTIFVLVWIFCCFLLPVLWRSTVSAFLVFIAFWMFRFAGVFGAAVAAIKVLDVTRVGAVLTQLHAPRVIYVPVMVVVRFFPMAVRELRAIVQAMTLRGLNPGARSAVRHPIRTGEYVVIPFLASAARIVDELSAAAIIKGLGAQKNPDRTPSRVVFASATPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG83</accession>
    <name>W4TG83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic protein kinase ArgK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67418">
        <property type="protein sequence ID" value="GAE67418"/>
        <property type="gene ID" value="JCM18909_477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23408">
        <property type="entry name" value="PTHR23408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="344" mass="36740" checksum="C3DB175ED3FC62D3" modified="2014-03-19" version="1">MIMPIDVPELVEQVLAGSRQHIARALTLVESSKPAHREKAREMLRQLAPRTGDAIRVGISGVPGAGKSTFINAVGGKLIDEFGYKVAVLAVDPSSTRTGGSILGDRTRMGDLANRDEAFVRPSPSGGHLGGVARATRESMIVMEAAGYNVVLVETVGVGQSEVAVAGMVDTFLMLSVAGTGDQLQGIKKGILELADVVAVNKADGDNAGNARVSARDLSIAMKLVSSDADKRRVPVLTCSSYTKEGLDDVWQAIVDHRAYLEKDGSLQIRRTEQQREWLWNMVRNEILESLDTDPSVQQTAERIEAGLGIEATSALEGAEEILRAFARAVPNLPWAQGELTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH8</accession>
    <name>W4TGH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Substrate binding component of glycine/betaine transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67886">
        <property type="protein sequence ID" value="GAE67886"/>
        <property type="gene ID" value="JCM18909_978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850719" evidence="3">
        <location>
            <begin position="30"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="4">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="21205" checksum="35F34EC5B2D706AF" modified="2014-03-19" version="1">MMSHGVAAMAFLAGLIGLGLAGCSGTAGVYNSGDEAANGSRSGVEATPEAHAGATPDQKWTHCTPGARSKDITAMTPDTNTSLTIGAFNGWDESWATAGLIKQVLKKDGYTVTIKGFDAGVGYQATAGGDIDIITDSWLPVTQAGYIRKYGPKLENLGCWYDNAKLTIAVNKKTRRHIPSPISRKLAAPTETSFTASNRVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ5</accession>
    <name>W4TGJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68080">
        <property type="protein sequence ID" value="GAE68080"/>
        <property type="gene ID" value="JCM18909_1192"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="230" mass="25470" checksum="AD017D4647E59198" modified="2014-03-19" version="1">MPFVKQRALSPRTAIRDHVLAALDYIEAHRTRDPRLPAYGHGDWNDSLQPTSASLAEQMCSTWTTELEIHSLETLANALGPVYPDLSKRLRSRAAATREGLTDVFLADGELAGYAIIGNPTMELMVHPRDERTGLHHGILQMIHAISGELLDPLDMKHHLDIIAEYLTGPMAHTYSTRPSPIQAARRTTSNELRQPLSGDEKSASCTPTPIYALLKLSHMLAEPSRHGMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL0</accession>
    <name>W4TGL0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyribonucleotide nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68100">
        <property type="protein sequence ID" value="GAE68100"/>
        <property type="gene ID" value="JCM18909_1214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21103" checksum="989161B8D29E73AD" modified="2014-03-19" version="1">MLPTREEFPYAIREVSEAIGSNGSTSMGSVCASTLALLNAGVPLRASVAGIAMGLMSETDEDGKTKYLALTDILGAEDALGDMDFKVAGTSEFVTALQLDTKLDGIPADVLAGALKQAKEARTAILEVMNEAIDSPDEMAPTAPRIITVRIPADKIGEVIGPKGKMINQIQDDTGANISIEDDGTIFIGLITEIRPSLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR0</accession>
    <name>W4TGR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SSU ribosomal protein S16p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68155">
        <property type="protein sequence ID" value="GAE68155"/>
        <property type="gene ID" value="JCM18909_1274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="7924" checksum="740DA5E192063584" modified="2014-03-19" version="1">MLKRTGDWQKFTGDTSPSGVKPQPERPNKDDLFNAALAEADEAPREAITKKFEGAAADEASESAAGDNSGEKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH04</accession>
    <name>W4TH04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68250">
        <property type="protein sequence ID" value="GAE68250"/>
        <property type="gene ID" value="JCM18909_1373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="30"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="21908" checksum="FB4BB7E815898FF1" modified="2014-03-19" version="1">MSLNSASFNGARLLGPGLGGLLIAAVGVGWVMAINVVCFIGFISTLLLIKADRLYTSPPASEKARVRDGIRYVKRRPDLVILLTIGFMMGTFGFNFNISDAVMATQAFGKGSGEYGLLGSLMGIGSMAAALGAARRKPRLRWVELALLVYTISMGLSALAPNYGTFAVLKMFVGWGAISTLITANVMVQTSVTPHMRGRVMSCGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH48</accession>
    <name>W4TH48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xanthine-guanine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67449">
        <property type="protein sequence ID" value="GAE67449"/>
        <property type="gene ID" value="JCM18909_510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="13"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15175" checksum="1AC91AE06404D58E" modified="2014-03-19" version="1">MTAYHADASDLEGKEILTWETFGDATAELAAQIHHSGFDPEILIAVARGGMIPGGALTYSLGVKLTDAINVEFYTDVQETLPDPVLLAPMLDTESIRNKRILIVDDVVDSGRTLAWYSSCCAASKRRPLGGALRQAHDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH51</accession>
    <name>W4TH51_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68111">
        <property type="protein sequence ID" value="GAE68111"/>
        <property type="gene ID" value="JCM18909_1227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="133" mass="15164" checksum="49FF80FEE13E1ABA" modified="2014-03-19" version="1">MTRWRTRTQKELHRPLAEAVGAKTAKAFSALHVDTVGEALGHLPRRYLTGTETTDLSHLVIDTEVALVADVVGVEVHINKTVTGRERRPRQRLEVMLSDGKARLPVTFFGKPHIVSYWQRIFFRPILTAFFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC1</accession>
    <name>W4THC1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67544">
        <property type="protein sequence ID" value="GAE67544"/>
        <property type="gene ID" value="JCM18909_611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="5875" checksum="197106E547F90D77" modified="2014-03-19" version="1">MVVLTDAQAHLDVLDTPGLLATATREGRLPPVIAVFLSTLGPTGLNNSVSPGARRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC7</accession>
    <name>W4THC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68365">
        <property type="protein sequence ID" value="GAE68365"/>
        <property type="gene ID" value="JCM18909_1494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10068" checksum="E13D8D72460B41FC" modified="2014-03-19" version="1">MSIGQEFNDGTVVIQAKRRWTELFMLLIAWAIGFGGWVLTELNINHVLPDTWTTVGGVWLAVAVVAHIFVRIVIPYADPVILLSSSLSMGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK3</accession>
    <name>W4THK3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ORF">JCM18909_1545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68410">
        <property type="protein sequence ID" value="GAE68410"/>
        <property type="gene ID" value="JCM18909_1545"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023320143" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023320141" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="59"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="58"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="266" mass="27658" checksum="766BDA3C0724C08C" modified="2014-03-19" version="1">MGASTVHRALGRGDNADASAARAIMTTDTVPKMATVDAGGARFGGIAKGAGMLAPQLATMLVFLTTDAIIDPEEFQDSLAKACDITFSRVDSDACMSTNDTVVAMASGASGISLTGDELTDALTELCAILARQLVADAEGSNHDVKVTVAGAISTEAAVAVAREVTRSNLVKTAIAGNDPNWGRILAAIGCVPENIAPFDPDQVDVSINDIQICKAGGIGEDRNLVDMRPREVHIDIELHAGDAEAAVWTNDLTHQYVEENSAYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK6</accession>
    <name>W4THK6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67992">
        <property type="protein sequence ID" value="GAE67992"/>
        <property type="gene ID" value="JCM18909_1096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9988" checksum="A2DC1E52131DAD06" modified="2014-03-19" version="1">MSRAVYRIVQELLTNAAKHAPGQTTTLRVRGNPRDGISIDATNGYIGGWAGGPSAHSRGLKGITERVELLGGSLHYGLDDDLFHVHVDIPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK7</accession>
    <name>W4THK7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68415">
        <property type="protein sequence ID" value="GAE68415"/>
        <property type="gene ID" value="JCM18909_1550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="11905" checksum="83438DDC01CDD58F" modified="2014-03-19" version="1">MAKALGGGFPIGATMTFGSDVSGILAAGQHGTTFGGNPLACAAALAVICTIESDDLLTHVRQIGTLMSTALRQSHPCITEVRGTGALLGVQFDSDIAADLVVAARDAGSSSTLLTHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL4</accession>
    <name>W4THL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68425">
        <property type="protein sequence ID" value="GAE68425"/>
        <property type="gene ID" value="JCM18909_1562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6485" checksum="7C3953244853E27E" modified="2014-03-19" version="1">MAQLSRDTGIEYVTLGRYLRGQRDMSISVVYRCALHWAVSVESLVHEAGQKMGWTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM0</accession>
    <name>W4THM0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ORF">JCM18909_751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67674">
        <property type="protein sequence ID" value="GAE67674"/>
        <property type="gene ID" value="JCM18909_751"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="297" mass="30907" checksum="E507E9A90FF0BD5D" modified="2014-03-19" version="1">MAIILDQNSKIIVQGMTGSEGMKHTQRMLDSGTAVVGGVNPRKAGTAVDFNGGTTVPVYGSVKEAVEATGANVSVIFVPAKFTKSAVMEPSRPRCHWWSASPRVYQSRTPQSFFTAAQRSGKTRIIGPNCPGIISPGKSNAGIVPADITGPGRVGLVSKSGTLTYQLMYEVRDLGISTAIGIGGDPIIGTTHIDALQAFQDDPETDIIVMIGEIGGDAEERAAKYISEHITKPVVAYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKKEALEAVGVRVGKTPTETARLAHEAMESLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT9</accession>
    <name>W4THT9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68351">
        <property type="protein sequence ID" value="GAE68351"/>
        <property type="gene ID" value="JCM18909_1480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18736" checksum="34278349517DA231" modified="2014-03-19" version="1">MDHRAAVILLAIGAGLIVSRMGPLFKRQQKRIDDLNRVVREQITGIRVVRAFTRERHEAARFDATSSSLRDIQVSVGRTMAAMFPLVMLIMNLSQIAVFWFAATRIDDGQTEVGILASFTTYLMLILISVMMAVMLIVMWPRARYAQTASRKCCTPRRLSPLIPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI54</accession>
    <name>W4TI54_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68113">
        <property type="protein sequence ID" value="GAE68113"/>
        <property type="gene ID" value="JCM18909_1229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14449" checksum="312234C3F93D66BD" modified="2014-03-19" version="1">MRRRSAERHDAPVCSRRDGGLLAAFEDRLPFTPTVGQDKVSRVIDADLSADRPMHRLLQGEVGSGKKPSSRCERCCRLLTLGTRLSCWRRPKSLLSSITEPLSICWATWRPAGDWMPRRSPRVWRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI59</accession>
    <name>W4TI59_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68118">
        <property type="protein sequence ID" value="GAE68118"/>
        <property type="gene ID" value="JCM18909_1235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850760" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5378" checksum="E50E58984E9B017D" modified="2014-03-19" version="1">MLIRRGAMSIAAARVKPSSAPLTAAAADPLRIGSRERIPLVKVKDHRSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI91</accession>
    <name>W4TI91_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal recognition particle, subunit Ffh SRP54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68148">
        <property type="protein sequence ID" value="GAE68148"/>
        <property type="gene ID" value="JCM18909_1267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="3">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15071" checksum="583DF7522D5FE86F" modified="2014-03-19" version="1">MTGQDAVNTAVAFQEGVGFDGVVLTKLDGDARGGAALSIARVVGKPIMFASSGEGLKDFDVFHPDRMASRILDMATCSPSSSRPRKLSIRSNLRRLRPSSWPARGSSVSMTSSVSCVKCVAWANVQDHGHAPWRRPDEGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIA7</accession>
    <name>W4TIA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67884">
        <property type="protein sequence ID" value="GAE67884"/>
        <property type="gene ID" value="JCM18909_976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6045" checksum="6A8C77CE9106851E" modified="2014-03-19" version="1">MHTGRGMTTTGHCALRLMSQIPTPHNGVSLIVLAVIVVSSWLTPLDGRRTSWHGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID7</accession>
    <name>W4TID7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1425</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68297">
        <property type="protein sequence ID" value="GAE68297"/>
        <property type="gene ID" value="JCM18909_1425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="56"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="301" mass="32894" checksum="EECD9B39B67E0B4D" modified="2014-03-19" version="1">MTDVLTHADHVDKVSSRRAVPVDVEELTVGVPDRDETILGPIDLHLAAGSRVLVSGPSGAGKTTLLHAIGGLLEEESYDLTGRVNTWSGDVNVGLLQQEPIHSVVAATCGRDIAFGPENHRVPREDIWPIVEDSQRRARFTMPMDHSTTKMSGGQMQRLAIAGILATNPGLLLLDEPISMLDEESAAAIRDEIARMAHDRTMLVVDHHPDQWRGVLDQVVELTDHGTLKRSGILKTSWTRVRQRHCRHTPPSRARWLLLLAPSMPTVPSPTTCCCVVSPWLPGVVTSPFCRARVGLANPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII0</accession>
    <name>W4TII0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68586">
        <property type="protein sequence ID" value="GAE68586"/>
        <property type="gene ID" value="JCM18909_1733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="1">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="2">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27353" checksum="EF06A5A21F5A5AE3" modified="2014-03-19" version="1">MALTLQVKKNELATVPVQKLCCRRSEIAATLRFAGGIHLVQHRHLTIEAEVDTGGAARRLRQSIQEVFGFDTDLVVVNGAGLHSNTRYLIRMVRGGADLARLTGLLDRRGRPVRGLPVPIVGGGRCCQAAAWRGAFLARGSLTEPGRSMAMEITAPGEEAAMALVGAARRLDITAKQRESRHVDRVTIRDGDAISRCSPAWEHTNPCWRGKIVGCVGRCELLPTGWRISTTLTCVVLREPLLPLVLGWNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIM1</accession>
    <name>W4TIM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68278">
        <property type="protein sequence ID" value="GAE68278"/>
        <property type="gene ID" value="JCM18909_1402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7453" checksum="187BFAA8DB4862C8" modified="2014-03-19" version="1">MTNGQLIDVCGPISLRVPVKIDTTMTAEAVWIPSLRGDSTAPQSRTTVPDAPGTVVSLSAVETETSREAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN1</accession>
    <name>W4TIN1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68641">
        <property type="protein sequence ID" value="GAE68641"/>
        <property type="gene ID" value="JCM18909_1791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11794" checksum="74BEBA9E9B31D08F" modified="2014-03-19" version="1">MWYEFFKYTLFGPGVRALWHPRVVGEENIPTEGGVILACNHIAALDPIIVASMIDRKLTYPAKKELFLLATEASGRRSSRGSCAQSSRCRWIVRVAVLASMPWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS2</accession>
    <name>W4TIS2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1713 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68044">
        <property type="protein sequence ID" value="GAE68044"/>
        <property type="gene ID" value="JCM18909_1151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="COX24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1713" evidence="2">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6651" checksum="09FA37BA294213A8" modified="2014-03-19" version="1">MGQELRTYLGAPSFQFQRKRLTVGSVIKKRRKRMAKKKHRKLLKKTRIQRRRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ91</accession>
    <name>W4TJ91_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siderophore-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69015">
        <property type="protein sequence ID" value="GAE69015"/>
        <property type="gene ID" value="JCM18909_2195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039374">
        <property type="entry name" value="SIP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30157">
        <property type="entry name" value="PTHR30157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_9" evidence="2">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="SIP" evidence="1">
        <location>
            <begin position="141"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="295" mass="33249" checksum="8526FB71F994A30E" modified="2014-03-19" version="1">MAEYRPYLMRLLSRSLVEPNFIRLILTGDEVRFPQPCLDRRIKLLFIGEHPNPALTDPKVGDGWYQLWLDDPARPEMRTYTVRRVIENGIVIDVACHDGDGPGHRFATSAPLGSQVLVIGLDATAPGAEQTGINFRPGDAKRLLILGDDAAAPAVCSILKQLPTHAAEVEAVVEVPQLARRIEAGPDDHWTDSRGNRINIRWQERLGERGDRLAEAIEDHLHRFPLPRCQQDSPEEGPDDLLWNTPASPPQEFYSWIAGESTMVRRLRRILVNDHGVDRRHIAFMGYWRHGSAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC5</accession>
    <name>W4TJC5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68886">
        <property type="protein sequence ID" value="GAE68886"/>
        <property type="gene ID" value="JCM18909_2057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6147" checksum="7D850062023F6D0A" modified="2014-03-19" version="1">MTVIGASLLMGLAVWIAMPSATRKQEGRHLPAWSGIPVGFVVAWLLFLARAVWCGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC6</accession>
    <name>W4TJC6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68642">
        <property type="protein sequence ID" value="GAE68642"/>
        <property type="gene ID" value="JCM18909_1792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="346" mass="38491" checksum="5A8315E50229605F" modified="2014-03-19" version="1">MVPVGISGTTVRRKVLGIPLLDHPTLIFGKPMHFDVLADRTEEMAVLRWVTDEVMGAISDLTGQSYVDVYGFRVKHGNLKGKDVSKFVKPRPGGKPLPPPRVVKADAMKWLRRSHGEVTGHPLPAQPTIVAIHLHRPGDLAAAEHCLSGRVSKVYVMSGRRMKRTQAHAEALRHLCEGSVVLMAPEGIRSWASQVHRLDVEVARLALDAEALVVPAQVVAGQLNLGTSVDMSRHAGTPHSHAVLRAAADDVALALCKLTGLPYQDYPAVLADQRPHPIIWLFQMRKLRRDRRRHRRDAEERSREESVRDAEELARRRKNARLAAQLQARQASLADRLAERDIHPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK6</accession>
    <name>W4TJK6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">JCM18909_2329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69140">
        <property type="protein sequence ID" value="GAE69140"/>
        <property type="gene ID" value="JCM18909_2329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6893" checksum="8D6ADCA8101B8A7B" modified="2014-03-19" version="1">MAKTALKVKAARKPKFGVRAYSRCQRCGRPHSVYRKFGLCRICLREMAHAGQLPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM1</accession>
    <name>W4TJM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68737">
        <property type="protein sequence ID" value="GAE68737"/>
        <property type="gene ID" value="JCM18909_1892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6237" checksum="24BC2EB5FAFFCA02" modified="2014-03-19" version="1">MAIGTAGTAIGTRISLSEGPISDPIVAPGTTTPKRRTDVIAVWILPAFTVVLTTLAWFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR2</accession>
    <name>W4TJR2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68668">
        <property type="protein sequence ID" value="GAE68668"/>
        <property type="gene ID" value="JCM18909_1819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="4">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8394" checksum="34D252323BAC2BFA" modified="2014-03-19" version="1">MLQASHNPLVASHVKIIAAVLEGRTRLMPFEPKQEAIGFHRSIADAVAAHDAKAAAAAMRQIVTEAHQAMSSSMFAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW4</accession>
    <name>W4TJW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69086">
        <property type="protein sequence ID" value="GAE69086"/>
        <property type="gene ID" value="JCM18909_2270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="15771" checksum="2BAAD499922A33BD" modified="2014-03-19" version="1">MATIEFIEAREILDSRGNPAVEVEMILDDGTQARAAVPSGASTGQFEAVELRDGDKKRYSGKGVLKAVENVNEKIAEEVLGCDASEQRIIDQIMIELDGSDNKGKLVLTPSLVSPWLLLMLLLTVRSSRCTSTSADRTPTCCPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK39</accession>
    <name>W4TK39_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">bPH_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68798">
        <property type="protein sequence ID" value="GAE68798"/>
        <property type="gene ID" value="JCM18909_1961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10800" checksum="DF7A1DBCB687EF29" modified="2014-03-19" version="1">MHTRRHAKALFWPVVMGFVGVVGAAALLGIMPSDMRTQYWPIVVTIAVALIIVGTLSPWLTWFTTTMTITDRRVMLRHGVVVRRGHGVMIDSLIDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA3</accession>
    <name>W4TKA3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68863">
        <property type="protein sequence ID" value="GAE68863"/>
        <property type="gene ID" value="JCM18909_2031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="451" mass="49742" checksum="FE6A245E2FCCC261" modified="2014-03-19" version="1">MCPAPTPVVCFFVGVESLVVRGVGMWSGLRSRRWRVRAVACLVMVAALVCAGVAPRPAAADDPDQPASDGKTGVWPDHGDSLPNESGIKGTWRDGWCRRGEGYSVVVDLSDIPESWRGDLTPTPEHVKQYGPTVRDGWIVRCHQGPWTMDYDKPHEWPALEIDVESVGISTDLRSDYVQPEGTTKPLGIFEASLEILGVRNVANAKWKPHTNSGQNAYVFDNAIWIRPDARTGSLTGGWPPNQSLTDEPWPSKSNNRLVNTTVRLEGPISAGMVAYIGYDVAADCRFNVGDRDWSNRVCLGDAARHPRTYVGHPEWTLTPQYAQERPHPGPAPKPGPTSSGRAPHSGTQPRPHRRPHSGPQPHLGPGGHGGRRDVAGVHAGASVRRGGVPHARLSLLCRCHRLRRHRQRRPPRYRRLGRLPRRRRCRHLARHRRCLVVVECGALSGRACGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB4</accession>
    <name>W4TKB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68952">
        <property type="protein sequence ID" value="GAE68952"/>
        <property type="gene ID" value="JCM18909_2129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="174" mass="19362" checksum="F699397368F09F6E" modified="2014-03-19" version="1">MEVKLACGADMNRVWEGATQPPTEHEAECLACQAVRTEALRADQLRDDTVAEDAQTKVVVDPLKLSSVWRSYAADLSPRHCVFDDDGGQVEVRETVLAAIVRNSLADCEDGRLNRIRFSVPHTPLRLRIDLSVARGVRIPDCAKRVRHRISTAMTRELGGRPEAIDIIVEDIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC2</accession>
    <name>W4TKC2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68599">
        <property type="protein sequence ID" value="GAE68599"/>
        <property type="gene ID" value="JCM18909_1746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7138" checksum="55B29151E1BB66A3" modified="2014-03-19" version="1">MVLMTVGRNNGSNFVVTDESFKSTGFGGCVHEDGGPGSGMDEVGIIVHGAYRDFDEVNVIVNPDEGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH8</accession>
    <name>W4TKH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Magnesium and cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69445">
        <property type="protein sequence ID" value="GAE69445"/>
        <property type="gene ID" value="JCM18909_2660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="62"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18420" checksum="3CA225BD7A151FFB" modified="2014-03-19" version="1">MLILIGNALTPGKGYAEGPFTSEAELREMVDYAEASDLIEAGEREMIHSVFELGDTLTKEVMVPRTDVVYIPRTKNLRQAMSLALRSGFSRVPVVGEGFDDIRGIVYLKDLSQRYSTILTVTPPKASNRLCGLPRSAQTLSPSTRCCAKCSETVTISSSSWTSLAARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI7</accession>
    <name>W4TKI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68674">
        <property type="protein sequence ID" value="GAE68674"/>
        <property type="gene ID" value="JCM18909_1825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021401">
        <property type="entry name" value="DUF3040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11239">
        <property type="entry name" value="DUF3040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15570" checksum="61DCD956D2D74DF3" modified="2014-03-19" version="1">MPLSAEEQRRLAELEEALSTDDPDFARSFSRRASATCPHPSHNALEQRRMQHRRARRRQILIGSVMVLLGLAGVVGGVVLASGVLAVVGFAVMALAVGVLLSTGGGVMPRSSGVRPRGGQREPHCESFTARMEERWRRRQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM8</accession>
    <name>W4TKM8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68714">
        <property type="protein sequence ID" value="GAE68714"/>
        <property type="gene ID" value="JCM18909_1867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11522" checksum="1FC86FAEADC77F80" modified="2014-03-19" version="1">MAFARGLGSIAEWDPADRFADVFMVGAGTCGCSLSHVAEIWLCVRLICLRGREERPIWAVPARPTLTIAVEVIVWVVLEIIGVTLVDSSRRSALDVIDLCSGLAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR5</accession>
    <name>W4TKR5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69122">
        <property type="protein sequence ID" value="GAE69122"/>
        <property type="gene ID" value="JCM18909_2310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11754" checksum="340ADB1E310B5717" modified="2014-03-19" version="1">MWFWALVTCYWALVWRTPVWDIDDLYFATRSGTPGGRIDWADFARLTVYDLVERNGRFSDMMVQLTMAMGGWIRVPLIFSSVSASLALWLMVRASFEIYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT3</accession>
    <name>W4TKT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Respiratory nitrate reductase beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69033">
        <property type="protein sequence ID" value="GAE69033"/>
        <property type="gene ID" value="JCM18909_2214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Nitr_red_bet_C" evidence="2">
        <location>
            <begin position="188"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="337" mass="36530" checksum="FE85CD0AA9305A6A" modified="2014-03-19" version="1">MRIHSCSICRASANTASTRHVFLPAHPGRSTSVPRMESSLSTRTIVAAGACVCPAARTRRCSSTITAVKPKKCTLCYPRLEVGQPTVCSETCVGRLRYLGVLLYDADQVTWAASQPDPRTLYAAQREILLNPNDPEIITQAKANGVPHSWIKAAQASPVWQLISHYQIALPLHPEYRTLPMVWYVPPLSPVVDAVSASGNDGEDHRVLLAAISQMRISLEYLAGLFTAGATAPVELSLRRLAAMRSYMRDIFLGNEADETIPEAVDMTGKDIQSMYRLLSIAKYDDRYVIPTTCGGLPDGIADLGRCPVSGSLEAFHSISSPVSAPEGTPTLPLEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU0</accession>
    <name>W4TKU0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69565">
        <property type="protein sequence ID" value="GAE69565"/>
        <property type="gene ID" value="JCM18909_2798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8160" checksum="96869E8019507583" modified="2014-03-19" version="1">MSLSYVDSGIILRTPAGMGSVMHSQAVTLLRFVPAALVLFALAIAGVINQAPILTIVSGLMTVALTITLSMVHFFDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU6</accession>
    <name>W4TKU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5-deoxy-glucuronate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69570">
        <property type="protein sequence ID" value="GAE69570"/>
        <property type="gene ID" value="JCM18909_2803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="218" mass="23513" checksum="9B88CE814CA78ED4" modified="2014-03-19" version="1">MTELVLRSGSTASGCRDVVVDPKCAGWTYSGLTIASLTKDETLELTTDDHEYLVLPLEGSFIVQGDGFRADLAGRSTIWGEVTDYAFVPRHRTITVTAVSGGRVALPNALASEDLEPRYCPSKEVRVELRGAGNCSRQVVNYAVANPVHTSRLLACEVLTPGGATGPPTLLTSTTRSRRSSTNSRRSTISRFAVTSTAQGWHSTGPMARRTVPSTWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL18</accession>
    <name>W4TL18_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="7" type="ORF">JCM18909_2327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TL18"/>
    <dbReference type="EnsemblBacteria" id="GAE69138">
        <property type="protein sequence ID" value="GAE69138"/>
        <property type="gene ID" value="JCM18909_2327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13485" checksum="D6F405BA3D92B588" modified="2014-03-19" version="1">MKSLKIKKGDRVKVIAGNDKGAIGEVLSVDPARERVVVEGVNIRKHHRRDMPTPQGGTTKGGIISSEAPIHVSNVQLVTKIDGKDVVTRVGYRRVDVTKRRPDGSEYAAQRSVRYLKKEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL28</accession>
    <name>W4TL28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68869">
        <property type="protein sequence ID" value="GAE68869"/>
        <property type="gene ID" value="JCM18909_2039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18355" checksum="97A602FBB394A979" modified="2014-03-19" version="1">MGDKPVVVGETGIVGTRLGFPTVQDDPAKVPSAWIFVGPDDVTMTNLGTAAGTFVPYGTLKPTVLGDGWSLEKPVGQTIGARIVGSMIDGTYSIEYQDDAGHWVNVTKAPKPEKDKLISGQLPVSSVWDSADVAQVWVDNPSQPVDIGYELPRGLKHHRYKMRMITYGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL45</accession>
    <name>W4TL45_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">JCM18909_2353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69163">
        <property type="protein sequence ID" value="GAE69163"/>
        <property type="gene ID" value="JCM18909_2353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="17"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="279" mass="29935" checksum="7F4A6BE0BD5BEDAF" modified="2014-03-19" version="1">MLGRNRFQIKTPDQIRTMRRVGLVVAEGLEAMRAVAVPGATTADIDRAGRDVLEQHGARSNFLNYGGDWGLPPYPGVACVSPNETIVHGIPGERELKDGDIVSIDYGAIVDGWHGDAARTVLVGDVSEEARTLSEVTRESMWAGIAKVAPGARVGDISAAVQASLESHDRDYGIIREYTGHGIGTEMHMDPDVPNWGRAGRGPKIVEGMVLCIEPMATLGTEDVATLDDEWTVVTVDGSWASHWENTVAVTSKGLWVLSEPDGGQAELEKRGVPFGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL87</accession>
    <name>W4TL87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69506">
        <property type="protein sequence ID" value="GAE69506"/>
        <property type="gene ID" value="JCM18909_2728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8885" checksum="DCB36D58D0BD118F" modified="2014-03-19" version="1">MGENNSGKSTIIKLLADVYEAFAGSVRIAGIGLRTLDRGSYYSLLHNGISVLRLFFDCRNPWWRTWHWTPKPGRSCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR4</accession>
    <name>W4TLR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69368">
        <property type="protein sequence ID" value="GAE69368"/>
        <property type="gene ID" value="JCM18909_2577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8836" checksum="1DBF4CCD82867D9A" modified="2014-03-19" version="1">MNKRPARPTRSRRRVSVAPATRQLRNARQMMADDIAVARAVERGELETEEHPAHGATNAEKAAESGLQPQPSDHEKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS9</accession>
    <name>W4TLS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DeoR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69915">
        <property type="protein sequence ID" value="GAE69915"/>
        <property type="gene ID" value="JCM18909_3182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13594" checksum="B591C86C7F21A9FD" modified="2014-03-19" version="1">MAAQRSERLVNLVIALLVTDRPLTRAQLRDMIEDYRKVSEVAFQRSFERDKEELRRIGITVESVTLDTFFGDEVGYRIPRADVELPPVQFTQAEADALATAARVWRESVLDESSRLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT8</accession>
    <name>W4TLT8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ORF">JCM18909_3193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69925">
        <property type="protein sequence ID" value="GAE69925"/>
        <property type="gene ID" value="JCM18909_3193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="110"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE69925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33427" checksum="62714A910B482C78" modified="2014-03-19" version="1">MTSSVGGQAEDYLRHLVVERGLSDNTVQAYRRDLLRYQEYLGSRGIGSLAEVTRVDVEEFRRHLDHIGLAPASVTRCVVAVRNLHRFAVGSGQVQADVTAGMSPGTRSRRLPKALSMDQVESLLAAPDTSTPEGLRDAALLELLYGTGARVSEICALDVDDIRPVLDDPDLGLRLIGKGDKERIVPLGSYAAKAVDAWLIRGRPAWAEISNGEHALLLNTRGRRLSRQSAWAVIRRAGEAAGLDVEHLSPHSLRHSYATHLLDGGADVRVVQELLGHSSVTTTQIYTLVTADHLREVYRSSHPRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW3</accession>
    <name>W4TLW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69507">
        <property type="protein sequence ID" value="GAE69507"/>
        <property type="gene ID" value="JCM18909_2732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="7825" checksum="A0B8324C966DBEC2" modified="2014-03-19" version="1">MSATLADVAITKAARVGAIRSLKPLIIDAPSGCAVVKKAQAEASIQQAHPELLEAARQGITHAEPQTTSYLNHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX3</accession>
    <name>W4TLX3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homolog of fucose/glucose/galactose permeases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69194">
        <property type="protein sequence ID" value="GAE69194"/>
        <property type="gene ID" value="JCM18909_2386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7991" checksum="3FCBD61511D4F833" modified="2014-03-19" version="1">MQLRDGYLNRTPFFQFILLSICFPMWGMAASMNDILITQFKAVFALSDLASAFVQSAFTADTSLSPYLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM08</accession>
    <name>W4TM08_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69428">
        <property type="protein sequence ID" value="GAE69428"/>
        <property type="gene ID" value="JCM18909_2640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="14"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="464" mass="50236" checksum="AA39D6792D781457" modified="2014-03-19" version="1">MSLAAATGEDGPVLQVKDVEVRVGARLLLNPVSFQVATGDKIGLVGRNGAGKTTLTRVLAGEALPAAGSVRRTGELGYLPQDPRDPDMETIARARILSARGLDHLLERMRTLECQMANGSEEDRAVAMDKYAKVEDRLVAAGGYGASAEAARIASNLGLDDRVLSQPLKNLSGGQRRRVELARVLFSGADTLLLDEPTNHLDADSIVWLRSFLQSYSGGVLMISHDTELVEATVNKVFHLDANRATLDIYSMGWKLYLEQRAADEKRRHKERINAERKAAALRAQADKLHAKATKAVAAQQMARRAEKLLAGVEVERAVDKVAAIRFPDPAPCGKTPLTARNLTKTYGSLEVFTGVDLNIDRGSQVVVLGLNGAGKTTLLRILAGKESPDTGEVIAGHGSSLDTLPRSTICSTWTALCWRTWPVPRSTSMRPRCAKYSGPSCSPATMCINRPGCFRAARRHVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM11</accession>
    <name>W4TM11_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport system permease protein OppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70015">
        <property type="protein sequence ID" value="GAE70015"/>
        <property type="gene ID" value="JCM18909_3295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="278" mass="30098" checksum="8DF229036A8269F6" modified="2014-03-19" version="1">MFRYIVRRILQMIPVLIGTTFIIFCLVFALPGDPTAGRCGERPCPPAYVAAFRAEYNLDKPLLVQYGLYLEKLLHGNLGVDYYGNTVVSELGARYPVTIKLAVIALLVEIVIGILAGVWAGVRRGKFIDYFVLVSSLIVISIPIFVIGSLAQLVFGLRLSWFPVTAGDGSWGALVLPGLVLGALSVAYVARLTRSNLLENQRADYVRTAKAKGMSPSRIVTVHTLRNSLIPVITFIGYDFGALWVVPSSPSASSTSTGSAITSTGRSTNATVSRWSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM32</accession>
    <name>W4TM32_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69796">
        <property type="protein sequence ID" value="GAE69796"/>
        <property type="gene ID" value="JCM18909_3051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="22012" checksum="E9D0BFDFFE0CE247" modified="2014-03-19" version="1">MGDELLKKMIEMTKLCRRMVMDRYHGHMLKAARHDAIVELLRDRPAMRTVDVARNLSVSMATARRDCIALEDKGIIERSWGGIQLVTSVDDHFGDVMNHHTQAKAAIARKATELIHDGDTIIMDIGTTVHHLSGLLTGRSITVLTASLPVFETLRTAPDVTVVVLGGVWSERYQCFDGQFVADALTHHQADLAFLAAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM55</accession>
    <name>W4TM55_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69483">
        <property type="protein sequence ID" value="GAE69483"/>
        <property type="gene ID" value="JCM18909_2702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021447">
        <property type="entry name" value="DUF3097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11296">
        <property type="entry name" value="DUF3097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="8046" checksum="CEF64CBF856499B1" modified="2014-03-19" version="1">MDEDFKLGTLKRLGLPHSTQADVGKAWQAMLARVRDWHDLDPRFNTEMEKLIDFVTCDHVDELDNEEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM74</accession>
    <name>W4TM74_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69632">
        <property type="protein sequence ID" value="GAE69632"/>
        <property type="gene ID" value="JCM18909_2872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="416" mass="45706" checksum="8F52789D6EE6A508" modified="2014-03-19" version="1">MPATATYATLELSHRCCDLALARTPFRRARQPILAVVFFLIVLALWQSMPTMLAAITSSPEPFTVWPLVFHDINLYYGAPATTGCFLALIVVSLLPVMVLPTSPLDIRHRFVMLPVVGLNASFFNTAPQFRALFRSRYTLQAALLSAGFVALLATRVAGPSSVWGVEPLTIGGFFQYATLAPSFRIFEPRLPASRFYLRMLAAQYVLVAPMLVVAVLTDIFTNHPAHSTILATAGVCGSALITIGVGIFCPCSRRQSPVDPAGVRDCADHRNGARRILRNPPSSCRSIYRPWYRLRSLTHHLQHRHHFRSTEGSPMKDPKVYLTSLIIAIIATLTLATGIILILMFSVHDESAYRTGLFGSVYFRAAPNPQGNIDATMGVASLPRLGIVAAAIFAFTLLVSAIYFRLKAYRASLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM91</accession>
    <name>W4TM91_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RfbX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69523">
        <property type="protein sequence ID" value="GAE69523"/>
        <property type="gene ID" value="JCM18909_2748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="15985" checksum="D7B2F840000FD8A3" modified="2014-03-19" version="1">MRSFLIGIVPFGLLYLLIPPVLPWLLGAKFHQSADIAVALVPWLFVNFVTSPISNMFIVTRNNGIALVFAIVYAAVPLTYLNLSHLSIVGTIYQMSFIMAGLLVFYIGLALVVAKRFDQKNVKLDGEVEAAQEAEVTSEDESNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH7</accession>
    <name>W4TMH7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mg-protoporphyrin IX chelatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70190">
        <property type="protein sequence ID" value="GAE70190"/>
        <property type="gene ID" value="JCM18909_3488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mg_chelatase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="6">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="244" mass="27124" checksum="4A63B6C1A3493633" modified="2014-03-19" version="1">MPEPRTVQVPVVELPVGATEDRVTGTLDMETALREGRRRFEPGLLAAAHRAILYVDEVNLLDDHVVDLLLDSAAMGVNTVEREGVSVTHPARFTLVGTMNPEEGELRPQLLDRFGLCVTVSGEDDPDKRTEVIRRRMAFEDDPGGFSRTWEQDGHKLSERIQRATELVTQVVISDETLMTAARTCINAHVDGHRADIMMVRAARTLAAWNGSTEITTEDLSQAARLVLPHRMRRQPLESVGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ6</accession>
    <name>W4TMJ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69767">
        <property type="protein sequence ID" value="GAE69767"/>
        <property type="gene ID" value="JCM18909_3018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7384" checksum="F74F469CC3597424" modified="2014-03-19" version="1">MMTWNKLNEQWADGSNPMLDPSAPGYDVDASDGALPGLARVVSVIAARPIRAGHLLRDLGVTAIAELKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM2</accession>
    <name>W4TMM2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplJ</name>
        <name evidence="10" type="ORF">JCM18909_2918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69673">
        <property type="protein sequence ID" value="GAE69673"/>
        <property type="gene ID" value="JCM18909_2918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="204" mass="21001" checksum="6588548AE1A01C6A" modified="2014-03-19" version="1">MARPDKVAAVAELKEKFSSADATVLTEYRGLSVSALKDLRRSLGSDATYAVAKNTLTRIAAREAGIEGLDDQLVGPTALAFINGDVASVAKGLKNFAKDNPLLVIKGGVMDGNVLDADQVKKLADLESREVLLAKLAGGLKANLTKAAVVFNALPSKAARGLGALQEKAAADPSVIGGAGEASDQEPKTTETPEASAAQDNTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU8</accession>
    <name>W4TMU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70041">
        <property type="protein sequence ID" value="GAE70041"/>
        <property type="gene ID" value="JCM18909_3323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5839" checksum="47EA1ADD48217842" modified="2014-03-19" version="1">MMRSFMENLGLNRFQAVLDQVSHNHVSVMTVAVYGGLTVGACVIAYLNEIPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY7</accession>
    <name>W4TMY7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70086">
        <property type="protein sequence ID" value="GAE70086"/>
        <property type="gene ID" value="JCM18909_3376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20153" checksum="F18BA220EDECB186" modified="2014-03-19" version="1">MHQPHYEVDPRESSFLLYVVSAGQSRCEHLIRCRLMDKRGHTMIKNRLVAAGAAAALATGTALMAVPAHAATPAPAPSPAPSAPAKPGINVSKLPIHIDFDCLKHNAQERHQIELKIAKILVQDGTAKSKAVAVDSAKEIIATILKDPSLLANPGALVAKIVKIIADNASRPSATPPLSAISSSSLRTSSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ6</accession>
    <name>W4TMZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific DNA-binding protein Dps</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Dps family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70096">
        <property type="protein sequence ID" value="GAE70096"/>
        <property type="gene ID" value="JCM18909_3386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin" evidence="3">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10799" checksum="FCE2F6BB113F88DC" modified="2014-03-19" version="1">MSADEIAERMRALHASPDGRPAVVAASTTLPESPQGEVLTHDAIKVVTASIESVTGTMREVHDQVDEEDPTSADILHGLIQQLEQQAWFISAETRTPTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN60</accession>
    <name>W4TN60_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome-c oxidase</fullName>
            <ecNumber evidence="5">7.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome aa3 subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JCM18909_3462</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of cytochrome c oxidase, its function is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase bacterial subunit CtaF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70166">
        <property type="protein sequence ID" value="GAE70166"/>
        <property type="gene ID" value="JCM18909_3462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021050">
        <property type="entry name" value="Cyt_c_oxidase_su4_actinobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12270">
        <property type="entry name" value="Cyt_c_ox_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE70166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7080" checksum="FAB9B99D5B489447" modified="2014-03-19" version="1">MIDGAGPVGFFPPQSIWPFWCALVVAIMCLGPIFGWWISLLGLGIGIWAASGWAFEYYRGDYAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN74</accession>
    <name>W4TN74_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome recycling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69863">
        <property type="protein sequence ID" value="GAE69863"/>
        <property type="gene ID" value="JCM18909_3125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="3">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15889" checksum="95890E1EF204235C" modified="2014-03-19" version="1">MGSAVDHAREEFAAIRTGRANPAMFNKLMVEYYGTPTPLQQLASFQVPEARTVLIAPFDKSCVNDVEKAIRDSDLGVNPSNDGNVVRCVLPALTEERRKEYIKMAKTKAEEGRIAVRNVRRASNDVVKKSRRRTRISLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND0</accession>
    <name>W4TND0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bis(5'-nucleosyl)-tetraphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69903">
        <property type="protein sequence ID" value="GAE69903"/>
        <property type="gene ID" value="JCM18909_3169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="4463" checksum="4287A68D6A40CA4E" modified="2014-03-19" version="1">MHIIPRYDREPGINAIRSAMPRRPIEEVAAMVTGESNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF9</accession>
    <name>W4TNF9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3185</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69918">
        <property type="protein sequence ID" value="GAE69918"/>
        <property type="gene ID" value="JCM18909_3185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="19551" checksum="CB38226C358A7AC0" modified="2014-03-19" version="1">MPKASGETVKPAAGLPTVKEVQGAPAVTIGKATKPNKLVVQPLIKGKGAAVTAHDSIDVKYRTYAWSSGELIEDGYSGEPVTGSMNSVIPGWKKGLIGQTVGSRVMLIVPPADAYPNGSTNPPVKKGETLIYVIDILSAQKRILSGDGFARDMPAYTCLRVDGSRAAPPHRELHHSTTPLLRQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH0</accession>
    <name>W4TNH0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69759">
        <property type="protein sequence ID" value="GAE69759"/>
        <property type="gene ID" value="JCM18909_3010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="SSF50952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22340" checksum="B66414D8A8CC7D4E" modified="2014-03-19" version="1">MAADLHHDWYWITDGSSSTVRSLLAVDKMGKEVHRVAWEPAFHDVEAMSWARGVLYVADIGDKKAQRRGIRVMSPTSTAAKQSTYYEWMFTYPDGAHDAKVLTVSPKGSFYIITDGPHPAIYRGGPQVSRTESNPLEKVADAPAGVKDATFLPDGSRMALLTDHEVRIVDAYSWKTVANAAFSGGQAITTDTTQKNFGDCDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ4</accession>
    <name>W4TNJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inositol-1-monophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70112">
        <property type="protein sequence ID" value="GAE70112"/>
        <property type="gene ID" value="JCM18909_3403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="270" mass="29791" checksum="484E7E9AD34D51D7" modified="2014-03-19" version="1">MKRLLFNAATAIRRAAHSNRAQRGAPSGHDSPGGDAQFDIDLIAEQALWRYLERARTPLAVYTEDGALRSVGDGDPEAFLIVDPIDGTRGAAAGLESSMISLAVTRTSDTPRLRDITDALLMELTTGRWMYAHGDSFEAHGYPYTVPAQTNVTELKRMFWSIEFNGHPVHLMNDAYGHLVDMSSNTGGVFIFNSCAYSISRIITGQLDAYVDVGNRILRDHPETRIDFERAGRGNVCICSPMMLLLPYRSLRRQASSLPTHTATVSTICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL9</accession>
    <name>W4TNL9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70331">
        <property type="protein sequence ID" value="GAE70331"/>
        <property type="gene ID" value="JCM18909_3645"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="277" mass="30377" checksum="0B11D03CB82B1C8A" modified="2014-03-19" version="1">MIDLSGRQKKSHAASTEIPFGPDKLFRATDLPDLIFHVEVCEDLWMPVAPSSRAALAGAIVEVNLSGSPITVGKSRQRHELCKVTSSRNLQAYVYAAAGPGESSTDLSWDGQTMIYENGSLLAATDRFSPEPGYCLADIDLDLLRQERLRQGSFDDNALAQPTQAPWRTTTFTLDPPHDDIGLERPVNRFPFVPNDPDQLAQNCYEAYNIQVYGLRRRLESMGSPKIVIGVSGGLDSTHALLVAAKAMDQMGRPRTDILAFTMPGFATTDHTKKTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP8</accession>
    <name>W4TNP8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69834">
        <property type="protein sequence ID" value="GAE69834"/>
        <property type="gene ID" value="JCM18909_3090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6387" checksum="894346C9840E7AE9" modified="2014-03-19" version="1">MLRDLESDGKAYVFYPRVMPVTNKERNVTKLRQAYALGMAQVNAELPQWRDFLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP9</accession>
    <name>W4TNP9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA_permease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70356">
        <property type="protein sequence ID" value="GAE70356"/>
        <property type="gene ID" value="JCM18909_3671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22007" checksum="10930508813B51BF" modified="2014-03-19" version="1">MVIAVPWDAPELGASPFVAVLNRAGIPAASEVMTLVIVLALLSSLNANLYGAARMLGSLAERGMAPRVAMRTRGRSVPTVAVLASVAFGFCCVLATFEWGDAVLGTLLNIVGSTIIVTYFFTICSQYVLRRRAEKEGTPLPMRLKGFPMVNWAAMILLIGIVVLGMFSPDVRAQLMSTGALVVILYVIGVGWSHHAGRSPFRPTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR2</accession>
    <name>W4TNR2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquinol cytochrome c oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70177">
        <property type="protein sequence ID" value="GAE70177"/>
        <property type="gene ID" value="JCM18909_3474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="18413" checksum="E28596D246EDE06C" modified="2014-03-19" version="1">MPMARPEAQAPSKKTKFTDEEIASVGAYVASLAPGPKVPSSQSLNTSNLKAEELARGAELFKTNCSACHNIEGRGGALPEGAYAPSLMKTSNKHIYEAMRTGPQQMPVFSKSVITDQDAREIIGYLQTTHSEPNNGGFALGGIGPVTEGLFGWIIGIGGLVLVAGWLARKGARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW6</accession>
    <name>W4TNW6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70232">
        <property type="protein sequence ID" value="GAE70232"/>
        <property type="gene ID" value="JCM18909_3530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21254" checksum="0B5FA021B300A6BC" modified="2014-03-19" version="1">MSEPTVVAVVTIVLIVLPLLWALSGWFSRRSSRAMLRGVGLALIPVGLVLTGLMRLLVRAIRLTVDWFAGTVMTTTIWIGIIVIAVGLVTWFVSGIVSPVDRETGRQRRQDHAARKQARGDSQTKGPRSTKTPDHNPTGNNAPTTGTAPSQGASKAQQTPTDAPVATSGPASSPKPTISTADKDEDAELEEILRKRGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP27</accession>
    <name>W4TP27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein hemolysin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70292">
        <property type="protein sequence ID" value="GAE70292"/>
        <property type="gene ID" value="JCM18909_3600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7417" checksum="8E67502EFB56E9AF" modified="2014-03-19" version="1">MVAPSILAYMRAAVVILILIGGVFYTIGALSYARQKPNPSPTWFGFHEVFHSCTAVAAICHAVAIGLAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP32</accession>
    <name>W4TP32_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lacto-N-biose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70471">
        <property type="protein sequence ID" value="GAE70471"/>
        <property type="gene ID" value="JCM18909_3798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035363">
        <property type="entry name" value="LBP_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17385">
        <property type="entry name" value="LBP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LBP_M" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6743" checksum="53F909BBB0D4CF5E" modified="2014-03-19" version="1">MLINVGAAGTAFSGESEWADERVTSAVRRFVAAGGGLVDVGDPTAHPARGAVYQLSDVLGVDRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK9</accession>
    <name>W4TPK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA double-strand break repair Rad50 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70348">
        <property type="protein sequence ID" value="GAE70348"/>
        <property type="gene ID" value="JCM18909_3662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18749" checksum="B99D313B56C58F25" modified="2014-03-19" version="1">MAAELTELGRNVAEEREEAQTAVDEAQKKITQAEEAETQARQTLTAARVSEESTKARQQLDRIHELKTRITAEQQRLDTEKVTSEALSALRKAVKADDLARDKALMASPQLAIEHLADGVSLRIDGADLDVPIGATNQRRVDDELVMEMGEAWRVRISPTSEVMTLGNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPY1</accession>
    <name>W4TPY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70592">
        <property type="protein sequence ID" value="GAE70592"/>
        <property type="gene ID" value="JCM18909_3942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5303" checksum="97BBCCB13A313C19" modified="2014-03-19" version="1">MWPSNVIARGSRRSSHGDVIIGPCLALSAMAAPDANTVLTWRWPPATLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPY9</accession>
    <name>W4TPY9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70443">
        <property type="protein sequence ID" value="GAE70443"/>
        <property type="gene ID" value="JCM18909_3768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11903" checksum="2DD66AF1DBD7FD1E" modified="2014-03-19" version="1">MHHSSAEIGLDSSVLVPKVASFEDEGGDRFVELVDVEGSVHAGGELSGYSVVDVGDRASDTEGKGMQMNFSTWLYVRLGTLENQTMDLHQRFSRFSTTSNPTYVSSQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ98</accession>
    <name>W4TQ98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor, type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70568">
        <property type="protein sequence ID" value="GAE70568"/>
        <property type="gene ID" value="JCM18909_3915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="70"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="20953" checksum="0882079C9F584DD0" modified="2014-03-19" version="1">MSWHPHPIAVALAVIMLIVAVWFGVQGRHTRGRTATTILDVLLAVLVGLISLHPVVGESGRQSSSVDADIVIMVDTTTSMAARDNGGKTRLSGAIHDIAALASVFSGARFTLVTFDNDARVLVASTTDTGTIISAANSLTWREDTKAPAPISVWPCPPPSGFCRRLANPRPKPPGWCSTSATGSRRLPGRPALSPLSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDY8</accession>
    <name>W4TDY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system, response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67175">
        <property type="protein sequence ID" value="GAE67175"/>
        <property type="gene ID" value="JCM18909_217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7059" checksum="2F1C4F4DF53CF51B" modified="2014-03-19" version="1">MTVRVLIADDHPVVRAGVTALLDTDPDIEIVATAATPSQALAAAATVDLDLVLLDLQFSSDADAPSGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE52</accession>
    <name>W4TE52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fructosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_91</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67056">
        <property type="protein sequence ID" value="GAE67056"/>
        <property type="gene ID" value="JCM18909_91"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37002" checksum="C37932A70EE9BDBE" modified="2014-03-19" version="1">MISGRHETPDGRGGFGCILRVYRGIHDLPQDRPPQKNAIDYEVAGLMWLAAARPDGAGIVEVLDHGKGWLTELELSTVHPTREAAEDFGRRLAHTHAAGASHLGAAPDGFVPDDGYIGRAPLPLPSEPISSWGEFYAQYRIEPYMDSLDADARAIMSRLVDRLASGALDHDEPALVTCPAARTHGDMWLATSCGPPTVSSSLTLPLRVVTPKKISRPCRYSVPHLPSESGPPTTRNRHWLTAGRTESGSTNSICSSCIAGSSAADTSTRPSRSPGNGCDPVSRSRTSPRGPIANGPGHHQSSMRSAHDHTCSTCRAKTPLPPNQLACPTPLTPEQFSRPDNRGPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF86</accession>
    <name>W4TF86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67093">
        <property type="protein sequence ID" value="GAE67093"/>
        <property type="gene ID" value="JCM18909_129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="5326" checksum="F2504060F725863D" modified="2014-03-19" version="1">MAAVEQGKPFGLMSRTEPDKVLDTVDAKELFWQDCSGCLGVRRSRLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFD8</accession>
    <name>W4TFD8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67242">
        <property type="protein sequence ID" value="GAE67242"/>
        <property type="gene ID" value="JCM18909_287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19634" checksum="1EFADF626303D25D" modified="2014-03-19" version="1">MEVYLTWQFWYQVLSAFAFGVASSLVPVLNSELFVVGALGSRLLGPLEVALGLALGHGVGKQVMFVGIRKGSNSRWIKHKEPKPVAVGSWRWRLRRWNDQAAHIVETPRRGMPLLFFSAITGVPPVYLVVIYAATTKMNFFGGFFVGDAWILYTMLLASLSNPVWIPLHYLNIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFI2</accession>
    <name>W4TFI2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67193">
        <property type="protein sequence ID" value="GAE67193"/>
        <property type="gene ID" value="JCM18909_236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="439" mass="47534" checksum="3759EAD296AD555D" modified="2014-03-19" version="1">MSVHQELPPCNDLNEEAPMKDTITAIMKRPSIAHLLRAHTRFNRRLGNHFAASITYFTVLAIIPVIAFAFAVLGLVLSRLSPYLLNQVVDSVVGLATESSDKQQIRAIIENAMKVGGSVWAFVVSILTALWAGIRWVGNIRKGIQAEWAPDFDMVGDDRGFMRAKLSDMLTFLGLLLVTLLTIITSQVGSSMTGMLARWTGLDSVPGYGLLLTLAGLVATTIAGWLLFIFLYIVMPRVKTSWPPILRGSLAAGFALALVQVGAGYLVRAFNSNKAVQAFGSIIIVMLVFDLVARLILFIASWIATANQPAIDKEWNDCDEPLLGREDCMTAEGHWEAALADRTAKQATKDDEDGKEVVPPGYTVVDGVTQKTAMGGGERDQRPHKTEDAVSLDNAPASSGTVASSYTKPRRWPIIGASIVGAIGGMAVSAILGRRREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFR7</accession>
    <name>W4TFR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent proteases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67621">
        <property type="protein sequence ID" value="GAE67621"/>
        <property type="gene ID" value="JCM18909_694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="218" mass="23002" checksum="64320712787DAF30" modified="2014-03-19" version="1">MNTIVLGIDTSTAVSVGLARGSEVLVSLHYDDPRAHAEQLMPLIHRGCEEAGIALTDIAEVAIGVGPGPYTGLRVGVATGRVLAHLAGLTPHPVCSLDILARQWAGVDGEFVVCTDARRHELYWARYDASGHRLDGPNVTRPEDLPKGLPVGGPGCLVRGLTPTPGSPEFLDAGVLAASWQAMPDVGLEPLYLRDPDATVPTTRKATLTPTRLTLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV3</accession>
    <name>W4TFV3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_39</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67009">
        <property type="protein sequence ID" value="GAE67009"/>
        <property type="gene ID" value="JCM18909_39"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16195" checksum="9FBBE272B15744E3" modified="2014-03-19" version="1">MTASRQRFWVTSWWLEASSMTLLIAYERLATAHLANTASLLLPVSNLPAVLVLIPFVFPAGWVAVLTMPIGVNIGPNLSCAGLLATLLWRRIIEAHDRPARQVYSPRHTHGPRKHPRLGMHDMGNELCRTGTAVNLRCRQDAPVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ7</accession>
    <name>W4TFZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67711">
        <property type="protein sequence ID" value="GAE67711"/>
        <property type="gene ID" value="JCM18909_790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="5"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="290" mass="30687" checksum="45A257D550B57AAF" modified="2014-03-19" version="1">MKTAKVESKDDKDYATNLQSMVDAKCSIIVSVGFLLEKPTLAAAKANPNVKFAIVDDNPANPPENLKPLIFNTAQSSFEAGYLASALTKTGKVATFGGMKIPTVTIFMDGFFSQGVDYYNKQKHKSVQAIGWDVKKQDGQFVPQPNPFQNVSGGKATAQALLNQGADIILPVAGNAGNGALQAVKSSGGKANAIWVDGDGCKTQPAYCSNIITSVFKGMDVAVFDAVKAAKDGKFDNKPYVGSLEDGGTGLSPFHEFDSKIPADVKDELKAIKDDINSGKITITSKAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG15</accession>
    <name>W4TG15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67457">
        <property type="protein sequence ID" value="GAE67457"/>
        <property type="gene ID" value="JCM18909_518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12739" checksum="CB2A6663A13209A6" modified="2014-03-19" version="1">MDPWYSSGKFYGELVKFSNWKTVSINDAAQQVQRSGYPEAYRKHEPLAKAWASALTGHSPSALTCINRSSETTTVQELARTARRALAPKVATQVTGPTVTFTATNRYLCARQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG54</accession>
    <name>W4TG54_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67129">
        <property type="protein sequence ID" value="GAE67129"/>
        <property type="gene ID" value="JCM18909_169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046040">
        <property type="entry name" value="DUF5998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19461">
        <property type="entry name" value="DUF5998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="23799" checksum="A7A98B445F81BB0C" modified="2014-03-19" version="1">MNGRFDMSWRLLDQASSWDDGPVNQSADQARVPLPAALAAEIQSCGFFPELVIDLAETSLAGDEVLDHLLHLEATFDNDEVHRHLTLILRTATRMLIGHTDERAEGGQLQAVTSSESIPLSHVSSVVLTRVVQHPDRFGTDPASTTVEAWLQMTWGAVSRLELEPATCGDPMCTANHGYTGAFSGDDIVIRMSPAADGADQVERLMGFATRMQAVTGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG4</accession>
    <name>W4TGG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carbon starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67503">
        <property type="protein sequence ID" value="GAE67503"/>
        <property type="gene ID" value="JCM18909_566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="64"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="281" mass="30712" checksum="19DD25047CBC7EAF" modified="2014-03-19" version="1">MDTVPPRTYNNSTFPEGLPAVSLSDEERARQQRWTPLRVTIWTLISAIAGLGWWMLAVRRGETVNGIWFVFAAIGSYFIGYRFYAKYIQDKLVHPDNSRATPAEYDYNRRDFVPTDRRILYGHHFAAIAGAGPLVGPVLSAQMGYLPSTIWIIVGVILAGAVQNYLVLVISMRRGGRSLGQMAREELGRFGGIAALIATLTIMLIIVAILLWSSSTPWPPPHGVCGASDSLSPSPCSWASTCVICALAKYLRSRSLASSCSCWPSPRGPGSRTLPLPVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ0</accession>
    <name>W4TGJ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67269">
        <property type="protein sequence ID" value="GAE67269"/>
        <property type="gene ID" value="JCM18909_315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12317" checksum="A5BE4480B6BF884C" modified="2014-03-19" version="1">MGSTGGAIQEETAGMNDNEEDLDSTIRHAKALTWVCVALFVVLDVIGLTAPSQSDPRFVLGAFGGAASFLGIIGAGVWWASLAPSGGPAPWTTVLIVNSISRTMPGAMTGVSRRLSSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ7</accession>
    <name>W4TGJ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67657">
        <property type="protein sequence ID" value="GAE67657"/>
        <property type="gene ID" value="JCM18909_731"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5670" checksum="89565CBDA33DDB66" modified="2014-03-19" version="1">MAAFTEHGPTRSIDFTDMTALTRHGPHQERCGPCHVHGETGLTPTRWWPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN3</accession>
    <name>W4TGN3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA (Guanine46-N7-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67583">
        <property type="protein sequence ID" value="GAE67583"/>
        <property type="gene ID" value="JCM18909_655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="9047" checksum="6B1F22AB95CB0D28" modified="2014-03-19" version="1">MTSRLRPGGLWRLATDWDDYAHWMLEVLSAEPLLKPVDAGPDGFSPRWPERPVTRYENKGLTAGRTIHDLTWRRVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR1</accession>
    <name>W4TGR1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two-component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67946">
        <property type="protein sequence ID" value="GAE67946"/>
        <property type="gene ID" value="JCM18909_1048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="141"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="254"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="347" mass="37218" checksum="F78036DBDCE75CAF" modified="2014-03-19" version="1">MQIIAVVIIVAMSIAELKFTEYLALLEAHPMLALVDLAIVVGFVAAAGETAGLQLTVLTTAFLVGLWVDRLGGAIAILMLVVYFVEMGMRSDTNGASHLVMAFMLVVLWVLALVMRKASDDEALSHKILRASLMATTAAEERAKLATELHDKLAKTIQSVALMTSVIPAAVETNPVSAITAARQAHQMSARAVTELRGVMSGLRNNGTDLVFGEAVIGLVSMWQSAEDRHVQLTIDEDMVLRRPDVQFEVLAALGESLDNIAQHAGACDVDVIVSKEGSTLTVVVRDTGKGFSESELRACQRVGHQRVLDVQRRLVRVGGLADVSSEVGGGTTVTMVVHDEPLEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR5</accession>
    <name>W4TGR5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68160">
        <property type="protein sequence ID" value="GAE68160"/>
        <property type="gene ID" value="JCM18909_1279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="275"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="693" mass="77937" checksum="25BD870FF3361C05" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR7</accession>
    <name>W4TGR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67951">
        <property type="protein sequence ID" value="GAE67951"/>
        <property type="gene ID" value="JCM18909_1053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="147" mass="15941" checksum="EAF4FF8FDC9E72F7" modified="2014-03-19" version="1">MPLVDAVAVSHYGSAKRQKEKPGSVILALHAVRRLPYVTVVYYSVSVDASVSGPLEDYGYLVGRGGAQAHYSGTSVPMVPLSIWGIISCIARLVTFRVARCALASGGKVHRYGKRLPGILHLVGLVLRRCLLMCRGLMSRLLIVFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ7</accession>
    <name>W4TGZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uroporphyrinogen-III methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68046">
        <property type="protein sequence ID" value="GAE68046"/>
        <property type="gene ID" value="JCM18909_1154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="231" mass="23968" checksum="105423F66D99FED9" modified="2014-03-19" version="1">MGTGPGDPNLLTLGAVDAINRAQVIVISCAEHRMLLGSDFLGLRPGVRIVLAGGIDEEAAVLLSQPGTGASTPVDVDEHCADVTATVIDAASQGLEVVRLVSGDPFLDGDIGAEAAAVARADYDVDVVPGVTGMTAVPEYAGLTLHGHDVQLIGDAACQRDIAGHGSNWSDQGSSSSIPRLASLKKSSNTRLNLDAVRMSPRPLSVMARRPGRPLIPSPSVSYHRPLRQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH39</accession>
    <name>W4TH39_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_937</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67847">
        <property type="protein sequence ID" value="GAE67847"/>
        <property type="gene ID" value="JCM18909_937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20274" checksum="5367869712491E47" modified="2014-03-19" version="1">MARSVGIDLGTTNSCVAVLEGGEPTVIPNAEGARTTPSVVAFTNSGETLVGEVAKRQAVTNVDRTVRSVKRHMGEAWTMGVDDKTYKPQQISAFILQKLKRDAEAYLGEPVTNAVITVPAYFSDAQRQATKEAGEIAGLTVDRIVNEPTQPPWHMASTRPTRTRPSWSLTSAVAPSTSPCSISPMAFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG3</accession>
    <name>W4THG3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type sugar transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68231">
        <property type="protein sequence ID" value="GAE68231"/>
        <property type="gene ID" value="JCM18909_1354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14420" checksum="4BAD7773A6C2012A" modified="2014-03-19" version="1">MIIAALYFLAPLWWFLVSATKSNGGLYSGNPFWFHDFSLAENFTDIVHRDGGIYFCWLRNSIFYSLVAGVGAGLISAMAGYALAKYRFRGREAVFNCVLAATLLPIMLLTVRCTSCSRRSVWWTRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL8</accession>
    <name>W4THL8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="4">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_1113</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68007">
        <property type="protein sequence ID" value="GAE68007"/>
        <property type="gene ID" value="JCM18909_1113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="14">
        <location>
            <begin position="43"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE68007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="291" mass="31774" checksum="0C2106B31E72C16F" modified="2014-03-19" version="1">MPDTGLTSQVIEEICAWFDANGRDLPWRRPGTSAWGVLVSEVMSQQTPMSRVIGPWHEWMNRWPTPDDLAEEDSGEAVAAWGRLGYPRRALRLHSCAVTIATEHDGVVPNSYDELVALPGIGDYTASAVVSFAFGGRATVLDTNVRRLIARAESGIANCPTSVTRAERVVADALVPDEDARAAKWAVASMELGALVCTARSPQCEVCPIRDGCRWVIDGRPDNAPARRGQPWKGTDRQCRGVIMDVVRNSPHGVKVQMALSAWPQPDQASRCLESLLDDGLVHRRGNLISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM3</accession>
    <name>W4THM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Competence protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68435">
        <property type="protein sequence ID" value="GAE68435"/>
        <property type="gene ID" value="JCM18909_1573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="38" mass="3935" checksum="0C681A208697851D" modified="2014-03-19" version="1">MNPAPRVILDGPPPIIACMGYHGPIPGIVTAHKDRGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP5</accession>
    <name>W4THP5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-lactate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transports L-lactate across the membrane. Can also transport D-lactate and glycolate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lactate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68316">
        <property type="protein sequence ID" value="GAE68316"/>
        <property type="gene ID" value="JCM18909_1444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003804">
        <property type="entry name" value="Lactate_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02652">
        <property type="entry name" value="Lactate_perm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="3723" checksum="23812972CBF6B759" modified="2014-03-19" version="1">MISPQSLTIAATAIGLAGGESVILRKVFLSSRSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP7</accession>
    <name>W4THP7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68037">
        <property type="protein sequence ID" value="GAE68037"/>
        <property type="gene ID" value="JCM18909_1144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26951" checksum="6FB3FE4EB49E4A32" modified="2014-03-19" version="1">MVGIDPVAADVDRIVDLSAEYGVTVSSIHAPCLLVTPNVWGSDPWGKLDKAAEAAGRLGSRLIVVHPPFRWQRDYAGRFEEGIAELNEKYFPLVFAVENMYPWRTPAGRFAAYSPGFDPTNLSYDHLVLDLSHAATAQMNSRTLVDLWGSRLRHIHLTDGSGTFKDEHLLPGQGSQHAWEVIERAVTGGFDGDIVLEVNTRKFSGEGAGQGARFEALSETLTQTRMAVDRGIFARRSGQAWEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP9</accession>
    <name>W4THP9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67704">
        <property type="protein sequence ID" value="GAE67704"/>
        <property type="gene ID" value="JCM18909_783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10518" checksum="7C00DF0842DA3293" modified="2014-03-19" version="1">MSAASISAGHEDVDRRRWFITIGIGLAVWVAQRLALIVAIASDGPVVSRLTRWDGRWYSAIAAGGYHWPNPMFGHTDPWISDLAFFYRGCQLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR2</accession>
    <name>W4THR2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-amino-4-ketopentanoate thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68475">
        <property type="protein sequence ID" value="GAE68475"/>
        <property type="gene ID" value="JCM18909_1616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="294" mass="31997" checksum="DBBB294BEAACFDD2" modified="2014-03-19" version="1">MDRNFSTCCCAPDTGYFNASLYTPYGIAGIETLGVEIGREVQQRYGRQPDAVVVTHAGGGNITGTTRGLRKVGCDQTQVIAVSVDLTGLHMASDHDFNNKSFTTGHTGFGVPFATWPDRVDVPHNAARPLRYMDGYQLVSQGEVFYMTELLTKIEGLERGPAGNTSLTAAVAMARQMDRDQIVVVQETEYTGAGKHHNSQLSFARSRGIEVRRGDPAGNVPGKAIVIPERLDQVSVHPLDLDKLRHSYLRHASQIVAPEQWGDAELEFLAAETNTTTDDVRLIGTELATHTKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS4</accession>
    <name>W4THS4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycerol-1-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_1179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68067">
        <property type="protein sequence ID" value="GAE68067"/>
        <property type="gene ID" value="JCM18909_1179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="457" mass="48660" checksum="6951F413CC5CD647" modified="2014-03-19" version="1">MSDEIIAAAVAGAGDTDVVEMGRGVLDRAGNVLAEHMCRVRGHNLPALVVADERTWAVAGKAVDAGLRSAGVAACDPLVFPAEPCLYASLDSARTIADRLRALDAETGSAVVPIAVGSGTINDLTKLAAKDVGRRYAVVGTAASMDGYTGAGAPISDNGVKVTMQCVAPQVVIFDLDITAAAPQVMTASGYGDLAAKIPGGADWIIADAAGVEPLDQHVWTLVQSGVRDALSRPDDLRRGDPEAFSGLVEGLILSGLAMQVYDGTRPASGAEHYFSHIWELAHVGTDRNPPLSHGHKVAIGTLAMLAFYEKFLNRDLSSLDVDAAVAAWPQWPAVEVNIRSTFDGALADHAVAETQVKYAEPEELRARLTRVIDGWEDTRTALTRQLVPARDFADQLRRAGAPSRPEDIGLTAADVRATFPKAMYYRSRYTVLDLAREAGWYDELVNEVFSLDGLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI33</accession>
    <name>W4TI33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68192">
        <property type="protein sequence ID" value="GAE68192"/>
        <property type="gene ID" value="JCM18909_1314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="24798" checksum="BD7BB18A026E3B07" modified="2014-03-19" version="1">MPYLTHAEGRSTATASTLMTVYVIANAIAGPTAGILTSRHPIRRGTLIEAMIAASAVAWLIVLVWPGPAPLWMLFLLVICLGISLPGGNVGFDVARTFQPGNRLATATGVAITGGFFFGLLEIEIIGLLLDMLCPGGRYTLSGFRWAMSTQLVLFAIGLAGLEVNQRRLYQIMLTTASPCLPGVRPWHGSGGSSNNVAVKADTQLLKSRAVSARDAASRRSLTIRVRPPVADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI77</accession>
    <name>W4TI77_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68237">
        <property type="protein sequence ID" value="GAE68237"/>
        <property type="gene ID" value="JCM18909_1360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848765" description="Beta_helix domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="256"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="610" mass="63660" checksum="5587AF398BD9F2E3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID1</accession>
    <name>W4TID1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerol uptake facilitator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68526">
        <property type="protein sequence ID" value="GAE68526"/>
        <property type="gene ID" value="JCM18909_1670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="SSF81338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="186" mass="19823" checksum="84EB5264AE19BEC2" modified="2014-03-19" version="1">MGTLILILLGCGVVANNLLPKSKGHANAPGSLQINWGWGFGVMFGVYAAYKTGGHLNPAVTVGLAVAGKDLAPGIPATAGNITIYILAQFAGAFVGAVLCWLAYKQHYDEDCDPALKLGTFATGPEIRNPLWNTITEAIGTCPCAVGHPLRLHPGSENWPPGRRFAHCLHRCLPWWAHRICHQPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG2</accession>
    <name>W4TIG2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68327">
        <property type="protein sequence ID" value="GAE68327"/>
        <property type="gene ID" value="JCM18909_1456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12959" checksum="69F37E1940FE680E" modified="2014-03-19" version="1">MLLLDEPTAGLDPAQRVRFRAVLEHVPDDRVTVVSTHQVDDLTDSYDRVIVLSCGRVVFDGTLRSSWIWRQSVRSVVLKWPTSVWWPTNEAHNAAANCARCLVGAPDGRGLHHGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ3</accession>
    <name>W4TIQ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate-flavodoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68308">
        <property type="protein sequence ID" value="GAE68308"/>
        <property type="gene ID" value="JCM18909_1436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="509" mass="54911" checksum="2FE4BCBAFF773DDD" modified="2014-03-19" version="1">MANSSDSRIRTIADGNTAAASVAYRCNELCSIYPITPSSPMAETADEWSAAGRKNIWGDIPTVMEMQSEGGAAGAIHGALQGGALSTTFTASQGLLLMIPNMYKVAGELTSTVFHVAARSLAAQGLSIFGDHQDVMACRQTGFAMLCSSTVQECHDLTLISQAATMHSRVPFMHFFEGFRTSHELNVLEMLSDDDIRHFITDDLVHAHRERALSPAHPFIRGTAQNPDTHFQAREAANKYYEKVPSIVQSLMDEFAQVVGRQYHLVEYHGDPEATEVIVCMGSGARTIEHTIDHFTPAGTSSVSSSCTCSVPSRSPRSSKPSRRQPVPLPSWTAPRSPARTASPSSSTCWLPYPKLIPAAPEIPCRLSQAAVTGSRQRSSPPVWWPGSSPSSSWRVRVPASPPVSTTTSPAYPCHGNPSTSRIPQRSAQCSTAWVLTAPSVLTRTPSRSSDRTPTPTPRATSSTTLRSPVPRRPPTCVSGPSRLRPPTWSARQGSSVSTPGGSWSRWMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ8</accession>
    <name>W4TIQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactate-responsive regulator LldR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68313">
        <property type="protein sequence ID" value="GAE68313"/>
        <property type="gene ID" value="JCM18909_1441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCD" evidence="4">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12570" checksum="B0AFE6E12EE12821" modified="2014-03-19" version="1">MPLTRATDLLVQMHDAMQPDSFNALDTAFHVALAEAGDNRLMSDLTVAIREAVHLPILEAEHSLIGWEQWRNGLICDHQEMLAAIKNGDPERAAKVTEAHIRNTYDTLLIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR7</accession>
    <name>W4TIR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68323">
        <property type="protein sequence ID" value="GAE68323"/>
        <property type="gene ID" value="JCM18909_1452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5508" checksum="E88F4F65BC6343CC" modified="2014-03-19" version="1">MCLTLPDTLVSIVGIEKVLPSFDDLEVFLKLLPRSATGERMNRTTRCGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ29</accession>
    <name>W4TJ29_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68169">
        <property type="protein sequence ID" value="GAE68169"/>
        <property type="gene ID" value="JCM18909_1288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019592">
        <property type="entry name" value="DUF2469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10611">
        <property type="entry name" value="DUF2469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="12351" checksum="25FCCB81E6200A1D" modified="2014-03-19" version="1">MSAEDLEQYENRMELELYREYKDVVGIFKYAVETERRFYLCNVVDLKVRTEGGDVYYEVSMADAWVWDMYRPSRFVKSAKILTFRDVSIEEIVHPDFDEVPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ90</accession>
    <name>W4TJ90_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HtaA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68607">
        <property type="protein sequence ID" value="GAE68607"/>
        <property type="gene ID" value="JCM18909_1754"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007331">
        <property type="entry name" value="Htaa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04213">
        <property type="entry name" value="HtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HtaA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="25475" checksum="7D1C3DA3D01748B9" modified="2014-03-19" version="1">MQYSGSVHFTGVDGRMDLTLSNPEIVVNNGDDHVIMAVTSKTMAGKLVDYGRITFVDMTGSITQGQNDVAQIAGTNVKLNSQAVDAFAGFYQAGKPMDDIDSSLNLGPQSSRPEPTVAPKPSVTPKPTEAPKPDQNTIMAPQSDAATGAAAGGVPSTGAHKIIRMTPNGGYDFLLITSPTETLHCQQDDSTIRGRGSSSEAHRDRRCRLSDLTSRTRSHAFSESHHGCCELGWNYASCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD5</accession>
    <name>W4TJD5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Barstar domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68652">
        <property type="protein sequence ID" value="GAE68652"/>
        <property type="gene ID" value="JCM18909_1802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="9874" checksum="265963A14B9A0DF1" modified="2014-03-19" version="1">MTVDVQSGSGPEAGGPIGSGILLVDPAHSCDPIKVATAWREAGWRVMHMSGGAALGSVLAGFGHALSFPSWYGHDLDALRDCLADLEGDTAVLWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG6</accession>
    <name>W4TJG6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69100">
        <property type="protein sequence ID" value="GAE69100"/>
        <property type="gene ID" value="JCM18909_2287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="606" mass="66944" checksum="D39CF7E32914E0CF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH2</accession>
    <name>W4TJH2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68911">
        <property type="protein sequence ID" value="GAE68911"/>
        <property type="gene ID" value="JCM18909_2084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10606" checksum="4BD47CE58276D745" modified="2014-03-19" version="1">MNVLRRLIPEERINKKIVSWSILVFAILVSWGAILLNAPVLSFTSICSPIFGMIGCLIPAYLVFKVPPLHKFRSPSLILIIATGILLVVSPFLAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI9</accession>
    <name>W4TJI9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein JCM18909_1735</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68588">
        <property type="protein sequence ID" value="GAE68588"/>
        <property type="gene ID" value="JCM18909_1735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="291" mass="31675" checksum="A81054386206CCD2" modified="2014-03-19" version="1">MSTEQTTKTPRVVIITGISGAGRRTAAHAVEDLGWYVVDNLPPAMLGALVDEIAANNIDRLAVVLDVRSRIMFDALGVAVNALDERGIDPAIVFLEASDETIVRRQESSRRPLPLQQGGHLLDAVALERRMLSDLRAEADLVIDTTSITARQLAQRIDHAFAEGIDEGLAFQVMSFGFKRGVPIDADLVFDVRFLPNPYWVPELRPKTGLSSDVASYVMAQAGATEFIDRVEQLLVGMAPGYLREGKKQVTVAVGCTGGKHRSTAISEELSTRLAARGHRIAVLHRDLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ5</accession>
    <name>W4TJQ5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2191</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69011">
        <property type="protein sequence ID" value="GAE69011"/>
        <property type="gene ID" value="JCM18909_2191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="87"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="34883" checksum="B85AB4374D6CF00A" modified="2014-03-19" version="1">MAETTSQAPRKPTAASRMKPVSRVGDTIFAGASSVIAIALAVIVILMFVFLMKTAAPTLLANTDNFFTSRAWTTDQNPPAFGIQALLWTTVISSLLALLIAVPLSVGIALFITQLAPRKLANPVAFVVDLLAAVPSIVFGLWGGIVFGSSEIVNGLRGAIITTLGWIPIFSEDSSWSSATGTVYLASLVLAIMILPIITAVSRDVMAQTPHDQVEAALALGSTRWEVIKLAVLPHSRSGIISGAMLGLGRALGETLAVTLILQTMSPMALKQNLNLSIFVGGETFASKIAGNFSEAISDPTSLGALVASALALFVITFVVNATARLIAAKGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS0</accession>
    <name>W4TJS0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Respiratory nitrate reductase gamma chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_2212</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69031">
        <property type="protein sequence ID" value="GAE69031"/>
        <property type="gene ID" value="JCM18909_2212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="237" mass="26903" checksum="2D2FCD9E704A1E15" modified="2014-03-19" version="1">MNTNLLVWLVLPYLSIILLIGGMIWRYRTDQFGWTSRSSQWNEPSILRWSSPLFHFGILFVFLGHVLGLVIPQSWTYSIGITEDTYHVMATVLGGAAGLAALVGLLGLLYRRFITKSVRLTTTTMDIVTYVLLTLAVTLGCWATVHQQMIVGGYNYRDTISPWFRSIALFQPRPELMATVPLDYKIHVMAGMILFSVWPFTRLVHVVSAPVSYPTRPYVVYRSKNGHLGSSSRHYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS4</accession>
    <name>W4TJS4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Respiratory nitrate reductase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69036">
        <property type="protein sequence ID" value="GAE69036"/>
        <property type="gene ID" value="JCM18909_2218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin" evidence="1">
        <location>
            <begin position="3"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="635" mass="70015" checksum="B06249A46E3D5A19" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY7</accession>
    <name>W4TJY7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Abhydrolase_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="proac-q6a6l8">
        <property type="family name" value="Abhydrolase_9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69111">
        <property type="protein sequence ID" value="GAE69111"/>
        <property type="gene ID" value="JCM18909_2299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027787">
        <property type="entry name" value="Alpha/beta-hydrolase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10081">
        <property type="entry name" value="Abhydrolase_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_9" evidence="1">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17813" checksum="06250E704FDD7E80" modified="2014-03-19" version="1">MSAVEYLTRGDCATATMQYSYLGSVGAFLLDRESPKQGARALFTVIYNYWKTLDPQTRPKLYTSGVSLGSFGGQAAFASINDMVSKVDGAVWVGTPGFTPIWKDLEKHRREGSPEIVPVIDNGRVVRFIGNPREITHDHWGAPYPPGVHTPALPMSSILQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK44</accession>
    <name>W4TK44_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical nudix hydrolase YeaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68897">
        <property type="protein sequence ID" value="GAE68897"/>
        <property type="gene ID" value="JCM18909_2069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12453" checksum="E06AD1D7AD0A55F5" modified="2014-03-19" version="1">MAASGSDVTTVIATWSGAGTVGVVDPAEVAMVQRVRLADLANPAARATTRHPSGYRGPAFVLPDIFVWGFTAHVLDALLDRGGWSRPWDRERMVKIPEGYLGARRLPEGTTPNDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK56</accession>
    <name>W4TK56_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68813">
        <property type="protein sequence ID" value="GAE68813"/>
        <property type="gene ID" value="JCM18909_1976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="231" mass="23625" checksum="B1CA131F8002CE6E" modified="2014-03-19" version="1">MSNAREIREPLAWTVIVVSVGFLVAFVVRVVKMLTHDHSGLFGTARSLSGSSLGIGMILLLLAAVLVCRFIHPATPHAELLGKVSACVVAVAAGCDLVLALLSPIHSPGGAFGAVLGLFGDLLAIAIKVLAAWVLLVLTRPEAASVQDNEDPAEPEAVLDGSAGCPVIADEAEGPAHDDKVSWPVGVGAVWTRAGDAASGAEASSWDQNDAGGNWTTEAPGPSRDEPGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK61</accession>
    <name>W4TK61_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68818">
        <property type="protein sequence ID" value="GAE68818"/>
        <property type="gene ID" value="JCM18909_1982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="17610" checksum="4FBD56B6D45488E1" modified="2014-03-19" version="1">MSVTALAGRGPFTPDGADEIDIDPRSTIQVDLSKALAGEGVGLRLSADDPVIARLFVQGKPGTTDNALVSPGGSSKVLEQTVGAAGTLELSNPGREAVTFSGELTGIHGEKTAIEGTVPTGSTWSGKVPAAGHLHIVGSAPLIGGVISASGLAVLPLEAVAPMTNGRSVDVDPQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK87</accession>
    <name>W4TK87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69365">
        <property type="protein sequence ID" value="GAE69365"/>
        <property type="gene ID" value="JCM18909_2574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9747" checksum="568A947F22C19F44" modified="2014-03-19" version="1">MVPILSSPLREYTFHPILATQQPLSHRKVPTRQQHPPKFTVSANDFGVRRPLPAGRTMVLLTYRWKDGMTRMSTMTRLLKKWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD4</accession>
    <name>W4TKD4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidoglycan N-acetylglucosamine deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68977">
        <property type="protein sequence ID" value="GAE68977"/>
        <property type="gene ID" value="JCM18909_2155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12691" checksum="662E87F672A89800" modified="2014-03-19" version="1">MAQSRAILGSNYFSSAFRYSGGHMSWTNLSQADAALAKRGVGWIDWNAMSGDADAQRPTTVLGYLEMVKKSIKESNNPNVVVILNHDTYGKQMTAKAMPSILAWLKSQGYEFGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG4</accession>
    <name>W4TKG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69017">
        <property type="protein sequence ID" value="GAE69017"/>
        <property type="gene ID" value="JCM18909_2198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="8594" checksum="D3CDB7E0D3450A05" modified="2014-03-19" version="1">MFWTLGDLSRASWAQGWTSIVVAVVLSILCSYCAPWLDALASGDSTATAVGIDPAMIRVLLLVPVSAGVAIAVAISGGIGFVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH9</accession>
    <name>W4TKH9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Respiratory nitrate reductase delta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69032">
        <property type="protein sequence ID" value="GAE69032"/>
        <property type="gene ID" value="JCM18909_2213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11507" checksum="90BDC3A8AC2C69CD" modified="2014-03-19" version="1">MRSAGFELDHANELPDYLPVVLEFSARASEGDTLLRANREALEVMRSALVTASSPYAHLLEGLCLILSPLDEKTLARYQKLISQGPPVEMVGLAATDPVSTLGRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK3</accession>
    <name>W4TKK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunits gamma and tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68938">
        <property type="protein sequence ID" value="GAE68938"/>
        <property type="gene ID" value="JCM18909_2113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="238" mass="25829" checksum="69F471FB49B5F298" modified="2014-03-19" version="1">MPEPGMENEAVEPEVFEQDGPDLFGDEESPRPVMPPDEATPDDDLPSDPCDPGLLDGPETPEEPDGLETDEDEEDGADVIERVQELIGEAPDSNPDDDLPELPLALYRRYRPETFDEVIGEDHVIEPLKRAILNNRVNHAYLFSGPRGCGKTTTARILARALNCEQGPTPTPCGTCQSCRDLACGGPGSIDVIEIDAASHGGVDDARDLRERAFFSPQYIRVTRSTSSMSPHGHPAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR3</accession>
    <name>W4TKR3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69008">
        <property type="protein sequence ID" value="GAE69008"/>
        <property type="gene ID" value="JCM18909_2187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="22434" checksum="DB1C4163D96E83A2" modified="2014-03-19" version="1">MARGRRRRSIENATASPEEIDGAFWMPTDQALERLTYPTDVQVLEEALDLPSTSTIILVRHGKAVSRKEWNSRKRHGKDATRPLERRGRRQAKALADLLSAFRVARLASSSSTRCMQTLQPYADTIGAQITGLDALSEETHEADPHKAASAMRKNYWPRVGRPQPTNCHLWPSSGTADDARSPWRGESPYVNCGVPDCSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS5</accession>
    <name>W4TKS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADPH-dependent mycothiol reductase Mtr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69023">
        <property type="protein sequence ID" value="GAE69023"/>
        <property type="gene ID" value="JCM18909_2204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="40" mass="4181" checksum="FD75458DDDCCD2F8" modified="2014-03-19" version="1">MIHTSDTIMRLAELPQRLVILGGGLIAAEFATSSLGSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU7</accession>
    <name>W4TKU7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69053">
        <property type="protein sequence ID" value="GAE69053"/>
        <property type="gene ID" value="JCM18909_2235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="268" mass="28613" checksum="7B1A0173C752CD94" modified="2014-03-19" version="1">MIWKLHNRGVLEPGEVVAPDERLGWGRTIGLGAQHVVAMFGATFVFPVLMGLNPQLAVMMSGVATLVFIFVTQHEVPSYLGSSAAFPGVATAIYASGGKPNDVSGALLCVGLTLLICGIIIQVAGSRVVHKVLPPTVTGAVVMLIGFNLAPVVAKTYWPTDQWTALIVMLLVIALSVGRVASCPGSLSFWLWLSAICCRGSKISYLAHCTTPMAALPRGWTGRRSTAPRGSACLRRRTWTTGNTCLRFTTDLITHQPMSSDFTCRPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ0</accession>
    <name>W4TKZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-6A synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69630">
        <property type="protein sequence ID" value="GAE69630"/>
        <property type="gene ID" value="JCM18909_2870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043819">
        <property type="term" value="F:precorrin-6A synthase (deacetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11643">
        <property type="entry name" value="Precorrin-6A-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012797">
        <property type="entry name" value="CobF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036525">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02434">
        <property type="entry name" value="CobF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="260" mass="28999" checksum="E8A479B37F68FFF2" modified="2014-03-19" version="1">MSRRLDLIGIGPGNPDWLTLAAVDAIQHLDVLFVVLKEHDVDDLVEFRREVLRRHRPDADSDGLHIVELQDPPRPWKTAENYKAAVAKWRRQRLDQWAHAVADNLADGERGGFLVWGDPGLFESTLAIVKKLIVAVDADGGVPIELNVIPGISSSLSLASRHQIPLNRQGRALQISPARLLANGMPEGVDDVIVMLDGRQTFSLIDPTGIDIYWAAYIGTPDEILISGDLAEVREEIRSARADAEKRLGWVFDTYLLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL13</accession>
    <name>W4TL13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68854">
        <property type="protein sequence ID" value="GAE68854"/>
        <property type="gene ID" value="JCM18909_2019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="305" mass="34282" checksum="7D9996D1E4E1BD99" modified="2014-03-19" version="1">MSTSNQTWWLKELFNGLSLVAALIMLVPLTKLLVTIPWFAAARTDISPAPPKPKGKSAVIFWAIFVISAAVACVTFIPLSVASQHIFSTAANKQNGWFFPGRMVNGVVLWSLVNGLLGLILLWISHAISKKHGDDEAKDWGVRMNWTQTGRTLALALLVIVIFYTILAAIYGFFHIDYRLFVVAARPLTKRWFLIALTYVPALFLFFFSNSLRVNTSMRFNNQHCWANWLIIALANSIGLAAIFVIQYVTLFSTGTVFWTATWLYVNMLQSLLPMMVVLPLFNRAFYHATGRVWLGPIVTTTIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL55</accession>
    <name>W4TL55_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt-zinc-cadmium resistance protein CzcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2364</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69173">
        <property type="protein sequence ID" value="GAE69173"/>
        <property type="gene ID" value="JCM18909_2364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10592" checksum="6FF8732B0C7BEBED" modified="2014-03-19" version="1">MITEIITAVISGSLALLSDAGHMLSDIGAIAIALWAARLTRRRPQGSWTWGWKRAEIMSAAVNGVTLLVVAILVGIELFDAWSLPLPLAEGWLWSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL63</accession>
    <name>W4TL63_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69471">
        <property type="protein sequence ID" value="GAE69471"/>
        <property type="gene ID" value="JCM18909_2690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="301" mass="32602" checksum="73E73382B02E4956" modified="2014-03-19" version="1">MMAVDGSVVKVRDGWQATGKPWVHDTERYERISQARREEQQAMLGYERSRTCRMTLLTGQLDDPSTSPCGRCDVCAGPWYSVEVDQSAAVRAVQSLNRVGVPVEPRIAWPAGMDALQVALKGRISAEEIAAEGRVIARLSDLGWGGALRDLLRSDANGVPIDAEITPALAKACLRVLAEWDWEQRPAAIVRIPSITRPHLIDSLASGIARVGHLQDLGWLDLADGSARLQSSTNSAYRLRDVHDRFSVGPGLMSRLSHLGGASVLLIDDVISSRWTMTVAARSLRRAGSGPVLPLALALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL65</accession>
    <name>W4TL65_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69183">
        <property type="protein sequence ID" value="GAE69183"/>
        <property type="gene ID" value="JCM18909_2374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6978" checksum="754E4C3AD47567AB" modified="2014-03-19" version="1">MWECPRCGAEALRSDGTDPQRKKQKPQRTHWDMLTERRSIPELEELLAERLDEIRKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB8</accession>
    <name>W4TLB8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68939">
        <property type="protein sequence ID" value="GAE68939"/>
        <property type="gene ID" value="JCM18909_2114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12981" checksum="E54730586B1D8A63" modified="2014-03-19" version="1">MDDQRRIITTDRAGSIWAGITWFSLLLFIVAGIIGMMAQTMLPANLGYPQLHDSGVPTWLTWTVVGLDVVAFFIPPLVTTSCGRKAKRLGHPVRSAVQISWATFTVVTVISFLLVFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC0</accession>
    <name>W4TLC0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6531 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68944">
        <property type="protein sequence ID" value="GAE68944"/>
        <property type="gene ID" value="JCM18909_2119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6531" evidence="1">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="825" mass="89724" checksum="016E2FB1EB394944" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF3</accession>
    <name>W4TLF3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2467</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69268">
        <property type="protein sequence ID" value="GAE69268"/>
        <property type="gene ID" value="JCM18909_2467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="132" mass="13812" checksum="EF78EA84A17BA321" modified="2014-03-19" version="1">MFLNCSVWRQFAENVAESLSKGMRVIVNGNLKARSYEDRNGNRRTSYEIDVIEIGPSLKFAAAKVSRNQSSVGGNWGGNSAGGQGGWSGGNGGQGGNWGGNPGNQGSYNNGDANRGGGVDPWASAQTDEPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH1</accession>
    <name>W4TLH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69830">
        <property type="protein sequence ID" value="GAE69830"/>
        <property type="gene ID" value="JCM18909_3086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5720" checksum="6DD667CE9A2B769C" modified="2014-03-19" version="1">MSVTTTPISARATTPSPRLRRSPRLIVIGVLCACLGGLGELLPGTAPLMPTKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH8</accession>
    <name>W4TLH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69009">
        <property type="protein sequence ID" value="GAE69009"/>
        <property type="gene ID" value="JCM18909_2189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14669" checksum="6F6557A4A7BAFB7A" modified="2014-03-19" version="1">MAAGPIAVVYNIDGVKDLTLSTATLAKIFSGAITNWNDDAIKKENPKAKLPSAQIEVFYRKDESGTTDNFTKFLNKAAGDIWTEKHSKTWKGAGKGADKSAGIAQAVKSTKKLDLVRRVVLRYKEQPRHGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI2</accession>
    <name>W4TLI2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosine/purine/uracil/thiamine/allantoin permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69298">
        <property type="protein sequence ID" value="GAE69298"/>
        <property type="gene ID" value="JCM18909_2498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="313" mass="34140" checksum="ACAD4355B395F415" modified="2014-03-19" version="1">MSSTIGLLGLLYVAVRLFQVSSFGPQLTDVHFSVAPFLLSIALAAGWQLTYAPYASDYSRYLPRDTKFGRAWFGPFAGSVLEATISMTLGVFIAAAGGQAFIGDQVGFMGNLAQNRVLAILVFISIVIGKLTINTLNAYGGVMALSTALSGFTGKSSVSPKTRFGFVIGFNVVVVLTALAASSDFLQVFKSFILTLLMFFLPWSAINLLNYYFICRRHIDIPALFTPRGRYGKLHWTTIVVYLLGVIVQIPFISQAFYVGPVATAMGGADISWLVGLVVTALVYFQLGRRAFDYPVEMIYPKDVELDPKVVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM8</accession>
    <name>W4TLM8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69890">
        <property type="protein sequence ID" value="GAE69890"/>
        <property type="gene ID" value="JCM18909_3155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9613" checksum="6D626D46F8DD4FEB" modified="2014-03-19" version="1">MVTHFSIAEASHRQIVTRLDGREVQHGNTDQMVHTIPKLISYISSFMTLLPGDVILTGTPAGVGPMELGQRVEVEIEGIGTLTNTVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS8</accession>
    <name>W4TLS8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="12" type="ORF">JCM18909_2333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69144">
        <property type="protein sequence ID" value="GAE69144"/>
        <property type="gene ID" value="JCM18909_2333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE69144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="22550" checksum="056C49739240C07D" modified="2014-03-19" version="1">MSGTQRRGGGAGGERRGRDNRRGQNDRNRNQNEYLERVVAINRVAKVVQGGRRFSFTALVVVGDGEGSVGVGYGKAKEVPAAIAKAVEEAKKHFFKVPLVGRTITHPVIGEKAAGIVMLRPASPGTGVIAGGSARAVLECAGVHDVLAKSLGSSNAINVVHATVAALQQLEEPEEVARRRGKSVEEIAPAAMLRARKEADEAAAAARMEEKAGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY5</accession>
    <name>W4TLY5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoserine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69761">
        <property type="protein sequence ID" value="GAE69761"/>
        <property type="gene ID" value="JCM18909_3012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="15077" checksum="7ECBEE1389C2D5A2" modified="2014-03-19" version="1">MTNSRADQTLNTPALATLAMLEAQCRWLLEQGGMAWAASRTASTSGILYRWAEDNPLTIPFVADPALRSPVVVTIDIDESVDAAQLCARARDNGILDIEPYRKLGRNQIRVATFSSIEPSDVEALTACLDWLLENRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM17</accession>
    <name>W4TM17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-keto-2-deoxy-D-gluconate-6 phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69572">
        <property type="protein sequence ID" value="GAE69572"/>
        <property type="gene ID" value="JCM18909_2805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="4815" checksum="FD7315B9EF6C7F06" modified="2014-03-19" version="1">MKSVVMASGLGADTSWTWLKLPAVDDMERVVRATSLPILLLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM21</accession>
    <name>W4TM21_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsN</name>
        <name evidence="6" type="ORF">JCM18909_3305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70025">
        <property type="protein sequence ID" value="GAE70025"/>
        <property type="gene ID" value="JCM18909_3305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00537">
        <property type="entry name" value="Ribosomal_S14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023036">
        <property type="entry name" value="Ribosomal_S14_bac/plastid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12522" checksum="5A58A58565A79892" modified="2014-03-19" version="1">MSSRRPANGQKKSKIVAQKKREKLVAQYTERRAELKAIMKCPTASLDERMEASRKLSRLPRDSSPVRLRNRDQVDGRPRGYVGKASVSRIRFREMAHRGELPGITKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM42</accession>
    <name>W4TM42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69468">
        <property type="protein sequence ID" value="GAE69468"/>
        <property type="gene ID" value="JCM18909_2687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD" evidence="1">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13748" checksum="7AAD389B99C21D15" modified="2014-03-19" version="1">MAILRRLVGRNNADFHPGQWEIIEALVAHHRRALVVQRTGWGKSAVYFVATLLQRAIGSGPTLIVSPLIALMRDQVAAAKRAGVRAAAISSANATEWPEIAQRLEADDLDVLLVSPRTPGQSHIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM49</accession>
    <name>W4TM49_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69607">
        <property type="protein sequence ID" value="GAE69607"/>
        <property type="gene ID" value="JCM18909_2844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="15219" checksum="6935DDD3DF8568C8" modified="2014-03-19" version="1">MDSTSRSDLPSKIVMRDNTEGFNQRMDFALRDGKVYGRFQSENQWRHIDTPSCLDGHISAISVNDAMLVAVDSNGWVYSLNNLLSSPKDWGWFRAWGIPFWFGRGSSSTTTTKVGGPCPHRQPDRPHLSRCRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM62</accession>
    <name>W4TM62_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69821">
        <property type="protein sequence ID" value="GAE69821"/>
        <property type="gene ID" value="JCM18909_3077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849146" evidence="1">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="10488" checksum="799EFEBA44A8AF0E" modified="2014-03-19" version="1">MWPVVLLVVVAVIQTAVVLQARATVTEAARAPVRVQALRGSHAGEAEATARDVARTSKVTDVTVTVSTTDSLVRVDVEGRASALFGAAVAVRGHAVAVEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM72</accession>
    <name>W4TM72_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70080">
        <property type="protein sequence ID" value="GAE70080"/>
        <property type="gene ID" value="JCM18909_3366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10500" checksum="AF203957BC49A456" modified="2014-03-19" version="1">MNRYLPDVRLGDIENLVVESLRDYYLEIDDIRLSNMIVNIAICVQRYSFPIEDNAAIDLMMSNQSEMLCDQLLVGLGKLYPERPLSSADDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM87</accession>
    <name>W4TM87_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LytR_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69518">
        <property type="protein sequence ID" value="GAE69518"/>
        <property type="gene ID" value="JCM18909_2743"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_C" evidence="2">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14528" checksum="777793178E45D2AA" modified="2014-03-19" version="1">MTSDERRHYLRMAGTPLTLLALVLLIAVAIRAGWKAVSAPIPPPPLTPCVNQDVNGELTTQDVTVSVYNSGHTRGLAGSVSKQLANVGFVIDSVSNRQPSVKKVTIIGQDAKKSRGGAGCRLFPRGGREVGSQARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA1</accession>
    <name>W4TMA1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69319">
        <property type="protein sequence ID" value="GAE69319"/>
        <property type="gene ID" value="JCM18909_2520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="205" mass="21761" checksum="B5513B158BE9F37B" modified="2014-03-19" version="1">MGEPRIIDTADLDDGVTIGDGSSIWHLSQVRSEAVLGQNVVVGRGAYIGEGVHVGDNCKIQNYALVYEPAKLEDGVFIGPAVVLTNDHFPRAINPDGSLKSADDWEQVGVTCKRGCSVGARSVCIAPVTIGEWATVAAGSVVTKDVPAYALVAGVPARRIKWVGRSGFPLDPDGENKWIDSRTGDRFVEDPATDTLTLVSEDEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC9</accession>
    <name>W4TMC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type I restriction-modification system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69692">
        <property type="protein sequence ID" value="GAE69692"/>
        <property type="gene ID" value="JCM18909_2941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022625">
        <property type="entry name" value="TypeI_RM_Rsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12008">
        <property type="entry name" value="EcoR124_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EcoR124_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="22107" checksum="A24B88B506A36BA1" modified="2014-03-19" version="1">MDLWDEFRRDQEGEGDKEKIDDEDVVFEIELIKQVAINVDYILMLVEEHCKECGNGKDVELPPVVSRAIDANPNLRSKKDLIEEFVAKMSVDTAVNSQWEQFINNKRNQELDKIIEQENLYSEKTHEYMDNAFCDGELQTTGIAITKVMKPMSRFGAKNNHAEKKKSRVIKALRVHFDRFRGLGLGEDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD2</accession>
    <name>W4TMD2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Epi-inositol hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69568">
        <property type="protein sequence ID" value="GAE69568"/>
        <property type="gene ID" value="JCM18909_2801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016823">
        <property type="term" value="F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="2">
        <location>
            <begin position="230"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="331" mass="35711" checksum="4B765C8E4D242DE6" modified="2014-03-19" version="1">MTEQTVRLSVGQAIVRYLTHQYTERDGVERRFIRGVFGIFGHGNATGLGQALLQNEVAPDDEEGRLEYWMGRNEQGMVHTCSAYARATNRLQALAATASIGPGSLNMVTGAALATTNRVPVLLFPSDIFANRAPDPVLQQLEDPTNPDVSCNDAFRPVSKFGDRVNRPEQLMVSLPRAIRVLTDPVDTGAAVICLPEDVQTEVYDWPVSFFVKKVWYIDRRLPDRAALVRAAQAIRAARCPLIISGGGTIYSEASQELRDFASATGIPVADTQAGKGAINWDHPCAVGGVGATGSDSANALAAQADLIIGIGTRYSDFTTGSQTAFKKIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD5</accession>
    <name>W4TMD5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70145">
        <property type="protein sequence ID" value="GAE70145"/>
        <property type="gene ID" value="JCM18909_3441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12984" checksum="C2A7B347AFD6B60D" modified="2014-03-19" version="1">MWSEDAICDGFGHPVELDRIRPVQALLMNRASFEAQREAAPVERPFLISRSGPLGLQRYVQTWSGDNSTSWRTLKYNTRMGVGMSMSGLVNFGHDVGGFAGTARPSPELFLPAGWPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM3</accession>
    <name>W4TMM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69956">
        <property type="protein sequence ID" value="GAE69956"/>
        <property type="gene ID" value="JCM18909_3229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18252" checksum="DCF83D9932653EAB" modified="2014-03-19" version="1">MASNLRELRERRNSVATTKKITRAMELIASSRIIKAQNTVKAAGPYSLELTRALSAVAAHTHEEHPLTSMNPDPKRSAVLVITSDRGLAGAYSSNVIRTAEELTTALQPKQEIATYLCGRKAVQYFEFRGRKVDHLWSGFSDSPSYRDAKDIADHLIEDFFATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMV3</accession>
    <name>W4TMV3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70046">
        <property type="protein sequence ID" value="GAE70046"/>
        <property type="gene ID" value="JCM18909_3329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10453" checksum="91C4A6B0F7E863DD" modified="2014-03-19" version="1">MYVPEQEAVVACRSIARSTGLLLGGSSGSAIAAIARVANDICPEDSVIAICPIWVKKYLDTIYDDIWVSTHFPELKPIVTHDNEIHEEIRWDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW4</accession>
    <name>W4TMW4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69529">
        <property type="protein sequence ID" value="GAE69529"/>
        <property type="gene ID" value="JCM18909_2755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="148"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="247" mass="26756" checksum="867A34004C352455" modified="2014-03-19" version="1">MTILRPADLRGLAALLGSQEPRAVVPPCWHWGLLLDPVVPGNLDEDGYVIGSPITPEPGMMRMFAGERVRTISPLALNSETSRTTKVASVTDKEGRRGLLHFVTMRSTWSQGDRDCLVDEQDYVFMPTHSAGPSPEGAGHTGGNGFLVTEPLLVTFSALTANPYRIHWDRDFCRQAGHDGLVVHGPLQALLMAQAFADTGADFTGKQFSYRFRAAVTAPTRLTVGIKEDEAKVRRPDGTVTATATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN56</accession>
    <name>W4TN56_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70161">
        <property type="protein sequence ID" value="GAE70161"/>
        <property type="gene ID" value="JCM18909_3457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10391" checksum="C96E06286C5F6FA6" modified="2014-03-19" version="1">MIIRIVGEGQWQVPDTEMGHLNRIDARVEHAIETTSQNELTEALTELVTTVRTVGTPIADDNIIDSDLIVPDVSATIEEVSVWLSENPAGDGLIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN75</accession>
    <name>W4TN75_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="17">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">murB</name>
        <name evidence="19" type="ORF">JCM18909_2909</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 17">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 17">Belongs to the MurB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="17"/>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69664">
        <property type="protein sequence ID" value="GAE69664"/>
        <property type="gene ID" value="JCM18909_2909"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 17" id="KW-0132">Cell division</keyword>
    <keyword evidence="12 17" id="KW-0133">Cell shape</keyword>
    <keyword evidence="16 17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0274">FAD</keyword>
    <keyword evidence="9 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 17" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 17" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="48"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GAE69664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="35741" checksum="FDF4369101A0C5CA" modified="2014-03-19" version="1">MSTTVIGPYEDDDPTEACSTIHHEVIGTTTCLSGGEDVPLASLTTLKVGGPARHLVIATTHDELLATVRDCDRRGEPCLVLGGGSNVLVGDNGFDGTVVRVATSGLSAEVSSCGGALVTVAAGQVWDDFVVHAIEQEWIGPEFLSGIPGLVGSTPIQNVGAYGVEVGEFIARVRTWDRLDDTQRTFTAGQCDFGYRSSRFKAEPDRYVVLDVTMQFNLGTRSLPVRYAELARRLGVEPGERVDTSQVRETVLAVRAGKGMVLNPNDHDTWSAGSFFSPTLGVSGSGSGGAPAFAQPDGRVKTSAAWLIDTPVTVRGSKWLRMRRRVCRLNMSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH7</accession>
    <name>W4TNH7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase component BioM of energizing module of biotin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69938">
        <property type="protein sequence ID" value="GAE69938"/>
        <property type="gene ID" value="JCM18909_3208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="20"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17469" checksum="6BE2D86578DB70A5" modified="2014-03-19" version="1">MSQLVMSTPVADVELSLRQRIRNRLERHEAAMQILADQGLEAVAGRSVHALSGGERQLVSLASVLAVEPSVILADEPTTLLDLRNREMVRHAFERLDQQILCCTHDLELAASFDRVLAVEDGRIVDDGDPGEVIADYRARMMSGQGGVVPRRGGQDKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM7</accession>
    <name>W4TNM7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70142">
        <property type="protein sequence ID" value="GAE70142"/>
        <property type="gene ID" value="JCM18909_3438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23996" checksum="786683945F5F09C3" modified="2014-03-19" version="1">MMLRPQDTATRDTKCLSGMWDFAFDAEDRGQTEGWFTRPLPTRTEMAVPASYQDLSTDPAARNHVGPVWYQREIRIPHGWTDDRVVVHFESATHAATVWVNDVEVVRHVGGYLPSKPISPIMSARAKKCRLTVRVDNRLSFQTIPPGVIVDSPEGPKQTYWHDFFNYAGIHRDVWLCRRPQTHVEDVTITTDIDGNDGIVTWSVVSHDAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR7</accession>
    <name>W4TNR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose binding module</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70371">
        <property type="protein sequence ID" value="GAE70371"/>
        <property type="gene ID" value="JCM18909_3687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18037" checksum="E038F5B61F980B88" modified="2014-03-19" version="1">MADITILRADITTLDVDAVVNAANRQLAGGGGVDGAIHRAAGPELSQACRKLRDTTLTDGLPTGQSVATTAGKMPAKWVIHTVGPVWAKTIDKSDQLASCYRTSLHVADEIGARTIAFPTISAGVYGYPMDEATRITVETCQQTVTKVETIYLVAFNAEAEAGYRAALGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP20</accession>
    <name>W4TP20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70456">
        <property type="protein sequence ID" value="GAE70456"/>
        <property type="gene ID" value="JCM18909_3783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7669" checksum="BC799766F7B2F1F6" modified="2014-03-19" version="1">MAKADPDMILIYDYKTPSVDQKIKTLKSIPALKDTKAVKNNAFPVISLSLAQPGPRSAEGIEQLAKQFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP33</accession>
    <name>W4TP33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70173">
        <property type="protein sequence ID" value="GAE70173"/>
        <property type="gene ID" value="JCM18909_3470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="403" mass="44016" checksum="7DB455C7699D5D9D" modified="2014-03-19" version="1">MRFLNEQPNYDLTYNDVFMAPNRSSVGSRMNVDLTSTDGLGTPLPLVVANMTAISGRRMAETIARRGGIAVLPQDIPADFVARSIRRVKDAHTRFDTPVTVNPTTTVGEAMNLLNKRAHGVVLVVEDHRPVGLVSPIEAEGVDRFAQCHEVMTTDLTLVGPQASPDDVFQTLAERHQKVAVAVDENGLLVGIMTSRGALRTEIYRPAVDPEGHLMIGTAIGINGDVAERARNALESGSDVLVMDTAHGHQDQMIRAIEIADEARTAFETKTGRRVPSSPAISLPAAAPSICWRRVRTSLRSASDRAPCAPLGCRPGWGVRSFRQCWSAPRLLPRLMVPSGLTVGCVTPAMLLLPCCRRRIGHDWLVVRGYPRIDRGHAHRPRWPDVQGVLRHGLGSRRASPYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPG8</accession>
    <name>W4TPG8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70308">
        <property type="protein sequence ID" value="GAE70308"/>
        <property type="gene ID" value="JCM18909_3620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850865" evidence="1">
        <location>
            <begin position="30"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="255" mass="27558" checksum="9E19C790B20D9981" modified="2014-03-19" version="1">MSIPRLPIAVVACLAMALAGCSSGSTSKGDDAKSSSEVTLTNCGNKVTYPKIAQRLYANDGNIIAMALSAGAAKQIAAVSSLGDDKTILAAKYGSHVIDNLHEAVKGYPTLESIIANKPDVVVAGWNYGFSEESNLTPDKLHERGIGSYLLSESCRQKGSEKARGVMQPWDAVRTDLSNLAKLTGNEPTGKRRSRTSTTGLTLLTRLRRLRKPLWFCCSTQPRTRSSLAEIRADRRPSSMLRVDRMQPTMSTIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPG9</accession>
    <name>W4TPG9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70104">
        <property type="protein sequence ID" value="GAE70104"/>
        <property type="gene ID" value="JCM18909_3394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4151" checksum="ECE8F56C86A4B310" modified="2014-03-19" version="1">MQGAVWGIDSFDQWGVELGKKSLRCRSPRLCPVTMTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ00</accession>
    <name>W4TQ00_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Corrinoid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70458">
        <property type="protein sequence ID" value="GAE70458"/>
        <property type="gene ID" value="JCM18909_3785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9168" checksum="CC2461262313EB35" modified="2014-03-19" version="1">MSAGTLILTGTAVSALLSAVNNFMVLTSPDPQLASQVLFWSLGGFGAAKWENLLFPAGVLAIGIILCLAQARTSIPCLLVRKVRVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ07</accession>
    <name>W4TQ07_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70617">
        <property type="protein sequence ID" value="GAE70617"/>
        <property type="gene ID" value="JCM18909_3971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="19746" checksum="85D40629547A08A0" modified="2014-03-19" version="1">MTSWVFAGLVLAAFMAGWVNAVVGGGGLIMLPSLLVGLPTETPVATIVGTNKAAQVVGNLTAGVGYLRKQRPDWRMFLWAAVLAGLGAVLGARIVTYMSRAVYTPILLVVLVIIGIYTWRRPSLGADHNGEGGKHPVLVPIIGLFLGCYDGAIGPGVGTFWYLRTSLLAGIRSLKLPEWRRFATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ09</accession>
    <name>W4TQ09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70468">
        <property type="protein sequence ID" value="GAE70468"/>
        <property type="gene ID" value="JCM18909_3795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4280" checksum="D56B684ACDE3A617" modified="2014-03-19" version="1">MGAQGMGERHQSGRFSSDRTIRDYAEQVWKLEPVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ22</accession>
    <name>W4TQ22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70329">
        <property type="protein sequence ID" value="GAE70329"/>
        <property type="gene ID" value="JCM18909_3643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041856">
        <property type="entry name" value="NAD+_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11664" checksum="BEEC57A3CEF6EF3C" modified="2014-03-19" version="1">MRPSRIIFLSHHAWRDASVGSWPPGFRDEDRHSYDLSAIKDWTRLFLRRFVGNQFKRSTLPNGPKVVTGGSLSPRGDWRMPSDAVVRAWLDDLETVPDERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ46</accession>
    <name>W4TQ46_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70508">
        <property type="protein sequence ID" value="GAE70508"/>
        <property type="gene ID" value="JCM18909_3836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18287" checksum="0BDC7CC776C9A05B" modified="2014-03-19" version="1">MRVVSIVGARPQFVKLAPVAKAFAAKGIDHKIIHTGQHYDVNMSDSFFVELGIPNPDLHLGVGGGSHGVMTGRMLEQLDPVLEDMDPDWVLVYGDTNSTIAGTLSAVKMHLPVAHLEAGLRSFNRRMPEEHNRVLTDHAADLCLAPTEVAMGHLTDEGWPPVQFSSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQG4</accession>
    <name>W4TQG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysozyme M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_4015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70648">
        <property type="protein sequence ID" value="GAE70648"/>
        <property type="gene ID" value="JCM18909_4015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850870" evidence="2">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7383" checksum="BD41C76B0FCC805C" modified="2014-03-19" version="1">MNCSFNRRQRSWLAAMVSGMTVITFVPAAVAHASETRLPEETSSSSAPSPSDHAMGLRSKKSMSTKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQQ6</accession>
    <name>W4TQQ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MoxR-like ATPases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70564">
        <property type="protein sequence ID" value="GAE70564"/>
        <property type="gene ID" value="JCM18909_3909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="72"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="3">
        <location>
            <begin position="278"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="378" mass="40910" checksum="9F989CA284E340D6" modified="2014-03-19" version="1">MSAGTTDQTAGEGRPRRGDPNRRSPRIDPLDPREVAQAHRLVEAISRTFDSKVVGQEALRTALLVGLIGGGHVLLESVPGLAKTLAASTLASTVDASFSRVQCTPDLLPSDIIGTQVFNPGSGTFTTELGPVHANVVLLDEINRSSAKTQAAMLEAMQEKQATIGAKTYPMPDPFLVLATQNPIDEEGTYVLPQAQMDRFLLKVIVDYPSPADEVEMLRRLKSGVLASRTVPPVVSRQDVLWLQALSRRVYVDEALLRYIVQIVHATRHGGDYLPQEQAHCLEYGASPRATIAFVEAACAHALIHGRDHVIPDDVRAMRYMVLRHRLILTFELSPPGCPSRRSLTAFSGLSPPPDHGVSHSCPRTPGVIPEASSHGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR02</accession>
    <name>W4TR02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar ABC transporter sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000064">
        <property type="protein sequence ID" value="GAE70674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70674">
        <property type="protein sequence ID" value="GAE70674"/>
        <property type="gene ID" value="JCM18909_4050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="147" mass="15579" checksum="83BD95D380AB010E" modified="2014-03-19" version="1">MKDAPRSTGFAWGLTTVPAMKKEDRHLTSFIESVWIPSGAKNKASTKTFIAWLYSDKATGLFAKAGAAMPTKTGTKGLPAEVAPFYTVYDEPGLKSTIGGFKSAKAVPGIDMKTALLDSVDSVASGKLSVKDWQAKVNEASNKLGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDL0</accession>
    <name>W4TDL0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyruvate dehydrogenase (acetyl-transferring)</fullName>
            <ecNumber evidence="1">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_69</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67035">
        <property type="protein sequence ID" value="GAE67035"/>
        <property type="gene ID" value="JCM18909_69"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02017">
        <property type="entry name" value="TPP_E1_EcPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035807">
        <property type="entry name" value="PDC_E1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041621">
        <property type="entry name" value="PDH_E1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17831">
        <property type="entry name" value="PDH_E1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00759">
        <property type="entry name" value="aceE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="3">
        <location>
            <begin position="150"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PDH_E1_M" evidence="4">
        <location>
            <begin position="496"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="636" mass="71358" checksum="EA82FFEB116DC3FB" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE47</accession>
    <name>W4TE47_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA-specific 2-thiouridylase MnmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67240">
        <property type="protein sequence ID" value="GAE67240"/>
        <property type="gene ID" value="JCM18909_285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="5588" checksum="5C331703853D6541" modified="2014-03-19" version="1">MPATISAVPGGVAVELEDSLRGVAPGQAAVFYDGDLVVGSATICGTDRAGVRAEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE64</accession>
    <name>W4TE64_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67071">
        <property type="protein sequence ID" value="GAE67071"/>
        <property type="gene ID" value="JCM18909_106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="11790" checksum="D6C4B26954D5694E" modified="2014-03-19" version="1">MLSRPAIVYGFPQLLPSFFVLTVLAVVCTWFIPAGSYSKMSYAAGSNQLVIVDPNGATTKHTATQATLDKYGVAMKISEFTSGSITGSVSVPGTYERVASHPAGIGDITNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE68</accession>
    <name>W4TE68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA-i(6)A37 methylthiotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67076">
        <property type="protein sequence ID" value="GAE67076"/>
        <property type="gene ID" value="JCM18909_111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5849" checksum="A15AF5510CBF7BF1" modified="2014-03-19" version="1">MRGKETDRRPGEILSEIRALVDEGVQEITLLGQKRQFLWSSIRRSWRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEN1</accession>
    <name>W4TEN1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67251">
        <property type="protein sequence ID" value="GAE67251"/>
        <property type="gene ID" value="JCM18909_296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11124" checksum="ED44A08F6D5C394A" modified="2014-03-19" version="1">MIDVTSSREGFVARAVNHTVVPVRTTLVGDDDTPVGAMTHSVAGIRLHGRTVALKDRVRHVQAGAGSVLDSVGSRDNATCESKAAAVIQAIQSSRSLFALREDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF88</accession>
    <name>W4TF88_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67421">
        <property type="protein sequence ID" value="GAE67421"/>
        <property type="gene ID" value="JCM18909_480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7709" checksum="F559D6C5551C82BB" modified="2014-03-19" version="1">MIRLGQYLKFANLAETGGQARELIASGMVSVNGEVETRRGRQLHPGDEVRVTNGGQTVTATVDLTEPDIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFB6</accession>
    <name>W4TFB6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67451">
        <property type="protein sequence ID" value="GAE67451"/>
        <property type="gene ID" value="JCM18909_512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9426" checksum="75F78822A2044E82" modified="2014-03-19" version="1">MACGRRGAGTELRHGLGILKFGRNSPDGTGEWAVSVWFTVLFMVVCLVMAVIAMVADRFVSRTYEFVLTAMATVLLLSSRCGNLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG18</accession>
    <name>W4TG18_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA:pyruvate transcarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67905">
        <property type="protein sequence ID" value="GAE67905"/>
        <property type="gene ID" value="JCM18909_999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="193" mass="20951" checksum="FCCFA0A2A11AEAF5" modified="2014-03-19" version="1">MANQPKVMSGCLDINASDKAAEFITFCDSFNIPLVQLVDVPGFLPGVQQEYGGIIRHGAKMLYAYSEATVPKITVVLRKAYGGSYLAMCNRDLGADAVYAWPSAEIAVMGADGAANVIFRRQIKDSEDPAATRAAKIEEYRNAFNTPYVAAARGQVDDVIDPADTRRKITAALETYATKRQSRPAKKHGVMPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG28</accession>
    <name>W4TG28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67388">
        <property type="protein sequence ID" value="GAE67388"/>
        <property type="gene ID" value="JCM18909_444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="13696" checksum="25DA665CFD381999" modified="2014-03-19" version="1">MLHTVKKHDGTLFVTDRSVTGFTDGEEEAAGLTGVVPFLVENSLKQAGARYSKGPDGDSYVVTDNTLVTGQNPASSAATAQRLLDLLAADPRFSARRTVMIIRADRMRKHAGPLSLLAGEHLAVPPQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG39</accession>
    <name>W4TG39_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67756">
        <property type="protein sequence ID" value="GAE67756"/>
        <property type="gene ID" value="JCM18909_837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12043" checksum="7E3C807E91FD5A96" modified="2014-03-19" version="1">MSTAEEKRVAEDQRIAELMGHGSDGRMSAVLTPSPPVPCCCLSWTGDLASSAGVAVLRLTAGEVVFGGVEPHIPQGPQRLGPGHHPVLRDDDRHRAVQAYYREPRNQEIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG42</accession>
    <name>W4TG42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67114">
        <property type="protein sequence ID" value="GAE67114"/>
        <property type="gene ID" value="JCM18909_153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="19648" checksum="729758AE2475D3DB" modified="2014-03-19" version="1">MDTSVNVDTSSRPTHDPATAPGRFVVRDARHEDLPEAAAVQAVCVREIGQGVIPNDVLTEVTGPGIVHTTIEQWNHFMDDGAIFKILVDRLDMRTVGVAMARVSTSSDAPTPWEIATLHVLPEARNCGASDNLLDACIGNRSAYVWVFADNARAFRSTNAMGSTSTRPTVPLTIPSAGWSYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG88</accession>
    <name>W4TG88_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type amino acid transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67423">
        <property type="protein sequence ID" value="GAE67423"/>
        <property type="gene ID" value="JCM18909_482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10609" checksum="A82D566F8BFF85D7" modified="2014-03-19" version="1">MLKSTSLVFAVPFTLDLQYATSAIANCIYAPIPLLVVAAFWYLVMTSVLMIGQHFLEQYFGRGFNGRSSSKRLRRQAAIQTAGTTYKNIALEVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC5</accession>
    <name>W4TGC5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67204">
        <property type="protein sequence ID" value="GAE67204"/>
        <property type="gene ID" value="JCM18909_247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17191" checksum="D9D08F03C269AE58" modified="2014-03-19" version="1">MAVAADADTLGIGDRLSRGFGVFRETESGGGIEFDVLTDQTTRLAGTTIITRKYRCRHNIGVFRFVEFSRNDAIGEPVGDLFPLTTVVFPLDETLQYSSAEFDADQVEVQEINNGHAIEETYTILETGMITATITDVGTGWSITATMGRPTTSTGTGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD4</accession>
    <name>W4TGD4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplM</name>
        <name evidence="5" type="ORF">JCM18909_664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67592">
        <property type="protein sequence ID" value="GAE67592"/>
        <property type="gene ID" value="JCM18909_664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13369" checksum="36A60C688CB35880" modified="2014-03-19" version="1">MTTYSPKAGEVQRNWYVIDAEDIVLGRLATTAANLLRGKHKPQYAPHIDTGDFVVVVNASKIALTGKKATDSLRYDHSGRPGGLRVTSIGEMLAKNPRRAVERAVWGMMPKKTSCRVSSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD7</accession>
    <name>W4TGD7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen III decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68020">
        <property type="protein sequence ID" value="GAE68020"/>
        <property type="gene ID" value="JCM18909_1126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9376" checksum="E3509327FA02DAC3" modified="2014-03-19" version="1">MMTETTTFTADSPLLQAMTGHRPTVTPVWFMRQAGRSLPEYREAREGTTMLESCLNPELAAEITCQLCAATTSTGPFSTPTSWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH0</accession>
    <name>W4TGH0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67627">
        <property type="protein sequence ID" value="GAE67627"/>
        <property type="gene ID" value="JCM18909_700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14019" checksum="EEE55D9F78CCA607" modified="2014-03-19" version="1">MATQPEHIIATGGSWAKDPKKPESIPHVELGYNVTDDDAQRTLAGLLKTPGFSLLKAPKDGKLHAVYHQSTTLPLMFSHLSSLRHGNIRNNSRVSTQRRISLNSMRTTCLLATAACFFRHAEEVNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM6</accession>
    <name>W4TGM6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67573">
        <property type="protein sequence ID" value="GAE67573"/>
        <property type="gene ID" value="JCM18909_644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="12474" checksum="22A664665D4A96CF" modified="2014-03-19" version="1">MSAEALGVLLLSTGIGSWTSVVNPMRVAESRKGNGFNSGSSVGAGCLGALLGMGAGILVAIPMIALVVLVAISGHAWWSILLTFVGGLGWSFLVLHFGIVVGGRRLDRTWDKVLTKITPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGQ1</accession>
    <name>W4TGQ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyribose-specific ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67712">
        <property type="protein sequence ID" value="GAE67712"/>
        <property type="gene ID" value="JCM18909_791"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="271"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="484" mass="52062" checksum="339D06AF0577DE9C" modified="2014-03-19" version="1">MTTNTTVAPPGDNEPLKDGLSLRGVTKRFGTLTANDHIDLDIVPGRIHCLLGENGAGKSTLMNILYGLLPSDEGQVYIDGVEQHFDNSKQAMAAGIGMVHQHFMLVNVFTVAENIALGREESTAGILSMRRARAKVRELSDRYHFDVNPDSVIENLPVGVQQRVEILKSLANDAQYLIFDEPTAVLTPQEIDELMAVMKTLRDEGRAIVFITHKLREVRVIADDITVVRRGRIVGTASADQSEAELAEMMVGRAVKLVVDKDEAKPTGSRLDIKDLTVADDRGSVVVDGVTLSVAGGEILGVAGVQGNGQTELASSLLGLIKPTSGTIRIDGKDTTGAAPVKVIEAGLGFVPEDRQRDGFVGEFSIAENLVLNQVGAYSKHGNLQLKRIADNARDRVEEFDIRTPSASLPVSSLSGGNQQKVVLARELSRSLSVLVASQPLAVSMSVLSNSCTSGWSRSVTTAQRCSSSPLSLTKSRRYRTALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH42</accession>
    <name>W4TH42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosine/purine/uracil/thiamine/allantoin permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67439">
        <property type="protein sequence ID" value="GAE67439"/>
        <property type="gene ID" value="JCM18909_500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="290" mass="30726" checksum="5020EF70A9EC86B4" modified="2014-03-19" version="1">MTQTATTTNTTTRKGIETTGIEIVKESQRTARPQDLFLPWFASNVSVFSMSYGAFMLGFGVSFWQAIAATLVGVIVSFGFCGIIAIAGKRGSAPTMVLSRAAFGTQGNKIPGVISWMTPIGWETSLAITAVLATTTIFRRLGWSSGNSVKICATIIVAFLIVGGAVAGYHIIMKLQAVLTWITGILTVIYLVMAVSHINWHTATSLPAASFPAFVGALTLIMTGTGLGWTNIAADWSRYQSRTSPGFAIAFWNVFGASLPLVILITGGLLLAASSKKIYPTPLGPIPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH76</accession>
    <name>W4TH76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67484">
        <property type="protein sequence ID" value="GAE67484"/>
        <property type="gene ID" value="JCM18909_546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="19818" checksum="6747F49F6E562C2B" modified="2014-03-19" version="1">MADNDQRLHDADRLDIPGPRKVKRPRVQLDSEKFGQFAEATARFMGTAKFLVYMTVIVCTWVVWNLVAIYKLRFDPYPFILLNLFFSTQASYSAPLILLAQNRQEDRDRVSMAEDRRVAAQSRADMEFLAREVASIRMQMGELATRDYLRSELRDELRSLLEEIEASPASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA6</accession>
    <name>W4THA6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68345">
        <property type="protein sequence ID" value="GAE68345"/>
        <property type="gene ID" value="JCM18909_1474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11777" checksum="6DC28C6D5F1C0DA5" modified="2014-03-19" version="1">MNLLMRFYEIDDGTITLDGVDISTVPRAELRSRLGMVLQDTWLFSGTIHDNIAYGCPEASEEDILNAARAAHVDHFVHTLPDGYDTIIDDDGSNVSVGQKTAHHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR3</accession>
    <name>W4THR3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport ATP-binding protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68331">
        <property type="protein sequence ID" value="GAE68331"/>
        <property type="gene ID" value="JCM18909_1460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="14"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="15925" checksum="25324996D4829E6E" modified="2014-03-19" version="1">MGLIPPLTGTVTTTGRVRYLAQNAHVFATSISENVRIGCKEATEDEVLTALSRAGLAIPPRRVVTEDGSSLSGGEAQRLALARVLVNHGTPADPAAHDLLILDEPTEHLDVETSEALMSDLWATTGGAAKVVITHDPLVMARCDRIWHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW8</accession>
    <name>W4THW8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sucrose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68535">
        <property type="protein sequence ID" value="GAE68535"/>
        <property type="gene ID" value="JCM18909_1680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="8769" checksum="53F529560A16B1A8" modified="2014-03-19" version="1">MMFIGQLGWATVGAACGTLLAALAAEVKPEDKVDLLALFTTTGAIAAVSCMILAGTLSDRTRSKLGPRNPWIIGGAIVGTLPSPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX5</accession>
    <name>W4THX5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68028">
        <property type="protein sequence ID" value="GAE68028"/>
        <property type="gene ID" value="JCM18909_1134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7496" checksum="1AF389E6319FB17D" modified="2014-03-19" version="1">MRFLGAEGRARDQAQKNPWPWTYKVSWPTKRSTGKCKLSQESLGAGYYVATVNLGGGPSGRFVMRMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI08</accession>
    <name>W4TI08_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68162">
        <property type="protein sequence ID" value="GAE68162"/>
        <property type="gene ID" value="JCM18909_1281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Succ_DH_flav_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="8122" checksum="152371B9AE9C88E8" modified="2014-03-19" version="1">MCVDALHRRESCGGHFRAESQTEEGEAMRHDDEYQYVAAWEWTGEGHKPTLHKEPLVYKSIQVKQRSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI27</accession>
    <name>W4TI27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68088">
        <property type="protein sequence ID" value="GAE68088"/>
        <property type="gene ID" value="JCM18909_1202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5803" checksum="631C3AE1AF49D11F" modified="2014-03-19" version="1">MVVDNLPRFRWFDDGADHEGKAILIWCVSVLTVRGFFARNHRAGTVLAAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI74</accession>
    <name>W4TI74_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68133">
        <property type="protein sequence ID" value="GAE68133"/>
        <property type="gene ID" value="JCM18909_1250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850763" evidence="1">
        <location>
            <begin position="41"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17974" checksum="4C96AB534FBC7770" modified="2014-03-19" version="1">MGNFTIGRRQLLGGTAALATVLAASACGMSGSGNKPSSQASVNPSAKLEGSIQFQTWSLKNEKFTPYFNKLVKSFEKEHPGTTIKWVDQPGEGYEEKVQQQATAGQLPDVINIPPNFAWQLLKANKVMDLKKADAAAINTYIKGGIDAYTYDGYDGVYGYRGTSAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI96</accession>
    <name>W4TI96_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67874">
        <property type="protein sequence ID" value="GAE67874"/>
        <property type="gene ID" value="JCM18909_966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7900" checksum="4FB7D4085EFB9D76" modified="2014-03-19" version="1">MDITRVGRDKSFGIAKLLEMTGLSKTDVLFYGDRLDEHGNDYPVKAMGIPCVAVDDWQDTLVKLEDLLAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIA5</accession>
    <name>W4TIA5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68163">
        <property type="protein sequence ID" value="GAE68163"/>
        <property type="gene ID" value="JCM18909_1282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="259" mass="27829" checksum="19E5BD9CF3C8D7A8" modified="2014-03-19" version="1">MKINLRIWRQRNSKDQGRLVEYTLDGVSGDMSFLEMLDMLNENLTAQGEEPVAFDSDCREGICGQCGVVINGVPHGGMGVAQPVRTTTCQLHMRSFADGSTITIEPWKSGAFPILRDLIVDRSALDRVIQAGGYVSVNTGAAPDAHAVQVNKKRSDRSFDAATCIGCGACVAACPNGSSMLFTSAKITHLAMLPQGQPERMRRVKAMAAQNDAEGFGGCTNIGECARCARKVFRWSPSASSTATSLRRCSNTTARTTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIA9</accession>
    <name>W4TIA9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanine-D-glutamate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68695">
        <property type="protein sequence ID" value="GAE68695"/>
        <property type="gene ID" value="JCM18909_1846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="14707" checksum="1591198D07297177" modified="2014-03-19" version="1">MALPVDDSKATNPHAANSSMRAFEHIVWIAGGQAKGTHFDNLVTTHAGKLRGVVVLGTDRGIIARSLAEHAPQVPVVVIDDMSREAMARAVREAAKMARPGDTVLMAPGCASLDIWPGYAARGEDFANAARHVDGPDADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB0</accession>
    <name>W4TIB0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease HII</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase HII family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68168">
        <property type="protein sequence ID" value="GAE68168"/>
        <property type="gene ID" value="JCM18909_1287"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6809" checksum="693B0E7AFED58BF7" modified="2014-03-19" version="1">MARDRIMIAMDAEIPGYDFAVHKGYATALHQRRLKELGPSRQHRMSYANVRRAARLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII1</accession>
    <name>W4TII1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphohistidine phosphatase SixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67924">
        <property type="protein sequence ID" value="GAE67924"/>
        <property type="gene ID" value="JCM18909_1024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17972" checksum="F7A8641D301B9F26" modified="2014-03-19" version="1">MHTLFLMRHAQPASHAPGGDRERPLTDVGRRQAREVGTRLGLRNVGHALVSDALRTRQTWDCLQLDCPVEFMRALYYCGTDTVRQRIGEIDDDVDNLLIIAHAPTIPGLTAQLAAMSGAEDEVGCWYPPATLTEVEVDGTWADLKDEYFDKVRLVGVQRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII3</accession>
    <name>W4TII3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1476</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68347">
        <property type="protein sequence ID" value="GAE68347"/>
        <property type="gene ID" value="JCM18909_1476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="232" mass="25253" checksum="724BF7E773E23B46" modified="2014-03-19" version="1">MSADTFINTLGQASHGGDRGKIITLLQQYPHVVIGSGIDFHRLGVIIGWALGLYACAALLMFLQGFLLNTAIQRSMYDLRRQVSAKLDKLPLSYFDGQPHGELMSRMTNDIDNVSQTLLQTLQQLLNALLTIIGVLIMMFWISPLLAVISLVVIPIAGVIAGLIGKRPRDSSPRCGKPPASSTRGWRRRTPAMPSSKPSGAAGLSPRNSTNETRNCVRRPPRPNLSPASSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIW0</accession>
    <name>W4TIW0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68457">
        <property type="protein sequence ID" value="GAE68457"/>
        <property type="gene ID" value="JCM18909_1596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="35311" checksum="8E0EFF6AA53A65AA" modified="2014-03-19" version="1">MNKSDQSYTVTPDTAATLRVDLTDAAAARGDVACASHIGLRHETNQDAAALGIDGSGHHIVLVVADGVSSTEGAEECARVASHTARDYLTATMDQGLPINDDDTVTLFERTFQKAHEAVVSGSGPIGACTLAAAVATHDRIVVGNIGDTRTYWFPDDGDPIRLSIDDSMAQAQMDLGLSREEAERGMGAHAITKWIGASATDVAPRVMAYQPQQSGWLLVCSDGLWNHVPDAGDLARLMADLVSKAHADDHGHASPAGVATDLSPTPIIAAVMTTLRWLCGAGILDPTVGWYSWRLRLASSTPHAKSASMLRRAPRPSNSNSGRVWLSRTPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX9</accession>
    <name>W4TIX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reactivating factor for D-ornithine aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68482">
        <property type="protein sequence ID" value="GAE68482"/>
        <property type="gene ID" value="JCM18909_1623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="284" mass="30416" checksum="EA524F409C012C2B" modified="2014-03-19" version="1">MLRVEPVRAVIHDVFNDHITAAPGMHGLAELTNHEILPTPGAVLLATELFADAVGDAVVVDVGGATTDVHSVTDGSSEWSARVIDPEPRTKRTVEGDLGVFVNARRVAAMTDEGEDEKRLEWLRAIPSDEREAEVTRWLAREAVEAGVGRHAGTVTEIFTPTGKTQVVRGKDLSAVRWVVGTGGALTRVPGGADILRRICTGAGAQLLPSPEATIVIDRDYRFSALGTVAQCYPDEVRRTFVAWIESLTGNTKLPSGEGVGVNDDAATPDVTKKRHPTRLESTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ2</accession>
    <name>W4TIZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68497">
        <property type="protein sequence ID" value="GAE68497"/>
        <property type="gene ID" value="JCM18909_1639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="226" mass="24451" checksum="B0423567A3DF032B" modified="2014-03-19" version="1">MGRSKTEGPGQTSQKNSGHHESTSDKQNLGNLNPNPTDDKKVIERRPRSSANRADSFSASPDKGLFGGSFAALTDALPGNVDEPGKHIEPAQPQQHHPAPELGSPQHHAYEPRPSYQPPDSVSFHHPESLRPEISRPEVEPATKPASRVPAPAPPIKKPQPRLLLSLRKPPQPLPRQKIARGSQFDDNRGGSAAISMTRESATTSLHEVPEYNGSCLSTSSLFAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ17</accession>
    <name>W4TJ17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68786">
        <property type="protein sequence ID" value="GAE68786"/>
        <property type="gene ID" value="JCM18909_1948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009827">
        <property type="entry name" value="MatC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07158">
        <property type="entry name" value="MatC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="MatC_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9368" checksum="6A1DCE767662E403" modified="2014-03-19" version="1">MISLAIGLALAISIAIGRVRKINIGLVAIPFAYIIGAFFMHMKPSAVIDLWPTHIFFVIFAISLFFRICDGQRHARGDRQRVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ20</accession>
    <name>W4TJ20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA (Guanine37-N1)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68159">
        <property type="protein sequence ID" value="GAE68159"/>
        <property type="gene ID" value="JCM18909_1278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="4">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="5373" checksum="550E1998BE64F91A" modified="2014-03-19" version="1">MAWLDVPEVLMSGHHGRIAKWRRDESVRLTCERRPDLTDSDFGVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ51</accession>
    <name>W4TJ51_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68423">
        <property type="protein sequence ID" value="GAE68423"/>
        <property type="gene ID" value="JCM18909_1559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12745" checksum="8E61C3DF6908DACC" modified="2014-03-19" version="1">MKDRPDIFWAQSMLSLLLGSCTHTDMVQTNSIVEIIPPSHHDNNWAASPRNETRIRADPSITDQAARAKSVRVFSALIDSQESLTSWPWALTSLLLEQPSEKKRCTTARLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ67</accession>
    <name>W4TJ67_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68204">
        <property type="protein sequence ID" value="GAE68204"/>
        <property type="gene ID" value="JCM18909_1326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20697" checksum="B7BE170DE7F268B6" modified="2014-03-19" version="1">MLDVLGRHSARMSREWKTTNFVYHDDRDGWKCHEDHWLWPASFDPQKRVVRYRGQHEICGRCPVKDTCSPTMTAREVTMPVDPWPYSEAGLFHRGMTVCVMVAALALPGGMLFVARTVAEVVALIATIAIVCLALVPTAASMRRRPVDIPDAAAGDVSAGYRDGARRRSCPRARRSWAGDDRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB6</accession>
    <name>W4TJB6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68632">
        <property type="protein sequence ID" value="GAE68632"/>
        <property type="gene ID" value="JCM18909_1780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11185" checksum="648DD6529F9BCA40" modified="2014-03-19" version="1">MLVNPDGWNDSLQRCAEAVADEVVVADAWGCCGFAGDRGMLHPELTKSATRREATELAKREFDLYLSANRTCELGMERATGKPWRHALSVLAERMVEYAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR1</accession>
    <name>W4TJR1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68374">
        <property type="protein sequence ID" value="GAE68374"/>
        <property type="gene ID" value="JCM18909_1504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10412" checksum="DE774CEF5D34104D" modified="2014-03-19" version="1">MKPSRVRWDQLPDSVHHRVAEILGSPVSVDHVQTHGATPGVASRVVTADGSHAFIKIGHPASMRPSPASTVVKPPCCRSSPTPRPPRVYLVASTSMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS9</accession>
    <name>W4TJS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein MoaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69041">
        <property type="protein sequence ID" value="GAE69041"/>
        <property type="gene ID" value="JCM18909_2223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="4503" checksum="ABDC5B1953133B56" modified="2014-03-19" version="1">MTSRGDQAALIVNAPGSTGGVRDTLTVIGPMLEHIFRQLAGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT8</accession>
    <name>W4TJT8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68399">
        <property type="protein sequence ID" value="GAE68399"/>
        <property type="gene ID" value="JCM18909_1534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6869" checksum="DD6E376BE0714182" modified="2014-03-19" version="1">MVRGVGGRPSEPDITHDGTGLVLLLLSALVAAGFFGSTCPAGLAMGCEWESRRSSGRCPMLFRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY0</accession>
    <name>W4TJY0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68842">
        <property type="protein sequence ID" value="GAE68842"/>
        <property type="gene ID" value="JCM18909_2007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="380" mass="40618" checksum="3EC026488B293EAD" modified="2014-03-19" version="1">MKGIPAPDGVLVVADSTALRRSLLLLAETLALGLPTAVIVTMTDELRRRGGSLDTTALSQALGVPVVSVVANRGIGIGELRHLIADWQTWDRPPVPPPTATEELAGWVDSVLTSAGYQDPYLDSRTERIDKVLLHPVWGTIVFFVVMFLFFQALFTWAAPAQDAIDNFFSWLGGWVDDNVSNQILAGLLGDGIIGGVGSVLTFVPQILLMYLLLALLDAVGYMSRAAFLMDKVMSRAGLEGRAFVAMLSSFACAIPGVMATRTIPSAKDRIATMLGVPLATCSARLPVYVLLVGMLIPNTTQIGPFSGRGVAMFLLYLLGAVSAMAAAWVVKKRSPTVPASCCPSTWKCRRIASPPCVQWASRCGSPPRPSFIRLAPSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK05</accession>
    <name>W4TK05_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Butyryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69290">
        <property type="protein sequence ID" value="GAE69290"/>
        <property type="gene ID" value="JCM18909_2490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="156"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="310" mass="33503" checksum="ECCFCA6242EC8E30" modified="2014-03-19" version="1">MEEVARVCASSSTVISSNELGTVPLLKYGSEEQRKRYLSDVASGKALFGYALSEADAGSDPAALKCRADEDGDSFVLNGVKAWVTEAGEAKYLVVFAVTEPDDPRHRISALMVHADDPGISYGAPEHKMGIRGSVTREVVFKNTRIPKERVIGRRGHGLSVALGTLDNSRVSIAAQAVGIAQGALDIATDYVQKRKQFGQPLSNFEGIQFMLADMAMRLEAARALTYSAADRSGRQTDDVSYFGAAAKCFASDTAMAVCTDAVQLLGGIGYSKDSAVERMFRDAKVTQIYEGTNQIQRIVIARQLFNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK88</accession>
    <name>W4TK88_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside 5-triphosphatase RdgB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68848">
        <property type="protein sequence ID" value="GAE68848"/>
        <property type="gene ID" value="JCM18909_2013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13394" checksum="A7C1FCD5CD609491" modified="2014-03-19" version="1">MPGIRSARWSGPHANDERNLQLLLDQTFDLPDERRYGRFVCAMAFVDPDGTEITKVATMEGRIIAEARGENGFGYDPMFVPDAQPGDLTSAEMTPEIKDAISHRGQAVRAIVPAVVAHVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF2</accession>
    <name>W4TKF2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69002">
        <property type="protein sequence ID" value="GAE69002"/>
        <property type="gene ID" value="JCM18909_2181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7994" checksum="9979494E199587BE" modified="2014-03-19" version="1">MHYICQTFTMNPDGTPAAPLRMETGFWRPNVDTRKVDVLMLPRRLGRGVDREHRRRQDRAGHRRGGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL9</accession>
    <name>W4TKL9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menB</name>
        <name evidence="4" type="ORF">JCM18909_2710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69490">
        <property type="protein sequence ID" value="GAE69490"/>
        <property type="gene ID" value="JCM18909_2710"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="173"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="330" mass="36607" checksum="45B5B26E6A90AD89" modified="2014-03-19" version="1">MSTLPFVSDIFFDAARWRDVDLPGDPLTDMTFHRLVSRGTSDHTPAGEDLPVVRIAFDRPTIRNAFRPHTVDELYRCIDAARCTPDVAAVILTGNGPSPHDGGYAFCSGGDQRIRGADGYQYESQEASGDEDLATDARRERIEKGRLGRLHILEVQRLMRATPKPIIAAIPGWTTGGGHSLMVVADMAVASREYARFKQVDANVGSFDAGYGSALLARQIGDKRAREIFFLAETYDAEQAEKWGVINRAVDHAELENTAIEWGLTIAGKSPQAIRMLKYAFNMVDDGIAGQQTFAGEATRMAYMTEEAQEGRDAFLEHRSPDWSDYPYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP4</accession>
    <name>W4TKP4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68729">
        <property type="protein sequence ID" value="GAE68729"/>
        <property type="gene ID" value="JCM18909_1883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="433" mass="48598" checksum="90FE6CF2DB7133DE" modified="2014-03-19" version="1">MNTEQILLSLTDLRHNLRQAQFPLDLPEAITQAGLARRIANQLNDYILPRLETIDAPLLAVVGGSTGAGKSTLVNSLVGRMVTQPGVIRPTTTSPVLVHHPDDAFWFDGDRVLPTLVRSRVASNDASSLQLVAEPRIPRGLAILDAPDIDSVVTRNRDLAAQLLQAADLWVFVTSAARYADAVPWDFLNEAQERRASVAVVCDRVPVEAMREVPADLGRLMTERGLADSPLFLLSRRPRRTLKVCSLIRPSPLCGSSCRAWPRISRSDARSSLPRCLERSVQCVRGPLTSLQAWKRRRLRHRDCTRMPSRSWLSPRGRLLPNPLTALCCVARYWHGGTNSSELASSCVLWRRRFPGSETGWCRRSRERRRRSRRSASQWNLAWRVSFLRRPRAGVSGLSPCGTPIRQVVASWRELMRICPARRKGLTRPSLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ1</accession>
    <name>W4TKQ1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69107">
        <property type="protein sequence ID" value="GAE69107"/>
        <property type="gene ID" value="JCM18909_2295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="361" mass="40250" checksum="2CE13BA0EEC41AD4" modified="2014-03-19" version="1">MAKAKFERTKPHCNIGTIGHIDHGKTTLTAAISKVLHDKYPELNEESPFDQIDKAPEERQRGITISIAHIEYQTEKRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPAIVVALNKCDMVDDEELIELVEMEVRELLTSQEFDGDNCPVVRISAFQALQGDEKWTQSILDLMDAVDEYIPQPERDLDKPFLMPIEDVFTITGRGTVVTGRVERGVVKTGEEVEIVGIHEKTQKTTVTGVEMFRKILDEGRAGENVGVLLRGTKKEDVVRGMVLSKPGSTTPHTDFEGQVYVLKKDEGGRHKPFFSHYSPQFYFRTTDVTGTVELPEAPRWSCLVTTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS2</accession>
    <name>W4TKS2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69018">
        <property type="protein sequence ID" value="GAE69018"/>
        <property type="gene ID" value="JCM18909_2199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7483" checksum="52448F7CC5381B62" modified="2014-03-19" version="1">MIPHLMRSFIGHGHRRLVVSSAIAAAIFLVWADTFSRTVFSPAELPIGVITGLLGAPFLLVLVKRETLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT9</accession>
    <name>W4TKT9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68774">
        <property type="protein sequence ID" value="GAE68774"/>
        <property type="gene ID" value="JCM18909_1931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="19671" checksum="C490FE55E65DF5DD" modified="2014-03-19" version="1">MTRQHGFKAGVSVKFPLPDEVEVPVGMPSGPVAILPRGRKVQVTHEEDHMETLLGLLGGEHSVPVVAELGSFIEKLKTTERKVIGVKVGGVMVGLLSAQMSQHFLPVVEACEEAGTTLVCSGRITGNQLKVDMVLEAVKGSELPPEWINDNVYRYAKRLVGQAGAPESSLHQGESSHDDRVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV9</accession>
    <name>W4TKV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-coenzyme A carboxyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68794">
        <property type="protein sequence ID" value="GAE68794"/>
        <property type="gene ID" value="JCM18909_1957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="290" mass="31460" checksum="357D0E6BAC1C6D5B" modified="2014-03-19" version="1">MEIDIHTTAGKIADLGRRIDEAVNAASPSAIEKQHATGKMTARERILRLLDEDSFTELDEFARHRSTNFGMDRKRPYTDGVITGVGAIHGRPVCVFSQDVTIFGGSLGEVYGEKICKIIDFAVKTGCPLIGINEGGGARIQEGVASLARFGDIFRRNTRASGVIPQISIIMGAAAGGHVYSPALTDFIVMVDQTSQMFITGPAVVKQVTGEDVSLEELGGARTHSVKSGNSHYLANDEDDALEFVRDLISYLPQNNLEDPPFYDDGEADLTITDHDRKLDVLIPDSSHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX9</accession>
    <name>W4TKX9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69093">
        <property type="protein sequence ID" value="GAE69093"/>
        <property type="gene ID" value="JCM18909_2277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="25810" checksum="14D81A9FF40536F4" modified="2014-03-19" version="1">MLITAVGTPGSGQTHAFRVRHGMNPHVELWRHGLVVREYLSADRVDDEIVITAHVAPRTSSSQPPRTRKSVPDLSEDRQADEPVRPYQRIAAYAVVRSRRGLLGTECSPRTAVPGLWALPGGGLEPGESPAQAVTREVMEESGQRVRLNRIIDLQSDHWIGRSPTGVLEDFHALRIIYSATSENPTDPTSSTSGAPPSQPSGYRCGVGVGCPGEPRHACVLRPICATSPAPDQPQLPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ4</accession>
    <name>W4TKZ4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69113">
        <property type="protein sequence ID" value="GAE69113"/>
        <property type="gene ID" value="JCM18909_2301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCD" evidence="1">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7937" checksum="EB8BE04DCF11C7C9" modified="2014-03-19" version="1">MLARRSTFAGQLRLASRAGYPCLGTHGTIWVVSATSFQYRWRAVFTCHDRTLPRCPDKKSLGLPLRWAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ8</accession>
    <name>W4TKZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69212">
        <property type="protein sequence ID" value="GAE69212"/>
        <property type="gene ID" value="JCM18909_2406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021414">
        <property type="entry name" value="DUF3054"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11255">
        <property type="entry name" value="DUF3054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="13681" checksum="6C8472FAD5167B79" modified="2014-03-19" version="1">MNDELASPSVRRALVADVVCVILFATMGRASHGEALSPGGLLRTGTPFVLGLVVGWVIVVTARVAALRWLAGVVLWASTLIVGMVVRYFTGQGVAVTFVIVAASFLALTLIGWRAVAVAIRAMRRKEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL53</accession>
    <name>W4TL53_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69262">
        <property type="protein sequence ID" value="GAE69262"/>
        <property type="gene ID" value="JCM18909_2459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8448" checksum="8A843FD92083C4E2" modified="2014-03-19" version="1">MTSLVDDVRGITGRIDLVHANDSQGADGSGRDRHANLGEGQCGADTLVDVIRAAEAPVVVETPGDAESQARDIAWLREHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL57</accession>
    <name>W4TL57_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69466">
        <property type="protein sequence ID" value="GAE69466"/>
        <property type="gene ID" value="JCM18909_2684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="15511" checksum="CBAE240BE16562B4" modified="2014-03-19" version="1">MDVNSRVLEPRGLEKVAKLIDRGVRIPNPLTVDIDEAVDIDNISSDGVVIGPGCRIRGRRTVISAGCILGDEAPMTIQDCQLGTGVKLKGGFAQDAVFLDGASMGSGARPWGHYPRGGGQWGPYRRPQANHPHALCHLGEPHQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL74</accession>
    <name>W4TL74_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69725">
        <property type="protein sequence ID" value="GAE69725"/>
        <property type="gene ID" value="JCM18909_2974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10901" checksum="37D01B3E2D745296" modified="2014-03-19" version="1">MLARDEKIRAEQARRIASARRASKASREAEERQARREEAVALQRRGGSTIDTISDPREMRREIHRALLNYSRHHDLTPQAGWGQLYREVPGPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA1</accession>
    <name>W4TLA1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphocarrier protein of PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69307">
        <property type="protein sequence ID" value="GAE69307"/>
        <property type="gene ID" value="JCM18909_2508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="8408" checksum="E096C8974C9567B0" modified="2014-03-19" version="1">MASKTVKVGSSVGLHARPAAVISQEAAMLSSTVTLATEGGEPIDAKSVLLIMTLGASAGDPVTVAGDNEDDVNTIADLVASNLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL5</accession>
    <name>W4TLL5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69328">
        <property type="protein sequence ID" value="GAE69328"/>
        <property type="gene ID" value="JCM18909_2532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="28786" checksum="03AADD7DB7D242CC" modified="2014-03-19" version="1">MRRTAFIGPGRYQQAIGSLTSWGLVALVVVEAFADFRHGLTSPPWIVSSYLIVDALIILACGPALWLRRHDLGRAGRWMLGGALGFMVWAIVSASFCPLPNLGPEPVARLLLVMAPVTAVATLLAGLSVAAGLTIRSSRRMVIERLWWPAAAMTCASYLQWPRAMKVHGSTRLATGMGGSAVLHVALLLACGVLVAAAMAGCRRVVSGILATGALVAVILTGSRAGLACATLFVLGCAIGSVVWRRSRVVRRAGHRRMVWGGLVALAVASSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN8</accession>
    <name>W4TLN8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible toxin to DivIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69089">
        <property type="protein sequence ID" value="GAE69089"/>
        <property type="gene ID" value="JCM18909_2273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8177" checksum="3555FC2A49AEE79A" modified="2014-03-19" version="1">MTMLEEFTENDRQDVRDQFGREPRGVAGVAWRCGCGKPGVIATEPRLPNGTPFPTTYYLTCPRAASLIGTLESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLQ4</accession>
    <name>W4TLQ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Imidazole glycerol phosphate synthase cyclase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69905">
        <property type="protein sequence ID" value="GAE69905"/>
        <property type="gene ID" value="JCM18909_3171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9256" checksum="EC29E46D25101334" modified="2014-03-19" version="1">MERGAGEILLNSMDADGTTDGFDIEMIEAVRAAVDVPLIASGGAGKVADFVEAARAGVDAVLAASVFHYHTLTIAQVKDGLRHAGFEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR0</accession>
    <name>W4TLR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutaminyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69119">
        <property type="protein sequence ID" value="GAE69119"/>
        <property type="gene ID" value="JCM18909_2307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="6">
        <location>
            <begin position="33"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="228" mass="26097" checksum="BFEFD1D5E162064F" modified="2014-03-19" version="1">MAEPTGDSAESSSDFIHQVVRADIHQDTYGGRVQTRFPPEPNGYLHIGHAKAIVTDFGVAEDFGGTCNLRLDDTNPGTEETEYVESIIADIEWLGYSPAHVVHASDYFEQLYEWAKYLVREGLAYVDDQSPETIREQRGGYGKPGIESPYRNRPAEESLDLLRRMRAGEFPDGSRCLRARIDMQAENMWLRDPVMYRIRHQAHHSTGTEWCIYPTYDWHMVSLTLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV6</accession>
    <name>W4TLV6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt-zinc-cadmium resistance protein CzcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69174">
        <property type="protein sequence ID" value="GAE69174"/>
        <property type="gene ID" value="JCM18909_2365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19684" checksum="BD222856B2AAEA8B" modified="2014-03-19" version="1">MVIAAVGVVVNVAVAWLVARANRRSLNVEGAYQHILTDLFGFIGTLVAGLVIVMTGWTRADAIASLIICGLMLRAAWFLLSQTGRILMEVAPASLDLDEVRHHLMDLDHVRSVHDLHAWTVSSDLPALSAHIVVEDSCFADGHAPILLAQIQQCLSGHFDLDHSTLQLEPPRHAGTENQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM18</accession>
    <name>W4TM18_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69786">
        <property type="protein sequence ID" value="GAE69786"/>
        <property type="gene ID" value="JCM18909_3038"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoeA_C" evidence="2">
        <location>
            <begin position="91"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="165" mass="17208" checksum="68C2805FE8A0CF95" modified="2014-03-19" version="1">MGAYEVVRQGLPELTFHHVVQQPGGPQGAGMVAETPVLALPGNPVGAYVSFHVYVAPLLARLRGLTPNLIDATPAGVTAPIDPLLGRRLVRARAGAPWRSPAAKTQFMPVCWSGENVVPVHSLGSKSHLVTSLPLVEGLAVAGPGVDHVDSGDELSILLTGRSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM78</accession>
    <name>W4TM78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69508">
        <property type="protein sequence ID" value="GAE69508"/>
        <property type="gene ID" value="JCM18909_2733"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23341" checksum="2D31F6EBE617A305" modified="2014-03-19" version="1">MTGEQFAHWIEESTSTVFFFGGAGMSTESGIPDFRSAGGLYTTQHDLPFPAEYMLSHSCLVEHPAEFFDFYRTYLVHPQARPNAGNRALVALEQAGELSTIITQNIDGLHQEAGSRQVIELHGSVHRNRCLDCGRDHPLSVIMDAPGIPRCSCGGMVRPEVVLYEESLQRQDHDDAITAISAADLLIVGGTSLNVYPAAALLRFFPWSTPGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM86</accession>
    <name>W4TM86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70095">
        <property type="protein sequence ID" value="GAE70095"/>
        <property type="gene ID" value="JCM18909_3385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="64"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="360" mass="38452" checksum="755E164327098345" modified="2014-03-19" version="1">MRLAEALDDMVDGRAPVTTDRGEHQPGWDSPGARPLDADMALDHIERAVAADGISMYEHQEEAILEILAGNHVIVTTPTGSGKSLIATAAHFACVAAGGRSYYTAPIKALVSEKFFSLCEIFGAANVGMVTGDASVNADAPIICCTAEILANIALREGHHASIDQVVMDEFHFIGDPDRGWAWQVPLSELPQAQQIIMSATLGDVSDLSVGLTTATGRPTSVITGVVRPVPLEYSWSMKPDHEAIEELVADQKAPVYIVHPSQKQAVERAQSMTSMKLVSTEERHAIAAEIAGFRFAKGFGSTVRKFITAGIGIHHAGMLPKYRRLIETLAQQGKLKVICGTDTLASGSTCQSEPSCSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM93</accession>
    <name>W4TM93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69652">
        <property type="protein sequence ID" value="GAE69652"/>
        <property type="gene ID" value="JCM18909_2897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="7977" checksum="70D3FE0A7E07F8EA" modified="2014-03-19" version="1">MLAQRADTVWPGAADHAGSKSAGRRLPVGVPDPETWRRIKDGEDVPDVEVIAAVSGRRPRSAARRMASTASGRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC4</accession>
    <name>W4TMC4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Osmosensitive K+ channel histidine kinase KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69344">
        <property type="protein sequence ID" value="GAE69344"/>
        <property type="gene ID" value="JCM18909_2550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="KdpD" evidence="5">
        <location>
            <begin position="4"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="4">
        <location>
            <begin position="233"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="422" mass="45769" checksum="3F112465B915ECF4" modified="2014-03-19" version="1">MAVRGRLRVLLGAAPGVGKTYAMLDEGKHLRAGGSDVVIAVVETHGRAATAAMTEGLEVVPRHYVERRGIELPEMDLDEVLARHPDVALVDELAHTNAPGSRNEKRWQDVEELLEAGIDVISTVNIQHIESLNDVVEQITGVPQRETVPDTVLRRASQVEVVDLAPQALRDRLSSGKVYPAERIDAALSNYFRLGNLTALRELALLWVADEVDHALADYRSEHGIDSRWEARERVVVALTGGREGETLLRRGARIAVRAGGGELLAVHVTTEDGLRSPHPGELARQRGLVDKLGGSFHQLVGDDIPETLIEFAKSVNATQLVIGASRRGKLSRLLTGHDVEADIIRASGAIDVHIVSHDAQAKALRLPRMGGALSTRRRIAGFAVLAVFGPLLTWLLVSSRSPEALTTDVLAYELLAVVVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD4</accession>
    <name>W4TMD4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-keto-L-gulonate 6-phosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69697">
        <property type="protein sequence ID" value="GAE69697"/>
        <property type="gene ID" value="JCM18909_2946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04726">
        <property type="entry name" value="KGPDC_HPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041710">
        <property type="entry name" value="HPS/KGPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="23468" checksum="E5A3C620692803B9" modified="2014-03-19" version="1">MTTMPRLQIALDTYDLPSALAPLATAVDQIDIIECGTILVLAEGMDAVRAIRAAYPDKTILADVRIAEAGAKIARMCFEAGADLVSCVAGASLTTIDQVCKVAGEFGGEVQVELADEWYDADRAHTWRTLGVQHVIVKRSRDREVAGDLSWKPEDLGRVDELAGMGFTVTVTGGITPEDLPVFAGHPVGIVIAGRSIVAADDPKAAAKRLRSTLDEVWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF8</accession>
    <name>W4TMF8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2971</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69722">
        <property type="protein sequence ID" value="GAE69722"/>
        <property type="gene ID" value="JCM18909_2971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="8">
        <location>
            <begin position="53"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="190"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="449" mass="47757" checksum="1C861554D6C772F5" modified="2014-03-19" version="1">MVSEIGGFLAVSLRHGWHLVVGSTVVGRDGMGTSLASGRCHSAMGSPGDDSAVITWMAGTVSTTGLVANLAAAPFVPPASALGMVTGLLAFIWPPLGTPFGRLAGWCVQPIIWIAHFGAKAPSGLIRWPAGGWALGVLAGLCMGLALITPTVLARPWLTALAGLAVIAAIVVRPPLPGWPGQWQVAICDVGQGSAALVRAGPHEAVVVDTGPDSHRLSRCLDDLDVAQVPMVILSHFHADHVDGLNAVHDHGLTRAIVVSQLSSPPWSAKRVAQTAAQLGARVVVANPGRVMTAGTAKLELWGGTQLSDTGKDESGEEPAVENNSSVVIKATVDELRVVLPGDAEPEEQHHILTGGTDLSSDVLVLPHHGSARQDEASGRRPGQVWRWHLLAREIPSDIPRTRHYLWLSRWGCSCIALILRGRCYWPAMVGPYWSKHGRDVLRRRERRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI9</accession>
    <name>W4TMI9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70205">
        <property type="protein sequence ID" value="GAE70205"/>
        <property type="gene ID" value="JCM18909_3503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15363" checksum="6C7A31FF1C17486E" modified="2014-03-19" version="1">MKVTRRHRATRGRPHTVFTLVSDEGPRAYRLLAQMLVDEVALSNNPTAMAMRIGQRWGRHRRGDLIAVLDDMGFSPAAEEGGIVLRHCPFLDLARDHPQVVCSLHCGVVEGVTGQAATIDANPGVRCVVHTCVTDALERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM0</accession>
    <name>W4TMM0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69951">
        <property type="protein sequence ID" value="GAE69951"/>
        <property type="gene ID" value="JCM18909_3224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5285" checksum="162E1DFC0952F1B6" modified="2014-03-19" version="1">MIGSARYADGAFEWYRAIDSPRPNDRLEAGRSGHAGAPPTGRGGRLGLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMP9</accession>
    <name>W4TMP9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-xylulose 5-phosphate 3-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69698">
        <property type="protein sequence ID" value="GAE69698"/>
        <property type="gene ID" value="JCM18909_2947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10323" checksum="7804C43C8D807C76" modified="2014-03-19" version="1">MTESLTDGVTLGIYEKALVGNPLATDDDWRRFLDQVPEAGFSFVDLSVDESEERMARLGWDQRRRRMVRHCAEVAETAIGGVCLSVHRRIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS1</accession>
    <name>W4TMS1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_2967</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69718">
        <property type="protein sequence ID" value="GAE69718"/>
        <property type="gene ID" value="JCM18909_2967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="10">
        <location>
            <begin position="47"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="11">
        <location>
            <begin position="228"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="426"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE69718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="650" mass="73196" checksum="A2D8AED21DFB09C0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU3</accession>
    <name>W4TMU3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formiminoglutamic iminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70036">
        <property type="protein sequence ID" value="GAE70036"/>
        <property type="gene ID" value="JCM18909_3317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43608">
        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="400" mass="42956" checksum="549889792DE1689F" modified="2014-03-19" version="1">MPGFANTHSHVFHRGLRGAGEGEDFWSWRTEMYRLANRLDPDSYYRLARAAFAEMVAAGYTSVGEFHYVHHQPDGTPYRDHAMELALVNAAIEAGIRITVLDTCYLHAGPRAPLGADQTRFGDGSVEGWLERWHALRDALPDSPLVTMGAALHSVRAVSPDEMATAVSGLPKRVPIHIHVSEQPRENTECLAAHGLTPTAVLDRAGVLSDRTTIVHATHLTDDDIAMIAASDTVVSLCPTTEADLGDGIARVKDLQDAGVRMAIGTDEDVITDPFTELRMLESTARLATGTRGIIDCEALWKIGTRNGVESLRPAAEPLPRQTSTPGPGSAGLAAGDPADIVVVEPSSARLAGVDPTRWPLVATANDVAATIVAGEWNRLDAAVAEDLRHVLDELRGRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW0</accession>
    <name>W4TMW0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RfbX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69524">
        <property type="protein sequence ID" value="GAE69524"/>
        <property type="gene ID" value="JCM18909_2749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="325" mass="35700" checksum="1262213C9D957B49" modified="2014-03-19" version="1">MTNTTTEPTPARSGATPEPGEKRVRFPRTRAYIQRHEFLASVTKVISGTGLAQLIAALATLYVTHHIDPADWGIYGAIMAVSQFVIPAAALRYDMAIVLPRDDSEAKRVFRLATRINAIVSGVAMAAMVPLGPYLSGLLGKPQARWWLLAVGPITFTYAQVNVVNFWANRRKRFGVIGTNAVWCQSTTAAGRIGSCAVCLGAFGQVIATFLGKCLALNNFRRQLGSDLRGIKEAEVPLRTLMRKYRQLPLLTAPNVIVDAIRQQGVNMIIMVRFSTSGYGRFSIAWTLMQMPASVINQALSQVFFQKLSVSDAGRFYQTVKKSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ5</accession>
    <name>W4TMZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69902">
        <property type="protein sequence ID" value="GAE69902"/>
        <property type="gene ID" value="JCM18909_3168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10708" checksum="AA0A627E12F2CC1A" modified="2014-03-19" version="1">MHSHGEETPEEEISPQQVNQRIGALAPQDTVLGMVRQRRTSSSIVGSLTWICTPTPYQTSSSLPKHGGALLFGSQTGHGRRPDAYCRCRRLAIPVRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN40</accession>
    <name>W4TN40_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69932">
        <property type="protein sequence ID" value="GAE69932"/>
        <property type="gene ID" value="JCM18909_3201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="22945" checksum="152BDB118CF353C3" modified="2014-03-19" version="1">MNKADVLLNGVETSTGPQPGALALLEQAVHELDGTGDADPRAAELAERARQMSYDLTDLAASVAGHAARAKADPQRLEELGGRLAAIQRLLRARTTTLDDLLESTAEDRHRLTELDPGATDLDSLGQQVEQLRSELRRSADHMSAVRRRTAVRLAAEVRPELAALVMPHARLEFRVEPAPMGPRGADSVTIMLAANPGSDLAPLAKAASAESFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN52</accession>
    <name>W4TN52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70156">
        <property type="protein sequence ID" value="GAE70156"/>
        <property type="gene ID" value="JCM18909_3452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849157" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10577" checksum="9AA35DA4433FED0B" modified="2014-03-19" version="1">MVLDVVVAAAGVTLLVWGIMVMASPTISCRGVEMHPGDTCHKATYTATHTDTVQTYEQRRRSIAQSRPTVIGLGIALTVFWCGDDLADREGPRSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND1</accession>
    <name>W4TND1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70460">
        <property type="protein sequence ID" value="GAE70460"/>
        <property type="gene ID" value="JCM18909_3787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="4940" checksum="0334B88BF8A453D4" modified="2014-03-19" version="1">MGRAPHKRSWQSLGAGDIELCYATMKVMEVDNLAGSSFFEDFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNE6</accession>
    <name>W4TNE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70480">
        <property type="protein sequence ID" value="GAE70480"/>
        <property type="gene ID" value="JCM18909_3807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8209" checksum="E8813F91B3BBD1CC" modified="2014-03-19" version="1">MGAWRPGTVRGHQPPPDDNGCDDVAEHDHIPTVVPTPSTSCAPSTSELSWWASRSSRRSIFRDTPSRWWPPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM4</accession>
    <name>W4TNM4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69993">
        <property type="protein sequence ID" value="GAE69993"/>
        <property type="gene ID" value="JCM18909_3269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="H_kinase_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9165" checksum="E2FA4E7679DD20F3" modified="2014-03-19" version="1">MPALNRIVADRTRLDDADITWLEDLVDDWQMLADTSFSDSSCGFPIDPNVFWAVARCVQILARLLWKMTSSVSLSLMTTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR0</accession>
    <name>W4TNR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoamide acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70600">
        <property type="protein sequence ID" value="GAE70600"/>
        <property type="gene ID" value="JCM18909_3950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="231" mass="24644" checksum="3793804C087ABFF3" modified="2014-03-19" version="1">MSRLRKVIASRMVESLQISAQLTATVEVDMTAISRIRNAEKAAFKAREGVGLSYLPFITKTVVEALKANPTFNANIDTEAGTITYGSSENIGIAVDTPRGLLVPVIKNAGDLNIAGLAHQIGDLAARTRNNKVTPDELSGGTFTITNYGSAGALFDTPIVNQPEVAILGTGALVKRPVVVTNEFGEDTIAVRDMMYLSLSYDHRLIDGAVAARFLSGIKARLEEGDFAGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW3</accession>
    <name>W4TNW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69894">
        <property type="protein sequence ID" value="GAE69894"/>
        <property type="gene ID" value="JCM18909_3160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="PTHR42825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="216" mass="23272" checksum="BBEDBB37DDA01888" modified="2014-03-19" version="1">MIAYQDFLGLAAASTVLFSVIGSPVGAYFVSGVKPLRLLVERRQARTAPGGTGEAKCGGNYAASLRSQIDAKTRGCNEVLFVDAVEHRWTEELGGMNFMAISKDGQLVTPELAGTILRGVTRKSILEVAPDLGLEPVERKIDVDELLDGVRSGEFPEVFACGTAAVVTPIGSFLDGDTDVKVSEPTGKTTMEIRRRLLDIQFGRAEDTHGWLKRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY3</accession>
    <name>W4TNY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70411">
        <property type="protein sequence ID" value="GAE70411"/>
        <property type="gene ID" value="JCM18909_3729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10678" checksum="B8BA5B58FC649F8F" modified="2014-03-19" version="1">MTGLEYEDRTSGDVKTIELAGVFVQIGLLPNTEWLEGALERNQRGEIVIDERGTTSAPGVFAAGDCTAQPYKQIIISMGAGATAALGAFDHLIRQNPTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY9</accession>
    <name>W4TNY9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70128">
        <property type="protein sequence ID" value="GAE70128"/>
        <property type="gene ID" value="JCM18909_3424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="252" mass="27546" checksum="59A3283A02668A15" modified="2014-03-19" version="1">MRVKQASVVLLGVVLASVMVFLGLWQMNVFESQRDDSTQARINEPVITWNEAPKKADVMAQYGRRVTVTGTFQPSTTTLIGTSWPVRVVTGIKLTSGETMAVVRGKLSKGERVPAAPTGTITVTGVLAASEANDGRRDSQMPAAVLPSLRLEVLTQTWPQPLVPATLTLDEKKMHTLRGSPQRKRYSRRVTVANVIAATHCNGGFLRSLLLPCLSPSPEQQANIRNDGLLDAASVDVLQYSVSRETQRRRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP08</accession>
    <name>W4TP08_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69919">
        <property type="protein sequence ID" value="GAE69919"/>
        <property type="gene ID" value="JCM18909_3186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4341" checksum="78434640A001C8E0" modified="2014-03-19" version="1">MMPGSDGYDSQGGAPQAGIMKGDSLIFCRRHRCHTFAQGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP36</accession>
    <name>W4TP36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exodeoxyribonuclease VII large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70297">
        <property type="protein sequence ID" value="GAE70297"/>
        <property type="gene ID" value="JCM18909_3605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuc_VII_L" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="1">
        <location>
            <begin position="180"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="277" mass="30005" checksum="0DEAB3A3235CEFE4" modified="2014-03-19" version="1">MPRGIGLITGAGSDAERDVQRHATLRWPAARFVVHNTRVQGPMAAQQIIAALADLDADPTVDVIVIARGGGALEDLLPFSDEALVRAVYATRTPVVSAIGHDRDNPILDLVADLRASTPTDAGKLIVPDAADQSQAIETARTRLRQAVTRFIDVESGHLTQIRSRPVMVNPAATLDIAVERLDSTLQRLRLATHRVLDAESRDVNHMLERVRAMSPKATLDRGYAILADAEGDSITSVNDTNARANLLVYLSDGTLSVTVDSLDRRTPNRPTFQEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPI4</accession>
    <name>W4TPI4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysozyme M1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70646">
        <property type="protein sequence ID" value="GAE70646"/>
        <property type="gene ID" value="JCM18909_4013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7581" checksum="CA4B642DEFE1C732" modified="2014-03-19" version="1">MGSAASDITAVAPLWIARYSSTVGELPSGWDAWTMWQYSDTGYDHDRMAGTREDLEKFATNETATPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPW6</accession>
    <name>W4TPW6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70418">
        <property type="protein sequence ID" value="GAE70418"/>
        <property type="gene ID" value="JCM18909_3736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10713" checksum="4C169DF4D04648E9" modified="2014-03-19" version="1">MWTCDFRPSERIHIAAKHGEGNYVADAATVAALEANNRVVFRYTANPNGSVHDIAGITNEAGNVVGLMPHPEHSVEELTGAGTDGLGFFRSLMTFLSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ02</accession>
    <name>W4TQ02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription termination protein NusA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70612">
        <property type="protein sequence ID" value="GAE70612"/>
        <property type="gene ID" value="JCM18909_3966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH_5" evidence="6">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9156" checksum="BC9EF7DC06CC9BF4" modified="2014-03-19" version="1">MHELDEEKIDIIDWSEDPAEFVGAALSPSKVSSVTVIDPKAKTARAIVPDYQLSLAIGREGQNARLAARLTGWRIDIRPDNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ19</accession>
    <name>W4TQ19_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70632">
        <property type="protein sequence ID" value="GAE70632"/>
        <property type="gene ID" value="JCM18909_3990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11513" checksum="53B4932BCB86EB5E" modified="2014-03-19" version="1">MKYTAHVNMVTKPYIGLPTTRTPYTLVDADWATTWMIDETYEAHYHGTSVEISIYGEGPNCSVLTNRIYTDQPTDVTTALADYGFTIDTTNTSKTILTLTNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ36</accession>
    <name>W4TQ36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-damage-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3658</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70344">
        <property type="protein sequence ID" value="GAE70344"/>
        <property type="gene ID" value="JCM18909_3658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044644">
        <property type="entry name" value="DinF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42893">
        <property type="entry name" value="PTHR42893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="204" mass="21536" checksum="7DE8FDFAA4954402" modified="2014-03-19" version="1">MLVAIPATVAGWFGASGAVAEQAGRYLRITGFGVPAMLATMAITGVLRGFQDTRTPLIVTIITFSANLVLNLWFVLGMGWGIQGSAMGTLVCQIAMAVALVWVLRIRTRGLDLSLVPHLSGIASSLRDGIPLLIRTLALRAALYVTTWVAARSGAITMASYQVTMTMWNLLLMTMDALGIAGQALTGASLGAGDVRRTRSLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQD4</accession>
    <name>W4TQD4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease protein DppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70434">
        <property type="protein sequence ID" value="GAE70434"/>
        <property type="gene ID" value="JCM18909_3752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850869" evidence="5">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="66"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="236" mass="24452" checksum="51864A8C3A7CFA13" modified="2014-03-19" version="1">MKRAGLVIGCVLVGIVVIAGATSAVWTPHDPNLVVPAERLMGPNGQHWLGTDGFGSDIASRMFVGARTCLLVGVVSVLIAAGIGVPWGVTSAMLPRPWSTVVGRAADLLYAFPALLLAIILAAAVGGSTLTGMIAIGVSTVPVFARITRTASRQILAQDYVVAARSSGMAWRSVAFNHVLPNIAPLIGVQASVSYGTAILAEAALSYLGLATPATVPTWGRMLRDSQVYLFLIHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQE5</accession>
    <name>W4TQE5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70628">
        <property type="protein sequence ID" value="GAE70628"/>
        <property type="gene ID" value="JCM18909_3986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5703" checksum="E897671912518287" modified="2014-03-19" version="1">MGKHPQRHAESAFKMPAGRVMSWVGILFFITILIMLGFSADSRQALSPLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQK2</accession>
    <name>W4TQK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000066">
        <property type="protein sequence ID" value="GAE70688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70688">
        <property type="protein sequence ID" value="GAE70688"/>
        <property type="gene ID" value="JCM18909_4065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14055" checksum="A79A04207561432A" modified="2014-03-19" version="1">MTGDRPAPINLENLRTLSRPASATILKAGPELDGETLDDSSVGEDAKESWWSSRTHRIVVGAAGILIIVAVVLWIVVGGGFRGANKQGSKVVDGLSASLPMQTYPSGLSVTRAATVNKGTLKYSLTYRTISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDR2</accession>
    <name>W4TDR2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67095">
        <property type="protein sequence ID" value="GAE67095"/>
        <property type="gene ID" value="JCM18909_131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5772" checksum="7DB2D8B4CABCC7B5" modified="2014-03-19" version="1">MTGVSYRRSAELAAIVGPYGGYAENAEPHQPSWLSIVMPTVRFTLCITMTPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDW3</accession>
    <name>W4TDW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-deoxy-D-xylulose 5-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67150">
        <property type="protein sequence ID" value="GAE67150"/>
        <property type="gene ID" value="JCM18909_191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5495" checksum="0F5EA0FF6FF5E514" modified="2014-03-19" version="1">MALLDDIGCPDDVRKLTTKQAEDLAEEIRAFLIDKVSRTGGHLGPNLASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEF8</accession>
    <name>W4TEF8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67171">
        <property type="protein sequence ID" value="GAE67171"/>
        <property type="gene ID" value="JCM18909_213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9310" checksum="7C88CFA4746190D6" modified="2014-03-19" version="1">MRPAGAGQAVPYPRLTAAAHLARRDVPVRRAGLDSAQTKEAARLYQAGWTLVQLGRRFEVDAQTVRRTIARQGRVDPTGWTTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEQ2</accession>
    <name>W4TEQ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial extracellular solute-binding protein family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67425">
        <property type="protein sequence ID" value="GAE67425"/>
        <property type="gene ID" value="JCM18909_485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="27"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="252" mass="26659" checksum="5E904344D60AB21A" modified="2014-03-19" version="1">MPRSSNRLRKTSPSPRWFPTTSKKSGTLRNGVATNYAPTEFIDTDGSTVIGYITAVSKLMGLKVATTNAAFPSLIPALGSKYDVSVSAFTITLEREKQVTMASYFKAGFSMAVPKGNPKKISPDDLCGHTVAIQTGTAQETAAQHKSKQCVKAGHKPIDLLSYASQSDATTNVTGGKADVLYADSVITATPSSRHPNSWPLAASPPKNDGGLSKAIQVATQKLIDDGTMKKLLAAWGTQDGLIKTSQVNPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEY1</accession>
    <name>W4TEY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66973">
        <property type="protein sequence ID" value="GAE66973"/>
        <property type="gene ID" value="JCM18909_1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850694" evidence="1">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE66973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7679" checksum="AE25C561A58D9A96" modified="2014-03-19" version="1">MPMKKIITGIVAALAISSFSVAVPAQATTDSAPTQNAVNTQPKAHVKGIIDGLCSIYPDWCYNWADSVPMSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF08</accession>
    <name>W4TF08_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67545">
        <property type="protein sequence ID" value="GAE67545"/>
        <property type="gene ID" value="JCM18909_612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16832" checksum="0E24D8B4A81F7530" modified="2014-03-19" version="1">MRSCYRPASSRIDRPHDGGVLADRPDPRRTILTGASFGGLTALFAFAEAPELCSSVSAQSVSLWRYQTGAFTEFLAAAASRVGVHNARVRLHAGRYEGDMASDAAILTRALHDVANWTVLLVIHEGGHDWAWWQQAMLDDVTGFLNGKAYGDLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF27</accession>
    <name>W4TF27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_53</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67023">
        <property type="protein sequence ID" value="GAE67023"/>
        <property type="gene ID" value="JCM18909_53"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11722" checksum="797D590C446BD8DF" modified="2014-03-19" version="1">METTQLASGTLFIHSASTALRSHIEWAADAAFVMPALLRWTSQPVEPGTWRAESAWRGDVVDARTFISTLAAWQQVRVELTVETGAAPHRWSVTPDLGIFFRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF38</accession>
    <name>W4TF38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-specific component CbrT of predicted cobalamin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67575">
        <property type="protein sequence ID" value="GAE67575"/>
        <property type="gene ID" value="JCM18909_646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9578" checksum="B18A470EFD40247F" modified="2014-03-19" version="1">MDFAFWPFNLGTSTQLSFDPHASPLTNLWHFVLFNMATSMGWNLGRALTNVVCLALLGGPILRVLRRASRRAQFVPDAISLGTEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF70</accession>
    <name>W4TF70_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67615">
        <property type="protein sequence ID" value="GAE67615"/>
        <property type="gene ID" value="JCM18909_688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="15743" checksum="B228FAAE2A4951A2" modified="2014-03-19" version="1">MIHAATMPAGKTAVFFPRIDATMSGLMAVRTVVTTAVIGIVATTAGGPMTASSAPTNRVDRATTPIVIGSVTTVADRRGIVTIGVRTVVGSVATAMTAGIAIMAAVTSTAGTPETGVRTVTAGAMIAVMTAGQTARITAATTGPVATTTTTIWIGRPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFG6</accession>
    <name>W4TFG6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67710">
        <property type="protein sequence ID" value="GAE67710"/>
        <property type="gene ID" value="JCM18909_789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850698" evidence="2">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="8172" checksum="C08D849184D1B8D8" modified="2014-03-19" version="1">MKKLHLAIPAVFAAVALSLSACAQAPDASTGSSAGSSTSAAGKDSSNSGEFKACMVSDSAGFNDKSFNETSLQGLNKAASDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFM5</accession>
    <name>W4TFM5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67332">
        <property type="protein sequence ID" value="GAE67332"/>
        <property type="gene ID" value="JCM18909_379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6822" checksum="84E2EA7CC5E54539" modified="2014-03-19" version="1">MKLSFFLGNEIPYDQLSGEIAASKPRRVAMAQASLGYFIGHNDLFSTWGKEPLGTQTVMYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG19</accession>
    <name>W4TG19_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_434</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67378">
        <property type="protein sequence ID" value="GAE67378"/>
        <property type="gene ID" value="JCM18909_434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="428" mass="45993" checksum="AF0DFFE995A3C389" modified="2014-03-19" version="1">MVAMADKSVPTSDHIRDIISFVEASPTSYHAVAELTRRLEQAGFQRLEETESWPSVEGRRYVVRDGAVIAWITPEKVTPQLGARIVGSHTDSPSFKLKPNATVTNQGWQQVGMEVYGGGLLNSWLDRDLGLSGRLVTRDGQAHLVRTGPILRISQLAPHLDRTVNDDLKLDRQRHLMPILSVGKPDLDVEDLLCEAAGIKRDELAFHDIFAHLTQSPAVIGSYGEFLASQRMDNLSSVHSSVAAFVDVKPTSDVAVMACFDHEEVGSATRSGACGPFLEDVLARIAEGFGMTGAAYRAMIARSSCVSSDAGHGVHPNYVEKFDPANHPLLNEGPLLKINAHQRYATDGVGGALWQRACAAAGVPTQNFVSNNSVPCGSTIGPLTATRLGMLTVDVGVPLMSMHSTRELAGTADLTYLSKALGAYWAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG62</accession>
    <name>W4TG62_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase I</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67935">
        <property type="protein sequence ID" value="GAE67935"/>
        <property type="gene ID" value="JCM18909_1036"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="6">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8972" checksum="3A9C5202C79F34E2" modified="2014-03-19" version="1">MLATTFDISHDEMVLVRDIELQSMCEHHLLPFIGVAHVGYIPARDGRVTGLSKIARLVEVYARRPQVQERLTTQVADAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG96</accession>
    <name>W4TG96_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxygen sensor histidine kinase NreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nitrogen regulation protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JCM18909_216</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67174">
        <property type="protein sequence ID" value="GAE67174"/>
        <property type="gene ID" value="JCM18909_216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="289"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE67174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="497" mass="52706" checksum="58DF048E19392193" modified="2014-03-19" version="1">MSDEPMSPRIGVKLMLTGWLLLAPPSTDLGIGVRLGPSTLARGVCRPCGLCDVRIRVTGASALHLRQDLHSGPMNTTTCARDGLHRWRGMDAGHRGRAVAIEVGMQIGIQVLFAGLVIFTLVMALVLSPPRLGRILGWAALLIVVYTALMGTHVMSRSRREMWRPLLVAAMVVVSILLAIDFPYAAYLTIPLSFVYLDHLPPLQACVAVVVGAVAILLGVGLTGGWSGGGKKIVGPVAGAAVAVVVGLSLKAMQAQASELERLNVDLLAVQKRLAESQRQAGVLEERARLAREIHDTVAQSLSSIGLLLSAVERTAPDHPAIEQIRLAHLASSDALSETRGLIAELAPPTVVHQGLSAVLERLGATTWSIGGLHVDVDCPDTSDLPMEIQTALLRLCQAAMSNVVRHAHAHHASIRIVRPNPGHVLLRVSDDGVGMDLDASVRDGAFGLQAIRQRVEAASGEVSLTSKPGEGTRVEVDLPCRAASPHIDRHSQGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA6</accession>
    <name>W4TGA6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67184">
        <property type="protein sequence ID" value="GAE67184"/>
        <property type="gene ID" value="JCM18909_227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="15177" checksum="489922509D470DA3" modified="2014-03-19" version="1">MIPMAGPGVRIVLDDANAAPADELGDKDMRKLVNAVWQSGAEAVAINGHRIGPRTAIRSAGSAITVDYVSLSRPYVVEAIGSPQKLPAELADTPGGRWMTYLRDNSSITYQVTTKDRVSVPGSKASVSHASLIVDNETMNGNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF4</accession>
    <name>W4TGF4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67612">
        <property type="protein sequence ID" value="GAE67612"/>
        <property type="gene ID" value="JCM18909_685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20638" checksum="D438B2CD4A4CB1EE" modified="2014-03-19" version="1">MWVWNLAALMLRSRKSWLRMVPMAVALLIMTVSLGVNRSINLSPEQSVTSTLGAADGLVSPGFSVLAGSSSPTVPINRWKVRQINPYLETQVSVKGLPEEVLYQESSMPGINTKGRYALISGKWPTKPSEIVVTPSLRQGIGGKNKLVLEPGNYDLTIVGTVGATFDKSSREILARSGTWQAWPLTQKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI7</accession>
    <name>W4TGI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_593</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67528">
        <property type="protein sequence ID" value="GAE67528"/>
        <property type="gene ID" value="JCM18909_593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="11">
        <location>
            <begin position="21"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="287" mass="29828" checksum="75700058DBDE52DA" modified="2014-03-19" version="1">MEELLWRKTLLPPAPRKKRQIPGFSQMQRIGRSLMLPIASLPVAALLMRFGSADVLGADGLAKHASWMQPVADVLAGAGGAIFDNLPLIFALGVAVGYAKKADGSTALAALVGYLTFTGAGTSDKTQGGVLHALAPYFSQKTGVINYGVLGGIVIGLIAAKMYEKYRRTKLPTYLASLAAAASCQLSPPPLPSSQASSWLSFTRPSTGCSISRSAVSSWPTGPTQERDSYSAPSTVSSSPSACTTCSIRCRGSSSAIAPMPPARLCTVTSPASLVVRPARMLGPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK6</accession>
    <name>W4TGK6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67667">
        <property type="protein sequence ID" value="GAE67667"/>
        <property type="gene ID" value="JCM18909_742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6234" checksum="6ED01F5C9CC8D387" modified="2014-03-19" version="1">MIASTMMIAAMMSRCGVLRVFSGSASGMEAEDIGVLMVGLLEMSQRGVANGHRSWDRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY5</accession>
    <name>W4TGY5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair protein RadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68031">
        <property type="protein sequence ID" value="GAE68031"/>
        <property type="gene ID" value="JCM18909_1137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="4">
        <location>
            <begin position="96"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="260" mass="27514" checksum="C73B2F4EB7870ADA" modified="2014-03-19" version="1">MAALPAGGLTETQRGTPSSSNLSVPAGRVNAMARKTQTPTWVCTECGWTTTKWVGRCGECQTWGSVVEKGVPKLTEVTSSTPTSKAVPIGQVNEQAANRHLTGISELDRVLGGGLVPGVVVLLAGEPGVGKSTLLLDVAAKWAKAGRRTLYVTGEESAAQVRLRAGRTKSLADELYLASETDLGTVLGHIEQTEPSLMVLDSVQTVGTSQADGSPGGVSQVREVTGAWYGWRRDAGCSHHRRPCHQRGVDRWPAHHGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH38</accession>
    <name>W4TH38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68285">
        <property type="protein sequence ID" value="GAE68285"/>
        <property type="gene ID" value="JCM18909_1409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="9839" checksum="4FE8522C71E895F8" modified="2014-03-19" version="1">MIAVPLVVAALLLVLGRRSDAWGHVLATVVPIVSFVIGLVLFLSTCSDVTVRLVLSTWGSTDLSTSGRGICEWGCLLTSSRSCLCCSSPSWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA1</accession>
    <name>W4THA1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="6">4.1.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Fructose-1,6-bisphosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67897">
        <property type="protein sequence ID" value="GAE67897"/>
        <property type="gene ID" value="JCM18909_990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16236" checksum="C5EDE9B39E9F4EE7" modified="2014-03-19" version="1">MLGLGEKGRYTTALTFGNVHGAYKPGYVKLRPGILKEIQDECGKKYGKEKPFDLVFHGGSGSTAQEIADAVSYGVIKMNIDTDTQYAFSRPVVEHMFKNYDGMLKIDGEVGNKKMYDPRSWGKKAEAGMAARIVEACEQLGSKGTSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD7</accession>
    <name>W4THD7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68375">
        <property type="protein sequence ID" value="GAE68375"/>
        <property type="gene ID" value="JCM18909_1505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="11662" checksum="83CE9390BA046662" modified="2014-03-19" version="1">MVADMFDEHIDYLVIINTTCTRHNSNENLRCRRERPKLPAMGRICTSPVFRGSWVDRVIFVESDRVAVEMAKLRPYLVLINAKSPWVYRWGRSSSGWWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG9</accession>
    <name>W4THG9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Holo-[acyl-carrier protein] synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67604">
        <property type="protein sequence ID" value="GAE67604"/>
        <property type="gene ID" value="JCM18909_677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5746" checksum="BDAC42094646F4B3" modified="2014-03-19" version="1">MVRKVLTHTEAVMPARSQAARFAAKEALYKALVEEKDFPGKTARWSLTVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN9</accession>
    <name>W4THN9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68027">
        <property type="protein sequence ID" value="GAE68027"/>
        <property type="gene ID" value="JCM18909_1133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9307" checksum="EECCC304B201C026" modified="2014-03-19" version="1">MRSDPDVTVRVCFTFWVSQWQLVELLTSTVKVSVSPTWGFFWYLRSPSPTAANPHTSLTAAESMPRPTAMGIPSGAQTYLGSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ5</accession>
    <name>W4THQ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67948">
        <property type="protein sequence ID" value="GAE67948"/>
        <property type="gene ID" value="JCM18909_1050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7899" checksum="52BBDFB411180D6D" modified="2014-03-19" version="1">MNGLVLTTTVHTQLAIKSMVEKLRQNERGASALEYVGMLLVGAMFVAGVVAAVNKDQVTKWVQGATKVIDGINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS2</accession>
    <name>W4THS2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68485">
        <property type="protein sequence ID" value="GAE68485"/>
        <property type="gene ID" value="JCM18909_1626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15337" checksum="EFCF0744EE70F500" modified="2014-03-19" version="1">MRALGEMLLSNLNYKSFRDIAEDLLGPAGGFIAGWTYWFSWIVAAMGDMAAITAYFQYWWPNIPKWLPATALAAVLLALNIIAVQFFGEAEFWFASSSSSRSARWSLSPSRCWQAASSPLTVIPLLSPTCGMMAVSSPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW1</accession>
    <name>W4THW1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67759">
        <property type="protein sequence ID" value="GAE67759"/>
        <property type="gene ID" value="JCM18909_841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17967" checksum="9B9F28384CC662F4" modified="2014-03-19" version="1">MGSGSFLIAGRDNFTELARGSKPVDSGKINLSAWVDWIKAHKTLKPDFAKRAVSLTTSLHEGTSRDTTFTLGKPADKAVAPDTVDFTSKDAVVNTIMKPRSSRTTRPSTSPPLRLRTAGPPCPSKCRPPRGWSAVRPPSFSPSRIPAPRCASPPSCQYRPAIILVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC6</accession>
    <name>W4TIC6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67899">
        <property type="protein sequence ID" value="GAE67899"/>
        <property type="gene ID" value="JCM18909_992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6546" checksum="410EA74F65484262" modified="2014-03-19" version="1">MSTKTELAFSMTPLASVVEKKISSGSTIRFSPVGSGRDMALLGQYVYVWFKEVLVISPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH8</accession>
    <name>W4TIH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Agmatine/putrescine antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68342">
        <property type="protein sequence ID" value="GAE68342"/>
        <property type="gene ID" value="JCM18909_1471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="13842" checksum="52A55ECCA5E4EE13" modified="2014-03-19" version="1">MMVLALVMFTLANIGQGAAWMIMSDRMQAMAAADGSFFGGFFGKFHPRLGTPVHVNLLSGIVSTLFMLAAMELTGSSADLFNVVLGVAVTTYLFSYLLIIPAAAKLRLSEPDVERPFRAGPNWFSSSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII5</accession>
    <name>W4TII5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68780">
        <property type="protein sequence ID" value="GAE68780"/>
        <property type="gene ID" value="JCM18909_1937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="392" mass="42954" checksum="DA02085083486630" modified="2014-03-19" version="1">MHPRTSGAAMNGDDGGFLAALVDHAETDADEHLDRFLSTFAHLRSDSIEDLRAWATPVAGKRTSRLAQQVFAAANRWARTLEELEHRRETIETSLPELRQKANIPNAGEDDRQAFADAEATITWIHKLRGKATQEYWVATLEEYGLFPNYTLVDDSVELDVSLSWYDPDSKDYQDETASFSRGSAAALRDFAPGATFYAMGHAITIDAIDLGRDGESIHTLAVCPSCGYTVDQLLEGAPTECPRCHDHGIRDTGQHLEVVELTRTSAAIKCDESRIDDAQEERAQTNFTVVPAADIDPSRVRNEWYVQHTEFGARYLDRMDLRWINLGKETPSAPSRQVAGFQCILPCSASAKAADTSTAPPELITAPSTGRGAATAMTSTSTCAQSHSPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ7</accession>
    <name>W4TIJ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67944">
        <property type="protein sequence ID" value="GAE67944"/>
        <property type="gene ID" value="JCM18909_1046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="140"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="307" mass="33306" checksum="9C9CA07B138C4DE3" modified="2014-03-19" version="1">MTYFWLMLAEGLLMAGLVILAMREFAWVIAQRRRAVSGATPSILHSKTLLGEVNARFVRTRPGRWLARELELGGITQPPAVVAAVTILVSILVAVVFYNMLAPALAVVGVLLGLAGLWESVRRSQQRRTAKFVNQLPELARLLANASHAGLSLPTAIAMVSDELGEPARSEFAQVENRLRFGAPLQTALDELASHVRSREVTVLMSTLIVSARSGGSLVTALRGIADSLEERKETRREVTTILSQSLATAYLIIIIGLGLLVALNMFEPGTVELMTHSFVGRICLIAGLSLFAVGFVVIRQMTKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV1</accession>
    <name>W4TIV1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68716">
        <property type="protein sequence ID" value="GAE68716"/>
        <property type="gene ID" value="JCM18909_1869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="12770" checksum="FB011222A3A63DFD" modified="2014-03-19" version="1">MAFDAGSEAVMIASAYYSKIDPGTLGLFSSKIMTDMLRGDFGYQGLIVSDDLGSSVSVFSIDGGHRASKFVSAGGDLAITADPLLAGPMIRALTSTATSASGKKRLVDAASHVINVKLAHSLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIW2</accession>
    <name>W4TIW2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68726">
        <property type="protein sequence ID" value="GAE68726"/>
        <property type="gene ID" value="JCM18909_1880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849103" evidence="2">
        <location>
            <begin position="31"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25401" checksum="C014F3988D8B4E0D" modified="2014-03-19" version="1">MLRNPWFWVLLALVLISAACMVHTYVIVHADTEVGRQGQKGVIPGITNQSLKLAFHYAWPTAAVWSAIFIFLDRFRTRHLHVWFLCFCWGACVATWMSMHVNTWMAGMLSVTGGVDPASGAGPAVYSAPFVEESGKALVLFALAIGMGRRMTSVVQTVSMAGLSAIGFAFVENIMYYARADNYARVTASAGDPKQVVMELVLLRGVYASFGHPLFTSMTGIGLALGLRSRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD2</accession>
    <name>W4TJD2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Permease of the drug/metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68647">
        <property type="protein sequence ID" value="GAE68647"/>
        <property type="gene ID" value="JCM18909_1797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="10798" checksum="6EE1836C6A84EA84" modified="2014-03-19" version="1">MPALLLMAALWGSTLVVMKGVYAHMSPENLLACRFAMAAAAFGILFEAWRANMRTIAKGVILGVLFAAGQLLQAIGLGTTQAAMNGSSPVSMWSSHRYWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE4</accession>
    <name>W4TJE4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68662">
        <property type="protein sequence ID" value="GAE68662"/>
        <property type="gene ID" value="JCM18909_1813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16766" checksum="30B1AA3486A084D6" modified="2014-03-19" version="1">MARTFDPIREMDRLLSDVTRTPATVAVPMDLYREGDDYTVAVDLPGVDPVSIDIDVDDRTLTIRAERAAKVAKEVQWLSRERAMGTFARQLTLGHGLATDRITAEYTDGVLTLTIPVAETAKPRKVEVRHGSTTIDAMTDQAQVGSGEHQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG9</accession>
    <name>W4TJG9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68687">
        <property type="protein sequence ID" value="GAE68687"/>
        <property type="gene ID" value="JCM18909_1838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_C" evidence="1">
        <location>
            <begin position="63"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="234" mass="24562" checksum="3BA3103810688424" modified="2014-03-19" version="1">MTSWHAARAGAIFDVSTPSGERTLELSLPGEFNVRNAAMALAMLEAAGLAFDDVADGLCSAQVPGRMERVDLADDAPTALVDFAHTPQAIASALDAARSSVDGGRLIAVLGAGGDRDVAKRGPMGQIAAERADIVIVTDDNPRTEDPAVIRAAVLEGAHEAAGDGVIVIDGGRRREAINEALRMAEAGDVICVLGKGHETGQNIGSEVLPFDDREVIRAEWKIMARQSEEDQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH6</accession>
    <name>W4TJH6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68916">
        <property type="protein sequence ID" value="GAE68916"/>
        <property type="gene ID" value="JCM18909_2089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="14"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="428" mass="48475" checksum="AA18BBBC8B678BF1" modified="2014-03-19" version="1">MTVDGRPTPADANFVVLADYVTVEDGTGLVHQAPAFGADDLQTCRRYGLPLVNPIRPDGTFEESVPLVGGQFFKTADKPLCEDLDRRGVLFRLEMHWHSYPHCWRCDTHLIYYAQPSWYIRTTKVKEQLLAQNEGTTWYPETIKYGRFGDWLENNIDWAVSRSRYWGTPLPLWRNDDDRSDVICVESLAELSQYVGRDLTGMDPHRPFIDEVTFTRGGHTYHRVPEVADAWLDSGSMPFAQWGYPHVPGSKEKFESHYPGDFICEAIDQTRGWFYTMMAVGTLVFDESSYRNVLCLGHILAEDGRKMSKHLGNILLPIPLMDSHGADALRWFMAADGSPWSARRVGDETIQETVRKVLLTYWNTVSFQALYARANGWSPAQGTQHGADRRGGLWTRGGSGGLSPRCNTASRAGSLARQRHQCAGTRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH9</accession>
    <name>W4TJH9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyridine nucleotide-disulphide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68309">
        <property type="protein sequence ID" value="GAE68309"/>
        <property type="gene ID" value="JCM18909_1437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21372" checksum="E5ADC14A78DFCD05" modified="2014-03-19" version="1">MTDVPGIFAGGDTVPSERTVTIGVGHGKRAARQIDLWLNRESGYPTAKNTTVGFNDLNLWYFGDHLRRHQPELDPTQRVGFDEVVGGLTDDQAHFEAGRCLSCGNCFECDGCYGSCPEDAIIKLGKGHRYEFNYDKCTGCATCFDQCPVHAIEMIPEGTDPATVQGSGNPTPGWAVRPEPNPQRSASLKFTVDSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ2</accession>
    <name>W4TJJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68931">
        <property type="protein sequence ID" value="GAE68931"/>
        <property type="gene ID" value="JCM18909_2106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="40" mass="4058" checksum="591557BA4B96478B" modified="2014-03-19" version="1">MGVTVSRLASGLPVGGDLEYADEVTLGRAFEGRLHVGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJN7</accession>
    <name>W4TJN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68752">
        <property type="protein sequence ID" value="GAE68752"/>
        <property type="gene ID" value="JCM18909_1908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4919" checksum="8B6CB76276B31D98" modified="2014-03-19" version="1">MLRFWFDRGVDGFRIDVANSLVKESGLPDLPEDEKIRRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ8</accession>
    <name>W4TJQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69016">
        <property type="protein sequence ID" value="GAE69016"/>
        <property type="gene ID" value="JCM18909_2197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="9695" checksum="D873DBB65FEA3233" modified="2014-03-19" version="1">MVRNPLAEPYVLGVSAGASSGAATAIILVGISSTFGVASMAFLGALASTAIVLFMGGERNSSTLRLILAGLAVGFVFQALTNFIIFSSDSPETPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR3</accession>
    <name>W4TJR3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69021">
        <property type="protein sequence ID" value="GAE69021"/>
        <property type="gene ID" value="JCM18909_2202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10772" checksum="56BDA496EAAE3AD9" modified="2014-03-19" version="1">MFAANGLRNMYHSNTTRVFDADMEDLLHKNPEWIVLLAGDGAMSKVEPTFLSFKGAKELKAVKKGHVVTMSFALTDPPTPLTITGTEKLHDLIKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ4</accession>
    <name>W4TJZ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68753">
        <property type="protein sequence ID" value="GAE68753"/>
        <property type="gene ID" value="JCM18909_1909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11336" checksum="4303E4A874A84B81" modified="2014-03-19" version="1">MRVIIDLVPNHSSQEHPWFKKKALAAAPGSPERDRYIFRDGRGESGELPSNNWPSVFGSGAWERITEPDGTPGQWYLHFFFDVSQPTGTGRTPTSSKSLTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK12</accession>
    <name>W4TK12_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein-quinone oxidoreductase FixC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69295">
        <property type="protein sequence ID" value="GAE69295"/>
        <property type="gene ID" value="JCM18909_2495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="3">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15241" checksum="062CBE8558BA7FF7" modified="2014-03-19" version="1">MGSQPSESPPPLWDVPGVEPDFDVIVVGGGVAGAVAAYELAGEGHEVLLVERGQEPGSKNLSGGVLYCRVLEEIFPNFLRDAPVERKITRNQLMFLNRDSSVAVDYRDARLMDPVNAVTVLRAKLDPWLSEKNARKPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK45</accession>
    <name>W4TK45_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69171">
        <property type="protein sequence ID" value="GAE69171"/>
        <property type="gene ID" value="JCM18909_2362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="195" mass="22428" checksum="3824D8F586E5D9F0" modified="2014-03-19" version="1">MVNDYLVRRSFNVLYIWIDAILLLAFLCILARTRRHAALVVGLLGGVAYLVVDYGFFYALLRTRTVVGMSVLSLEIWLSFSYGITNMAWMWLWFDEPGNRWEWSILFPAGWLTSALVSQGFGGMFHNVQIARHVSSYHSIMVAFALVGYGWLAMHNLRHPDERYSIRSALIIGIGIQFTWEAVMNLVPRRLLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK57</accession>
    <name>W4TK57_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68902">
        <property type="protein sequence ID" value="GAE68902"/>
        <property type="gene ID" value="JCM18909_2074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9694" checksum="8E7DEE6C476AA33D" modified="2014-03-19" version="1">MNYAGPYQLLVATVLSAQTTDRRVNTVTPTLFNRWPGPQALADADIGDVETVVARWDVDQPEQRALCRWGHSSSTILTVPSLTILTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD5</accession>
    <name>W4TKD5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68614">
        <property type="protein sequence ID" value="GAE68614"/>
        <property type="gene ID" value="JCM18909_1761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="186"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="218"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="417" mass="44777" checksum="5FE8E46AA576D7E1" modified="2014-03-19" version="1">MLLACPLIPTLIGGFVKLFRKRSSDSRRERARLIARYLDALSNLVLIRMLGAGQRVEDDLRRRGETNRGTIMKLLAGNQIVIVVVDGLFSLLFIAMAAGLAMTRWQGGDISATSAITIVLLSVLLLEPLHQVAAFFYVGMGGIASQKALRKWFDAAPSALMTSDSASSTPTPQRSAHVPVPEDGTIRLRNVSVGYGETEVLHGVSLDITHGGRTAIIGRSGAGKSTLLSVLSGTLPPKSGEVYVGGLDALTAAPGEIRSISASVNQRTWLFAGTVADNLAIANPNATREQMWDALRRAGVADDVEAMPKGLDSDVGEQGRLMSGGQAQRISLARAFLSGRNILLLDEPTSHVDVDSERRIIDAISQIGDNTTIVMVTHRRRLLRLAHDVQRVSAGTLSPADDVDSIEDDRTETEDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL3</accession>
    <name>W4TKL3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine-N-acetylmuramyl-(Pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68699">
        <property type="protein sequence ID" value="GAE68699"/>
        <property type="gene ID" value="JCM18909_1850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="69"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="235" mass="24650" checksum="2A8FC04D9AAD54AB" modified="2014-03-19" version="1">MPGLANKIAARFAVFVGTAFPDTPLPKARFVGMPLRSQITDLADASGQARAERCVRARADLGLDINRPTLLVSGGSQGAVAINEAVVAARTRLLADGVQILHVLGPKNIRGATRITDELTGASWLPVGYVDDMASAYAAADLMVARSGAGTVVETATVGLPTIYVPLPHGNGEQARNATSAVDAGAGVVVANADLDVERSLQRLPASMMLMLLPRCQRRDGDSCPLTLLRRWRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL7</accession>
    <name>W4TKL7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69072">
        <property type="protein sequence ID" value="GAE69072"/>
        <property type="gene ID" value="JCM18909_2256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4358" checksum="D5D4D20C6D476D43" modified="2014-03-19" version="1">MLARMPARQRAEMGVQVALAADAVESIITQGLAAAQNRFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS7</accession>
    <name>W4TKS7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="13" type="ORF">JCM18909_2321</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69132">
        <property type="protein sequence ID" value="GAE69132"/>
        <property type="gene ID" value="JCM18909_2321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE69132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13589" checksum="15D1A74EB75E4C57" modified="2014-03-19" version="1">MSASKCRRVINLVRGMDAVDAVTMLKFQPQAAAEPIRKVIASAMANAEQTEGLRADDLYISQAFVDEGITMRRIRPRAKGSASRILKRSAHITVVVEPKEARRARKKAKSGRPAAAAKSETEKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV8</accession>
    <name>W4TKV8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69401">
        <property type="protein sequence ID" value="GAE69401"/>
        <property type="gene ID" value="JCM18909_2610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9380" checksum="E9F6299218B6A717" modified="2014-03-19" version="1">MALTIACLVIATTRHLAMMRRWSIILVAVEIYQSIVGYSQYFAHLNPWLVIWHMVGVSLAAAAVGALWCSVRPTPSPVLNRQSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL14</accession>
    <name>W4TL14_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69660">
        <property type="protein sequence ID" value="GAE69660"/>
        <property type="gene ID" value="JCM18909_2905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20001" checksum="77EE8A8D8A6CA0C4" modified="2014-03-19" version="1">MRIASFNINGIRAALKRGFSEWMEARDCDVIGLQEVRCRPADLPEGAFGDRHVSWAPGSLAGRNGVALLTRSAPTEVRSWGTHLVMTPGQAPTLAQVLTGNTDGLPTELLPFADEGRYIEIDLADTPLTVACLYLQRRYPGSSQRESPRQAGPQNGLPGRVPRPPSPTPPRMHRPRPSLPRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL21</accession>
    <name>W4TL21_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription antitermination protein NusG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69670">
        <property type="protein sequence ID" value="GAE69670"/>
        <property type="gene ID" value="JCM18909_2915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="6">
        <location>
            <begin position="112"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="311" mass="34904" checksum="0CF2EDF52A47FAEC" modified="2014-03-19" version="1">MSDSPHFSETDDVEINLDALTPDTAEEKDDEVEIDLGDLSEEDSAEEPEINLDLGDDESAEASDDDIARNLGIGQAADDEEDADEDESSEADNQDAIDAAIEELRDELSSKFGEWYVLHTYSGMENKVKQNLDARVQNFNMEDYIFETVVPTEEVVEIRNGARRTITRVYLPGYVLVRMDLTDDSWGIVRHTPSVTGFVGQSTTPIPLTFDEVVKMLTPSVVARVSHENADKLLRRRLSQRLRLPITRSANRCRSLMVLSLVSQPRSRRSTRTTSALRLWLRSLAAPPRWTSSSTRSRRSEPDFGPTGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL56</accession>
    <name>W4TL56_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter NhaA type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68894">
        <property type="protein sequence ID" value="GAE68894"/>
        <property type="gene ID" value="JCM18909_2066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8765" checksum="E308A23B8F182D29" modified="2014-03-19" version="1">MDSPNLAGYRLRLILGKVIGITLGSCLTARFTSAELGRGVVWRDIIAVAMLAGIGFTVSMLMTDLSFPKNHEFANEAKHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE5</accession>
    <name>W4TLE5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Epi-inositol hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69566">
        <property type="protein sequence ID" value="GAE69566"/>
        <property type="gene ID" value="JCM18909_2799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6854" checksum="7E66C3219242D77C" modified="2014-03-19" version="1">MRLTCTGPTHLHRWWDVPVTSQSRLESTQKAYAEYTGQVAAQRRFFLTASPISGWGLGDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF0</accession>
    <name>W4TLF0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-keto-2-deoxy-D-gluconate-6 phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69571">
        <property type="protein sequence ID" value="GAE69571"/>
        <property type="gene ID" value="JCM18909_2804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5673" checksum="089EF0FDDBE67578" modified="2014-03-19" version="1">MSTDPGETRRRWATALAARHVRGLVLGRSVLYPPDSDVATAIDNAVQLLGVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH2</accession>
    <name>W4TLH2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69288">
        <property type="protein sequence ID" value="GAE69288"/>
        <property type="gene ID" value="JCM18909_2488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="254" mass="27650" checksum="B3BBCECC8B1300D6" modified="2014-03-19" version="1">MFMEPSRSTITALEVLGALSEHVEPQYASALARRLGIPRTTTYRILAALVSEGYAVHDSELGRYSLGPAAYELAAAYQRQEPLRRVSLPIIDHLVDETHSSIHLALLRGSEVIYVVEQRGIHTPSLITEVGVRLPAEITASGRAMLSCLSWTQVDALYPSSVELSAGHSNSPTSTTELHAMLAETRKRGWAREIDSVTVGWSTLAVPVVDVSGYPLASLATTYRTALESSQLDQALLDHLFAAARAIQYRLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ6</accession>
    <name>W4TLJ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69855">
        <property type="protein sequence ID" value="GAE69855"/>
        <property type="gene ID" value="JCM18909_3114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8482" checksum="B43DC3AE77F8B3C9" modified="2014-03-19" version="1">MEAAVLSRICEPERQIIFRVPWVDDEGKVRINRGFRVEYSSVLGPYKGGLRFHSSVYLGTIKFLGFEQIFKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL0</accession>
    <name>W4TLL0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Magnesium and cobalt transport protein CorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69049">
        <property type="protein sequence ID" value="GAE69049"/>
        <property type="gene ID" value="JCM18909_2231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13589" checksum="60B011DABD6F62E5" modified="2014-03-19" version="1">MQRIPDELSSLRWTPRLPKDEELLRHGPESVLYTILDGVVDQTFPVISGIQFDIEQIERQVFSGDSAAPERIYRLSREAIDLQHATNPLIPVIAALRLDRPNTKFPQNCRPTWPTSPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP4</accession>
    <name>W4TLP4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SSU ribosomal protein S7p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69099">
        <property type="protein sequence ID" value="GAE69099"/>
        <property type="gene ID" value="JCM18909_2286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="11371" checksum="D0026A577C6B0009" modified="2014-03-19" version="1">MQTLKRALDNIKPSLEVKSRRVGGATYQVPVEVKPARQTTLAMRWLVNFSRERREKTMAERLMNEILDASNGLGASVKRREDTHKMAEANRAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX8</accession>
    <name>W4TLX8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding protein EngA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69199">
        <property type="protein sequence ID" value="GAE69199"/>
        <property type="gene ID" value="JCM18909_2392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="210" mass="22778" checksum="58667741516AF5B6" modified="2014-03-19" version="1">MSDSPEFRNDPSDDIEEALPKPVVAVVGRPNVGKSTLVNRILGRRAAVVQDVPGVTRDRVSYDAEWSGRQFVLVDTGGWASDASGMAAMIAEQAELAISTADAVLFVVDANVGTTDEDEAVVQVLRQSRKPVVVAANKVDNARGESEAATMWNLGWGSPTPFPPCTDAVQVTFLMRSLRYCRRSRLATSHRTDRVGSPLWASRMSASRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY2</accession>
    <name>W4TLY2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="5 10">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_3256</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 10"/>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69980">
        <property type="protein sequence ID" value="GAE69980"/>
        <property type="gene ID" value="JCM18909_3256"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0521">NADP</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="277"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE69980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="361" mass="38114" checksum="CEC0CAC59B29B5B4" modified="2014-03-19" version="1">MDIVIELIGGIDPARQLLTAALGKGHSVVTANKALLAAHGTELHAVAESNGVDLYYEAAVAGAIPIVRPLRESLVGDQITRVMGIVNGTTNYILDQMTTTGARFDEALAQAKAQGYAEANPTADVEGYDAAAKAALLSSLAFHTQLRGDQVYREGITEITPDDILAARDMDCVVKLLAVCQAGPDGISARVHPALVPATHPLGSVSGAFNAVFIEAREAGRLMFLGPGAGGSPTASAVMGDLVTVARNLVRGVAGPPQDVYGEFPILLMSEVHTRFHLRLQVRDEPGVLAEVAKIFASHSVSLQTVQQSAVEGTDRADGWSATLKVLTHEARECDVDECVNELTGHHYVNSDPRVIRVEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY3</accession>
    <name>W4TLY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69204">
        <property type="protein sequence ID" value="GAE69204"/>
        <property type="gene ID" value="JCM18909_2397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022296">
        <property type="entry name" value="Proteasome_asu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF69">
        <property type="entry name" value="PTHR11599:SF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03691">
        <property type="entry name" value="20S_bact_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="226" mass="24340" checksum="AC15709518B4FB86" modified="2014-03-19" version="1">MMTVPAYVPPSEWVTDRSTFVSDSIRNGGDGIVVARCADGIALLARQCGADLSKGMRSVSEIHDRLAFAAVGLFHEAEELRVAGIRFADLRAYAYGRLDVTGRSLASMYARIIGKTFARINVKPYQVQVTVAELGLVPSEDRFYTIDFDGSVHAGTGPILMGATGENFLDLPNNAPISEVVRAAGHVLDVEPANLEVGLLDRHASTHRHFRRLDAATVLEADGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM07</accession>
    <name>W4TM07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major myo-inositol transporter IolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69562">
        <property type="protein sequence ID" value="GAE69562"/>
        <property type="gene ID" value="JCM18909_2795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="519" mass="56382" checksum="339A867BB1B3FDEE" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM24</accession>
    <name>W4TM24_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosynthesis protein MoaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69791">
        <property type="protein sequence ID" value="GAE69791"/>
        <property type="gene ID" value="JCM18909_3043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8212" checksum="AACE9EEEE11A720E" modified="2014-03-19" version="1">MSAATGQSATHHGLPDRFGRLATDLRVSVTDHCNLRCTYCMPAEDMDWLANRDLLTDERSSVSLASGSSDWASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM45</accession>
    <name>W4TM45_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69602">
        <property type="protein sequence ID" value="GAE69602"/>
        <property type="gene ID" value="JCM18909_2839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14305" checksum="7402F246CE425E2C" modified="2014-03-19" version="1">MASALANPHRRSALDTATTPQEVVSILSNEAGHRSTEASTSQNLLLTVCGNGLGTSLFLKNTTEQVLDAWAWAPYLSVEATDTISARGRCIEADAILTSGAIAQTLGELSIPVEVIDDFTSVSQVDAALRRIYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM88</accession>
    <name>W4TM88_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69647">
        <property type="protein sequence ID" value="GAE69647"/>
        <property type="gene ID" value="JCM18909_2891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFOR_II" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14289" checksum="2EFA95200E855CB3" modified="2014-03-19" version="1">MKGIAKTIPPTAVDDPSGDADVLVLGWGSAYGPITAAVRRVRARGLSIAQAHVRHLNPLPEDLGDVLRRYRQIVVPEMNTGQFAMLLRSKYLIDVKTISRVRGLPISPVDLCDELCRHCGDSKGSDDTREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA2</accession>
    <name>W4TMA2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ORF">JCM18909_3110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69851">
        <property type="protein sequence ID" value="GAE69851"/>
        <property type="gene ID" value="JCM18909_3110"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="267"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="407" mass="42372" checksum="56AD08C407757034" modified="2014-03-19" version="1">MKKVIILGSTGSIGTQTLEVISSRRDQFEVAGISAGGSDVGSLAQQIIDFSIPVVAIAREDAAEELQRALTVQAGSRGLVVPNPRILTGPDASTELAAMPADVVCNAITGAAGLRPTLATLAAGTTLALANKESLVIGGRLVTQAAASGQIVPVDSEHSAFAQCLRGGGRNEVRRLVLTASGGPFRGRDRASLADVSAAEAMKHPTWNMGRVITINSSTLVNKGLELLEAALLYDVDLDDITVVVHPQSIVHSMVEFWDGATIAQASPPDMKLPIALGLSWPDRLPDAATGCDWSTATQWTFEPLDNDTFGAVELARRAGHAAGTAPAVFNAANESCVDAFCAGSIGFLDITDTIAAVLDEHLSGDENDTLGARHVGVEALTLDAVLAADAWGRRRAAEVCARGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB6</accession>
    <name>W4TMB6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69334">
        <property type="protein sequence ID" value="GAE69334"/>
        <property type="gene ID" value="JCM18909_2538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035169">
        <property type="entry name" value="DUF5318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17249">
        <property type="entry name" value="DUF5318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="133" mass="15271" checksum="4089D2D22F837087" modified="2014-03-19" version="1">MVSHALQRRHTLEALRSPQVDLSAPTACDADPMLVRAAMHHDEPLNHDCPVCESPRLALLRHAFGHQLGQYSGRIRTLDELEEMEHQFGEFHVYEVEVCPDCLWNHILVDYVLGDGRRRRPPCHQPTVEDIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME6</accession>
    <name>W4TME6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69583">
        <property type="protein sequence ID" value="GAE69583"/>
        <property type="gene ID" value="JCM18909_2817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="335" mass="35898" checksum="72C604C14735A93E" modified="2014-03-19" version="1">MSRGSRPTQVDVARLAGVSRQTVSLVVRDDPRVAEKSRRSVREAMRALGYYPNMAARVLAAHTTRVVGVVIAQLTNPFNAELAEALRGACERVGLVPFVSPVSDERGDVLVAVRRFLQLGVDGLLLVSPLATDEELDEIGRQVPTVVLIRNAGPASVDLVRVDDAAGGRLVAEHLVASGYCPVVHVGSDRYVHGDSTSERRAGYRLVMASIGQEPMEISMDGADLKETIARLVVRNRRFALCCHNDVTAFAATGCIRALGLRPGADVGITGFDDTSISSLPGIDLTTIHAGIPDIARCAVDVLGERCEGRRQPRDVVLPHSLVVRGSSRCPDNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF1</accession>
    <name>W4TMF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69891">
        <property type="protein sequence ID" value="GAE69891"/>
        <property type="gene ID" value="JCM18909_3156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018833">
        <property type="entry name" value="DUF2437"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10370">
        <property type="entry name" value="DUF2437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2437" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20661" checksum="9E6F984288F40CA8" modified="2014-03-19" version="1">MRIARFVTAGSDPVFGIVELAADHGDHPETIAVITGDPVAAPVQYTGARHDLADVRLLSPVIPRSKIIGVGRNYADHASELGNEVPHQPLLFVKPNTSVIGPDEPLCDRLRPPTCTTRGSWPLLSDGSVRTCQRTELRKSSLGSPLPMTSLPAICKILTVTGFAPRGLTPSARWGHGWLPTSPLQKRLTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF4</accession>
    <name>W4TMF4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2828</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69593">
        <property type="protein sequence ID" value="GAE69593"/>
        <property type="gene ID" value="JCM18909_2828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11393" checksum="96A50C85082A5237" modified="2014-03-19" version="1">MRHDERHIMKRLTGTVRTYSWGSYDAIPDILGKEADGKPWAEYWLGAHETSPSTLDGIPLTDYIHAHPDELGDRSRKNLRCPLTLSPQNPLSPPPVKSASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ6</accession>
    <name>W4TMQ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na+ efflux ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69459">
        <property type="protein sequence ID" value="GAE69459"/>
        <property type="gene ID" value="JCM18909_2675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="403" mass="43914" checksum="C84119B99EB716CC" modified="2014-03-19" version="1">MTNTSSAWRLVASREVDVKLRDKGFIISMIITVLLIVAISVVLSIISSKHDHDSVVVTDDKAAAIVKVAQQDLDARGSTDKTEVVRAADEVEAHRKLQSDDNTVYLHQKDGQWHLDGYDKTPSVDRSSIGAVERAVAVAAVADNAKAAGADASTMTKGMSLQAGQVKPSDGTSEAVGYMLAIVFSVLFMMSAIYYGVMIANSVVEEKQSRIVEILLTGVPARQLLIGKIVGNTVLAVGQLIIICGLSMLAVSFSQWSDIITFAMSWSVMWFLLFFLVGFVALASLYAAAGSMASRSEDVQNTTSPLMYLIMIIYFWVVFSMSNPDGMSARIGSYAPIASVVFMPLRMLGHRAQWWEPIVSIFVTLGFTVFAVLAGERIYRRSILQTNGRVSFKNAWKQNESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS8</accession>
    <name>W4TMS8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69723">
        <property type="protein sequence ID" value="GAE69723"/>
        <property type="gene ID" value="JCM18909_2972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28279" checksum="07819430FD97C5F7" modified="2014-03-19" version="1">MAVAAHLWQDHVINRVIVVCPTDHLRSQWIAAARGLGLDLRDTTNAEALPPDCHGCVVTYAQVAQKPALHAARATNMRTLVIFDEIHHAGDVMSWGSGVIEAFSGAVRRLGVTGTPFRSDEARIAHVRYEEVSDGAFESVADYTYGYGDALRDGVVRPVTFATYTGRSTWTDAVGETHTAILGDSELTKAHEEMAWRTALDSDGEWIAHVMAAAWARVSQLRESGTIPHARCLSQPLIRRLLRNMPKSGETLPAMNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT2</accession>
    <name>W4TMT2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70290">
        <property type="protein sequence ID" value="GAE70290"/>
        <property type="gene ID" value="JCM18909_3598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="30819" checksum="F388EF6EAF13FEB4" modified="2014-03-19" version="1">MSSLEHRLSKVSETLDRMHPSGLLYTTYEARLLDQLDRSRLPQHVAVLADGNRRWARLNAPGEPLVTGYEAGADRLREFCTWCDAVGTPIITLWVLSTDNLQRAETGELGPLLKVIESLVDSLAANSRWRVQAVGDLDLLPDDMAESLCRAGRTSAGHVGMHINVAVAYGGRHELRDAVRSLLAEEAEKGTSLADLARTLEIDQIEDHLYTRGQPDPDLIIRTSGEQRLSGFLMWQSAHSEFYFCEALWPDFRKVDFLRALRSFTQRERRYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN12</accession>
    <name>W4TN12_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69803">
        <property type="protein sequence ID" value="GAE69803"/>
        <property type="gene ID" value="JCM18909_3058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="71"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="14952" checksum="7091EE9616D7105C" modified="2014-03-19" version="1">MLILTTFDLDEYVYAALKAGASGFLLKDARPTELLSAIRNVADGDAVVAPSATRRLLDHVVPTLPNDPKAADKRLSVLTDREKEVLVEIAKGATNAEIAQTLYMAEGTVKTHIGRLLSKLECRDRVGLVLFAHEVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN31</accession>
    <name>W4TN31_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2852</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69614">
        <property type="protein sequence ID" value="GAE69614"/>
        <property type="gene ID" value="JCM18909_2852"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="15983" checksum="3DAFEC862384C857" modified="2014-03-19" version="1">MARLPESLSAESLLARTVRGIRGADAKALEAARARQQLLTKPEGSLGLLEDLSIRLAGMYGQVPVTVPSHPVVGLFAGDHGVWAQGVSPDPQEITTQQMINMAAGGAAISVLSRQMGAQLWITDVGARHEVDARSASGVCAAALMTFLRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA1</accession>
    <name>W4TNA1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69694">
        <property type="protein sequence ID" value="GAE69694"/>
        <property type="gene ID" value="JCM18909_2943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="193" mass="20254" checksum="69DCD3E60C7207AC" modified="2014-03-19" version="1">MHAMTPIRRPGATVVQAIGGTAKGNLLLDSPELCRQLAERIGCAYRVMPAPVLVSNPQAAAALKAEESVGMTIAMASHADILVTGVGAVGMHSVAPIFDHVMSERAHAELLSRGAVGHICGHHVDTRGRHIDAGFCQGLMAVPLDRIPSITHVIVSAFGSEKVPALTAILRGKWVTDLVTDIATARAVLDHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG5</accession>
    <name>W4TNG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70500">
        <property type="protein sequence ID" value="GAE70500"/>
        <property type="gene ID" value="JCM18909_3827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10022" checksum="7AEC181C52E54273" modified="2014-03-19" version="1">MSKPEVNPEEINKGTLVAVAVAAVAVIGIALTATRKGPKDRKTGSQDPSLFENLATRKPSGGRVTQRRDPRADGHATPMGGTGRVSTAPDFYSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK2</accession>
    <name>W4TNK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Siroheme synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70316">
        <property type="protein sequence ID" value="GAE70316"/>
        <property type="gene ID" value="JCM18909_3630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="235" mass="24701" checksum="7CD4499460B0F07C" modified="2014-03-19" version="1">MTDPLASGTPLVIAAHGTRDEAGVAECRALAERVARKLPGIPVELGFVELAEPGIPEAVRAAVAQAPDNPEGADGDEEAAAVVVPLMFNTGGHVREDIPEAIDEGRGDARVMYSAPLLPDVRMRKALNHRLTETLAAGEGREEWRPRDTSAVLVGRGALVPDANASHYTLTRMFWEEKRPVVGRAGFHSGDSSVSPGSLVCLSSAGGRPDRRAGQFLVPRPATCVDDRTGGGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNS2</accession>
    <name>W4TNS2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70048">
        <property type="protein sequence ID" value="GAE70048"/>
        <property type="gene ID" value="JCM18909_3332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8010" checksum="566CCA65BA01485A" modified="2014-03-19" version="1">MRALTGQIQHYDWGSTDAIPAILGARPDGTPWAEYWLGAHPKAPSALPDGTPLDQWLTHHRRAGSWEPRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX6</accession>
    <name>W4TNX6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Mannonate dehydratase</fullName>
            <ecNumber evidence="5 6">4.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-mannonate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxuA</name>
        <name evidence="7" type="ORF">JCM18909_4061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the dehydration of D-mannonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O</text>
            <dbReference type="Rhea" id="RHEA:20097"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17767"/>
            <dbReference type="ChEBI" id="CHEBI:57990"/>
            <dbReference type="EC" id="4.2.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the mannonate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.8" evidence="5 6"/>
    <dbReference type="EMBL" id="BAVM01000065">
        <property type="protein sequence ID" value="GAE70685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70685">
        <property type="protein sequence ID" value="GAE70685"/>
        <property type="gene ID" value="JCM18909_4061"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008927">
        <property type="term" value="F:mannonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00106">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004628">
        <property type="entry name" value="Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30387">
        <property type="entry name" value="PTHR30387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03786">
        <property type="entry name" value="UxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016049">
        <property type="entry name" value="Man_dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00695">
        <property type="entry name" value="uxuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="357" mass="40309" checksum="AB18FF9F7FF74E56" modified="2014-03-19" version="1">MKMTFRWYGPETDPITLENIRQIPGTSGIMGAMDWIPVGEVWSDEEISSYVQKVNEADLECEVIESVNVHEDIKLGKPSRDIYIANYCKTLENLAAHGIKVVVYNFMPVFDWLRTELFHRNEDGSTCLYYDHEELVGLTPQDIVKATLDSSAFPLPGWEPERLADLDEVMAQYTDMTRDQLRNNYRYFLEGIMPTCEKVGIRMAVHPDDPAWDIFGIPRIVHSDSDLQRIIDLVNSPANSLCVCAGSLGSNPDNDVPAILSKYGDMGRVAAAHVRNVKFLGSKKFKEASHLSSDGSLDMYAIMKSIHDHCSNAYIRPDHGRMIWGEKGRPGYPLYDRALGITYLNGLWEAIEKASTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY2</accession>
    <name>W4TNY2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70252">
        <property type="protein sequence ID" value="GAE70252"/>
        <property type="gene ID" value="JCM18909_3555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850855" evidence="2">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9322" checksum="EF84D13F7213AD74" modified="2014-03-19" version="1">MGTLLNNLFAASRFAGPLFDHSAASLPSASSVMRSSNARASSDGSPSMEAPVAVMATTPAHQVTKTPSTTARTTVRALQVRQTMSLLTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP70</accession>
    <name>W4TP70_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70511">
        <property type="protein sequence ID" value="GAE70511"/>
        <property type="gene ID" value="JCM18909_3840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="299" mass="32944" checksum="98F0E02E88D4995C" modified="2014-03-19" version="1">MRRERALRDVAIGWAVAVWVGAPLAVWEILTARHLGTYADGAWRNHPGLYRQPATWLTNPNLYAVFLAIGSVWVGVVGLRSATRWVRIAAVATTVTGLGLLFATDSRIVYAALLLAVMVRLWAVRRWRWVLPRVVMAVVVAIVVTHLHQAGLVWHRFIGVLIHHNDEGPSSFAVRTTLLAWGLALVMEHPLLGAGPGGYRANILAAPKRWFPHGKTDPHNGILEIASQYGLVVTALVAVCWCLAIGRCWRSRRWWGAALITAMPVLSLANSTYLVQSVNQLGWLVCVLAASSSRQETPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP90</accession>
    <name>W4TP90_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligopeptide ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70014">
        <property type="protein sequence ID" value="GAE70014"/>
        <property type="gene ID" value="JCM18909_3294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850860" evidence="2">
        <location>
            <begin position="33"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="100"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="560" mass="60961" checksum="7C5AAF125A9EEC84" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPC3</accession>
    <name>W4TPC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70258">
        <property type="protein sequence ID" value="GAE70258"/>
        <property type="gene ID" value="JCM18909_3561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6625" checksum="0B83E2D83A75F0A2" modified="2014-03-19" version="1">MIWTGELAEDLLNKGCADAVMVGRAALRDTNWPLRAAHELGVPNEEAPWHPARFRGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPD4</accession>
    <name>W4TPD4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribose ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_3349</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70064">
        <property type="protein sequence ID" value="GAE70064"/>
        <property type="gene ID" value="JCM18909_3349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="18"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE70064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="530" mass="55721" checksum="CB0DE68F4EA48236" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPL5</accession>
    <name>W4TPL5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lon-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S16.012"/>
    <dbReference type="EnsemblBacteria" id="GAE70447">
        <property type="protein sequence ID" value="GAE70447"/>
        <property type="gene ID" value="JCM18909_3772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="6990" checksum="E0056900006C2AF9" modified="2014-03-19" version="1">MLRIGGIQEKIAGAERDGAKIFLVPAGNCRDISGVETSMRLVKVSSLKDAIAAIQKIRAGGTGIPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPN4</accession>
    <name>W4TPN4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70477">
        <property type="protein sequence ID" value="GAE70477"/>
        <property type="gene ID" value="JCM18909_3804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="256" mass="29032" checksum="E7599544D17B19AE" modified="2014-03-19" version="1">MRACELTPALRQRLDEIGAQISQGVGKGLDEAMGRQAASRFVAWMTDTWTRTMSRDEHGVFVVTGDIPAMWLRDSSAQLWPFLIMCDLPEVARQIGDVIARQWHCIDVDPYANAFNSGPTGAHFDADDLDVADELWERKYEVDSLAFPVDLAWRYWQASSSSEHLNGAVHQGCIRIIDVWSLEQDHARSTYRHVRPARAVRHPRPRRFGHPGGTHWDDLERIPTFRRRLSLRLQHSGSVHGDACPASNSRVLSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPQ4</accession>
    <name>W4TPQ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase with transcriptional repressor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70388">
        <property type="protein sequence ID" value="GAE70388"/>
        <property type="gene ID" value="JCM18909_3706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="194" mass="20217" checksum="FD554ACF95271373" modified="2014-03-19" version="1">MTIGSVAGVVDPDLIVVAGPTSRSLDVIRQVIARLHQRRVPGSVPVPAEVAALDRAASVVGAVDVALGHASAAFLGVERPHPVALQGVERILQEVEKGHHSVMATTRDKRTIEVLRVGVVGVGARSRLALNAELEGNGGAIVAVCEPHHLARRRVADRLGKDPDSIVITSDVAGLIRAGIDVAFVTSLTTPTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPS1</accession>
    <name>W4TPS1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70522">
        <property type="protein sequence ID" value="GAE70522"/>
        <property type="gene ID" value="JCM18909_3855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6850" checksum="3C9D6C62DFC307B1" modified="2014-03-19" version="1">MRCFSEHHCATFTDTRVEFNHYNVFKLWDFSKDTIFDFTGLNPYSTNFFICRSARPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPS4</accession>
    <name>W4TPS4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmI</name>
        <name evidence="7" type="ORF">JCM18909_3527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70229">
        <property type="protein sequence ID" value="GAE70229"/>
        <property type="gene ID" value="JCM18909_3527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7894" checksum="D81E3ED2DD6D5E24" modified="2014-03-19" version="1">MELSMPKMKSHSGTKKRFKVTGSGKVTARKAGKRHLNEHKSSRVTRRLTGETVLSKGEAAKVKKLLAGHPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ13</accession>
    <name>W4TQ13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cobalamin biosynthesis protein CbiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70319">
        <property type="protein sequence ID" value="GAE70319"/>
        <property type="gene ID" value="JCM18909_3633"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_N" evidence="8">
        <location>
            <begin position="277"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="376" mass="39128" checksum="0FA4C57E8B32AD33" modified="2014-03-19" version="1">MIRVHGYLGTISDALREEVTQADLVVGGQRHLDALAVPADKRQKLGLIGPAIERIQSLPDDANVVVIASGDPLFFGVVRRIRQAGLRVEVVTAPTSLQAAFAAVALPWDDAQFVSSHSKDIETAVRLAKIHPKVGVLTAPNRGLAELVDGLAGRGKTFVLAEKIGEEGQRVRVLDEDAAKAVIADEDILSPNVVLVLEHHPDSPEALGVNPELAGDVNVNGPDAPQPGSDTNPDGSDRDPIIGQIINSDAAVAHAEAIDHALKRETKKYVGPSRTGLAAAWGECDLIISHLALGATTRIIAPLLESKKTDPGVVVVDEAGRFAIPLVGGHVGGANELSRTVAEALSGTAVVSTATDSLGVPASTSLAGPTRVMSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ15</accession>
    <name>W4TQ15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70627">
        <property type="protein sequence ID" value="GAE70627"/>
        <property type="gene ID" value="JCM18909_3985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4939" checksum="B28761A45F8756C4" modified="2014-03-19" version="1">MMVLYRLLASTRADHTRIDFDAERIRALEELHRTQEDEHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ27</accession>
    <name>W4TQ27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70334">
        <property type="protein sequence ID" value="GAE70334"/>
        <property type="gene ID" value="JCM18909_3648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16784" checksum="DE55FAA690DCD946" modified="2014-03-19" version="1">MTPAPTPPAASLTVGAKSSAGPGSYVLWIKAENRVYLVHNGLVKRVMLTTAEPWKTPVGNYKIQYKTRHAAFTEDGIRWYIPNFLSFFYQRPGATERSVSTRFPGTKRRRNLPSLSTPWDCPDIQVTAVLGWPPKILRPSTNLLMRAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ86</accession>
    <name>W4TQ86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lanthionine biosynthesis protein LanB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000052">
        <property type="protein sequence ID" value="GAE70553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70553">
        <property type="protein sequence ID" value="GAE70553"/>
        <property type="gene ID" value="JCM18909_3894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="40" mass="4671" checksum="0633836139EC7E3E" modified="2014-03-19" version="1">MSRPELYVTFSEFLPSEADYTQNGSRPSYAEEYFIELCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQA0</accession>
    <name>W4TQA0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70399">
        <property type="protein sequence ID" value="GAE70399"/>
        <property type="gene ID" value="JCM18909_3717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="237" mass="26738" checksum="FF33F187315770B7" modified="2014-03-19" version="1">METQRRQRRRQTQEGDMSGHVVFRDMRPEDVKVITFGEPGSLIDRVDRPDVVARVALYENRIVGYAVSWLAVVHRTRRFIDVEVHPDSRGHRIGTRLVRQIQQRVDRPLATKAIAGSDAESFILSLGGEVYTSCPPFELPRRHFGRAVEVLEGASLGPGGAISGATLAPGVLEMLWEQMYVWMHASWSPVDDSEAAHEALRQELEDLDSEATRVALVDGQPAAVAFVFLWTRTRPWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQB5</accession>
    <name>W4TQB5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70593">
        <property type="protein sequence ID" value="GAE70593"/>
        <property type="gene ID" value="JCM18909_3943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12032" checksum="41D9E7D3D54B5A94" modified="2014-03-19" version="1">MLASGAAIADRAKHGPMMTSPCDDRRDPRAMTLLGHIAASEEGAGAKNNDMNVKIAMPTGATKIAGVSGLKRSYPRCDVDATRCETPHQIVGTAMITDDRHPKIAGLGATPASYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQW4</accession>
    <name>W4TQW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70634">
        <property type="protein sequence ID" value="GAE70634"/>
        <property type="gene ID" value="JCM18909_3992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8770" checksum="5F22909FEA3E0EC9" modified="2014-03-19" version="1">MQQPLILLVPGYWLGAWAWDEVVDNLNAVKVLATALTLPGLDPEDTQRTTRTLDDQADAISAILDEMGGDVVLVGHSGANGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDK3</accession>
    <name>W4TDK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_55</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67025">
        <property type="protein sequence ID" value="GAE67025"/>
        <property type="gene ID" value="JCM18909_55"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="317" mass="32360" checksum="33904C0F0B42F68A" modified="2014-03-19" version="1">MVVCCATGIGGLHSLLGQWDIQKDKGFKRVSPFTVPMLMANAPAANIGLMVHAKAGVHTPVSACASSSEAISLGLDQLHLGRADIAVVGGAEAIIHPLPVAAFAQMKALSTRNDDPEHASRPWGVDRDGFVIGEGAAIMVIETLEHAQARGAKIYGSLAGSGISADSHDIVQPDPTGSGQASAMHKALASAGLSPSDVNHVNAHATSTPLGDTAEAHSIAAVLGKATDQVLVNGTKSMTGHLLGGAGALESFAAVMALLKRQVPGTINVEHLEEGLEVNVVTETTDLPDGDLAALNNSFGFGGHNVTLAFTNTNATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEC3</accession>
    <name>W4TEC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67136">
        <property type="protein sequence ID" value="GAE67136"/>
        <property type="gene ID" value="JCM18909_176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021443">
        <property type="entry name" value="DUF3093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11292">
        <property type="entry name" value="DUF3093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5732" checksum="3D86D7AEB2A95442" modified="2014-03-19" version="1">MRLADPADPHQAWIVSTRRPDKLAAIVGEYVVVPGSPSSSENLSENSMEDNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEI8</accession>
    <name>W4TEI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67206">
        <property type="protein sequence ID" value="GAE67206"/>
        <property type="gene ID" value="JCM18909_249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008492">
        <property type="entry name" value="DUF774"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028754">
        <property type="entry name" value="UCP028754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="338" mass="37029" checksum="B40755BE7A1459BD" modified="2014-03-19" version="1">MDRQSNRFSWHPGIVGPDQEVSALITLVQSFSDTGLVQARVRDAIFSQLPHHELGEFDIDLLLDHRDSRQPIIFDTDHFEGYERPRLVLHEVTDQLGQAFLVLEGPEPALGWESLVSSLTSLVDSMGIRLTVITDSIPIPTPHTRPAIVTRWASRPELILGSTSPFGRLQVPASFPVVLGQRLGETNHAVIGLASHVPHYLADLDYPESARALVEALRGATGLALPINSLAVAANTVRAEIDTQVNNSEELKAMLHALEEQYDSRVAQRELGTTQVAVPDAEDIGAEVEDFLRSIDEDDGPSNDDPGTQGSGPRRSSDDTSHDDKPDYHPRRGGDLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TER8</accession>
    <name>W4TER8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase GroES-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67445">
        <property type="protein sequence ID" value="GAE67445"/>
        <property type="gene ID" value="JCM18909_506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14291" checksum="356C0C0ED739B1A6" modified="2014-03-19" version="1">MGAVTTCPEHLSEVVTEHTGGYGAELVIVAIGRNELAEESLDLAAPGGRVSWFAGFPKESTTTITPNTVHYQELTISGGSNASRADVHRAVDMLGRGNIDETPIVTHTFGLSQWAEAVDAVRGHAGVKIAIDPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEZ7</accession>
    <name>W4TEZ7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67361">
        <property type="protein sequence ID" value="GAE67361"/>
        <property type="gene ID" value="JCM18909_411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="36"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="36842" checksum="C4810694843AA284" modified="2014-03-19" version="1">MRCRRPHVRVGLDCGVPIRDGPYGPQKRPRQEGLGMRTAEIGQRFVDFFESKGHTVVPSASLLYNDPTLLFVNAGMVPFKPYLMGTEPSPWKRATSIQKCVRTLDIDEVGKTTRHGTFFQMLGNFSFGDYFKNEAIQYAWELVTKPAEQGGLGFDPASIWVTVLGPGFHPDYPEGDIEAREAWRASGIPDEQIQGRSLKDNYWHMGVPGPGGPCSEIYIDRGPAYGPTVAQKQMRTVTLRSGTSYSRLRISQRCALKMTSTSQAHCAALTSTLVPVSNVLPTYSRASTICTRLTRYSLSLRKRPRCRASGTALATTTTSDYASLLTTSVPVSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF73</accession>
    <name>W4TF73_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67078">
        <property type="protein sequence ID" value="GAE67078"/>
        <property type="gene ID" value="JCM18909_113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7002" checksum="12E844DFD96935A5" modified="2014-03-19" version="1">MDDSEVAKLVFEGVLALVDLIGELAAGLVVDSGASLVDALLDLIAVLAGLILDVVLVVADGVLGLSKSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF89</accession>
    <name>W4TF89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67635">
        <property type="protein sequence ID" value="GAE67635"/>
        <property type="gene ID" value="JCM18909_708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16454" checksum="A473A14EE8493BCB" modified="2014-03-19" version="1">MTATDITVQSGRPRSVANPPADVFRGHKENGSIGITFDDEIIRFHLDRSALFDFVPGVNSSGVGDMAGIGDFKVSVTFPGTVLSHSGSSKVDGDTVTWTDVKDLLSPDGLTASGKSQGGLPGWVWGIGALVMLAIGGAVAAMIINRRWWVRPRDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW4</accession>
    <name>W4TFW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_54</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67024">
        <property type="protein sequence ID" value="GAE67024"/>
        <property type="gene ID" value="JCM18909_54"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021491">
        <property type="entry name" value="DUF3145"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11343">
        <property type="entry name" value="DUF3145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5757" checksum="2F58FE7314A03E6D" modified="2014-03-19" version="1">MRLRSAITAARRTGLRLDDEICDLLGEPWDVELEPYRACDPSLQVPWLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY1</accession>
    <name>W4TFY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67880">
        <property type="protein sequence ID" value="GAE67880"/>
        <property type="gene ID" value="JCM18909_972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="5137" checksum="920D51143DF94EC5" modified="2014-03-19" version="1">MELKESGAELVEVFLRRYWKRTVLGVTLMVTQSFLYNAIFFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG17</accession>
    <name>W4TG17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DinG family ATP-dependent helicase YoaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67084">
        <property type="protein sequence ID" value="GAE67084"/>
        <property type="gene ID" value="JCM18909_119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5522" checksum="2448969943DE20A5" modified="2014-03-19" version="1">MVTNHAMLAIDALNGGRVLPEHDTVIIDEAHELVNRFTRPLRRTSLQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG75</accession>
    <name>W4TG75_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein Q1 colocalized with Q</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67154">
        <property type="protein sequence ID" value="GAE67154"/>
        <property type="gene ID" value="JCM18909_195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021555">
        <property type="entry name" value="DUF3000"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11452">
        <property type="entry name" value="DUF3000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21206" checksum="C8A5E936B95A3A5B" modified="2014-03-19" version="1">MIRQMYPVVFFDELRSRILGYSWSDKLEVHEIPAPTRISPFSVAIEGSVAIRGDELGSGRLILLHDPSGSEAWQGTSRFVAMIRADVDPSMASDPLVGRVAWSWLTDSLESHHAVYHAEAGTVTSVMSRPFGQLAADPESNHIELRASWTPAFSTAEDIDSHLGSWSDLCLLSCGVSPIPDDIAAISPRRAEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD5</accession>
    <name>W4TGD5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_258</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67214">
        <property type="protein sequence ID" value="GAE67214"/>
        <property type="gene ID" value="JCM18909_258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="39"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="207"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="318"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="495"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE67214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="578" mass="63183" checksum="C93C58582ED23A88" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE2</accession>
    <name>W4TGE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68025">
        <property type="protein sequence ID" value="GAE68025"/>
        <property type="gene ID" value="JCM18909_1131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5776" checksum="895DA1E22C8039ED" modified="2014-03-19" version="1">MEGDDLARVVDVMKDLRYVEARRYVDVDTPFFTGERVSPVLWADRQMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI6</accession>
    <name>W4TGI6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68070">
        <property type="protein sequence ID" value="GAE68070"/>
        <property type="gene ID" value="JCM18909_1182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011638">
        <property type="entry name" value="PTS_EIIBC_GUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004702">
        <property type="entry name" value="PTS_sorb_EIIBC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39427">
        <property type="entry name" value="PTHR39427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07663">
        <property type="entry name" value="EIIBC-GUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIIBC-GUT_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6679" checksum="153F292CDF846F9D" modified="2014-03-19" version="1">MALPALFAINTQNACDFIPVGLGLAEAAPETVEVGVPSVLYSRFLNGVPRVAIAWLCSIGLYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP9</accession>
    <name>W4TGP9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="2">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67931">
        <property type="protein sequence ID" value="GAE67931"/>
        <property type="gene ID" value="JCM18909_1032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="7">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24365" checksum="0DDEFFF15D260B40" modified="2014-03-19" version="1">MRRVDVDAHDPDGPEAAARTARRAALLDVAGDEPVLLGHTRDDQAEQVLLSLARGSGATSLAGIRPRSGQFWHPLLEVRRAQTVQACREWEVEPWQDPHNGDPRFLRSRVRTELMPVMEEVLGPEVAASLARSATLLAGEDEVVARVARMWADEHGVNANELPGLRGVEVGLARRVVKEWLPQARMVHVDAVLGLLDGPGGAGVDVPGGRIEISQGTLYLARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGQ5</accession>
    <name>W4TGQ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal recognition particle, subunit Ffh SRP54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68150">
        <property type="protein sequence ID" value="GAE68150"/>
        <property type="gene ID" value="JCM18909_1269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9147" checksum="A331C2A133AB9888" modified="2014-03-19" version="1">MAKRASKQSKKKQKNRKGSGNPAKRAAQARQAAKKPQRSSGEAFGLQGQQQPSQEDLQKAMSEFKMLPSMQQMFNQTNKRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT9</accession>
    <name>W4TGT9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67976">
        <property type="protein sequence ID" value="GAE67976"/>
        <property type="gene ID" value="JCM18909_1079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009323">
        <property type="entry name" value="DUF979"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06166">
        <property type="entry name" value="DUF979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="209" mass="21899" checksum="DE6430BD798223BC" modified="2014-03-19" version="1">MRNVSFDGSPLLETGMATIIGLGAASVIALVAAMIMFKVRSPMMAFKEGDRLLGHIGWAAILPQFLATLGTLFNNAGVGDAVGRITSRILPSESLFAAVCVYCLGMALFTLIMGNAFAAFPVMTAAVGWPLLIQHFHGNMAAVFAMGMLAGFCGTLCTPMAANFNLVPAALLELDDSYGPIKAQIPTAVPLLVCTILIMYLCCFSGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU8</accession>
    <name>W4TGU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67757">
        <property type="protein sequence ID" value="GAE67757"/>
        <property type="gene ID" value="JCM18909_838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10223" checksum="BC64570F6D0986D5" modified="2014-03-19" version="1">MQRALGTIPADRTAVIIAHRLSTVEIADWVLVLEHSQIQENGSPAELEAQGGRYVGLHKPGRSHLPDGDVSEAYPESRSGIEYRPRHHHVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH58</accession>
    <name>W4TH58_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67862">
        <property type="protein sequence ID" value="GAE67862"/>
        <property type="gene ID" value="JCM18909_953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="40"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="14528" checksum="5860D891A533B91A" modified="2014-03-19" version="1">MDKIINIMLGMVVGLLVISVIIAIVGVANTLGLSVVERTREIGLLRALGLTRAQVRSMFGKEALMLSGIAAILGIALGIGYGIAGSHALFFGSLMTVQTSVPWLQLLIVALVAVLAGWLASVIPGRRGAKIKPAVALAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH61</accession>
    <name>W4TH61_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydropyrimidine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68305">
        <property type="protein sequence ID" value="GAE68305"/>
        <property type="gene ID" value="JCM18909_1433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5422" checksum="AF501AD29090850D" modified="2014-03-19" version="1">MSDLHTKYMGLTLRSPLVASAGPIQQKVDGVKALADAGVGAIVMYSLFEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH62</accession>
    <name>W4TH62_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67464">
        <property type="protein sequence ID" value="GAE67464"/>
        <property type="gene ID" value="JCM18909_526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5616" checksum="12698E4D3196C65C" modified="2014-03-19" version="1">MVLALRIVFLDQTNPVAVMTGKKIGCGRLSYLQYAAWGLLVCWSWRERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA5</accession>
    <name>W4THA5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67519">
        <property type="protein sequence ID" value="GAE67519"/>
        <property type="gene ID" value="JCM18909_583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9102" checksum="37F246C961D8BD81" modified="2014-03-19" version="1">MADHSSRTSIPQFCSDQITVSQVRATLDQWYPPSLAESWDAPGLVCGDPDDTVKRIVCALEATDTVVDAAIEPTPICSSFTILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF6</accession>
    <name>W4THF6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67927">
        <property type="protein sequence ID" value="GAE67927"/>
        <property type="gene ID" value="JCM18909_1028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11314" checksum="3CFEBEE1AFD5CF1A" modified="2014-03-19" version="1">MPNAVHDTMSPMSETLVLLAPAANHVYAGQAGRLCTAELSLTCPNATSVAPVTVAGIEYLSIHSEVPSRQQIWRRWRDPRRLWPVSNTAAICWLPSSCRKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK0</accession>
    <name>W4THK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68276">
        <property type="protein sequence ID" value="GAE68276"/>
        <property type="gene ID" value="JCM18909_1400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9111" checksum="3A92536B1DE39F3A" modified="2014-03-19" version="1">MAEALQTAAAGLTKAGTSVGVLTGGRLPVETCLSWSRFARVVLGTNNVDFRSRPHSAEEPPIWLPGSPGTASRNRSPTPTLRRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN3</accession>
    <name>W4THN3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67923">
        <property type="protein sequence ID" value="GAE67923"/>
        <property type="gene ID" value="JCM18909_1023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8280" checksum="90927B8840CDF7BB" modified="2014-03-19" version="1">MADKLPDGDTLCSSSVGAVSTTSCPFALEVANAIPAGAQGDYEVQAYSPVTGKTYTMKCETQESYTTCTGGIAAKVHILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP3</accession>
    <name>W4THP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68455">
        <property type="protein sequence ID" value="GAE68455"/>
        <property type="gene ID" value="JCM18909_1594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19273" checksum="7B329CE387654CC7" modified="2014-03-19" version="1">MPSTLSPDGVSVDDTNPSHTAVATIFWSVSASCALHGFSAIVSGMALAPGLAERFLMVDRSAEIQRILAEVRTRLTDRETLAEVEPLIGSVEEYVPAQDWSQVLLRDHIVVNFISDFLDRVEPHLDPQLRPRGGSFGPWLGRSTGNRVRWDAAMRQVLAAHQDKSGDSLFCSAACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS7</accession>
    <name>W4THS7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Agmatine/putrescine antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68341">
        <property type="protein sequence ID" value="GAE68341"/>
        <property type="gene ID" value="JCM18909_1470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7470" checksum="A41DE59951DBA7D8" modified="2014-03-19" version="1">MGMPHDFSKAQGVSYASFEALTLGTLAFIIVMALIGYWRGAPLRRSGISTESLNQPSTEVHRREPTCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT6</accession>
    <name>W4THT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase 2 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67983">
        <property type="protein sequence ID" value="GAE67983"/>
        <property type="gene ID" value="JCM18909_1086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="187" mass="19571" checksum="D6394C6CDE393D35" modified="2014-03-19" version="1">MSIAMPATGLRSYFSVTGGINASPTFASVSADPTRGMGPAPLKAGDRVSVGDGPAGLISTTPVDIQQAPTELVLHGVWGPRDDWFTDAGRRSLEQTPWRVAQASDRVGTRLEGPSLERAVTGELTSEPVMRGAIQVPTSGVPLVFGPDHPTTGGYPVIGVVDPEDADRLAQARAGVVVRFAMTAHDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX7</accession>
    <name>W4THX7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68545">
        <property type="protein sequence ID" value="GAE68545"/>
        <property type="gene ID" value="JCM18909_1691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase_C" evidence="1">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17359" checksum="E3438765ECEE93B5" modified="2014-03-19" version="1">MEHTDRPAGLVLSRQDLPTIDRSEYASAEGVAKGAYVVCEASADPKVILIGTGSELSVALEAREKLEADGIPTRVVSMPCQEWFDEQDEEYRESVLPSSVTARVSVEAGIAMGWAKYVAARAPRCPLSTSALRPLGHCCSRSSDSPLTTLRRSLTPCCDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY9</accession>
    <name>W4THY9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="6" type="ORF">JCM18909_1150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68043">
        <property type="protein sequence ID" value="GAE68043"/>
        <property type="gene ID" value="JCM18909_1150"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="159"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="263" mass="26071" checksum="B85D87E13C260F23" modified="2014-03-19" version="1">MSGKIAVLGCGTMAGALVGGLIDAGQMKAEDVVATARSASHRDEIANTLGVTTSGDNTTAVRDADLVILGVKHYAAVEVLEEVSGALKADAVVVSIAAGVTTEKLLMAWQGKIVRVMPNTPVRVGKGAFIVSSAPGSEDAATKVGDLLESVGVVVTVPEELHNAATAVSGSGPAYVFLVAEAMIDAAVALGVPRDQASQLTVATLAGSAELLAGGEHPAVLRSKVTSPGGTTAAAVAALEAGGVRSAFADAMTACRDRAAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ5</accession>
    <name>W4THZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68048">
        <property type="protein sequence ID" value="GAE68048"/>
        <property type="gene ID" value="JCM18909_1156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5859" checksum="C25AE808498BC709" modified="2014-03-19" version="1">MVPSIQPYKTPVGLSTSPWRSRWTVVVAPIVSLSDTSRAANPALPMTLRHGAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI05</accession>
    <name>W4TI05_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="5" type="ORF">JCM18909_1276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68157">
        <property type="protein sequence ID" value="GAE68157"/>
        <property type="gene ID" value="JCM18909_1276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="93"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18895" checksum="F3F268BB3013582C" modified="2014-03-19" version="1">MEVVVGRVGRAHGLRGDVVVEVRTDEPDARFGVGATLQVEGSRRDLTVVRSRWAKGSLIVAFDEVKDRQGAEELRGSVLVVDVESNDDPDDPDEFWDRRLRGLTVLMNQVKSRGAVKDVLHMPAQDVLVIDVSGEEHLVPFVHQLVPTVDVASGRIVVSGIPGLLDSNAEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI29</accession>
    <name>W4TI29_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TmRNA-binding protein SmpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68406">
        <property type="protein sequence ID" value="GAE68406"/>
        <property type="gene ID" value="JCM18909_1541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9534" checksum="2ECCED2A9ADC00D7" modified="2014-03-19" version="1">MMRKRKLLLNKREIAKLSREADGPGKTIVPLQLYFKDGYAKVEIAVGTGKRDWDKRQAIRERDAKREAQRALANRVRNRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI36</accession>
    <name>W4TI36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68197">
        <property type="protein sequence ID" value="GAE68197"/>
        <property type="gene ID" value="JCM18909_1319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="16790" checksum="3DEF99727B3CF3D8" modified="2014-03-19" version="1">MIADLVRNDLSRVCQPGTVEVPRLMAIESYATVHQMVTTVRGRLHEDVGLVDVLRATFPGGSMTGAPKERSVEILDDLEVGARGIYSGILGYLGFDHTADLSIVIRTMVRTGSRVTVGAGGAIVAASQPDEEWREKNLKAAAPLAALTEAVHDVPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI45</accession>
    <name>W4TI45_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67834">
        <property type="protein sequence ID" value="GAE67834"/>
        <property type="gene ID" value="JCM18909_921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20969" checksum="E307D713640D5AA9" modified="2014-03-19" version="1">MSQTFGAWRATYTPGSWVVLAGPSSLVVMQPAAPRHSDLVSSIWRHVAEARDPETLVETLSVIGLAKMPSLGVFFWVDGEMYSLARGQIVVKDASTGEVVNHGDGLLTWSEKKLNPATVVVEMERAGQGLSMPLLLGVAQASKLIIDATGNVEPFVVPQTDEVHPHACWLTMRSIRGHQSWTRLTRLTSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC3</accession>
    <name>W4TIC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lipoprotein signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1862</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68710">
        <property type="protein sequence ID" value="GAE68710"/>
        <property type="gene ID" value="JCM18909_1862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10647" checksum="29768EBB0E7AD955" modified="2014-03-19" version="1">MLISLFFAIAMLIAVCVWGVPRARHRWSLIACGMLIAGICGNLTDRIFRAPGPLRGHVVDFMSLPHFAVFNVADIFITSTAILVVVVAVFGHHEDDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE0</accession>
    <name>W4TIE0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68730">
        <property type="protein sequence ID" value="GAE68730"/>
        <property type="gene ID" value="JCM18909_1884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15088" checksum="18D2E01EBF6D1352" modified="2014-03-19" version="1">MVRDWQTDVMELVAGEGMNKRSKARFMAFGVNGVSVALMLVVFAHTGGLSGAEAGIAGGSAIVAQRLLEALFGDDAVRRLAKAAKNQLDARVEGLLANEVTRYRAVLDSSGVDTELPGRIRARSRRSDRLKMRQSLSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF6</accession>
    <name>W4TIF6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68218">
        <property type="protein sequence ID" value="GAE68218"/>
        <property type="gene ID" value="JCM18909_1340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8310" checksum="E18BC2B6E778E2DC" modified="2014-03-19" version="1">MLYVHGWSDCFYQAHLAEVVESWGYDFLGLDLRRYGRNLVPGQMAGWFVTWPNTMRKLTPRCHCCGPITTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH7</accession>
    <name>W4TIH7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67919">
        <property type="protein sequence ID" value="GAE67919"/>
        <property type="gene ID" value="JCM18909_1017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11920" checksum="39E8A383BF23E474" modified="2014-03-19" version="1">MTLDQRHVAGIVVRAVGLALLAGILLALEWAWRTHAWNDLKAVDGRCVLVGARVDDGRVPTVGCHENGARYVKDVVKPSSQCPKGLTRVSVRHELSHDTGYVGALCVRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH9</accession>
    <name>W4TIH9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68775">
        <property type="protein sequence ID" value="GAE68775"/>
        <property type="gene ID" value="JCM18909_1932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="5">
        <location>
            <begin position="36"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="6">
        <location>
            <begin position="98"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="6">
        <location>
            <begin position="215"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="299" mass="33404" checksum="2A2D5879F718FEB7" modified="2014-03-19" version="1">MDACQKKYRDDSRIGGTISFPEAAAIAAQYLTRHSSLADHVLVDEGQDLTPTHWRFIRSLVPEGPNDIFIAEDSHQRIYGHRLVLSRYGIMTRGRSRRLTLNYRTTAQILRWSTHVLEGGFYVDLDGDDDDKLSGYRSARRGPDVIAHPCTTITEEFDYLAKVIGQWAKDRQSETTAVLVRDRSQRERVVDALHERGVQTRAVGHGSIPPGAPVVMTMHRAKGIEFSKVFLFGVSSRSIPMGIKDYDFDKDEGDQALLRERSLLYVAASRARDELVVSWTDQPSPLLNASASSGAASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII9</accession>
    <name>W4TII9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68352">
        <property type="protein sequence ID" value="GAE68352"/>
        <property type="gene ID" value="JCM18909_1481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15419" checksum="E8FF18011AF99BBE" modified="2014-03-19" version="1">MLAKLVTRHLRTYRLHVSVIIVMQVCAQIAALTLPTINADIINKGVVTANTGYVTTHSLLMLAVALGQTICQVIAVYLAAQVAMGMGRDIRDAVFTRTLDFSAQEINKFGAPSLITRTTNDVQQVQMLVFMTLAMLIGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIM9</accession>
    <name>W4TIM9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67984">
        <property type="protein sequence ID" value="GAE67984"/>
        <property type="gene ID" value="JCM18909_1087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14357" checksum="15816F39B3A679D7" modified="2014-03-19" version="1">MSPEQSSVAHVEHLARDRDGHVVTEEQAWSALWALLIGFFMILVDTSIVTTALPATIRALNANLNQGVWITSAYLLTYAVPLLITGRMGDRWGPHRMYIIGMLVFGVSSLACGLSPTIGVLIAARAVQGIGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ6</accession>
    <name>W4TIQ6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">JCM18909_2010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68845">
        <property type="protein sequence ID" value="GAE68845"/>
        <property type="gene ID" value="JCM18909_2010"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="17"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="49"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="284" mass="30630" checksum="551CA7C5A2D1066A" modified="2014-03-19" version="1">MTEPDFDVADSPIGIFDSGFGGLTVARSVVDLMPNEDIVYLGDTDRAPYGEKTIADVRRYALQCLDRLVAHGVKALLIACNTASSAVLRDARERYDVPVIDVIMPAARRASAATRNGRIGVICTEATARSLSYEDALAAVPGITLTTQACPKFVPFVEDGITSGPELETIAREYLAPIQEAGCDTLILGCTHYPLLAGLISYVLGDGVTLISSSHQCARASYSLMAESGLLHSHPRESSRYFLTTGNAERFERLGRRLMEGFVHDVQSVHADAHSLGDRAVVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ9</accession>
    <name>W4TIQ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemoprotein HemQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68024">
        <property type="protein sequence ID" value="GAE68024"/>
        <property type="gene ID" value="JCM18909_1130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010644">
        <property type="entry name" value="ChdC/CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06778">
        <property type="entry name" value="Chlor_dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="225" mass="24687" checksum="6CF8D01704EE8CF6" modified="2014-03-19" version="1">MSDHSSADSVIEGPRDDEVPAGSYTAPTDPRDTPVIPEEVNASSKWAMYSVFRVATALPTEDDERRRLVEGSDEWAGHSGVDTRGWYDLSGLRANADLLVWWVSDDPAVLQDAYHRFRASGLGRHLEPVWSNVGVHRPAEFNKSHLPHASPASPRGVGLRSTPSFAPRSGTSFRRLIVPACCANTASSARPAPTSRRRRWRHSRSGTTSGFSPWKVTTSPVLLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS0</accession>
    <name>W4TIS0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68686">
        <property type="protein sequence ID" value="GAE68686"/>
        <property type="gene ID" value="JCM18909_1837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="104"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="265" mass="27729" checksum="6545D8CF0FD4D11E" modified="2014-03-19" version="1">MASFDSCRANDNGPAITGITLDSRQVRPGDLYVGLHGLHAHGASFAASAVESGAVAVLTDEDGATLAAEAGVPIIVVDDPRVAMAVAAAKIFGHPSDAMTMFGITGTNGKTTTAFLVEAGLRAAGHHVGTIGTIGFRLDGEELPSARTTVTTPEAPDLQGLFAAMAERGASDVVMEVSSHALALQRVDGTCFDVVAFTNLGRDHLDFHNTLDNYFNAKARLFTPDLARVGVINVDDPRGRQLVERMQANGVKAVTTSIHQPLTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ06</accession>
    <name>W4TJ06_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="7" type="ORF">JCM18909_1263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68144">
        <property type="protein sequence ID" value="GAE68144"/>
        <property type="gene ID" value="JCM18909_1263"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="257"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="311" mass="32682" checksum="75733279529878BF" modified="2014-03-19" version="1">MPGSRMARLRRRLANSNNALARGLAELLSADKLDDDAWDDFETTLITSDLGVGPTTELVEKLRSELAIDGISDPAHAREVLHHELVELVGSDMDRSINLDRPEGKPAVVLMVGVNGTGKTTTCGKLARVLVAEGKTVLLGAADTFRAAAGEQLETWGERVGVRTVRKDAGADPASVAYEAVQAGIDEGVDVVLVDTAGRLHTKAGLMDELGKVKRVIEKLAPVSEVLLVLDATTGQNGLTQARVFSEVVDVTGIVLSKLDGSAKGGIVVQVQRELGVPVKLIGLGEGADDLAPFDADNFVTGLMGDDSAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ39</accession>
    <name>W4TJ39_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gamma-glutamyl phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68557">
        <property type="protein sequence ID" value="GAE68557"/>
        <property type="gene ID" value="JCM18909_1704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5635" checksum="213749E7A48EF4DC" modified="2014-03-19" version="1">MNCSSRFVDGGEFGFGAEIGISTQKLHARGPMGLREMTTTTYVLRGDGQTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ46</accession>
    <name>W4TJ46_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68418">
        <property type="protein sequence ID" value="GAE68418"/>
        <property type="gene ID" value="JCM18909_1554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="14994" checksum="4A7B221B137B6CCE" modified="2014-03-19" version="1">MERERRTETALLARTRCELDESYRNLPSFKPSVPEGIRTPLPDIPNKRPTTGVGLCGLSALVSGPIGPAVGFALTAQGSWAHSKIKLQLVTQIVFFAFVAGFGIGPMGFGLNHRNAGFLSLIWTVVTIVQAVRGFKGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ58</accession>
    <name>W4TJ58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrofolate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68577">
        <property type="protein sequence ID" value="GAE68577"/>
        <property type="gene ID" value="JCM18909_1724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_C" evidence="2">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="188" mass="19888" checksum="225226E93AB32343" modified="2014-03-19" version="1">MQAPARLEVVRRSPLVILDTFHNPHGAASAMAGVRESFEVEPLIAVVAAMADKDVDGVLAVLSDTVSYLVVTSMPDLPRALSVDELADKASAHWDSDHLTRVTDVPEALEEAFRIADSCGPGAGVLIAGSVVLAGRARAILRPDGTMLDAPQTAIVETPDLSEDQVKAMEGHQLEPLPDDDMSDDGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ65</accession>
    <name>W4TJ65_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68831">
        <property type="protein sequence ID" value="GAE68831"/>
        <property type="gene ID" value="JCM18909_1995"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="286" mass="32437" checksum="64D72F69ECC23628" modified="2014-03-19" version="1">MQPPLPEPAVCAPRDHPEYADLDVHERSQARSARAQAAADVEAIDRDRSWNAKLPVLEAVHALGLEGSRELSYQAFRRLRGTRLGDLATWCALTEVYGNDWRTWPEEYQRPSNRAVSEFVRAHEERVDFFMWLQWIADQQLSAAQSAGRDAGMSLGLMCDMAVGVSGAGADAWMLGKLFADGVCVGSPPDAFNQAGQEWGQPPMRPDILADLAYRPFRDMVRAALRHAGGIRIDHILGLFRLWWVPVGLGPRMGTYIRYDHEAWLVFWRWRRTGLAPLSWARIWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB0</accession>
    <name>W4TJB0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Respiratory nitrate reductase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69035">
        <property type="protein sequence ID" value="GAE69035"/>
        <property type="gene ID" value="JCM18909_2216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molydop_binding" evidence="3">
        <location>
            <begin position="238"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="384" mass="42466" checksum="D275F7DEB2751011" modified="2014-03-19" version="1">MHDTPDEMTTPAGSVSREQEAWIPGVTMPKLVTVERDYTQIGAKFDTLGPLTESLGMVTKGVPFHPDPEVADLARRHGVATSGPGAGRPLLDTAIKACDTILATSGTTNGRLATAGFEQLEARTGTKLTDLSVGSQDRRVTFTDTVIQPQPVITSPEWSGSEHGGRRYSAFVINMERHKPWHTLTGRMHYYLDHDWMRDMGESLPIFRPPLDVAHIYDEPPAGYTGTDADGAAVVSVRYMTPHNKWGIHSQYYDNLHMLTLARGGQTIWMSPADAAKIGVSDNDWVEAYNRNGTVDARAIVSHRIPEGTVFMYHGQERTVNTPLTERSGKRGGTHNSLTRILLKPSHFIGGYAQLSYAFNYYGPTGNQRDEVTLIRRRGQEVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD0</accession>
    <name>W4TJD0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68891">
        <property type="protein sequence ID" value="GAE68891"/>
        <property type="gene ID" value="JCM18909_2063"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6868" checksum="357BFC698184C19F" modified="2014-03-19" version="1">MLCPTVAHCRAVASHGADVLAVHRDPDTAAKLNRIPGVMAVCGSPESLPLNSSSFDAVLVHQAFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH0</accession>
    <name>W4TJH0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmA</name>
        <name evidence="7" type="ORF">JCM18909_1715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TJH0"/>
    <dbReference type="EnsemblBacteria" id="GAE68568">
        <property type="protein sequence ID" value="GAE68568"/>
        <property type="gene ID" value="JCM18909_1715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9523" checksum="07071F18E6FCB5C2" modified="2014-03-19" version="1">MAHKKGASSSRNGRDSNAQRLGVKRFGGQLVNAGEIIVRQRGTHFHPGDGVGRGGDDTLFALRDGNVEFGTRRGRRVVNVTPVEAPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI1</accession>
    <name>W4TJI1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68921">
        <property type="protein sequence ID" value="GAE68921"/>
        <property type="gene ID" value="JCM18909_2096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="269" mass="28826" checksum="9AA796E767CB7C12" modified="2014-03-19" version="1">MLIATDLDGTLLTPDGTISPRTRDAIRVAEKAGVPVVPVTARQIYGIEKWRDDLGRWALCSNGAICWDLQARTVLFRQLMPGAVANEFAHRLLDAAPGTRFLTIKDDGLTFASQRGYAELTTFADHSREPSDMPALDLDEVLDGDCLKMVARHPNLPVEELAARAASVGMAGEVHVTTSGKPMLEISAKGVAKDSGLSMLCDHLGIEQRGTVAFGDGANDVEMLAWAGDSYAMAHAVPLAVAAARHRAPSNAEDGVAQVIEKLLAMRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ4</accession>
    <name>W4TJJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68593">
        <property type="protein sequence ID" value="GAE68593"/>
        <property type="gene ID" value="JCM18909_1740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="14868" checksum="E9CB6049CB56D5D5" modified="2014-03-19" version="1">MTRIGERWRLYSMTTEVVDVLARNVSKTWRKVTFSVVVPYRQEWVTEPIKKIWHRRPSSRRRFSILSFSAVKIYFNLPEIKHMSLINTTFRGGFGMRLGCIVTPFMMQRGKILFARRLRKKTAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK0</accession>
    <name>W4TJK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68941">
        <property type="protein sequence ID" value="GAE68941"/>
        <property type="gene ID" value="JCM18909_2116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="231" mass="24737" checksum="A9E9F3186E8662C2" modified="2014-03-19" version="1">MLGMVGIMAIGLAACGDKTNSSSDTPANPSPSTKAVKRISKDDFTKAFSHKKIDGHTFVIQDNSQLRPVVDNLDKTLSQAKISPAGCDAALRQSSLGLTSHEISDTLVAVSDKPSTRIIVTTAMSDRQKKAYKSQEEQTSKCGHTTLSTQGVNHGLEINIKASPIKGYENISKQAALFDVSIKRSTGTSDHGYQAYIWLNNDQAIRIFGRDAGIVKSTLQSATKALGIAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP9</accession>
    <name>W4TJP9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68653">
        <property type="protein sequence ID" value="GAE68653"/>
        <property type="gene ID" value="JCM18909_1803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="29534" checksum="9D2741C619F071CC" modified="2014-03-19" version="1">MSALVHDDLMDHSDTRRGLPSVHRRFEAAHGIAHGDGPAEQFGCDIAILLGDLLLMWSSQMFTSAPVKADRLAAATPLLDAMRTEVTCGQVLDVTSQSGMAGSDSESALDLVGRVVEYKCASYTVVRPCQIGVALAGGSDRLQQTMADFGSPIGRAFQYRDDLLGVFGDAELTGKPAGDDLREGKRTVLVAHALNRADSYDAARLKSLLGRPDLDDDDVATARRIIETSGAREAVESTIVQCHDHAVAVLDDAEMTDAGQIALRELARQCVERHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ3</accession>
    <name>W4TJZ3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gmad1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68434">
        <property type="protein sequence ID" value="GAE68434"/>
        <property type="gene ID" value="JCM18909_1572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gmad1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="230" mass="24245" checksum="60F8267E3BB9749F" modified="2014-03-19" version="1">MISPRSPGAVWHAVSADRRSLLTWQEGSEDIQVLATGVNLRRPQVLGDHSIMTFSDTDPTLIVVGSDGTRMSTVVDLGGRRVTSFSVAPDAVRVALVLERGKTRALGIGLLSRQEGAVHLSHIADIPLSSSDVNLSIITDVAWLSQTRLCVLGRAIDAGVTAPYEIVVDGSGATSMGQLTATSMAAVVALPTETGTEAVVLSEDGILLHHEDSFRWRQILQGVSAVAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK26</accession>
    <name>W4TK26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69151">
        <property type="protein sequence ID" value="GAE69151"/>
        <property type="gene ID" value="JCM18909_2340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="oligo_HPY" evidence="4">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10211" checksum="48723D263D47B498" modified="2014-03-19" version="1">MHPYTQGLLSAIPVPDPAREHDRHRILLEGGLPSPAAPPSGCPFHTRCPKFKGFDEASQAKCVGERPELHYPQPDVDRRTACHFPEEIRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK77</accession>
    <name>W4TK77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68907">
        <property type="protein sequence ID" value="GAE68907"/>
        <property type="gene ID" value="JCM18909_2079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9607" checksum="15AD5D19C6D54DD5" modified="2014-03-19" version="1">MDPVLPVVTEMIDAVNNGAIGEPTGIQGDLFALRDYDPDDRLFSPALGGGVTLDLGVYASVSPFASLESPPRSSPVATTSPMRWIPTLRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK78</accession>
    <name>W4TK78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68838">
        <property type="protein sequence ID" value="GAE68838"/>
        <property type="gene ID" value="JCM18909_2003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6446" checksum="30AFA0A93E9F5581" modified="2014-03-19" version="1">MRRSILPSAYRDDDSADAQFHVDHDAEDVAARWEDAQSLSADVETLHRTGCISMNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL0</accession>
    <name>W4TKL0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69331">
        <property type="protein sequence ID" value="GAE69331"/>
        <property type="gene ID" value="JCM18909_2535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="268" mass="29037" checksum="DDE6F9A1E4F94B8A" modified="2014-03-19" version="1">MLAWARRRPWLAGILMGLACAGSLQAAVVAFAVLVCCLRATRLPELGRYLLAGSLVLVVCHVIAVCLGLHTWWAYLRSTFWSGTGLGTIWYVIQDSSGGIIPGIGWITGTLTVGGLLGLAWLSMTVPRRPRIAQVACVALLILFITNKAYSPQWILFLVPLAALARPDLRDWAVLMVGECFYSLAVWAHLGGLSLPGGSDADVVYWASVVLRLACEMWFAWGVLDDIRRPWNDVVRVGYADDPTGGVLDHAPDPAPEPVEDSSAEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM1</accession>
    <name>W4TKM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69077">
        <property type="protein sequence ID" value="GAE69077"/>
        <property type="gene ID" value="JCM18909_2261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="3">
        <location>
            <begin position="26"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="230" mass="24683" checksum="9ED280AF5D6D2EE4" modified="2014-03-19" version="1">MKAALVEQYHEPLAIRDIPEPAHDSDGVVVEVKACGVCRSDWHGWQGEWPGFTGGSLPHIFGHEFVGLVSDIGSNVSRYRVGDRVIVPFTLGCGHCEYCRSGHSNVCPTVSMPGFSYDGGFAQYVAVPDADANLVKLPDSVDFTDAAGMGCRLMTAYHGVVEVGRIHPVTGLSSMVQAAWACRPPSSLPAQGQTSSPSTSQMTSLPWLARSGPSRPSIRAKPTRWRQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM5</accession>
    <name>W4TKM5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine--tRNA ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68963">
        <property type="protein sequence ID" value="GAE68963"/>
        <property type="gene ID" value="JCM18909_2140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="10">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="242" mass="26424" checksum="9C806DF7F94F110D" modified="2014-03-19" version="1">MRFPHHENELAQSAAAGRPFAHYWMHNAWVTMSGEKMSKSLGNTAQVTEVTKTYSPRAVRYFLLAPHYRSMIEFSPSDEGTKGSLDEATKAIERIDSFLDRASNLVGEQVTASHELPEAFVTAMDDDLGTPQAVAALFSQITEGNKSVSIGDAEATRHHLSQVKAMLAVFGLDPQAPEWADTATGDARLEPVVDGLVQAMLDQRAEARARKDWATADAIRDTLTNLGLTIEDTPTGAHWSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN6</accession>
    <name>W4TKN6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69351">
        <property type="protein sequence ID" value="GAE69351"/>
        <property type="gene ID" value="JCM18909_2558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9296" checksum="8DBBFD7DF163CF58" modified="2014-03-19" version="1">MEMEGRSVHGTPEGYEAMMVRSAHLEQAGWRILHTTPTMLRRDPKFVLDWIINHLHKRHRPKTTLTNQVLRQIMNGAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR6</accession>
    <name>W4TKR6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69376">
        <property type="protein sequence ID" value="GAE69376"/>
        <property type="gene ID" value="JCM18909_2585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="237" mass="25962" checksum="CAB982DCC70D5094" modified="2014-03-19" version="1">MDLRAFVYLPLRLPFVSVTDGTLTPMATGYLRYPDVHGDLVVFTADDDVWLVPVTGGRASRLTNDHVMVRNPRFSPNGTKIAWMSYLGQRPEVFVIDLVTGDQRRLTWLGAARNLVVGWQDDEHVVFSSPHQTNDVGLAWLYTVSLDGHVERLGYGPGMDLAVSSDGAVAVVTPNSGDCSRWKRYRGGTAAQIWLRPAGAEKFLRLLREGNDNHDGYAAAGRYSVAGSTVVSSSVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY0</accession>
    <name>W4TKY0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin-6x reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69615">
        <property type="protein sequence ID" value="GAE69615"/>
        <property type="gene ID" value="JCM18909_2853"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27042" checksum="37BF99676C856E6F" modified="2014-03-19" version="1">MDVLILGGTTKARQLATRLIDEGVDLCSSLAGRTKSPRPVPGPTRVGGFGGVDGLKEFLTDNEVKVMVDASHPFAAAMHGHAAQACRDLNLPLARLAPPSWRTQPEAATWHWVDDHDGATQVLTDLPDVILLTVGRQPVSHYLRLGPRRVIVRCVDAPEEELPAGWTVLRERGPFTLDREREIFSQGVATLVSKDSGGTGLDPKLRLAAETDVQVVMVSRGPAPGWGDELNTVDDAVQWTSDHIATVIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL41</accession>
    <name>W4TL41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lead, cadmium, zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2448</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69252">
        <property type="protein sequence ID" value="GAE69252"/>
        <property type="gene ID" value="JCM18909_2448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="4665" checksum="F2833465D1C372CC" modified="2014-03-19" version="1">MGIVIKGAGSLERARGIDVMAMDKTGTLTTGRMAVVAVWDGSGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL52</accession>
    <name>W4TL52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-ribulose-5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69700">
        <property type="protein sequence ID" value="GAE69700"/>
        <property type="gene ID" value="JCM18909_2949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5500" checksum="896DD410046F5C2C" modified="2014-03-19" version="1">MLEKLKTDVCRGNLELPRHGLVTWTSGNLSVRDLRPALSSSSRPGCCMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL64</accession>
    <name>W4TL64_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69272">
        <property type="protein sequence ID" value="GAE69272"/>
        <property type="gene ID" value="JCM18909_2472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6942" checksum="714F9861A6713111" modified="2014-03-19" version="1">MWAIQAQASDRRSRKKSHLGSRSIISMILLYSRRRFFALLHRLGPHPGGDARIARVTREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL88</accession>
    <name>W4TL88_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69745">
        <property type="protein sequence ID" value="GAE69745"/>
        <property type="gene ID" value="JCM18909_2994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849298" evidence="2">
        <location>
            <begin position="32"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19040" checksum="FA3D30C7FE3767D2" modified="2014-03-19" version="1">MSGKALIARRTALGGLLVATGAAIGVPVVRAANRPQKQAPRKPVPTTVTSPAAPGPYVPFPYQDELSTYLNTRDGEQSVAMRVHGQREIQVFNHGATTYITASIIKLAIMETVMIQAVGEKRQLTEGEKDLLVPMIENSSNDAATALWKKVGKADGSARRCVVWEPPTLPSILRAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL91</accession>
    <name>W4TL91_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytosine/purine/uracil/thiamine/allantoin permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69297">
        <property type="protein sequence ID" value="GAE69297"/>
        <property type="gene ID" value="JCM18909_2497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PTHR31806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18071" checksum="E02980C14C9AA21E" modified="2014-03-19" version="1">MSAPNSAQGEVRHGNPAPTISGAGRGVEKRTIDMVPDSERHGTPKSQFTLWFGVNMQITAVVNGALAVVFGANVVWVLVGLFIGQIIGGAVMALHSAQGPALGLPQMISSRAQFGVYGAALPLFLVLLLYFGFAATGTVLAGQAINNACGVQSRWIGILVFCSSDGNYCHVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC4</accession>
    <name>W4TLC4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68949">
        <property type="protein sequence ID" value="GAE68949"/>
        <property type="gene ID" value="JCM18909_2126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="65"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17503" checksum="5A87703520737F22" modified="2014-03-19" version="1">MGYVHYDQFWFLETSEGPGDIRHRFSTTDRRARTCPWKGTTVMATVQYKEATRVYPGTDRAAVSKLDLDIGDGEFMVLVGPSGCGKSTSLRMLAGLEEVNAGSIWIGDRDVTDLPPKDRDIAMVFQNYALYPHMTVADNMGFALKMQNVPKLNASSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ1</accession>
    <name>W4TLJ1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GalBD_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69382">
        <property type="protein sequence ID" value="GAE69382"/>
        <property type="gene ID" value="JCM18909_2591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040502">
        <property type="entry name" value="GalBD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17974">
        <property type="entry name" value="GalBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GalBD_like" evidence="1">
        <location>
            <begin position="157"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="388" mass="42019" checksum="82B2CEF674E2B9A7" modified="2014-03-19" version="1">MPAAKTPNWGEGSHFVNPGFYSGDTAGWNARGNVSVKHNDRGNFHLEFGKAQSQISQVLNLPAGDHSLWAWVQIDPTKTRPVGLAVDGTGVTPIDHQKGCGGHAESVITSTTAINATASDEYFGTYHQRLRVAFHSDGRPVTVTLKALAGNAVVSADDFRVVDAAVPNDPHITPATVLFQNFEDVDTGYWPFVTGSAGMEGDARTQLSRRHEPYTQKGWNGRAMDSVLSGDWSLKMHEERNGIVLRTTTASAPLTGDGTRYRVSFDYQADKPGYSFVTGHDKVNGKSVKEVITESHAMGVATSTTHFSTDIVVKDQPAWIGFTHQGEGDMSIDNLRIEKLDPRPASATSTQAAVFPDACKPAPRTDPTGATLGFRSDDIRLLPSLWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK8</accession>
    <name>W4TLK8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ctaB</name>
        <name evidence="9" type="ORF">JCM18909_2606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69397">
        <property type="protein sequence ID" value="GAE69397"/>
        <property type="gene ID" value="JCM18909_2606"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="377" mass="41935" checksum="09D10D423175FB22" modified="2014-03-19" version="1">MPFSISKDTVSNQTTHVATAPASQRPDPVETKLEQEQGRPRLSSRDVVHAYVALTKPRIIELLLVTTQPVMFLASHGVPKLGLAIATMVGGLFAAASANVFNCVIDVDIDQKMRRTRRRPLPRHQVPRRNALIYGIILGIIATIILGFGANWLSAGLALIANLFYVFVYSMLLKRRTWQNTIWGGIAGCFPPLIGWTAVAGSVGWEPLVLFFIVFWWTPPHTWALSFRYREDYEAAGVPMLPVVRDAPEVAVQILIYAVMTVATTLVLWPVAHMGWIYVVVAVVSGAVFIVEAAQLLRRANAGLRDALLKPMGLFHWSNTYLSLLFFWLSRLIRSFICDDRNSGVIGGFPRSPVSYPFGLTVTASKVRQHHMQRSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLQ8</accession>
    <name>W4TLQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron(III) dicitrate transport system permease protein FecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69363">
        <property type="protein sequence ID" value="GAE69363"/>
        <property type="gene ID" value="JCM18909_2571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="23001" checksum="CD35136E3A22292F" modified="2014-03-19" version="1">MIMVAAALGAAVVLLIVMLAGRFIHSSTILLLLGVMIGYFVSSGVTVLLSRASPELIAQYTRWQFGSYHGVTWQNLRVMVSIIVAMILASLLLAKPLNALLLGERYAQTMGMNLKVVRTLLVASTAILAGAATAFCGPINFLGIAIPHLTRGVLGTADHRHLLPGCILTGSSLALMADILAQLPGDDVLPVNAVNAVFGAPVVMVILIRWYREAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU0</accession>
    <name>W4TLU0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69388">
        <property type="protein sequence ID" value="GAE69388"/>
        <property type="gene ID" value="JCM18909_2597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="9"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="378" mass="42643" checksum="B1621B35643FCA42" modified="2014-03-19" version="1">MLRLIAHPDDERYQHLFGTTVTTPLYGVEVPVLAHSAAEMDKGAGIAMCCTFGDLTDVAWWRELQLPTRTIIGRDGRILSETPQWIIDAGSAERYEAIAGKTTFTARKLVVEALVESGEMDGEPKPTQRKANFYEKGDKPLEIIGTRQWYIRNGGRDDDLRNALLERGRELEWVPEHMRHRYENWVEGLNGDWLISRQRFFGVPFPVWYPLGADGEPDYDHPLLPDESALPVDPASQPPSGYQESQRGVAGGFIGDPDVMDTWATSSLTPQIVTGWERDADLFAKTFPMDFAPEAHDIIRTWVFSRVVRAHLENGVLPWKRAAISGFVTDPDRKKRCQSRRAIPSSRPKSLISSVPTRCAGVPLWPVQAWIPLSTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX6</accession>
    <name>W4TLX6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69751">
        <property type="protein sequence ID" value="GAE69751"/>
        <property type="gene ID" value="JCM18909_3002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9185" checksum="592001D37C951730" modified="2014-03-19" version="1">MRIAVLDTGPCESSLGGKRFQGLTAIASTGGSVGERAVIASLIVVWGATRLSSSRVDGLGRGFQRICEVLGRRAEQAGSRRRRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM61</accession>
    <name>W4TM61_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2382 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69279">
        <property type="protein sequence ID" value="GAE69279"/>
        <property type="gene ID" value="JCM18909_2479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019060">
        <property type="entry name" value="DUF2382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09557">
        <property type="entry name" value="DUF2382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2382" evidence="1">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5559" checksum="60C712298A684311" modified="2014-03-19" version="1">MTHEERPVVNKETVGVEKIKIGKEAVQDTETVSGKVAKEQIDIDNAKHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC6</accession>
    <name>W4TMC6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69687">
        <property type="protein sequence ID" value="GAE69687"/>
        <property type="gene ID" value="JCM18909_2936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HsdM_N" evidence="3">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="17011" checksum="71D1EAC1C9471A9D" modified="2014-03-19" version="1">MVPTTKEMQRSELHKTIWRIANDLRGSVDGWDFKTYVLGMMFYRFISENLTDYINEGEWRAGDTDFNYCNLSNADARDIFEEMVAEKGFFIFPSDLFVNVRARAAQDENLNETLEGVFRNIEGSAAGTPSERDLKGLFLRTWTSTAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG6</accession>
    <name>W4TMG6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69732">
        <property type="protein sequence ID" value="GAE69732"/>
        <property type="gene ID" value="JCM18909_2981"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="6002" checksum="0389F7C9C74C24D1" modified="2014-03-19" version="1">MPRSVDHVEKVSDASTSHGIRTAWDLMVIPRSRSISMRSKYWARALRSSRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK5</accession>
    <name>W4TMK5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69777">
        <property type="protein sequence ID" value="GAE69777"/>
        <property type="gene ID" value="JCM18909_3029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5249" checksum="DC4213ECE1301F24" modified="2014-03-19" version="1">MLEPSSCQDALSEAFAVEEDEDEAGSDFVEDSEAVGEELSPVAAFDAPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ0</accession>
    <name>W4TMQ0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="3">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3262</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69986">
        <property type="protein sequence ID" value="GAE69986"/>
        <property type="gene ID" value="JCM18909_3262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="6">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="E1_dh" evidence="7">
        <location>
            <begin position="324"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="689" mass="76803" checksum="2BAD8D8AF991B25C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ3</accession>
    <name>W4TMQ3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70265">
        <property type="protein sequence ID" value="GAE70265"/>
        <property type="gene ID" value="JCM18909_3569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="197"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="257"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="476" mass="51411" checksum="C4E2771A5C466615" modified="2014-03-19" version="1">MIRRWWRRLLDWRPRPLRMTMGRRVSLLVSTSVVVAVALTSLSAWLMTRISLYSELDEQLTRMAATISPSVAADPQNLGGLEASSLAATNTTLILVRADGQVTTAPGAEVTVTTGPQELAVARTGIGVKAHTVIDSRGVPVRIVAVPFTSDGVHYALVTGQDLTGTRATLGSLWIVLVGTGFVGIVLTAIAGYVAGNSATSPLRDLSRAVHHVTTTEDLTPIQVHSHDELGDLAVSFNNMLSSLSNSRERQKQLIADASHELRTPLTSMRTNVELLMADQKSHMLPEEARREILDDVAAQLGEFSSLIGDLVQLSREDAPPPRPEYFDLSYAVSKAVERGRRRGPNLEFDVHLEPHLVLGDEATLERAVTNLLDNAVKFSPAGGTVTVTMEGNTVIVSDEGPGIAEADLPHIFDRFYRSDRARNTPGTGLGLSIVAHTVTSHQGWIKASRAPSGGAMFTMYLPRAEPPVEEPTVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN25</accession>
    <name>W4TN25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69917">
        <property type="protein sequence ID" value="GAE69917"/>
        <property type="gene ID" value="JCM18909_3184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8764" checksum="A949BBC6909D4051" modified="2014-03-19" version="1">MQTVVDDYRKVVGRRAVIAHQDKIVHPSSSTATSEVGRFESVQLTGQSGGWRPGGQTFVSLLDGEVAAGAPDTGANRPRWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN46</accession>
    <name>W4TN46_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Octaprenyl-diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69629">
        <property type="protein sequence ID" value="GAE69629"/>
        <property type="gene ID" value="JCM18909_2869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="22940" checksum="04E9B9E2581DCF02" modified="2014-03-19" version="1">MAIMVGDYLFSRASLAVAELGVDFVKLQARTFSRLVQGQIAETRGPSQGQDPLAHYLKVVADKTGSLIAASAVFGAMVSHASAENVAALEQFGEDIGEVFQLADDLIDITSTVTGKTPGTDLREKVPTLPTLLLRASDDPADAELKEMLDADLSDDAVLSDVLDKLRANHVIDEARVEIQRRADRARTHLTPLPDGDAKQALEALCDEVVSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND9</accession>
    <name>W4TND9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70256">
        <property type="protein sequence ID" value="GAE70256"/>
        <property type="gene ID" value="JCM18909_3559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="262" mass="28104" checksum="BD69C53662C855A1" modified="2014-03-19" version="1">MSTAPRPPTCQKPPPRDTAVFFSSFQYFTLVGGLVTAQAVLLLLSSLMSEATIHAWGWRIPFFIGGVAALIVFFMQKTMDESLSTEHLKSVRSGEDSSSGSLKELFGNHLGNFLLAFTIASGGTLCFYVYTVNAPNIVHSTFSSTPMAATAVNLIVLFILMLGQPLGGLIGDRIGRKPVLLFFAAGGVVYTWVLVTCLSHVRKPVTAFLMLLMGYIFLTGYTSISAVVKSDLFPTDVRALGVGMAHGFANSLFGGTAPLIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH8</accession>
    <name>W4TNH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70515">
        <property type="protein sequence ID" value="GAE70515"/>
        <property type="gene ID" value="JCM18909_3848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="2">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="253" mass="25991" checksum="7A2DAD6C44881196" modified="2014-03-19" version="1">MIVTVTLNPSIDRTAPIAGPLRRGQVNRLGSSTEVAAGKGVNISRVLRGAGIETCAVVPAGAKGRLALGLNHDDIPHLVVPVAAAVRTNLTITEPDGTTTKINEPGADLSPEELTAIEEAIVEQSSGAQWVVLSGSLPPGVPTHWYATMTDRLHEVGVKVAVDTSDQPLQELAARSPTVPLTSSSRTPSNSANYAGLTATPSSLLPQGDSSTTLSRPPEVCTASPKSSSPWAGPALCSSPSTMPGTPGQSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI9</accession>
    <name>W4TNI9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70107">
        <property type="protein sequence ID" value="GAE70107"/>
        <property type="gene ID" value="JCM18909_3398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10353" checksum="44C9BB0C369A9EC3" modified="2014-03-19" version="1">MIIEAVRSGPHSIDELAKLTGASSVSVRRDLAELADQGVIRRFRGGAARYLIVGLTIPSPCAKPQALSPNPLWPRPRPSSSNRERASSSTTAPLHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNQ8</accession>
    <name>W4TNQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69844">
        <property type="protein sequence ID" value="GAE69844"/>
        <property type="gene ID" value="JCM18909_3102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022508">
        <property type="entry name" value="ABC_trspt_anch-rpt_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03771">
        <property type="entry name" value="anch_rpt_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="252" mass="27040" checksum="3F3D1B39D5AC2B6F" modified="2014-03-19" version="1">MNDLGSIKITDVAVNVGGLQVLHDVNISASKGDLLALLGPNGTGKTTILRTMLGLVKPAKGTVEVAGASPGKGWRHIGYVPQRHEFAWDFPISVADVVMSGRTRHIGWLRRPRRGDHIAVRDALRTAGMAELANRTVGELSGGQRQRVLIARALATRPSVLLLDKPFTGVDMPTQEQLTELFIELSEAGTTLIMPTHDLAQAMATADRVCLVNRTVIADSTPQQLRDPAMWMQTFGISGSSPLLRIVGADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR4</accession>
    <name>W4TNR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5'-nucleotidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69849">
        <property type="protein sequence ID" value="GAE69849"/>
        <property type="gene ID" value="JCM18909_3108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13682" checksum="7CF66D5B9106E84F" modified="2014-03-19" version="1">MLGDFNAYAMEDPIRAMKASGFSEVVEEHDPDAASYEFSGRVGSLDHIFANAKVHELVSGAGIWDINGSESVAMQYSRRNDNVTDFYTTSPFGASDHSPAWWASRCRLRPPAQYRRLPRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP44</accession>
    <name>W4TP44_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70183">
        <property type="protein sequence ID" value="GAE70183"/>
        <property type="gene ID" value="JCM18909_3480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9760" checksum="0FC003C11F414DA4" modified="2014-03-19" version="1">MRILHISIDDINAARERTVPAGSTRARLLALHKAGCDIAEIATMLDVTMSYAANLMSGEEQMCTEMTRLRSRAACEARGLLSTAESMASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP59</accession>
    <name>W4TP59_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="6">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_3255</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69979">
        <property type="protein sequence ID" value="GAE69979"/>
        <property type="gene ID" value="JCM18909_3255"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="29"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="10">
        <location>
            <begin position="192"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE69979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="29552" checksum="14B4329ED0AB8AC7" modified="2014-03-19" version="1">MIMSQQNRVFGVIETYRDRLPMDGIDQIVTLGEGATPLVPAPRLGAELDATVWIKVEGANPTGSFKDRGMTMAMTKALADGSKAVVCASTGNTSASASAYASRAGMTPVVLLPQGKIAAGKLAQAVVHGGRIIQVLGNFDDCLRIARELAENFPVSLVNSINPYRIEGQKTAAFEVVDVLGDAPDIHALPVGNAGNITAYWKGYREYVADGPASHTPRMFGFQAAGAAPLVLGHDVNDPETVATAIRIGRPASGKLALAARDESEGLIDAVTDEQILDAQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPD1</accession>
    <name>W4TPD1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-threonine 3-dehydrogenase</fullName>
            <shortName evidence="6">TDH</shortName>
            <ecNumber evidence="6">1.1.1.103</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tdh</name>
        <name evidence="8" type="ORF">JCM18909_3699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonine + NAD(+) = (2S)-2-amino-3-oxobutanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:13161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78948"/>
            <dbReference type="EC" id="1.1.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.103" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70382">
        <property type="protein sequence ID" value="GAE70382"/>
        <property type="gene ID" value="JCM18909_3699"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00046">
        <property type="reaction ID" value="UER00505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019518">
        <property type="term" value="P:L-threonine catabolic process to glycine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00627">
        <property type="entry name" value="Thr_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004627">
        <property type="entry name" value="L-Threonine_3-DHase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="7">
        <location>
            <begin position="12"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="263"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="287"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom" evidence="6">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="345" mass="37280" checksum="216719272B1ECF95" modified="2014-03-19" version="1">MKALVKTRPEPGLELVEVPDPVAGPNDVIVKVMRTGICGTDVHIDKWDGWAAKTVHTPLVLGHEFCGEIVELGSEVNDLEVGQFVSGEGHYVCGRCRACLAGKRHLCRNTQGIGYAVDGAYCQYFVMPAGNVWVHHIPDLAPDVAAIFDPFGNAVHTALQFPCLAEDVLVSGAGPIGIMAALVAQFQGARNVVVTDLSDERLELAQQLGLENAVNVSREGLETVWDRFDMKEGFDIGLEMSGSGAALTSMIDNMTHGGRIALLGTPSNDITLDFSKIIFNMITIQGVTGRQIFETWYTMASLIRSGLDISGIITDRYPITEFREAFDVAGSGHGGKVVMNWECLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPL3</accession>
    <name>W4TPL3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70353">
        <property type="protein sequence ID" value="GAE70353"/>
        <property type="gene ID" value="JCM18909_3667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="20438" checksum="F3E58144EDAF113D" modified="2014-03-19" version="1">MVEDALTALILGNKGGTVTEDSAVWLDDHQQRVWRLWLEVSTTLPAVLNRQLSRDSQLSVQDFEVLVRLSETDGGEMRVVALAEHMGWERSRLSHHLTRMEKRGLIERRVCCSDGRGAIIHLTDQARRHYNRPPRATLLWSDASFFDGLNCGHLNDLEAILSRICQSLAEEDKVNPTDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPP0</accession>
    <name>W4TPP0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III delta prime subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000073">
        <property type="protein sequence ID" value="GAE70706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70706">
        <property type="protein sequence ID" value="GAE70706"/>
        <property type="gene ID" value="JCM18909_4089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9695" checksum="E38104FF942FCEE6" modified="2014-03-19" version="1">MLKAIEEPAPKTVWLLCAPTPEDVIVTIRSRCRRLHLATPRDEAVADLLTRRDGVAPEVAAEVPALVKAYRAGAAPGLGRGGSCATQRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPR7</accession>
    <name>W4TPR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70517">
        <property type="protein sequence ID" value="GAE70517"/>
        <property type="gene ID" value="JCM18909_3850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6350" checksum="EA3246073AABAF37" modified="2014-03-19" version="1">MKIVIFFSAGGNSLRAVQLLTAIGKQFGVRVPLRNFYSNPTISCLVSLLMPVEEREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPS0</accession>
    <name>W4TPS0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phenylalanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70224">
        <property type="protein sequence ID" value="GAE70224"/>
        <property type="gene ID" value="JCM18909_3522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="4">
        <location>
            <begin position="42"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="363" mass="38705" checksum="895313B0E0DFDC07" modified="2014-03-19" version="1">MKVPMSWLQAMVNLPDGTTTDKVAKALTNHTATVEKVEVVGGELTGPIVIGHILSSVPEPQKNGKVINWCRVDVGPRYNAEGHPKNIEEGVEGRGIICGAPNAVEGAWVVVSLPGAVLPGGFAISARKTYGHMSDGMLCASDELGIGVDDAGIITLPPSVEGHQLVPGEDALPILGVPEEVLDVDVTPDIGYCMSMRGIVREVAHAMSVHFRDPYDEEPIGPVRGPVDVDVQSDACSQFIALPVSGMNPGAPTPRFITDRITRAGMRPINLVVDVTNYVMLESGQPLHAYDADNVSGTIVVRKAYEGEHLLTLDDTDRTLDPDDLVIADDSGALAWPASWVVWSPKCLLGRRQSSSRALTSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPV9</accession>
    <name>W4TPV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low molecular weight protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70269">
        <property type="protein sequence ID" value="GAE70269"/>
        <property type="gene ID" value="JCM18909_3573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="2">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="15800" checksum="61199EDD474895FA" modified="2014-03-19" version="1">MDARITSAGVSDEEHGDPMDSRARSVLKSHGYPCSGHNAHQIDESEIMSADLVIAAEPRHIQMMKRMAPDATTSVSSATTTPNAPLAPPCRTPGMARPTGSRTPSTPSRPQCPESLTRCAHWPDQFPAMALVPRDQSLRHYRLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPZ6</accession>
    <name>W4TPZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70453">
        <property type="protein sequence ID" value="GAE70453"/>
        <property type="gene ID" value="JCM18909_3780"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5987" checksum="2C9EA8107128190F" modified="2014-03-19" version="1">MALLCQVYDQYAGETGGSLAQIAAVTEIVERDLRSSTLVEEREGSRFRWHSAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDP6</accession>
    <name>W4TDP6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA-i(6)A37 methylthiotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67075">
        <property type="protein sequence ID" value="GAE67075"/>
        <property type="gene ID" value="JCM18909_110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="14071" checksum="38A9ACCBFC354AB3" modified="2014-03-19" version="1">MCAMPNNTLQYTEAPTYRVVTYGCQMNVHDSERIAGLLEEAGYVPDPRTDTLASADVVVFNTCAVRENADNRLYGTLGHMAAVKSAHPGMQLAVGGCMAQKDKDTVVARAPWVDVVFWHPQRWLAAGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE22</accession>
    <name>W4TE22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_51</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67021">
        <property type="protein sequence ID" value="GAE67021"/>
        <property type="gene ID" value="JCM18909_51"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16471" checksum="D0F29A6610EAD90F" modified="2014-03-19" version="1">MSVADNLAAVRTRIDDACRACDRNPGEVSLLPVSKTKPPSMVDEAYRAGYRLFGENKVQDALAKSELMDANHPGLEWSIIGGLQTNKAKYVARFATEFQALDSLKIAHELDKRLQKEGRQLRVLVQVNSSAEPQKTWDSSRGSCRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEP0</accession>
    <name>W4TEP0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67261">
        <property type="protein sequence ID" value="GAE67261"/>
        <property type="gene ID" value="JCM18909_307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="301" mass="33506" checksum="45B50730D3067A7C" modified="2014-03-19" version="1">MDHRGATGADPAAGGDGAGILVQVPDAFLRRTTGIRLPEPGSYAVGLAFMPVDEAQRACARAAIELIAADEGIKVLGWREVPVHTHTLSEISLGTMPHFEHLLIRARDGRVGMDLERLAFVLRRRAQHEAGVYFASLSSRTFVYKGMLTTHQLEEVFPELHDTDLSSAVALVHSRFSTNTFPSWELAHPYRLIAHNGEINTVRGNRSWMQAREALLQSDLIPGDLARLYPICTPSGSDSASFDEVLELLHLGGRSLPHTVLMMIPEAWQENTEMSQELRDFYEFHSFLMEPWDGPACVIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF24</accession>
    <name>W4TF24_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic hydroperoxide resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67386">
        <property type="protein sequence ID" value="GAE67386"/>
        <property type="gene ID" value="JCM18909_442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="PTHR33797"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15062" checksum="748EA1F1510A8155" modified="2014-03-19" version="1">MIEIEPVYTTEAIATGAGRNGHVQSPDGRVSEDLAIPVEMGGSGKGTNPEQLFAAGYAACFHSALQMVARQAKKGPWRLLGGCAGFNRSGRGGVWPCRRPGGRHPALPHDEAQQLADKAHQVCPYSNATRGNIRVDVTVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFA1</accession>
    <name>W4TFA1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67207">
        <property type="protein sequence ID" value="GAE67207"/>
        <property type="gene ID" value="JCM18909_251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17003" checksum="AE903A1B7DEC058F" modified="2014-03-19" version="1">MPPSDNIDKTGSTTVTLTINDAPVVLTVDRAMAPCAANAFISLAEQGYYNDTSCHKLSTGDAKYLQCGDPSGTGNGGPGYSYPVERGAKAGGSVGSGTLALVADSQHRLGSQFALVYGDSKLSDSFLVIGSIDKDGAESISDIAHKGLADDGLTPKVDTKIGSVVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFD6</accession>
    <name>W4TFD6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Riboflavin synthase eubacterial/eukaryotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67680">
        <property type="protein sequence ID" value="GAE67680"/>
        <property type="gene ID" value="JCM18909_758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5856" checksum="6426786274A29DA5" modified="2014-03-19" version="1">MTVCAVASEWFEVSLIPATLTGTVLGALSPGDEVNVEVDIIAKYLEALTNKERSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW7</accession>
    <name>W4TFW7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67865">
        <property type="protein sequence ID" value="GAE67865"/>
        <property type="gene ID" value="JCM18909_956"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6671" checksum="13BFF0EAD7BDD53C" modified="2014-03-19" version="1">MPTLSAADNITLPLRLSHTKVDKEWFDHITGMLGITERLGHKRRRCLADSSSASPSPAPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG61</accession>
    <name>W4TG61_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67139">
        <property type="protein sequence ID" value="GAE67139"/>
        <property type="gene ID" value="JCM18909_179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016499">
        <property type="entry name" value="NucleicA-bd_Rv2694c_prd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006910">
        <property type="entry name" value="NA_bind_Rv2694c_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14469" checksum="9DAADC95C26C268E" modified="2014-03-19" version="1">MVRGTDTRAHRESTLRRVLHRVTASNEALADDDLQRSSLDAGASTIAGAKLRTRASLQGRIEVLTLNPRGSNRWLEAELRDGTGAVTLIWMGRRRIPGLRAGRHVNVEGMITEADGRRVIYNPRYTILPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG97</accession>
    <name>W4TG97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67816">
        <property type="protein sequence ID" value="GAE67816"/>
        <property type="gene ID" value="JCM18909_901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850731" evidence="1">
        <location>
            <begin position="27"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="436" mass="46068" checksum="DECB2DC891EE16C2" modified="2014-03-19" version="1">MNRTLKAAAVGALAALCLTACSDPGSDSSQSSGPESWPSATTNLNGVELTMWAAQSSASIPQQVAANFNKATGAKIKIVTIPDPYEQSVQTKVATGDVPDLAMWQPTTSMLTSLGAKEHLQVLDDAPWESKTDKNVLAAGGSLDGHRYAAFVSAPSVMGVWYNKEIFAKNGIQVPKNFDEMLTIAKKLKAAGQTPFYEMGGEWWASQWAVQVQLADAAKAGLWDKVNKDEDKFTGAEIQGAINTYDTMIKDGLFNSDIATGTFNDQAKALLDGKAAMTIQVTSLLGNMAARADTATLNTKIGFFPISKSGTVATSIPDQTNAVVAFKSKDAKRETAARQFITYWLSNDYASFIKAQNTVSIIDGVKTPDSVPKALIDSNATLKGSVGSMQSLAVANPDLAKNLGDMIAGTKTPAQVGSETQSQFAQLAKAIGAKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB1</accession>
    <name>W4TGB1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67826">
        <property type="protein sequence ID" value="GAE67826"/>
        <property type="gene ID" value="JCM18909_912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="240" mass="26103" checksum="A50FF309C8A35839" modified="2014-03-19" version="1">MLAWQADDKPVIWFDAEHADESEAVIRGGIPLCAPWFGHGPNNDQDPQHGLARRTDFEVTVADPFRVVGVAETASIGIRHEVVMTNTALEMTLTLTNHDQKPRVVEGMWHTYLRVADAAQARVRGVRGASWHNFATGDKGSFDANELAVAPDTDTVIQGVGPALALLDPAWGRQIHVETTGRPSAVVWNPRSSSTHADNPTAQAWRDFVCVETGACKDNAVIVAPHSDLIMSTRISVETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD6</accession>
    <name>W4TGD6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67473">
        <property type="protein sequence ID" value="GAE67473"/>
        <property type="gene ID" value="JCM18909_535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021465">
        <property type="entry name" value="DUF3117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11314">
        <property type="entry name" value="DUF3117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5885" checksum="CD70C0B6E4489510" modified="2014-03-19" version="1">MAAMKPRTGDGPMEVTKEGRGIIMRVPVEGGGRLVVELNADEARELLACFKDVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF0</accession>
    <name>W4TGF0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67488">
        <property type="protein sequence ID" value="GAE67488"/>
        <property type="gene ID" value="JCM18909_550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7774" checksum="8751999C1A61FE2C" modified="2014-03-19" version="1">MCVSDEPGIYFKQTDLLVPEEFRGTGVRIEDDLCITDGEPEWLSKDCPRQVDEVEAWMQEIWGRACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH4</accession>
    <name>W4TGH4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate-ammonia-ligase adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67513">
        <property type="protein sequence ID" value="GAE67513"/>
        <property type="gene ID" value="JCM18909_577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22272" checksum="22BFFB18F365F8F7" modified="2014-03-19" version="1">MDRKSSVTIDLLRLGVMDTDAASANHHRIAENIGADPNRLAGWEHHLETCCDPDLALNVLAELAQDSAQCLGELLDHDASACRLVRLLGASSELGRHLIAHPDDLAEVIRDPVRLGHDEIRDDLLEVVGAHKEGEFMVAGAPTGPASDRLRLANRRHLVRIASRDVSADDPTEIIEDVAAELADLADGIVTAALALARAGCLIMPMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK1</accession>
    <name>W4TGK1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67662">
        <property type="protein sequence ID" value="GAE67662"/>
        <property type="gene ID" value="JCM18909_737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="13"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="23570" checksum="23546B6561F5244B" modified="2014-03-19" version="1">MNDYLRPIYLQSIWETLFMALITLVMGGICGLVLGILLYATRRGGLLANKIVHTILNVIVNIIRPIPFIIFMTAIAPLTLKVIGTTIGVRAATFPLCIAATFAISRIVEQNLVTVDPGVIEAARAMGAGPWRILFDVVAREALGPLILGYTYILIAIVDMTAIAGALGGGGLGQFAITYGYQRYNWEVTAVAVVTIIIVVQLAQFLGNWLARRALRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM3</accession>
    <name>W4TGM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68115">
        <property type="protein sequence ID" value="GAE68115"/>
        <property type="gene ID" value="JCM18909_1231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15474" checksum="0FE096787057019A" modified="2014-03-19" version="1">MINEENPITEVPEDSCWGYLDTAEVGRLATSVNDQPEVFPVNYVVDGQSIVFRTAAGSKLEDIVTNNRVAFEADGWTEEAGWSVVLRGKAEIITDDAELALCDKMPLLPWVPTVKRNYVRVEADQITGRTFAFGPEPKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN2</accession>
    <name>W4TGN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67916">
        <property type="protein sequence ID" value="GAE67916"/>
        <property type="gene ID" value="JCM18909_1014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="31"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="23910" checksum="EF373DDD8E50A02E" modified="2014-03-19" version="1">MGSWLLYPTPEGPLVCRCVWGPEEVDLEGKLPTCPGKADGAAVAAAARDRRTRAEILQTVRRTVEDAGVDMEVLAIDLVESGDDRAIAVYFRAPHRVEFATIVGPLARRLHARIDLRQLRGRDTARVVGGVGVCGRSLCCSTFLPEPSSVPNRLVGEQGMASNPLAVTGACGKLMCCLRYESPYYADFEAALGEVRVPDAPRCPLMSTCSRRRDQEHKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGQ6</accession>
    <name>W4TGQ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67941">
        <property type="protein sequence ID" value="GAE67941"/>
        <property type="gene ID" value="JCM18909_1043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18388" checksum="93C1796BC81ADDD3" modified="2014-03-19" version="1">MHMAADFLRVHPQSRVCVVDADVEKGDVAAVLDIRQSVSIADIAKVYSDLSANTVGDAVIQHESGIHVMLAPVDVRESDYITPEAIHAILDLLRMEFPLVIVDAGGHVSPSQAAIAQMADEMVVVTSPDAWSCEPSASGLRPGSPWECVTRRSSRLSSTRSTRGRSSQLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT8</accession>
    <name>W4TGT8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Holliday junction resolvase YggF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67364">
        <property type="protein sequence ID" value="GAE67364"/>
        <property type="gene ID" value="JCM18909_414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="5022" checksum="7A4B7A827D5D75D7" modified="2014-03-19" version="1">MAASDRDAILAFPVETVHTTDRPVQRLAEIVAEYEPVEVIMGLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX9</accession>
    <name>W4TGX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68220">
        <property type="protein sequence ID" value="GAE68220"/>
        <property type="gene ID" value="JCM18909_1342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850726" evidence="2">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="11647" checksum="05E96CCB09B70B4B" modified="2014-03-19" version="1">MYAKKIAALATASMLVLAGCSSTTTSEEGSQGSATSSSTPKAGGAGGEVGVFTWWANGSEAKGLQLSRRCSPKSTRTIGLKNLAVAGGSGSNAKAKLASDLKNGNLRVPSKVTLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ2</accession>
    <name>W4TGZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuraminidase NanP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68235">
        <property type="protein sequence ID" value="GAE68235"/>
        <property type="gene ID" value="JCM18909_1358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12141" checksum="86216E146D4408C9" modified="2014-03-19" version="1">MYDRVTASVMVLVDDHEIAATCWRVMEVAAPLVRYPESGGVYEIDVPGLVPDRLDPLGRFGTRFLPDQWQSLVVELTAPLDPGSHTLDIRFVDDDGSSPTPRNASKWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH70</accession>
    <name>W4TH70_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67872">
        <property type="protein sequence ID" value="GAE67872"/>
        <property type="gene ID" value="JCM18909_963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19858" checksum="3B34B5842C08F854" modified="2014-03-19" version="1">MKPIPGLDELLHRAVEEKHIFGTKERSVILDDDKAGIEKIVDQQFELAEQVRAAGLVPILEPEVDIHAPQKEKAEERLHNLIRAHIDSLPIDAKIMLKLTIPSSEDLYADLIADPKVLRVVALSGGYSREEANKKLARNKGLIASFSRALAEGLNVAQSQQEFDQTLRASIDSSYAASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH82</accession>
    <name>W4TH82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67882">
        <property type="protein sequence ID" value="GAE67882"/>
        <property type="gene ID" value="JCM18909_974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5655" checksum="A2332454004D58DF" modified="2014-03-19" version="1">MIFTTYGIAALVLAISAVLFQRDVLTPTTHTIFWCVAFFFLLVPELPRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH86</accession>
    <name>W4TH86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67793">
        <property type="protein sequence ID" value="GAE67793"/>
        <property type="gene ID" value="JCM18909_877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022789">
        <property type="entry name" value="ParD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038296">
        <property type="entry name" value="ParD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09386">
        <property type="entry name" value="ParD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8552" checksum="676B70D2110416B7" modified="2014-03-19" version="1">MATIQIRNVPEETSRELKARAALQGKSLSEYTLEVLQNTLKNPSREQLMQRIMAQTARTDLPPMVEVLQEGREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH91</accession>
    <name>W4TH91_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68330">
        <property type="protein sequence ID" value="GAE68330"/>
        <property type="gene ID" value="JCM18909_1459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6606" checksum="77CDC3C0FF0E5252" modified="2014-03-19" version="1">MPIFCGSPGRSSAQRAGGWWNWPVADAAGPVSVGWIIATTVCGVLALSLPVRTVRRHCEADLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA8</accession>
    <name>W4THA8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mg(2+) chelatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68171">
        <property type="protein sequence ID" value="GAE68171"/>
        <property type="gene ID" value="JCM18909_1290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mg_chelatase" evidence="1">
        <location>
            <begin position="175"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="25144" checksum="6AB233950F52AB4F" modified="2014-03-19" version="1">MVEVEAAISSGLPRTVLVGLPDAALHEARDRCRAAVCATGLSWPSNVLTINLTPAGLPKAGTHFDLAIAAATLAADGKVPQALLGSTVLIGELGLDGRVRPVRGVLPALLAAREAGFERAVVPASQSDEASLVEGLTIWPVGHLGDVVDVLHGRPVVPSEGPIVGSPDTDPGIGDLAEVIGQHEARRALEVAAAGRHHILLRGAPGCGKSMLHDGYLGFFPDLITVTPSKSPHCIPWPDEGAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE7</accession>
    <name>W4THE7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68216">
        <property type="protein sequence ID" value="GAE68216"/>
        <property type="gene ID" value="JCM18909_1338"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS_C" evidence="10">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11426" checksum="9B84D9345AF4B05E" modified="2014-03-19" version="1">MSHVTGGGLANNLARVLPDDLVATVDRSTWTPAPVFNLVQQVGNVSQPDIEATLNMGVGMVVVMPDANISAAIDLLAERGLSAWQCGHVSHRDATNELGAVLVSSHPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG8</accession>
    <name>W4THG8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68236">
        <property type="protein sequence ID" value="GAE68236"/>
        <property type="gene ID" value="JCM18909_1359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="2">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="383" mass="40080" checksum="48A952FB7893EF91" modified="2014-03-19" version="1">MESWFLMGQGRSDGAEQLGGRSLTDLRDHNQAAVLDCLVTATQPVTIRRLQELTGLTRPTVSAAMNSLLEQGDALEQESMHAGGRGGRRSRMFTLNATKRVQAGAAIRLQGVELGLADWHGEMLASTSRPLRGGSPGALLDEALDDLLQELGLDSVDTMVIGVLGSVGPDGRLRHNESLPEISDPDHFAALHDGRVGHVMIENDAVLAALAEQHVRGLAGTESMVSLLIDASVGAGIILDGRAIRGSAGYAGEMSYLPGSGWATAHLDLVDAAARHDVSAEALFELAGSPHAPVWAEQAVDSFADAIAPGVAALLAALDPGLLVIGGHARPAYVRIARRLRASLRDDLPHLPCIEASRAGAHAVVQGAVELALAQPEASTRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH1</accession>
    <name>W4THH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67883">
        <property type="protein sequence ID" value="GAE67883"/>
        <property type="gene ID" value="JCM18909_975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4333" checksum="8551369369F1815E" modified="2014-03-19" version="1">MLTGDLVALFMGVDAEGKGLEAITDPLSRDRAKKSAARQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH7</accession>
    <name>W4THH7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67614">
        <property type="protein sequence ID" value="GAE67614"/>
        <property type="gene ID" value="JCM18909_687"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="256" mass="27729" checksum="815DDC3C4C4E67C1" modified="2014-03-19" version="1">MLMTYGSSDDRAGNSVAWWAFHNVDDVASIFPLTDGQRRQLQMAGSLRVTTDEQASNAEITVPRDLGWLGQIKVIGHGYTPPAKSSDSSVSRGFLYVGLSPNQEDTAYHWATTHHIDPSYVMAPRMAPKVPLPAATLVATGLFTMMTVIMAGSLARDERLAQRRLTAHLRRLGLTPRWVDGVIFFEVAMTCVVAVIAGTIGSLLALLATSRIMSGTMDLVHSGWWVVAALVGSVMVGSTLGATIHRPYSWNTTISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP2</accession>
    <name>W4THP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68032">
        <property type="protein sequence ID" value="GAE68032"/>
        <property type="gene ID" value="JCM18909_1138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7685" checksum="9A6BC962E3E067CD" modified="2014-03-19" version="1">MIRAAAEAVASQVDPRPAGSSLLPAVENLRASSATVAVVVVHAAIEEGIATKKPSNVVQAVQDAMWWPHYPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP4</accession>
    <name>W4THP4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdh</name>
        <name evidence="13" type="ORF">JCM18909_777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67699">
        <property type="protein sequence ID" value="GAE67699"/>
        <property type="gene ID" value="JCM18909_777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="156"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE67699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="327" mass="34688" checksum="A5D2C500D7A61BFF" modified="2014-03-19" version="1">MTQTPVKIAVTGAAGQICYSLLFRIASGSLLGDTPIELRLLEITPALKALEGVVMELDDCAFGNLVNIEIGDDPKKVFDGVNAAFLVGAMPRKAGMERSDLLTKNGAIFTAQGKALNDVAADDVRVLVTGNPANTNALIAATNAVDIPNDHFAALTRLDHNRAKTQLARKTGKTVNDVRHMTIWGNHSSTQYPDVFHAEVAGQKATNLVDEAWIENEFIPTVAKRGAAIIDARGASSAASAANATVECMRDWMGSTPEGDWVSMAIPSDGSYGVPEGLISSFPVTITNGKVEIVQGLDIDDFSRAKIDASAKELADERDAVKELGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV7</accession>
    <name>W4THV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine phosphatase PPP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68366">
        <property type="protein sequence ID" value="GAE68366"/>
        <property type="gene ID" value="JCM18909_1495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5863" checksum="8EDAA14943E43BC7" modified="2014-03-19" version="1">MRYAPVDSMTRHRRHWLWPVVILAFVAVVVGGIFLALAPTSTPSTTLVPTTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI47</accession>
    <name>W4TI47_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68630">
        <property type="protein sequence ID" value="GAE68630"/>
        <property type="gene ID" value="JCM18909_1778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-oxidase_C" evidence="1">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10087" checksum="82812112099B04B1" modified="2014-03-19" version="1">MIGSEGTLGFISSAVMNTVIMPNLATALLHFPTLDAATKALPALVKSGVTVTELMDSSSLQLCRDDPANGHIIPPAPGSGDAALLVEYHCPDQKITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC1</accession>
    <name>W4TIC1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68178">
        <property type="protein sequence ID" value="GAE68178"/>
        <property type="gene ID" value="JCM18909_1297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12727" checksum="A20745CD1BF79318" modified="2014-03-19" version="1">MATPALANTGTSSQPAAAAPAINQVHKETGYFKTTDKLGTQLFYRKDIVPNAKGAVVLVHGLMENSSNYEYLTKSLTNAGYSVYRFDNRGHGVARPRTSTTLSRAASSTTGGTSSPTSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC5</accession>
    <name>W4TIC5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68183">
        <property type="protein sequence ID" value="GAE68183"/>
        <property type="gene ID" value="JCM18909_1304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5312" checksum="8E277ADC416AB166" modified="2014-03-19" version="1">MQRVRKHRGIAQGTPLLGSALSVSGLARLVNPALLICSTPSSLRAKIFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF9</accession>
    <name>W4TIF9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68561">
        <property type="protein sequence ID" value="GAE68561"/>
        <property type="gene ID" value="JCM18909_1708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="5">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="272" mass="30628" checksum="15EBA23CF17DF6E0" modified="2014-03-19" version="1">MRHIERCRAIVHVIDCATYEPGRDPVSDLDVIEGELIAHGGLEDRPRLVVLNKVDVPDAADLADIVFDDVAERGWPVFRVSTKSGEGLNSLKFAMAELVEKARDSEPEPELERIVIRPEPKNERQAFSIKRQGDGEGGFLWRVTGDKPTRWVAQTDFNNPEAVGYLSDRLNRLGVEEELLAMGAIAGDAVAVGGEDAVIFDFAPQIESGAELLSCRGEDQRLKSERPSATRRREMDREYHRAREEYGQVGRDLRGESWRARVAEEEWFEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII2</accession>
    <name>W4TII2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt-zinc-cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68243">
        <property type="protein sequence ID" value="GAE68243"/>
        <property type="gene ID" value="JCM18909_1366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="222"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="311" mass="33986" checksum="68172F4C22D56178" modified="2014-03-19" version="1">MTTIPDIPAVTSRHRPPEDLSRFAWLSIAAAIATILLKTLAWHITGSVGLLSDAAESLVNLVAAIIALVALKVSIRPPDMNHQFGHSKAEYFSAGAEGMMIFIAAAVIVYSAVERFLYPRPIADAGVGLLVSVLASVINGAVAWVLLRNGHKRRSMTLIADGKHLLTDVWTSLGVLVGVGLVWLTGWQRLDPIVAFAVGINILVTGAKLVRQSGTALLDVSLPEEDNAAIRDFLAAHSNDHLTFHAVRTREAGYRQFLEFHMLVPGSWTVKQGHDVMEDLIDEILEEWPEMRVSGHLEPIEDPRSYEDIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ5</accession>
    <name>W4TIJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67939">
        <property type="protein sequence ID" value="GAE67939"/>
        <property type="gene ID" value="JCM18909_1041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="259" mass="27898" checksum="C39DFA683A9DF47A" modified="2014-03-19" version="1">MLTMSDLFVVAEAHPYWPSPSSWRDDDPFVLVMGVDNPSALAVWVREYDVGGVVIVHRAQTDRQVRFMANLASGAVPGLSVTTVTHRASALAAALACREVAPWREPLASKVEWLERILTTARSGVVLSSVAGLHDPNPGIMRHLASLLPWGPPFVVQFTPGVEFVRLPNSDSLFEGGVGSWHVTEGDGPLPCPFQLASVERPVADVRAEYGGHGREFALLGWPSGDREYVGCCPVCGVQCVSVVCPVCHVHVLVQESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ6</accession>
    <name>W4TIJ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68790">
        <property type="protein sequence ID" value="GAE68790"/>
        <property type="gene ID" value="JCM18909_1953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849259" evidence="1">
        <location>
            <begin position="33"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="13930" checksum="E5AA300AFE8C8864" modified="2014-03-19" version="1">MNARAAVAVTVLLVAAGCAPSHGGAVPSPSAASATPAPAGAETLADLGFKYGPRNFRLPKGLAVTLRVDHVNNITLLIGPDTSGKVHDFLADNLSASGFTVTGNANGSLTFISNRGDTKGWSGGFTSSDEAAGLTLRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP3</accession>
    <name>W4TIP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68298">
        <property type="protein sequence ID" value="GAE68298"/>
        <property type="gene ID" value="JCM18909_1426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15213" checksum="8B9362086AE88950" modified="2014-03-19" version="1">MPQNPENYLVARTAADELFASPMVPEDADLRDLVRTFGLKPILDSHPMTCSGGEKRRLAIAAALAQRPDLLLLDEPTVGLDDDRGASVLSAIRAAADSGVAVVVSSHDRQVIAMADEVVDVASYRVPDPTPNERPGEKNRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP4</accession>
    <name>W4TIP4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68004">
        <property type="protein sequence ID" value="GAE68004"/>
        <property type="gene ID" value="JCM18909_1109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="292" mass="30944" checksum="92E9327726DC72D4" modified="2014-03-19" version="1">MSETVRRVTSEEQIEPEPNVINVVDTGTIPHADSIEWGSVQELAGRAAIASIEAATAAALSGKIDGVVTSPINKEAIWKTGSEFLGHTEMLGSLCGTPDTDTMFVVSGLKIFFATRHMSLREAVDSIRRDLIDHEIHKALRALKVFGCNSPKLAVAALNPHAGEGGHFGTEEIEVLRPAVKSACAEGYNVVGPVPADSVFHKGVIGEYDGVLSLYHDQGHIASKTLDFDGTVSVTAGLPILRTSVDHGTAFDIAGQGAASPMTMQSALHVASDFARFVPAIREEYSPNTGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR1</accession>
    <name>W4TIR1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 4">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 4"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68850">
        <property type="protein sequence ID" value="GAE68850"/>
        <property type="gene ID" value="JCM18909_2015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="6">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20745" checksum="67340E8EB7388DC9" modified="2014-03-19" version="1">MTRIRRYPLQSRSDRVPGSSFHQAAGGSMKVVAIAAVADNGVIGSGQEMLWHISEDFRRFKTVTMGHTLIFGRRTFEQIGKLPGRRHIICTRDPHWFRKGVDVATSPRQAVEMAREAGEEICFVAGGGQIYADAFELCDELDITEVHQNPNGAARFPAIDPEVWVEVRREPRDGFDFVGYRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ3</accession>
    <name>W4TIZ3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">DNA ligase</fullName>
            <ecNumber evidence="6 7">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ligA</name>
        <name evidence="10" type="ORF">JCM18909_1918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="6 7"/>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68761">
        <property type="protein sequence ID" value="GAE68761"/>
        <property type="gene ID" value="JCM18909_1918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 6 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIGANc" evidence="9">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="6">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="563" mass="62109" checksum="6A1AF32ACD909E1E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ38</accession>
    <name>W4TJ38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell envelope-associated transcriptional attenuator LytR-CpsA-Psr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68806">
        <property type="protein sequence ID" value="GAE68806"/>
        <property type="gene ID" value="JCM18909_1969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="2">
        <location>
            <begin position="69"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="306" mass="32927" checksum="B994A002DD401545" modified="2014-03-19" version="1">MLLLAWVVWLVAVPSYALGHTGTVDATPDGPRGADHPGTLVLLVGTDERQNLTPRQQKQLGTGTEAGLRTDTMLLLYMPPEGKDVLISLPRDTFLRIPGHHHNKLNAAYSMGGAKLLVQTIEKATNLRINGYVEIGFGGFVQMVDAVGGVHVTLNKPMVDKDSHTNLPAGPQNLDGVQALGYVRMRKADAEGDLGRVKRQQQVAAQVAKKTLSPWTFINPVRYWKVNMAASKAVKLGTDTSTLTAFKTARGLMKVSGNDGIKTTVPVSTASAYTSAGSSVLWNDKKAAQLWDDLRSGDTSKVTELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB1</accession>
    <name>W4TJB1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68627">
        <property type="protein sequence ID" value="GAE68627"/>
        <property type="gene ID" value="JCM18909_1775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11225" checksum="8E2A9F9AC8B27245" modified="2014-03-19" version="1">MTDRSPRRQEPSTGSTPSNSSTTHTGDSAQSGSPKWRIIALVVVIALIIAAIAVIFIQRNNDSDSAGGAASSTTATTTSSTSGIPAASAAKKRPSSSRLHEKTPSRSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK4</accession>
    <name>W4TJK4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3'-to-5' oligoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68722">
        <property type="protein sequence ID" value="GAE68722"/>
        <property type="gene ID" value="JCM18909_1876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="PTHR11046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22744" checksum="5F71DA4B976F9F93" modified="2014-03-19" version="1">MLVWIDCEMTGLDLAHDGLIEVAALVTDGQLNVQGEGVDVIIKPEPQWLDHMNDFVRDMHTTSGLLAELDKGLTMTQAQDQVLDYIRTYVPQAGKAPLAGNTIGTDRSFLAKDMPKLESYVHYRNVDVSSIKELARRWYPRAFGHSPQKQGNHRALADIQESIEELMYWREVIMVPSPGPETTRCDEIAAKYQGFLTRAGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS3</accession>
    <name>W4TJS3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68384">
        <property type="protein sequence ID" value="GAE68384"/>
        <property type="gene ID" value="JCM18909_1519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="371" mass="39706" checksum="CF2E4582BF05E1BE" modified="2014-03-19" version="1">MTPGFGVQDVGTKDENALVMSTIKSLTETNQVLDESGKAVQLASQRLNEAGSNIGDKTINDLKASSARIDTNAKTTAQTVSQLAEQTSAAYHETGSLISGQLAQTTATMKGLLGDPHSSVAPVSVDASTCKIKAKAEPSGKTPDNAAAHDVLGVIHGLSARLDALAKTSGECQKLATTDLISFLGPTNPDAKTCAASSSGLSCALYAQKEHLSQSIQDLTGQDAQLAAQLRNGSQGKMLASVQQLRLNFGDLQRAVGDLSADSPQAYGESLRKMDVALAVMIHDVTETRAELDQIHTKLQDELSLLDEQDHQITAVMRESVWLPARLFRPVRHRLLARRVLPARLRHRARILLRRHQNQSSAPLIAKRGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU1</accession>
    <name>W4TJU1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribonuclease YcfH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69056">
        <property type="protein sequence ID" value="GAE69056"/>
        <property type="gene ID" value="JCM18909_2238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="10918" checksum="90D741C0D5496F6A" modified="2014-03-19" version="1">MNEAIREVLGEAGAPPLPEPLAGSIVDSHTHLDTVQDVVGIEPAISLAAAREVGVIRIAQIGCDIAGSEFAEELARTHKNVIAAVAIHPNDAARLGRKKRLVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV7</accession>
    <name>W4TJV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic glycerol-3-phosphate dehydrogenase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69240">
        <property type="protein sequence ID" value="GAE69240"/>
        <property type="gene ID" value="JCM18909_2435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046174">
        <property type="term" value="P:polyol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017752">
        <property type="entry name" value="G3P_DH_GlpA_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03377">
        <property type="entry name" value="glycerol3P_GlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="4">
        <location>
            <begin position="4"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="541" mass="59101" checksum="AD213CBB5EF3DC08" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX0</accession>
    <name>W4TJX0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68832">
        <property type="protein sequence ID" value="GAE68832"/>
        <property type="gene ID" value="JCM18909_1996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13783" checksum="B20448D36AFE17A8" modified="2014-03-19" version="1">MRHELGLLTESLEHERAEVARQTATWIAILRERGVLVGDDPSEEDIVLAMHRMLTRTPSKVLNATLTDAVGDRRTQNLPGTTNEYPNWRVPLSHPDGSPMWLEEVFTDERAARLSHVMNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX3</accession>
    <name>W4TJX3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69260">
        <property type="protein sequence ID" value="GAE69260"/>
        <property type="gene ID" value="JCM18909_2456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="209" mass="22383" checksum="63AFD9A134B90AAF" modified="2014-03-19" version="1">MVTGGTSGIGREFVTQLAARGDDIVIVARDTERMAAIKADVEARYGVSVETIAADLSRREDVDQIATRVEDPNHPVDLLVNNAGFAVHAKILDPEALKLHDRALEVMMRAVLVLSAAAGRAMKARGHGAILNLSSSSAWINTGNYSAIKAWVLTFTEGLSNELAGTGVKAMALCPGWVHTEFHSRANVTANHLPDFFLDRRRGPGARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK24</accession>
    <name>W4TK24_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II restriction enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68783">
        <property type="protein sequence ID" value="GAE68783"/>
        <property type="gene ID" value="JCM18909_1941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="513" mass="58200" checksum="67CE1DBAB150DD25" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK42</accession>
    <name>W4TK42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTP-glucose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68494">
        <property type="protein sequence ID" value="GAE68494"/>
        <property type="gene ID" value="JCM18909_1636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13421" checksum="D9DF36D8B92072A5" modified="2014-03-19" version="1">MIAQSNIDPERIRAFALLDSDDSGQLTDIIEKPDSHIVDAAGETALVSMNCFLLTPRIFEACRSIDKSERGEYEIVDAVRWMVEHGEHFDVVPVESGVLDMSNRGDITSVVEALSSREVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK59</accession>
    <name>W4TK59_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="11" type="ORF">JCM18909_2377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69186">
        <property type="protein sequence ID" value="GAE69186"/>
        <property type="gene ID" value="JCM18909_2377"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850779" description="Apolipoprotein N-acyltransferase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="10">
        <location>
            <begin position="220"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="529" mass="56589" checksum="2AA85EF1CC75B010" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK91</accession>
    <name>W4TK91_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69221">
        <property type="protein sequence ID" value="GAE69221"/>
        <property type="gene ID" value="JCM18909_2415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="15506" checksum="0B3CE225D4B27FCA" modified="2014-03-19" version="1">MTADGTHPPLPEQSFAAVLADVPCSGLGSLRRRPEARWRRTPTDVEELTQLQRRLLISAVNLTRPGGVVGYVTCSPHRAETIDVINSACATLPVDVLDAPAMLPDIPNIAASGSTNTIQLRPHRHGTDAMFCALLRKRDESGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB8</accession>
    <name>W4TKB8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69390">
        <property type="protein sequence ID" value="GAE69390"/>
        <property type="gene ID" value="JCM18909_2599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="62"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="266" mass="28859" checksum="40FDEA26E6E6F271" modified="2014-03-19" version="1">MADKKKATATTSKRAALRAQQEAQESAKKRRRIIGVTAGVVIIAMVVVAVVFGLNHKSDDVPTTGQITPPSATKDGVYTLNPDKVKPGAPTVTVFQDYQCPACKGAEDVLGKPLNELSAEGKIKLEYHTLTFLDSNLHNDSSTRAAMAAAAADVVGKYEAYHDVVYRHQSKDEGAGYTDEQLRKEFAAEVGITGSNLTKFQRIYDNKQTEQFVKNGNDKGLQELQKSGNTGTPAFLINGKSWDGWADFMQSVPSADELLQAIKKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ1</accession>
    <name>W4TKJ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69316">
        <property type="protein sequence ID" value="GAE69316"/>
        <property type="gene ID" value="JCM18909_2517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17306" checksum="01281E59A6079FAC" modified="2014-03-19" version="1">MTPIFRLHDSPDGSSAVTLLRSVAPIQWFSGAAEVIVACLFVTCTFVTVAQPVFDNGACQLMLPLFAGAALVLEALCIVRDVRGVPSPREWSRSLTIVTCSFVALLVWAAVSIPFHEHLIYDDSMGVTRDLPLYASDASGGGDGYPSRGYFRVPDDRGGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU9</accession>
    <name>W4TKU9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68784">
        <property type="protein sequence ID" value="GAE68784"/>
        <property type="gene ID" value="JCM18909_1945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13799" checksum="12FD0112D01D07A4" modified="2014-03-19" version="1">MSLTAYEDSPFYKKLPSYVSDSMRDGHFYYMGYYLGDGAAAGLAGLAALHPTDTEDNSHTLDGDPILAYCIEKNSFQERHHQDTGTLTKWSELKPHYNDNLPNALPKIGWIAKKTATLAKLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW4</accession>
    <name>W4TKW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69073">
        <property type="protein sequence ID" value="GAE69073"/>
        <property type="gene ID" value="JCM18909_2257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11727" checksum="6C40C56F662DE4A0" modified="2014-03-19" version="1">MVIQDVKTVILVKIPVVVLDDVNSSIRDFSGFDGIYQCSGVCEFTTGAVDEKSALAHHGELLRVDHVVAHRHSGHMQGDGVAVVEQCFQVDELDDVVLLWVRREVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX0</accession>
    <name>W4TKX0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68809">
        <property type="protein sequence ID" value="GAE68809"/>
        <property type="gene ID" value="JCM18909_1972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9359" checksum="EB0F06D97F24098D" modified="2014-03-19" version="1">MAAPIAVTGITAGTVLGLIGVVHAAKGTSLKRWPLIGWAAPLGYASIIGVGSAAMKRDLDPGVRARLPLVLAIMHMSWGAGFLVGLGDRAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX1</accession>
    <name>W4TKX1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69177">
        <property type="protein sequence ID" value="GAE69177"/>
        <property type="gene ID" value="JCM18909_2368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13653" checksum="D916EA66C1F23AA5" modified="2014-03-19" version="1">MLRGIAHIEEVNRILEVLTSIGVTYEWSDDEHDLTLIRPAELNLDDMDIEAARRTRSVIMFLGPLMRFYDTFKLPYAGGCNLGARTVEPHLQVLRAFGLDVVATEAFTSATSPIAPSRSVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL61</accession>
    <name>W4TL61_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68899">
        <property type="protein sequence ID" value="GAE68899"/>
        <property type="gene ID" value="JCM18909_2071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6523" checksum="B3C5EDCE2A35E1C0" modified="2014-03-19" version="1">MLASAVGADCEKFRDGHRGPAHARSRLAMPWRGADDLHVSGDVEGRDRRDDLGVMVSTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD7</accession>
    <name>W4TLD7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69795">
        <property type="protein sequence ID" value="GAE69795"/>
        <property type="gene ID" value="JCM18909_3050"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8181" checksum="1E48B2C28A8B1A41" modified="2014-03-19" version="1">MSANGRVRDTSRSQAYIKQAIIAAASRSYLLVDSEKFPGVGAHSPFTLEEVSGVITTGPLPLDFDAHCESTVEVITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL4</accession>
    <name>W4TLL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69636">
        <property type="protein sequence ID" value="GAE69636"/>
        <property type="gene ID" value="JCM18909_2876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="4"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9137" checksum="5CE72A1E672C2F05" modified="2014-03-19" version="1">MADLANQQASTLSGGQQQRVAVIRAVASRPAVLLADEPTASLDDDNRWAVEKLLQDYLDDGGTIIMASHQPIDLPHLSVTVEATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR7</accession>
    <name>W4TLR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotriesterase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69696">
        <property type="protein sequence ID" value="GAE69696"/>
        <property type="gene ID" value="JCM18909_2945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016839">
        <property type="entry name" value="PhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="252" mass="27973" checksum="38FBF4B3375C0E6C" modified="2014-03-19" version="1">MLKTLQVVEKVPGLQVVQATGFHQQKVYLEWRQSWVNQYTVTQIADLLIADIVEGIDRFDYMGPIVERTNVKAGVIKWATAYGKITEWEKKSGQAVAIASKETGCPINTHVTAGTCGPEQARFLVDQGVDPAKIAIGHMQRNWDPWVHEQICKLGCYVELDGTNRIKYVPDNTRVNLVKTLGEKGYGKQILLGTDSGKASYQKVYGSVSGIDYDPAVFCPRLVEDEGVDRDYVNDLLINNAATFFGFEPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU2</accession>
    <name>W4TLU2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inositol monophosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69482">
        <property type="protein sequence ID" value="GAE69482"/>
        <property type="gene ID" value="JCM18909_2701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="238" mass="25853" checksum="0C07306FBB2C8E36" modified="2014-03-19" version="1">MPGSSIPGSGPSTIIKSTRKKPGDFVTDADRQAERELGAAVTKYAGGIVVGEESAFADPTILDAVPDADLVWVIDPIDGTKNFVHGSVDHGVMLAQLSRGETVRGWIWQPQYGHMWFAEHGAGVTCDGDEVTRGDSHSPVRAATTHEAYKIPSPVVEWRMAKWCCAVDYPLVCQDENDVTVYQHSYPWDHLPGALMVREVGGIVRTVDGAEYGSRETSGKLIVAADEEAYETVARLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU6</accession>
    <name>W4TLU6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">JCM18909_2354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TLU6"/>
    <dbReference type="EnsemblBacteria" id="GAE69164">
        <property type="protein sequence ID" value="GAE69164"/>
        <property type="gene ID" value="JCM18909_2354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8359" checksum="627419AE525BB59B" modified="2014-03-19" version="1">MAKKEGALELEGTVVEALPNAMFRVELKNGHRVLATISGKMRQHYIRILPSDRVVVELSPYDLTRGRIVYRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM09</accession>
    <name>W4TM09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopantothenoylcysteine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69229">
        <property type="protein sequence ID" value="GAE69229"/>
        <property type="gene ID" value="JCM18909_2423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="3">
        <location>
            <begin position="142"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="355" mass="37898" checksum="F9F326456CBC75AE" modified="2014-03-19" version="1">MGGAEWASGPHRGFFDDVPDVEHIRLAERADAIVVAPATADLLARLAGGHADDLLTTTVLATSAPVLLAPAMHTGMWQNAATVDNVATLRRHGLVVKAPATGRLTGRDSGPGRLPDPDEIAEFVDLLITVPECAAAMAQQDLAGKRVVISLGGTREAIDPVRYLGNSSSGRMGRAIAQVAAARGADVHVVAAHVDVAMPSDVQITRIDSTEDLAEAMDDLARRADIVIQAVAAADFAPVAVDTKIKKNTRATTPQVQRWPSNFTRLPTSWPASVLNRYRTGLSSDLPPKRHQTVTSFFEAGPGQARTQGLRPYGRERCERRKGVRQGWHRRNHGSPAGAGSSYHRIEVAGGCRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM20</accession>
    <name>W4TM20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding protein Era</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69443">
        <property type="protein sequence ID" value="GAE69443"/>
        <property type="gene ID" value="JCM18909_2658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8501" checksum="F55B6D08D721A46D" modified="2014-03-19" version="1">MSDDEMPSLADLMDGDDEDISDVDYVTARVAESTEPDSTPGSSASSGAQMPASRLSPTPWLVPRSPLPPRSLRPPVTSSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM37</accession>
    <name>W4TM37_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69801">
        <property type="protein sequence ID" value="GAE69801"/>
        <property type="gene ID" value="JCM18909_3056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="182" mass="20201" checksum="CAAE58996CF57DF2" modified="2014-03-19" version="1">MRGVTLDDRDMKYYCAMLTHGITRQLDFMLLAVAVALGCFGLNAWVILRDSQAPLVESLGVPAASWLVALILGLILRPFPTKLTGKVDATAMRNAIAKKTMMAFCGMTWPALILFVLAFLLYLPRTVVLLAMIAHGATLFLLLHSTDQRLEQFAETWCGDHYDPANPEIDTFLYGTRSVSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM54</accession>
    <name>W4TM54_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JCM18909_2850</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69612">
        <property type="protein sequence ID" value="GAE69612"/>
        <property type="gene ID" value="JCM18909_2850"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GAE69612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5858" checksum="1D57685C1FC4ADBA" modified="2014-03-19" version="1">MTSFFVSNEVGMGVVPDTPAGRLFRDELGRLNAAVGEACDEVWMCVAGIPKRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB4</accession>
    <name>W4TMB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69548">
        <property type="protein sequence ID" value="GAE69548"/>
        <property type="gene ID" value="JCM18909_2776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13426" checksum="24BCC34FC63581AA" modified="2014-03-19" version="1">MSTREEARDWSVDLATNIHLAKPVVYVEPRPSANKWNITAVGQPLWFHNPGSERHTSSDSSRGIIVSLDATRVETIYNTGEKTVRCAHSTPRPKKCRSASPISGLRLHLPAPRKLHRAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB9</accession>
    <name>W4TMB9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70130">
        <property type="protein sequence ID" value="GAE70130"/>
        <property type="gene ID" value="JCM18909_3426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10732" checksum="A92DA5AC4F063854" modified="2014-03-19" version="1">MLGWSHIGDAHELKHFKKGTIFAKTTVQHGKHDGTVVGTQGLNERGVNIGFHDFVSDPPQRLCNGATRLQRDVALVAESSGKDDDWLQHAPIQPVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI5</accession>
    <name>W4TMI5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Aspartate ammonia-lyase</fullName>
            <shortName evidence="5">Aspartase</shortName>
            <ecNumber evidence="3 5">4.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-aspartate = fumarate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16601"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="4.3.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.1" evidence="3 5"/>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70200">
        <property type="protein sequence ID" value="GAE70200"/>
        <property type="gene ID" value="JCM18909_3498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006531">
        <property type="term" value="P:aspartate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004708">
        <property type="entry name" value="ApsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00839">
        <property type="entry name" value="aspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="7">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="8">
        <location>
            <begin position="410"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="490" mass="53776" checksum="727780B8765FA8C1" modified="2014-03-19" version="1">MAEIRIEEDLLGKREISNEHYYGIHTLRALENFQISRGCMNDEPDFIRGMVQVKKATALTNKQLKVLPGDVADAIVAACDAILDDGRCMDQFPTDSFQGGAGTSINMNTNEVVANLALEMLGYPKGTYDVIHPNDDVNKSQSTNDAYPTGFRLGVYALLEGLKRAVADLADSFDAKAKEFADVLKMGRTQLQDAVPMTLGEEFDGYAHNIRAELDRLDVGSDLLVEVNLGGTAIGTRINTPDGYAELAAEKLAEVTGYPIRPSTNLMESSYDNGAYIAVHSIIKRLAAKISKICNDLRLLSSGPRAGLKEINLPEMQAGSSIMPAKVNPVIPEVVNQICFKVFGNDVTVCFAAEAGQLELNVMEPALSQAMFESIHLLTNACDTLRSKCIDGITANVERCREYVTNSIGIVTYLNDVIGHHQGDLIGEEAARTGKSVREVVLEHDLIPEERLDEIMSTQNFLHPRYSGRTYEPSDRGLPEDPRTFVSERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN1</accession>
    <name>W4TMN1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TsaC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69966">
        <property type="protein sequence ID" value="GAE69966"/>
        <property type="gene ID" value="JCM18909_3241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14164" checksum="65182C8C3B558302" modified="2014-03-19" version="1">MDLGETNGTLAVRVPDQDQTRELLRMTGPLAVSSANKSGHPAALTAQEAADQLGVEVAVYLDAGPSRVGESSTIIDFVSTTDGKVVRQGALLLEAIHEVAPDVIGMEPPAIDQDSSENHGSDVAPTEAASTQSEIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN3</accession>
    <name>W4TMN3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69683">
        <property type="protein sequence ID" value="GAE69683"/>
        <property type="gene ID" value="JCM18909_2928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb1_3" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22291" checksum="F63502455BAEB1F3" modified="2014-03-19" version="1">MIIGAYYLTMALDGLKGEGRAFTSLAEAIMAHDLGELEIGAKIKLRLKGIVPPHDETVRADGSVILDTTLGQALFNEVLPDDYPYVDFLVGKKQIGKIVNDLSERMTQLEVAHVLDNLKDIGYKWGSLSGVTVSIGDVQTPPTKPEILAGYETRAAKVDREYDRGAVTEEERRQDLIQIWTEATAELTAAMELTSPRLIRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMP7</accession>
    <name>W4TMP7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69817">
        <property type="protein sequence ID" value="GAE69817"/>
        <property type="gene ID" value="JCM18909_3072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTAD" evidence="2">
        <location>
            <begin position="416"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="607" mass="64713" checksum="671C160941A7DF42" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR7</accession>
    <name>W4TMR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70006">
        <property type="protein sequence ID" value="GAE70006"/>
        <property type="gene ID" value="JCM18909_3285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20994" checksum="C9A841369813551C" modified="2014-03-19" version="1">MSRANADGNNSAMKKKLLRQGLEVPALAIIVFAGDGRAGPPRRADSVLAGTWSGRVIGTSRGGHGGGPAAFGIATLQQRYCFAREDGKRNLIMQAITTGVQLIILVTMFVFFRLSMPLSSWRLLRLLPTLLERWCGWWWLLASSAVLAWGRLTDCGPSSLWPRSLLRFRHTSSLMGSTLRVMVRGSVTLAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU9</accession>
    <name>W4TMU9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70305">
        <property type="protein sequence ID" value="GAE70305"/>
        <property type="gene ID" value="JCM18909_3613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="12"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="205" mass="22642" checksum="0AE148C7DB0D65DB" modified="2014-03-19" version="1">MVRYSDLLESLFLIHRLPAWSRNLTKRQIQRPKVFLTDTGLNAALSNMDAAHLSSMQGADHLGPLLEQFVVCELLRQQGWSATPFKLFHYRDRQGAEVDIIVETPAGIIAVKVTSAVAATARHFQHLKALRDRLGDEFLAGIVLTTGTGQKKPAIGSNRFPSRHCGRDETRLGHIGLVGAARNQPEPHQDGPDPSARAPARMQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX4</accession>
    <name>W4TMX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell envelope-related function transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69539">
        <property type="protein sequence ID" value="GAE69539"/>
        <property type="gene ID" value="JCM18909_2766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5728" checksum="B711CC033CD29982" modified="2014-03-19" version="1">MTGASSANTHKTAMTPPSHSGLKKSPQTPAPRPSPDNHDVSQSVTDACAYNPQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN41</accession>
    <name>W4TN41_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69624">
        <property type="protein sequence ID" value="GAE69624"/>
        <property type="gene ID" value="JCM18909_2863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4118" evidence="5">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="279" mass="29171" checksum="2E06916754D611F4" modified="2014-03-19" version="1">MNRSSSSAALLIGAVAVPIAVCAVLSALIDVFVAPAAALVLVLVIVIVCLRGSWLVDALVIVVSAIGFDFFLTYPYRSMKIASRPDIEVTIVLFVVGAAIAGISRWALTASDLAERRQGYVTYALDARSGDMSRDEVAQRLAGLVGAEAGAWVDGTPPSGEAVIQALPPCAPTSVWRIPLGWGSRPIASSVSPRPVATSVSRRHRVTCVPPPSRCVPPVCSLPRSAEWPVGSGTSFSALPGPRHDGASWLPAVQPTDDIGGFDSEPDEITTQVTVQGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN58</accession>
    <name>W4TN58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiaminase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69848">
        <property type="protein sequence ID" value="GAE69848"/>
        <property type="gene ID" value="JCM18909_3107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034641">
        <property type="term" value="P:cellular nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046483">
        <property type="term" value="P:heterocycle metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901360">
        <property type="term" value="P:organic cyclic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TENA_THI-4" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10917" checksum="F6DC0EB632F358D0" modified="2014-03-19" version="1">MNVFTPSSPAPLTTAGIAVAPSGRVAALSAGRSEAWTTAINHRFVNELFSGELDDAQLTHYVIQDNQFFSFLSWNCWARPSSVPKPWRRSWFSDVSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN81</accession>
    <name>W4TN81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69982">
        <property type="protein sequence ID" value="GAE69982"/>
        <property type="gene ID" value="JCM18909_3258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="115"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="268" mass="28514" checksum="46AA8E9A09B08063" modified="2014-03-19" version="1">MRCHTSDAIDLLGVHSHIGSQIFDTAGFEVAARRTMKLLEQFHQATGSALPELDLGGGFGIAYTSQDSPATAESLAGALREIVTVEARGRGMEVPHISLEPGRAIVGPTMMALYTVGTVKPVDLDTGAQRMYVSVDGGMSDNIRPALYAAEYSAVIANRTSEVAPVLCRIVGKHCEAGDILVRDVYLPGDVSPGDVIAVPGAGAYSRSMASNYNHVPRPAVVSVNEDRGVLVLLRRENIDDLLALDPGRSVPRCHARNASKSPITHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA2</accession>
    <name>W4TNA2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70007">
        <property type="protein sequence ID" value="GAE70007"/>
        <property type="gene ID" value="JCM18909_3286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="380" mass="41784" checksum="A7CA442EE1087ABF" modified="2014-03-19" version="1">MPESRDDDVYDLLRLPEVVPPIDVYDSLDIDAVTFGADVSRRSLRRLGADEDFDRTRVIPGIITSPPASAAPEAPAEGSLRRASIVMAAGTMVSRILGFVRTYLLTVIAAGTSLTLDAFQAANTLPNVVFILLSAGVLNAILIPQITRAMKQPDGGQEFVDRLLTVSFASVLLVTTVATLASPWLLDLYFSSSGATRHLTIFFGFICMPQVFFYGLYAILGQVLNARNQFAAFMWSPVLANVIQIAGLVWFLVQFGAHPDPATWTPEMVWVLAGTMTLGIIIQGLFLIIPLHRGGFRWRPRWGIRGYGLGAAARITVWTFTALVIAQFAGIIMKKMLSHVRLVHPEVSSSISAYDNAFLIFLCCRRASLRRQFLLHSSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF4</accession>
    <name>W4TNF4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">cAMP factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70271">
        <property type="protein sequence ID" value="GAE70271"/>
        <property type="gene ID" value="JCM18909_3575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010860">
        <property type="entry name" value="CAMP_factor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07373">
        <property type="entry name" value="CAMP_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23111" checksum="81239B0C0B0F6DB1" modified="2014-03-19" version="1">MPQAQVPASEAPKVNYSEEIRKLLDTAFELRTAIESIIAGKVPPVDLSTIPARVDLLTTSVKTIQQANHNLVNKVEAAHVELGFSITRALIRTINPTSTAAQLAESKADMLSTYAKVAAYRDLKPTDAATVYVKNRLNTKIWQTRINRDKYLLGKNAEGYKAINKALTHATGVWFNPATTVKQVDDEVKALDLAFQAALDRGPADGKLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI7</accession>
    <name>W4TNI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70301">
        <property type="protein sequence ID" value="GAE70301"/>
        <property type="gene ID" value="JCM18909_3609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9438" checksum="8EFAF9AADB8460EB" modified="2014-03-19" version="1">MARAVVRPGSQPFGRSDAQLAVMGEDLRRVPASRNVPDNLASCDVDDGNLIVSRIGDVETLAVLGESQTGRIGTYQLGTVAVDRDGGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL3</accession>
    <name>W4TNL3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69799">
        <property type="protein sequence ID" value="GAE69799"/>
        <property type="gene ID" value="JCM18909_3054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="39"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="30104" checksum="0F8640769343281B" modified="2014-03-19" version="1">MIFTLLLAFTDWSSLGSAHFVGLENFTYLISDHLFYKSLGNTLILWAMGTIPTLIIATIVALMLNKTIRFSTTYRVIYLVPNITSMVAMGILFSSIFSSQFGLANAVRNLLGQENIAWLQNEWGIKIAISSLTVWSFVGYNALLILAGLQAIDKTQYEAAAIDGANGWQTFFHVTLPQLRAIVLFITLMSTIGSLQSFTEAQVLTSSQSAGAASAGGVNNSGLTMVLYFYSVAFQENRYGYGATIAWGVFVVVLFFSIINWLVTREHDRKVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM0</accession>
    <name>W4TNM0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrolipoamide succinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69988">
        <property type="protein sequence ID" value="GAE69988"/>
        <property type="gene ID" value="JCM18909_3264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="4763" checksum="282DF8C7C6245F2D" modified="2014-03-19" version="1">MSEKLPGFFDGLVGITRPPSSAPSVGQHSVHIREEQDLLEKAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW1</accession>
    <name>W4TNW1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobN component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000061">
        <property type="protein sequence ID" value="GAE70660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70660">
        <property type="protein sequence ID" value="GAE70660"/>
        <property type="gene ID" value="JCM18909_4031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="296" mass="32250" checksum="269C2122BE54A29C" modified="2014-03-19" version="1">MIDRAVRMVAALPEPDDDNMLRAHVEADVTEMIARGVDVEQARRKATLRVFGCPPGGYGAGVEELIETKAWQDKADLGRAYIAASSHAYGEGVFGQVETERFTASLKRMDVTVKNEDTREYDMLSCTDFYNYYGGLIAAATTVRGEAPMSLVGDSSDPSRIATRTTTEEARLILRSRILNPSWIEGLQRHGIKEPATYRRYSISSSAGTPPPTSSMTAYGNELRVVTPSTRRCRSGSGRSIRTPCTTSSTSCLTPPNVTSGRPIRTPSRNSRTPTPISRAPSKRSPTTPRATQTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ2</accession>
    <name>W4TNZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70262">
        <property type="protein sequence ID" value="GAE70262"/>
        <property type="gene ID" value="JCM18909_3565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6627" checksum="C81FA58445A34C93" modified="2014-03-19" version="1">MTILAQCRLLGTIETLLIRPPTPDGRAMAHILDITLAVILILRALRGWTEEQFLGSPASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP73</accession>
    <name>W4TP73_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70208">
        <property type="protein sequence ID" value="GAE70208"/>
        <property type="gene ID" value="JCM18909_3506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5710" checksum="DD34FCE967CFE773" modified="2014-03-19" version="1">MSGGTHPSMDGADNTAVHCGNHVRHCDNCHSSWQLVPSPAGLPQRRWDGSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP99</accession>
    <name>W4TP99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosomal replication initiator protein DnaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70541">
        <property type="protein sequence ID" value="GAE70541"/>
        <property type="gene ID" value="JCM18909_3881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_DnaA" evidence="2">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21852" checksum="EEF227A697A2384C" modified="2014-03-19" version="1">MTMHSSTAMVAVPNEFARDRLESKMRYELEELLSDHFHKAIHLAITIDPDLELALGAPDHEDEEEEVPPAQFVPKVTVGVTEPSARPTTTINDDEGNRLNPKYTFDSFVIGASNRFAHAAAVAVAEAPGKSYNPLLIYGGSGLGKNPPAACHRALRHVVLRQRQSEVRLYRGTHQRLHQRHRHQPHHGVPSLLPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPA2</accession>
    <name>W4TPA2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA recombination and repair protein RecF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70546">
        <property type="protein sequence ID" value="GAE70546"/>
        <property type="gene ID" value="JCM18909_3887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="7210" checksum="77E71C77109132E2" modified="2014-03-19" version="1">MFVERLELVDFRSYVRADVPMTAGATTFIGLMAKGRRTWLRRWNTFRRCRRIASAMTPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPL9</accession>
    <name>W4TPL9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70358">
        <property type="protein sequence ID" value="GAE70358"/>
        <property type="gene ID" value="JCM18909_3673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="14689" checksum="4EB8322D142E7286" modified="2014-03-19" version="1">MIGSGGSGGREGPTAQISATVISSLCKKLKIATPDARIAVSAATASGIGAIFRAPLGGALLGAELLYRDDMESDAIMPSLVSSIVAFVVFGSVYGFEPIFGSLNGVQFSQPLQLIWFVLLGLTAGLMGKLYVEVFYGGTTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPP7</accession>
    <name>W4TPP7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C4-dicarboxylate transporter DcuA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70199">
        <property type="protein sequence ID" value="GAE70199"/>
        <property type="gene ID" value="JCM18909_3497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015556">
        <property type="term" value="F:C4-dicarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004668">
        <property type="entry name" value="Anaer_Dcu_memb_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36106">
        <property type="entry name" value="PTHR36106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03605">
        <property type="entry name" value="DcuA_DcuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004539">
        <property type="entry name" value="C4-dicrbxl_trns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00770">
        <property type="entry name" value="Dcu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="426" mass="44154" checksum="8354CDA8FA030497" modified="2014-03-19" version="1">MMLFIQLAVVLLFIFLGARKGGLGIAYAGGAGVIALGLLGCKVDPGTGIPWDVIGVIVSVISCVAAMEVAGGLELLVMLSERILRHNPKRITFLAPTVTFFMTVLCGTGHVAFATLPVIAEVAKEQKVRPSRPLSIAAVASQIGICASPISAAMVAMAAIVGPLGVSYPKLVLVSIVGGYVGSMIGAVVSSKLGCELELDPVYLQRLEKGQISHRGADNYNIKPYARRSLIIFVVSLVVVMAYAAAITAVDKPPLPRGAAIMTFMMTAALVIATLCKVPLNEITSQATYKSGTSAAICVMGVAWLGNTFVSSNIDTIKAAGSGVIHSAPWLLFVVLFLAASLLYSQAATTVTFMPVAAALGLPASVLVGCFAAASALFLLPTYPTVVAAVEMDDTGTTRIGKYIFNHSFLIPGIVSISVACLASYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQH9</accession>
    <name>W4TQH9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CobN component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000061">
        <property type="protein sequence ID" value="GAE70663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70663">
        <property type="protein sequence ID" value="GAE70663"/>
        <property type="gene ID" value="JCM18909_4034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22130" checksum="C79831E1CECD711B" modified="2014-03-19" version="1">MEKNRRESGLPLPWIHIQPTSGDDDGLLAAQDWASGLDDGTWRGLIGLLEMGGPDNVEAALRILVDRVRGGSAPIPDVIPAPTEGIWHPRHGLFTNLAEYRHHLDPDLPTVGITFPRSYWLEHNTAHIEALVEAIEGLDANTVPFFCLRLPDARRGNPGMAQTLETLLRDEDGNRVIDTLIDVHGMSMTAGVPANADATRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQI4</accession>
    <name>W4TQI4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70489">
        <property type="protein sequence ID" value="GAE70489"/>
        <property type="gene ID" value="JCM18909_3816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="188"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="369" mass="38458" checksum="3DB27649974BBD5E" modified="2014-03-19" version="1">MLVLLALLGVGVAALHGDYDDSFTIPGAPSQVAYDKLQVAFPQASALSANVVVTVPDGTNISSKLIRSRIEKGVDELKDLPLVTGATSPWNKYVTGMVNKDHTAAVIQVELGQNNAVTFPDSGRHDLIRVGNEIRSDLPSGSHVYVGGQAFEATLPSLSITEVIGVGVALVVLSVTLGSLVAAGMPIVTAVLGVGVTYAGMAILTRFTTVNSVTPMLAVMLGLAVGIDYALFILSRHRDQLRDGAEVQESAARAVATSGSAVVFAGATVVIALIGLAIARIPFLTVMGIFAAIGVALAVVIALTMLPAFMGLMGERLRPRRSRADTKARTAGRTERSGGIFGWWVRTVTRVPLVTILVVVVGLGAWLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQL4</accession>
    <name>W4TQL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70519">
        <property type="protein sequence ID" value="GAE70519"/>
        <property type="gene ID" value="JCM18909_3852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8947" checksum="C5A8AABB671CA8E0" modified="2014-03-19" version="1">MRNRITWMWNAYPYESSDLVVVQKPLSFVASFWEVLGTLLAGVTGVLITNIERSRPDVMFDRLASSGATHLFLRHLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR30</accession>
    <name>W4TR30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000072">
        <property type="protein sequence ID" value="GAE70704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70704">
        <property type="protein sequence ID" value="GAE70704"/>
        <property type="gene ID" value="JCM18909_4085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="14606" checksum="00910BA43B943E14" modified="2014-03-19" version="1">MVITEGINVEGVKLALIVVPRPDRVAGTPSAKPPTATNLPTAGVVSAMGLYLLTASNVLTLVGGVAASCLFLVLAVSLAVVVVRFNALSTPHAHALQVTLGWLTVLVALILGITRQWTRIYRVYVNGKTERFHHALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE00</accession>
    <name>W4TE00_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_25</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66996">
        <property type="protein sequence ID" value="GAE66996"/>
        <property type="gene ID" value="JCM18909_25"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE66996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="168" mass="17973" checksum="65D221750577358C" modified="2014-03-19" version="1">MWWTKGPSADEMTRLRAVLGFNDVKVLAHGRGDGAIVIAVTEGLVVLTDEVDSAVAWHEIVRGRWNGETSTLSWEFLDGSGASVVLSKPGKIPEVFRAKITESIAATRTVPVHGGIVLIAGRIPAGRLADVDGAITWTAVARDSADLNDPETRQAVMEATDSLKNEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TET1</accession>
    <name>W4TET1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase amidotransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67301">
        <property type="protein sequence ID" value="GAE67301"/>
        <property type="gene ID" value="JCM18909_347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5684" checksum="8967B78FBE7C1C38" modified="2014-03-19" version="1">MSDPVRVGIIDHGSGNLHSARRALRQVGAEVIVSNDPSAYSIPTLLSSPAWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEY9</accession>
    <name>W4TEY9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinate dehydrogenase iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_12</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66983">
        <property type="protein sequence ID" value="GAE66983"/>
        <property type="gene ID" value="JCM18909_12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE66983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12151" checksum="3F9A6AC73046CC99" modified="2014-03-19" version="1">MMPQGRQERSKRARRMINALDEEFGPCSLYGECVEACPVSIPLVAVAGSTGSVGVPDSGEHAAKTTERLVAQRRAGTRRSRVPARHAVAGAVEVQANVKNRGEVGDGADTAVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF49</accession>
    <name>W4TF49_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="6">2.2.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_193</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67152">
        <property type="protein sequence ID" value="GAE67152"/>
        <property type="gene ID" value="JCM18909_193"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="11">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase_C" evidence="12">
        <location>
            <begin position="113"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE67152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="25516" checksum="051FE208F2479192" modified="2014-03-19" version="1">MALYSTFLNRAFDQLLMDAGLHHAGVTIVLDRAGITGTDGASHNGMWDMAMCGIVPGLMLSAPRDRQHLVSVLNEAVDIDDRPTVIRYSKDPIPDDIRIVTSHDGLDVLCDGPEDGILLVAHGQLCAEALAAVDQLDFPVRVVSPRWSLPVCGGLIEEAARARAVVSVEDGLVVSGLGSHLAAALSQRGMWRPIRSLGIPQRYLDHDLRSAIIAELGLDSRGIADAVSQLVAQLDGECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF94</accession>
    <name>W4TF94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heat shock protein 60 family chaperone GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67640">
        <property type="protein sequence ID" value="GAE67640"/>
        <property type="gene ID" value="JCM18909_713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12936" checksum="8A9080C4A8BCD09D" modified="2014-03-19" version="1">MIEDPYILIHSGKISSMNDLLPLLEKVIAAHGSLFIVAEDVDGEALSTLVVNKIRGTFSSVAVKAPAFGDRRKAMLQDIATLTGGQVVAPEVGSSSTRWASRFWPCQEGCRYQGQHHHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFC9</accession>
    <name>W4TFC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67138">
        <property type="protein sequence ID" value="GAE67138"/>
        <property type="gene ID" value="JCM18909_178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022183">
        <property type="entry name" value="DUF3710"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12502">
        <property type="entry name" value="DUF3710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25562" checksum="008FE642E2CA6DB9" modified="2014-03-19" version="1">MFGRKKRNDDVETDEVIDEDLETTEEVPDDLDAKEAPEEDESSEEEDTSAYRINLDREDGPFDIDEVDLDADDVERIDFGSLIVTPFENMQMQIQLDQTSGAVQSLLVVQGNSAIEIALFAAPASTLMIDEVHEEMVRGTEVQGGEADVGPGPMGAELRRIVPMKGPDGEDGYHVSRTWLAQGPRWLLRGVLMGESALGEKLDATGQLLLEFFSATLWCVVTTARASLATLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFE6</accession>
    <name>W4TFE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67486">
        <property type="protein sequence ID" value="GAE67486"/>
        <property type="gene ID" value="JCM18909_548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17142" checksum="20E3128E74558CCB" modified="2014-03-19" version="1">MFNLEYPQSVVVVDDYVTAQKIVDQLSDKEFPVENLCIVGTDLKTVERVTGRRTWGSVLGQGAVSGIGMGLLVGLMMMFFTSGEAVLLLLLTGLIVGVVIGMITAAITYSMSGGERDFNSVQQVVATHYEVLAEHKVAAQAREMVSDMPFMRTKAFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFR3</accession>
    <name>W4TFR3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67273">
        <property type="protein sequence ID" value="GAE67273"/>
        <property type="gene ID" value="JCM18909_319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9584" checksum="BA2910261A6E761C" modified="2014-03-19" version="1">MVDPIRDIQIVLLTNMRHSPVVEPPNEFATGAFPLAHYVGLISRVYSALAEDGRVTDVDAPLPERAASSPTRTHRPRVVPRRRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT4</accession>
    <name>W4TFT4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67830">
        <property type="protein sequence ID" value="GAE67830"/>
        <property type="gene ID" value="JCM18909_917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PTHR31756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25034" checksum="D7541A029F9CB378" modified="2014-03-19" version="1">MCVVHTLVLPDMRRMVSDACEEMGIRELDLMGPMLEAMEEASGLDADAVPRRPVGVEADYFTRISAMEFAVRNDDGAIPDRLTEADICLVGVSRSGKTPLSIYLGYLGYKTVNVPLVPGIAPPTELAAVDRWRIVGLTIDAQRLLEIRGRRVRGLGGFGNEDGYADLAAIYEELDEVGKIQRRLGCPIIDTTGLALEESATKVIDVVDQRAKTAGTRLRKPAGSYRMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX5</accession>
    <name>W4TFX5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IMP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67686">
        <property type="protein sequence ID" value="GAE67686"/>
        <property type="gene ID" value="JCM18909_764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9182" checksum="A589527B0ACA5409" modified="2014-03-19" version="1">MGVGMGQVNRVDSCKLAVERAGDRAAGSVAASDAFFFPFADGPQVLIDAHIAAIVEPGGSIRDDQTIEACRTAGVPLYFTGTRHFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA1</accession>
    <name>W4TGA1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67179">
        <property type="protein sequence ID" value="GAE67179"/>
        <property type="gene ID" value="JCM18909_221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="170" mass="19374" checksum="27DA10C5312D372B" modified="2014-03-19" version="1">MTEDYCLEFAEDLVGVPDPFRRFWTPYRMAYISGENKPRGDRPEDGCPFCSAPQRSDEDALIVHRGEHCYVIMNLYPYGPGHMLVCPYRHVAGYIDATQDEVVEMAQLTQDAIRTLQEVSRPQVQRRHQSGGIRWRRGCRAPASTRHPAVDRGYQLSAHRCRGSCCTAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF2</accession>
    <name>W4TGF2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68035">
        <property type="protein sequence ID" value="GAE68035"/>
        <property type="gene ID" value="JCM18909_1141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9174" checksum="973D12514CCB2661" modified="2014-03-19" version="1">MADPQLPFFIKWTSPTELLPSSLSGNVTLTSVEMSGSRQRVEDWLGETIPDEVEGITFHFASPNGHPGIDAVTFNTPSRGCVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL9</accession>
    <name>W4TGL9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Imidazoleglycerol-phosphate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67299">
        <property type="protein sequence ID" value="GAE67299"/>
        <property type="gene ID" value="JCM18909_345"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15422" checksum="D3E880B74D6AB807" modified="2014-03-19" version="1">MTHRRAHVYRETSESTVDVAIDLDGAGESTISTGVGFYDHMLTTLSKHSGIDMTITTTGDVEIDGHHSIEDTAIALGQALAQAWGINAVSRVLVTPWFPSTRPLPSALLTLLDDRGWRARVNPRGRRTFVLVVLACPTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGQ3</accession>
    <name>W4TGQ3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ORF">JCM18909_676</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67603">
        <property type="protein sequence ID" value="GAE67603"/>
        <property type="gene ID" value="JCM18909_676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="289"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="461"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="658" mass="72033" checksum="142ADFB6133D168F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR3</accession>
    <name>W4TGR3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67722">
        <property type="protein sequence ID" value="GAE67722"/>
        <property type="gene ID" value="JCM18909_801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8808" checksum="8EB46951558377C6" modified="2014-03-19" version="1">MPHSAQKIYEALGGEGVWAAQPELIETDGAPILMGDYATEQASWGRHDIAVGTPLSKPSPIFRKLDAKLAQTGPQWAPVNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS5</accession>
    <name>W4TGS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67354">
        <property type="protein sequence ID" value="GAE67354"/>
        <property type="gene ID" value="JCM18909_404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="6">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_2" evidence="5">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18750" checksum="5A4A906DDD278C17" modified="2014-03-19" version="1">MLRTHDAGTLRASDIGKEVTLAGWVGHRRDHGGVAFIDLRDASGLAQVVIRDEILESSGAHDLRNEYCIRVTGVVEARPEGNANPNLPTGEIEVAITELEVLNPSAPLPFQIDEHVSVGEDARLKYRYLDLRRPHQHEALVLRSHVTHAIREVLDRHNFFMTSRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT2</accession>
    <name>W4TGT2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thump_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67633">
        <property type="protein sequence ID" value="GAE67633"/>
        <property type="gene ID" value="JCM18909_706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="308"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="395" mass="42500" checksum="F7C742EC8BAD8F64" modified="2014-03-19" version="1">MARRLVSSEGRKALDLAGAEADPDSLLAATRLRRQIDGDLAAAVLDQISLRRRAVAKIGPVAASMLWTRDGLEQATRGDVSRWRAHRLKEAGFTHVVDLGCACGADARACLDAGLEVTAVEVDPVTAELARHNLPEAHVMCADAMAVFADFRAHGDAVIMLDPARRTGRGRTWRLEDVQPPWSFVMTVLESVPAVVKLGPGVDRSQLPDFPVTYVGHRGDLVEVTVWSGCEDQRAADRAVLVGPAGIEELPGRCPAPAPGELGPFVAEPHPAAIRAGSLSAIDGSLHAVSEGIAYLTAEEPVASPWLTWFAVKEVLPLDVRALRSWVHHHHVGTVEIKKRGVDVDPVTWRRKLKPSGPNRVTVICTPTTGRTKALVCDRVRLPYGLFGASSDVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW5</accession>
    <name>W4TGW5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67668">
        <property type="protein sequence ID" value="GAE67668"/>
        <property type="gene ID" value="JCM18909_744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19410" checksum="339429C4798A4355" modified="2014-03-19" version="1">MPIYAPVTAGAASPADLLADLNEPQREAVLHAGSPVLVVAGAGSGKTRVLTRRIAHLVGERGVHPGSILAITFTNKAAAEMKARVVDLVGNRAKPMWVSTFHSAAVRILRTDIDRLGISRNFSIYDDTDAKRLITLVTRDQNLDPKKFQPRAIMNWISHQKKRAHCPGSSSRGCQERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH15</accession>
    <name>W4TH15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68071">
        <property type="protein sequence ID" value="GAE68071"/>
        <property type="gene ID" value="JCM18909_1183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011618">
        <property type="entry name" value="PTS_EIIBC_GUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004702">
        <property type="entry name" value="PTS_sorb_EIIBC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39427">
        <property type="entry name" value="PTHR39427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03612">
        <property type="entry name" value="EIIBC-GUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51102">
        <property type="entry name" value="PTS_EIIB_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-5" evidence="4">
        <location>
            <begin position="3"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphocysteine; by EIIA" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="293" mass="30915" checksum="41AB12C393EB1125" modified="2014-03-19" version="1">MTEYHSVTVSHGSGGYGGPLTITPTEAKHKLVYIVGGGVRPPVVDRIAELSGAEPVNGFNTSVPDEETMAVIIDCGGTLRCGIYPRKGIPTINVMPTGKSGPLAQYINESIYVSAVDADQVRLADSPTSSATVTSPAIAAAAAPRSKAGTAGTVQGEWSTDKKISEAVAEKKNKTVMDKIGLGAGKVISVFYQAARDEVQAMLTTVIPFMGFVAMLIGIINASGFGTWFTKLLIPLAGNGIAHRPWPHLLAALPVAPARPRSRHRSDHRNSHRRGDRQAQHPSQLGPSSAVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB9</accession>
    <name>W4THB9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67539">
        <property type="protein sequence ID" value="GAE67539"/>
        <property type="gene ID" value="JCM18909_605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="21692" checksum="71F7E2A6326C0B11" modified="2014-03-19" version="1">MEGLLSIDGTLFIGNNPMRHGRAAAKFREAGVDAAVVNDRQPIGGKIRAVATFLGDPKAGDKLAGAVERQLAEAAAITRARQGHRLRILAVTASGAGGANAVMGTGMASAEMIAACGATSVGVRAGLRGYSVKFTDEGLLSMKPDVILTGDGDLKRWGGLEGYLKAFPTLAQTPAGRKNHVFVMPSEQIKVSGVGVGAGAIALARALDALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD4</accession>
    <name>W4THD4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperone protein DnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67848">
        <property type="protein sequence ID" value="GAE67848"/>
        <property type="gene ID" value="JCM18909_938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="457" mass="50310" checksum="65857B60C05E5829" modified="2014-03-19" version="1">MKATNGDNHLGGDDWDQRIVDWLVTQFKNANGIDLAADKMAKQRLQEAAERAKIELSQASETHINLPYITAGAAGPLHLDEKLTRAEFQRMTSDLLERCRTPFNAVMKDAGLNVSQIDEVILVGGSTRMPAVAELVKELAGKDPHKGVNPDEVVALGASLQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTKIIERNTTIPTKRSEVFTTAEDNQPSVMIQVFQGEREFVRDNKSLGNFELTGLMPAPRGIPQIEVTFDIDANGIVHVHAKDMATGKEQSMTVTGGSALGKDEIDRMVKEAEANAEADKKRREAVEMRNEADALAFRTEKLLDENFDKIPEDTKAPVTEAIATLKETLKGTDNDDEVKAAMDDLNQKRPPWARRSTLLFSRLRPRTRRARTQSRPARSLVMTPSWTRKSSTTRTRRSDRGHSLTPAPPPGRHSDGPAAGTHVKEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD8</accession>
    <name>W4THD8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin carboxyl carrier protein of methylmalonyl-CoA:pyruvate transcarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67907">
        <property type="protein sequence ID" value="GAE67907"/>
        <property type="gene ID" value="JCM18909_1001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="43"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="11681" checksum="820CEEA416AC2742" modified="2014-03-19" version="1">MKLKVTVNDVAYDVDVDVDKTPNAPMAPILFGGGVGGPMKASGGGAGKAGEGEVPAPLAGTVAKILVAEGDAVKAGQVLLTLEAMKMETEINAPADGTVKGILVAVGDAVQGGQGLVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ0</accession>
    <name>W4THJ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinone-specific isochorismate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68261">
        <property type="protein sequence ID" value="GAE68261"/>
        <property type="gene ID" value="JCM18909_1385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="15"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25150" checksum="BED1A672FB4DB70C" modified="2014-03-19" version="1">MAPGGATCPGHHGPGELDQIVLMRDIEAKAVCPIDPRWIVETLRRQFPNAYTYLVEGSVGTTSKLTVGVSKSLITSRVLTHSPATDANHQTLLTALQGKGPLASYHDEIVERTCARLEQFCDTVHVPDCPGCVYNDASTYLVTDVTGIHSPDQGSCLALVQALCPPAFVTGLPPHRAMSVLAEVEHVDRGRVSGPTGWVNSLGNGQWVTDCRGGQIDATDFTRPYLLWPPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL0</accession>
    <name>W4THL0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68286">
        <property type="protein sequence ID" value="GAE68286"/>
        <property type="gene ID" value="JCM18909_1410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="45"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="531" mass="56585" checksum="677C941509CD6CAF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL2</accession>
    <name>W4THL2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67664">
        <property type="protein sequence ID" value="GAE67664"/>
        <property type="gene ID" value="JCM18909_739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5529" checksum="E7CD8F2B073DC945" modified="2014-03-19" version="1">MPERVRNSFVTCSKTMWLGHCGAEVGVMSVAMWKASLEIGCGSGIRLLDVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN2</accession>
    <name>W4THN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68445">
        <property type="protein sequence ID" value="GAE68445"/>
        <property type="gene ID" value="JCM18909_1583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="419" mass="46451" checksum="D184151BA55F71CA" modified="2014-03-19" version="1">MGESSLVRITVTAKVADGQVLPPIDDEKLQAELADATSNWDDEFITLASGIPSNRRGVDFGPEYKQEFTAKQGILDLELLNGLAEDDLGLVMYRPDDPADPSDLRLKIFNQQAPMALSQVMPHLSSLGVQIIDEHPHRIILRGREVWLFDLGLQTPGELWKVAGRCRFTEAFAASWKGECESDTFSGLVTEAGLSWSQVAMLRCIARYLRQLGSPFSQTYMARALRANPNLARDLVGIVEAKFDPTAFDDGVDAGPQRLAKVEELSESFLTDLEEVASLDHDRILRMMHAVIRAMIRTNWWQSGRRALAFKVCPTDLGFAPAPRPKFEVFVNSPRVSGTHLRFGAVARGGLRWSDRPEDFRTEVLGLVKAQMVKNSVIVPVGAKGGFVPAHLPIQRPIARNGLRKVRSATAFSCLRCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU9</accession>
    <name>W4THU9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68515">
        <property type="protein sequence ID" value="GAE68515"/>
        <property type="gene ID" value="JCM18909_1658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9226" checksum="E14CC6AB16A25174" modified="2014-03-19" version="1">MSALFVTTRKLGVMVNRAYLSLSVLALVLWVAAYRHLPGWAAGITLACIVLFSLFCEWSRVRTLARIGKSRGTAAQSSRGRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW3</accession>
    <name>W4THW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Porphobilinogen deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68013">
        <property type="protein sequence ID" value="GAE68013"/>
        <property type="gene ID" value="JCM18909_1119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Porphobil_deamC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="9289" checksum="239654F1B4D0E158" modified="2014-03-19" version="1">MLSHLEAGCAAPIGALAQLKPVSGKSPQVLTLDVVVAAVDGSRTIREQVSVELPAEVDSALAAAHTLGVTAAEELLDDGAADVADLKASGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY0</accession>
    <name>W4THY0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68550">
        <property type="protein sequence ID" value="GAE68550"/>
        <property type="gene ID" value="JCM18909_1696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="181"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="514" mass="56297" checksum="AAD585D6C2029059" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY5</accession>
    <name>W4THY5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68555">
        <property type="protein sequence ID" value="GAE68555"/>
        <property type="gene ID" value="JCM18909_1701"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16652" checksum="83A3EF8B687E95AB" modified="2014-03-19" version="1">MTVIATASNPSFSVSRVDIDRPGDTYTVDTLKDLRRERGSDVDLFFITGADALSQILTWRGADELFDLAHFIGVSRPGVPLGIKDISHLPAEKVTLLEVPAMAISSTDCRHRVSEHMPIWYLVPDGIVQYINKRGLYRDNNDKTTPEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY7</accession>
    <name>W4THY7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68391">
        <property type="protein sequence ID" value="GAE68391"/>
        <property type="gene ID" value="JCM18909_1526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="21880" checksum="538A234E59CACBAA" modified="2014-03-19" version="1">MSGSDSTVLDVALFDDPERQRQYVSGWKFSTENLVLAGMPGSGTSSTLVALALRIADTYAPGDADIVILDVFTASLDRLKKLAHVRGYAGPGNTSESRQLQKRVLRYISAELERRSAHPHDSFAPLFVLIDGFATLREGYSDVDDMSLIESFYQVWAKGPAMGIHCVATTTRLKALPPAISDLTGQKVVVSAGRHLGVSPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID8</accession>
    <name>W4TID8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Para-aminobenzoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68198">
        <property type="protein sequence ID" value="GAE68198"/>
        <property type="gene ID" value="JCM18909_1320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Anth_synt_I_N" evidence="3">
        <location>
            <begin position="236"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="2">
        <location>
            <begin position="421"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="538" mass="60032" checksum="FE2D2AF2DF30ED8F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK9</accession>
    <name>W4TIK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67959">
        <property type="protein sequence ID" value="GAE67959"/>
        <property type="gene ID" value="JCM18909_1061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5624" checksum="59652EF3B6D83868" modified="2014-03-19" version="1">MLGSAFGARTVDSPPTSMMSAPSTTRSRAWRMATSGSAHMPPSENELGVTLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL9</accession>
    <name>W4TIL9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68810">
        <property type="protein sequence ID" value="GAE68810"/>
        <property type="gene ID" value="JCM18909_1973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="5809" checksum="1E35670C1AC403C5" modified="2014-03-19" version="1">MPLSQPVLLSPDRIRLGDSELVATTLTSCLLGGGSLVLVESTDNLATIAAQEGAVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN3</accession>
    <name>W4TIN3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67989">
        <property type="protein sequence ID" value="GAE67989"/>
        <property type="gene ID" value="JCM18909_1093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7245" checksum="8420E66C40327956" modified="2014-03-19" version="1">MLTPTNAPLASLRVWCEVSAPLRRHRALTRDPEFRDQWAMWAVQEGLHIARHRPADLADLTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP0</accession>
    <name>W4TIP0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine-monophosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68397">
        <property type="protein sequence ID" value="GAE68397"/>
        <property type="gene ID" value="JCM18909_1532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS_C" evidence="2">
        <location>
            <begin position="49"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="21379" checksum="BE4F090774523DAF" modified="2014-03-19" version="1">MTGMAAESQKAGVSVVGGDTTGGPVVSIAVTVIGQTAGMAPVRRDGAVPGDEVAVIGQLGLAAAGLALLGRGFRSPRAVVAAQRCPEVPYGQGRVAAKAGVHAMIDVSDGLLADLGHIAEASGFAMDIDTAKLDITESVRTVGMATGVDPLTWVLAGGEDHALAATFAPGTVPDGWTVVGRVLPLDEASDPTVLVDGHVWQQERGWTHFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIT6</accession>
    <name>W4TIT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylmuramate-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68701">
        <property type="protein sequence ID" value="GAE68701"/>
        <property type="gene ID" value="JCM18909_1852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="1">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17842" checksum="C4E76B08A79E5712" modified="2014-03-19" version="1">MEADHLDNWGTPQAYFDGFVSMATRPEVRYVVANADDPGAAELACRLEGTGTVRVVTYGESEQAEVRLVDLDLNGPTASATLVHGPTQGRLELQVPGRYNLSNAAAAYCVGSLLGISHQDLLTGIASFTGTLRRFQLVGRVAGVSVFDDYAITRPNCAPPLVRHVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU8</accession>
    <name>W4TIU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorbitol operon transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68074">
        <property type="protein sequence ID" value="GAE68074"/>
        <property type="gene ID" value="JCM18909_1186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PRD" evidence="4">
        <location>
            <begin position="163"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="4">
        <location>
            <begin position="275"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="3">
        <location>
            <begin position="490"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="635" mass="71134" checksum="A01FD28624B6BCC8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX3</accession>
    <name>W4TIX3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-amino-4-ketopentanoate thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68472">
        <property type="protein sequence ID" value="GAE68472"/>
        <property type="gene ID" value="JCM18909_1613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7549" checksum="82ABF48C928E9AE6" modified="2014-03-19" version="1">MQWVSGFLDEEAHIGDEVTVTSIIGRRHTGILDCVNPSYSHSFGNTVPELLTIGTTHEPITSHGQEDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ9</accession>
    <name>W4TIZ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68398">
        <property type="protein sequence ID" value="GAE68398"/>
        <property type="gene ID" value="JCM18909_1533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10471" checksum="E3C190738E780F5A" modified="2014-03-19" version="1">MPDHVADSTWAIGLGEVDALEGVDLLRELADVFLVASVRARARATRRFFFAVVFRGRAGEDAQVAMPLTLSTMATTRPEVRRGVTGLVVVARDSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ12</accession>
    <name>W4TJ12_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal recognition particle, subunit Ffh SRP54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68149">
        <property type="protein sequence ID" value="GAE68149"/>
        <property type="gene ID" value="JCM18909_1268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP_SPB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9491" checksum="AEA8BDE8F81642E4" modified="2014-03-19" version="1">MKDQIENIDEREIDRIEAIICAMTPAERADVSILNGSRRARIANGSGVEVRDVNNLVNRFVDARKMMSQMGQMMGPDAGRMMVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ19</accession>
    <name>W4TJ19_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68930">
        <property type="protein sequence ID" value="GAE68930"/>
        <property type="gene ID" value="JCM18909_2105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="106"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="23089" checksum="E02FB0FCF597D89E" modified="2014-03-19" version="1">MRLLVEIEARHPEVTCPSSSPSSLYWLRSLVTGMRSKNEFDRCTNHTWPLNIGQVYTTLDRLERDGLCYRGDETPDGRVIATISPKGREEVRRWFTTPIAPATPPRNELAIKIALAATSKDVDVAALIQDQRHATMHQLQECRQARRSVAEDDLAGQLLVDGMIFAAEAEIRWLDHCESKAVQASHARPHQPVEPVTDGSKVVQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ24</accession>
    <name>W4TJ24_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-associated heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68940">
        <property type="protein sequence ID" value="GAE68940"/>
        <property type="gene ID" value="JCM18909_2115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025708">
        <property type="entry name" value="HSP15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016821">
        <property type="entry name" value="HSP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13640" checksum="C81733F416F5F46C" modified="2014-03-19" version="1">MTRIDVWLWSVRVYKSRSLATAAVKGGHIRLNGDPVKPSHDVKPGDTVTIHTPGWDRALKVVNPITKRVGAKLAVEAYEDLSAPRPAYLSAPLARRDRGAGRPTKKDRREIDRLRGRDFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ43</accession>
    <name>W4TJ43_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein Obg</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68562">
        <property type="protein sequence ID" value="GAE68562"/>
        <property type="gene ID" value="JCM18909_1709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8333" checksum="C7B174E282773F60" modified="2014-03-19" version="1">MLELKVVADIGLVGFPSAGKSSLIAAVSRAKPKIADYPFTTLVPNLGVVVAGETTYTVADVPGLIPGASLGKGLGFDFFASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ60</accession>
    <name>W4TJ60_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-dehydroquinate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68826">
        <property type="protein sequence ID" value="GAE68826"/>
        <property type="gene ID" value="JCM18909_1990"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5415" checksum="92003CFA26AF7460" modified="2014-03-19" version="1">MAPCIEVHISNIAAREEFRHHSVVSVHVTGTIAGLGLKGYELALSWLATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG7</accession>
    <name>W4TJG7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68906">
        <property type="protein sequence ID" value="GAE68906"/>
        <property type="gene ID" value="JCM18909_2078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12640" checksum="BA18A3BE68BF7B15" modified="2014-03-19" version="1">MDTTATIGWGIAGTGRIARTVLKDFAHVPRARICAIASRSAARADAFADLVTQNLSCPRPDAHDSYVDMITNPTVNVVYVATPHPQHRPITLAAIDSGKAVLVENSLRRNCPCGCRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH4</accession>
    <name>W4TJH4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydropyrimidine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68304">
        <property type="protein sequence ID" value="GAE68304"/>
        <property type="gene ID" value="JCM18909_1432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="2">
        <location>
            <begin position="37"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="284" mass="30235" checksum="543597FA78BE8E0B" modified="2014-03-19" version="1">MRHEEARQAETELEYMDSFAESLSFFPTVASNEGGITERYLAHLEASANAVGIPVIASLNGATNGGWVDTAKRMEDAGAAGIECNIYMVPGDLEQSAEEVEDRHVEIVQAVKDAVSVPVAVKLSPFFSALGNMATRLDAAGADALVVFNRFLQPDINVETMQVEPGVWLSSPADARLPLTWIAALSGRIGASLAASSGVESTDDVVKYLLAGADVVMTTSALVRHGAGYATELQKGLESYLQRKEVDLDTLRGMLAVPNDASTAEYERNGYVAALEKAKTTYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL9</accession>
    <name>W4TJL9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68966">
        <property type="protein sequence ID" value="GAE68966"/>
        <property type="gene ID" value="JCM18909_2144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="22224" checksum="DE05D2C5E38C9C05" modified="2014-03-19" version="1">MSNEALNTVLSHLVIPVVVIHDAATTPAVTDGLVVGGLPVAEVTFRTDAAPAAIESMAGDGRITVGAGTVINARQVDEAVSAGASFVVSPGLSREVVDRCRHHAIPVLPGVITPTEIMAGIDMGLDTFKFFPTGTFGGAATIASLEGPFPHLRFVPTGGVKPHNLTDFLSRANIPAVGGTWLTPTDAVAARDCHTIANLVREAVDSAHHIVKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ1</accession>
    <name>W4TJQ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69006">
        <property type="protein sequence ID" value="GAE69006"/>
        <property type="gene ID" value="JCM18909_2185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14342" checksum="BD46AF3310860C56" modified="2014-03-19" version="1">MDDFLCDSATPSEAETRLRCLFTIQVTNQLVAGPFTVDEDGYTASVGDKDLDLTYTEFELLKYLVGHPGRVLTRDLLLSDVWGYDYYGGTRTVDVHIRRLRAKVGPEYEGHIQTVRSVGYRFQAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW8</accession>
    <name>W4TJW8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="4">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rlpA</name>
        <name evidence="8" type="ORF">JCM18909_2451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the RlpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69255">
        <property type="protein sequence ID" value="GAE69255"/>
        <property type="gene ID" value="JCM18909_2451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009993196" description="Probable endolytic peptidoglycan transglycosylase RlpA" evidence="4">
        <location>
            <begin position="27"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="7">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="386" mass="39988" checksum="87FE8FA0CD0ECBCC" modified="2014-03-19" version="1" precursor="true">MSKVVASAIAGALSLTSAGGLTMVQALDRDTVTFSVDGVSQQAKVKPGTVKQALAQQGITVGPHDDVQPSLDSEIHDGQVITVNYGRRVVVTIDGKKVVRWTTAKNVAEVLAQLNQSDPDNLVSVSRSLDISRAGLSFSMQTAKDVTVTIGGKAQKVTAVGTVADALKAAKVEVDSSDVVNPGLGTPLADGMKITLTMVDQKSQKRRVAVPFSTKKVEDSSLPKGEIKVITKGVNGINEETWTVVFKDGKKVSEKKVSSKVVNAPVTQVIKVGTKTASSSSPSTRSSSDPVTRGITCLASTYGEGDGTAGGPTASGETFDPSAFTAASKTLPLGSTIRVTNVSNGRTVTVRINDRGPYVGGRCLDLSTAAMNAIAPGQGLVTVRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK01</accession>
    <name>W4TK01_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-carboxyhexanoate--CoA ligase</fullName>
            <ecNumber evidence="5">6.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + CoA + heptanedioate = 6-carboxyhexanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14781"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57360"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate metabolism; pimeloyl-CoA biosynthesis; pimeloyl-CoA from pimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.14" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69126">
        <property type="protein sequence ID" value="GAE69126"/>
        <property type="gene ID" value="JCM18909_2314"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00999">
        <property type="reaction ID" value="UER00351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042410">
        <property type="term" value="F:6-carboxyhexanoate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005499">
        <property type="entry name" value="BioW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03744">
        <property type="entry name" value="BioW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="333" mass="35697" checksum="B084B693DBA32C63" modified="2014-03-19" version="1">MVFNYYPVANVEESPMSSQNPTTVAWWSVRMRATGTLDGEPYHVSGVESLVAPGMIEQTVAGLTQRALAPGHTVKARQVRVSLDQLDVKPTVIPALPTELKECPDPVAARQYFVDVLSRFVPHPAEALRVLTEGPTMRGAAMVEAGTGRRLEADPLRGVRVTKFGDLTESAPGTSLAHKKHHHEAVLLASKVAAAPGVLAELCISDDPHYTRGYVCADGVYTTVTNVKADGDPNGGRVILVDTTRADPTTITAWLENHPVLIGPATASGPKATSWHDHLCGRLNAWRAAGLERRPRTFCSAQDPDAITTDGPALLFSSSDYLGLSTEPKVQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK47</accession>
    <name>W4TK47_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68499">
        <property type="protein sequence ID" value="GAE68499"/>
        <property type="gene ID" value="JCM18909_1641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="4">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24320" checksum="971263FB72DEB86C" modified="2014-03-19" version="1">MRIEKDSMGEVEVPAEHYWGAQTQRSLHNFEIGRDTFVWGRDMIRALGTLKKSAALANKELGELPGDVADLIVQAADEVIAGKLDDEFPLVVFQTGSGTQSNMNTNEVISNRAIELAGGERGSKKPVHPNDHVNRGQSSNDTFPTAMHIAVVCALNERLYPAVQQLRDTLDEKAKKKYDDVVMVGRTHLQDATPIRLGQVISAGSPKSISPSTASATPIHAPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK70</accession>
    <name>W4TK70_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69350">
        <property type="protein sequence ID" value="GAE69350"/>
        <property type="gene ID" value="JCM18909_2557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24825" checksum="FABF9A5DD49411CF" modified="2014-03-19" version="1">MRVDDDLSTASTADLGQVVHRFKKTWHIYGPVPITVDMRENFELELRSNGGVARIVRDSPLRGQADRSVARGDTVRILPGVVAATGAARHVTTVIQALKLWHRDATLVGMAALVLLGLKNPVTQRRWDYTGIQAIEAFSPTRRLRRPRIWVHRWHVPHHFTIEEEGIRVAIPEVSVIILAIQGQWDWVCQALRQHLVTPAHAGRPVKPSPAGTRRPKSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA5</accession>
    <name>W4TKA5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68942">
        <property type="protein sequence ID" value="GAE68942"/>
        <property type="gene ID" value="JCM18909_2117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12359" checksum="7EC62A6F17024495" modified="2014-03-19" version="1">MCSADAMALSEALTTAADMVDYLAEQARLENKRRQQVRDFAAQHDDFGDHVRDFFTGVDVPPNLTPAEPPSPQLLHPPVTGDRQQDRSIRGSSVECLRRTPRNSPVRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC5</accession>
    <name>W4TKC5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68883">
        <property type="protein sequence ID" value="GAE68883"/>
        <property type="gene ID" value="JCM18909_2054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="115"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="257" mass="27184" checksum="D6093B42803C6EE9" modified="2014-03-19" version="1">MSDIDVTGTLLPAMIMAAIAAWLFVPATARTRTQGRKPPPAWLAPRPGAPASRIRVLAGLVAACAVLVGVPWPFPAAAGLSVLVGAVMWWGSGRLESSGHRRMEQRRAAQLPEALLMLSSAMEAGLPLRSAVTTVAESLEGPCAEDLRRLASSLAAGVPDSRAWNDLASVEVWRDPAQDVSRAVNSGEGISKLLSAHAAQLQVAAAEKAEKKRHVRRELTPSVRWCAATFQPFFVGWGGADYRRNGVGGAVTTRAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH5</accession>
    <name>W4TKH5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69301">
        <property type="protein sequence ID" value="GAE69301"/>
        <property type="gene ID" value="JCM18909_2502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="313" mass="33119" checksum="D5E2814906589A72" modified="2014-03-19" version="1">MTSSIFTGLSAFPLTPLHDDKVDEEAFADLITRLVVAGVDSITVLGSTGSYAYLTPSERARIAELAVEHAGSTPVFVGVGDLRTSHVLAHVEAAEQAGAAGLLLAPMTYQALTADDVFELYCTVTEHTGLPIIVYDNPSTTHFTFTIDLYTRVAELSGIASVKIPGVPADPDKAREYVKTLRAVVPKHVTIGVSGDAFAATGLNAGCDAWYSVIGGTCPGPALTITRAAQEGRATDAMAESEHLAPLWELFVAFEGSLRVTAAIAEHLQLVPDRYLPLPIQGLTEVQRARVAQVVGELGLASPEITPRPTRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI4</accession>
    <name>W4TKI4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitrate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69037">
        <property type="protein sequence ID" value="GAE69037"/>
        <property type="gene ID" value="JCM18909_2219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="414" mass="44844" checksum="6A0EA9F46086EC23" modified="2014-03-19" version="1">MANFDHFDVLHDHRVLRMVLGECNRTQTQRHRIPPDEVTAVLAHRHARTLGRLHPPGLHVPTAGDRHSQARGIQLPALPHPYAGWFFAVQNTSTGYGTLLLLAFLCGVGGGSFSGYMPSTGYFFPKSKQGTALGVQAGIGNLGMSIVQLLGPWLMGFGLLGLTWIAPQHTAGSPLWVHNIAIVFVPWTILATILAFTMLKDVPVKANFRRQIDIFTNPDTWIMTLMYVMTFGLFSGFSAQFGLLIENTYGNSSNLAHGFSNLPTGASYAFLGPLIGSLVRVIWGPLCDRFGGAIWTLVSGIGMALTFGVCAFFLNPTSPSQFGYFLWGMLIMFFFSGIGNAGTFKQMPMIMPARQAGGAIGFTAAIGCFGPFVVGVALSSMSAVAWFWICTVFCIVCSIICWIRYARPGAPCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN1</accession>
    <name>W4TKN1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69087">
        <property type="protein sequence ID" value="GAE69087"/>
        <property type="gene ID" value="JCM18909_2271"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_C" evidence="9">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="281" mass="30314" checksum="C4EF6CC62721E114" modified="2014-03-19" version="1">MMNILNGGAHADSDVDIQEFMIAPIGAESFKQAYEWGAAVYHSLKKVLKDKGLATGLGDEGGFAPNLPSNAAALDLILDAIKAAGFEPGKDVALALDVAASEFFEDGKYTFEGQAKTSAEMIEYYEGLIAKYPLVSIEDPLDEEDWDGWAEFTRKLGEKIQIVGDDLFVTNPKRLAKGIETKAANALLVKVNQIGSLSETIDAVELAHRNGYRCMMSHRSGETEDTTIADLAVALSTGQIKSGAPARGERIAKYNQLLRIEEELGDSAEYAGASAFPRFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX2</accession>
    <name>W4TKX2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69083">
        <property type="protein sequence ID" value="GAE69083"/>
        <property type="gene ID" value="JCM18909_2267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849292" evidence="1">
        <location>
            <begin position="32"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18136" checksum="217977199861C9FA" modified="2014-03-19" version="1">MMTMRRRLGAAAVAVVLVSVASGCASSPSNAATVGNTTVTMKSVDDAVEHCSKFINPSSELTPRQIIASTVIRGAVAQEVLDKRGAKLSDAERDQIVARNGMAALDSDQVCHTMVRSFAGVFHLFDLEGDRKAKADLSAVDVKANPRLGSWDANNLVVQGSSSLSQPFTKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY5</accession>
    <name>W4TKY5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68824">
        <property type="protein sequence ID" value="GAE68824"/>
        <property type="gene ID" value="JCM18909_1988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6684" checksum="88A6367BE9B022C7" modified="2014-03-19" version="1">MAAKIAVDPTDSAFEVARIIDNAEASVRAAEPLVGPLFLEPDIRYGDKRIKDGEERPEDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL98</accession>
    <name>W4TL98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69755">
        <property type="protein sequence ID" value="GAE69755"/>
        <property type="gene ID" value="JCM18909_3006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="280" mass="30105" checksum="B86FE494873E614C" modified="2014-03-19" version="1">MMTQVTSKPRTATRTIKADATIAKAVDQAREAAEYRAGDFGVGEHVGTIAEGERVLTHLFECPHPGYRGWRWAVTMSRALRGRNVTVNEVVLVPGEDSLLAPPWVPWRDRVRAGDIAAGTLMPTADNDPRLEPGYTGGELAADEDPAEWAATRAVASELGLGRERLLSREGRDSTAERWLAGEGGPGNATSHHAPASCVTCGYFVRLQHSLGRVFLGCARTSTLPPTVRWSTSTMVAAATPTLLRSVGGLSSQSPFSTPSRLTSRCSTESRLLRRGAGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA7</accession>
    <name>W4TLA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68929">
        <property type="protein sequence ID" value="GAE68929"/>
        <property type="gene ID" value="JCM18909_2104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="21821" checksum="DE58A630FAF00EAD" modified="2014-03-19" version="1">MTSPPSRAADQITPTVQRTVLSLDHVSRSFGEGEQRVDAIVDVSLGVNPGTFAAVMGPSGSGKSTLLGLAGGLDQPTSGTVPVCGEPLGGMSRDDLARVRRRQLGFVFQDYNLVPTLTAVENVSVPLELDGVSATRARKAAEIALDRVGVPELVDRHIEKMSGGQRQRVAIARGIVGDRRVLLADEPPALLTRSPATKSWPHPDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF8</accession>
    <name>W4TLF8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69273">
        <property type="protein sequence ID" value="GAE69273"/>
        <property type="gene ID" value="JCM18909_2473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="174" mass="19157" checksum="AC93A9C68B85E74C" modified="2014-03-19" version="1">MNMSDDILKAFNDQITLELTADMTYRQLAIEADSQDLSGMAAWLRHQADEEIVHANKFIDHTLDRGSHPRIGTIEAPEVEAGLSALEIFQAALAHEEKVSEAIRELYRACTSAGDIDAIPLLQWFINEQIEEEATVGEIVGRIELIGDDGPGLLRLDAELGSRNAESTENEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM3</accession>
    <name>W4TLM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69069">
        <property type="protein sequence ID" value="GAE69069"/>
        <property type="gene ID" value="JCM18909_2252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849307" evidence="1">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="198" mass="21564" checksum="9F6CE303019ECFF9" modified="2014-03-19" version="1">MLRRAVVGAVTAAVASTTVLSAVPAGAVQESPNNGINFELPQRWNDNYKPGTRCTPQGTRGVYVTASRRWFKQTDGASVENTTDTAMPVTHTVTVKRSETTEVKGEIKADGTLNTYLNQSYGFDYINTVSWELSQKVGPYDLAPHTQGRLVWGFIMLDVDAQNVSCGADLTWHAVGKPFSGTNPESRYAELRFEGSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLQ7</accession>
    <name>W4TLQ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69686">
        <property type="protein sequence ID" value="GAE69686"/>
        <property type="gene ID" value="JCM18909_2935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6952" checksum="0FF538A6C7D5D15D" modified="2014-03-19" version="1">MWTASQGGTGLWIDTHNDSSALAEAAKRVGVRLAPGPGYSAYDGQRTMLRLPVWHEPESLEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR5</accession>
    <name>W4TLR5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ORF">JCM18909_2662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69447">
        <property type="protein sequence ID" value="GAE69447"/>
        <property type="gene ID" value="JCM18909_2662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17082" checksum="3DAF508F2BE676A3" modified="2014-03-19" version="1">MIDITNESGSPSNEEGLVGLATFALDWLRIHPSSELSIILVDEQTMEAYHEKFMGLPGPTDVLSFPMDEMRAPGDDEDPPSGLLGDIVLCPTVTARQAAENGRTPDGEAEYLLIHGLLHLLGHDHAEPGEKRVMFRLNDEIIAAWDDHREQAGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX0</accession>
    <name>W4TLX0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69965">
        <property type="protein sequence ID" value="GAE69965"/>
        <property type="gene ID" value="JCM18909_3240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="311" mass="33147" checksum="BF620387ACD3C056" modified="2014-03-19" version="1">MALACLLARNMPFLGRHLLVADDALTICLAGVVICAVGVVDDLLDLPALAKAAGQVLAAGIVVTGGVRMFWIPLPNSIIALGTPTSILVTVFFIVLCANAVNFIDGLDGLASGVVAIGSLAFFSYTYLLAHEQDFVVATTTSLITAATAGACLGFLPHNWHPARMFMGDSGALLLGLLLATSTISLTGQIDSTALTARGGGLVPAYLPIVVPLMVLAIPFLDLVMGYIRRTWRGTWFFVADKQHLHHRLLQRGHSHMWAVLLMYLWTTVLTFGTVFIGLEQTWWAVVIVMTGLGMCVLLTMANSHHPAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ8</accession>
    <name>W4TLZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70000">
        <property type="protein sequence ID" value="GAE70000"/>
        <property type="gene ID" value="JCM18909_3278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5486" checksum="130F13BED03321D7" modified="2014-03-19" version="1">MSRWWTHGAVAVRSDVVAAVVVSADGFFPVLGSIATGDTDLGAAGKPSFHELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM05</accession>
    <name>W4TM05_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein 22.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69776">
        <property type="protein sequence ID" value="GAE69776"/>
        <property type="gene ID" value="JCM18909_3028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017585">
        <property type="entry name" value="Flag_basal_body_FlgA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13144">
        <property type="entry name" value="ChapFlgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SAF" evidence="1">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="166" mass="16575" checksum="3A7C7881143BC64D" modified="2014-03-19" version="1">MATSSSGREVIVAAHTIEGGRVIQRSDLHTVRIDPGVLPHETATLAQVEGRQASVRITEGTILTSSAVLSGTAVGSGKALVGIHLADSSMVGMLQVGQRVSVVSPSEDGTPHVLTRGAIIRSLPTSGGGLIQGSPSTELVVVSTGSADAAAIAVAGQGQPLGLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM23</accession>
    <name>W4TM23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69244">
        <property type="protein sequence ID" value="GAE69244"/>
        <property type="gene ID" value="JCM18909_2440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="6912" checksum="DF4E1963BB5A1B77" modified="2014-03-19" version="1">MLATAGCWAGRTWLAKSGPTIAGLLGATYLAAFGSSHGLAKKIGAWPAVITVTAATCTACHFLCDTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM85</accession>
    <name>W4TM85_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69304">
        <property type="protein sequence ID" value="GAE69304"/>
        <property type="gene ID" value="JCM18909_2505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9288" checksum="466C7572838D3B5C" modified="2014-03-19" version="1">MSTPLITPELVSLDANLGSTKTEVITSVAGLMLPLDAPTLTASPTTLWTASPKARPVCPVGSPSPLPLSRGISGIPGVRPAVARCRLQWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB0</accession>
    <name>W4TMB0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70120">
        <property type="protein sequence ID" value="GAE70120"/>
        <property type="gene ID" value="JCM18909_3411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR_1" evidence="6">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15168" checksum="66DDA92B81E4AE12" modified="2014-03-19" version="1">MVQTTGDTGPYLQYAHARVSQILRKAAAEANPNVDPEADLDAMDWGRISVLDKPAEQQLALLLSRFGEIVEVVATDLTPHKLCTYLYELAGAYSVFYEQCPVLRSTGEVRGSRLALCAATCRVLGRGLDLLGIDAPDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG1</accession>
    <name>W4TMG1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69603">
        <property type="protein sequence ID" value="GAE69603"/>
        <property type="gene ID" value="JCM18909_2840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17333" checksum="1F82FBD1080AB725" modified="2014-03-19" version="1">MNIALAIVQFLVNEILSVPAFLIGIITAVGLAAMRKSVGQIAGAAIKATLGFLLIEAGAGLVVNSLGPLGKMIEGALGAQASYPPMRRSLASPNNNLDPRSHGSCSRGFSSRWYWPASPHFTTCSSPGITCCSWRPSSPSSWHRHRCPLPSSSGLAHCCWGCLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML2</accession>
    <name>W4TML2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Substrate-specific component BioY of biotin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BioY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69941">
        <property type="protein sequence ID" value="GAE69941"/>
        <property type="gene ID" value="JCM18909_3211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="13359" checksum="52794F903567B07B" modified="2014-03-19" version="1">MSSRNGFQATDLALIAVFAALVAVLAVIPPMFMVGAVPFALQMVAVMLAPMVLGSIRGGCAVSLYILVGALGLPVFSGGSSGIGVLVGPTGGYLWGWLIGAFVAGAVATSVLRRRPRKSMLPVWLFLSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR9</accession>
    <name>W4TMR9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69837">
        <property type="protein sequence ID" value="GAE69837"/>
        <property type="gene ID" value="JCM18909_3093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="31116" checksum="63CC4BB5AB598408" modified="2014-03-19" version="1">MVKEQRPCIIGNVAISTTLHLAPNDIGAFTDTDELRILMESAQSHGYFNPPPLENREYLIEEPIGVVVSDTSQPEYLTLRLDSHPEHHILGRPGMKIMLVLADALRLIGLSTPQSIDVECVYFNPRDWDLLNPDPDDHIHMIGTLSREVCRWMSPHLTHTWHATATTNPDLDPHLAQNTINRWFPPDFEYPWLGHTPQAHQETLTWHMPDDITALGWLFDLITLLQGQPPQHIHATPNEQKKSDPGEPITNTDINQGTRISPARSQVPHISSHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS9</accession>
    <name>W4TMS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiaminase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69847">
        <property type="protein sequence ID" value="GAE69847"/>
        <property type="gene ID" value="JCM18909_3106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026285">
        <property type="entry name" value="TenA_E"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003170">
        <property type="entry name" value="Pet18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR003170-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="16177" checksum="3C94744CF78912ED" modified="2014-03-19" version="1">MICSEESGWFEATFDELGVSQADRAHPQLSEPTRAFENLMHEAVNTHHYPTVLVLLVVAEGLYLDWASRTDAPEPGANLPNKYLGWVDLHRGDEFRTWVQFLVDELERASGQVDLEELTRFWNAAVDLELAFFNDVPFPLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU5</accession>
    <name>W4TMU5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inosose dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69738">
        <property type="protein sequence ID" value="GAE69738"/>
        <property type="gene ID" value="JCM18909_2987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="204" mass="22320" checksum="11C1532BD981D863" modified="2014-03-19" version="1">MVNKELDAFEAAGGDYLILATDSGRDGYDDRPVLDEAGWKTLFTNLDQIREICASRNVTACLHPHWGTMVQNRDEVIRVLENSSIGLCLDTGHLACGGTDVVELVRKYADRVDIVHAKDVHKEIADKLLPGEITWSEGIRAGMFAPIGDGDIDFAAIVRLLDEAGFDGYYVLEQDIMIDEEPPAGDGPIINAKKSYEALASLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW9</accession>
    <name>W4TMW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kup system potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69534">
        <property type="protein sequence ID" value="GAE69534"/>
        <property type="gene ID" value="JCM18909_2760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="24201" checksum="8762126B3823E4BC" modified="2014-03-19" version="1">MKIASGGWIPLLFATIVVIIMTTWRRGTAYIAKQRQDDEGPLDDFLNWMHETKPTRVPGLAVYPHPGRATTPLALLNNLRFNHVLHEHNIIISIVVENVPHVRHVNRIEKVNLGRPTDGITYIACHVGFTDSQDVPKALALAAAKCPFLKDHLDEAIYYLSLVDVKRDEPQQGAHMAGWRKMLYIAMSRNQADRTRVFRIPRTRAVVMGEAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX8</accession>
    <name>W4TMX8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69768">
        <property type="protein sequence ID" value="GAE69768"/>
        <property type="gene ID" value="JCM18909_3019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13359" checksum="9D99132DCEAFC393" modified="2014-03-19" version="1">MATVALTKDNFSSTIDSNDVVLIDFWASWCGPCQRFSPIYEDASGRHSDVTFAKVDTEDQQELSAGLEITSIPTIMAFRAGYLVFRQSGLLQGRQLDGLIEKVKEIDVEDLKKQAAAQNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN02</accession>
    <name>W4TN02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69793">
        <property type="protein sequence ID" value="GAE69793"/>
        <property type="gene ID" value="JCM18909_3048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="6">
        <location>
            <begin position="530"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="824"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="876" mass="97242" checksum="16B7000878C978EA" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN20</accession>
    <name>W4TN20_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF3817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70126">
        <property type="protein sequence ID" value="GAE70126"/>
        <property type="gene ID" value="JCM18909_3422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8544" checksum="A5FEAEC79297E1C8" modified="2014-03-19" version="1">MVNVVGISHGWLYPVLLITAYLLGRKAGWPLTRLLIIALAGTVPFLSFVAEYFARKDVNRRIDDAKKLLGSSWRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN73</accession>
    <name>W4TN73_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosylamine-glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70405">
        <property type="protein sequence ID" value="GAE70405"/>
        <property type="gene ID" value="JCM18909_3723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GARS_A" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7323" checksum="72F5A3DDAAD10811" modified="2014-03-19" version="1">MGAYTPLPWAPDDLVETVSTTIISPALRAMADRGTPFVGLLYVGLALTSAGPKVVEFNVRFGDPETEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN85</accession>
    <name>W4TN85_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="ORF">JCM18909_3138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69873">
        <property type="protein sequence ID" value="GAE69873"/>
        <property type="gene ID" value="JCM18909_3138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24440" checksum="7B8892D678F0769C" modified="2014-03-19" version="1">MITGRRLLMTQSATDIYQPRRSAMRKHTPNDQPPLGGSVQRWVSASGDTMGESVLHAQTRPVTEFDEDLTTLVRDMFATMNAADGVGLAATQVGVDLSLFVYICPDANNVVHHGAFCNPVVTLPEGHDRHLEAADEGCLSWPGGFQSMARPDLATCTGQDPWGNVITVTGTGFFARCLQHETDHCNGIVFGDRLSKRARRKLDEQHDSVAHLYPDDWPLTPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM5</accession>
    <name>W4TNM5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70336">
        <property type="protein sequence ID" value="GAE70336"/>
        <property type="gene ID" value="JCM18909_3650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="6883" checksum="D11FFB8A64BADCAC" modified="2014-03-19" version="1">MGVTVILIIPVVLMAALLGGRLVRQRSQRIAGGIVGAVTVLVGAGGLYASSWTCLRWWRSHGQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU4</accession>
    <name>W4TNU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of membrane protease YbbK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69879">
        <property type="protein sequence ID" value="GAE69879"/>
        <property type="gene ID" value="JCM18909_3144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="59"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16170" checksum="3008C03759959061" modified="2014-03-19" version="1">MLEPFQEHCWLLWAVASAVLACAEMLGGDFTLLMLAAGAGAGAVTAAIVPGLWLLQVIVAVAVAALLLAVLRPTLLRRVREAPGYRSSLDKLVGSEGVATSEITDGHGQVKVDGEEWSARALEPGSTIAVGERIEVYEVDGATLVVYPVFGILGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP10</accession>
    <name>W4TP10_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide methionine sulfoxide reductase MsrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70277">
        <property type="protein sequence ID" value="GAE70277"/>
        <property type="gene ID" value="JCM18909_3584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6745" checksum="D7106CB0D07037FF" modified="2014-03-19" version="1">MNKTEMVSPENALPGGHTPVLAMPFFHRVTGDRLDRLFPGSETIYLAMGCFLGSRKAVLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP82</accession>
    <name>W4TP82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70337">
        <property type="protein sequence ID" value="GAE70337"/>
        <property type="gene ID" value="JCM18909_3651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="13916" checksum="84CF707F678005EF" modified="2014-03-19" version="1">MWLMTQQHTSTIPSAPKALTISAWVAVGAVIVQAVLACFMLSGVHGLGDAHMGFGIVTLLAAIVAAVLAVMWKRRGGSSAVVGHAVGMAVLILVQYVLGELSNGGVIKWIHVVLGVVIVIGLLVLPQSIGKNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP88</accession>
    <name>W4TP88_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylalanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70223">
        <property type="protein sequence ID" value="GAE70223"/>
        <property type="gene ID" value="JCM18909_3521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3_4" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9473" checksum="AE9DD57D640470BD" modified="2014-03-19" version="1">MTVARAYRRHKLGSEASRRFERGVDPICAHTAAVRAAELLAQYGGATVGEPTVVGEVPEMPRQTINADLPNRILARRCQLKRSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPA1</accession>
    <name>W4TPA1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70029">
        <property type="protein sequence ID" value="GAE70029"/>
        <property type="gene ID" value="JCM18909_3309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="3">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="312" mass="34265" checksum="C6FA69367090AF88" modified="2014-03-19" version="1">MGDDPVRVGVLGVEQIRGIQSRGVAATAKHFPGHGDTQIDSHLGLPVVEYGRTTLERHLVPFRMAMSAGVDMIMTAHIIVKALDPTMPATLSKKVLTGLLREQMGYRGIITTDALDMEGAQLAVMTEDEKSTYIRLKAAADAEGNDPTAADEGHASAEFNAFMKPIRGRVAVQAFEAGSDILLNPHDADAVVTAMRRAIADGRVSERRLDESVLRILSWKRRRRITGRPVDLAAADREVRSGRKVADDIAARSVTMLVNDGTLPLKPSRVLVTGTRRVIRSTSSSRCAWPDSPRFLFRQPGRNRRQPMSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPB4</accession>
    <name>W4TPB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70367">
        <property type="protein sequence ID" value="GAE70367"/>
        <property type="gene ID" value="JCM18909_3683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23112" checksum="AAC16CB2AB674185" modified="2014-03-19" version="1">MKALAAAHGQRSRVKPLIERWELAPFAGTKVGKCSGGQRQRLRFALAMLPNPDVLILDEPTTGLDVEARRRFWQVMGEEADAGRTVIFATHYIEEADSFARRVVLVSGGQLVADGPINEVRASVSGSTVRAALTDPSGLAEDLHTFPGINDITVQGQQLIVHTSQPDDLARHLLTHTDAHGLLISTTTLEDAFVRLTGPNDSRDDVDDWEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPE1</accession>
    <name>W4TPE1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_3585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70278">
        <property type="protein sequence ID" value="GAE70278"/>
        <property type="gene ID" value="JCM18909_3585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="PTHR11616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE70278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29551" checksum="8ABDD21A6CFCB901" modified="2014-03-19" version="1">MSDPAQSGATVAGGGRATRKPQRRENFVGRGAFLIAAIGSAVGLGNIWRFPYVAYSNGGGAFIVPYLVALITAGIPLLFLDYAVGHKFRGSPPMALRRLHKRMEAIGWWQTLICWVIVIYYAVIIAWAIRYVGFSVTKTWGHDPEGFLTGSFLHVASNVDVKFHFVSGVFWPLLLLWLCVLAIMAAGVEKGITRALWIFMPLLAVMFITLVIVALTFDGASVGLNALFTPSWGALGNYQVWMAAYGQIFFSLSVGFGIMVTYAPTSSRSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPE8</accession>
    <name>W4TPE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70079">
        <property type="protein sequence ID" value="GAE70079"/>
        <property type="gene ID" value="JCM18909_3365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007737">
        <property type="entry name" value="Mga_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05043">
        <property type="entry name" value="Mga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH_11" evidence="4">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Mga" evidence="3">
        <location>
            <begin position="90"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19377" checksum="424D3110F0C8E67C" modified="2014-03-19" version="1">MFSVDSFSQRQALLLQLLSEVDHPIKGTDLAGLLGVSTRTLRYDIARINGISRDNIIESTTNGYSVEQSVYTGVVARNSEFSTQLEHHERILLYLFDTPDTTIYDVMRDCYLSESVIKASLKRLKPQFEDHSLHLSLRGSSIHLDGSEVYFRNFLGSLVNTAMDAVVGRMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPF9</accession>
    <name>W4TPF9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleic-acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70611">
        <property type="protein sequence ID" value="GAE70611"/>
        <property type="gene ID" value="JCM18909_3965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9004" checksum="A15093A0C1D66050" modified="2014-03-19" version="1">MTTRPQRTCVGCRHVDDPANMARYVLVDGVVVADPTGHAQGRGAHVHVDDECWKRAVSGGFARSFRARVVVRSACQERLSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPJ5</accession>
    <name>W4TPJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70656">
        <property type="protein sequence ID" value="GAE70656"/>
        <property type="gene ID" value="JCM18909_4024"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase_3" evidence="1">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12093" checksum="0A477268667EA33B" modified="2014-03-19" version="1">MLHIWTQPDGNTYPITGFENHGGWTELGSDAKPLAAVESGWGNGNRRDEGAVQGRVIGTYPHGPVLVRNPQLADHVLEMALGRRLEPLDIPEMTALRQRRIEAVRTDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPT6</accession>
    <name>W4TPT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosomal replication initiator protein DnaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70542">
        <property type="protein sequence ID" value="GAE70542"/>
        <property type="gene ID" value="JCM18909_3882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_DnaA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="108" mass="12421" checksum="FA4BAE4C67EE435B" modified="2014-03-19" version="1">MTSSFLQSKIQTQEEFFHTFNTLHNAQKQIVMTSDRPPKLLEALEPRLRSRFEWGLLTDIQPPDLETRIAILRRKVAAEKITVEPDVLEFIASRIQTNIRELEGASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPZ5</accession>
    <name>W4TPZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lead, cadmium, zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70607">
        <property type="protein sequence ID" value="GAE70607"/>
        <property type="gene ID" value="JCM18909_3958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4110" checksum="8E29A76408EA6417" modified="2014-03-19" version="1">MVGVGRGGQLGILIKGPEALEASGRIDTVVLDKTGTVTSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQC3</accession>
    <name>W4TQC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70419">
        <property type="protein sequence ID" value="GAE70419"/>
        <property type="gene ID" value="JCM18909_3737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="9918" checksum="53D3195BBBB32D6D" modified="2014-03-19" version="1">MRAAHELAHSTVTGLRQTELTDADSPVVGLLGGVMKSQLIHAAITREITAAMPGARIVEPLGEGLDGAAALPTVSPESPARPAHPRRPVSHNTAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQH0</accession>
    <name>W4TQH0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maltose/maltodextrin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_4021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70653">
        <property type="protein sequence ID" value="GAE70653"/>
        <property type="gene ID" value="JCM18909_4021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37538" checksum="64EBBC2C7699C338" modified="2014-03-19" version="1">MTTATVEQTNKRSSRAKSQERLALALIAPTLIVLTIVIVIPVIQSVKQALYGQPGLDPETGFVNETEPFVGMKNFADIFTGSGERFWTAFWNTTLFGVVTVVLETVLGVIMALIMHRAMAGRGIVRAAILVPWAIPTAVSAILWGWIFNQNGVANAIIGTHIMWASGNWTAKWSIIIADVWKTAPYIGLLTLAGLQVIPTEVYEAAKVDGANAWKRFVSITLPLVKPALVVAVLFRALDALRMFDLPFILVGPRMKSVETLSMLVQDEASNLRYGAAAAYAIILFLYVFIIAFAFIKILGADLVGDEHKHKKMKATTFVSGGRPGGRRARQKANAVQAAASKEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQI8</accession>
    <name>W4TQI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70494">
        <property type="protein sequence ID" value="GAE70494"/>
        <property type="gene ID" value="JCM18909_3821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="259" mass="27166" checksum="4C36132954D12099" modified="2014-03-19" version="1">MTRYCGPDLARVGAGLPVAAYCDEITTALHGGRAVIVAPPGTGKTTFVPPLVASRCSGRVIVTQPRRVAARAAARRLATLTGTRPGEFASHTVHGESTTTRDTKVEFVTTGVLLRRLLSDPDLTGVDAVVLDEVHERHLDADLVVAMVCEVAQLRDDLTIVAMSATVDSSGWAAFLGGVEPAPVVEVAFALHELEVEWAPAAGAAVESRGVSREFLGHLGTVTVDALDRHTEGSALVFLFRAPARLTTSSRICVPGSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQY8</accession>
    <name>W4TQY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ChlI component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000061">
        <property type="protein sequence ID" value="GAE70659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70659">
        <property type="protein sequence ID" value="GAE70659"/>
        <property type="gene ID" value="JCM18909_4030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mg_chelatase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12481" checksum="445F6C40E60BE026" modified="2014-03-19" version="1">MRTLALGTTEDRLVGGLDLEATLVAGRPVLQPGLLSEVDGGVLYIDEVNFLDDHLVDLVIDACAGIVRVEREGLTASLPSRFVLVGTMNRGGGTASAVVGPVRTVHRRARRVRPGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDQ9</accession>
    <name>W4TDQ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonucleotide reductase transcriptional regulator NrdR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67090">
        <property type="protein sequence ID" value="GAE67090"/>
        <property type="gene ID" value="JCM18909_126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8775" checksum="6B6C95C8654372CF" modified="2014-03-19" version="1">MQMTVHKRNGIEEPFSRDKVIRGVRNACKGRPVTDADLALLGQRVEDGLRAEGSRRYPARKSGWRSWGHCVSLIPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDV8</accession>
    <name>W4TDV8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integral membrane alanine and valine and leucine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67145">
        <property type="protein sequence ID" value="GAE67145"/>
        <property type="gene ID" value="JCM18909_185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8874" checksum="75BA427B53A8A8CB" modified="2014-03-19" version="1">MVEVFIPEYVVGHWWEHLLHNQTALVARARLHFMPGVLISSVPYQLRSSAILEKRWKRNDPRSWRDPGATITPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE14</accession>
    <name>W4TE14_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67200">
        <property type="protein sequence ID" value="GAE67200"/>
        <property type="gene ID" value="JCM18909_243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="286" mass="30339" checksum="C633209B23B3372B" modified="2014-03-19" version="1">MQTSQPRKVAVVHNSVKTQNNPHWHDLIEKKCREYCGVTPVFFPTTADDHGQGLACKAVDEGAELVLALGGDGTVRQVSAGLANTGVSMGILGMGTGNLLARNLELPHTDLAASLDAALTRPVRAIDLGYVRFDESEEICFTVIIGMGMDAQTMAGTRDRLKDKVGWLAYVASGTLTLVQPGFQARASVDGRRPVITRARTVLVCNCSVLPGGVVLVPDGRIDDGALDVLTLSPHALSDGSPASTTLSPDIGTAIASCATRRRERPSLCPVPARSWRKLMETPSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE23</accession>
    <name>W4TE23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67210">
        <property type="protein sequence ID" value="GAE67210"/>
        <property type="gene ID" value="JCM18909_254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28831" checksum="3771FD0B6656EA37" modified="2014-03-19" version="1">MPMSSRGDEVEFHTVRLVIAQCQVDYTGRLIAHLPWAKRLIVVKSDNSVSVHADDRAYKPLNWMSSPCTLTIRPCLPDEPAATAAVDVEEVWEVDAPTGDHLQILLGSKVLDVTEELGIDPGLQKDGVEAHLQELLAENPHTFGDGWSLVRREYMTPIGPVDLLCRDADGVYVAVEVKRRGEMDGVEQLTRYLELLNRDHLLGDRVRGVFAAQKNQAAGAYPSRRSRDRVRHYRLRRSAWHGPPGGPSLLTCTRLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE43</accession>
    <name>W4TE43_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">JCM18909_81</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67046">
        <property type="protein sequence ID" value="GAE67046"/>
        <property type="gene ID" value="JCM18909_81"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="14"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="158"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="310" mass="34165" checksum="A365E58EBA67A812" modified="2014-03-19" version="1">MLKSSTPTTPDVTFLSVEDMSSDDVMRIIERGRQFKAGDAPRVEPGHVAINMFFENSTRTMTSFQMAEHRLGMKILDFDPGHSSVTKGESLYDSVRTVDAIGAEVAVIRHSTNHYYDYLLSTGMLGLSVVNGGDGSGQHPSQCMLDLMTIAEEFGRVDGLTVAISGDIVHSRVARSDAQILTRLGANVVFTGPREWMDHDVTRLGTMATLDEVIADVDVAMMLRVQHERFDAGPDFSATDYLHTFGLTDERAERMKPHAIIMHPAPVNRGCEISGHLVEAPSSRIFEQMGNGVMVRMAILEQVLHGRETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE72</accession>
    <name>W4TE72_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diaminopimelate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67081">
        <property type="protein sequence ID" value="GAE67081"/>
        <property type="gene ID" value="JCM18909_116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="193" mass="20638" checksum="E4BA4CEF6620A186" modified="2014-03-19" version="1">MRVFARYLVQTGRMTTTEADVATRAGVRHVRLHDGGDVSVTMGTVRVESGKVTIEHQDMWWPACKVDVGNPHAVVVTDHTTVCGINLNDSPTWRPRSAFPDGVNVEFVEQIDQHTVAMRVHERGSGETMSCGTGTVAVAATMATRTGHRGPWTVQVPGGRVVVTLSPSDDGYRAILTGPAVILAAGKVDLPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEB3</accession>
    <name>W4TEB3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67126">
        <property type="protein sequence ID" value="GAE67126"/>
        <property type="gene ID" value="JCM18909_166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="5">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21472" checksum="5ABF844667CE5C5F" modified="2014-03-19" version="1">MRLPLVDGHGNFGSLDAGPAAMRYTECRMAPPALTMIDGLDEDTVDFEPNYDGKETEPTVLPAALPNLLVNGASGIAVGMATNIPPHNLVEVVAALRHMLDHPDADLDEIMRFVPGPDLPTGGRIIGLDGIADAYRTGRGSFKIRATARIEKVSPRRRGIVVTELPYMVGPERIIDQIKTLVQSKKRSPVLPTSRTSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEJ7</accession>
    <name>W4TEJ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67390">
        <property type="protein sequence ID" value="GAE67390"/>
        <property type="gene ID" value="JCM18909_447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10600" checksum="E24BDF2CED893A5E" modified="2014-03-19" version="1">MVIGWTITGIGMICLAMVYQKLAIRRPDLDNGIYAYAKAGFGDFIGFNSAWGYWLSASLATSGIWCCFSRPLASLFLLSRVVTPCGRCLRRQFCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TES4</accession>
    <name>W4TES4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67296">
        <property type="protein sequence ID" value="GAE67296"/>
        <property type="gene ID" value="JCM18909_342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="184" mass="19328" checksum="9CC8DE08C4CE740E" modified="2014-03-19" version="1">MNEMTRARMIAILRLSLLVIAMGIVLGGLAAPLWHSMVTLPTYTVGSDGAATTTEKGLTQVFSTDATYCLIGLVVGLIIGCLSWVLMQRRGAWGVLAAGISACLSALACWWVGVLIGPDSFAERIASAKSGEVIPIDFALHTWVAVLVWLLAAMVPMLIASLLVARRGASRTGRAKTSTGASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TET9</accession>
    <name>W4TET9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secF</name>
        <name evidence="11" type="ORF">JCM18909_358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67311">
        <property type="protein sequence ID" value="GAE67311"/>
        <property type="gene ID" value="JCM18909_358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="391" mass="42570" checksum="7651645CB64FEE08" modified="2014-03-19" version="1">MTDDMNAQTSSVATTRPSDGATSKKRKHNFTHALYTGEISYGFIQRRKVWYTITAAVIIISFIGLLVRGLNLGIEFKGGVQFRAPAHVATSTIDDVRKSVLSSGAPDMDATEVVSLGSDAVQVQTRALNNDETTKVQEAIAKATGTKTSSVTYSKVGSQWGEQITGKAIKALVVFLVLVMLQIWAYFRHWKMSIAALVALLHDLIVTIGIYALVGFTVSPSTVIGVLTILGYSLYDTVVVFDKVRENVQDIDKRDYTFAEGTNRAVNQVLVRSINTTIVGVLPVAALLFAGAFVLGSGPLEDLGLALFVGMIVGAYSSIFIATPVFTQLREHEPAMKEHTARVLRRRERAAQKAPRVTAETVAAEGPRDVTTITGSDRHQPRRSTRAERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEW6</accession>
    <name>W4TEW6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2Fe-2S ferredoxin CbiW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67500">
        <property type="protein sequence ID" value="GAE67500"/>
        <property type="gene ID" value="JCM18909_563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24311" checksum="8BE5759C9424F3B1" modified="2014-03-19" version="1">MVLLEARLHLERTADMTTRIAVSLRWDDAIDLDRAMTQQVAADCIAHLQGPGPTLIDVLDSIDDTRIELVGWSSEDGPVPLSWLRRVAGQWVRDHADGPNVVVHAGAVRPGQTISNEWRAVTGSEAPLRSPAWQEFPPFRHHLLACRGPRCNAAGAADLHARLKDKLAHALDTEILVTVTGCMFPCNHAPLIVVWPDGRCIQLTANNLDRIVEDLIGPSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF52</accession>
    <name>W4TF52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroorotate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_88</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67053">
        <property type="protein sequence ID" value="GAE67053"/>
        <property type="gene ID" value="JCM18909_88"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="7">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17152" checksum="82A7695171BBA194" modified="2014-03-19" version="1">MRINLARRTPVIANATGGLSGPAVLPIAVRMIDAVTRVVDIPVIGMGGVMTSADALELMMAGASAVGVGTANFTDPLACPKIINGLEPLMDDLALPALRTFGLRLGSLVDPTTTQGVHMDITRPIIALDLPAPRQLLTSSVDSTGRPFSSKSAWSCFMQRGLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF74</accession>
    <name>W4TF74_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67620">
        <property type="protein sequence ID" value="GAE67620"/>
        <property type="gene ID" value="JCM18909_693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="297" mass="30755" checksum="3ECA751DD84BB209" modified="2014-03-19" version="1">MDKQTSPQEAIPELAVAVPQDAAALARALDLEAQTVSTWLTQGLGIVARVGSQIVGLAHLVDDGGHADVTDLALTTPDDADVVAALIGGAEQIATELESRVLVVSGLKASPGPAYHYNSGWVRVLPTRVVVPTAEAMHAFGAALAAQLRAGDIVLASGDFGAGKTTLAQGIGRGLGVDGPVISPTFVLARRHAGSGGRPGLVHVDAYRLGSAAELIDLDLDETMDQAVTLIEWGAGIAEDLGGSHLDVDIRRSGDPADETRVVYLEGFGPRWQDVDLSLLSELPLDTISPDQTGDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFE3</accession>
    <name>W4TFE3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67153">
        <property type="protein sequence ID" value="GAE67153"/>
        <property type="gene ID" value="JCM18909_194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041605">
        <property type="entry name" value="Exo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18305">
        <property type="entry name" value="DNA_pol_A_exoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_A_exoN" evidence="2">
        <location>
            <begin position="218"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="307" mass="34854" checksum="17474C425A5419C7" modified="2014-03-19" version="1">MDGLRPDDLFDTELAGRLLNLPRVSLGPMVEHYCGVTLLKEHSASDWSRRPLPRDWQVYAALDVELLNDLREKILSDLHEAGKEEWARQEFAHLVEVAADLPSEEPGIDPKRWRKISHIGDIRSRAGLQLAHDLWLARENLAHDLDIMPGRLLRDEALVAAARHCDRTGNVDVETVLAIRGFHRGRAKKYRQTWAEAINHARSVSPAKYPLLREPSSGIPHPRSWERHHPEEAARWAAVRPAVNDVAADHAVPPENLCTPTWLRHFAWQPPEDCSVEGVDVFLEGLGTRPWQREILARPLSEVMATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFK1</accession>
    <name>W4TFK1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glyoxalase/bleomycin resistance protein/dioxygenase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67750">
        <property type="protein sequence ID" value="GAE67750"/>
        <property type="gene ID" value="JCM18909_831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5619" checksum="D491E58DCB451B39" modified="2014-03-19" version="1">MVPRSSAAVDDAYREGVAKGVHVIEEPHDDVFGRTFVIANPDGNLIRVSPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFQ1</accession>
    <name>W4TFQ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67263">
        <property type="protein sequence ID" value="GAE67263"/>
        <property type="gene ID" value="JCM18909_309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_syn_central" evidence="2">
        <location>
            <begin position="6"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20021" checksum="C16341968DD4F20A" modified="2014-03-19" version="1">MVRGLFAVEEGGEGLRRRIEEIRAEVSEAIAEGTTIIVLSDRHATRELAPIPSLLLTSAIHHHLVREKTRTRAGLVVEAGDVREVHHVALLMGYGASAVNPYLLFESAEDMARREVWVSTDPETAIHNVYKALGKGVLKTMSKMGVSTISSYTGARSSRLPGYRRNSLMSTSPERRVASRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFQ2</accession>
    <name>W4TFQ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67357">
        <property type="protein sequence ID" value="GAE67357"/>
        <property type="gene ID" value="JCM18909_407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10619" checksum="A10D34155C67E8F6" modified="2014-03-19" version="1">MSEDLFGNVTSAQSDATSGGSLDTPNPDAPLAVRLRPRTIDEIVGQQHLLTPGSPLRRLAEGTGAMSVFLWGLPGLVRRRLPRSSPTPRTDVSWRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX6</accession>
    <name>W4TFX6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67875">
        <property type="protein sequence ID" value="GAE67875"/>
        <property type="gene ID" value="JCM18909_967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="12745" checksum="24E2C67EDEDC2BD9" modified="2014-03-19" version="1">MASAIIANAGLTAIIAWSTPVLMFLYPLAITAIILGLLDPWLGASRLPHRIMTGCVALAALPDLVRALPIQGSGTRAITHVADMVLPWASDGLGWGLPAVIGLAAGWGASLILGRPRRWGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG26</accession>
    <name>W4TG26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67741">
        <property type="protein sequence ID" value="GAE67741"/>
        <property type="gene ID" value="JCM18909_822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9196" checksum="6955856E1A151B95" modified="2014-03-19" version="1">MAAPVTYPNGDQCQFLDHDFLCRWVSGEPVVGDDESSHTGFFSIDQLPPMAPRHCRCIETALNPADTVIMSSDMVSPDIQEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG30</accession>
    <name>W4TG30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67477">
        <property type="protein sequence ID" value="GAE67477"/>
        <property type="gene ID" value="JCM18909_539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="23401" checksum="5C0E739BF1FF4ADE" modified="2014-03-19" version="1">MSPAQPRHQVPDARSWEYADGFVAPSPALQEAREAARADQWEVLGNGTTALLTFLARAMQARSVVTIGTDAGVSGLALLEGMTDHGVLTSIDPDAERQAAARKVLSLARIRSNQVRLITGTPLDVLPKLRDGAYDIVLINGDRLEYVEYVSQALRLLRPGGVVVVNDALANNHIADPDNEDDDTLIIRETLDSVLETEEFTPVLLPVGEGLLLATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG59</accession>
    <name>W4TG59_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67930">
        <property type="protein sequence ID" value="GAE67930"/>
        <property type="gene ID" value="JCM18909_1031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000667">
        <property type="entry name" value="Peptidase_S13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30023">
        <property type="entry name" value="PTHR30023"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02113">
        <property type="entry name" value="Peptidase_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00922">
        <property type="entry name" value="DADACBPTASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="481" mass="49909" checksum="7C54B2BC840EE343" modified="2014-03-19" version="1">MPGWVPVTVGIAVVVIVVVAVIVSSLRSGSPARWTGGGILPHRHENTAQAVQPGRGVVAAVAPTTPSAKPVAATIANRVKSAGAAPGVLGADIMDAATGETLYQSGQNSLLTPASNLKVLTAIALLDCTDAGHRYTTKVVANGSALTLVGGGDPYLRSKSSAQHPEYPSMEDLAKRTAAALKKAGTTKVTVSFDDTLFTGPDWNGAWPVDNYSDEVTPITSLWVDEGMINNSPWNRSKTPAVLATNAFIGSLRSAGITVNGSVSRHKADRSAKEIAAVQSLPVEDLVTRTLEESDNSAAEVLSRQMALASGKPGSFAGGTQALEEHLKNIGAWQDGAVIQDGSGLSQGNRITALMLSRAWRKVLTTLKLQPVANAVPVGRVSGTFINDFPIRARQPDAVSFTPRRAVCKESSRCRGGCVTLTGEFWWLPSSSIRLTAVPGRGLTSSTATWPGAAAPADGTTGIRASGPGSRPGRRADGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG79</accession>
    <name>W4TG79_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67537">
        <property type="protein sequence ID" value="GAE67537"/>
        <property type="gene ID" value="JCM18909_603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="170"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="492" mass="52185" checksum="D37D99B91CA0A687" modified="2014-03-19" version="1">MSAVLDELAGGDKATRAALRVFADLNQSWPYRTPDTHAPALTAAVDAFWAARDKGSVDSSLKDRLAVIVRLPEALAGMRQQGFFQDTRPWINAASQWARACQHFVTMLDAIDAGDGAKATNEYLAAQKQVELAKRPTVDDQGSDGVLHKAVIVPSVGDGVFDAFAKKASAQFAAFIGARPASAKAYSGTASSSMGQWEANSPSRMVDGNLSTLYWTNVSPEKGSYIQVDLGSVKPIGQVAVHQADDDTATGDMFYHAALEYSVDRSTWTAAGNFDSAPLIKHTFEKPVQARYVRVRATDANPGAQWVKIREFEVTPPAGVYSTNVKAAEGSSVALAFDGDVSTAFRAATPAKAGDFVSFVLAKGVTPRQAIVVGTARGEIQVRSGQTWTTIGTISDDAPFHAFAVPAGTSVEEVRLMLAAGSPAPVIRGMTVVDRELKPTPTPTPTSTAAPTSGSSTGDDHGRPGYPTPTSTPSHGHARRCRVRESDGFRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE5</accession>
    <name>W4TGE5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67483">
        <property type="protein sequence ID" value="GAE67483"/>
        <property type="gene ID" value="JCM18909_545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="117"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="380" mass="40034" checksum="1105AE3B5950E968" modified="2014-03-19" version="1">MVKAIADALSHVNDPEIKSPITDLNMVDEITVDEQGRAFVRILLTVAGCPLKTELREQAIEAVRSVDGVTSVSVELGTMTDEQRDALKVQLRGDVPERVIPFAQPGNTTKVIAVSSGKGGVGKSSVTVNLALALAQLGREVGLLDADIYGHSVPDMLGLGDAHPTPLNDMLLPVPGLGIKSISIGMMKPNKSDVIAWRGPILDRALTQLLADVHWGDLDYLLIDLPPGTGDIAMSLGQKLPNAEVLVVTTPQQAASEVAERAGTMAGIMQQRVMGVVENMSWLEVTAPKSHETFRVDLFGTGGGQKAADALSERLGTTIPLLGQIPLDVELRSGGDDGDPIVIAHPDSPAAEAITELAKTIDARPRGLVGINLGVQPVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI3</accession>
    <name>W4TGI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RDD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67523">
        <property type="protein sequence ID" value="GAE67523"/>
        <property type="gene ID" value="JCM18909_588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016795">
        <property type="entry name" value="UCP021697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021697">
        <property type="entry name" value="UCP021697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="22"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="14590" checksum="58DFE6D8637D5AE0" modified="2014-03-19" version="1">MSGTEAAPGVSIGLPAEGRGSLASWGKRIGALIIDWGASMVLASAICGPAVIRGGGWPMWMPMAVFFVESVLFTAMIGGSFGQIVARVAVVRLDDLGPVGWWRAVARTAMKCLVIPAVVIGAERRGLDDLVLGTVVVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL5</accession>
    <name>W4TGL5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_754</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67677">
        <property type="protein sequence ID" value="GAE67677"/>
        <property type="gene ID" value="JCM18909_754"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="266"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE67677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="331" mass="35240" checksum="06C986EEBCE8D708" modified="2014-03-19" version="1">MDQRWDDVMALALDMAAKSPCPDPNPRVGCVIVAEDRVIGQGWHRGVGTPHAEVEALRQAGDGARGATAVVTLEPCHHTGRTGPCSHALVDAGIARVVIAQSDPNPVASGGEQWLRTHGVEVVTGVLSEEATALNADWTFSQIHRRPRVCWKYAASLDGRSAAPDGTSQWITGEQARRQVQLGRARCGAIIVGTGTALADNPRLTVRLPGVTHQPLRVVVGMREPPAGCHVRDDSASTLHIPSHDPAEVLDLLWCRGVHRVWLEDGPQLAGAFLAANLVDEVIAHMAPTVLGGGRAAVVDPTVATLSQAHHFVIDDVTQLGPDIQIHAHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGQ9</accession>
    <name>W4TGQ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67339">
        <property type="protein sequence ID" value="GAE67339"/>
        <property type="gene ID" value="JCM18909_386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="22143" checksum="CD123ACB4689D898" modified="2014-03-19" version="1">MFTTVTEAEWATRADPSTLPSGATLERMASVDKAFTKKLAKAITARWGIKNFVNILDGLELETQQLITDNIAAYGEQVRLDHFPNDVERLLVEIIHEKAGTDNGRAKALAKIAIQVARVRYEKLLLARSRGCAKCSRPLGISFHGQQTNSYVIVFLDSDEANTLPMTLLPCVSRAVRNTSSATRRKMLQNCANPTWHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT5</accession>
    <name>W4TGT5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="6" type="ORF">JCM18909_711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TGT5"/>
    <dbReference type="EnsemblBacteria" id="GAE67638">
        <property type="protein sequence ID" value="GAE67638"/>
        <property type="gene ID" value="JCM18909_711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10628" checksum="B28092F4FEAF4E95" modified="2014-03-19" version="1">MATTIKPLEDRVLVQPLEAEQTTASGLVIPDTAKEKPQEGKVISAGPGRVDDKGTRVPMDVKEGDVVIFSKYGGTEVKYDGQEYLLLNARDILAVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW2</accession>
    <name>W4TGW2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68205">
        <property type="protein sequence ID" value="GAE68205"/>
        <property type="gene ID" value="JCM18909_1327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7971" checksum="86BC61AA7FEA4047" modified="2014-03-19" version="1">MLGVHGQATTDRAGDEADRLIARYGSRWRSGRTRYRSVEQAAAVEAAARSTYDWGRYYRGADDADADRSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX2</accession>
    <name>W4TGX2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67782">
        <property type="protein sequence ID" value="GAE67782"/>
        <property type="gene ID" value="JCM18909_865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6985" checksum="DFCAF23B04D0B7FB" modified="2014-03-19" version="1">MSIVSLNGVSYGYPSFDPDSSPFSDGPAPEREFVEQLRDITMTIQPGTLTLLVGASGSGKSPYCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH08</accession>
    <name>W4TH08_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">JCM18909_1379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68255">
        <property type="protein sequence ID" value="GAE68255"/>
        <property type="gene ID" value="JCM18909_1379"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27329" checksum="19D279A43050760C" modified="2014-03-19" version="1">MLTTRATLDKHHADVASMFDGVAKRYDLMNQIMTLGAIDTWRDLVVAAVEPEHGQTILDLAAGTGTSSATFAARGAQVYPTDISTGMLAVGKQRQPHLHFVAGDATCLPYADNSFDAVTISYGLRNVEDPHQALREMLRVTKPGGRVVICEFSYPTWAPFRHVYTKYLLGAIPAMARLASSNRQAYDYLAESILTWPDQPHLADMMAETGWQAVAWRNICGGVVALHRGWKGMPAPVPATTVTATPGKEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH24</accession>
    <name>W4TH24_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68081">
        <property type="protein sequence ID" value="GAE68081"/>
        <property type="gene ID" value="JCM18909_1193"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="552" mass="59517" checksum="09307579401D1672" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH57</accession>
    <name>W4TH57_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="6" type="ORF">JCM18909_520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67459">
        <property type="protein sequence ID" value="GAE67459"/>
        <property type="gene ID" value="JCM18909_520"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="231"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="291" mass="30761" checksum="EEFE4467877CB343" modified="2014-03-19" version="1">MLDTWYPEPQLGCPDDSSAPADLHRVTEAGRDAIRNVHTEVVHTVIDLDAAPVDVPDAYLRLHLLSSRLATPRTINLDGIFGVLPNNAWTTIGPIRMADLEKARMEARIAHAPFTVLLIDKFPRMVDFVVPTGVRIGDADRVRLGAHLAEGTTVMHEGFVNFNAGTLGHSMVEGRISQGVIVGDGTDIGGGASIMGTLSGGGKEQVTIGRGCLLGAEAGIGISLGDNCVVEAGFYVTAGTKVTLPNGKVVKASELSGASDILYIRDSTTGIVKARGRGNHKIELNSDLHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH59</accession>
    <name>W4TH59_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68121">
        <property type="protein sequence ID" value="GAE68121"/>
        <property type="gene ID" value="JCM18909_1238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="205" mass="22361" checksum="3A199148C4AF52EE" modified="2014-03-19" version="1">MKIGVNYTPSQGWFHSWLDLDLDATRRDFEGIAQLGLDHVRLFPLWPLLQPNRGLVRPRALDDVVSVVRAAGEFDLEVTVDALNGHLSSYDFLPSWVVTWHASNLFTNPLVKTGQTDLISQLATRLREEPNVTGMTVGNEFPQYAALAPGIIIRRAASAPSMRPRCGWKRCSGPCGTSGRTDGSGSGSTTTSGLSTTIRSPRVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH60</accession>
    <name>W4TH60_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate dehydrogenase E1 component alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67768">
        <property type="protein sequence ID" value="GAE67768"/>
        <property type="gene ID" value="JCM18909_851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="3">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="173" mass="19172" checksum="72FF74DCB5032470" modified="2014-03-19" version="1">MVFVCVNNQWAISEPTTVQSPTSLFRRATGFGIPAVQVDGNDVIAMMAVLRSALEYARSGKGPVFVEAWTYRMGAHTTTDDPTRYRTAEEESTWGKTDPIVRLRTYLQNRGIINQAWLDGLAESEDAFGAEVRAAVHENATPVMADLMEDVYAEPTPDVLADVEEIASWEEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD1</accession>
    <name>W4THD1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sialic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67559">
        <property type="protein sequence ID" value="GAE67559"/>
        <property type="gene ID" value="JCM18909_626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="92"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="307" mass="34322" checksum="A6844D86D817CD54" modified="2014-03-19" version="1">MYVTASQTAHRLTRDRGMIGYHRHRSFSVSDREHRLANISATTYLQNVGRLTYFLDQRRLGLMASSDDIITIKEMGDKRPWWQYLDATKWKLFIAALIGVTLDGYDFVLITLALPEIKAAFGLTLVQSAALVSAASITRWLGGLILGGVGDRFGRKPAMIIATVLFAIGSLLMGFSPNFMFLFVMRMVVGFAMAGEYGSSATYVIESWHPRIRGKASSFLLSGYAIGAILAVQVDKYLVPWVDSWHAGWGWRALFITGIVPIAVALYMRRRLPEASDWETAKSREREKNRPNHVTLSRCCSAEGACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD3</accession>
    <name>W4THD3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric-oxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68201">
        <property type="protein sequence ID" value="GAE68201"/>
        <property type="gene ID" value="JCM18909_1323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14063" checksum="0A8029533CDE2DDB" modified="2014-03-19" version="1">MLTYVLLGAVAFVVFGSLISEALSVYGVSWAKGPVFGQQWEYIDLSKMFQLLLTLGMFLWVFIIWRAMHTRMRAESFGNMPWVFFLLGPIDPDVLRRGSPRRDAHAALGSRVLAFLGGPSLGRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG5</accession>
    <name>W4THG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67599">
        <property type="protein sequence ID" value="GAE67599"/>
        <property type="gene ID" value="JCM18909_672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11328" checksum="C10AD4FF29AD02F7" modified="2014-03-19" version="1">MLIPGTSEDAFITWSYYGPRLKAAGFCAYTFNYNPETHPLVEAAETSGNIYSTAAFMAHFVDRVLKTTGARRSTSSAIHRAAAPCHARTSNITEAPRRSIISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ1</accession>
    <name>W4THJ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67634">
        <property type="protein sequence ID" value="GAE67634"/>
        <property type="gene ID" value="JCM18909_707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="10753" checksum="A7C057A79A72BB83" modified="2014-03-19" version="1">MLTIRCPATYFLALLLAPLVLLSGCGKFNAGFVIKDEDHIDVTVAFGVLKSSVGRDGSGQSEGLAKRLRGCSELTPPNASLAGKAKVKPFDDGTYVAARSLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ2</accession>
    <name>W4THQ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68321">
        <property type="protein sequence ID" value="GAE68321"/>
        <property type="gene ID" value="JCM18909_1450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6577" checksum="694EE9A7DF7860BB" modified="2014-03-19" version="1">MLFEVLVEVSFLTGDRLDLDDLVNPLILGDLGDDAVGLLTVPSPVDVNAIRSQVFFSASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ3</accession>
    <name>W4THQ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exodeoxyribonuclease V alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68465">
        <property type="protein sequence ID" value="GAE68465"/>
        <property type="gene ID" value="JCM18909_1604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041851">
        <property type="entry name" value="RecD_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="318" mass="33421" checksum="A73A79A263648BD6" modified="2014-03-19" version="1">MTDLVPVAAGLRLEPFARAGVLEASDIHLANLVCRIGGETNCDVSLAIALSCRELRRGSVFWDPHEIANVVRQQILDPAIPDIETSDQAALFAELEWPHPGEWLSTLEASPVIAGRDDPINRLPARLDDGLVYLEKYWQAEHDVARDLATLAADPPSQGPVLADDVVSSVSNALAASGIMLDPAQADAAIAAIMHRVSVLAGGPGTGKTTTVCALLAALQQADPHLGAVALAAPSGKAAARLRDSVSHVSERMPDDLKPIVADATTVHSLLKWQGPGTSFGYDEQHKLPFGVVVVDEASMLSLPLAASSSLQSGLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS5</accession>
    <name>W4THS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68490">
        <property type="protein sequence ID" value="GAE68490"/>
        <property type="gene ID" value="JCM18909_1632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6301" checksum="0B1F299DF7576098" modified="2014-03-19" version="1">MVDLGPDSNVTVGDEVVLIGTQGDETLTADDMAELLGTISYEITCAISKRVDRCWVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT2</accession>
    <name>W4THT2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67734">
        <property type="protein sequence ID" value="GAE67734"/>
        <property type="gene ID" value="JCM18909_814"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="8">
        <location>
            <begin position="48"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="28728" checksum="EB5871EBCAA79A50" modified="2014-03-19" version="1">MAEAGTPETAKTSRVNPMTSPEFTDPQAIARNAADAIRSRLSLTSVDMGLVLGSGWSAGVDRLGKSLGRIPLSELPGFFAPVVAGHGGDLVAVALPSGKTAVVLTGRTHFYEGRGVEPVVHGVRTVAALGATTMILTNGCGGLDPSWGPGTIVAIRDHINLTGATPLRGATFIDMSTTWTPRLLEVTERVAPGTPTGVYAQFRGPQYETPAEVRMARTIGATLSECQPPLRPLPPAKPVSTCSGYPWSPTMQPGSLMPRLTTPTLSLLASRPPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV6</accession>
    <name>W4THV6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapB</name>
        <name evidence="12" type="ORF">JCM18909_1216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68102">
        <property type="protein sequence ID" value="GAE68102"/>
        <property type="gene ID" value="JCM18909_1216"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="107"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE68102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="246" mass="25944" checksum="065B380FE50A452E" modified="2014-03-19" version="1">MIKVAVFGAKGRMGTAVCQAVEEAEDTELVAAVDSGGDRSDASGADVIVDFTTPDAVMDNLSWAISHDINTVVGTTGFDDERYQVLRDQLADHPNIGCLVAPNFSIGAVLMMHFAEQAARFYESAEIVELHHPNKVDAPSGTARTTATKIAAARQEAGLGEVPDATKSQLDGARGAVVEGVHVHSVRLRGLVAHQEVLFGAEGETLTIRHDSMDRVSFMSGVLTGVRGVLNRPGLTVGIEGLLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI83</accession>
    <name>W4TI83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67864">
        <property type="protein sequence ID" value="GAE67864"/>
        <property type="gene ID" value="JCM18909_955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7731" checksum="CA46A51BBEE97358" modified="2014-03-19" version="1">MTHPDVIVADEPTGALDSEASDDLLTFLRHCVDDLGQTVVMVTHDHDAAARADDIVTVTDGQVSTARSQEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF8</accession>
    <name>W4TIF8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68322">
        <property type="protein sequence ID" value="GAE68322"/>
        <property type="gene ID" value="JCM18909_1451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10299" checksum="B8BA4CB954208A7D" modified="2014-03-19" version="1">MQLGHDRPSHIVVPAIHRNRAEVREIFLHEMKNYGRPAPEDISENPPELANAARLHLREKFLRAEMAVSGGNFVLADTGSLVIVESEAMAVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ9</accession>
    <name>W4TIJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68258">
        <property type="protein sequence ID" value="GAE68258"/>
        <property type="gene ID" value="JCM18909_1382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046264">
        <property type="entry name" value="DUF6297"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19814">
        <property type="entry name" value="DUF6297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849098" evidence="2">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="14720" checksum="9C0D8D985E58D09C" modified="2014-03-19" version="1">MLVFSLVVVLAMVISLIVQAQGQASGCTSTGCQTARGLLPWAALSGVLAFALAAARVFGPVLASAAEGFWLMDVPIDRAKFLAKRLRAAVLVSVIAGAVLGAGGCPYWGRWEGRRRLDPGECLGAAGVVSFAGAEQGAERTCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK2</accession>
    <name>W4TIK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68795">
        <property type="protein sequence ID" value="GAE68795"/>
        <property type="gene ID" value="JCM18909_1958"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11332" checksum="A7A4D238B206061A" modified="2014-03-19" version="1">MQTLYEHSRRILAVFLIAALLCLAIIGPLPDTQSSATLTCTTTGIAAIFLVVVASHADPHFGLDSLTFIVTFLASAVCRRAATNPVSHSLYLPVIITAVALAAVGGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ4</accession>
    <name>W4TIQ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FCD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68666">
        <property type="protein sequence ID" value="GAE68666"/>
        <property type="gene ID" value="JCM18909_1817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10407" checksum="5A3D88AE3363ABFC" modified="2014-03-19" version="1">MGMVDSSLAITVSNVLGARIVSGAVTPGTVMKLEELDSEFGVSRSVTREAVKLLEALHMVRARRRIGIVVTEESDWDVSSPAVIEWFFCPGLDGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU0</accession>
    <name>W4TIU0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68875">
        <property type="protein sequence ID" value="GAE68875"/>
        <property type="gene ID" value="JCM18909_2045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17476" checksum="10AA2B045E33B672" modified="2014-03-19" version="1">MSYFDDLDVTGVSLGWITLTKAGRDNPDLCFEEWPWQVAQPIGETMARRAQAVTWARLSDEGLLARRWRIAPNVDSETTGRPGATDPEHIVLRQRRGLCRAVEMTTASGGVLGACDGELTLAQITDAVSAILEVDHDALLIEVLPLVRECLRYGILETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU1</accession>
    <name>W4TIU1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sepF</name>
        <name evidence="9" type="ORF">JCM18909_1857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="6">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SepF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68706">
        <property type="protein sequence ID" value="GAE68706"/>
        <property type="gene ID" value="JCM18909_1857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0717">Septation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="313" mass="35068" checksum="E24633E163A478FD" modified="2014-03-19" version="1">MYPIHDVLDVRVSRQTVAISVAGLNGENPVRGQAHEKELQMAGIGRKIASYVGIVDDRRYDEEYLPDEELTTEVYSDDGYEPSSEVTQLHHHDSNEQHARGHKAVQHRRRPELEEPSIADISRILTVHPCNYNEARTIGEQFREGIPVIMNLTEMDDADAKRLVDFAAGLIFGLRGTIERVTSKVFLLCPRNVNVTPEDKARIASGGFFSTSLDGEAMILTGTILTWIIEIYTVLLIVRMVMSWVPLLIRGFVPRGALAVVFEAVYTVTDPPIKFFDRLVPPVRLGNVGFSVGFIIGFVLLAILQRVVIAIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU6</accession>
    <name>W4TIU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68880">
        <property type="protein sequence ID" value="GAE68880"/>
        <property type="gene ID" value="JCM18909_2051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021202">
        <property type="entry name" value="Rv3654c-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03816">
        <property type="entry name" value="tadE_like_DECH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10132" checksum="3DC65F3F927FA93C" modified="2014-03-19" version="1">MDVTVNHGWWSATHRAEETSDMAALAAGGAQAVGEPGCPVAERTVKANGAELVSCVVHNTENGPSVTVEVGVQLHRGWELPGMPTRVVKSSRAGPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV7</accession>
    <name>W4TIV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1874</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68721">
        <property type="protein sequence ID" value="GAE68721"/>
        <property type="gene ID" value="JCM18909_1874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10156" checksum="0466A7697708FA7F" modified="2014-03-19" version="1">MTVENQHSAVEEQRLRRSLSNRHIQLIAIGGAIGTGLFMGSGKSIRTAGPSIVVAYLVIGAMLFFVMRAMGELLLHNLQWKSFQDFAADLLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY3</accession>
    <name>W4TIY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68487">
        <property type="protein sequence ID" value="GAE68487"/>
        <property type="gene ID" value="JCM18909_1629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="51"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="504" mass="55032" checksum="0095E1FDE8CD0C76" modified="2014-03-19" version="1">MTGFNQIPDRERHPHALASNEHHGLTAQEPGSSPSSPHPEAHLHRNLNNRHIQLIAIGGAIGTGLFLGSGKAIRAAGPSIIVSYLIIGTMLYFVVRAMGELLMYNLDYKSFQDFAADLIGPWAGFFLGWTYWLCWIVTGMAELIGITTYWDFWVKDRKAATLLAAATLFLLLCLNLLTVRMFGELEFWFALIKIIAIISLIVLAIVLAVMKFQFPSGSMASVANLWNRGGFMPNGWSGFFAGFQMAAFAFVGIELIGTTAAETRDPEKTLPRAISAVPARILIFYVGALLAIMTVVPWDEVRADSSPFVQVLGLVGFAGAASVMNFVVLTSAASSSNSGIYSISRMLFGLAHKRMAPKVFGRLSKNGVPRWGLVITVLVLSTALLLAASESFVEAFTLVTTISSVLFIFVWSMIVISYMKYRRVAPAAHAASKYPMPGGRGMCWAVLVFFVFVLVLLAQEADTARALALTPIWFVILGVGWFFDRHHATHDDVGTDEAHPKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC3</accession>
    <name>W4TJC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69050">
        <property type="protein sequence ID" value="GAE69050"/>
        <property type="gene ID" value="JCM18909_2232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="136" mass="15118" checksum="558E67AE77B35871" modified="2014-03-19" version="1">MATGPIADTKPGVIDIKWFEQGVPAHPEHRPDIETTLSWLDGHPERLGIIVEQSPNRTQIKRLVDLMNLDPLLAEDLAEGHQRPKLERHARPCSWCCIRRSTSIRSRTSPLLRPKSLSSAIASSSSCSAYPTSCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ7</accession>
    <name>W4TJJ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68324">
        <property type="protein sequence ID" value="GAE68324"/>
        <property type="gene ID" value="JCM18909_1453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019516">
        <property type="term" value="P:lactate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004452">
        <property type="entry name" value="4Fe-4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47153">
        <property type="entry name" value="PTHR47153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20391" checksum="5BFC0C35C2869449" modified="2014-03-19" version="1">MLADTLGREVLRCIRCASCINICPVYERAGGHAYGSVYPGPIGAVLNPQLRGVEHPVDRGLPYACSLCGACNEVCPVKIPFTDILLKLRNKVVESEKADRIPQDYEVAGEMGLMKTASWAFSDHKHFEAIQVGSRGVGRVLRGKKMGPVPVPVAERWLKYRDVDAPPADTFRTWWKKNREVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ6</accession>
    <name>W4TJQ6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68369">
        <property type="protein sequence ID" value="GAE68369"/>
        <property type="gene ID" value="JCM18909_1498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17819" checksum="5F8B9AB658235879" modified="2014-03-19" version="1">MSEFLVTLLRIAYLAILWIFILFVTNVIRTDIYGHRVPRNAGEAAVESGRRNKGRRTRRREPAPMPTGLQVISGSRAGTFVPLANGVTVGRGNDCTLPIDDDYASTHHAEFSPGIDGAWFVEDLASTNGTHVNGERIENPTRLSVGDEVRIGRTTMTVTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS6</accession>
    <name>W4TJS6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68683">
        <property type="protein sequence ID" value="GAE68683"/>
        <property type="gene ID" value="JCM18909_1834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16687" checksum="D08FE0737EB7F990" modified="2014-03-19" version="1">MSAEPAPRPQQARTAAARSTSLRPVLRALPQRVRQQRMGRLGFVILIVVMLAAGLAGLLVLNTTIQAQSMQIAQETRNLNVLQHQQAVLAAEVDHLRGPQNLQEQAKKLGMRPNPYGSYIDLRTGEVIGTQTKVDGKEVPGVIGETAKPEVGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK31</accession>
    <name>W4TK31_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69156">
        <property type="protein sequence ID" value="GAE69156"/>
        <property type="gene ID" value="JCM18909_2345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="10620" checksum="AD633668CE80983E" modified="2014-03-19" version="1">MGLLESIRRGVEFLMNVVVIGALALWSGHTTTVMRGFAIAYTLVLVPLILALLRRVPKNAVAGDAAGKGGISECGGAQGSGSSADKGSGVACGLGWVVRLLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA4</accession>
    <name>W4TKA4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">JCM18909_2425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69231">
        <property type="protein sequence ID" value="GAE69231"/>
        <property type="gene ID" value="JCM18909_2425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21845" checksum="BEF2D950AEB8607C" modified="2014-03-19" version="1">MSSVPVIPQARGLRHTGPVTVAVVSGPTAVGKGTVVGALLRSHPEIVVSRSVTTRPPRPTERDGIDYDFITPEQFDKLVDDEGLLEWATVHNSHRYGTPRGPVERAVADNRTVVLEIDLQGARQVRETYPQATQIFLAPPSWEELVHRLVGRGTETPEQQKQRLETAKVELANADEFDAVVVNDTVDHAVAHLVELLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM9</accession>
    <name>W4TKM9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ORF">JCM18909_2721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69500">
        <property type="protein sequence ID" value="GAE69500"/>
        <property type="gene ID" value="JCM18909_2721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09719">
        <property type="entry name" value="Cas1_I-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033641">
        <property type="entry name" value="Cas1_I-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019851">
        <property type="entry name" value="CRISPR-assoc_Cas1_ECOLI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03638">
        <property type="entry name" value="cas1_ECOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="312" mass="33997" checksum="9747006A8AEB8A1E" modified="2014-03-19" version="1">MAKPVPGARPAEVQELARAQDRLSFIYVEHCIVNRDSNAITASNQRGTVHVPASIIGALLLGPGTNVTHQAMVLLAESGATTLWVGEQGVRYYAHGRPLARTTRLLQLQAEAVTDRTKRLAVARRMYEMRFPDDVATGLTLQELRGHEGTRVRQAYRDAATKFGVNWDKCSYKVKDFTSSDPANQALTAATTCLYGVVHSVIAALGMSAGLGFVHTGHDRSFVYDVADLYKTSLAVPVAFECAATADIDDLAGITRRAMRDAFHESKLLTKCVQDIHILLNAPGDPDEGYGWDIVDLWDDREGVVAGGRSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN8</accession>
    <name>W4TKN8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68978">
        <property type="protein sequence ID" value="GAE68978"/>
        <property type="gene ID" value="JCM18909_2156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16687" checksum="281393FCF66D4250" modified="2014-03-19" version="1">MPAGAFGVGAAVTKPACAELPSNYSPLKVPGTVVKDIDGLEAGTNHGRAADKYVYSASVVNQWLEKPSTQPKNKKIVFVTFDDGPTTKFTGEQLDNLEKAGARATFFMIPRKCVTWARTCSAARSRWAMRWPSTRTPTTTNTCTTAALRTRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS8</accession>
    <name>W4TKS8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdenum ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69028">
        <property type="protein sequence ID" value="GAE69028"/>
        <property type="gene ID" value="JCM18909_2209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="16773" checksum="59B8D56578FF2A21" modified="2014-03-19" version="1">MNKAVEQNLVNAPRQFASNVLTLVTPAHNPARVTGLNSSLRGAKLVICAPEVPCGNATKKLANKLGVTLKPVSEEQKVTDVRGKVESGEADAGIVYRTDALAAGSKVDVIPIGRANEVVNHYPIATAVGATHQGLAKRFVEYVMSADAQKILSDNGFSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV5</accession>
    <name>W4TKV5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69063">
        <property type="protein sequence ID" value="GAE69063"/>
        <property type="gene ID" value="JCM18909_2246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11961" checksum="F0C1F506135C18DC" modified="2014-03-19" version="1">MTPSPSADRAEIDGVAAVIVLAAGGGTRMKSTKSKLLHEVAGRPMLSWAIGAARGLNPEHLVVVVGHRREQVEAHLAEDAPDVTTAVQAEQKRHWSRRRVWSRGIGRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV7</accession>
    <name>W4TKV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosose dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69585">
        <property type="protein sequence ID" value="GAE69585"/>
        <property type="gene ID" value="JCM18909_2819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="2">
        <location>
            <begin position="170"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="291" mass="31525" checksum="7E2E12C2CCC97880" modified="2014-03-19" version="1">MLLDEYGLKMVLHSHGDSHIETPDEIARIFAATDPTYVNLCLDSGHVVYGGGDPVELCHAYPDRINYVHIKAFDADITREAHEKDWPFGEAVTKGASVCPPQGLPEMHSFVDALAELDKPMYAICEQDCYPCNASFPKQNAIAMREYLASCGLGIKWHPTHSVAEITMTVRIGLIGAGGMGRAHAERITTELSGGRIVAVADINLDNAKVVAEPLGAKAYSSGGGELIADPGIDAVLVATFGKVHAPTWSPPFALVSTCCVRSRWPRRPRTVWPFSRLSRKRVENSSPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY2</accession>
    <name>W4TKY2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyribonucleoside regulator DeoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69192">
        <property type="protein sequence ID" value="GAE69192"/>
        <property type="gene ID" value="JCM18909_2384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="53"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="303" mass="33254" checksum="E44A7830FB9CA474" modified="2014-03-19" version="1">MMALDAARLYHLRGLDQAAVAQVLHVSRPQVSKLLATARELGYIRTHVVDPRESDRELVQTVTQRFRIAGLLLVSPSGPTTGELLHALGAGAAHVTSNLVLPGEEDASFWWSQTVQACALEMARAPLRPRALYQCAGTAPGHDIHLSMRTFMERTDVEVHPCPVPLLHPSVTARLTAEESPAARQHESRRASSAVLILGSSRQDMDLICRSDLVTSQEREQIRRNAVGHLCGRFIDADGRVVAPTLGQRTSSPTLAQLRRSRRTVLITHGAHQVEFVRAATLRGYVDHIVTDVSTAELLLKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY9</accession>
    <name>W4TKY9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68829">
        <property type="protein sequence ID" value="GAE68829"/>
        <property type="gene ID" value="JCM18909_1993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="DUF2510" evidence="7">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="6">
        <location>
            <begin position="104"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="283" mass="31063" checksum="0F1306C8947B610B" modified="2014-03-19" version="1">MTASSWENEPMTNATPPPMGWYPDPAGSDQERYWDGERWTRNLRNPPDPQPRPGVGHVPETLAPVSRVPSSPRPNAAVSRRGNADRSQSPAQSRWGSTADGVPLAGWWWRALSTIIDAVLVWIVVGLTMHETVASIVDGYQTFLATSMRAVNAGASPSDVVTMQSLMKAGFVSDLSNLVGAVIISQAIYQFIMLAACAGSVGQLICGLRVVTLNKGKEHRRLVWWRALIRATVWVCVEIGNQAIVLLTPFSYLMPLWQRSRQTIHDAVAGTQVVRPPRQSDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL70</accession>
    <name>W4TL70_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Competence protein ComEA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2969</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69720">
        <property type="protein sequence ID" value="GAE69720"/>
        <property type="gene ID" value="JCM18909_2969"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="3">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="283" mass="29081" checksum="BE919A57777BB04F" modified="2014-03-19" version="1">MNDDYRDRLEDLIARLPARNLGPRRSATPAEEEPAQEETPTPRRTVSRVHASAVGVLLVVVLSVIAVWLMRSKPTEVPAGAVMVSTVPEGTTMPGRETTESEASSESTTPAALPVATTTPAVGAPIQVHVAGRVKHPGVYTVNPNARVADAIEAAGGMTAGAHPGRLNLAAPVCDGCQVWIPVGGDGAVTPPDQSAGGSSGAVGGSGRSSEVAAASGSDKAPVNLNTANQSELETIDGVGPVMAGKIMAWRQEHGQFASVDQLREISGIGAKTFEKIKPHVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK5</accession>
    <name>W4TLK5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cobalt transport protein CbiN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Energy-coupling factor transporter probable substrate-capture protein CbiN</fullName>
            <shortName evidence="11">ECF transporter S component CbiN</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cbiN</name>
        <name evidence="13" type="ORF">JCM18909_2865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CbiN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69626">
        <property type="protein sequence ID" value="GAE69626"/>
        <property type="gene ID" value="JCM18909_2865"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00330">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003705">
        <property type="entry name" value="CbiN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02553">
        <property type="entry name" value="CbiN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 11" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE69626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="425" mass="45269" checksum="C013EDFAD0D7D064" modified="2014-03-19" version="1">MPESTVAKAHQDNSLTSKSKWVTPVIIVLVVGLFVISMVLGAKKTSGGEEGFGGTDDAAAEAAEKAGAKKWIGPIFEPNSSEVESGLFALQAALGAGIVGYALGRMSGRAKGREELSAPPTSTVSTTCRRLLSPLRRTRRLRSHDNYLSRRRRLGFPLAASPGRGKKSRPVDSPAPDRPVHPVNGDLAVGEAGGRLRHLARGAVGWIISVIVVLGPARIAGRVLWQAVVAPLVFLVIGGISVLVSLGSTPVGTVWWHAGAFSIGPVSSAQAMSLIEHGVCGTLTLMVLAVTTPMVDLLTWLRKFHIPDPLLEIASLTYRLIFVLLDTVVTASEAQHARLGDTPAGRFGGFNRRMNNTAALLGSVGIRAWTRANRLNDGLVNRGFEAALATLPIKRTGSVRYKIIVVIVIAVLWVISWTTTGRIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP2</accession>
    <name>W4TLP2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplK</name>
        <name evidence="11" type="ORF">JCM18909_2916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69671">
        <property type="protein sequence ID" value="GAE69671"/>
        <property type="gene ID" value="JCM18909_2916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15075" checksum="08DF324C44F5F551" modified="2014-03-19" version="1">MPAKKKVAAVVKVAPQAGQATPAPPVGMALGPHGVNIMEFCKAYNAQTEGQRGNIVPVEITIYEDRTFSFVLKTPPAAELIKKAAGIKKGTENPATHKVGKISKDQVREIAETKVPDLNANDIEAAMKIVAGTARSMGVEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW8</accession>
    <name>W4TLW8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type multidrug transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69403">
        <property type="protein sequence ID" value="GAE69403"/>
        <property type="gene ID" value="JCM18909_2612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10468" checksum="473C159482CE35D0" modified="2014-03-19" version="1">MMTFGFAALAMAGSLKAEVTLGLANLVYIVGLVAGAVVWPLADYPKAIRPVIAALPTTALGESLRAWGVGQTLWWPLTSLAGWAILLGLLARKVFTWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM41</accession>
    <name>W4TM41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69259">
        <property type="protein sequence ID" value="GAE69259"/>
        <property type="gene ID" value="JCM18909_2455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6914" checksum="26F43B9AC582E622" modified="2014-03-19" version="1">MREALNDLDHDKVVSIPTPLWKFFIAVATHTPRSAMRFLSRTLSSSRDKDDHPRHTPGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM44</accession>
    <name>W4TM44_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70050">
        <property type="protein sequence ID" value="GAE70050"/>
        <property type="gene ID" value="JCM18909_3334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="5">
        <location>
            <begin position="59"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="406" mass="44873" checksum="786BF922F31DB60D" modified="2014-03-19" version="1">MTDGDTPEDLLIDATDHPDGLDSELPPTTVDGSYDAGQITVLEGLEAVRKRPGMYIGSTGERGLHHCVYEIVDNSVDEAMAGYCDTIQVELLDDNWCQVTDNGRGIPVKEHPVEHIPTVTLVLTKLHAGGKFGNGGYKVSGGLHGVGSSVVNALASHFIVEVRRDGYHWRQSFSLGEPDGPLEQLEALGPDDHEGTTVRFQPSDEIFDAIVFDYQTLSNRFREMAFLNKGLRIVLTDRRADHAAEDGNLVHEDFLYKEGLKDYVRFLTGTRDVINPTIISLESHRPEEGMGLEIAMQWNTSYATSVHTFANAINTIEGGAHEEGFRAALTNTVNRWGETWGLIKKREDRVSGDDIREGLTAVVSIKLTEPQFEGQTKTKLGNAEAKSFVQKNPQRETLRLVRGESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM70</accession>
    <name>W4TM70_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-specific component CbiM of cobalt ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69627">
        <property type="protein sequence ID" value="GAE69627"/>
        <property type="gene ID" value="JCM18909_2866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="4711" checksum="00A17D5EEEB28991" modified="2014-03-19" version="1">MTQVPLALIEGLVGILLFRFLAKVAAPQLKQLGVLDDNPEVAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM89</accession>
    <name>W4TM89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69841">
        <property type="protein sequence ID" value="GAE69841"/>
        <property type="gene ID" value="JCM18909_3098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022395">
        <property type="entry name" value="CHP03773_ABC_transptr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03773">
        <property type="entry name" value="anch_rpt_wall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="16947" checksum="EED06CCC8B0C81F7" modified="2014-03-19" version="1">MPWLGVNTMHESIINGTTGPVHMRLDKVSGPGKMAVFMSGTFGGGVGQRVFDNVGGPTGYTVPANTHAHPNWVFTAPGHYTVTVTQSATTKSGKKLSATGTLHFAVGINASPVAASLGKVSASPKADQNADPGYTIVGRTPDASRVISPRPACLVPVKKRRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB1</accession>
    <name>W4TMB1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rplA</name>
        <name evidence="11" type="ORF">JCM18909_2917</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69672">
        <property type="protein sequence ID" value="GAE69672"/>
        <property type="gene ID" value="JCM18909_2917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="232" mass="24738" checksum="5B2B5E6FCCE74023" modified="2014-03-19" version="1">MKRSKAYRAAAEKVNLDQLYSPEEALALVASGASAKFDETVDVAIRLGVDPKKADQMVRGTVNLPHGTGKTARVLVFATGEKAEAAREAGADEVGDDDLIAKVQGGYLDFDSVVATPDMMGKVGRLGRVLGPRGLMPNPKTGTVTMDVAKAVSDIKGGKIEFRTDRYANLHFLIGKVSFGSEKLAENYFAALDEILRLKPNAAKGRYLRKITVSSTMGPGVQIDPVAARDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF9</accession>
    <name>W4TMF9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69374">
        <property type="protein sequence ID" value="GAE69374"/>
        <property type="gene ID" value="JCM18909_2583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="207" mass="22473" checksum="CB2D6AC36D06BBDF" modified="2014-03-19" version="1">MLGPTGCGKTYLVQTMARQLNVPFAMADATALTEAGYVGEDVENILLKLLQAADFDVKRAERGIVYIDEIDKVARKAENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPQQDFIQIDTTNVLFIVGGAFAGLEDIIAKRIGTRPLGFNNDPGASEVIEGPEALSLVRPEDLHQFGLFQSSSDVCQWLRPCTRSTAKPWFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI0</accession>
    <name>W4TMI0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69399">
        <property type="protein sequence ID" value="GAE69399"/>
        <property type="gene ID" value="JCM18909_2608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="14225" checksum="F4D33E97BCAB369E" modified="2014-03-19" version="1">MLASYDLRPGSTADAPNPNSIVQRRSRDNGRTWGPQTVIHAGTPGRRKVGYSDPSYLVDPATGHILNFHVKSYDRGFATSEVGTDPDDRHVLHAEVSTSTDNGHTWTHRDITREITPDPTTRTRFVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK1</accession>
    <name>W4TMK1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69926">
        <property type="protein sequence ID" value="GAE69926"/>
        <property type="gene ID" value="JCM18909_3194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="47"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="24404" checksum="36FD08BA7196CD90" modified="2014-03-19" version="1">MSQERWDKDEYWQVVDRQVKATGQVCDFIDDAVITPTGERINRQYVGHPGAVGIIALDDQDRVAVVRQYRHPVRMVLVEPPAGLLDVEGEDFLAAAQRELAEEAMLSADDWRVLVDIVTTPGGCQESLRIYLARGLHEVPRPEGFLLEGEEVSMKAGWEPLDDLVEAIYAGQCQSPALVTGVMALELARRTDRVNELRPAHAPWPIRERPGGIDGVRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM4</accession>
    <name>W4TMM4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69424">
        <property type="protein sequence ID" value="GAE69424"/>
        <property type="gene ID" value="JCM18909_2635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10085" checksum="289FDFD1C8B332D8" modified="2014-03-19" version="1">MTERVHAHDSRIVLQVGAGFGRVIMPVVLRQGERPAAPSEIPYKWNPHITCREITTDGIHQIVAQFRIAAKVAYEAGFDGIQVHACHEATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN4</accession>
    <name>W4TMN4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA recombination and repair protein RecO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69434">
        <property type="protein sequence ID" value="GAE69434"/>
        <property type="gene ID" value="JCM18909_2648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9577" checksum="E1CF20C24096B9E5" modified="2014-03-19" version="1">MWDTWAASGFFHPVWGGVVCINCQPPGTPHPHEETISYLRALLVGDWTATRDVAWSRVREGSGLVAAFVSWHMDRGLRSMPLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMP2</accession>
    <name>W4TMP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium and cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69444">
        <property type="protein sequence ID" value="GAE69444"/>
        <property type="gene ID" value="JCM18909_2659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CorC_HlyC" evidence="1">
        <location>
            <begin position="36"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13994" checksum="7643AEE46D6F4C70" modified="2014-03-19" version="1">MDEFGGTAGLVTIEDIVEEIVGEIVDEYDAEPTLTEEIEDGVFRISSRLPVDDLGELFDLKVDDDDVETVGGLMAKELSVVPIPGSVIIWEGLEITAEKATGRRHQVDTCLVKRAPEETPDQEYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ1</accession>
    <name>W4TMQ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69454">
        <property type="protein sequence ID" value="GAE69454"/>
        <property type="gene ID" value="JCM18909_2670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="16453" checksum="97F363EA7E4CB924" modified="2014-03-19" version="1">MNNLIKIMSARKEFGDVITFIVHPDFIRDDRFYPVIPKTIQMVINEAATRPEKLLFIDQDTSAPVNNTDSEMLVMEVSVFTVGRNLDNLVVMINLGKYWESGPDDVSRAVIHTLSRPLSAIMFEEIPEPPLEKDEEGYYSFVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY9</accession>
    <name>W4TMY9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-formyltetrahydrofolate cyclo-ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69778">
        <property type="protein sequence ID" value="GAE69778"/>
        <property type="gene ID" value="JCM18909_3030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="21508" checksum="0691A0C2F43AD371" modified="2014-03-19" version="1">MDPRIGKEELRRRCLAHRAALDHRTRMSRDDRRTEHAMSRLLWAHKVALYLSRGDEPDTVDLADTLIMMGKKVLAPVLTDGHGRSLHEPAWAWYDSKNVRTGLWQIPEPIALFSLPRRSTRSRWCCARRSSSIDPDTASGWAVVGTTASSPTGPMTSQCGRLSMTTRSSTRCPTTHGTSPSRRLLPPVDCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN17</accession>
    <name>W4TN17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69907">
        <property type="protein sequence ID" value="GAE69907"/>
        <property type="gene ID" value="JCM18909_3173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSHCT" evidence="1">
        <location>
            <begin position="141"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="312" mass="34445" checksum="52D5346BE4160773" modified="2014-03-19" version="1">MTPDRTVIRLGHQDIDAPVTRVAGVKVPRHFHPENQADRRCLGKAFDRVLEGLGRPVVKPRRAAVDAELSDQITELRSQMKAHPCHSCPDRESHARFAERAMRLRRRSERELTKARAKATSIATQFERIALVLEALGYLDTGGDTVTDAGRMLSGIYSELDLVTVEAIRRGVFDGLDCPQLAAVLSTIVHESRPGDRGHLHRMPDGKSEAAESQLRAVRAEIGLLERDHRIERPRDLDIGFAEASYAWAAGAGLDTVLDDMSAGDFVRRVRQVCDLAGQIAHAGVGENLAHTCRQVVGAMQRGVVTMDREED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB4</accession>
    <name>W4TNB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidine/deoxycytidylate deaminase/NUDIX/methyltransferase domains protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69898">
        <property type="protein sequence ID" value="GAE69898"/>
        <property type="gene ID" value="JCM18909_3164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17414" checksum="4C1EBD72A715BEC4" modified="2014-03-19" version="1">MLPIPEIPEPVTKALHNALEMGYFTTTRNETGRFMATLAAGVHGAIGECETGSGAGAAWLRLGARKRTRVVSYEPDPTVCARAREVLADLDIEVIEGTWDDLLDHGPFGLLSVPIRVARARDVDEILKAVSVGGLVVIDDMPPVMVFLPTTSMAPSIPPGWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI0</accession>
    <name>W4TNI0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Non-specific DNA-binding protein Dps</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70097">
        <property type="protein sequence ID" value="GAE70097"/>
        <property type="gene ID" value="JCM18909_3387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016722">
        <property type="term" value="F:oxidoreductase activity, acting on metal ions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002177">
        <property type="entry name" value="DPS_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023188">
        <property type="entry name" value="DPS_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42932">
        <property type="entry name" value="PTHR42932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00818">
        <property type="entry name" value="DPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8578" checksum="C816DDF893441944" modified="2014-03-19" version="1">MANTVNVPNPAGQTTTKLENAESGFKASETLAANLQKVLVDFIALELVGKHAHWNIVGPNFRDLHLNLDEVVEIARER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP5</accession>
    <name>W4TNP5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70585">
        <property type="protein sequence ID" value="GAE70585"/>
        <property type="gene ID" value="JCM18909_3935"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19398" checksum="D66603D3C7CB78E6" modified="2014-03-19" version="1">MPSYRTTPDGKDYRLVITVTDEVTTCVIERIREGTWVPVQTWNTDVTARTRAPERRLKITESAANHGWQVPADAWGHPPQPNRRQDHPPHRVGLRSADATRRRDEALAQLGTIDLAWRDVLADAAAIGHLPATTIAEAAGVSRVRVYQLREEQRERMNALDAGRSLAKRRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNS4</accession>
    <name>W4TNS4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69859">
        <property type="protein sequence ID" value="GAE69859"/>
        <property type="gene ID" value="JCM18909_3121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003752">
        <property type="entry name" value="DiS_bond_form_DsbB/BdbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023380">
        <property type="entry name" value="DsbB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02600">
        <property type="entry name" value="DsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158442">
        <property type="entry name" value="SSF158442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11265" checksum="49E128C5969E83F9" modified="2014-03-19" version="1">MGFWGANLFVLAYIGVLAGGFIVQFGLHEFPCPLCMLQRYSMMLASLGPLYIIVRTRRGSVTMADFLPGLWRIDPLGGPWRSGIGTSHPVAYSTWGPRIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU6</accession>
    <name>W4TNU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70073">
        <property type="protein sequence ID" value="GAE70073"/>
        <property type="gene ID" value="JCM18909_3358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9786" checksum="6710433C0959FCF2" modified="2014-03-19" version="1">MNYFPVGMLTVIVYMMPMICLACNGNMFRSLIIGAIYMFFVEWGASFFAPEATAMMHATGVHVSGSVTDAFFGYNLPNVIISAIHRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV4</accession>
    <name>W4TNV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70650">
        <property type="protein sequence ID" value="GAE70650"/>
        <property type="gene ID" value="JCM18909_4018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7705" checksum="E48D87724CDD0C5D" modified="2014-03-19" version="1">MLRAIVGRATGATARRKLEKLQLSQAKRVRKDAKQRRKEDAKAAKKKMPSSARRTLRSTASSIPMTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP46</accession>
    <name>W4TP46_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70486">
        <property type="protein sequence ID" value="GAE70486"/>
        <property type="gene ID" value="JCM18909_3813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18308" checksum="4BCD319329F211F0" modified="2014-03-19" version="1">MLDDLSAGRREFVRDRTFYEGDIADQDLLDRVFSENQIDAVVHCAAKIIVPESVDEPLTYYGNNVGKTVALLKGMERNGVHRILFSSSASIYATDEEFKVTEESALDPGSPYATTKFMVEFILRDAAHASDLKALSLRYFNPIGSDPKLRTGQQIEHPTMCSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP63</accession>
    <name>W4TP63_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69984">
        <property type="protein sequence ID" value="GAE69984"/>
        <property type="gene ID" value="JCM18909_3260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016570">
        <property type="entry name" value="UCP010361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010361">
        <property type="entry name" value="UCP010361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="438" mass="48283" checksum="17D8C1B974C2384A" modified="2014-03-19" version="1">MPSRDAKPARQESRAELFSAAGAIVLWTVGRLVMLHVFIQPSSNYITGDLRYYLWWMSSGQPDSSVLPEYPLPVVWFMRTLYWAGGDTYFPMAFSMTMLLLDAILAVAMWHDGHRAGALWWIVLVPFLGPIMWNRFDMVPAVCMGLAALWYRRHPAACGAMIALGAATKLWPALLILPMISRHRAAVRRLIAFAITGFGLALASLLAGGWERLVSPLTWQSGRGLQIESVPATIPMLHYFRNPHGDHTVRMSSYNAYEIFGPSVASWKSVSTGLMVLTVALAIGLAVVSWRRNGLDHRTAVMADLVIIGALIVANKTLSPQYFIWWAAPTAMILDRVSAETKDPGDSDALSWARTWCWIVAVLMAVTTFMTQQVYPLHYQKILGGSSSTGWLLVSRNMLVVMTFAACIATLVTSLRMHVPAQPTATPGGPRHAALAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPB1</accession>
    <name>W4TPB1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Imidazolonepropionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70039">
        <property type="protein sequence ID" value="GAE70039"/>
        <property type="gene ID" value="JCM18909_3320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="16763" checksum="9A9D78A00ED839B2" modified="2014-03-19" version="1">MGLAAVDHCTFLSDEDIDALKTTRTVATLLPAAEFSTKQPYPDARRLFDAGVTVALATDCNPGTAFTSSIPFCLAIAVREMGMTPEQALWSATAGGAAALHRDDVGVVKPGARANLVSLAAPSWLHLMYRPGVPLIDRVCKAGRFLRLDQPRLRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPH2</accession>
    <name>W4TPH2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70313">
        <property type="protein sequence ID" value="GAE70313"/>
        <property type="gene ID" value="JCM18909_3627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18119" checksum="E27BFCE13846C457" modified="2014-03-19" version="1">MTGASGGAYHRRVISHDLHALGFDAPDLDALVNSAAEAGAVGVEDVGGFDLLAAYTDPSGARLAFMKQKSHDEMETMASLVAPTTHPADLVRFSPAVALVDIYSHAGLASMLTGESVLTLPTTNRRHVARFLANVDDPVEVPLCAEPGDDTPRFVEHLRVGAVANQMLRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPH3</accession>
    <name>W4TPH3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70109">
        <property type="protein sequence ID" value="GAE70109"/>
        <property type="gene ID" value="JCM18909_3400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20713" checksum="14640624A5FD07B7" modified="2014-03-19" version="1">MIMKKLLIDYAEVISRPFPDTAMTELAQRAAMSASDFRQRYWEYREPYDCGQSPRDYWQKVLGADYKLGDEELAAFVRIDVDGWLNLDPAAVEWLTKLNESGVRPWLLSNAPHPLAEAIADLPIASLFNGMLFSARLGMAKPSQGCFVAATRAMEARPEDIMFIDDRSVNTDAAAEFGMSTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPI5</accession>
    <name>W4TPI5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome (Plasmid) partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70124">
        <property type="protein sequence ID" value="GAE70124"/>
        <property type="gene ID" value="JCM18909_3420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="207" mass="23086" checksum="55CA3F388560C3B0" modified="2014-03-19" version="1">MDEVSPNARQPRKTFNEEELTELSESIRAVGVLQPVVVTPADNGYELVMGERRWRAARKAGLATVPAIVRTTASEDMLRDALLENLHRVQLNPLEEAAAYEQMLNDFGCTQDELSEKIQRSRSQIANTIRLLKLSAGVQKRLLDGEITAGHARCLLAIDNPEVQVGTANRVVDEGLSVRATEELVRQTLDDTTEVKPHQRKKTRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPN6</accession>
    <name>W4TPN6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70373">
        <property type="protein sequence ID" value="GAE70373"/>
        <property type="gene ID" value="JCM18909_3689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="276" mass="30324" checksum="26BA4B9F61DC151D" modified="2014-03-19" version="1">MSPVLGILNGVQNEMSTAAAGEKDSFAVAATSLAVAEDELARSSTGTESSAEEEWWKAEGMPWNHKPGRSDYWCMGWIGFLGIFSLAMLPLRGWLLGLDPPILMGLTGSRTGAAATGALASVGQVPYWLWWLLLGSIMSIKLDWVYWWAGKLWGRGMIEVWAGRSERAHRRYDQAEKWARKLGWLGVLVAYVPIPLPIMPVVFVLTGASGMKVRWFIALDFVAATIWNLGYLGLGWGVGGPIVDALKYYAKIANWVAIALIIVILAPIFVKKKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPU2</accession>
    <name>W4TPU2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70249">
        <property type="protein sequence ID" value="GAE70249"/>
        <property type="gene ID" value="JCM18909_3552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9792" checksum="F3D47DA4054957B9" modified="2014-03-19" version="1">MTKQEFILTFISVAIFLVLLVPTLIYKIRRERKLPTGEPVPVTQGQRFMALLGDAMWVGLLTLAGWGLFSGATLGYEFNHVDQKISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQM3</accession>
    <name>W4TQM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70529">
        <property type="protein sequence ID" value="GAE70529"/>
        <property type="gene ID" value="JCM18909_3866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6448" checksum="CE269A4FB757D5C7" modified="2014-03-19" version="1">MASTMVRKLVSELVVAADRFCKPILQALFDVVINDGLLAPKGDDPDTAHAYRICASTVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDZ7</accession>
    <name>W4TDZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sbp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67185">
        <property type="protein sequence ID" value="GAE67185"/>
        <property type="gene ID" value="JCM18909_228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009709">
        <property type="entry name" value="DUF1290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06947">
        <property type="entry name" value="DUF1290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018579">
        <property type="entry name" value="Sbp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11562" checksum="5BDBF3A7BDC749A5" modified="2014-03-19" version="1">MIALIGLMVGIIIGIVVNPTLPPGLQPYLPIMIVAALDAIFGAVRAYLAHTFSDRVFVVSFLSNVAIAALIVWVGDQIGVGSQLSTAVVVVLGIRIFTNAAAIRREVLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE57</accession>
    <name>W4TE57_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="7">PRA-CH</shortName>
            <ecNumber evidence="7">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisI</name>
        <name evidence="9" type="ORF">JCM18909_295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PRA-CH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67250">
        <property type="protein sequence ID" value="GAE67250"/>
        <property type="gene ID" value="JCM18909_295"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRA-CH" evidence="8">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13470" checksum="FDF16B4816419040" modified="2014-03-19" version="1">MQTEEPTLAPAIAARLRRNDAGLVPAVVQDAATGDVLMMAWMDDVALARTLATRRATYWSRSRQEYWVKGETSGHTQHVRSVRLDCDGDTLLLRVDQVDGACHTGDHTCFDADVLLAEEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TED2</accession>
    <name>W4TED2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67325">
        <property type="protein sequence ID" value="GAE67325"/>
        <property type="gene ID" value="JCM18909_372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="7321" checksum="6DDF2F5F72D73AC5" modified="2014-03-19" version="1">MVKNSNLARYFETADEKTRNSYLVRNRSPWYKMEYRELAPFLLTYLARQIPRWRLFGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEG5</accession>
    <name>W4TEG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67360">
        <property type="protein sequence ID" value="GAE67360"/>
        <property type="gene ID" value="JCM18909_410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="15978" checksum="3F9D50862D35E2A8" modified="2014-03-19" version="1">MTLGQIAGLIAALAAVVLVALCAVPLLKLGGVLDEVRKAVCDVDESTVPILEELKSTVVITNGEISKLDQVIEDIHTISGHGTIVTGQAAELAQTFTQTVGTPMVKAAAFGEGVRRTIHRPKRRMRQSQVENTVSPTEVSHSAAAAEGGGEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF60</accession>
    <name>W4TF60_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_98</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67063">
        <property type="protein sequence ID" value="GAE67063"/>
        <property type="gene ID" value="JCM18909_98"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="267" mass="28139" checksum="F281F256A75ADA53" modified="2014-03-19" version="1">MPSDAHSTSSRRNDRMVAILAMLRDRDEVPLRDMASALGASAATIRRDVVSLAEQGLLIRSHGTARRAGTGAELPVNLRDGRRRRAKEAIAHAVASELPIGRHAIGLTGGTTTTEIVRALHHRHDLTLITNSVSIALEAASQGQQRVLITGGVLRPSSLELVGSLAESTFKQVNVGTAIVGCDGMSAEGGLTTHDGIEAATNHTMIKRAAHIIAAVDGSKIGRVTLAKLAEAKDVDLLITDDSADPEELARLRALGIAIRIVHAPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF65</accession>
    <name>W4TF65_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67610">
        <property type="protein sequence ID" value="GAE67610"/>
        <property type="gene ID" value="JCM18909_683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="293" mass="32008" checksum="DADD3628B34470AB" modified="2014-03-19" version="1">MRVAIITESFLPQVNGVTNSVLRVLEHLSAHDHDAIVLAPGDAQTPHEYAGFPVIPLASLHWPGYQDVRVSTSPQWTMERYLSEFEPDVVHLAGPFMIGYKGAMAAASLGIPIVAIYQTDIPSYAGRYGLGKLEFYGWYRVRQIHSLAVATYAPSTFSRDQLVSHGVPRVDIWGRGVDKMRFHPSKRSQQLHDEWAPNGEVVIGYMGRLAAEKRVADMTNLADIPNTKLVIVGDGPARAEVEKQLPHAVFTGGLGGEDLPRAVASMDVFCSTGELETFLPGCPGGQGLWPPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFE9</accession>
    <name>W4TFE9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67252">
        <property type="protein sequence ID" value="GAE67252"/>
        <property type="gene ID" value="JCM18909_297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019051">
        <property type="entry name" value="Trp_biosyn_TM_oprn/chp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09534">
        <property type="entry name" value="Trp_oprn_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="229" mass="23818" checksum="7B317F1098AE03D9" modified="2014-03-19" version="1">MTPPIPSGWRVVHGAVPMMTAILISVSSRRIWLERAGIGLTGADVTGGLMTATALMLIVTVALLLVVRTIGRRVTGILQALVGIGIVAIVVTHRTATAHQWAAQGVDAGAPQVHVSAWPWVCLVAGALTILSGIGLAVLADRWPSRSARRTGELTGDPRSVWDALDRGEDPTVGDVVEVPAEKAESTFPPSHNEASRSGSSESTVDKSVHSDSSGSHNGQRTCIDGTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFK3</accession>
    <name>W4TFK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67551">
        <property type="protein sequence ID" value="GAE67551"/>
        <property type="gene ID" value="JCM18909_618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15324" checksum="D48DA694AF8DEE33" modified="2014-03-19" version="1">MLAQAETRRDQTVRDLVVGGQPDHVWAADREARPIVEDMLSDIDLDRAMADLSGGERQRAALVSIMLEDHDLLVLDEPTNHLDVEAVAWLAGICATYRSAAWQCSSSHTTVGFLTRSALTSGRSTTPPSRLTRADTRPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT3</accession>
    <name>W4TFT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67387">
        <property type="protein sequence ID" value="GAE67387"/>
        <property type="gene ID" value="JCM18909_443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13143" checksum="4F1692CA8D1BFF65" modified="2014-03-19" version="1">MSRILMILTSHDQLGDTGRKTGFWLEEFAAPYYVFCDAGHDVTLASPRGGQPPIDPSSSLPQMQTDATRRFDVDEQAKRALTTTTPLSEVDIATFDAVFYGWPRSAVGSGGRSHLAADHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT6</accession>
    <name>W4TFT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YbbM seven transmembrane helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_18</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66989">
        <property type="protein sequence ID" value="GAE66989"/>
        <property type="gene ID" value="JCM18909_18"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849058" evidence="7">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE66989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="7993" checksum="B9DC88D014E560D2" modified="2014-03-19" version="1">MVLLVALAVIASLVGRLGIAKASIIASVRAVVQLGIVSVILVYALAHMWAACLFTVLMFAIAVHTTANRSGVSAAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFU1</accession>
    <name>W4TFU1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sigma-70, region 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_23</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66994">
        <property type="protein sequence ID" value="GAE66994"/>
        <property type="gene ID" value="JCM18909_23"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE66994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="10079" checksum="4FB9775C2B83B9AB" modified="2014-03-19" version="1">MREAAEVARIEEELTARWHSVPSSDAIAAQMGKDVMWVEKRRVECWEVETSFFRAGGCCSEKLRRSRVWAHWPADGSGETHRGAEARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY2</accession>
    <name>W4TFY2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldo_ket_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_79</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67044">
        <property type="protein sequence ID" value="GAE67044"/>
        <property type="gene ID" value="JCM18909_79"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="31"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="336" mass="37169" checksum="52D48501F3256657" modified="2014-03-19" version="1">MAVSTYEAAQDRYDTMEYRRCGTSGLLLPAVSLGLWHNFGDSHPGSTQRAVLRRAFDRGITHFDLANNYGPPYGQAEINFGRIMATDFKPYRDELIISSKAGYDMWPGPYGQGGSRKYLIASCDQSLKRMGLDYVDIFYSHRFDPETPLEETMGALDRIVRSGRALYAGISSYDPTETERAATIARDLGTPLLIHQPRYNMFDRWIEDGLVDTCEQEGMGIICFSPLAQGILTDKYLRGVPAQSRAGMGAVSLRPDQIDDATRAAIAALNEVAKDRDQTLAQMALSWILREPRITSVLVGASSVPQLDSDIDALGATPFTDGERVRIESVLADHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ4</accession>
    <name>W4TFZ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67353">
        <property type="protein sequence ID" value="GAE67353"/>
        <property type="gene ID" value="JCM18909_403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="305" mass="34724" checksum="0417CAAD208CA07F" modified="2014-03-19" version="1">MRWIRGQEADQLEPLETLVINLDVIDSVGVFQTMHREGAEPKILNLQWLPPSHYHHKVNFAAMGLAYALFPTLCSGERTAGEVTELVRRWTISPLAHQARVAWIQPGIRDDLAREHVDPDIPTVLYPAIHLTETKRPKVFLDVMNRVAADMDVRMEARLSQRDLASVMAMKMSSPKWASVGPLFGQREEYWESLARMTAFLATAKNEAYGFEYLEALVAGAIGIFPDTTWARKTVPEDYPYFYRTSDEAVSMLKEVLNDPQTARNAINELAGGSIRDWILEHNQRSGGNEAMRKQIEEWFPEIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG35</accession>
    <name>W4TG35_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67751">
        <property type="protein sequence ID" value="GAE67751"/>
        <property type="gene ID" value="JCM18909_832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8602" checksum="F7B63D156241A866" modified="2014-03-19" version="1">MSAPNLFLTYVSDAKRSTAFYSDLFDIESNFTSPRYVAFEVTPGALFAIWTGRNGDTTRDTPRTSEIAHGPPVVRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG76</accession>
    <name>W4TG76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67413">
        <property type="protein sequence ID" value="GAE67413"/>
        <property type="gene ID" value="JCM18909_472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024067">
        <property type="entry name" value="Me-malonyl-CoA_mutase_sm_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="4">
        <location>
            <begin position="64"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14499" checksum="E53A81C53444B3B7" modified="2014-03-19" version="1">MTDPDNLASKSVEDRMPEELSLAGDFPKVTHEQWEEAVLKVLNRGRPEGKELNIEQGMKRLEPTTVDGIQIEPMYRRQDAPEKLGVPGVPPFTRGTTIREGGMDAWDVRALHEDPDVAFTKKGRHRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG82</accession>
    <name>W4TG82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dipeptide transport ATP-binding protein DppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67801">
        <property type="protein sequence ID" value="GAE67801"/>
        <property type="gene ID" value="JCM18909_886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7808" checksum="7FCF727FA40EE596" modified="2014-03-19" version="1">MLEPHLIVCDEPASALDVSVQAQVLNLMCRLQQEQNLTYIFISHDLSVVRYMSDRIAVMYLGKNRGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG85</accession>
    <name>W4TG85_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67965">
        <property type="protein sequence ID" value="GAE67965"/>
        <property type="gene ID" value="JCM18909_1067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="225" mass="24826" checksum="A029F7B2050CEF8E" modified="2014-03-19" version="1">MMMPVSGEHDLKRVEKDTGERRGVLALLTAATIVAAVCGVIPSIWAVRAGVLVALVGAWVSVFMAWRQVDAIRRMHFDTLKDLRHATSEQEKRHHAESMEMIDTFSRRVGSISKTLADTRAKLDRAESELSTLRGDKAALQYKVTAGNKKVAFLEMRITELETELDALLADGRSGRLTTLRTVTDAGVPTAEEIWEGGNDATIADLSRVAFPRLSEGPRETRRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG91</accession>
    <name>W4TG91_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67169">
        <property type="protein sequence ID" value="GAE67169"/>
        <property type="gene ID" value="JCM18909_211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7444" checksum="A82F8C1F91C81A7B" modified="2014-03-19" version="1">MFRSIWMLSIHAHDFFQQYMPSNRLLAATRTWRGLKWGVPALLVGVPYLANVNVCTILIDRGAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG94</accession>
    <name>W4TG94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67975">
        <property type="protein sequence ID" value="GAE67975"/>
        <property type="gene ID" value="JCM18909_1078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7869" checksum="34BA4511CE0C4737" modified="2014-03-19" version="1">MTLDDDAPIWAKTIIDGLNRPFPWGSAHQPRDQTMSTSLHGASTRPSTVAWTGTRRSTCSGRRSPCSAARIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA3</accession>
    <name>W4TGA3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosine/purine/uracil/thiamine/allantoin permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67438">
        <property type="protein sequence ID" value="GAE67438"/>
        <property type="gene ID" value="JCM18909_499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12306" checksum="E2AB4A16A60BFAE8" modified="2014-03-19" version="1">MAAILSLLAGAINGIYSSGLTLLTLGIRVPRPAASLIDGTILTIGTLYVVFVAPNFISPFQSFLVTLGVPLSGWTGIMMADITLRRRPYDEADLFNGSGSMALGATVVSTPSQSSPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE0</accession>
    <name>W4TGE0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67478">
        <property type="protein sequence ID" value="GAE67478"/>
        <property type="gene ID" value="JCM18909_540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16660" checksum="BBB2E8031ECC2DA8" modified="2014-03-19" version="1">MDLRRTGELAHKLVEEQNNDGIVVNGTTGESPTTTDSEKAEIVKAVVEAVGSDAAVVAGVGTNDTAHTIELAHQAAEAGADGLLVVTPYYSKPSQAGIIEHFTAVADATDLPSCFMTFRDAPVLRLRRRPSSNWPTIHELWPSRTPRGLSLSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI9</accession>
    <name>W4TGI9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="6">4.1.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Fructose-1,6-bisphosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_989</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67896">
        <property type="protein sequence ID" value="GAE67896"/>
        <property type="gene ID" value="JCM18909_989"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="PTHR30559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20415" checksum="922315DA5407E814" modified="2014-03-19" version="1">MPIATPEVYGEMIDRAKEQGFAYPAINVTSSQTLNAALQGFTEAGSDGIVQISTGGAEYASGQTVKDMVTGAVALAEYAHVVAKNYPINVALHTDHCQKEKLDKYVNPLIAISQERVDKGQDPLFNSHMWDGSAIEVEENLQIAEELLSRTAKAKLILEIEVGAVGGEEDGVTGEINEKLYTTVADGMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN9</accession>
    <name>W4TGN9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amino_oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67921">
        <property type="protein sequence ID" value="GAE67921"/>
        <property type="gene ID" value="JCM18909_1020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="449" mass="47734" checksum="826AD9C310795F58" modified="2014-03-19" version="1">MYDSIIIGAGLAGLTAAEELASAGHSVVVLEARARVGGRLENAELSNGQVVELGGQWVGEGHEELRSLLSSQGLELVDSTDGDVVVKARGRVSHVTSLSEPSAHSLSPFELADLGQGLLRFRRLADRVANNKGWAAANVTWLNQSLSQWTVSNVRTEAGRGYITNLFRQAFGVSANDTPLFNGLAKANAGVDLESLVAVNGGLKQQRVKGGVAQVTRNLAEPLGDDLKLSSPVRSVHSDDDGVIVTTTDGTQYQGRSVIVTVPPRLLKDMTFEPALPAERLEMADKVPAGNVIKAYLVYDSPWWRTSGASGQMGADEGAVRVIFDTSDDETGKGILMGFFEGTEASGYGKLSIGLRQRAFEEVVESAFGKAPSSPIEYLDRDWLSEPYTGGCHGAHFAPSLWTTTGPILAEPLGRVLFAGAEYASSFNGYMEGALRAAARAAQEVLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS6</accession>
    <name>W4TGS6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein JCM18909_1289</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68170">
        <property type="protein sequence ID" value="GAE68170"/>
        <property type="gene ID" value="JCM18909_1289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15292" checksum="E64CCB72E1A43046" modified="2014-03-19" version="1">MMTPKPLLAELTTARGAALRGRRGCRPAFGAWGEDLAAQYVESLGWTIIARNWMCDVGEIDLIARDDQTVVFIEVKARSGTGFGDPLESITTAKVRKLHELALAWLVNQDEGVHSVRIDAIGVMVRPGAEPTVTHVRGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT1</accession>
    <name>W4TGT1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67359">
        <property type="protein sequence ID" value="GAE67359"/>
        <property type="gene ID" value="JCM18909_409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_assoc_2" evidence="2">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="MgsA_C" evidence="1">
        <location>
            <begin position="109"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="270" mass="28526" checksum="A2C7FA462F8ABC6E" modified="2014-03-19" version="1">MTLKPLTEADVSSLLDRALNDPRGLRTESDRRYVLKDDARADLLQLTGGDARRALTYLEEAAAGASAAGTDTITSQIVSTAVDRAAVRYDRDGDQHYDVISAFIKSVRGSDVDAALHYLARMIEAGEDPRFIARRLIILASEDIGMAAPSVLQTCVAAAQAVQLIGMPEARLNLAQATIAAATAPKSNAVITAIDGALADVRAGKGGEVPAHLRDAHYSSATIWATASDIVTPTISRMGLPSSSICPTISPRPGITTRPIMAMRLPSHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW0</accession>
    <name>W4TGW0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67663">
        <property type="protein sequence ID" value="GAE67663"/>
        <property type="gene ID" value="JCM18909_738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="327" mass="34759" checksum="035CF782960B3753" modified="2014-03-19" version="1">MNLAIKRGSISAVIGHSGAGKSTLVRLINGLETPTRGRVLVDGTDVSQLSDKAMRPLRADIGMIFQQFNLFGSRTIYDNVAYPLKLAHWKKADEKKRVTELLSFVGLTSKAWDHPDQLSGGQKQRVGIARALATKPSILLADESTSALDPETTADVLSLLKRVNAKLGVTVVVITHEMEVVRSIAQQVSVLAAGHLVESGSARQVFAHPQSETTQRFLATIIGQHPNGEEQARLQSENPHARLVDVSSVASHSFGDALACISHTGASFQIVHGGVIEVHDGSLGNYTVALSGPAQAVEQAAQILDEVSHSAAPTTSATVPTPTEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH85</accession>
    <name>W4TH85_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68325">
        <property type="protein sequence ID" value="GAE68325"/>
        <property type="gene ID" value="JCM18909_1454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="53"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="226" mass="24081" checksum="E990E7D27718AB21" modified="2014-03-19" version="1">MTTISTDPVARTEILARIRRASTGITNPDPITDVPIEWEYGTGIDMDDVVGTFVEKVIDYKATVVRIKGADVPQAVVEGLRSTGAEHSAVVPVGLDKSWVEAIKTAGFDARVDDPQLSKKDLNDTDAVVTGAACGIADTGSIVLTHVEDQGRRAITLVPDRHVCVVKASQVVSDVPEAVQIVKPAVHEGHPLTFISGGSATSDIELSRVDGVHGPRRLYVIVVDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH87</accession>
    <name>W4TH87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67499">
        <property type="protein sequence ID" value="GAE67499"/>
        <property type="gene ID" value="JCM18909_562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6068" checksum="DA4A06F64BD3E120" modified="2014-03-19" version="1">MAAAYADDLIVLDSGRMVAGGPASTVLTPDLVRDHFGVDGEVWSSSRRGFTWNGLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB3</accession>
    <name>W4THB3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67823">
        <property type="protein sequence ID" value="GAE67823"/>
        <property type="gene ID" value="JCM18909_909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="502" mass="52528" checksum="951850674CBCEFC7" modified="2014-03-19" version="1">MDPLTALETSTRIAAGDVGILDVVDAALEAAHADECHAWTWIDDAGARNTARELQRQLDTGQARPGPLFGVPCPVKDLNALAGAPRAVSSRAVGGMPSGHDDGIVTRLKAAGAIPIGTTAAPEFGLPCYTEPDGRAATVTPWDHTRMAGGSSGGAAAAVGAGQVPIAQGSDGGGSIRIPASCCGVVGLKPSRGRVSAGPYGVDGPGLVCGGVLTRTVRDTAAALDVLSGPWPGDPFYAPTPTETFLSACGRDTRWLRIGILREPVIADAQVHPDILAALDRTAATLESMGHVVEQTSAPFGPREWDSFRCVWEVGAAAIPVPPEREELCTPMSRWLRAGGRRRSGVELAEALAGIQMVARQVGQHWQRFDVIVSPTLAQPPLPVGALRDDEDPAADFDAQCRFTPWTSLWNITGGPAMSLPLHNTRIDGVELPIGIMIGGRLYDEATLLALGCAWKILGTANATADVQNSRLTCGGSTDMPAYGPGREFFACRSVRRHGRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE5</accession>
    <name>W4THE5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">YidE/YbjL duplication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAE transporter (TC 2.A.81) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67858">
        <property type="protein sequence ID" value="GAE67858"/>
        <property type="gene ID" value="JCM18909_949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006512">
        <property type="entry name" value="YidE_YbjL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06826">
        <property type="entry name" value="Asp-Al_Ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850735" evidence="7">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Asp-Al_Ex" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="10725" checksum="54B1EB353B367BD2" modified="2014-03-19" version="1">MIFLACVGLASGPAFLSQAVSGTGLAVIGVSAVTLVLGGAIVIAAAWCMKLSAQRATGAFAGFVGQPAILSYANSLVNDERIESAYGALFALGTVVKILLVQVIVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE9</accession>
    <name>W4THE9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68385">
        <property type="protein sequence ID" value="GAE68385"/>
        <property type="gene ID" value="JCM18909_1520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="335" mass="35353" checksum="9BC345C50FC171C2" modified="2014-03-19" version="1">MVDPGPDMPFEGHRHLHSMANLADTNSQIRSGMEEAIKQTDMHQPGVIIGSRVARKLDDLDFTLKILETTLHKAEDQRNAGITTLAGHLQSINDHMAATAGQLQDLEKYSAAVGGELSTLGTDLDSAVVSTRKAADKELTNDLTTSLEGVGSIRGRGQQAIGQMFGEFTNNLTEQSGHVAAEGERTVGLANERVESTNGHLAGQMNDVMQARSAEAKKTADGAVADTEQVSKLLSGDIARVLDDIGQHTNSGGGLLGAISTSASYLTVADDKVADANTQTHIAQSTQRTVYGNAQVDGAARRASLARLETPLTIKSHGGTVSATWMSTRIEGRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH4</accession>
    <name>W4THH4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67947">
        <property type="protein sequence ID" value="GAE67947"/>
        <property type="gene ID" value="JCM18909_1049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="231" mass="24663" checksum="2BFFA662F28B9742" modified="2014-03-19" version="1">MSENKVITVLVVDDSAVMRLGLRTLLDQDDGIEVVGEAENGDIAVRCATELHPDVILLDIRMPRQDGLSVLSQLAAGSTVIMITFTDDAGAIRRAMDEGAAGYLVHGTFDARSLGHMIRSAKAGVMPVAPMVMSALAGRGHGTEIARLPGIRRNMGLSERQAEVMDLIAAGQSNKEISKTLFLAEKTVKNHINQIFATLGVTTRAQAIVLWLQGSGPDGPERELGSAWVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR4</accession>
    <name>W4THR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67958">
        <property type="protein sequence ID" value="GAE67958"/>
        <property type="gene ID" value="JCM18909_1060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="476" mass="49984" checksum="B00646ED22E71094" modified="2014-03-19" version="1">MGAAEGVPALAVIFGKGSCAPASQAKPPAQQLPKRCLIHSDENATSIYAEGKITWVTVGGEGGYGYHLVEYSDGKADVELFYNVGVSAGAAASGWSKGPASLDASITGSAKYTKGETVHYDSVAAARADRDNLNKYARGRALAVMHLGGAPDVPNSRLSSSRTVEVDVKGKADLKVKAKIGGHGSADAGASGSVNGIVQYITKRDSKTGAVTHTVEALGSANGDAHANAGATMGNHGVKTPTVGGHAGIDDDTSVSVTKDNSGKITELVITRSGAEGADFGVDGDFKFEPGKPRLVPDPGKPRPVPGPVRWKPEPNKTRDAGNNEGRHGKQGKGSTLSKKPGHEEESDGDRKSRETTTIRVAVNDQNRSQVQKWLGGNNVGLSNAVPLLVKARFMNSLDADATNDFAKFLYQSEDTQIDTQTSSETSDLKDDSYDILVAKVGEKKMLGNPVRPPVRWVIFWRTANVSPRLVRGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS6</accession>
    <name>W4THS6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-succinylbenzoic acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67729">
        <property type="protein sequence ID" value="GAE67729"/>
        <property type="gene ID" value="JCM18909_809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12482" checksum="761B289B5B9B6A6F" modified="2014-03-19" version="1">MGFDSQPLRAYVEHDFTYVAGLERNLHRFSDSPAMIDPVADRSWTYRELAADVERFAVVLSQHGVGPGDTFAFELFNTPQFAICYLAAHRLGAVGTVLNCRLAPRRVGLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU3</accession>
    <name>W4THU3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67744">
        <property type="protein sequence ID" value="GAE67744"/>
        <property type="gene ID" value="JCM18909_825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6845" checksum="BEBBA1BE45BC4D75" modified="2014-03-19" version="1">MLTEFGAITTPAVITSQMDLAARNRVGVQWWAYTAGDPTTAGPGTEQASSTTQLGHPRGPTSKAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV5</accession>
    <name>W4THV5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67754">
        <property type="protein sequence ID" value="GAE67754"/>
        <property type="gene ID" value="JCM18909_835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10979" checksum="BA5C6A07D138EB9C" modified="2014-03-19" version="1">MTSFEPTPGVEVHALLRSTRLDLAQRILGTRMANVTYTEDAWTLITVRYPDVESVRQLLYLGDHIRILNPAEAVEQFHDLAAQIMRAHSTNSSTNVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW7</accession>
    <name>W4THW7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen III decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68018">
        <property type="protein sequence ID" value="GAE68018"/>
        <property type="gene ID" value="JCM18909_1124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14406" checksum="5A2B50FF02B0FC03" modified="2014-03-19" version="1">MSDYRASAAPFSQRALATVDPNIPVVHFGVNATHLLSEFAQVAATASRYPVLGVDHRISLDEACATLMVSGMEMPVQGNIDPALLFAGWEPLESATRDIVAAGRQAPGHVVNLGHGVPSNTDPNVLTRLVELVHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX1</accession>
    <name>W4THX1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68023">
        <property type="protein sequence ID" value="GAE68023"/>
        <property type="gene ID" value="JCM18909_1129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="338" mass="37048" checksum="7DAA574C3BAB35B8" modified="2014-03-19" version="1">MTANPYAAPTDPLAPYGAVLVVSFGGPRSPEEVMPFLRRVSHGRIPEERLADVARHYDRFGGVSPINDATDVFVNAIGNELRHHGVRVPVLLGNRNGTPFLEEALTDMHAHGVRRVLAVVTSAYASYSGCRQYREEIAIALAHAGITDMQVDKVPPFNEAPGFIRANAEALMQAFMRIPPTPLEATRVVFVTHSIPDSMQDASGAGRPGTDYISQHKAVCERVAGQVRQVFGNMPQWDLAYCSRSGRPNDPWLEPDIIDHLRNLPEQACNLLSSLQLASLLTTWRSLMTLITRLPRQPRCPGSPSRGRRPLAPIPPLSLISPGSSCPRPRRLVVRGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ6</accession>
    <name>W4THZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67789">
        <property type="protein sequence ID" value="GAE67789"/>
        <property type="gene ID" value="JCM18909_872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="87"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="441" mass="46772" checksum="A314B8E44300AF99" modified="2014-03-19" version="1">MISVPALMAINFGFGLLMARAGWVGVADVLTCSLIALVLPHTVEVLGSTAWMYQQAGGAALRLQEVLSIEQIDEPGTSSAIPEDTTVTFDDISVSYHTPDGEVPALNHVSLTLRPGTVTALVGPSGSGKSTLATMLARFRDPDFGTVRIGGVDLRELPSTDLYRLVSFVLQDPYLQRQSIRDVITLARPDATEQQVRDAARTARILDDIDALPAGFDTVLGEDTNLSGGQKQRLSIARAVLADAPILVLDEATAATDPDCEAEIQQALAALARGRTVLVIGHHAESVIGLMSSASWRTALSQPAAPPSNWPNSPTGCGCRRDESWRESPDEHHVVTSFLGRGHPPGAGVPTIADQRGHPAVPQLLGVGRCVRSDRGSRPVCRHPDVHRFRCGAALVGSCLVGLGVGARCPGCCRGCGVVPSVEHGVSMCDRHPESPQHPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ7</accession>
    <name>W4THZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal recognition particle, subunit Ffh SRP54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68147">
        <property type="protein sequence ID" value="GAE68147"/>
        <property type="gene ID" value="JCM18909_1266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="99"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="4">
        <location>
            <begin position="100"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23226" checksum="2EFBA4A821E064BC" modified="2014-03-19" version="1">MFDTLQDRLASTFKGLRGKGRLTDADIDATTRQIRIALLEADVNLSVVKEFVAAIKERCHGEELSKALNPTQQIVKIVNEELVEILGGQTRTVRFAKTPPTIVMLAGLQGAGKTTLAGKLARWFKEEGHSPLLVACDLQRPNAVTQLQVVGERAGVHVFAPEPDNGVGDPIQVARDAVAEAEHKLYDVVIIDTAGRLGVDAEMMAQAADIKLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI09</accession>
    <name>W4TI09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68585">
        <property type="protein sequence ID" value="GAE68585"/>
        <property type="gene ID" value="JCM18909_1732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5844" checksum="34B1E0AA3B8BC7BD" modified="2014-03-19" version="1">MEELGKVHEPPLTKDAIAGRIRRLLALADKTARSNGELTTLESLPAEMRDDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI21</accession>
    <name>W4TI21_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68600">
        <property type="protein sequence ID" value="GAE68600"/>
        <property type="gene ID" value="JCM18909_1747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="3964" checksum="7FADF5CD84D7FC20" modified="2014-03-19" version="1">MTGAQPWCGEPDAEAIEATTGVTCRTMWTVICSVSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI41</accession>
    <name>W4TI41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SSU ribosomal protein S1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68625">
        <property type="protein sequence ID" value="GAE68625"/>
        <property type="gene ID" value="JCM18909_1773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="136"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="221"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="408" mass="45756" checksum="006BC04992CA6F3A" modified="2014-03-19" version="1">MDPFEVVNVGDEIEALVQQKEDKEGRLILSKKRAQYERAWGTIEQVKEEDGVVTGTVIEVVKGGLIVDIGLRGFLPASLVEMRRVRDLQPYVGQEIEAKIIELDKNRNNVVLSRRAWLEQTQSEVRQNFLHQLQKGQIRKGVVSSIVNFGAFVDLGGVDGLVHVSELSWKHIDHPSEVVEVGRPVTVEVLDVDMDRERVSLSLKATQEDPWQAFARLHQIGQIVPGKVTKLVPFGAFVRVEDGIEGLVHVSELAERHVEIPEQVVSVNDDVMVKIIDIDLDRRRISLSLKQANEGIDVESDEFDPSLYGMAASYDEDGNYIYPEGFDPETNEWKPGYDEQRIAWEQQYAEAQARWEAHRKQVIEAEQADQEAALTDGGAQSSYTSGPAEGSLASDEALQALRDKLTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI88</accession>
    <name>W4TI88_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-ornithine 4,5-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68476">
        <property type="protein sequence ID" value="GAE68476"/>
        <property type="gene ID" value="JCM18909_1617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015130">
        <property type="entry name" value="Lys-AminoMut_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16552">
        <property type="entry name" value="OAM_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lys-AminoMut_A" evidence="2">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15130" checksum="0475C9829FB0C05A" modified="2014-03-19" version="1">MSDLDQERVERYEALRTELADLDDAALKERFWQLCEEVMTPVVDLARTHTTPSIERSVLLRMGIDSVTTHAVVENVFAAGLGGKGAGHAVLRLSRRDGIGLRDAAARIAEDPKALDELFDGSPLPPAKTSTTDSKEGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI97</accession>
    <name>W4TI97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68257">
        <property type="protein sequence ID" value="GAE68257"/>
        <property type="gene ID" value="JCM18909_1381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10333" checksum="8013DA0029BD932F" modified="2014-03-19" version="1">MLEEVQLVPQSGQFPGTLSSGQRRRLGLATALVRPRKLLVLDEPEARLDVEGVAWLGKRLREEMNHGLAIVMASHEPALVETLGARTVELGGPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB5</accession>
    <name>W4TIB5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galacto-N-biose-/lacto-N-biose I ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68506">
        <property type="protein sequence ID" value="GAE68506"/>
        <property type="gene ID" value="JCM18909_1649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30569" checksum="489F525ABEEE4C70" modified="2014-03-19" version="1">MYVKGLVQDVTNEAEKYKGHFSGAYGQMSVGGKVVGLPQDTGPLVYVYNEAEFKKLGIGVPKTSSELLSSAKKAAAKGKYILGFEPDEAQNWLSAQAAAAGAVWCSAEGDKWKVDTNGDKSKVVADFWQKALDDKSAVTDARWSDAYTKDLVSGKLIGNIVAAWETGFMLDALDKTSYNGQWRVVQLPSFGGSDMTGPDGGSGVAVVKGCKYPAQAMQFNDWFNTQVNDLATQGLVPAAKGQVTTPEKMKKQFGGQDVMAELAKANERLAPKFGISLASLSWARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC4</accession>
    <name>W4TIC4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68516">
        <property type="protein sequence ID" value="GAE68516"/>
        <property type="gene ID" value="JCM18909_1660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014065">
        <property type="entry name" value="tRNA_adenylyltransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02692">
        <property type="entry name" value="tRNA_CCA_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="275"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="493" mass="55600" checksum="81835037C91B344E" modified="2014-03-19" version="1">MLPAALRPSPDESGMTVPQLLEHRINALFEQIPLVAELGEAFAQAGHDLYLVGGSVRDALMGRLGHDLDFTTDARPDDTEAILRQHTHATWDIGRAFGTIGAQIDDWVVEVTTYRADAYHPDSRKPEIVYGETLKEDLIRRDFTVNAMALHAATRTFSDPYAGLTDIVSGVLRTPFPPERSFSDDPLRMMRAARFTSQLGFTVTNEVRAAMTDMASRIEIISAERVRDELSKTLLTDYPREGLDLLVTTRIADYVLPELPALRLERDEHHRHKDVYEHSLTVLDQSIDLEKRRGHDPDLTGRLAALLHDIGKPSTRKFEPGGKVSFHHHDIIGAKMARKRLKALTYPSQVVKEVSKLVELHLRFHGYGDQGWTDSAVRRYVRDAGDQLERLHILTRSDCTTRNRRKAERLEFAYDDLEARIANLTAKEELAAIRPDLDGQQIMATLGIKPGPEVGKAYKFLLNLRLDEGPHTPDEAKKTHCWPGGPRRIAKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC9</accession>
    <name>W4TIC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68287">
        <property type="protein sequence ID" value="GAE68287"/>
        <property type="gene ID" value="JCM18909_1411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17173" checksum="96331A6BE01B8D92" modified="2014-03-19" version="1">MSFPILTVIALLPFVGGVITMMLRGAAARATGMVFSLVALVLGVYAFIVGVNGTNLSETHRWIRAVGAWYALGGDGLSLTMILLVVILVPVVLLAEWHVGDDETARWSTGAFFGLASCLRDWQSIASLPPTSCCSTSCSRPPSSRCTSSSQDGAVHDEAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE2</accession>
    <name>W4TIE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68302">
        <property type="protein sequence ID" value="GAE68302"/>
        <property type="gene ID" value="JCM18909_1430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15207" checksum="2799DEEFFF0F5B96" modified="2014-03-19" version="1">MSRPSHFTAPSPSKRRPLRTLSRLGVGGLLTYAGVGHLTFVREEFQAQVPDWVPVDDDTVVWLSGAAEIILGAALLSGRHKKFWGRSAAAFFAAIFPGNVGQLVEHKDGFGLDDDRKRAIRLLFQPILVGLALEGTRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK1</accession>
    <name>W4TIK1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67949">
        <property type="protein sequence ID" value="GAE67949"/>
        <property type="gene ID" value="JCM18909_1051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5499" checksum="98302F8D80128022" modified="2014-03-19" version="1">MRSVPALAKRGIAITATKSKTNVNDKRRAVLACPSSSLRNTNSPIPDTFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS8</accession>
    <name>W4TIS8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Argininosuccinate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68417">
        <property type="protein sequence ID" value="GAE68417"/>
        <property type="gene ID" value="JCM18909_1552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASL_C2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11992" checksum="9B131E93E7803ADE" modified="2014-03-19" version="1">MAGQGFSLATDVAEWLVRQGVPFRVAHELSGACVREAESQNKELADLTDQELAVIDPRLTPQVREVMTVEGSVRSRAGRGGTAPERVTEQITELREAIAGLRSFGEVETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY5</accession>
    <name>W4TIY5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WhiB-type transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68905">
        <property type="protein sequence ID" value="GAE68905"/>
        <property type="gene ID" value="JCM18909_2077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="38" mass="4569" checksum="B4465CFAAC069A35" modified="2014-03-19" version="1">MTERERRRLLRERPDVTSWRDVLLADRGTLTKTARVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ04</accession>
    <name>W4TJ04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68910">
        <property type="protein sequence ID" value="GAE68910"/>
        <property type="gene ID" value="JCM18909_2083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24436" checksum="772461B1F3BF609B" modified="2014-03-19" version="1">MIWVFIYSTALTNDSASFLHSFGVTKTVWSHNPFYGLVIICIMVAIASRAEKILFRISTVMVLTKLSVVTFLGLAIIGSWNLANVGAFPSLGYLVKQTIVMLPFTLTSILFIQSLSPMVISYRAHYKSIEVARHKALRSMNIAFSVLFITVFFYAISFNLTMGHDVAVKAYNQNISTLAMVAQGMGGTTVKIFSLILNIFAVMRRTSGCSSASVRHAKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ64</accession>
    <name>W4TJ64_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">JCM18909_1729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68582">
        <property type="protein sequence ID" value="GAE68582"/>
        <property type="gene ID" value="JCM18909_1729"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="259" mass="27498" checksum="E63B0D39865B6970" modified="2014-03-19" version="1">MSRTPIMAGNWKMNLDHVAATSLVQDLGEALKAAGYDSSKSEAVVIPPFTDIRPVAIIIDGDKLPIAYGAQDISAHDDGAYTGEVSGTMLSKLGCRYVVVGHSERREYHNESDELVNAKAKKVIENGMTPIICCGEALEVRKAGKHVEHTVGQIKADLDGIPAEQVAKLVIAYEPIWAIGTGETATADDAQEVCQAIREAVKELYDAPTAEAVRIQYGGSVKPANVAEIMAKPDVDGALVGGASLKAGDFSKIVTFYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ98</accession>
    <name>W4TJ98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68861">
        <property type="protein sequence ID" value="GAE68861"/>
        <property type="gene ID" value="JCM18909_2029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8008" checksum="DF4549EFA21DB7B6" modified="2014-03-19" version="1">MISAGKTDAATFTTIKNDIKAKGPSYCTPKNVGGCAKVTITLLAAGESPNYGGTDYAGPVTSRLSSLSIRRIRRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA3</accession>
    <name>W4TJA3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68866">
        <property type="protein sequence ID" value="GAE68866"/>
        <property type="gene ID" value="JCM18909_2035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7062" checksum="81A8C1743DDB44FD" modified="2014-03-19" version="1">MASIPSLLDDEYADTLFTIAYSAPVAGKATGAESSPTPEPPDPPRPLGSGKPGFPPWVVGAPERPAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB8</accession>
    <name>W4TJB8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68249">
        <property type="protein sequence ID" value="GAE68249"/>
        <property type="gene ID" value="JCM18909_1372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8444" checksum="BF84326AFDFB5B71" modified="2014-03-19" version="1">MGSTPLVSPVVGWIGNAIGPRATVTWGAISLGITFVVITAVIMHNDRIRVVFDPSKRAPWLRQVRGKVTIDYVQQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD3</accession>
    <name>W4TJD3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69060">
        <property type="protein sequence ID" value="GAE69060"/>
        <property type="gene ID" value="JCM18909_2242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="2">
        <location>
            <begin position="43"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="14936" checksum="E33AA75FEC12378D" modified="2014-03-19" version="1">MICRGRHRWVFATSNQGLSTPAVYRRFDELGGTPGGETVPNDLLSALTRGDLDAVAASLSNDLQAAAIDLRPELEEVLTVGREVGALTALVSGSGPTCAFLVRDTAGAKKVSAAVSTLPQVHRTRTARGPAAGAQLLPGPVGSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM3</accession>
    <name>W4TJM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68971">
        <property type="protein sequence ID" value="GAE68971"/>
        <property type="gene ID" value="JCM18909_2149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="3"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="236" mass="24486" checksum="D77CF9AD9CDA8198" modified="2014-03-19" version="1">MLALIALGVVFTLNMLSVKMFGEAEFWFAAIKVAAIILFMIAAIWAIVTGARVGNYTAGFHNIAQHGGFFPAGLAPVFALTLGVIFAFGGTEMVGVAAGETKDASKILPKAINSMILRIFVFYVGSIILMALVLPYTAYSSNESPFVTFFTGIGIPYAGDIIQVIVLTAALSSLNAGLYSTGRTLRSLAVAGEAPKAAAKLNRHHVPSGGIAMTAALGLLGVASTPSSRIAPSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP8</accession>
    <name>W4TJP8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69180">
        <property type="protein sequence ID" value="GAE69180"/>
        <property type="gene ID" value="JCM18909_2371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="241" mass="25267" checksum="14DD3BDAF57F3C14" modified="2014-03-19" version="1">MSVTVLSLQSHVVQGTVGNSIAVPVMRAMGVRAWGMPTALLSNHNGRSSVAGIPIDSEQIDAMVNALDSNGELKHVDAVLSGYLTPRTGPAVLRTVERCRALHPDTIWVCDPVMGDMSPDGELRAYVPDETVSLMTGAVQHADVVVPNLAELGILTGTEPRTLDEIVRAARSLTGPHLVIVTSVPYHDDSGDGIAMVGVTGERAVLTHGPLFDRHFNGAGDLTSAVLTAVGERGATGCHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR6</accession>
    <name>W4TJR6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DeaD/DeaH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68777">
        <property type="protein sequence ID" value="GAE68777"/>
        <property type="gene ID" value="JCM18909_1934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15157" checksum="CA5475B94C5FDBC0" modified="2014-03-19" version="1">MLALSNALILRRPPDQTVIRGTQPLEESPAEPTHTVGTIDITQTPWPTVIENLGSSLATPELPELLEDLAAQGVSEPTAGEEIGSEGIMVDLAWPESRIAVIFAPEPDDEDLLAEDGWTLVPPTAHDITAALANTTKGEGHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT1</accession>
    <name>W4TJT1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68688">
        <property type="protein sequence ID" value="GAE68688"/>
        <property type="gene ID" value="JCM18909_1839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5531" checksum="3DE63AB662387602" modified="2014-03-19" version="1">MRVLDVVTLAQWVEAAPINDSAQVGPDVVIDTRKVTPGALFIALPGTRRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK64</accession>
    <name>W4TK64_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="13" type="ORF">JCM18909_2551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69345">
        <property type="protein sequence ID" value="GAE69345"/>
        <property type="gene ID" value="JCM18909_2551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE69345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21390" checksum="18BEF2AE9E44440A" modified="2014-03-19" version="1">MIISSRTRTVLVGLRSMLLFTVIVGVVYTGLLTGLGQLVLHHQANGSQLEVNGKVVGSTLIGQSFTDKGGRPLPKYFQPRPSAAGDDGYGARSSGGSNMGPENPDLAKAIKERRSQVAAFNHVDADRVPADAVTASSSGLDPHISPEYANIQIARVAKARHLGKAVVRRIVDDNTTGRQLGFLGETKVNVVTLNAELDRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB5</accession>
    <name>W4TKB5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic glycerol-3-phosphate dehydrogenase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69241">
        <property type="protein sequence ID" value="GAE69241"/>
        <property type="gene ID" value="JCM18909_2436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009158">
        <property type="entry name" value="G3P_DH_GlpB_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03378">
        <property type="entry name" value="glycerol3P_GlpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="21"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="481" mass="50872" checksum="A158A2FCBBCE13BB" modified="2014-03-19" version="1">MSTATVSTQSVTADRFGAQHVVVGSGLAGLTTALRLRRGGARVTLVTKGVGGLQLGQGTIDILGYTPDRVEKPYQAVQEFASQHPAHPYAKIGVEAVKEGIDFLREIVGDSYLLGDGETTINVPTAVGAIRPTALVPPSMINGNLKDGDKAVVIGLAQYKDFHAGLIAQNINRTTLPGGGHASARAVVVDFEPREGEYDATGLAIARSLDDARTRRMLAEGLRGFVNPGEIVALPAVLGIDNHSEVLADFKKILGAEVFEIASLPPCVPGMRLNNKLVVTAKNERVDYVLGSKVTGCTVADGKVVSVTVGTAGAGKEIKADAVVLAGGGFESGALKLDSHGHLHETILDLPVTMPEGVKKEDLIHGDYWGSPQPLFLCGVEVDETMLVTYQGKPVHSNVYAAGGVIAGATRWQEKSGEGIALGSAIKLPMPSCRRSGQAPRPRKGTDHGCYRGDIRRTRGLAPVARRLRKMYYLRDDVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG5</accession>
    <name>W4TKG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-carnitine dehydratase/bile acid-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69291">
        <property type="protein sequence ID" value="GAE69291"/>
        <property type="gene ID" value="JCM18909_2491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="388" mass="41898" checksum="E4C9EFA633C15B94" modified="2014-03-19" version="1">MSKGVLEGVRVLDLSRVLAGPYCGAFLADLGADVVKVEAPNGDDARHLGPFKGEESVYFAELNHGKRSVVLNFKDPKDHERFMKLVEHADVVLENFRPGVTKRLGVDAESVHKTNPRIIYASISGFGQEGPFRNRPAYDLIVKAMSGIMAATGPEGGKPTRVGESLGDVVSGIFAGWAICAALYERECTGVGRTVDVSMFNSLLALQVTNLSLLLADGKLPGRIGNRHPVSVPFDTYPAKDGLVALAVANDRIWARLADLMGRPDLGTNDAYLGDMNRANKRQELTQLVSGWTQTMTVAELLRKTEEAGVPAAPIWDLKDALESEHVVARHSLGHFTHPELGKMPYLRFPADFGCGGLEVSSEPSPRLGDQTAGAVVAEWGRSANDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ8</accession>
    <name>W4TKJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69321">
        <property type="protein sequence ID" value="GAE69321"/>
        <property type="gene ID" value="JCM18909_2523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="291" mass="31760" checksum="EFA8816FABE667ED" modified="2014-03-19" version="1">MFRSAEPGRTARQVLSGLYWGAILVWLIGMGEIVTGVKLLPLLYPRANTLGAVSKNRWVVTATYPNYNDYGVVMAMLFTAVLARLWFNPRRGAIRLGRLFVLATCLVMILIGGSRGALFGCICAVMLLFVLNVRRLHTAAMGVRAFVWGGALVIVLGTGLWMSPYVQDHSTAERGTIMANALSMTLSNPAALLLGYGSLSEYQARASALYGHVLMDPHNLLLEIVLRYGAIAMILFVVCWLWILVRGFLPRRPVADWRAAFGLTVVMLFPVLGVVPSSTAVSRDLALPCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW1</accession>
    <name>W4TKW1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein 60 family chaperone GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69590">
        <property type="protein sequence ID" value="GAE69590"/>
        <property type="gene ID" value="JCM18909_2824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6607" checksum="FB53F92A282B9CEF" modified="2014-03-19" version="1">MVREGLRNVTAGANPMGLKKGIEPPSRLLVLVCPTWPSTSRPKTRSPLPPPSRRRPHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL83</accession>
    <name>W4TL83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arogenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69203">
        <property type="protein sequence ID" value="GAE69203"/>
        <property type="gene ID" value="JCM18909_2396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11379" checksum="2D4FE7B3C3A34735" modified="2014-03-19" version="1">MREGTDVHLWDIDRDNSLIAAGHGAGRLDNLADDAYQMIVIATPPAVVAQTVVERLTRHPQAVVTDTTSVKGAVLAELTTLATEHGIDISRYVVPTPWPEPSTPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG9</accession>
    <name>W4TLG9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68999">
        <property type="protein sequence ID" value="GAE68999"/>
        <property type="gene ID" value="JCM18909_2178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15453" checksum="C83B2F6A2DDC1C15" modified="2014-03-19" version="1">MKKDYFNRTQKLVTVLIDATVFVVGIFLSFWMRFGMVIPQRNLDDGKAALMASVIAFLIINVLSGVYVLYNKTLLDIGIITVVDQVMVTIVIMALTFFGRWFASRVRSSSLTWWLASSCSLCGAVSRSWPIAVCEGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH0</accession>
    <name>W4TLH0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein 60 family chaperone GroEL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69591">
        <property type="protein sequence ID" value="GAE69591"/>
        <property type="gene ID" value="JCM18909_2825"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9247" checksum="508A62C0E257ED4F" modified="2014-03-19" version="1">MAKLIEFNIEARRGLEAGMNTLADAVKVTLGPKGRNVVLEKVVGRSHHYQRRCLHRQGDRARRSLRENRRRARQGGRQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI5</accession>
    <name>W4TLI5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69377">
        <property type="protein sequence ID" value="GAE69377"/>
        <property type="gene ID" value="JCM18909_2586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="285" mass="31031" checksum="3A9F3A76AE873CFD" modified="2014-03-19" version="1">MSDDDCPQAQAQIWSVDGQGHDLRQHTHHGEAEGYVRDPRTDGTTIVYHTHGALWRMTGLDTEPERLEIDLGIGAPPRMPLDPTDRLEAVVSDHGADGSLLEWRGAAYFLTHRSGPARALSAADGVRIREPRVLGQTGQGVWASDVDGEDCLEVANLDGTGEIRRIAQGQIGRVLHIAPAPDGTKVALISHDGRILIVTIADGAIREIGKSLEGEANWLAWSPDSRYVVWRSPMATGEAMIGQIRCWDEQGMGEPFELTRGAFDDSCPVFTADGKYLAMLSARTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL8</accession>
    <name>W4TLL8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter associated permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69641">
        <property type="protein sequence ID" value="GAE69641"/>
        <property type="gene ID" value="JCM18909_2884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6339" checksum="366FFE086D0DC45D" modified="2014-03-19" version="1">MALTAAGVSPVAMSPVPLADVLEQGAWFPLLLLAAVPLGCLPRTIASVKSHKPYELLREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP6</accession>
    <name>W4TLP6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69676">
        <property type="protein sequence ID" value="GAE69676"/>
        <property type="gene ID" value="JCM18909_2921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="12012" checksum="4612A0898CF2E38F" modified="2014-03-19" version="1">MCALHEGTAILPREGQDDIVVEPDDIDHFGNRRLRTVGELIQNQLRTGLSRMERVVRDRMTTQDIEAITPQTLINIRPVTAAIKEFFRNLPAVAVHGSEQPAGRDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM51</accession>
    <name>W4TM51_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsR</name>
        <name evidence="6" type="ORF">JCM18909_2468</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TM51"/>
    <dbReference type="EnsemblBacteria" id="GAE69269">
        <property type="protein sequence ID" value="GAE69269"/>
        <property type="gene ID" value="JCM18909_2468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8797" checksum="AF5FAB37EC27CCA6" modified="2014-03-19" version="1">MAGPQRKSVNKKKVVPIKTVHIGAVDYKDTALLRKFISERGKIRARRVTGLSVQDQRKVAIAIKNARELALLPYASTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH2</accession>
    <name>W4TMH2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69389">
        <property type="protein sequence ID" value="GAE69389"/>
        <property type="gene ID" value="JCM18909_2598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11907" checksum="FF6DA5FCC6215511" modified="2014-03-19" version="1">MTSQTFTTSSATPPTRGVVPDKPALEGLEVKWGKTWEDEQLYAFDATAVDSREQVFSIDTPPPTVSGHLHPGHVFSYTHTDTVARYQRMRGKKVFLPDGLGRQRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML9</accession>
    <name>W4TML9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69419">
        <property type="protein sequence ID" value="GAE69419"/>
        <property type="gene ID" value="JCM18909_2629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13829" checksum="194108440522EF13" modified="2014-03-19" version="1">MHQLGLESTQAYEGGRERLARFIGAARPEEVVALSNASEALNLCAYTLGERLGPGDEIVISVMEHHSNVVPWQIICQRTGATLRWFDITDDGRLDLEKAEAEGLINGRTKVVSLALASNVLGTINPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ8</accession>
    <name>W4TMQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69827">
        <property type="protein sequence ID" value="GAE69827"/>
        <property type="gene ID" value="JCM18909_3083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="96"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="289" mass="31984" checksum="08CB5AEF2B73D349" modified="2014-03-19" version="1">MKDIDWRTVVSLRRKASERISSERASHRERTGVDLSGDDVRMLGRSIMRQAVESHAEKLTAEGQALWSAQTKDAYVRAVMDAIFGYGRLQPLFEIQDAENIEINGCDRVFVQYGDGRREPGPVVADDDAELVEAIRFLGESANPPRPFDDAHPTMTVALGSQYRLHAIGFGLSYRPSVVIRHHTLTRVTIDDLVNTAMMPHHVGVLLRAAVLARRSIVIAGDQGAGKTTLLRALVDAIPPTERFGTLETDYDLLTHLNPDRDNMVAFQATVGLREKVDGHCLGEFTVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN11</accession>
    <name>W4TN11_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70365">
        <property type="protein sequence ID" value="GAE70365"/>
        <property type="gene ID" value="JCM18909_3681"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7524" checksum="74B54FFD941CFB43" modified="2014-03-19" version="1">MLREAVTNVVRHAQAHTCFVEIDDEILAISDDGCGRGGAPEGNGLTGMRRRVEAAGESCGSGRGNVVTVPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN33</accession>
    <name>W4TN33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69823">
        <property type="protein sequence ID" value="GAE69823"/>
        <property type="gene ID" value="JCM18909_3079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="227" mass="24343" checksum="F412035F74B2AC8A" modified="2014-03-19" version="1">MVSERSRRTLILQGRTPGDLVIEKAVMAMGGMLVPALARAVAAACGDTLPVTPVGLAVILAVVGWFIPDTRIRSRSKAVRQDAAEAVLVYVDLVTLARLANQSAPRALVEAAQMSDHPVLARIRMTLELSRLEQQSPWAGLDGLSDELDLPELAELVEVLRLDDQGASLAGALRARVHEMRDAHLNQEKAEAQTASESLTIWMVIPVLVLGLVLITPPLLIMVGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN49</accession>
    <name>W4TN49_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-nitrophenylphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69942">
        <property type="protein sequence ID" value="GAE69942"/>
        <property type="gene ID" value="JCM18909_3212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="332" mass="34778" checksum="D83BE52ABB44C63D" modified="2014-03-19" version="1">MSDALIDGHDAALFDLDGVVYLGPDPVPAAPDTIAELRRRGVKVGFVTNNAARSAEVVAQHLTDIGIPTGPSDVVTSGQAISDLAADTLPAGARVLIVGTESLRDEARARGLQPVESARDDPVAVIQGYDSQIAWPLLEEAGFALQAGAMWYAANPDITRPTDRGIVPGIGAQLQVVATMCNAEPVIAGKPYRPLLEATISRLGSTSPIFVGDRLDTDIRGANTMDIDSLFIFTGSHGVADVLAAAPEDRPQNIAADLSGLLEPKREVDVSGDRARCGGSIVSMHADREVRVEGTPDDICGQLDAVAAMMALVYGSNVAIPDDAGRLFDKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA9</accession>
    <name>W4TNA9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thymidine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69893">
        <property type="protein sequence ID" value="GAE69893"/>
        <property type="gene ID" value="JCM18909_3159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="2">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12483" checksum="032793BD675173F2" modified="2014-03-19" version="1">MIRAQGGDPDAPLPVAHHSQDIVATEAGVITGIDAMSVGLAAWRLGAGRARKEDPVQAAAGVMLRVRPGDRVVTGQPLATLLTDTPDSIARAEDAMTNAFTVGQTFQPQDIVIDTVVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN1</accession>
    <name>W4TNN1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminodeoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70341">
        <property type="protein sequence ID" value="GAE70341"/>
        <property type="gene ID" value="JCM18909_3655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="240" mass="25191" checksum="96A658EED3DF14A0" modified="2014-03-19" version="1">MNSSVPYLLAILGEGVVSPSTMVCHADDLGLVRGDGVFDTTRIVTAQDGTSRIDHLDEHLSRFARSIAGVGGPTPDLDSWNHLIEEAARTWRIPGEAALKLVYTNGRQVVPGPPRGFLIISPLSETAIEEREGIDVLCLSRGVTSDAFADAPWLLGGVKTLSYAVNVAALRYARSQGADDAIFTSTDGYLLEGPTSGLVIAADDSLWTTPTGTTGILSSITVSTVFEATGEVGVQTSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP7</accession>
    <name>W4TNP7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70018">
        <property type="protein sequence ID" value="GAE70018"/>
        <property type="gene ID" value="JCM18909_3298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="250" mass="28111" checksum="FDED99BA6AFF8F1E" modified="2014-03-19" version="1">MPEKKRRQIRGEHISMIFQDALSSLNPVFPVGWQIAEMFRVHRGMNRSDSMSETIRLMERVHIPAAKERANNSPHQFSGGMRQRIMIAIAIALNPWVLIADEPTTALDVTVQAQIMTLLKELQEESGMGLILITHDLGMVADVADDIAVMYCGQFVEHADVRRLYDNPAHPYTVGLLDSIPRLDQKGHELYAIGGLPPSLTNLPSGCSFHPRCRWATEECRVGGAPTFVEVEPGRWAACHHTEEVLRRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU8</accession>
    <name>W4TNU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Plasmid partition protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70640">
        <property type="protein sequence ID" value="GAE70640"/>
        <property type="gene ID" value="JCM18909_4000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17366" checksum="D7A81DEB391DA245" modified="2014-03-19" version="1">MVQWAPVVGVFVLLADLPAVVAGGSFCMLARRSDALMQMCNDADMPRVISIVNTKGGVGKTTTAVYLATALSCQDRVVLLDADPQGSATSWATDAFEAGDRLNFEVRPANAPIVRRCRDIDADLVIIDTPPGDSQTITAASRLLMWLLSRLSRGTWIWTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV9</accession>
    <name>W4TNV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70227">
        <property type="protein sequence ID" value="GAE70227"/>
        <property type="gene ID" value="JCM18909_3525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="41"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="28954" checksum="B7BBAF25022F30BC" modified="2014-03-19" version="1">MAMTGGPNDDYLGWDRISKGSLRSARRLSSRRGRDESGLFLVEGAQAVREALAWPGKVNLLATSDPVRDAEHVEVAKCRGVRVAVLTDEDVNALSDTVTSQGIFAVCRQVTRRELPDEAVRLAVICAQVRDPGNAGTVIRCADAFGADCVILTRGSVDPHNPKTVRSSVGSIFHLPVVVGVELADAVEWAHQHQMSVLAADGGGHSLDVVARSGCLKRPIAWLMGNEAWGLPEAARALADEIVGVPMWGAAESLNLSTAAAVVLYATASEQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX8</accession>
    <name>W4TNX8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosylamine-glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70406">
        <property type="protein sequence ID" value="GAE70406"/>
        <property type="gene ID" value="JCM18909_3724"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GARS_C" evidence="2">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="14706" checksum="B2839EAC7F9817D3" modified="2014-03-19" version="1">MAQIMAAAARGDLSGVDGLRFRCGAAVGVVMASEGYPACPAKGRRVVAPVDDEDVLHAGTRIEGDGLVTSGGRVLVVLGHGETLAGARADAYRRIDQLEVSDGFHRTDIARHAAELEAVDEMVDGCAPQSENSTNLTDGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP02</accession>
    <name>W4TP02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70143">
        <property type="protein sequence ID" value="GAE70143"/>
        <property type="gene ID" value="JCM18909_3439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13864" checksum="45D90B1DDF03D2E7" modified="2014-03-19" version="1">MRAGAGIPQCELPAPSGEIITTRTVENSPHRIVLYLPDGNGHSQGFFFDDNGHTDSYRQGHGYWLTWIADYTGTTVTVHTHVEGDYQPSWGTMAFALRSGDDRAIEVVTDAARDQKPNTTIERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP84</accession>
    <name>W4TP84_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70526">
        <property type="protein sequence ID" value="GAE70526"/>
        <property type="gene ID" value="JCM18909_3859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7086" checksum="0C203D74A8108798" modified="2014-03-19" version="1">MLLATSAGTPYVPMSVRFQPNQLVLNISLRDLHPETIRTANNVFDDVEHCLKANTTPHLLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPE7</accession>
    <name>W4TPE7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70596">
        <property type="protein sequence ID" value="GAE70596"/>
        <property type="gene ID" value="JCM18909_3946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="24620" checksum="A4021C6F9E124108" modified="2014-03-19" version="1">MSKVSFSPGMMGAMADMAVPDEIIEARDGRPEIIIRRSARRRRTLSARMEGSSVLVMVPMGMRKADQDRQVMELVDKVTKSDARRRHHDSNDELTRRALRLCQKYLDPRVNDTVEPASVRWVSNQNTRWGSCTPSTGQIRLSDRMIGFPDWVVDHVLAHELCHLVEGHHNRRFHELLAGFPNAERAEGFLTGFQWAVSGEADNTRNDPDDNPADQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPH7</accession>
    <name>W4TPH7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70114">
        <property type="protein sequence ID" value="GAE70114"/>
        <property type="gene ID" value="JCM18909_3405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8855" checksum="FE9514217A296117" modified="2014-03-19" version="1">MPNLDIVAAVQIGNEGVFSDAAKPTDHPRCSPVSGIDQVLSTFSNVFADVPVKRYINLPLPDPSIANHLAYDWWVTRFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPJ9</accession>
    <name>W4TPJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidinol-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70427">
        <property type="protein sequence ID" value="GAE70427"/>
        <property type="gene ID" value="JCM18909_3745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15505" checksum="B247F116294E14AD" modified="2014-03-19" version="1">MRRALSRMRSRDAVHGEERADTGDGPRRWIIDPIDGTANFLRGVPVWATLIALSVEDQIVASVVSAPALKRRWWAARGSGAWSGKSLASATPIHVSNVRNLADAFLSYSSLHGWVESGRGHGFGKLMRSVWRTRPSAISGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPN2</accession>
    <name>W4TPN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lacto-N-biose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70472">
        <property type="protein sequence ID" value="GAE70472"/>
        <property type="gene ID" value="JCM18909_3799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035080">
        <property type="entry name" value="Lact_bio_phlase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012711">
        <property type="entry name" value="Lacto-N-biose_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09508">
        <property type="entry name" value="Lact_bio_phlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02336">
        <property type="entry name" value="TIGR02336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lact_bio_phlase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="494" mass="55992" checksum="CA9080B4C282624B" modified="2014-03-19" version="1">MDAQVTELLERLQADAVRNSDGTELPEIVNKLATKIYQTYFVGRGDQDWAQTHPRELTRIYLMSERTPALADGELSIDLMTNWFVDQVYPDTDCDVERWWQVIDRTTGDVIAPGAWHVDPAGLSVTMDQAQAGHVYTVGFLAVQRWDPTQMYNYLTNGWADDPQRIKESPYDIRYPQTWQHVRHALDQWLADNPQVDVVRFTTFFYHFTLVYGSDGTERFVDWFDYSASVSVPAMEAFEKRFGYPLQAEDFIDEGWYNSPFRVPRKSFRDWISFQHEFVTSRMAELVKQVHAAGREAMMFLGDNWIGTEPYGPHFAHTGIDAVVGSVGSGATCRMISDIPGIRYTEGRLLPYFFPDVFHPGGDPVTEANASWLAARRAIVRSPLDRIGYGGYLSLAVQHPEFVDRMEEIVNEFRAIHAAAAGQRPITTGPRVAIVNCWGGRCAAGRPTWSPMPCTTDRPTRTSASLSRSVGCRYRWTFSASTTSTTACPRVLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPV0</accession>
    <name>W4TPV0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70259">
        <property type="protein sequence ID" value="GAE70259"/>
        <property type="gene ID" value="JCM18909_3562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="57"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="286" mass="30464" checksum="6D6318B1F6ED72D1" modified="2014-03-19" version="1">MLWSHDVTAAVPTPHPSWIDGSQPRLAAADVPICRGFSRRNSQHLAPHPLWIFRCGSFGLIVAEATAVSPEGRISPCDTGLWNDAQVAAWRTITDAVHELGGTIAVQLGHAGRKASTEKWWPGFHGGVVPPEKGGWIPVGPTAVPADGKQYAGSPVTALNEDGISKIIDDFRAAASRAVVAGFDAVEIHSAHGYLLHQFYSPLSNTRTDGWGGDYDGRVRLPLAVADAVRGAIPDDMPLLARLSVTDWRDDGWSVEDSIELSRRFALAGVDLVDASSGGNSSAPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQF9</accession>
    <name>W4TQF9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70643">
        <property type="protein sequence ID" value="GAE70643"/>
        <property type="gene ID" value="JCM18909_4005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6670" checksum="961DD399B38115AE" modified="2014-03-19" version="1">MSAVFAWPARVRRGDEDVEPVRWATIGFDGAGRVIEVVFVRGADGSVLVIHANWLTKGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQI7</accession>
    <name>W4TQI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar ABC transporter sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000064">
        <property type="protein sequence ID" value="GAE70673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70673">
        <property type="protein sequence ID" value="GAE70673"/>
        <property type="gene ID" value="JCM18909_4049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022387">
        <property type="entry name" value="Bind_CPR0540"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03850">
        <property type="entry name" value="bind_CPR_0540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850876" evidence="1">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="283" mass="30099" checksum="C2A4747015222220" modified="2014-03-19" version="1">MVGLAASAATVPLAACSPGSRTMASTSGGAGKASGVIKVAAFENAYGAAIYKQVAEAFEKATGAKVELTVSKTIDQELTPQVAAGNFPDVVFMGVGGKTGFTDKFVQNKSLEPLNDILKITNKGEITTVGDKLLPGMVGNLTTNPYDDDRLMLAPTFMAPAGLVYNKTLFAKNGWTLPATWDEFFALGDEVKAKGISLFTYPTAGYFGTFFFVLLSSIGGDDYFKKVMSYEKNIWTGSEATQALNLVGKLLTQYTLPQTVGYANNQDYTKNQAALMADKALFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQL6</accession>
    <name>W4TQL6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mur ligase middle domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000071">
        <property type="protein sequence ID" value="GAE70703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70703">
        <property type="protein sequence ID" value="GAE70703"/>
        <property type="gene ID" value="JCM18909_4083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurT_C" evidence="1">
        <location>
            <begin position="196"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="263" mass="28674" checksum="323573805B802147" modified="2014-03-19" version="1">MLETDERVVADVVAMGSPEVLVLLNFSRDQLDRNHELAFLGRDWRAALEKAAEHGPTVVANACDPLIVWVCQKARHVIWVDTKPRWTADATLCPNCGAVLIHSDQGWDCPGCELQQPAADWWVEDHDAVEASGRRFHLDVQVPGSFNLTNATCALAAAIHMGIQPEDALRGIATVKSPAGRYATCTISGTRCRLLLSKNPAGWTESLPLTTSNPLVLTIDAVAADGKDVSWLWDVDYEQLAGRTVICAGPRALTWPSDCNTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQM8</accession>
    <name>W4TQM8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-dependent lipid II-amino acid ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70534">
        <property type="protein sequence ID" value="GAE70534"/>
        <property type="gene ID" value="JCM18909_3872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="2">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17562" checksum="339A4495059DD5FE" modified="2014-03-19" version="1">MKLGTRDDLARFHKVYLETAERDGFTGRPLEYFEHMWDVLNAEEEGRMKVFLAEHEGDVVAATTFVTVGEHAWYSYGASTTVKREVRGSNAIQWAMIRTANEAGCAVYDMRGIVAGVGADDPEIGSSSLRLVAVARQWPSRVSGISPSTRSCTRLLTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR12</accession>
    <name>W4TR12_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000065">
        <property type="protein sequence ID" value="GAE70684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70684">
        <property type="protein sequence ID" value="GAE70684"/>
        <property type="gene ID" value="JCM18909_4060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="6275" checksum="8D9C9B279FE0E4C4" modified="2014-03-19" version="1">MTGTVLRDRAVLGMKVVDESRFGRVLAVRLCRWVLWRWPRVEFQSSVVSSRLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDF8</accession>
    <name>W4TDF8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_9</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66980">
        <property type="protein sequence ID" value="GAE66980"/>
        <property type="gene ID" value="JCM18909_9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="11"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="446"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE66980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="580" mass="64208" checksum="87ACD813072C29C3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE41</accession>
    <name>W4TE41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endo-beta-N-acetylglucosaminidase H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_75</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67041">
        <property type="protein sequence ID" value="GAE67041"/>
        <property type="gene ID" value="JCM18909_75"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8062" checksum="4EE75F0B0B54D635" modified="2014-03-19" version="1">MVRHLSGTIDAGYASKSYGGAAAVDWGHTSIDMIQTMACQTIRDGYGVFMTYDLRVSTNPSLVRAMTTALEGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE99</accession>
    <name>W4TE99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67111">
        <property type="protein sequence ID" value="GAE67111"/>
        <property type="gene ID" value="JCM18909_150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11281" checksum="C51207EE59C6FEC5" modified="2014-03-19" version="1">MAATTKSFTRRGPYAKGVARRAEILDVALRLYGASSGERPTLTAIAAEVGLTEQAFCTTSGRWTNYSWRFLRLVTSTRSMLVVSLTLTMCGHTWPRRPALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEK2</accession>
    <name>W4TEK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arginine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67395">
        <property type="protein sequence ID" value="GAE67395"/>
        <property type="gene ID" value="JCM18909_452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12107" checksum="4E51E34EC89BE9D0" modified="2014-03-19" version="1">MRWPARQQETVLASAIYTHHPIFAERDFKIWYGCAEADHGMSTLEGGDIMPVGNGTVLIGMGERSSWQAITQVARSLFAQNAARRIVVAAMAPDRAPCISTRCLVSVTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEQ9</accession>
    <name>W4TEQ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67281">
        <property type="protein sequence ID" value="GAE67281"/>
        <property type="gene ID" value="JCM18909_327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6580" checksum="0502E9B14DE6A95F" modified="2014-03-19" version="1">MQNSGTFGSQAFGLSGLLMAPVISAGKWGWYLGGWLISVIMGAVLTYLFGFKDSMAERIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TER2</accession>
    <name>W4TER2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteroides aerotolerance operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_47</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67017">
        <property type="protein sequence ID" value="GAE67017"/>
        <property type="gene ID" value="JCM18909_47"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="BatA" evidence="2">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="96"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="291" mass="31870" checksum="EAF6262021D79666" modified="2014-03-19" version="1">MTPLFLGLPEVKSSWVLWLLLLVPVLLVFYIWASHRSRTTAMRFTNTAILGAVMSKQPQWKRHIAVAAALLCVAATTVAWARPMGIEQVPRNRATIVVAIDSSLSMKADDVSPTRLAAAKAKAKDFINSLPTGFNVAVVSISEHPEIRMPPSTDRPTVLRAVDGIELQDGTALGGAIDKSLEAVKMAPGGSKKIRLRPPLSCSVTGIIPKVVLPWWRPTELPRPKSRCTPSPLVPRPGMSTLTGSERELHPIPNSYLLSPTVLTLNRGPPTRRTSSRRFISRCTPRWVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEU0</accession>
    <name>W4TEU0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-succinyl-L,L-diaminopimelate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67470">
        <property type="protein sequence ID" value="GAE67470"/>
        <property type="gene ID" value="JCM18909_532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10367" checksum="1B08384788114D33" modified="2014-03-19" version="1">MSMHEAPIADAVEETLAPHRHLEVTRLGNSVVARTHLGRSERVVIAGHLDTVPVVENLPSYIEQRSDGDYLVGRGTCDMKGGIAVALALAVSLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEV2</accession>
    <name>W4TEV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67321">
        <property type="protein sequence ID" value="GAE67321"/>
        <property type="gene ID" value="JCM18909_368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_His" evidence="1">
        <location>
            <begin position="9"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="388" mass="43054" checksum="F6484A9A7B0025B3" modified="2014-03-19" version="1">MARLKPLSGFPEFLPSGQMVENHVTRILEETFELHGFAPIRTRAVEPMEQLTRKGEIDKEVYVVDRLHADSHDTRSGKDRLGLHFDLTVPFARYVLENAGHLYFPFRRYQIQKVWRGERPQEGRYREFTQADIDIVGDQTLAEHHDVETPLVMLSALERLHTELGFPTVTMHVNNRKLSEGFYRGLGIADPMAVLQRVDKYDKIGPDAVRKLLVDELNLSDDAAAKCVALASIQSADDSFIAKVRELGVANEMLEEGLDSLNRVVAAVNKAVPGRMVANLKIARGLDYYTGTVYETELTGHESMGSVCSGGRYESLASDGKHAYRGGHFSRPDPLADADPVPWRAVVLALGALGGSGCRQCGRGSCYVGGCRCRPAFPRHPMRSSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFD1</accession>
    <name>W4TFD1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67675">
        <property type="protein sequence ID" value="GAE67675"/>
        <property type="gene ID" value="JCM18909_752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045931">
        <property type="entry name" value="DUF6350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19877">
        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18595" checksum="DF9E00CAC7424821" modified="2014-03-19" version="1">MVTEKKLLVDGRVPYNFLPQTEQDPRMVRSGSTSTSARFVIESSKADESRESRVPWPWPVVVVVAAAAAILVQWLAFAGIIVPEWLASNGRSFPSILAAASSLWLSGHGVPVDIIGVHIGLIPFGLTCVSLLLGEEACRYGTRVLWHRHDKRPARRHVGEAVAFTPQLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFE0</accession>
    <name>W4TFE0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IMP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67685">
        <property type="protein sequence ID" value="GAE67685"/>
        <property type="gene ID" value="JCM18909_763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="35621" checksum="C702EB1D3A6D28C1" modified="2014-03-19" version="1">MCNLYPFSETVAQGGDFNECIEKIDIGGPSMVRAAAKNHANVAVLTNPDQYKDLARALSEGGYTMEERRVLAARAFAHTAAYDVAVATWFGSRDGVAVDGVPTFVGTTGELSCPLRYGENSHQAAAVYRSSGEPGLAGARQLHGRAMSYNNYVDTNSARRAAFDFEAPCVAVIKHSNPCGIATGSDIAEAHRKAHACDSLSAFGGVIATNRPVSVEMAEQVAEIFTEVVVAPGYEDGAVEILSRKKNIRLLECPAPNLAGWELRQIDGGLLAMETDLFQADGDDPANWTLAAGDPVDDATLADLSFAWRACRSVKSNAILLAHDAPQWVSAWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFF3</accession>
    <name>W4TFF3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tryptophan synthase</fullName>
            <ecNumber evidence="3">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67257">
        <property type="protein sequence ID" value="GAE67257"/>
        <property type="gene ID" value="JCM18909_302"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="4139" checksum="F808BD7E9CD8ADE7" modified="2014-03-19" version="1">MKALTTGTTGTGVDLVVIGMPYSDPMMDGTVIQHVTTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFG0</accession>
    <name>W4TFG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67501">
        <property type="protein sequence ID" value="GAE67501"/>
        <property type="gene ID" value="JCM18909_564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007423">
        <property type="entry name" value="Sel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04328">
        <property type="entry name" value="Sel_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="9411" checksum="05D9AE40F6A519DF" modified="2014-03-19" version="1">MWRRCWSSLRWWVRGVTGADAYDKYLEWCRRTRHEPMAEKAFWRDQCDRQDRNPQARCCWPPLTDTLPIGPITGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFI6</accession>
    <name>W4TFI6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphotransferase system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67531">
        <property type="protein sequence ID" value="GAE67531"/>
        <property type="gene ID" value="JCM18909_596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9060" checksum="EFB53BF7210FBF34" modified="2014-03-19" version="1">MKRVEHILAALGGVDNVVSIEPCVTRLRCQVRRCEQIDEQALRRAGAHGVTVQGHSVQVIVGPDADLLASDLEDLWEEDRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFL1</accession>
    <name>W4TFL1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67561">
        <property type="protein sequence ID" value="GAE67561"/>
        <property type="gene ID" value="JCM18909_629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="35"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="431" mass="45979" checksum="23CABE07AC9389C9" modified="2014-03-19" version="1">MAANIPLTNTASLTPDTQLASAPISPESRRFLRHVTAATAFGGGLDGFDLGVISVVILHINHDLELTPAMEGLVGAASLLGIFIGAPLFGFLTDKFGRRRMFLVDIIAFIVIGVGQAFAMGGVSLGILRFLLGMAIGAEYSIGAPMLSEFVPARERGSKLAFLELCWRIGFLIAVLLGYALLWSGVSWKVILATSVIPASLCLGCESVFRNPRAGCCATAARPKHVRSSKKHMGPKYFAAEQLSEESVDGEGYRKLFRKGQRRRTIFVCVFWTCIVTPYFAIFTYAPKVLESLNVKSQAGGTILSNTIGVVGAVVGLLAIDRIGRRRMLIGPFWVQTAVLLIVGLWTDAPSWVLMVGLALFALVNSYSDILTAVYPSEIFDTDIRSSGVGFGSQSAALVPSLAPTCCPLASGQSGSSGAWSSRQVYASLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY7</accession>
    <name>W4TFY7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67422">
        <property type="protein sequence ID" value="GAE67422"/>
        <property type="gene ID" value="JCM18909_481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="15"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="30473" checksum="587F4AA76D05DBF9" modified="2014-03-19" version="1">MSTSAEAFASAEPMVHITGLHKEFGPLHILKGIDLDVAPGEVCVLLGPSGSGKSTLLRRINQLETFETGEIWVGGQRVGYEHDPLPDGRLKRLSDKGIAAQRARVGMVFQRFNLFPHMTALGNVMEAPIKVSGLTKEEAKPLAMSLLNRVGMADRADHYPAELSGGQQQRVAIARAMAMKPELMLFDEPTSALDPELVGEVLSVLKDLAGEGMTMIVVTHEMGFAREVADHVVFMDNGVVVEAGSASQVIGNPKSDRYAGLSILCCEMSCRHDTVTVCMMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI5</accession>
    <name>W4TGI5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67264">
        <property type="protein sequence ID" value="GAE67264"/>
        <property type="gene ID" value="JCM18909_310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="GXGXG" evidence="2">
        <location>
            <begin position="469"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="553" mass="60084" checksum="642EF7025950BFD3" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK9</accession>
    <name>W4TGK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67289">
        <property type="protein sequence ID" value="GAE67289"/>
        <property type="gene ID" value="JCM18909_335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="47" mass="5231" checksum="51D008C5287E84DB" modified="2014-03-19" version="1">MRAVVVPALFNISEPIMFGLPVMMNPFFYYTLPPRAVGAMRGNLVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR9</accession>
    <name>W4TGR9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6 7">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplS</name>
        <name evidence="8" type="ORF">JCM18909_1284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6 7">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68165">
        <property type="protein sequence ID" value="GAE68165"/>
        <property type="gene ID" value="JCM18909_1284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13109" checksum="EC149339F8903C53" modified="2014-03-19" version="1">MSNIIDEIDKTSMRDDIPEFRPGDSVKVHVKVVEGSRTRVQVFSGIVISRTGGGVQESFTVRKLSFGTGVERTFPLHSPIIDKIEVDRHGAVRRAKLYYLRGRRGKAAKIKERGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU0</accession>
    <name>W4TGU0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:alanine symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67643">
        <property type="protein sequence ID" value="GAE67643"/>
        <property type="gene ID" value="JCM18909_716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25688" checksum="785F8FE684F4DE8B" modified="2014-03-19" version="1">MWEPFIDSVVICTMTAITIIITGVYRNGGANGVQMTAQALKTVAPWFSSLLTLAVVLFAFSTMLSYSFYGKKAVGYLFGNSTTAERIYNALFLILLVVGAATNMASILGLADAMLFLMALPNVLGMYFLARVVAREIKGHRERIDAGVIPQVPEDARVGMMVVNEATPEQLENADTEYALRAAAQDARSKELKLGHTAPDTERDYLQHLPEGHEIFNTMDREGKPLKNRRHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX8</accession>
    <name>W4TGX8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="4" type="ORF">JCM18909_761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67683">
        <property type="protein sequence ID" value="GAE67683"/>
        <property type="gene ID" value="JCM18909_761"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="207" mass="22254" checksum="B12F2CED7204B7FA" modified="2014-03-19" version="1">MAFRVVVLVSGTGTLLQSLIDDLPEQVSIVAVGSDQPDAVALQRAQTVGIPTFAEPLPRSDAQTTMRAAWDARLTDAVARFDPDLVVCAGFMKLLGQTFLDRFGGRTINSHPALLPSFPGIHGPRDALEYGVKITGATVFMVDAGVDTGRILAQRAVPVLTDDTVESLHERIKVEEREMLVTVVTELAGVRPGMEELGTESSRKDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH03</accession>
    <name>W4TH03_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c-type biogenesis protein CcsA/ResC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68056">
        <property type="protein sequence ID" value="GAE68056"/>
        <property type="gene ID" value="JCM18909_1165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6001" checksum="A5AEB998AF7BCE6F" modified="2014-03-19" version="1">MVTWVVYAAYLHARSTAGWRGRPAALIAIVGAACFWFNFVGVNLIFNGLHSYAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH41</accession>
    <name>W4TH41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67748">
        <property type="protein sequence ID" value="GAE67748"/>
        <property type="gene ID" value="JCM18909_829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="PTHR32015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="240" mass="25894" checksum="16EE26F06F274E75" modified="2014-03-19" version="1">MRSPHGPSTDHLAHEGYCVYTFTTNVPVGILDEGWGFTGDVRASAQALGAFVDRVRKATGSEKVDFVGHSQGGGILPNAYIKMYGGASKVDKLIGLVAANHGTTAVGLDKLVDGLPEAVKDFLSTWSYDHNMEAYGQQLKGSALMQQVYRDGDTVPGIAYTVISTRLDMTVTPYTQAFLKGAKNMTVQDACPLDAYGHGRLPYDPVAYQMVLNALDPNHPREISCTWRPRVLPVSTTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH54</accession>
    <name>W4TH54_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA small subunit methyltransferase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68116">
        <property type="protein sequence ID" value="GAE68116"/>
        <property type="gene ID" value="JCM18909_1233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22066" checksum="86BA26882BA7172E" modified="2014-03-19" version="1">MSRIIAGRAGGQRLTTPPGRLTRPTTDRVREAVFSALAAWNGTANEVPEDQLAGQAFCDLFAGSGAVALEAASRGATTVVAVDRDRCACNVMKDNSRTTRLRIEVSSQAVTAFLAENHRVFDVVWFDPPYDLAADDMDSLILTACDGALAHNGLLVVERSRRSRDPRFPDGYESWNSHYGETVVYYAQRTGEPEVDAGREQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA9</accession>
    <name>W4THA9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67818">
        <property type="protein sequence ID" value="GAE67818"/>
        <property type="gene ID" value="JCM18909_904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="21500" checksum="33BBDA22D8A8B424" modified="2014-03-19" version="1">MRLDMRNPQARAHLDTVIDRMVSYGIGYLKIDDNFSVGSGPDEDADSPGDGLLEHCRAWAAWLADLPRRHPGLVVENCASGGHDHRLRLLARTAIQSTSDLQDSVRYPPIAANSPMTMLPEQAANWAYPARHGRRGNRLYRHDLLGRHLLPVRSCRPHERPPDGSRAIRRRGSQGLTIRSDQPHTVVAERPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC6</accession>
    <name>W4THC6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67838">
        <property type="protein sequence ID" value="GAE67838"/>
        <property type="gene ID" value="JCM18909_925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="4548" checksum="7A2845D7A8366E03" modified="2014-03-19" version="1">MNLDMGDVHLAVVCGFPSGKHTSAVKAAELAKPSPQGPRRSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG4</accession>
    <name>W4THG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ClpB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67878">
        <property type="protein sequence ID" value="GAE67878"/>
        <property type="gene ID" value="JCM18909_970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="116"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="6">
        <location>
            <begin position="283"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="375" mass="41494" checksum="409B06DD2D645320" modified="2014-03-19" version="1">MRTAADKYQREGDFGRASEILYGQIPGLEKEMEAAAKAEEETPRMVSEEVGTSDIAEVVSSWTGIPVGRMMQGEQEKLLHMEERLHERLIGQDRAVKTVSDAVRRSRAGISDPNRPTGSFLFLGPTGVGKTELAKSLAEFLFDDETAMVRIDMSEYMEKHSVSRLVGAPPGYIGYEEGGQLTEAVRRRPYSVILLDEVEKAHSDVFNILLQVLDDGRLTDGQGRTVDFRNTIVVLTSNLGSQFLSDASLDDHAKREAVMGAVRQAFRPEFLNRLDDVVMFDPLSMADLGRIVETNLAKLNSRLAERRITIAVTDAGKDWLAMAGFDPIYGARPLRRLMQTTIDDQLARKVLSGQVQEGDTATFNINEAGDGLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH3</accession>
    <name>W4THH3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67609">
        <property type="protein sequence ID" value="GAE67609"/>
        <property type="gene ID" value="JCM18909_682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7132" checksum="86B13E0AB222C021" modified="2014-03-19" version="1">MTDFRSRVVDLVGDDYKRHAMGIAARASIENRTWENLCAELVEHYKEAIRLAGRSTRIRAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI1</accession>
    <name>W4THI1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68251">
        <property type="protein sequence ID" value="GAE68251"/>
        <property type="gene ID" value="JCM18909_1374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8383" checksum="11AEF1C70335AC78" modified="2014-03-19" version="1">MAGALADRMSKRRIMVTAQIVMAIDAAILSTLVLTGIVQLWMVFVISAMDGLAGAFYSPATQAFVPELVPLKKTSPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP0</accession>
    <name>W4THP0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67694">
        <property type="protein sequence ID" value="GAE67694"/>
        <property type="gene ID" value="JCM18909_772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8916" checksum="5030C560241F9DEA" modified="2014-03-19" version="1">MAPVPPDDDARAEFEGFNLAEFSRRVDQTRAALLSGLETARSSIRVPAARWCFGTRPPMSWQTGYVTSAWLGHCTGIGRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS0</accession>
    <name>W4THS0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transport ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68336">
        <property type="protein sequence ID" value="GAE68336"/>
        <property type="gene ID" value="JCM18909_1465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20174" checksum="4550F98453763912" modified="2014-03-19" version="1">MRTLRISFLSSFVLELLATLSVALVAVTVGFRVAAGGMDLRTSLFILILAPEVFLPVRQVGVLFHDAADGMAAAEVSFGLIESGRPTAPKSDVEIASPREVPVVISGLTHTYEGTDRAAPDGLSLRIEPGSVVALVGHSGGGKTTALSCLLGFIDPDSGSILVGDRELIGADESVWQSWRRQLATCLRCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU5</accession>
    <name>W4THU5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUFU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68510">
        <property type="protein sequence ID" value="GAE68510"/>
        <property type="gene ID" value="JCM18909_1653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUFU" evidence="2">
        <location>
            <begin position="70"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="230" mass="24566" checksum="ECE219F43ABFCDD5" modified="2014-03-19" version="1">MSDENVSPAARLPDGDELTAERPLDPQDLPEHLAEPTQMPSTGPQVAQAVVEAVGGTPRADGMVDAAEEVRIDVLAFADAPAPGWSTWSTVSLHAEPNAVALVDGTSSDIRAELMVVGAPGSDVMGKVLGSCAFAVLRDHWSMGPGIVFGDVVSMYAPNSATPHLMWCHPFTTPQLDQVDIGDMKVHWLLGVPITEAERQWLEANGFDDFVELLDAKAVNYTDLQRPSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI07</accession>
    <name>W4TI07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68063">
        <property type="protein sequence ID" value="GAE68063"/>
        <property type="gene ID" value="JCM18909_1175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="17922" checksum="A387487692606472" modified="2014-03-19" version="1">MRILLRQASWWGLGLVSVWIIVTIGLLQRYPQARKSFALTTGNFSVVTVILSPLCCAVGIAYGARLRRSGVVRTSQGWPRSAASTIIATWVAVTGAVLLVSAAVTTGILALLAAGRCDPRLMVGPLLTALAATAFLTFGAFLGVVTVLSLCCGRCDRHLCPDSDHPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI28</accession>
    <name>W4TI28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68610">
        <property type="protein sequence ID" value="GAE68610"/>
        <property type="gene ID" value="JCM18909_1757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12090" checksum="6B4E63C20F8F055C" modified="2014-03-19" version="1">MIGDETTARDIARAGWVAGTAGVVRVGLTGGIASGKSTVSQMLGERGAVIIDYDRLSRDVVAVGTQGLARVVEPLGVRFLLLMVLLIDRLWGRSCLLICRRVAVLKPLFIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI46</accession>
    <name>W4TI46_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68426">
        <property type="protein sequence ID" value="GAE68426"/>
        <property type="gene ID" value="JCM18909_1563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="9678" checksum="700FC10A7856B353" modified="2014-03-19" version="1">MDTPIGADVGLEAEDVRTSTGGRLTDTVVDELVEAATEARGAGRPSLSSPGVRSPSVTVRLPQGLNAKLDHEAARTGKRRSEIVREALEAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE9</accession>
    <name>W4TIE9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68740">
        <property type="protein sequence ID" value="GAE68740"/>
        <property type="gene ID" value="JCM18909_1895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="2">
        <location>
            <begin position="199"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="284" mass="30557" checksum="2DD7C14F9E6FACB7" modified="2014-03-19" version="1">MDQRRPLPRFQTSARLTSPQAAPVKEIVADPETSPSSASTSRFQTRCDHDKGDVVIWVDSFSDMLEGSDLSAVVTVLADAGYHPRVLTDDVCCGLTWITTGQPDGARRRVRAGLDVLTPLSDANVPVVGLEPSCTTVWRDDALRLLSDDPRVRRVARNMHTVAEMLEAANWTPPSLAGHTIVAQPHCHHASILGFGPDKRLLEAAGATVTVVSGCCGYAGNFGVEKGHYDFSVKVAHNDLLPAIEEAGPQAIILADGFSCRRQVSDLIGRRALTLAEVFASHVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG0</accession>
    <name>W4TIG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68223">
        <property type="protein sequence ID" value="GAE68223"/>
        <property type="gene ID" value="JCM18909_1345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7784" checksum="F73B0D86DB06DDBA" modified="2014-03-19" version="1">MSMKMFDLIYAIAGQSSYTAEVPATLMWTQMFQLNNPTAAAVNATILLVIVAVVVVPYLVYTNRTERQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ2</accession>
    <name>W4TIJ2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
            <shortName evidence="6">DHNA-octaprenyltransferase</shortName>
            <ecNumber evidence="6">2.5.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">menA</name>
        <name evidence="7" type="ORF">JCM18909_1377</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26478"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:11173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="EC" id="2.5.1.74"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MenA family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.74" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68253">
        <property type="protein sequence ID" value="GAE68253"/>
        <property type="gene ID" value="JCM18909_1377"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046428">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01937">
        <property type="entry name" value="MenA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004657">
        <property type="entry name" value="MenA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005355">
        <property type="entry name" value="UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="292" mass="29944" checksum="DA5465F1067D32F8" modified="2014-03-19" version="1">MAAAAEWLEGARPRTLPTAIAPVLAGTAIAITDGGARWGLAALCLVVALGLVIGVNFANDYSDGVRGSDGDDRVGPLRLVGSGLAEPSHVRTAAFACFVVSAVAGLVITIMTGHWWFIAVGVVCILAAWFYTGGSHPYGYAGLGEIFVFIFFGLVAVGGTIYVQSGHVGAAGWVTACLIGATACGVLTANNLRDIDGDRVSGKHTLSTKLGHQGTRIFYLVLVTLACVGVVVVAALTTWWVLLGLFAIVLFVSPIRAMVTKATGMALVPALKSTGLAELVCSIGLFVGALVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK4</accession>
    <name>W4TIK4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68263">
        <property type="protein sequence ID" value="GAE68263"/>
        <property type="gene ID" value="JCM18909_1387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849100" evidence="1">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="15253" checksum="B1329033BA6D8663" modified="2014-03-19" version="1">MFVQIAASLAAASSIALGIPGAATPIDESQLPVGPQVSVTDSAQHTGPFAASSPLAITVKPGAPCVRADGYQESMVTRVLDDKGHQVWTGTFDESKLIGGTGLGTATFHVESPAAAFNFHGNERTTYRTLSYCATRTTSTAPGSVCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN0</accession>
    <name>W4TIN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68820">
        <property type="protein sequence ID" value="GAE68820"/>
        <property type="gene ID" value="JCM18909_1984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9394" checksum="06202843B0E8B0DB" modified="2014-03-19" version="1">MNGAYDMCAEHAEALSAPVGWEVIRLPGIDNPAPDPPADDLMALAAAVREVGMLEDEVLLEPDPASVHVLGRRGHLSVITDASRDVTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN9</accession>
    <name>W4TIN9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67999">
        <property type="protein sequence ID" value="GAE67999"/>
        <property type="gene ID" value="JCM18909_1104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="268" mass="28323" checksum="EB54F4FDF4DB1A44" modified="2014-03-19" version="1">MFKTLQKIGKAFMLPIAILPAAGLLLGIGGALSNPTTVKSYPVLDNPILQDIFQVMSAAGNVIFENLALLLSIGLCIGLAKRDKGTAALAGITGFLVMTATTKALVVLSRHPDRTIDTGVVGSLVIGAIAVWLHNRYHNIELPAFLGFFGGSRFVPIVTAFAGIIIGAFFFVVWPPIQAGMVSAGTAIADWGVIGTFFYGFLMRLAGAVGLHHMIYPMFWYTPLGGTEAVAGKTVVAHRRFSSPSWLIPTMSDCSPIPPSTLPVASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP5</accession>
    <name>W4TIP5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68656">
        <property type="protein sequence ID" value="GAE68656"/>
        <property type="gene ID" value="JCM18909_1807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="23976" checksum="F9F309F14DB49096" modified="2014-03-19" version="1">MSADPDSLQLRVTVKGEVLTLDASILATTRQRILKRNRYNDGREAVEVSLRDQLWARVPADVLATHDLTRDDFDELVSSQASWRMLLNAWWPALSASDVLARLADPAVAEAVTPDWNEETRQLLVSSIPTEADRRGWRNWSIADMALLDELAALLGPVPPEPDADDPVFIEGGDAEELDTLGDRLHESRHIDEDELAIPSLTFSSTRPKTSPPCSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ7</accession>
    <name>W4TIQ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68671">
        <property type="protein sequence ID" value="GAE68671"/>
        <property type="gene ID" value="JCM18909_1822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="342" mass="36778" checksum="01AF2E13F0658B35" modified="2014-03-19" version="1">MMRYLKRLADRDYGLDRGMIPLGSCTMKLNAAAEMEAMTWPAFSQMHPFAPVEDQAGSLRLIRDLEIWLAELTGYDTVSLQPNAGSQGEYTGLAAIRGYHVSRGDTERNVCLVPASAHGTNAASAASAGLRVVVVKSHDDGTIDRDDLAAKIAANEERIAAIMITYPSTHGVYEDGVRQVCDMVHEAGGQVYIDGANFNALVGWGQFARIGGDVSHLNLHKTFAIPHGGGGPGVGPVAAKAHLAPFLPGHPLNPRNEHPLNDGGTVTHDGHAVSAAPFGSVSVLPISWAYLRLMSSKDCNSRLRWRFSMPTTSPTGSTTRSRSSTPDRMATWLTNAFLIYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR9</accession>
    <name>W4TIR9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68407">
        <property type="protein sequence ID" value="GAE68407"/>
        <property type="gene ID" value="JCM18909_1542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="19568" checksum="70DF117B108ED15B" modified="2014-03-19" version="1">MHMSAKGFTIAVAGASGYAGAEVVRLLSGHPALTMGDLAAHSQAGLPLAHVMPHLVGVAKERTLSEIDVERLASHDAVVLALPHGASGQIVQELVKMNPGLVIVDAGADFRLSSASDWQRWYGSDHAGTWTYGLPELPRAEGGSQRDMLSAATRIAAQGAMPPRLPWDWRPSSALLTLLSRQPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS6</accession>
    <name>W4TIS6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68049">
        <property type="protein sequence ID" value="GAE68049"/>
        <property type="gene ID" value="JCM18909_1157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20172" checksum="2600739A36BF5A4E" modified="2014-03-19" version="1">MAARAAEHFAGAELSALVSSPLERARETMAPIAALHPGLEVRIDSDVIEAANVFEGQVFGKGNKALRSPRNWRYLSNPLTPSWGEPYVEIAERMTRAIMRAAEEVPVGGQALIVSHQLPIWIARCAAEGRRLPHDPRFRKCTLASVTSFGVLHGRIVRVDYCEPARDLIPAKDRRANISAGGAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU7</accession>
    <name>W4TIU7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68348">
        <property type="protein sequence ID" value="GAE68348"/>
        <property type="gene ID" value="JCM18909_1477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7942" checksum="94180CD12D5AC900" modified="2014-03-19" version="1">MATDSRLRAALEANHGDAAMLIVAQRVSTIRNADQILVLDAGHIVGRGTHDELIKSCPTYLEIVDSQLSVEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV3</accession>
    <name>W4TIV3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68885">
        <property type="protein sequence ID" value="GAE68885"/>
        <property type="gene ID" value="JCM18909_2056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9650" checksum="A53CFB8C27E112EF" modified="2014-03-19" version="1">MTVVVGRNGARRCAPSASKSQILKGGREVARATRALAGRVSVREIPSVALEHVADDVEVLAQARRAQAVAEAFPTPSLPPPGNQGWLVWCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY9</accession>
    <name>W4TIY9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68756">
        <property type="protein sequence ID" value="GAE68756"/>
        <property type="gene ID" value="JCM18909_1913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="210" mass="22741" checksum="25589598DEBC916A" modified="2014-03-19" version="1">MVHNGIEYADMQFIGEAHSLVRAAGLTNAEAADAFESWNHGDLNSYLVEITSRVLRAKDPRNPDTDLLDVIRDEAEMKGTGTWTVQTALELGVDVSTISEAVFARSVSSAVPLRTVGQHVLAGPEHTIAVEDRQAFLTDVRDALWSAKVVAYAQGLDEIRTAAAEYNWEVDMGQIASIWRDGASFARVCSNASGMNTPPVTSSPSLKPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ83</accession>
    <name>W4TJ83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68219">
        <property type="protein sequence ID" value="GAE68219"/>
        <property type="gene ID" value="JCM18909_1341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="19964" checksum="0148C5A5B27504CE" modified="2014-03-19" version="1">MSRHPGRVDGVILNSPWIDLQGSFLTRALAGPLARSVRVAEPTTVLPIPSRDNFGHSIRREFGGEWDVPEVKDPSWAPFVTRAGWLAAILDGHQKVAQGLHIDVPLLVLISARSDLSATWKPSMKTADTVLDADRLARAAVNLGRHLTLVRVRGGLHDVVLSAPSVRAGVFAEMERWVNAYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB7</accession>
    <name>W4TJB7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galacto-N-biose-/lacto-N-biose I ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68503">
        <property type="protein sequence ID" value="GAE68503"/>
        <property type="gene ID" value="JCM18909_1646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16618" checksum="DB38C6244AE814BC" modified="2014-03-19" version="1">MASRKARHEALTGWLFALPFTIVFIIVFVAPIIESIRAGFHKQVAEEGGLYGGGRTVEKFVGLENFQDVCTNPAFWHGIGRVMLFGVFQIPIMILAALFLALVIDSYLVRHLGFWRLSYFLPYAIPGSWPRLCGPTSTCPRFPLSRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD7</accession>
    <name>W4TJD7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68896">
        <property type="protein sequence ID" value="GAE68896"/>
        <property type="gene ID" value="JCM18909_2068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009937">
        <property type="entry name" value="Phage_holin_3_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07332">
        <property type="entry name" value="Phage_holin_3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="18126" checksum="FACCE2A74D5AD983" modified="2014-03-19" version="1">MADKLPVGDTIDNLKTDGQKFVQDSKALVTAEIKPAAKHAGIGVGMFGGAGYFGIVGALLLWLCGAFAFSLMWQHIGNWDILLSLVVGFATMAVILFILAGVLALVGKGQISQVKAPTGIVDEAKSTLGAVKSAVARGKYNATARSSIDASDAPSPAAPVSVGGASAPRRASGATERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL1</accession>
    <name>W4TJL1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68956">
        <property type="protein sequence ID" value="GAE68956"/>
        <property type="gene ID" value="JCM18909_2133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14430" checksum="C0622FB69A16F18D" modified="2014-03-19" version="1">MSAGTTRVRSVPSLAVHNREKASRGTLTVTTAVVEKVAARVAAQSEGFGAPTSSFFGSGSRADFDRGPKVSAVLTGRTADLEVEVAIGYPAPVQAQCDDLRARLTEQVPKMSGVDIRTIDILVSRVVSKAPTMKELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP0</accession>
    <name>W4TJP0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="2">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68643">
        <property type="protein sequence ID" value="GAE68643"/>
        <property type="gene ID" value="JCM18909_1793"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8449" checksum="BD850A931ED7DACE" modified="2014-03-19" version="1">MSQSVPSLEALNALPRVQQPSYPDPQATAEVVNQLRSFPPLVFAGECDDLRAYLAAVANRKAFFCCKAAIVLRLLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP5</accession>
    <name>W4TJP5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase PknL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68648">
        <property type="protein sequence ID" value="GAE68648"/>
        <property type="gene ID" value="JCM18909_1798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10790" checksum="44C69577000FBAA0" modified="2014-03-19" version="1">MPTQPANHSQPRPRPIHRRATQPASRSRLVQDAVHRRRRGVIAAVFIVLVAVLCAYLVFHFTSSRYSASELHSTNSVARTCVHGESFCMHTISQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT5</accession>
    <name>W4TJT5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69215">
        <property type="protein sequence ID" value="GAE69215"/>
        <property type="gene ID" value="JCM18909_2409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9715" checksum="FD8B5DAFEFD01949" modified="2014-03-19" version="1">MGTMLQSSDVTVEDSRTRRLQGNPQHHWPRRHFRSPRRLAGTMLMGSETGAALTVNPLASTPSITKPIVAAGTVSVTPPVRTSKIAPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW5</accession>
    <name>W4TJW5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal-associated domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69250">
        <property type="protein sequence ID" value="GAE69250"/>
        <property type="gene ID" value="JCM18909_2446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="204" mass="21023" checksum="608E52F8DBF26DEB" modified="2014-03-19" version="1">MHKTYTINGMTCEHCVKAITEEVSALDGVDNVTVSLESGSMTIDSAEEIPFGKVADAVDEAGEYTVAEASSLDTAGHPGGQCGCGGHGHAGRKLKDRVAAAADTSTPRRLLLSMPSTLVKAAVAAADTKPEPLVSVEILTSGPGLGPHDAVRPRPPTLTFPTTHRPPGSLGLPVREPVAPDIPDSGGSSTKETHAYPDSPRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX2</accession>
    <name>W4TJX2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69096">
        <property type="protein sequence ID" value="GAE69096"/>
        <property type="gene ID" value="JCM18909_2283"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850791" evidence="1">
        <location>
            <begin position="29"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="17887" checksum="6DEA3C5D75B87D4D" modified="2014-03-19" version="1">MKRTVLTGAVAACLGMAAFAVTTPDARAESAPVPVPTSRATARSRLANFPSSGITWSPRHHGIVPPEIHGGTIYLPDISADPIILPTIKGGTITLPDIKGGTITLPDISGRPIILPKIEGGVVSIPPIVFPSLHARGSIQVNGTLPGWANGRGNFLAAGGMGAPAGRPMSLPQTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX7</accession>
    <name>W4TJX7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69101">
        <property type="protein sequence ID" value="GAE69101"/>
        <property type="gene ID" value="JCM18909_2288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFG_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9719" checksum="7267498A62C2C81C" modified="2014-03-19" version="1">MAVEVTTPEDYLGTVIGDLNSRRGQIQEMVEEHGNKVVRALVPLSEMFGYVGDLRSKTSGQASYSMEFDSYGECPSSVADEIIAKANGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY6</accession>
    <name>W4TJY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68424">
        <property type="protein sequence ID" value="GAE68424"/>
        <property type="gene ID" value="JCM18909_1561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012550">
        <property type="entry name" value="DUF1706"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40658">
        <property type="entry name" value="PTHR40658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08020">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031551">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="179" mass="20368" checksum="0BF2171951412602" modified="2014-03-19" version="1">MPRPTTKSELLAAASTSFKKLTKLWDKFTPEQAHASFPAALLTGGTEAHWQRDKCLRDVVIHLHEWHNLVTVWVSANQAGTLIGFFPEPYTWRNYAALNEQFVRQHQNTTYEAARDLLAASHQHVLGMIKGFSNDELFTKKHFGWTGTTSLGSYFVSTTSSHYEWAAKKTRAYARILAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ0</accession>
    <name>W4TJZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68852">
        <property type="protein sequence ID" value="GAE68852"/>
        <property type="gene ID" value="JCM18909_2017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17068" checksum="3627D4567A990377" modified="2014-03-19" version="1">MATLRELSPLVEPLSLDEAFVDLEAGDIDVENLDALQQVAVELRARVAERTEGLSCSVGIGSSKFMAKVASEMAKPQRAIPIRSPSSLPVPRLTPSRLCLLRLSLESGRLRRNGWRNWGFALSLTFGLRGSPSWSTSWAMLPGRASSPCHGHGMIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK09</accession>
    <name>W4TK09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68768">
        <property type="protein sequence ID" value="GAE68768"/>
        <property type="gene ID" value="JCM18909_1925"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="448" mass="48275" checksum="2810D4CAE6FA3DE9" modified="2014-03-19" version="1">MNHVTVGPPWTLVSCQESAHESSWMWTHPCGAVLSVQSREGDVAELVAGITMPPGADDTDVTVPGPTWTLDQPVPAIVWAAGASGIVVTRSACDDAALTVWRQDMGDCHPVDEGVSLLGTEVALSPGSARMALWRGHPADAVVEALECLPSWLPCETIVDPPEEMMCRTPDAGILVDGIDQTSETIGPLPMGAHDLVIYESRGATRVMIGWSPHVASAVGARVDEIVSSFDPRTVSGPQTWLLMSAVGMRVAPFDALEMAAEGLENVLSRPFGKGDDHVAKLLTCCAAFRLGHRVGNPELRDEGLRRLWELPMDEPGTFMSRCIASAELAELVPGGVWVNVAVYDGEDSLVRAERAIWAGRFGGRDADEAVWELGAFLPAVPGGPLYVDGHRVPRRRAALAYAMTTVWPEDLTSAFGPMRVGELRQRTARRLLISEHLDDEDLALLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK17</accession>
    <name>W4TK17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69300">
        <property type="protein sequence ID" value="GAE69300"/>
        <property type="gene ID" value="JCM18909_2501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6610" checksum="251DCE99A985661E" modified="2014-03-19" version="1">MALRQSSLIFVVVRGLKAAAWVMELFALEAAFAGGIADSEPIKAVAVTAATVILVRRIVSPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA9</accession>
    <name>W4TKA9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">efp</name>
        <name evidence="11" type="ORF">JCM18909_2430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69236">
        <property type="protein sequence ID" value="GAE69236"/>
        <property type="gene ID" value="JCM18909_2430"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="21120" checksum="02697EA7C6C3D6A5" modified="2014-03-19" version="1">MVISTNDIKNGTVLNLDGQLWTVIWFQHHKPGKGNTVVRTKLKHVLSGKVVDRTFNSDVKIESAEVDRRDMQYLYQDGDTYIFMDESTYEQLPIPAEVVGDAKDFMLENQTATVALHEGNPLYIDLPASVELEITYTEPGLQGDRSTGGTKPATLETGREIQVPLFITTGEKVKVDTRSGDYLGRISEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN2</accession>
    <name>W4TKN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69505">
        <property type="protein sequence ID" value="GAE69505"/>
        <property type="gene ID" value="JCM18909_2727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9656" checksum="8D311D04EB6C30F7" modified="2014-03-19" version="1">MGSEVSDRTVLQDETFCVLRSANIRCVTGLALSTFCTTSRSTSEVSSSSTSKPSAWNITLAFTTRCHYPPDNSSPPMTSTEDGSRPSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT7</accession>
    <name>W4TKT7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">JCM18909_2331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69142">
        <property type="protein sequence ID" value="GAE69142"/>
        <property type="gene ID" value="JCM18909_2331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19809" checksum="19990614F2FCAF7C" modified="2014-03-19" version="1">MSRIGRLPIAVPSGVEVKLDGQYVEVKGPKGTLNFTVREPITVSKNDEGAILVERPDDERENRSLHGLTRTLINNMVIGVTEGYEKKLEIQGVGYRVLSKGPKQLEFNLGFSHPVIVDAPEGITFAVENPTKFSVQGIDKQAVGETAANIRKIRKPEPYKGKGVRYEGENVRRKVGKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV2</accession>
    <name>W4TKV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69157">
        <property type="protein sequence ID" value="GAE69157"/>
        <property type="gene ID" value="JCM18909_2346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7221" checksum="CDFEA487A2155226" modified="2014-03-19" version="1">MWLAGLAGLCVYWCYVNLIYSSAPYLSLVFKASDAVAGAFGIFNTGLLGIISGLVAGYSLTICSSHRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL48</accession>
    <name>W4TL48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69695">
        <property type="protein sequence ID" value="GAE69695"/>
        <property type="gene ID" value="JCM18909_2944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="3">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="58"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13900" checksum="CCC92C0056B3863F" modified="2014-03-19" version="1">MTDREHIQTLLTVARRYWLEQATQAEIAAEIDYSRSMVSRLLDEARRRGIITFTVQHPLERAIELEDALTRTFGLTCARVAMSNDNATADEVARMAADLVTTYMHPDSVIALSNGRGVASVCMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL93</accession>
    <name>W4TL93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69511">
        <property type="protein sequence ID" value="GAE69511"/>
        <property type="gene ID" value="JCM18909_2736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="181" mass="20332" checksum="74B8B21ED61A656C" modified="2014-03-19" version="1">MLGASGGAEKLHYLLEYSHTSRAFRHDLAELLPYGGRNPLYAVIHESSYADGVVTDWSAARMLPDDFREDPTLLTGEHVMPEWFDTDQELRPWKEVANLMANHPWPKLYDPDVLRTAEVPCAAAVYHDDAYVPRKFSLETAALLPQMHAWVTTEYEHNGSNASGGAVLDRLIKLANGEIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB3</accession>
    <name>W4TLB3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III subunits gamma and tau</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68934">
        <property type="protein sequence ID" value="GAE68934"/>
        <property type="gene ID" value="JCM18909_2109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="13250" checksum="8B7CBBF0D9F4F58E" modified="2014-03-19" version="1">MESGPVAGAPDPDSGGAAEPKPDLVPGQDHVEAAGHAESARQIDPGGASSQGRPSAAAVSTAHRWSERAKGSVRPLEVTSRSAQVEEPPDDGGEWDDTVVEESNESPIDLIMRELGGVVIDTDGDSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD6</accession>
    <name>W4TLD6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lead, cadmium, zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69253">
        <property type="protein sequence ID" value="GAE69253"/>
        <property type="gene ID" value="JCM18909_2449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="6650" checksum="9B2782FFB944A1A7" modified="2014-03-19" version="1">MVNISDNPPALAVTAALEVGSEHPISRAIVEACPGVAPAEDFQALPGLGVSGVVNGLPAKAGRVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF9</accession>
    <name>W4TLF9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68989">
        <property type="protein sequence ID" value="GAE68989"/>
        <property type="gene ID" value="JCM18909_2168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070567">
        <property type="term" value="F:cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8270" checksum="B46805B3A64277BA" modified="2014-03-19" version="1">MTDDISCCERYGHHATFVEGSRMSLKITEPVDLDIAEVFAKAAAGAGRHSGRRIGRMLRAVKPSTVARKLGLGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS5</accession>
    <name>W4TLS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69378">
        <property type="protein sequence ID" value="GAE69378"/>
        <property type="gene ID" value="JCM18909_2587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11598" checksum="E5018F960FD20BD1" modified="2014-03-19" version="1">MVPFPVPSGSYRDLAVVKDGVVWIEVADRGGELGATRAGVTGEAPSDVLWHYNLSARHLDKLCERVDTFFSVSGDGERLVVRHRDDIIVVPSSHKVDDDDPPASASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU8</accession>
    <name>W4TLU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNA binding methyltransferase FtsJ like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69935">
        <property type="protein sequence ID" value="GAE69935"/>
        <property type="gene ID" value="JCM18909_3204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12580" checksum="898D362347EE2E43" modified="2014-03-19" version="1">MRDLRPADLAVDGVVEPVDLVVGDVSFISLTMILEPISAVVSPDGLMLLLVKPQFEVGRKALGAHGVVTDPALRLQAIAGVVAAAVELGWRMRDECDSPLPGQDGNVEHFVLLERTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ2</accession>
    <name>W4TLZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-L-isoaspartate methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69214">
        <property type="protein sequence ID" value="GAE69214"/>
        <property type="gene ID" value="JCM18909_2408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="294" mass="31075" checksum="ADC2F5ADCD1A9CB9" modified="2014-03-19" version="1">MWDLDGTLVDTESRWVEAELAILASHGVVWEPERANEFIGGPLTDVCEAMAADLGGSVTVDDVRRELITMVSQFNRERDVPWRPGVLDLLTEVREAGIPMAIVTSSAHAVVEPVLEAMAERIGNPFETVVTFDDVTPETAKPAPDPYLLAAERLGVSITDCLAIEDSPKGATSATSAGAAVLTVTGLAKVGPGPRRVHRRDLSGLSLADVVSLWHLADEPAAPVANGGGGVLRAGERITLTDPKGRKHSIVLQPGGIFHTTKGAVRHDDLIGGPQGVVVTSVGGLDFFWLCARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA5</accession>
    <name>W4TMA5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70115">
        <property type="protein sequence ID" value="GAE70115"/>
        <property type="gene ID" value="JCM18909_3406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="280" mass="30640" checksum="3BB3753491E475A3" modified="2014-03-19" version="1">MASPHFDMGCVEENWGHVWDGSHYRSADVLLHHSVLSLALGSSTLSIYTACTTNSMDSTLQPTTTDLLAEGMEPKASQGYTALPPRLRPGGKDGETLDGLRRLVALRDAISEKGTRWSICYDLDLIIDPGAAFITWRVAGIVKDLLVRYGLHARTIFSSAAEVGLSRPAVRVQTAGDPWESDELCVTVRRGGRDVEWIPMDATQLDAESIWRILQLTPKLPSLDSNSSYRIRWVAGDDSDACLDFIFNRASEKVDVRYGIESSSGGSVVNHCLRLGPTAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH5</accession>
    <name>W4TMH5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69742">
        <property type="protein sequence ID" value="GAE69742"/>
        <property type="gene ID" value="JCM18909_2991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11718" checksum="48DC11F5B73A33F9" modified="2014-03-19" version="1">MALVNVTGFGLMQGLLVVWRGNLLAAMGFHTVWNWLQGMVLGFDVSGLELHHSVMTTARTTGSHSWLTGGTFGAEGSVINTIVLATLITCLLVTMRHDWRDNEAYGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ9</accession>
    <name>W4TMJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70215">
        <property type="protein sequence ID" value="GAE70215"/>
        <property type="gene ID" value="JCM18909_3513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="8057" checksum="9A5BA249A8E5169D" modified="2014-03-19" version="1">MLIGDWSAESGWRLGTLLARMEEVTAIFAASDDMAFGILRAWLTEADVYPRMCRWSAPTMCRWLLLPRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMV9</accession>
    <name>W4TMV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69877">
        <property type="protein sequence ID" value="GAE69877"/>
        <property type="gene ID" value="JCM18909_3142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016833">
        <property type="entry name" value="Put_Na-Bile_cotransptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18640">
        <property type="entry name" value="PTHR18640"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13593">
        <property type="entry name" value="SBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="18140" checksum="F0EC9BF4B5F561C3" modified="2014-03-19" version="1">MIVQLLLPFVLGQLSRRWTADFVTEHRKPLKYVDQGSIILVVYSAFSEGMREHMWSLVSPASMVVLTLICLTLLFFMLWLTWTGSGWLGFNRDDRIAIQFCGTKKIAGDRSAYGDGALRWSTGRPHRATPHDLPPRPAHRLRNAGWPLCAAMGGRAVTDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW1</accession>
    <name>W4TMW1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sirohydrochlorin cobaltochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70315">
        <property type="protein sequence ID" value="GAE70315"/>
        <property type="gene ID" value="JCM18909_3629"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5652" checksum="E69123CE997F7C6A" modified="2014-03-19" version="1">MEAWQASHPGVEIRIAPVIGDCDEVADVVVDRYREPLDEVGLGEGAPFICRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX0</accession>
    <name>W4TMX0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein and sugar binding domain of the LacI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70066">
        <property type="protein sequence ID" value="GAE70066"/>
        <property type="gene ID" value="JCM18909_3351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849154" evidence="1">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="39"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="313" mass="31608" checksum="6C0DFC45ED3D4E56" modified="2014-03-19" version="1">MKFKSTKVLAMAVAATIIATGVAGCNRDGGADSSASGTVVFAVSTQTNPFFVQLVDGAKKEAKAKGVNLQVQDASDDAATQANQLANAVSTSAKVVIVNPTDSDAVAPSVKALNKAKIPVITVDRSSSGGDVASFIASDNIAGGIDAAKKLAEIMGDKGEVIHLQGTPGASASRDRGKGFSEEIAKHPGIKVVAKQTANFDRSKALDVTTNLMQAHSKATGIFAENDEMAIGAISALGSRAGQSVKVVGFDGTADGIKAVKAGTMGATIAQQPALLGKTAVDQAAGILAGKQVSKTTPIKVVLVTKDNAKGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ9</accession>
    <name>W4TMZ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69788">
        <property type="protein sequence ID" value="GAE69788"/>
        <property type="gene ID" value="JCM18909_3040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="140" mass="14812" checksum="CA13B8203640EC79" modified="2014-03-19" version="1">MHAKISDKPLNVAKVVSLVSDDRSGAVVTFTGVVRNHDGGQSVTAIDYSAHPHATQILANLVEQCATRDGVHGVAAEHRIGHVEVGGTAMVVAVSADHRGQAFEAACELVDTVKESLPVWKCQWLTDGSHEWAGLPGEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN47</accession>
    <name>W4TN47_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uronate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3447</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70151">
        <property type="protein sequence ID" value="GAE70151"/>
        <property type="gene ID" value="JCM18909_3447"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="136" mass="15605" checksum="9D49021A807E7789" modified="2014-03-19" version="1">MNVMSTPTLTLFEDRLLLRESSALAVAREIYRSTKGLPIISPHGHVPVSWIADDMAFSDPTSLLITPDHYVNRLLHANGVDLEDLGVGRKTMSEEDNRKAFRILCEHWRDFAGTAMRYWLVDQLVGIFWRHRTTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN67</accession>
    <name>W4TN67_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome bc1 complex Rieske iron-sulfur subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cytochrome bc1 reductase complex subunit QcrA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rieske iron-sulfur protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JCM18909_3473</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70176">
        <property type="protein sequence ID" value="GAE70176"/>
        <property type="gene ID" value="JCM18909_3473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045603">
        <property type="entry name" value="QcrA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19297">
        <property type="entry name" value="QcrA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="17">
        <location>
            <begin position="257"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GAE70176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="369" mass="40391" checksum="417A8F14A9614DCB" modified="2014-03-19" version="1">MSDKYTERNDLPVENPGVEPHVERYTDANPKVGNRAYRQVLTLLGLVPVLAIAFVVVYFAVPRDATVEIGPLYMNASTFGLGLCAGLAVLFIGIACIHWAKQIMGDEEIIQERHPVNSDAADRKEFAKQWRIGAEQSGLSRRKLIGGALGGAIGIMAVPAIVTLADLGPKPGPGTRRATIERTIWAEGVRLVNDVTFQPIKASDLEIGQLVNAEPENLKELEGVEFQRAKAKAAILIVRMDPDSIKIPESRKDWQVGGILSYSKICTHVGCPVNLWEQQTHHLLCPCHQSTFDLGDSGVVVFGPAGRSLPQLPITVDDKGTWSLEATSPFRSARPTSNEILVTTTRRVTTDGPANWHRRRITHPAHRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNC1</accession>
    <name>W4TNC1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="10">PRA-PH</shortName>
            <ecNumber evidence="3 10">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisE</name>
        <name evidence="11" type="ORF">JCM18909_3534</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PRA-PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="3 10"/>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70236">
        <property type="protein sequence ID" value="GAE70236"/>
        <property type="gene ID" value="JCM18909_3534"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE70236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9928" checksum="01C1345BB2F9C500" modified="2014-03-19" version="1">MSKTFEELFAELAIKSQTRPAGSGTVEELDRGVHAIGKKIVEEASEVWMAAEHEGNERLAEEISQEIYHLQVMMIKQGLSLDDVYKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNC8</accession>
    <name>W4TNC8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Imidazolonepropionase</fullName>
            <ecNumber evidence="2">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70037">
        <property type="protein sequence ID" value="GAE70037"/>
        <property type="gene ID" value="JCM18909_3318"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20329" checksum="45CC95216C70CE91" modified="2014-03-19" version="1">MSIVINNIGLLVTNDPSVGTDELGQIRNAAVVICGDRIAWVGPSAQAPAADHQSDMAGACVIPGFVDSHNHPVFAGDRSDEFDARMNGQRYEAGGILRTVRRTREAPIGFLDAVMTGILDEMARSGTTTVEAKTGYGLDVETEVKLARVASSHTDEVTFLALTSSHLSASLMSMSVWCVARCCTPCALCALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND3</accession>
    <name>W4TND3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70042">
        <property type="protein sequence ID" value="GAE70042"/>
        <property type="gene ID" value="JCM18909_3325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6419" checksum="9D687B8084824A98" modified="2014-03-19" version="1">MFDTLGVDPEDVWIMPQGVDGATLLNRARSIAPAVQSHGFNLSLRQQVLMYGNERFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNE2</accession>
    <name>W4TNE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70475">
        <property type="protein sequence ID" value="GAE70475"/>
        <property type="gene ID" value="JCM18909_3802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="262" mass="28952" checksum="8BF8A6127928397F" modified="2014-03-19" version="1">MWMTPPTDSAPGWTTILTGATHEQCNVWWNEFVGHDLARHPDILSQVFFANPSARTLAAATWDAFVSPYGPGPIIHQRVDQQRTGQHQLFGPDLSQGIDRADEQVSSWAAWHLLHEGPDAAVVYFEGVDHAGHSFGADSEQYQQAVGHVDELTRHLVKAVAERHEQLGEQWLVAVTTDHGHKPEGGHGEDEVEVRRSFLAAHHIGGTLPEPLLRTAALRSHEVTPLLLQAMGVHPGHMDASDVGVLRDVEPIGPSREMDFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNE7</accession>
    <name>W4TNE7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inosose dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69739">
        <property type="protein sequence ID" value="GAE69739"/>
        <property type="gene ID" value="JCM18909_2988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9568" checksum="0A6E3CD82C915C53" modified="2014-03-19" version="1">MKIAGAPISWGVCEVPNWGYQMTPERVLTEMKQIGLTATEFGPQGWLPIEAEARATEVKKKYGLKPWERSSCPSCTIRTSIRSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF2</accession>
    <name>W4TNF2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69744">
        <property type="protein sequence ID" value="GAE69744"/>
        <property type="gene ID" value="JCM18909_2993"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18430" checksum="A89126BB8F3D9525" modified="2014-03-19" version="1">MGATHTTFDPEGRWGLTSTTAADQVVLADHIFCPNTIIPESMRAYARELMSNVEDDQNWGMTAGMKSPFVKNGWLSLDDGWHVNSVASTGTTGYTVVGLTHSATASMDDLVETIEGMARIIARHQPRSVTTPSSSTAPTQTTAPKPQAVGDDHGHVSFRAPGTRDIWIQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF7</accession>
    <name>W4TNF7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69749">
        <property type="protein sequence ID" value="GAE69749"/>
        <property type="gene ID" value="JCM18909_3000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="3">
        <location>
            <begin position="446"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="709" mass="75609" checksum="3B1015CF893F9924" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH9</accession>
    <name>W4TNH9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ORF">JCM18909_3604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TNH9"/>
    <dbReference type="EnsemblBacteria" id="GAE70296">
        <property type="protein sequence ID" value="GAE70296"/>
        <property type="gene ID" value="JCM18909_3604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8564" checksum="DCF6B01D6CB1242E" modified="2014-03-19" version="1">MTDTTPNSAPEEPEITYEAARDELVEIVTRLESGGISLAETMTLWERGEKLADICQSWLNGARARIEAARSDAETAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP25</accession>
    <name>W4TP25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70461">
        <property type="protein sequence ID" value="GAE70461"/>
        <property type="gene ID" value="JCM18909_3788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11479" checksum="C7503CDAD1CAEA85" modified="2014-03-19" version="1">MTIARALAQQTGMIVMDEPTNHLDIHHQFKLMHLLRRLNATMVIALHDINLAGRFCDTLVLMSGGSCVACGAPSAVLSPNVLDEVYHVRTNIVRQPNGTVHVAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP43</accession>
    <name>W4TP43_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpH</name>
        <name evidence="7" type="ORF">JCM18909_3232</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69959">
        <property type="protein sequence ID" value="GAE69959"/>
        <property type="gene ID" value="JCM18909_3232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="263" mass="28477" checksum="FF3CE67A947ADF33" modified="2014-03-19" version="1">MTTAVSASQQLDEVGDRRGTGTEFANEIFAVVDVLNRESGLRRAVSDTGSETKARQGLIDAVFTSKVSPDCKELLDATTTCKWRSPAALTRALERQGVRAVLRGARQADRFEAVADELFHVSRLVRGQAALQVALGDPNRSVADRQELLMKLVGGQVSEETLVLARRAVVASDSTFEQVIDGYLHVAAEMADRRRAIVTTAKALTDAQRAEMVKQLERITGSPIELSEVVDPTVLGGALINLGDEVIDSTVAHRLDQARRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPJ7</accession>
    <name>W4TPJ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cys-tRNA(Pro) deacylase YbaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70338">
        <property type="protein sequence ID" value="GAE70338"/>
        <property type="gene ID" value="JCM18909_3652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="3984" checksum="9311F5ECE7C02217" modified="2014-03-19" version="1">MLGQPRVLVSGGRRGLSVELSPSDLVTVTGAVTAKKISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK7</accession>
    <name>W4TPK7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible restriction /modification enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000063">
        <property type="protein sequence ID" value="GAE70671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70671">
        <property type="protein sequence ID" value="GAE70671"/>
        <property type="gene ID" value="JCM18909_4046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24523" checksum="EED8CA53839F84F8" modified="2014-03-19" version="1">MSYSGFFATEDLYEVAHDGNPQKGSWVVPLSRAHDIAQEDFVTVVDDHGARRPRIHRRGEFVFRLSGRARQQSASYYTPEVLTRCTVGQALEELLDDTTTAEEILHLSVCEPALGSGAFAIEATRQLAEQYLTRRQAELGRRIDPKDYPAQLQRTKRTSPYTTFMGSTLTRPRWSSPKSPCGSTPWPAASTPPGSACTCAAETPSLGHATPCIPVTSSLRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM5</accession>
    <name>W4TPM5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70363">
        <property type="protein sequence ID" value="GAE70363"/>
        <property type="gene ID" value="JCM18909_3679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="324" mass="34898" checksum="5ED6C07CE9B5C380" modified="2014-03-19" version="1">MVGHRPAFASQRCGPDDGPRGQGGGGDTERRSVSGEAINGASDHRKRRQAGDSKEGPASRRIRVHGLFQPGGRRTEDGHRMVGLRVRHDVVGDNAQPQTSSPAEQTDGDVAAWRDRHASHLIEIELSSGPGSLLKVSCIVIVRHGQSTWNRQGRIQGQTMGVRLTMRGRGQARQAARAVASLVPHGTPIVASDQKRAVQTARPIARVLGVQVMTDPRLREQGLGAMEGHTADELEPLPQPTGVHPADVRWAGGESLADVAERCHSLLDDLAARHLSATVLVTHGDTMRVLLGILDGRSHRDLDWDLSLTNGSVMVRNVDLGELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ41</accession>
    <name>W4TQ41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70503">
        <property type="protein sequence ID" value="GAE70503"/>
        <property type="gene ID" value="JCM18909_3831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4382" checksum="95EA893F31FF95B9" modified="2014-03-19" version="1">MADPQRCREMGCAGRRAVESGLNFESQAEALTDLVTGLLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ57</accession>
    <name>W4TQ57_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70518">
        <property type="protein sequence ID" value="GAE70518"/>
        <property type="gene ID" value="JCM18909_3851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="213" mass="22805" checksum="68786EAC8C654CB2" modified="2014-03-19" version="1">MASVVRQFFEIAPRARVVNLYGATETSANTTSFEVSRSGSIPDPIPLGKPICATKIVIRDMKGNEKLSGEEGQICVQGAPVADGYIVNGQLSLGDDAFFTLGSGQREIRTGDLGIIKDGVLSLVGRLDNAVNIAGHKIHLEEVERAAARVANSTKQCGAVYHQGSGGVLALVIPREWESQVTTSRLAEFLPSYMIPLKIVTTQNVPRSRTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQH5</accession>
    <name>W4TQH5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ChlI component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000061">
        <property type="protein sequence ID" value="GAE70658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70658">
        <property type="protein sequence ID" value="GAE70658"/>
        <property type="gene ID" value="JCM18909_4029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11378" checksum="3E670F67B97A889C" modified="2014-03-19" version="1">MHGESDPAVRAEIIRRRLDHDADPAEFDHRWQNDQNRQAAVIERARHIVAGVQLDEVVTELISCLCRQNHVAGHRADIVMAEATRPMPPWPVAASPPRTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQV1</accession>
    <name>W4TQV1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70619">
        <property type="protein sequence ID" value="GAE70619"/>
        <property type="gene ID" value="JCM18909_3973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7089" checksum="07BF1C2198869E78" modified="2014-03-19" version="1">MPENEDELTRNDDKAARNTLGRRTFLGGVTLVAAAAVAGTTQRWPMRRSVSIPRPAPPLNRWVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR07</accession>
    <name>W4TR07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribose 5-phosphate isomerase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000065">
        <property type="protein sequence ID" value="GAE70679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70679">
        <property type="protein sequence ID" value="GAE70679"/>
        <property type="gene ID" value="JCM18909_4055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9447" checksum="3196711438A1C739" modified="2014-03-19" version="1">MGMAITANKVPGIRACTAHDSFSVERLIMSNDAHVLCLGQRVIGRELARRLAHEFIGYTFDPSSHSKANIDLINAYESGAGETAPGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDN4</accession>
    <name>W4TDN4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JCM18909_95</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67060">
        <property type="protein sequence ID" value="GAE67060"/>
        <property type="gene ID" value="JCM18909_95"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="UniPathway" id="UPA00544"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE67060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="204" mass="22890" checksum="2C78811D4FCFE862" modified="2014-03-19" version="1">MATKKDRPSSINVPNALTLLRVVAVPIFGWMLLAHAYEGGWRTATTIVFMVAILTDFVDGKVARKYNLVTNFGKIGDSIADKALTGMAFIGFSIIGELPWWMTITILLREWGITVMRMKMLKYEVMAANKGGKLKTAMQSLAITLFCLGLWRMPTFVYVIAWAVMIIAFVLTVITGLVYIRDAIHIRNRAKMPESRPARKCTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDX4</accession>
    <name>W4TDX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aromatic amino acid transport protein AroP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67160">
        <property type="protein sequence ID" value="GAE67160"/>
        <property type="gene ID" value="JCM18909_202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="5659" checksum="30159F786F5469ED" modified="2014-03-19" version="1">MIVITNLKFRRRIGPEGVAALEFRMPGNPVTSYVVLVFFSRSWWSSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE02</accession>
    <name>W4TE02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67190">
        <property type="protein sequence ID" value="GAE67190"/>
        <property type="gene ID" value="JCM18909_233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="13144" checksum="DD9D9548014FA0A6" modified="2014-03-19" version="1">MNRRELIRASGITEAMLMELERHQLVRPKRGASYFGQEALVICVAARRLAAYGMDTRHMRAIRQAAEHEAGLIEQALIPHARHPEQASKIAAETTKVMMHAHTAMVYDMLEHWSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE53</accession>
    <name>W4TE53_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="2" type="ORF">JCM18909_290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67245">
        <property type="protein sequence ID" value="GAE67245"/>
        <property type="gene ID" value="JCM18909_290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11655" checksum="0354A568D0FCF47F" modified="2014-03-19" version="1">MPSTRRFIVALTPDDVVRLAGLARIDLTDDETAYLAPQLDAILDAVAAVSGVATDDVPPTSHALPLSNVFREDVIKESMSSHDALAMAPRSENQRFRVPRILDEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEG8</accession>
    <name>W4TEG8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Division initiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67186">
        <property type="protein sequence ID" value="GAE67186"/>
        <property type="gene ID" value="JCM18909_229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27460" checksum="FABD122D424A3E82" modified="2014-03-19" version="1">MPEHHDRREWAENHWRKIGKDLASVSTGQILVAIILCLCSFMVVTQVRSRHDQDAYSTMSRADLVTMLDSLSDSSRQLDSEIADLRATTRDLQSGADSRKVARQEAEERLTRMKILAGTIPVHGPGIKITINDPEDKVTSDMVLDAVEEMRDAGAEAMVLNNKVRIVADTWFAASPDGLQVSGTTVTRPYTLTIIGQPHALKEGAKFRGGLVSQMESDKVGVSVEVTTSRDLTITAVARPQPMTHATPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEP9</accession>
    <name>W4TEP9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67420">
        <property type="protein sequence ID" value="GAE67420"/>
        <property type="gene ID" value="JCM18909_479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6456" checksum="073F0914E35E0E56" modified="2014-03-19" version="1">MEGTSQAAPHVSAVVALMIAANPNLTPARIKEILKQSVNPAKCKTGCGAGIVDARKAVKAAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEQ5</accession>
    <name>W4TEQ5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bioD</name>
        <name evidence="6" type="ORF">JCM18909_37</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67007">
        <property type="protein sequence ID" value="GAE67007"/>
        <property type="gene ID" value="JCM18909_37"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="234" mass="24502" checksum="04F41BCF29005072" modified="2014-03-19" version="1">MNITDLNGIVIVTGTDTDVGKTVTTAVIASALKQSGKDVTIIKPYQTGLDHDEPGDVHDAGWLASIDADNVLEYVRCPEPLAPTTSAARAGMTIPSIEEVATRILVDSDGHDATLVEGAGGVLVGLDNDGSGVLDLMDAFTRRGHEPHVIVVTRSVLGTLNHTGLTCHAIRDRGHQVDAIVIGSWPDRPDLAERCNLEEIEDAAGAPLVGVIPAGIGKDPEAVQQTARNLGETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEX4</accession>
    <name>W4TEX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-i(6)A37 methylthiotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67077">
        <property type="protein sequence ID" value="GAE67077"/>
        <property type="gene ID" value="JCM18909_112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="252" mass="28020" checksum="CA7450A8ED444B77" modified="2014-03-19" version="1">MRFTSPHPAAFTDDVIEAMAETPNVMPSLHMPLQSGSDEVLRRMRRSYRSTKFLGILDRVREAIPHAAITTDIIVGFPGETDKDFAETMRIVEESRFSAAFTFQYSIRPNTPAGVMEDQVPKPVVQERYEQLVELVDDIAWQENKAQVGRAVEVMFAQGEGRKDEATHRVTGRARDNRLVHVSLNPGDDVPRPGDIGEVVITSGHPHHLVADGGLMNLRRTRGGDAWHARQGQESRGTPTMLGLPTVGVPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEY7</accession>
    <name>W4TEY7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67520">
        <property type="protein sequence ID" value="GAE67520"/>
        <property type="gene ID" value="JCM18909_585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7908" checksum="C7B5E744F286293D" modified="2014-03-19" version="1">MCRCGEIGCEYRREHLFESRVLGASTATYFLPSAMLREYIALLASRPWINGIMLVLVLAFWPIVTMALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF06</accession>
    <name>W4TF06_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigA</name>
        <name evidence="9" type="ORF">JCM18909_145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67107">
        <property type="protein sequence ID" value="GAE67107"/>
        <property type="gene ID" value="JCM18909_145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="135"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="5">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="303"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="159"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="368" mass="41493" checksum="285F957354A2BA52" modified="2014-03-19" version="1">MERDGDDVVLTIGGKKRSLDDVDERDYDPAEAAKDEQQINKETEAFSLSDNDDADEPEQTVMVAGATADPVKDYLKQIGKVALLNAVEEVDLAKRIEAGLFAGEQLADPDAKIREKDREDYEWIAEDGKVAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIKQAITRAMADQARTIRIPVHMVEVINKLARVQRQMLQDLGREPTPEELANELDMTAEKVIEVQKYGREPISLHTPLGEDGDSEFGDLIEDSEAIVPADAVNFTLLQEQLHDVLDTLSEREAGVVSMRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF07</accession>
    <name>W4TF07_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aroK</name>
        <name evidence="3" type="ORF">JCM18909_421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67371">
        <property type="protein sequence ID" value="GAE67371"/>
        <property type="gene ID" value="JCM18909_421"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18013" checksum="F25DBE13C7136B5D" modified="2014-03-19" version="1">MIALIGAPGSGKSTIGPLLAQRLGEEFVDVDAAIEQAEGRDIPEIFLIDGEPYFRKVERRETLAAIERGGVVSLGGGGSGDVEVGNALERVCVVWLDVSARTAADRIGLKDSGRPLLGGQVHSQLVRLMKERRAVYQRPATIRVAADTLSPEQVVDVIVSELADLEEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF32</accession>
    <name>W4TF32_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ORF">JCM18909_59</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67028">
        <property type="protein sequence ID" value="GAE67028"/>
        <property type="gene ID" value="JCM18909_59"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="116"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="242"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="332" mass="35260" checksum="4D7C9A05EEB4E866" modified="2014-03-19" version="1">MTAIKTRPVHGYSRFLSTGSACGSRVVTNEEMCTLIDSTPEWIEQRTGITERRWATSSETVASMGTTAARTALERSGLEASQIDAIIVATVSHHRPSPSLAAYIARELGLGDAAAFDLNGACAGFCYSTALTDSMIRTGSANYVLVIGVEKLSEMTNLDDRSTAFLFSDGAGAAIIGASDEPGIGPVVWGSRSDQLKTIELEDWPTASADPNKIHPLIRMEGRAVFKWAMTDVAKRAAEAVAEAGITPADLDVFIPHQANDRITDVVSRHLKLPESVTVCHDIADMGNTSAASVPIAIDRMLQRGQARSGDLALIIGFGAGLVYAGQVIRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF71</accession>
    <name>W4TF71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysine-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_464</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67406">
        <property type="protein sequence ID" value="GAE67406"/>
        <property type="gene ID" value="JCM18909_464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="13"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="474" mass="50400" checksum="BAEAB7741EC321F0" modified="2014-03-19" version="1">MDGELKRGLSSRHMNMIAIGGAIGTGLFVASGATISQAGPGGALVAYFAMGLMVFLLMQSLGEMSSYLPVPGAFETYATRFVSPSFGFALGWNYWFNWAITVAAELAAASIVMAYWWPGVPAWMWSVGFLALLFLLNVLSARAYGESEFWFAIIKVTAVIVFLVLGILMIAGVMGTSPGLSHWRRGDAPFVHGFGGILTVFLIAGFSFQGTELIGIAAGESKDPGMTIPKATRQIFWRIMIFYIGAIAVIGLLLPYTDPHLLAGEVTDVAVSPFTLVLKRAGVAAAAAVMNAVILTSVLSAGNSGLYASTRMLYALAREGKAPRILGRTSRRGVPVPALIVTTLVGAACFATSLVGSGQAYTWLVNISGLCGFIAWIGIAICHIQFRRAFQAQGHDLSELPYRARWYPAGPVVAGVLCVIVTLGQGRDAVLSGDVTDMIVAYISIPVFLALWVGHKIVTKAPRADLSTADLHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS6</accession>
    <name>W4TFS6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67288">
        <property type="protein sequence ID" value="GAE67288"/>
        <property type="gene ID" value="JCM18909_334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004501">
        <property type="entry name" value="PTS_EIIC_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51105">
        <property type="entry name" value="PTS_EIIC_TYPE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-3" evidence="9">
        <location>
            <begin position="11"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="198" mass="21593" checksum="4BBBB68B7B32F893" modified="2014-03-19" version="1">MIAMEKFFNFLDRRVAAPMSMISEQRHIRAIRDGVISAIPFIIAGSLILIIAAPPIPETSGFAMWAKDHAEQILIPYRMTFGIMSLYVCFGVGSSLAHSYDLDGLAGGQLGVAAFLLSLTPKTFGDGIYVALESLDSKGLFPAMILALLAVEVMRICYKHNLTFRMPEQVPESVSRSFGAVIPAFVIMGIMTLISVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFU9</accession>
    <name>W4TFU9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">JCM18909_730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67656">
        <property type="protein sequence ID" value="GAE67656"/>
        <property type="gene ID" value="JCM18909_730"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="198"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="517" mass="55604" checksum="1F189BCE9092889B" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ1</accession>
    <name>W4TFZ1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_89</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67054">
        <property type="protein sequence ID" value="GAE67054"/>
        <property type="gene ID" value="JCM18909_89"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="20559" checksum="140B0022E438CFA6" modified="2014-03-19" version="1">MELFYAAGPSVVTSLKEAGHDVFCDLKLHDIPNTVKGAASSLSKLGADLLTVHAAGGRSMMEASLEGLGDAAETTRVIAITQLTSTSPEALKTEQLVDVPLVESVRNYVKLAQAAGLAGVVCSAHEAADIASVTGPNFLRVTPGIRPAGSAVGDQSRVATPGNAASMGSSAIVVGRPITKADDPVAAYHAIRDDWNAGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG68</accession>
    <name>W4TG68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Duplicated ATPase component BL0693 of energizing module of predicted ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67786">
        <property type="protein sequence ID" value="GAE67786"/>
        <property type="gene ID" value="JCM18909_869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="4598" checksum="9AE9AA3AF6E9B06F" modified="2014-03-19" version="1">MSIADLVGELATAGKVVIVITHDPELMARCGDFLVNIATLKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK0</accession>
    <name>W4TGK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67543">
        <property type="protein sequence ID" value="GAE67543"/>
        <property type="gene ID" value="JCM18909_609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9426" checksum="1E1BC07AE08DF29A" modified="2014-03-19" version="1">MGHGIPPAIDLHRDSVSRGSSMLPVDEDGITLLGDDPSTFVTGPPTQYWMVVITLDADLLTWRSRFGPWEPLLIGHSGTTRGRPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL4</accession>
    <name>W4TGL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67294">
        <property type="protein sequence ID" value="GAE67294"/>
        <property type="gene ID" value="JCM18909_340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HHH_6" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="210" mass="23190" checksum="3A19E90A3DE2B3B6" modified="2014-03-19" version="1">MGAVRNVGANAVAEIIRAREENGPASDFFHFPRSVSLTVCNKRLIESLIKAGAFDSMGHSRRGLMAVYGQAVDAVIDIKRNQANGQDDLFGMGDDSLPTQMGVERVVPDDDWDRSTKLAFEREMLGLYVSDHPLRGLEAALEAESDISVAELVNPEGHHEAGTPWSAWSPRSCGVRLRTVTFGPQRPWRTLMRPSPSPVSQRFISEWNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM9</accession>
    <name>W4TGM9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duplicated ATPase component CbrU of energizing module of predicted cobalamin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67578">
        <property type="protein sequence ID" value="GAE67578"/>
        <property type="gene ID" value="JCM18909_649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="110"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="235" mass="25246" checksum="B937A8C61CF858DF" modified="2014-03-19" version="1">MILAEHRLERVMHAADALWWLPGDGSVVQGRPEEVLARADVVPPLAALSRAMGWPTVPLSVREARRRVGPRPGLPRAPQPSEAMTWPGGGDEVLRLETLGVNYGQVRAVDALTTTVERGTITCLMGRNGSGKSSLMWAIQGATKSSGRVLVNHEGSWAAPRKADAATARRMVSLVPQSASDLLYLPTVAEECAQADKESGVPAGTTRAILSRLRWNCRKIAIPGTCRKASDWPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN0</accession>
    <name>W4TGN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68125">
        <property type="protein sequence ID" value="GAE68125"/>
        <property type="gene ID" value="JCM18909_1242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="10194" checksum="44D75B212F9FC198" modified="2014-03-19" version="1">MSRPRRAFEVRPSQVVADRMAHQVMSTIKRTSRRVIICNPYYELHDDGGSFSPESRYASITSVCNYYAVWRDDHPSCYLPATSLADGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN1</accession>
    <name>W4TGN1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67692">
        <property type="protein sequence ID" value="GAE67692"/>
        <property type="gene ID" value="JCM18909_770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6028" checksum="EBAF0131E950741F" modified="2014-03-19" version="1">MTTGLYPAKGDVWGFGEMVLTGTDVEVATVLVKRRRVACMTPVYRWQPEAGRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR4</accession>
    <name>W4TGR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67344">
        <property type="protein sequence ID" value="GAE67344"/>
        <property type="gene ID" value="JCM18909_392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021229">
        <property type="entry name" value="DUF2800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10926">
        <property type="entry name" value="DUF2800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="4928" checksum="FD31E535752D2F05" modified="2014-03-19" version="1">MGKQTFHEILGDFVTKPAGKLTLVPASDKRPALDLVSAATDFQPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGX6</accession>
    <name>W4TGX6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamyl-tRNA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68021">
        <property type="protein sequence ID" value="GAE68021"/>
        <property type="gene ID" value="JCM18909_1127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="4875" checksum="9048B7074A4CBEE5" modified="2014-03-19" version="1">MTVDHAEQGLGVVSEAAAQIDGLGLALTDHPDPGRPCAVNVQPGVPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY4</accession>
    <name>W4TGY4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67688">
        <property type="protein sequence ID" value="GAE67688"/>
        <property type="gene ID" value="JCM18909_766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8531" checksum="7947B05371352C64" modified="2014-03-19" version="1">MGRWTLPVALLPVVGLGIHDGSGWDASCWAGGRESDGAGVVWSEEEQPANRPVAVHNPSTATWRLTPRMLVRCPRRGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY7</accession>
    <name>W4TGY7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67693">
        <property type="protein sequence ID" value="GAE67693"/>
        <property type="gene ID" value="JCM18909_771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20479" checksum="9DB7791A8FE09E98" modified="2014-03-19" version="1">MCGDGVTVTTMTALGRQALAVTARWLRDGLCSGKKGRSNSLVVPWFSCQTMITPWQLEGYRVRRLPVGHDFQLDADALADALATCRRQGEHPAVLTCETFGIQPSSKLVEVLKQARRDGVPVVVDRTHSFLAPSLTPADIEVVSTRKLLPLAEVAWVQADDDLSELVGTRDNKDVFLTRARRRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH02</accession>
    <name>W4TH02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67812">
        <property type="protein sequence ID" value="GAE67812"/>
        <property type="gene ID" value="JCM18909_897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010799">
        <property type="entry name" value="MlrC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015995">
        <property type="entry name" value="MlrC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07364">
        <property type="entry name" value="DUF1485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07171">
        <property type="entry name" value="MlrC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1485" evidence="2">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="MlrC_C" evidence="1">
        <location>
            <begin position="255"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="358" mass="38382" checksum="F0128994DFD4CDDB" modified="2014-03-19" version="1">MPTKRPWNHDVEWVPILHCSALPGGPVERLTYEKWRAEICDGLAKAGHVDGIFFDIHGAMSVPGYDDVEGDLISAIRDVVGPEPMVGASMDLHGNVSEKKLFAGCDLLTCYRMAPHEDAWVSRERAARTLCERLRSGKGKPIKAMVTVPILLPGEKTSTRLEPAASLYGMVPEVAAHDGVIDVGVWIGFAWADQPRCTAAVVGFGDDENRVRDGVSEIAQFFWKVRREFVFVAPTDGIEEAVDRAVASSRRPFVISDSGDNPGAGGADDVTIALSVLLTHPEITGGELSAIYASIYDPQVVKRADKAGVGGMVEVDLGGHVDTRKPGPVHLSARCVASLTILAACVRQCWESGGLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ9</accession>
    <name>W4THJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67649">
        <property type="protein sequence ID" value="GAE67649"/>
        <property type="gene ID" value="JCM18909_723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="5">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7561" checksum="FCAC89F397977A49" modified="2014-03-19" version="1">MVTPRVFFDMIARLKAEPAAQWVDVVAGNIATYEAAKALCAAGVDGIKVGIGPGSICTTRVVAGVGVPQVTAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU1</accession>
    <name>W4THU1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67988">
        <property type="protein sequence ID" value="GAE67988"/>
        <property type="gene ID" value="JCM18909_1092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11551" checksum="606D52150B7C0777" modified="2014-03-19" version="1">MTVSSGPRVRFFGLFGVLLIVQRRLGVSTRELWVVLAINAALLLFISGIAWQAHLGGFLVGMMCGVIFFEDPKRIQAGKSAQTWPRMALLLFAMVAALVVKYLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI35</accession>
    <name>W4TI35_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1207</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68093">
        <property type="protein sequence ID" value="GAE68093"/>
        <property type="gene ID" value="JCM18909_1207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="267" mass="29011" checksum="2C5DD5144F6BECDC" modified="2014-03-19" version="1">MGFNFANPRIPLGSWIETFFDWFQNAFDWLITFTNVVIGGMYHGLNLVLSKPLYLVMMVVFAAIGWACANWRVGLFAFIGFYLVRSMDQWNNTMQTLALVVVAVILALILAIPLGIWAAKSKRFSAIIKPILDFMQTMPSLAYLVPVIVLFGIGQVPGAIATIIFALPPGVRFTELGIRGVDTETVEAGAAFGASPRHILWHIQMPLAMPTVMAGVNQVIMLALSMVVLSGMVGAGGLGGDVVAALSQVDIGLGMELAWRWLSSLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB6</accession>
    <name>W4TIB6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rossmann fold nucleotide-binding protein Smf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68173">
        <property type="protein sequence ID" value="GAE68173"/>
        <property type="gene ID" value="JCM18909_1292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="391" mass="40710" checksum="7D3EF39C2EC0A218" modified="2014-03-19" version="1">MCGGGHGNATREIAMTWTSEKLARAALTAAAEPGVMAKRLVEMTAEELWQHMLTDSGERWHKRAKSLDVDQLVERSEKAAMRFLIPGDKEWPTGLDSLARVGKSGMGGAPVGLWVMGPAHLADISQRSVAIVGCRSASSYGQDVAVEMAYHLVRGHCDGTGSHTVISGGAFGIDVAAHRGALSARGNTVSVLACGLDTLYPRGNSAVLEQIAGTGALVSELPLGRHPTRPGFLARNRLIAALTTGTVVVEAGWRSGAINTASWANALGNAVMAVPGPVTSSRSTGTNKLIRDGEAILVRDADDVRGIVGELAPEPERPAGRSLPTDILDATELAVHEALPAHGSCGLDELAVLAGVPVAQCSAALSVLEQLGMAACCLDGTWSVTLARERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE7</accession>
    <name>W4TIE7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68546">
        <property type="protein sequence ID" value="GAE68546"/>
        <property type="gene ID" value="JCM18909_1692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="3">
        <location>
            <begin position="125"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="295" mass="31595" checksum="6B75EAE76211B8F8" modified="2014-03-19" version="1">MEAIDNAKAVTDKPSFIRLTTVIGWPIPKLAGLAQVHGAKIGTEGVSALKKKLGFEDKPFAIDLEMVQQVRAAFAERGKGLREVWDEKFAAWHDANPDGAALLERMLAHKLPDDLGIPTFEPGKMSTRKASGAVLSALGPQLPELWGGSADLAGSNNTTMKGADSFLPEDRCSEKDPGGPYGRTIHFGVREHAMGGILNGITLSGLTRCYGGTFFVFSDYMRPAARLAALMKVPSIFVWTHDSIGVGEDGPPTSRSSTWPPTEPSRDLTSSVPPTPTRPPWHGAPSWSTLTVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF4</accession>
    <name>W4TIF4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68317">
        <property type="protein sequence ID" value="GAE68317"/>
        <property type="gene ID" value="JCM18909_1446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12162" checksum="83494551ED420DF5" modified="2014-03-19" version="1">MFPQTGVAVTTLLERLGCKVEFPREQTCCAQMTTNTGYFDEGIPTVRQYVRAFGDYDYIVAPSGSCVAAVRDQHPMLAEYAGDSGLAKEVEHTSQCTYDLPSSSSTFSGSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIQ0</accession>
    <name>W4TIQ0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68014">
        <property type="protein sequence ID" value="GAE68014"/>
        <property type="gene ID" value="JCM18909_1120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="18476" checksum="FC59E28A6C533C61" modified="2014-03-19" version="1">MSAIRLGTRASTLATTQSEMVAGLLRSEGLDVDLTTITTHGDTSTASLAAMGGIGVFTSAIRAALLEGEADIAVHSFKDLPTGRPLGLAIGAVPARADPRDALVARDGLTLHDLPQEASVGTGSPRRAAQLLAVRPDLTIVDIRGNVDTRWVASRDSAATPKVVARRTSTPSCSRRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR2</accession>
    <name>W4TIR2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA integrity scanning protein DisA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">disA</name>
        <name evidence="12" type="ORF">JCM18909_1135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DisA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68029">
        <property type="protein sequence ID" value="GAE68029"/>
        <property type="gene ID" value="JCM18909_1135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01438">
        <property type="entry name" value="DisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023763">
        <property type="entry name" value="DNA_integrity_scanning_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE68029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40581" checksum="5E0970C34A8CDB91" modified="2014-03-19" version="1">MNDVQPDPETSREMQAEQVRHLMALLAPGTPIREGLDRIVNGRTGGLIVLGDGPEINGVCSGGFPLDVRLTPQALRELSKMDGGLVVSSDHERIKAAAVHFVPDGSLPTLETGTRHRTADRLSQQTGAPVVVVSASMSVMSLFLNGRRYLIERPEQLLARANQALATLVSYRGRLVDEAENLTTLEIRDQVQVRDVAAVAQRFEMWRRIDVEVRRYVSALGVEGRLVQLQRNELSLGVEDLGRLLTDDYRPNSVAPGGFSLSGLQKLSWEDLLNVTKVAETINLGPAEHPLDSPIRARGHRQLTLMTDLSSRTIQRIIDHFNDLQSLVSASTSELGDIKGVGLRRAREIRQGLESIFEGDQRTHHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV9</accession>
    <name>W4TIV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68890">
        <property type="protein sequence ID" value="GAE68890"/>
        <property type="gene ID" value="JCM18909_2061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022521">
        <property type="entry name" value="CHP03815_CpaE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03815">
        <property type="entry name" value="CpaE_hom_Actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="22359" checksum="7C233E007BBA7DF0" modified="2014-03-19" version="1">MLVGADMAGSVMAWGLSPRPGTHVVGFDAEEAARWSAGLSASVIVVPRANQVLTEILHDELATTSRATVVQVTSSGGGTGVSTLASGLAWAAARSGMKVGLVELDPSAGGIDLLLGIERKEGWRWPELASARGVTTDLGSHVPSLDGVEVVSAGRVGVHVPPAARRAVVDSLAGDHDLVVVDPGGLDTPEVTVNVKVGVVAADLRSVMTARGRTFRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ75</accession>
    <name>W4TJ75_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68841">
        <property type="protein sequence ID" value="GAE68841"/>
        <property type="gene ID" value="JCM18909_2006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Gate" evidence="2">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19398" checksum="0E28A5A4A8CA8E7B" modified="2014-03-19" version="1">MLTTIVIWALTTFPMRSNAELTKAGIDPSNDVAVAAYTMDHSIAGSIGKAVEPVFEPLGFDWRIDVSLIGSLAAREVSVSTLGQMASATDPEDDVDVSHQLDHWTWTHGPNKGNKVFTPATIVALILFFAYALQCMSTVAIMKRETGGWKWPAVAFGYMFVLAWVMAFIGRLVTGLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA0</accession>
    <name>W4TJA0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Neuraminidase NanP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68234">
        <property type="protein sequence ID" value="GAE68234"/>
        <property type="gene ID" value="JCM18909_1357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="348" mass="38840" checksum="8C78A8EBD5DF385E" modified="2014-03-19" version="1">MVSVTGTVASFHHSEWIHVDALQAWSGVEAFDERHWDLIDKAVELAASAGVDTLFTPILTPPIDVDPTSPPLATQLVVVHRQGDRWSFDFDRLDRWSRIARRHGITHLEFSHLFCQGEVDRPADVYDADGNHLFGSHLPTEGYRDFLAVLLPALDQWSRRHGWSDALYWHVSDEPRANQYTSYREAVDMVRRTVPGATVIDAVDDPRFATAVDVPVTIYGHLLECEAAGLDGMWAYTSCASTFWEPNRHLGMPLTRLRAWDCCCGGTTPPVCCTGPSTSGSISFRATSSIPTPTPRLTWPFPPVIARSSTPCRWFPRAFAAIEGSRTAPRGRPTVAACRRCGRPPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE3</accession>
    <name>W4TJE3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68533">
        <property type="protein sequence ID" value="GAE68533"/>
        <property type="gene ID" value="JCM18909_1678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="11312" checksum="EE128A7AAC3F6102" modified="2014-03-19" version="1">MGLVQGWLNIVEGSAMPPTRRELTKKNVRGEEAARRNLRRMPLTYTTSRPWHPDSISSHHLARGWCDENCRVPQRPSSVRNLSASRAARHPDPAAVTACW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE9</accession>
    <name>W4TJE9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68543">
        <property type="protein sequence ID" value="GAE68543"/>
        <property type="gene ID" value="JCM18909_1689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8270" checksum="07D7210BB199CAD0" modified="2014-03-19" version="1">MLRIAVLGAGVMATALTFPAVENGNEVRLIGTHLDDDIIDSIQPLGSTRFLNLRLTNASRRTVLLTPPRPSRGLTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJF3</accession>
    <name>W4TJF3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68548">
        <property type="protein sequence ID" value="GAE68548"/>
        <property type="gene ID" value="JCM18909_1694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8128" checksum="6DD614ECE4FC59BF" modified="2014-03-19" version="1">MNNNYVVGLDFGTLSGRAVVVRASDGAEMGAAVHEYPHGVMDRPLSAADGRKLPPDFALQDPVDYLETLRRSSVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ0</accession>
    <name>W4TJJ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">8-amino-7-oxononanoate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69125">
        <property type="protein sequence ID" value="GAE69125"/>
        <property type="gene ID" value="JCM18909_2313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="335" mass="35159" checksum="F9014DDB82D70BA9" modified="2014-03-19" version="1">MMNTVRRLGSSSGGSRLTTGTSVAHHQAEHEIAAWLRYPQAVFMASGYQANIATIQLLADPHVTVISDAENHASLIDGCRLARARTVVVPHADLDAIDTALDRVTTDRALVLTEGVYSMGGDVTAVGELVEIAHRHGALVVVDDAHGIGTVGPTGRGATEGLSASQRPDVLLGTASKALGVEGGFACVDETLATLMRNCARGYVFSSAPSPVVAAGVAAAVEYLRTDTRRVCSLQANVAQARRLLAEADLIPPSTAHDRGPIIRIPVGPESRAVAAQGELARRGLMVGAIRYPAVAKGDAILRICLTARHTDEHIRILVMSLREVLDGALSDAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU5</accession>
    <name>W4TJU5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69061">
        <property type="protein sequence ID" value="GAE69061"/>
        <property type="gene ID" value="JCM18909_2244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="17543" checksum="0A6263F145F7EBA5" modified="2014-03-19" version="1">MEVWSRVTRLARRLDRDRAKAFSQWDLEGWEFDVLAALRRSGEPYQLSPGQLLNELEVASGTMTNRITRLSNRGLVRRLPHPKDGRGVIVELTDEGRDRVDGAWQPCWSPRDVCSTRWMPRSLNRWVKVYVPCWPVMRNWTEGFLSRCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU8</accession>
    <name>W4TJU8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="12" type="ORF">JCM18909_2424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TJU8"/>
    <dbReference type="EnsemblBacteria" id="GAE69230">
        <property type="protein sequence ID" value="GAE69230"/>
        <property type="gene ID" value="JCM18909_2424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE69230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12484" checksum="32345B7CAAF11FC5" modified="2014-03-19" version="1">MTETTPEGIVNPPIDQLLEHVDSKYRLVLFAAKRARQINAYYSQLAEGLLENVGPLVETTNQEKPLSIAMREIQAGVVEAHEMDAEEIAAQAAAAQEAPAIELDDPFADLADPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV2</accession>
    <name>W4TJV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription termination protein NusB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69235">
        <property type="protein sequence ID" value="GAE69235"/>
        <property type="gene ID" value="JCM18909_2429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8105" checksum="EE24329C94542425" modified="2014-03-19" version="1">MSTNTVPTPDDEGPTEWIGDLEVRRVSGDIQKHADLSTRSKARKQALDILFEADLIGTDPLEVLAARPGAFTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY2</accession>
    <name>W4TJY2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69106">
        <property type="protein sequence ID" value="GAE69106"/>
        <property type="gene ID" value="JCM18909_2294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14957" checksum="29529463A80B5AB7" modified="2014-03-19" version="1">MRLGPLELGLCHWGSFWNVARLCTGRVMWIFLGGSQERFWTGPRPEVRELFLLFCTCPGIVKPGLSLLLATMHQPPPRLHAGSMTRRATWQRAPPSLEERRLLQIVFCPLATATTVRWVSARRRRHRGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK08</accession>
    <name>W4TK08_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68867">
        <property type="protein sequence ID" value="GAE68867"/>
        <property type="gene ID" value="JCM18909_2037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13282" checksum="41FDED1AC15580BA" modified="2014-03-19" version="1">MDFKDDPSHQKPAVEGNWPAGAKDSRILVRCNVGGQWASPKGDGRTESLKAVGITYAPDGGMSLIHMVNGVTDNPDLGKYWMYSMASKPGGKWDMMVPTPGKNTWVGVTLGGQEVPSIVPPVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK21</accession>
    <name>W4TK21_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplO</name>
        <name evidence="8" type="ORF">JCM18909_2335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69146">
        <property type="protein sequence ID" value="GAE69146"/>
        <property type="gene ID" value="JCM18909_2335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20736" checksum="67F4123D59A980A0" modified="2014-03-19" version="1">MAIELHDLKPAPGAHKAKTRVGRGEGSKGKTAGRGTKGTGARKNVPEFFAGGQMPIHMQAPKLGGFHNPFRTEYQVVNLDKVEALFPKGGKITVDDLVSVGAVRDNELVKVLGTGELTVKVDLVVDAWSKSAQEKNRESWWQRYQTLTSSRHRYDRLATGGRGNTVFPLPPVVYQLTAQFQRRRTSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK33</accession>
    <name>W4TK33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68484">
        <property type="protein sequence ID" value="GAE68484"/>
        <property type="gene ID" value="JCM18909_1625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="7987" checksum="17E1DD90D620769D" modified="2014-03-19" version="1">MKKPPATLDLESPTEERELQRGLTNRHLQLIALGGAIGTGMFMGSSSTIHLAGPSSALVYALIGFFPLLHDASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK48</accession>
    <name>W4TK48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68808">
        <property type="protein sequence ID" value="GAE68808"/>
        <property type="gene ID" value="JCM18909_1971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="244" mass="26405" checksum="168FC331808C92CE" modified="2014-03-19" version="1">MSSYLAPPVSVVIPVRNEERYLEESVAGVLNQGYPGPMEIILAIAPSTDRTAEIAQDLAVRDDRIRVIDNPDGTTPKALNLGVAVSQYDIIVRVDAHGELGPEYIAIAVELLERTGAANVGGIMDAKGRTPFEQAVAVAYTSKLGLGNSAFHQGDAPEGPAETVFLGVFRKADLEAVGGFCPEFDRAQDWELNYRLRQSGREVWFSPNLRVTYRPRSTVKALAKQFFSVLASGVARSCAAIAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK65</accession>
    <name>W4TK65_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68823">
        <property type="protein sequence ID" value="GAE68823"/>
        <property type="gene ID" value="JCM18909_1987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="PTHR13414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="27277" checksum="236CD40E543B494E" modified="2014-03-19" version="1">MSQAHAAQRPNGAKEPANSTQGGRTAIIAAASANLAIAVTKAIAWALTGASSMLAEAIHSVADTANQVVLMMGGKESHKEADEDHPFGYETARYLSGFIVAIVIFTLGGLFALYEAYHKIDATLGGHPDELLDSQWWWVPLAVVMISLCAEGASLRTALKESSQDREGMTILQYIRKAKAPELPVVMLEDSAAVLGLIFAFLGIGLTLLTHNPIFDGIGSACIGILLVVVAGVLSREMKSLLEGESATPESRKAVYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK85</accession>
    <name>W4TK85_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68554">
        <property type="protein sequence ID" value="GAE68554"/>
        <property type="gene ID" value="JCM18909_1700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9528" checksum="48E491A86A469A94" modified="2014-03-19" version="1">MQFFPLLMGKTFTTYHWTYTSSWDSHTWGMATVALAIAAFFGVFTAGLGEFCARLWYNRGTSHIDPPAAAIWLGNTVVVSLATLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG8</accession>
    <name>W4TKG8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69435">
        <property type="protein sequence ID" value="GAE69435"/>
        <property type="gene ID" value="JCM18909_2649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848800" evidence="1">
        <location>
            <begin position="31"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="9922" checksum="FFF938848CA30056" modified="2014-03-19" version="1">MDSFVALLGSVWYLVLVAAVSPVMILNANAAVHGQKQNTVGLLSLGQVWCLAPSASRVSACWEALPPTSPLVSWPHVPSTVYWAFYSSYSAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ2</accession>
    <name>W4TKJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68679">
        <property type="protein sequence ID" value="GAE68679"/>
        <property type="gene ID" value="JCM18909_1830"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="64"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30868" checksum="41243AC7DCDC91C3" modified="2014-03-19" version="1">MNHRESQPVIPAHAQPLETADPRAASIDGVVAITNAVRSAVAGAIEGKSERIDTALVVLLAQGHLLVEDVPGVGKTTLARALGRAIDCTVHRIQFTPDLLPSDITGVSVYDQEKREFVFKPGGIFANIVVGDEINRTSPKTQSALLEAMGERQVSADGLTHPLEAPFMVMATQNPIEMEGTYRLPEAQRDRFMARITMGYPTRSAELAMLEHHGATSPLDEVRPVTDTQTIRRLISTVLGVHVAVDIHEYVLDIIGATRSHESIRLGASPAQPSTWSVRAELARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP3</accession>
    <name>W4TKP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69515">
        <property type="protein sequence ID" value="GAE69515"/>
        <property type="gene ID" value="JCM18909_2740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030077">
        <property type="term" value="C:plasma membrane light-harvesting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045156">
        <property type="term" value="F:electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014747">
        <property type="entry name" value="Bac_photo_RC_H_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="320" mass="35150" checksum="F7C0DCCF50C86ABB" modified="2014-03-19" version="1">MDISAMDPKDILGLFDAEVVGPDGEKVGTIQQIFADEVTGAATFVTVLSQGHEYFIPVRGAEYSTSQVNVPFSRNLIETAPEASEEDDLSRDREAEVYGHYGMEPARRPGLEISDDDDIAIAHPGRGAVSESDIVEADVVDDSEPDSAEPDADEAGQDTVVTPIVVPGPGSDAEDTDEDEENRPKVLSDDHGDEEARTVDSAPAVGLPAGAKLRRYVVTDLVTVQIPVRREVVCWEDSEGNIHDFDKVEAPEEAKRLGFRVKRPGGSTTARRLRLVDALEIVKRASASDPPRIGGRRCRNLLRWYSVRRPSHRSRRQRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP9</accession>
    <name>W4TKP9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68734">
        <property type="protein sequence ID" value="GAE68734"/>
        <property type="gene ID" value="JCM18909_1888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7654" checksum="A7038EB27FA0C91D" modified="2014-03-19" version="1">MPTLMVVGGVIAGVVVSLLCQAGVRAGARAAARYARSELRANLTDVTWQSVVDPVNAELDHHDEVVKIVAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT6</accession>
    <name>W4TKT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69391">
        <property type="protein sequence ID" value="GAE69391"/>
        <property type="gene ID" value="JCM18909_2600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18353" checksum="D98EBDA8040F4A0B" modified="2014-03-19" version="1">MSDMDSQPSSRSSTVRDWVGLAARIILGATLLVAGIIKATDIDSTIWSVRTYQIVPWDLAPVIGWTMPILEIIVGLMLIFGIATRWSGLLGTLAMVVFIVGISSVWARHISLDCGCFGNGGPVDRNWDLTQRTYLLDILRDLGLTLCGVWLVIRPRSALSVDHWITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL16</accession>
    <name>W4TL16_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68859">
        <property type="protein sequence ID" value="GAE68859"/>
        <property type="gene ID" value="JCM18909_2026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="8986" checksum="2A84591798D806E6" modified="2014-03-19" version="1">MAFGSFDNQITRRGYVTKQMDQIWSERSTVQSWFDVEAALARVQSAIGMIPAGTGAQITGQAKATNTVSMTTSASGSTTEPPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL20</accession>
    <name>W4TL20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69416">
        <property type="protein sequence ID" value="GAE69416"/>
        <property type="gene ID" value="JCM18909_2626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11455" checksum="33D0D6DAD1D1108A" modified="2014-03-19" version="1">MSVVTTLSALKENSPQEFEVDGIDVVLVRTDGEVFAVGATCTHAEVPMVDGEVVDCGLECYMHGSFFDLRTGEPRSLPATEPLPVYPVTIDGDNVLVDVANPITKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE3</accession>
    <name>W4TLE3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69258">
        <property type="protein sequence ID" value="GAE69258"/>
        <property type="gene ID" value="JCM18909_2454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19166" checksum="9BAD77EB99903171" modified="2014-03-19" version="1">MASVKPTKDRGRYTNDLSAVTRQAANMLLLRPLVWKVVKVSVHGADNLDGLDGAYVAVANHSSHLDAPLVFGALPKRLSKYLATGAAADYFFTAWWKAIAPVLFFNAFPVDRGKGKSKQGARSPRSHRGMAGSLLTDGVPLLIFPEAPGLAPAQWAPSNPGLPHWLFHVGFRLSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR2</accession>
    <name>W4TLR2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding protein Era</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69442">
        <property type="protein sequence ID" value="GAE69442"/>
        <property type="gene ID" value="JCM18909_2657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="3">
        <location>
            <begin position="120"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="216" mass="23760" checksum="72ECB6359562AE8B" modified="2014-03-19" version="1">MCLPSNQRIGPGDTYLVSQIAELPRRPTLIALATKSDLVSKARMAEHLATIDKLQGEVGIEFVEIVPCSAVSGEQVDEARDVIASLLPEGPAYYPDGEVTDEPTETLVAELIREAALEGVREELPHSLAVEIVEMGPREGQPEDRPLLDVYASLIVERDSQKGIMIGHHGSHIKQVRTHARRQIAALLGTPIHLDLQVKVLPNWQSDPKYLNRLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT6</accession>
    <name>W4TLT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69154">
        <property type="protein sequence ID" value="GAE69154"/>
        <property type="gene ID" value="JCM18909_2343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="248" mass="27403" checksum="2798510851A0F346" modified="2014-03-19" version="1">MSTQRVIAHRGLSSRAPENTMSAFRAAVEAGIKWIETDVDIIGDGTAVLIHDSSLDRTTNCRGRYNELTASDLPAIDAGRWFSPQFIGEPLPRLADLVDFMNETGVNANIEIKSNEEGARSSLQLRDSVIAELERLEPGRQVIVSSFNHVLLSKFKEAAPQWDVACLYETAALYDDWRSMLELVGATYIHPEDSALTERSVAQFKEAGFRVNAWTINRADRANQLFNWGVDGVISDIPDLLVGSVAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW4</accession>
    <name>W4TLW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69741">
        <property type="protein sequence ID" value="GAE69741"/>
        <property type="gene ID" value="JCM18909_2990"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16353" checksum="52319E686EE13E8C" modified="2014-03-19" version="1">MIILGVGQAGFDLVLTALVGGHPDAQTSTILLLASFAGVWLVLWAWMRFVEQRPMSCLGFRGPGSDVWIGVAIAIAILAIDVVVMTVSGQVTMSWARPSTMAAVFIVAAILLFLVQGCAEEVVLRGYLMQSVAAKWGIPAGLAIQAVVFCCASWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW7</accession>
    <name>W4TLW7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="proac-q6a5t3">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69512">
        <property type="protein sequence ID" value="GAE69512"/>
        <property type="gene ID" value="JCM18909_2737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="49"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19623" checksum="6539779214D2EBC1" modified="2014-03-19" version="1">MTWNRNIPGLLTDDVRLRVPLNRSNPDDLRTIEVYARVVATPNGTHKPYLVFLQGGPGCESPRPTLRDPGFPGWLSRALEDYQLVLLDQRGTGLSSPVSEPVGDVPSQAEYLTHLRADEIVEDCEDIRRHLGIQKWAALGQSFGGFTLLRYLSTYPESLSAGYFTGGLPAVGRSADDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM47</accession>
    <name>W4TM47_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69473">
        <property type="protein sequence ID" value="GAE69473"/>
        <property type="gene ID" value="JCM18909_2692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10172" checksum="03B0CAAF7EF02715" modified="2014-03-19" version="1">MLRPTARRIPGRHDHAEYRSFIAWGLLTALFIETGWAPNATLAKLVNPTLTYLLPVLIGYTGGKIVNGTRGGVIGAIATMGVIVAPTSPCSLARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM50</accession>
    <name>W4TM50_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69811">
        <property type="protein sequence ID" value="GAE69811"/>
        <property type="gene ID" value="JCM18909_3066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19751" checksum="2A9E0F07491164AA" modified="2014-03-19" version="1">MRRMLFAVTKFKRVMALLGVIYLVTVGGLYFVLADRSDNFIHDGQIIQGTVTAVYSHRSVSTGATKYLMHAEGGNVALISYTYDGVTDTVWSNPYRDIKKYHVGQKVDLVIRATPNHPDDAIATVRDHTILGLRLIPWGFLASAVIMTAWFGRDYLRSKRRRRLGGQRHTPAAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM77</accession>
    <name>W4TM77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70085">
        <property type="protein sequence ID" value="GAE70085"/>
        <property type="gene ID" value="JCM18909_3373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5959" checksum="BF2D819718F9D9B9" modified="2014-03-19" version="1">MQVDKVVTHDVGIPASPDSHDYGAGAACCREAGRRVLHDQRWGCATPQERAPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB3</accession>
    <name>W4TMB3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69861">
        <property type="protein sequence ID" value="GAE69861"/>
        <property type="gene ID" value="JCM18909_3123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="4737" checksum="C6396C5D6F9423D5" modified="2014-03-19" version="1">MIKRDAGIKDMSNFLPGHGGVMDRLDSVLFSAPFAWLVMSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC2</accession>
    <name>W4TMC2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69339">
        <property type="protein sequence ID" value="GAE69339"/>
        <property type="gene ID" value="JCM18909_2544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027580">
        <property type="entry name" value="EXLDI"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04342">
        <property type="entry name" value="EXLDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="166" mass="19358" checksum="101F29D4C7190920" modified="2014-03-19" version="1">MYVSDEDQSLFQEAAELAGGFSPAVSEALREYVKRRKLMRGGAEQVEVDLRTDGIDHRVSFMGRRLVKVQRDHEQGCRIDTVYATARKQFAVVSKVRRVLPSWAEGKEDLWSHPETWDKEFWTVGDRTLKVFLRIWMSCERPMVNLQNGSTQRCTSHPTRFWTFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK7</accession>
    <name>W4TMK7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70225">
        <property type="protein sequence ID" value="GAE70225"/>
        <property type="gene ID" value="JCM18909_3523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_2d" evidence="2">
        <location>
            <begin position="12"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="136" mass="15194" checksum="0705A9F416004DCC" modified="2014-03-19" version="1">MRRQGHYHGTPQGTVDAFARAMFGDVRTRFRPHYFPFTEPSAEVDLECFVCHGASVGNPDRPCRICRSEGWIEWGGCGVVNPRVLVACGIDTDVYSGFAFGMGIDRTVMFRNNAPDLRDFVEGDVRFSRSLRGGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML8</accession>
    <name>W4TML8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70235">
        <property type="protein sequence ID" value="GAE70235"/>
        <property type="gene ID" value="JCM18909_3533"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="8">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13126" checksum="C623B0487F42CFB6" modified="2014-03-19" version="1">MLFRGAASSLLTEAGYRQCTDRKDLTLVDEANGVEFFYLRPRDIAVYVGEGALDIGITGRDLLLDSKADATEIKGLGFGHSRFRFAAPKGPKKHYRRVGGKADRYLLPRPVECFSGGAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT1</accession>
    <name>W4TMT1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S54.029"/>
    <dbReference type="EnsemblBacteria" id="GAE69489">
        <property type="protein sequence ID" value="GAE69489"/>
        <property type="gene ID" value="JCM18909_2709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="35"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="174" mass="18881" checksum="57BCBFD09797C020" modified="2014-03-19" version="1">MMAVVVAIMWILEVIDTMLGNTLDHFGIHSWTGQGLWEIFTAPWLHYGWAHLAGNSVPLFVLGMLVYLESTRTWIVSGLTIMVCSGLFAWCFSAPGTITLGASGIVFGWLAYLLVRGLFTKRLHDILIAIIVFLIYGSVLWGVLPGAAGVSWQAHLGGAVGGVISASRLARHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW8</accession>
    <name>W4TMW8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobalt-precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70320">
        <property type="protein sequence ID" value="GAE70320"/>
        <property type="gene ID" value="JCM18909_3634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9256" checksum="B45B4FC6D3073915" modified="2014-03-19" version="1">MFRCDLAHLSKTMRNHKLWKHAVVLVGPALAEGPISTRSHLYHPGFRHEYRAADAQAHADLKAHGTCGVYHRNSTNPDTKGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN30</accession>
    <name>W4TN30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70136">
        <property type="protein sequence ID" value="GAE70136"/>
        <property type="gene ID" value="JCM18909_3432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16774" checksum="5266BEEF406F54B2" modified="2014-03-19" version="1">MGVWTSLISLQPVSTSGSVSKITGRAISPLVPGFRRFSSLLPKPSSAVSTTPTRLSWPSAMRERRAMATRSPAADGPVAYRVALSATQLGIVARLVVPAVAARALGNDVDFPRSRTCGSVMCFLLRFPCRWLGNRDQRKSPVQRLKRSLVPSSPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN39</accession>
    <name>W4TN39_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oligopeptide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70390">
        <property type="protein sequence ID" value="GAE70390"/>
        <property type="gene ID" value="JCM18909_3708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20695" checksum="15BFC257C56802AD" modified="2014-03-19" version="1">MIELRDVTMIHRARGGKLFHPTLVRAMDHVNLSVHRGETLGIVGESGCGKSTTARVMVGLQKPTSGEVCFYGEPLGRHARDRKALGRAVSVVFQDPATALNPRLPIRQVLMDPLNVHNVGTRDEREARSVTYSAWLACPIRSLTCFPGRSRVASGSASPSPVPSRWIRTSSLLMSRPLPWMCRCVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN89</accession>
    <name>W4TN89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogen peroxide-inducible genes activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70410">
        <property type="protein sequence ID" value="GAE70410"/>
        <property type="gene ID" value="JCM18909_3728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="168" mass="18370" checksum="ABE112186A15F806" modified="2014-03-19" version="1">MNLHDLRYFVALAEEHHFGRAAASCGVSQPTLSTQIHRLENELGVVLAVRVGRRIEITPVGERIAQAARDMLVLSDDIRAMAREEADRMTLQLRVGVFPTLGPFVLPQVIARCDQHGPGVNIHIVEKRTAELLEAIRNGQLDVAAVAAPVNDDSLVTIPVFFGRSSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN93</accession>
    <name>W4TN93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lysophospholipase L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE69997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69997">
        <property type="protein sequence ID" value="GAE69997"/>
        <property type="gene ID" value="JCM18909_3275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849160" evidence="2">
        <location>
            <begin position="31"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="3">
        <location>
            <begin position="70"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="207" mass="22906" checksum="B1C8D371FBE57F1B" modified="2014-03-19" version="1">MTFTKKLSALAIAGTMAITGASMATVPAVATDKAPAPAAATVQSKLITGYTTSTDQWGTELFFRKNIVPNAKGAVVIVHGAAEHSGRYDYLAKRLNDAGYSTYRFDHRGHGRSARPYVDNAIPRGHIDDWSNLVNDVHQFVQIAHQENAGKKRSSSSGTPWVVSPFNPTALSTGNRCRHCEQRRWHRRQPMGPRHRRAEEGHRTRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNC2</accession>
    <name>W4TNC2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucoamylase S1/S2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69714">
        <property type="protein sequence ID" value="GAE69714"/>
        <property type="gene ID" value="JCM18909_2963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9637" checksum="FBA136EB4CFCF2C7" modified="2014-03-19" version="1">MEWGPNTVTLTMTIAVTKGSLTDYTFFIMENQSTDIHQASQPPTGSLGTGVSQGHKVHGTITIDCPRTDATVMLTHGSGMSSPISALMIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF0</accession>
    <name>W4TNF0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70266">
        <property type="protein sequence ID" value="GAE70266"/>
        <property type="gene ID" value="JCM18909_3570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8875" checksum="28B57DB04F4FC561" modified="2014-03-19" version="1">MTRTEFALLAVFLQNPEKVLERSWLLHEVWGFDFPTTANSLEVYIGYLRRKTEHDGEPRLIHTVRGVGYVLREANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI1</accession>
    <name>W4TNI1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69943">
        <property type="protein sequence ID" value="GAE69943"/>
        <property type="gene ID" value="JCM18909_3213"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="241" mass="26372" checksum="DAA0649C882219FC" modified="2014-03-19" version="1">MAPLDFDEKALPAPVRAELRGVPADTAHIIEGHLVAAAELLDEDPAQANAHAQAARRRAPRLPILREVAAEAAYQAGEYASALNDYRALRRMTGNDNFLPVIADCERALGRPQAALRLIREGQEAGLNPAQQIELVLVQAGARRDLGQRDEAVRLLREAVKLKAPTEATARLHYAYAETLLEGGDTAGARKWFVSAQRHDPANFLDSQDRIDIIDGREPSGDPADDMIFIEDDNEGEETDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI4</accession>
    <name>W4TNI4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70102">
        <property type="protein sequence ID" value="GAE70102"/>
        <property type="gene ID" value="JCM18909_3392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="363" mass="40251" checksum="E64E9BDE594CAE92" modified="2014-03-19" version="1">MFDADPHRAERYTFDVADLHVDLSKNLLTDEIRDALLELAAQTHVTERRDAMYAGEHINVTEDRSVLHTALRRPRTDELHVDGQDAVADVHEVLDKIYAFAGKVRSGEWKGVTGKPIRTVINVGIGGSDLGPVMAYEALKPYVKDGLECRFISNIDPTDAAVKTADLDPETTLVIIASKTFTTLETLTNARCVRAWLLDGLVAAGAIADTEQARRDAVAKHFVAVSTALDKVEEFGIDSECFWVLELGGWPLLGGFRRRYVACRRDRAEGFRGLPSRISRRRRALRHHRAGAERPAAYGHVEHLVRQLLEGPLACGASIFTVFAPLPGLFAAADYGVEWQVGALGWFSSNYRHRRDFLGRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNQ1</accession>
    <name>W4TNQ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70023">
        <property type="protein sequence ID" value="GAE70023"/>
        <property type="gene ID" value="JCM18909_3303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5802" checksum="30BD3A37004D42C6" modified="2014-03-19" version="1">MIGRSCVVFFWPLDFLSSCEHLGDDNVDAAAIDLLDCFEGQSQGDFSTNEGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT2</accession>
    <name>W4TNT2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70058">
        <property type="protein sequence ID" value="GAE70058"/>
        <property type="gene ID" value="JCM18909_3342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="5">
        <location>
            <begin position="119"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="261" mass="27139" checksum="24B94AD5E17A215E" modified="2014-03-19" version="1">MSTKKVRDGQALDNHQATAVAPAMTTTITAADYDACRSADVIIVSAGPSVLPDSYGGGHDSRNSLAQVNSKVIREVMGNICQYTHSAPIILITNPLDVNVHIAATEFDYPTNLVVGTGTALDSARLRRHLADWAGVSPDSVQAFMLGEHGATAFPYLSHASIGGLTLAEATTALGLQPLSPEQVGNSVVQSAFDVLEGKGWTSSGISKAAVSLARAMLLDQRSIHPVCTLADGVLGFHGEVSLSLPTVVGGHGVEHHLDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV6</accession>
    <name>W4TNV6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine esterase cutinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70088">
        <property type="protein sequence ID" value="GAE70088"/>
        <property type="gene ID" value="JCM18909_3378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17075" checksum="30F3F018305E154D" modified="2014-03-19" version="1">MRAIIEATLSLSQNSINQKALDADISKAGAAIPAEAYPETYSVCMKGDPVCDTAPALTRILTLQSTWQDELNQGRPIHMGYTRTVMEGALDRIAQRINAISAAEAKGTPLPHGSTVAVTTRDWGPLQIGVAVGAGVAGLGAGWLLGRAGRRRQRRRRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP03</accession>
    <name>W4TP03_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70272">
        <property type="protein sequence ID" value="GAE70272"/>
        <property type="gene ID" value="JCM18909_3576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15745" checksum="DFE6A4FAA6CEEDA7" modified="2014-03-19" version="1">MTVHSVLPFPLSGLPVTFIGYCIINGLGFLIDMSLLAVFFRGVGLPYPVSVSLGYGLSAVYSFVVNRWLNFHSHGNLGRQSGRYVVTMVTNYVCLTLGLSSLLESLGVHFELARFTAACVEGLYVYLMLSIWVFPKSGRRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP18</accession>
    <name>W4TP18_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-ribazole-5'-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70158">
        <property type="protein sequence ID" value="GAE70158"/>
        <property type="gene ID" value="JCM18909_3454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021403">
        <property type="entry name" value="DUF3043"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11241">
        <property type="entry name" value="DUF3043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11922" checksum="AF31462F61CB83BC" modified="2014-03-19" version="1">MDFQRIHYADLPAVMVIWLAMLFIAPTAVGAINAMSMGMLIVMILWLIDSWRLWHGAKKRVRARYPSAPLRGLWSYLNNRAMTVRRWRNPAPRVERGERIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP26</accession>
    <name>W4TP26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase component BioM of energizing module of biotin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69939">
        <property type="protein sequence ID" value="GAE69939"/>
        <property type="gene ID" value="JCM18909_3209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6245" checksum="08E1BDEC167C5734" modified="2014-03-19" version="1">MIEFTNVSVDVDEYDVEGRHRRVKILSTVNLIVPERRVAVIGPNGAGKSTFSNSLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP28</accession>
    <name>W4TP28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70168">
        <property type="protein sequence ID" value="GAE70168"/>
        <property type="gene ID" value="JCM18909_3465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="270" mass="28237" checksum="8919ECD718685375" modified="2014-03-19" version="1">MMIPCLLLTGAVQLTVMARIATSIRAQRQSMLKLGIPLSATLASALGSVLAICLAAWSAGVCGGWILGMALRRFLVPHLLTQPISPPVSIAPLAMTLLALTVAMSIAAIPLTGPRAGGRNRTTPHHARAATTLRWVRRVAGVLLIIGGLLALQNRTQLDDVMHGAIFVSSGAVLLMPDLISGIISVVKLPTPAGLLAVKTLHFNDARIRIMGSALCLCLVIPASVNVIMTSYQQSTAALSMAPPDTLILQSPDGNPVPKDLPRSVQARPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP58</accession>
    <name>W4TP58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin biosynthesis protein CbiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70317">
        <property type="protein sequence ID" value="GAE70317"/>
        <property type="gene ID" value="JCM18909_3631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TP_methylase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="216" mass="23791" checksum="8B0DD29CDE3F5F84" modified="2014-03-19" version="1">MCGGDPAIYAMASPTLEMGTDGIDVEIVPGVTAELAISAILGAPLGHDHATISLSDLHTDWDLILKRVKAAAEGDLVTTFYNPRSRTRTHQLPDALAIMAEHRPPSTPVALVSHAERRQQQVIMSTLEEFKPEWCGMTTLVVVGSTTTKYVSSGDGRRLMVTPRDYHWMDGHVCSEARKNYTHKDLPKADEETYLSKPPAYSTRMLEPTNDTKDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP62</accession>
    <name>W4TP62_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70198">
        <property type="protein sequence ID" value="GAE70198"/>
        <property type="gene ID" value="JCM18909_3496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6155" checksum="229D03FAE9CD0379" modified="2014-03-19" version="1">MPHTETFEAFSGQGVGSALARFALDDIACQDLSVRPDCTFIKGWLDKHPDHPVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP92</accession>
    <name>W4TP92_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplT</name>
        <name evidence="8" type="ORF">JCM18909_3526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70228">
        <property type="protein sequence ID" value="GAE70228"/>
        <property type="gene ID" value="JCM18909_3526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="13248" checksum="CF1F993C3C3FDF53" modified="2014-03-19" version="1">MNAKKKRREVLDQASGYRGQRSRLYRKAKEQTLHSATYSFRDRRAKKGDFRSLWIQRINAASRAQDMTYNRFINGLKNAGVEVDRKMLAELAVSDINAFNSLVEVAKANQPQNAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPA4</accession>
    <name>W4TPA4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70238">
        <property type="protein sequence ID" value="GAE70238"/>
        <property type="gene ID" value="JCM18909_3536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022292">
        <property type="entry name" value="CHP03843"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03843">
        <property type="entry name" value="TIGR03843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="232" mass="25433" checksum="50C2317751F2E49A" modified="2014-03-19" version="1">MRDADLRLWVYKPTARERRLHDFPSGTLARREVAACLLSQVMGIGLVPVTVLVGDGPQGPGSMQRWIDDDVESPLIRADVTEHLPPHWHGFLLGVDEDDREIGLAHSPHPALRALALFDAVVNSADRKGGHVLVGPDPDLGGTAHVWAVDNGLTFHTDPKLRTVLWGWAGQPLEPVEEIMLDEVLTIADTDFEDLITPEEIDAVRQRAQGLLEFGAFPGPSGLRPALPWPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPB8</accession>
    <name>W4TPB8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70253">
        <property type="protein sequence ID" value="GAE70253"/>
        <property type="gene ID" value="JCM18909_3556"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="190" mass="21975" checksum="BFA442CAB6836152" modified="2014-03-19" version="1">MAFIKRMTEQTLDITTVEGKQDFVRNLIAYNIILEGIWFYSGFMVALSFRQRNLLRNFGSLIDWVVRDESLHLKFGVNLILTVLEENPEIATDEFAAEIHDMIVQGVEMEEQYNRDMLPRGILGMNADYVNDYVKYLADRRLEELGFEPEYRVANPAKWMATANDTLQVVNFFEATNTSYEVNAHATGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPC0</accession>
    <name>W4TPC0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70566">
        <property type="protein sequence ID" value="GAE70566"/>
        <property type="gene ID" value="JCM18909_3911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16897" checksum="09CB995311388595" modified="2014-03-19" version="1">MPPAASVPLDLYPPVSHDPRWWWLVAGCLLAAVAAMWGCRRVLAAIDSAAAGDGPVTLETVRAAALQDLEEAKDVSERGESDRAVCRRISIALRRFVGIVCDNDLDYEGLDDLSRAPMRMRGSNPSLRLSSAATRWSSTQVATTSIRTNWCRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPC8</accession>
    <name>W4TPC8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isopentenyl-diphosphate delta-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70263">
        <property type="protein sequence ID" value="GAE70263"/>
        <property type="gene ID" value="JCM18909_3567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="15428" checksum="6D02D278B8A43404" modified="2014-03-19" version="1">MTRRALTKVAWPGVWTNTCCGHPRVGETIIDAAVRRTHQELGLDLDPRRMRIVLPDFSYRATDSGGIVEDEFCPVVVARLSLPEELVELNPDPDEVEEVAWVGWQDMYGLARSMPALLSPWAVEQMLEFGPDLPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPC9</accession>
    <name>W4TPC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70059">
        <property type="protein sequence ID" value="GAE70059"/>
        <property type="gene ID" value="JCM18909_3343"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4255" checksum="DF476EB1675757E0" modified="2014-03-19" version="1">MSIAPHLVIIGIGHVGSDAVTNAAALGLFSRISLIDVDKKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPN5</accession>
    <name>W4TPN5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Error-prone repair homolog of DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000071">
        <property type="protein sequence ID" value="GAE70701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70701">
        <property type="protein sequence ID" value="GAE70701"/>
        <property type="gene ID" value="JCM18909_4081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6140" checksum="6F60FA6C51F1C11A" modified="2014-03-19" version="1">MTFLNLGDETGLLNVIVTPGAWRHYRRVARTSRALVVRGILEKGDEGVMSLQADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPR6</accession>
    <name>W4TPR6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70398">
        <property type="protein sequence ID" value="GAE70398"/>
        <property type="gene ID" value="JCM18909_3716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19477" checksum="709A1EFD8ECFFD3E" modified="2014-03-19" version="1">MINGMSDTNDAVHLADNLNPAAERMFKWILSSDLAPGDPIPIEQDLATQFGMARGTVREAVRELRALGILEVRRGLGTYLSTASASTIRPSLVYRSVKQITSDESGTRDFIGLREMVEVRALWSAHWSPKSPAASAPRPDGPCTPWRPGWTTLRTPPLRTASSTDCCTRTWAINSPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPV7</accession>
    <name>W4TPV7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70567">
        <property type="protein sequence ID" value="GAE70567"/>
        <property type="gene ID" value="JCM18909_3912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29968" checksum="C52642BFE23D6183" modified="2014-03-19" version="1">MELMWWWMWPAVVAAVAVTVVIGLLLRRREKIVRVVVAHVDRLRALPAYRDHARRRVRCLVIAAVCWGVAACGAGLVAARLQGIDDDDRQIRTRDVMLCLDVSGSMEGVDRQVINTYIQLADHISDDRIGFVMFDSSAVTVFPLTHDRDSVKAGLKQAGERLGRADLDPAVRYGPGGSLVGDGLASCVSRFDQLDQPRSRSIVLATDNMVAGPSVYTVPQAVDLAVKRHIMVFWHRARQRRSRLPGGSRRAAPAGATHPRRDLDDTFERAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ78</accession>
    <name>W4TQ78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000068">
        <property type="protein sequence ID" value="GAE70697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70697">
        <property type="protein sequence ID" value="GAE70697"/>
        <property type="gene ID" value="JCM18909_4077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="3"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="349" mass="36188" checksum="B1F2C377F51CEA3E" modified="2014-03-19" version="1">MAAIAVLGTLDTEGDELDWLRHRILTNGGKVVIIDVGSFSNSRIADYTSDEVIRAAGESPSDIRTRYNRGEMMDVMGRGASVIASRLAEEGRIHGLLSLGGSGGSSVAASVMQALPIGFPKLLVSTMASGDVSPYVGQADVTLMYSVVDVAGINSVSRMVFANAAAAIAAMAKGYEDAGIVSNTAHNKPVIGLTMTGLTTPAADEARRTLTDLGYEVLVFHATGSGGKAMEKLASSGLLAGICDLTTTELADDLCGGVLSAGPRRMEAAADLGIPEVISLGALDMVNFGPVDTVPERYSSRTLHIHNPAVTLMRTSDTEMAELGHRIAIKAAAARGPTQVFIPTLGSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE48</accession>
    <name>W4TE48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase electron transfer subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_86</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67051">
        <property type="protein sequence ID" value="GAE67051"/>
        <property type="gene ID" value="JCM18909_86"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27013" checksum="92B4A5ED1D3EB38B" modified="2014-03-19" version="1">MRLVDRHEIAAGIYSVRLIPHEPVPHVVPGTFLDLLLGGGHVLRRPLSIADADDEGYTLIFRVVGKGTDTLSVKPIGAEVDVLGPLGHGFDVDAVQPGGRALLIGGGVGIPPLYLSGRRLVERGVEVQFRLGFRDRNDIFWADRFGQLGEVLVSTDDGSVGTKGTVAQIAETDEARRFVPDLVQACGPLPMLRWVKSVLAPTVRTQLSLEERMACGVGACYACVVGDARDLDHQFRVCFDGPVLAAEEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE62</accession>
    <name>W4TE62_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67255">
        <property type="protein sequence ID" value="GAE67255"/>
        <property type="gene ID" value="JCM18909_300"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IGPS" evidence="6">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8383" checksum="0BD999432005F9F5" modified="2014-03-19" version="1">MNARNLKTLEVDKTIFRELLGELPENVVKVAESGILCVDEAVEVYDLGADAVLVGEMLVRHGEPAQVLRKIHRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEP2</accession>
    <name>W4TEP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67415">
        <property type="protein sequence ID" value="GAE67415"/>
        <property type="gene ID" value="JCM18909_474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="8873" checksum="C4778AD54E3D9D32" modified="2014-03-19" version="1">MKAFKESGADIADLCSNAKTYAAQGLEVAKALKEAGAKLVYLSGAFKEFGDDAAEAEKVIDGRIYLGMDVVDVLTATLDTLGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEP5</accession>
    <name>W4TEP5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67266">
        <property type="protein sequence ID" value="GAE67266"/>
        <property type="gene ID" value="JCM18909_312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13183" checksum="F971B1B2E3BBA712" modified="2014-03-19" version="1">MADLHGFMNVPRQEAERRPVEERVQDWKEVYPGGPGHALLPIITDQASRCMDCGVPFCHTGCPLGNLILDWNDLIWRDEWREALSCLQTTNNFPEFTGRLCPAPCETACVEGLTAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEP7</accession>
    <name>W4TEP7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_26</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66997">
        <property type="protein sequence ID" value="GAE66997"/>
        <property type="gene ID" value="JCM18909_26"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE66997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23647" checksum="DDCC55B3AEDEFEAE" modified="2014-03-19" version="1">MLSAHALNQGQVIRPEAINSLIAETVGFVRETLPPKHPYAKVVVTPAGHIQPQTWLLGSSGQSAAWAGEQGMDYAYAQFFFTGRQDTGNMDHYRAHLSDGFPGRTLSAVCVSAAPTRQEALEQSLMAANFRVSLGTGRPVTFVTASQMDAETRSLLTSYVLSNEDTILVGDYDEVADKLTAFQDAHHVDELMLISYIDNVQTKVEQYRQLAKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TET3</accession>
    <name>W4TET3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67460">
        <property type="protein sequence ID" value="GAE67460"/>
        <property type="gene ID" value="JCM18909_522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5432" checksum="840D0058C703E55A" modified="2014-03-19" version="1">MNTQQSAVSDGGWSVRARLTEVSPAATSADAGDPAVSSVSDPCGFDEFCGMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEY2</accession>
    <name>W4TEY2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate-ammonia-ligase adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67515">
        <property type="protein sequence ID" value="GAE67515"/>
        <property type="gene ID" value="JCM18909_579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="1">
        <location>
            <begin position="110"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="447" mass="49141" checksum="00A998E215933BFC" modified="2014-03-19" version="1">MARFFYSPVVEAVARIPTQDLRMSAEAAKVRLSALGFHDEDAGLRHIEALTSGTSRAVRIQSALMPAMLAWLADGPSPDHGLLAFRQVSEALGESPWYLRALRDEGAMAQRLAVVLSTSRYAVDVLTRAPETVQVLVDDDLTPLSREDLARQMNAVARRHHDVEEAVGAIRAVRRRELFRILVADILNVTGIRRIGQALTDLTGATIDAALTAVSREVEDAPPIGIVAMGRWGGQELSYASDADCLFVVGDGPGVGGKALKIVTKLRNLLGKHGADPAVVLDADLRPEGRSGPMVRSLESYRKYYGKWSSTWESQALLRASHGAGDRELTTELLECVDQVRYPADGLTGSQLAEIRKLKARMESERIPRGVDPRRHLKLGPGGLSDIEWTARSFSCSMPAMTQLYAPPRRLTPSTLPWRLVTLTRISTPNCATHGWRRVDCVTRSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF11</accession>
    <name>W4TF11_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/lipase/thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67112">
        <property type="protein sequence ID" value="GAE67112"/>
        <property type="gene ID" value="JCM18909_151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="121"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="350" mass="37324" checksum="DDEC8027FFEB05F5" modified="2014-03-19" version="1">MVNRCRPALAQHIHVRLLRARGLARRADLVIATTAFILGFLGRGALRAVTVVVSAAALVVPVATTATTTWITDRAGGHINVPLATAVTSMSDLPDATIRYGSGADETAQLYRPKNRHARVLVDIHGGGWNTDATMPATLRWFADHGWLVIRPSYTLATQGHPTWNTAPKQVACAWAWSLSHVKELGGDPSQVSIMGDSAGGGMAINLAYGAASGKLTSPCGSMRAPKSVLALYPTVDVGTVESITTLSAGNAAKMYIGGTPKQFPDRYRAVNSSTWITPQAPPTMVIQGNHDTFVPPSSVRKFVDRARQTGVGLDHVQLPMLNHAFDSQARNSLGFQVVTSLGQRFLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF36</accession>
    <name>W4TF36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67137">
        <property type="protein sequence ID" value="GAE67137"/>
        <property type="gene ID" value="JCM18909_177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="12893" checksum="88660C5A9D16C2B5" modified="2014-03-19" version="1">MADVVVPIVAVPEAMPRYAMPGDAGADLTCRHDVDLAPGERAMVETGVRVALPDGYVGFVNPRSGLAARHGLSIVNAPGTIDSGYRGQINVLLVNTDPREPVHLDAGSRIAQLVVVPVVEAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFC3</accession>
    <name>W4TFC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67133">
        <property type="protein sequence ID" value="GAE67133"/>
        <property type="gene ID" value="JCM18909_173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025242">
        <property type="entry name" value="DUF4193"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13834">
        <property type="entry name" value="DUF4193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10920" checksum="6807AB60CC9BC493" modified="2014-03-19" version="1">MATDYDAPRKTDEEVSEDSIEELKNQRNDKNSGKVDEDEVEAAEAFELPGADLSHEELTVRVLPRQSGEFTCASCFLVKGRSQLAGERDGQFYCVDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFG1</accession>
    <name>W4TFG1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67705">
        <property type="protein sequence ID" value="GAE67705"/>
        <property type="gene ID" value="JCM18909_784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="14364" checksum="79F6E7DA5E8711EA" modified="2014-03-19" version="1">MIILVTGMSPHVAILIAAQMGFLTAAVVITAVGHRVAGPTAAVLLVACWGAAPRAVVESMGYTEGWFIALVGLGLLAILSGRWILAGTFVGVAGLFRASVAPVCIVLGIAWLTSLCTKAAAGQRWRRFIGMALSRWDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFH1</accession>
    <name>W4TFH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67715">
        <property type="protein sequence ID" value="GAE67715"/>
        <property type="gene ID" value="JCM18909_794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14289" checksum="2DBBDD3200F562A9" modified="2014-03-19" version="1">MSPASRFPRPTTSDITKTGIELPAEASEALDKELEFEQVESREARTHRLSTGVLIGIMALVLFILLTTTSGEAHFAFTDALAGKELGTMSVSGFPVVLVSAIACLLAVGAFFMGRSVTLSRLLLVSSPESPSSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFH9</accession>
    <name>W4TFH9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67521">
        <property type="protein sequence ID" value="GAE67521"/>
        <property type="gene ID" value="JCM18909_586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025326">
        <property type="entry name" value="DUF4232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14016">
        <property type="entry name" value="DUF4232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850700" evidence="1">
        <location>
            <begin position="26"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="22321" checksum="6EF638973FAB0382" modified="2014-03-19" version="1">MKMGRVVAVVAAVAAIAGCSRTTPAVPEAVVPTSSVMSTPKYSPRPQTSTTPQRMISATAQRVTSVGGAQGALTCRRGEKAAMAFSDVDAALGARITMLTIRNCGSSVMTLPVMPQLRQTTEAGVRVPVAWQPYDSKARTKRLAPGKVASWELSWHSNGDCEHRGAWRLEAQVGATTAMLVGCLDLGSFYALTGESSTGPVAPTPFQCRKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFJ7</accession>
    <name>W4TFJ7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cellulase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67745">
        <property type="protein sequence ID" value="GAE67745"/>
        <property type="gene ID" value="JCM18909_826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="269" mass="29707" checksum="AA005B906F8FED46" modified="2014-03-19" version="1">MPRAPPYAPDAVGFGEDDAAFLEAQGFTSVRLGVLWAGVEPRPGVYDDAYLARIERTVRILNAHGIASVLDFHQDMVNEKYQGEGWPAWAALDHGMPNIVKTGFPGNYFLNEAVKYSFDSFYDNTKASDGIGVADHYASAWRHVAEHFRNVPGVQGYDLFNEPFPGHRYTRCLTQLGCRAADARLSAVQQKTVDAIRSVDKATTVWYEPMQFFNIGVGTNVRLTGSNLGLSFHDYCTSQATLHSYVGCTAPDNRVFTNAEKHSRQTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFN0</accession>
    <name>W4TFN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane component BL0694 of energizing module of predicted ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67780">
        <property type="protein sequence ID" value="GAE67780"/>
        <property type="gene ID" value="JCM18909_863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7398" checksum="BFCB7C35AFDE0471" modified="2014-03-19" version="1">MKHDEATLALPGATHRVPHSRSVAGIGFDTASAVHTRRSRQLFGTVDPRTLALYVIVLNVLLMGAGSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFU5</accession>
    <name>W4TFU5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67651">
        <property type="protein sequence ID" value="GAE67651"/>
        <property type="gene ID" value="JCM18909_725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10399" checksum="EBE516652CE49CF0" modified="2014-03-19" version="1">MYDIGRSKRATRAYSLDDIALIPSRRTRGTEMVNLEWRIDALTFDFPIMAAPMDSVMSLRRLLSLGVWAVLVCSTLRVCGPVTRIPPRTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW2</accession>
    <name>W4TFW2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67671">
        <property type="protein sequence ID" value="GAE67671"/>
        <property type="gene ID" value="JCM18909_747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="381" mass="41905" checksum="C8E1E231D000F968" modified="2014-03-19" version="1">MRFYERKEVRDAVSYLRAIANPSDDVSLRRILNTPRRGIGARAEAAVEMFATARRISFWEALKRIDEIDSLATRSVNQIRVFVSLMDDHIAMVEQGKRADEIASSILKESGYITELENSKDPQDETRLENLVELVSVAQEFVARVHAVDIDEAEQGNVEDLELSGDDSLPAFLEQIALVADSDQVPADSDGVVTLMTLHTAKGLEFDTVFITGFEDGVFPHMRSLADATELSEERRLAYVGITRARKQLFVSRASVRTMWGQAQYNPPSRFIDEIPERLIEWERIGQASVGWSTSASGRSQSARGALRDDTPAFGSGRGSARALKGRTLALSVGDKVLHSTFGLGTVKATSGQGDNAKADVDFGSAGLKRLALRFAPLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW9</accession>
    <name>W4TFW9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67333">
        <property type="protein sequence ID" value="GAE67333"/>
        <property type="gene ID" value="JCM18909_380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7806" checksum="AC6A00B7A1D4AE2B" modified="2014-03-19" version="1">MTITFKPLWKLLIDRDITREELRRQTGLSPAIIAKHRRDGNVTTDVLARICKALNCNIADICEAVPTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX7</accession>
    <name>W4TFX7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endo-beta-N-acetylglucosaminidase H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_73</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67039">
        <property type="protein sequence ID" value="GAE67039"/>
        <property type="gene ID" value="JCM18909_73"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4742" checksum="8BB61D735CD7C7A8" modified="2014-03-19" version="1">MTTAVYIEVNHEDLATVGAFVREGVHRPVFDLAMIFCGQYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG09</accession>
    <name>W4TG09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein YceG like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67368">
        <property type="protein sequence ID" value="GAE67368"/>
        <property type="gene ID" value="JCM18909_418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6247" checksum="491E3F00F26FE6DD" modified="2014-03-19" version="1">MTPIKSDYLYWVVTDPDKGTTAYSKTLAEHKKKMSRNSKLGVRTQGEVLGQYVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG31</accession>
    <name>W4TG31_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67746">
        <property type="protein sequence ID" value="GAE67746"/>
        <property type="gene ID" value="JCM18909_827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850710" evidence="1">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8835" checksum="BFA35F041554D6B2" modified="2014-03-19" version="1">MRRKSALGFVALSLFATGMGVAAATPATASPADTAAPVRVDASRWTTQGRWVTDAQHRVVITQGINEVAKSAPLRPRCRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG90</accession>
    <name>W4TG90_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67970">
        <property type="protein sequence ID" value="GAE67970"/>
        <property type="gene ID" value="JCM18909_1072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13614" checksum="F242F46946EAB92C" modified="2014-03-19" version="1">MFERFTDRARRVVVLAQDEAKALNHNYIGTEHLLLGLISEGEGVAAKALESLDISLEAVRAQVEEIIGHGTSTPTGHIPFTPRAKKVLELSLREALQMNHSYIGTEHILLGLIREGEASLLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA9</accession>
    <name>W4TGA9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67990">
        <property type="protein sequence ID" value="GAE67990"/>
        <property type="gene ID" value="JCM18909_1094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12601" checksum="A0FA3EE3177CA4A5" modified="2014-03-19" version="1">MFIDANRFDLLEELILAEPLGHGQPVVLIDGRSGAGKTTVTNTLICHHADWQLVHADDLYPGWSGLSAVWDLRDLVARRRYRRWDWYQNRFDDEVILDANRPLVIEAAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB2</accession>
    <name>W4TGB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67572">
        <property type="protein sequence ID" value="GAE67572"/>
        <property type="gene ID" value="JCM18909_643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="416" mass="44866" checksum="EC215397B21850F9" modified="2014-03-19" version="1">MVAQILKHQWVTTLVPLRKGAKLAEIFGFIFLVLVSLFLGGNCFAYVRAAGQLAIDPRGASTAVAGASLIVFWITVPVLFGAQPTYTDPSRYAVFSRRARELMPAFVVVGLLSWGGVVTLVASVSHVLAWSSAGAVAMVAAVLGVLLGWSAAMIASNLLLVAMSAVMAKRRFRETMMILVMLLCCGLGLGMQVVTRTATVTRTVPVNVGRTIGWTPLGWAWSMPWEVAHGRWLAFAIKLVVSIATVAVMVWAWQVIVARRLVAPTGDGGSVEKVKAANGIDRMMPDTPTGAITGRTLRYLKRDPRMTSLLLNTFLVPLLASARCSSMVGARCTVRRWLSSSPRSPSPRCSLRRRCMPGRSSATTERLCGTTLSHRLRGWRIAAVARLRISSSPCRSAWRWPSSPPGGVVSGSCCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB8</accession>
    <name>W4TGB8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="3">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_514</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67453">
        <property type="protein sequence ID" value="GAE67453"/>
        <property type="gene ID" value="JCM18909_514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB_4TM" evidence="11">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11187" checksum="9F9363CF502F4307" modified="2014-03-19" version="1">MLSIALIALLTFSPMEFVALFGTFAIAVVVGYYVVWNVTHALHTPLMSVTNAISGIIIVGAITQLGSESWGIRIVAALTVLIASINIFGGFTVTQRMLKMFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE9</accession>
    <name>W4TGE9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional NAD(P)H-hydrate repair enzyme Nnr</fullName>
            <ecNumber evidence="9">4.2.1.136</ecNumber>
            <ecNumber evidence="8">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="9"/>
    <dbReference type="EC" id="5.1.99.6" evidence="8"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67607">
        <property type="protein sequence ID" value="GAE67607"/>
        <property type="gene ID" value="JCM18909_680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00018591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE67607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="23567" checksum="94DE82B0EE2CE0BB" modified="2014-03-19" version="1">MESCVHAAYTITFSSLKWCHIAHPAARYCGELEVHDIGLDFIDDDGECLDDVDEYCDLAEMASLWPVPGALDDKYSRGVVGIDTGSEKFPGAAVLGVLGALRTGPGMVRFSGPSAIMTFILSRAPSVVIGEGRVQSWVIGSGWGTHDGNADRFIQRAAEGVPMVIDADALALLPAELPEGCLLTPHAGELARMLRIERSQVVADPRGSAVRAAQRFARPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG5</accession>
    <name>W4TGG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-S18p-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67622">
        <property type="protein sequence ID" value="GAE67622"/>
        <property type="gene ID" value="JCM18909_695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16335" checksum="FE0DAE15EAC0F255" modified="2014-03-19" version="1">MSDLDAIMAIEQASFDPLWSRTSWAEEIAPADHRLTLVAGDDEVAAAATFHGFNVADLDRIMVTPAARGRGLAVELLARGLDWATSRGCHTMMLEVRRDNSPAIGLYRRFGFETISQRPNYYGGGIDALVMSVDLPRAETTTPSEENHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ9</accession>
    <name>W4TGJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67279">
        <property type="protein sequence ID" value="GAE67279"/>
        <property type="gene ID" value="JCM18909_325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17232" checksum="ED14CA94BDF4EDA8" modified="2014-03-19" version="1">MDYHLLAREILDLVGGSDNIESFTNCMTRLRLNLIRPQTADAEAINGLAGVLGIVEGKQLQVVVGPGHAERLRSAFGEVMGSADSAPATDIDATAQVTPPGTAKRGADSAVVETEPSPVLEGDTDIAVRTKKMVRGTQTSRVQAMFRHVGNIFVPIIPGSSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN5</accession>
    <name>W4TGN5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68130">
        <property type="protein sequence ID" value="GAE68130"/>
        <property type="gene ID" value="JCM18909_1247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11282" checksum="60472CE930AD8EC3" modified="2014-03-19" version="1">MIVYLAALGNVDHDLHEAAALDGAGTFQRFRNVTIPGIRPAMVLIIALIAVSGMRIFSELYVLTNGTGGPGGEDSSLVMVIKQVGTGLSGQLGYASASQLCCSSSPSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU9</accession>
    <name>W4TGU9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67374">
        <property type="protein sequence ID" value="GAE67374"/>
        <property type="gene ID" value="JCM18909_424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="5431" checksum="E674B29887D0F843" modified="2014-03-19" version="1">MDKKTRVDPQTGRQVLRFVGIHKPGQVAMIVDPDEAALAECYDRCSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGV1</accession>
    <name>W4TGV1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67653">
        <property type="protein sequence ID" value="GAE67653"/>
        <property type="gene ID" value="JCM18909_727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17138" checksum="E2D1C452BC97B968" modified="2014-03-19" version="1">MRTGAAGVLVGFGGGATHTTRQVLGIQVSMASAIADVAEARRDYMDESGGRYVHVIADGSVGRSGDIAKAIACGADAVMVGSPLARATEAPGRGWHWGAEAWHPDLPRGARVHFEPVGTLAEVLNGPSRVPDGTMNLVGGLRQAMATTGYSEVKEFQRIELTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGV2</accession>
    <name>W4TGV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67762">
        <property type="protein sequence ID" value="GAE67762"/>
        <property type="gene ID" value="JCM18909_844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849236" evidence="1">
        <location>
            <begin position="30"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="21528" checksum="FE14C9366F1DF81C" modified="2014-03-19" version="1">MNHRRRARIAGLSVLCMAAGSFVAKPAFAAPSTSGTPSAPVASCNGDKNVDIFNFNDFHGRIATGANLFTPVVEARNANGADKVLLLDAGDNVGGSTFESGSLNDEPTIDMLNAAGVDANAVGNHEFDKGWKDLAERIVPHLNSPYLGANVYEKGTTKVAAPLKASTIIVKDGVRIGVVGAVTHDLPSWSPPPAFPTSPLVIRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH06</accession>
    <name>W4TH06_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67817">
        <property type="protein sequence ID" value="GAE67817"/>
        <property type="gene ID" value="JCM18909_902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="10929" checksum="12D99E9F116C279B" modified="2014-03-19" version="1">MLAGTTSGSSPGVEKKSSRDGVIIVWHRPSTESTVLDLPDLAGTHLEPLYPPACLVPDPGIHIADSSSSPRLNCPSPKPTGRVFRVRDLHDCVTDVAEMEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH22</accession>
    <name>W4TH22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extracellular protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67419">
        <property type="protein sequence ID" value="GAE67419"/>
        <property type="gene ID" value="JCM18909_478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07496">
        <property type="entry name" value="Peptidases_S8_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034176">
        <property type="entry name" value="Peptidases_S8_13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849240" evidence="6">
        <location>
            <begin position="29"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="185"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="411" mass="42080" checksum="3B1F7C0BE4DBB387" modified="2014-03-19" version="1">MAPRRTLTLMLCAITGASLVATAVPSNAAPGFTTSPLRTSDSIQSTSGFVVHLKDRSASAQRVRTAHTASAMQATSTSLRGSVDRAAKVRGAHVTESLVHANNSMSVQVSQGLNATAAKAFASEIERNPEVESVEPVLHMTINENTGVHPAAVSSAPNDQYWNRQWGLNSENGIDAPGAWATNTGSGVTVAVIDSGITKHPDLDGKVLPGYDFISDRYAAGDGNGRDSDPSDEGDWTRAGACTRRDVPSSWHGTHVAGIIGAATNNARGVAGAAPGAKILPVRALGHCGGTDVDIADGITWASGGEVPGVPTNHNPAKVINLSLGGPSNYCPITYQRAIDAAVSRGSTVVVAAGNEAMDARKSTPGNCRNVVVVGATGETGAQSYFSNYGSAVDVSAPGGDDRAGDMILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH27</accession>
    <name>W4TH27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type amino acid transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67424">
        <property type="protein sequence ID" value="GAE67424"/>
        <property type="gene ID" value="JCM18909_483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="14"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="173" mass="19354" checksum="ACFDA2426456E0E1" modified="2014-03-19" version="1">MWLYLRDVKIITDISYTILLTFAAMLLGTAVALLMAIMRQSRNPVLRGVSWAYIFVFRGVPVYTRVLGSARSVISHILHWGALRRSTIRQRRDRKGRHGARAAIIGLGLNEGACLTEITRSNLESVDVGQTEAAKALGMKPSLIMRRAIIPQAMRVIILRWATRPSACSSRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH8</accession>
    <name>W4THH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67952">
        <property type="protein sequence ID" value="GAE67952"/>
        <property type="gene ID" value="JCM18909_1054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8351" checksum="7E16163317E4AD52" modified="2014-03-19" version="1">MGDGLLSPTIDKEAATGRWNEGMPLGVAWPALDPKDLAGVDVSKFVNALVTTTGDASDASRERVTEESMKIDLDASVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ5</accession>
    <name>W4THJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67977">
        <property type="protein sequence ID" value="GAE67977"/>
        <property type="gene ID" value="JCM18909_1080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009323">
        <property type="entry name" value="DUF979"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06166">
        <property type="entry name" value="DUF979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12262" checksum="5C4EC3E730E4CCE8" modified="2014-03-19" version="1">MASFSSSPRSCGCGTARTTSASDRPLFWAILAFSFGYGSFVINKTAPALVEGIAVLLLVVLASCHFPGRGSTETTIDAEREKSAKKFGNKLFMLALIIVRGCHFRSGWDAQRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM9</accession>
    <name>W4THM9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IMP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67684">
        <property type="protein sequence ID" value="GAE67684"/>
        <property type="gene ID" value="JCM18909_762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12236" checksum="B6DE7FE7D79DA5EB" modified="2014-03-19" version="1">MSERQPIRRALVSFYDKSGLDQLAKALIDAQVEVVSTGSTAKELASHGVTVTEVSEITGFPECLDGRVKTLHPKVHAGILADRRLTTHREQLTALEVEPLTSSCAICTPSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN6</accession>
    <name>W4THN6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67928">
        <property type="protein sequence ID" value="GAE67928"/>
        <property type="gene ID" value="JCM18909_1029"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6282" checksum="1BFC92EABE10E83A" modified="2014-03-19" version="1">MTLMEIEHFFTVYKDLEPGKSVEGATWTDRDEAEAEIKASFERAKGTSYENLHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR7</accession>
    <name>W4THR7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Reactivating factor for D-ornithine aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68480">
        <property type="protein sequence ID" value="GAE68480"/>
        <property type="gene ID" value="JCM18909_1621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6799" checksum="2B671FA824B21464" modified="2014-03-19" version="1">MLTTLEIGSTITKANAFRMESGLLHHIGQGFAPTSVAAGDVRIGADAAIARCVSNAPHLRPPGRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU6</accession>
    <name>W4THU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67993">
        <property type="protein sequence ID" value="GAE67993"/>
        <property type="gene ID" value="JCM18909_1097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="259" mass="27835" checksum="79A82BC91392E7DC" modified="2014-03-19" version="1">MGDDRRPAVWLSIVLIAIGILGCFTSTAFSPLALRMTAQNPSGLTVLHGVATLAADVVLPVWLLWRHRHPFTITLVTAAISLVLPIGNTVPLIALACLLGRRRGAASWWATAAVTITTTIVGVVDAARSPKAASTIKTLLSPTNAPDTADLTVSWFTVAAFIAAGLIISIGSGLWRRTQRATTSLTRERDVAQATNAKLGDELSRREERERIAQEIHDQLGHRLSLLSLQSGALETQLRDNPTPSRRPRGTGWGSCSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ9</accession>
    <name>W4THZ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ccs1/ResB-related putative cytochrome C-type biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68053">
        <property type="protein sequence ID" value="GAE68053"/>
        <property type="gene ID" value="JCM18909_1162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="2"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="318" mass="35402" checksum="257EA4907CF6C70A" modified="2014-03-19" version="1">MPQSAQSAMKVSDFAANHPTLDRICRPLGMYHVYTSVWFSAIYLLLFISLIGCIVLRIVSHAKALRRQPPRVPARLDRLAAHASMTTSASAAEVSQRAQQWLTSHRYRFVVDDDGSLRAEAGRHRETGNLVFHIFLVFVLVGVGWNTLWGFKGTSVVVEGQGFFSNSITQYDEFKAGAMVDTDNLTPFSMKLRKFVVSFETGTVQRGAVRTFDATVDLTMGGKTQTRDLQVNHPLRIGSTKVHLLGHGYAADVVVRDGDGEVAYSGPVVFFATGRQLQVCRRHQSSRRPSGSSGLSRVLSTDWRHHGRWSDVPFPRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI66</accession>
    <name>W4TI66_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="7" type="ORF">JCM18909_939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67849">
        <property type="protein sequence ID" value="GAE67849"/>
        <property type="gene ID" value="JCM18909_939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24289" checksum="217F302D6F34393C" modified="2014-03-19" version="1">MTDKNVNPDDDQADENRDDNVDERFADIVGDVDIDADQSATDSQAPEELSRESQLEALLAERTEDLQRLQAEYVNYKRRVDRDRALSRQSGVDKVITDLMPVLDSIAMARQHGEVEGGFKLVVDELEKVANNHGLTSFGEVGDVFDPNLHEALMQMPMEGVSVTSVSQVMQPGYKLGDRVLRPARVAVSDPDPNATSADESSQADGESAQADEADETPRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI69</accession>
    <name>W4TI69_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68128">
        <property type="protein sequence ID" value="GAE68128"/>
        <property type="gene ID" value="JCM18909_1245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="165" mass="17217" checksum="402951D19938255C" modified="2014-03-19" version="1">MIVAAVCVVGNVVLASLAGYALTCMKFRGKKVVMGILLSVLLLPGEVTLTSQYLVIKGMGLANTLAGVAIPGVVGAINVLLMATACRAVPPSVLDAATVDGANTCRRFATSYGPTSRAWLRGRGVLVHRSLGRLSVATGCPQRSRQVHADSRHAVPQLDDVHRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI86</accession>
    <name>W4TI86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68670">
        <property type="protein sequence ID" value="GAE68670"/>
        <property type="gene ID" value="JCM18909_1821"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="168" mass="18816" checksum="F99780E5E11465BD" modified="2014-03-19" version="1">MAHECILDLRPLTTETGITVDDVAKRLIDYGFHAPTISFPVAGTLMVEPTESEDLTELDRFCDAMLAIVEEARMVQSGHWPADDNPLINAPHPAARLVADEWNHPYSRELGCYPGMRLGIQRDQERGLDVSTVTRIQAKYWPPVGRVDNTYGDRHLVCSCPPPEAFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI99</accession>
    <name>W4TI99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division protein FtsI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1836</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68685">
        <property type="protein sequence ID" value="GAE68685"/>
        <property type="gene ID" value="JCM18909_1836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="190"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="515" mass="55039" checksum="2C201728D87BAAA7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK6</accession>
    <name>W4TIK6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67954">
        <property type="protein sequence ID" value="GAE67954"/>
        <property type="gene ID" value="JCM18909_1056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850770" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5334" checksum="1BD30EEED13065AB" modified="2014-03-19" version="1">MKGRPVFVGCVAVLVLTACGGAGVSAGSHPHTAVASSSVSVVGMSRRRVRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL7</accession>
    <name>W4TIL7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68626">
        <property type="protein sequence ID" value="GAE68626"/>
        <property type="gene ID" value="JCM18909_1774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9400" checksum="D65BFADEB2638623" modified="2014-03-19" version="1">MLDRQLFGRDDTLGLVTDVKEDLVAVHLNDGPRDDVAVIEILDGGVHSGQKGLRATKVVNRHGSIGGIDGILLVGVDRVRGGGSVEEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIM3</accession>
    <name>W4TIM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68382">
        <property type="protein sequence ID" value="GAE68382"/>
        <property type="gene ID" value="JCM18909_1516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10134" checksum="2B995A5D89AE4CD4" modified="2014-03-19" version="1">MSRVLSTDEAKEAIRQIQSIVNGGLTDQIQALDNQGQRLSAPDVWDGPLASQFRGQVWPETRSALEKAKAELEQLRANLQKIATDIFTAGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIT0</accession>
    <name>W4TIT0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68696">
        <property type="protein sequence ID" value="GAE68696"/>
        <property type="gene ID" value="JCM18909_1847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17381" checksum="57E9A54B57C915C0" modified="2014-03-19" version="1">MLLDTLTGQMPMAEKSVGSRALRTPRRRTPGSWLRHLLRLDGGDGSSRRLLAQPFLDYYVILATTVLLCGIGALMGLSSSSVYSQSLGHGPYHFAIRQILFLIVGAIAAAVVSRLSETHLRQLGGFAYAVVCLMLVLVLTFFGFRRWKGKPVMAVSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIT4</accession>
    <name>W4TIT4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68059">
        <property type="protein sequence ID" value="GAE68059"/>
        <property type="gene ID" value="JCM18909_1169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7512" checksum="029E82FAEEBE8872" modified="2014-03-19" version="1">MILLRDDFIGLIMSDKPHNKKMATMSQISTIRYGIDADVIFLKLGTDILSGMKILKTEPQGLWLATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV0</accession>
    <name>W4TIV0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68079">
        <property type="protein sequence ID" value="GAE68079"/>
        <property type="gene ID" value="JCM18909_1191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17583" checksum="AC41992FCA973DD6" modified="2014-03-19" version="1">MIPIGITNRVPGAMPRQVDCYYSSADAVFADRYEASQRAHALFTTTTAFEGGWRVYSSGPGLILRIVTEDILGIRIRGHQLIVDPVLPVVFDGTTAVVHAGGRILHINYHVNADGHGVTRILVEGLPVEAKTLSPRYRRGGQTINLADLSNKDVTMDVWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIW1</accession>
    <name>W4TIW1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68089">
        <property type="protein sequence ID" value="GAE68089"/>
        <property type="gene ID" value="JCM18909_1203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8463" checksum="EE3617E5C40B46D8" modified="2014-03-19" version="1">MRAEGVNIVLFSFAAGEELSEHTAAMPVIVEALEGQLEITAEGRTVTLNPGGIVYFTTRLPHAVRAVEASKMALYMITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ41</accession>
    <name>W4TJ41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68179">
        <property type="protein sequence ID" value="GAE68179"/>
        <property type="gene ID" value="JCM18909_1299"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="127"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21490" checksum="9ABBA2775778E92E" modified="2014-03-19" version="1">MKYFDLGATEENLARVEQLGESIASLEGAIANLHQREADISQSINPPAFILKHYRERFMNRVGVELSPITVTYPVYKFQYVSAGGNSGQETTIPLTPQTIDALIETMSAKIRWRKSAAGQRALMTTRLRNYIKDRDNHTCQNCSVSVAQEPHLLLEVDHIMPVSRGGLTTEENLQTLCWRCNRTKSNKVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ47</accession>
    <name>W4TJ47_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68970">
        <property type="protein sequence ID" value="GAE68970"/>
        <property type="gene ID" value="JCM18909_2148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11720" checksum="62275A5390745064" modified="2014-03-19" version="1">MIAIGGSIGTGLFLGTGGRLAQGGPGLAISYAVCGIFAFLMVRALGEMAIRRPSSGAFVSYAREFMGEKGAYATGWFFFLDWSVTVMADITAVALYLHYWTPLRAIHNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD4</accession>
    <name>W4TJD4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68523">
        <property type="protein sequence ID" value="GAE68523"/>
        <property type="gene ID" value="JCM18909_1667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="177"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="311" mass="34089" checksum="3B2D5E86E7008E3D" modified="2014-03-19" version="1">MVWDKNTGEPVYNAIVWQDTRTQKICNELAGDKGADRYKEICGLGLSTYFSGPKVKWILDNVEGARARAEAGDLLFGNMDTWVLWNLTGGTNGGVHITDPTNASRTMLMDVRKLQWDDSMCEVMGIPKSMLPEIKSSSEIYGYGRKNGLLIDTPISGILGDQQAATFGQACFQKGMAKNTYGTGCFMLMNTGEEAIFSENGLLTTVCYKIGDQPTVYALEGSIAVAGSLVQWLRDNLKMFETAPKIEALANTVEDNGGAYFVPAFSGLFAPYWRPDARGALVGLTRYVNRGHIARAVLESTAFQTREVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE0</accession>
    <name>W4TJE0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68657">
        <property type="protein sequence ID" value="GAE68657"/>
        <property type="gene ID" value="JCM18909_1808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12339" checksum="EA551AEAD7733E6E" modified="2014-03-19" version="1">MGGPGTGKTVVALHRAAFLLYSHRTRLENGGVLVIGPSSVFMSYIERVLPSLGEDSVTLRSVGQVPSDILRFSSDRLDEPVLPISRAALRWLTCSPDWSICPCRRIPIPCSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG4</accession>
    <name>W4TJG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68294">
        <property type="protein sequence ID" value="GAE68294"/>
        <property type="gene ID" value="JCM18909_1422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HrpB_C" evidence="2">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18354" checksum="EF1313B01F0F422C" modified="2014-03-19" version="1">MFGDPWPDVSDEALLARAEEWLDLDALAAGRGSDATSGLRGLLGWQESARLDEVVPETITVPSGSRIRVDYPEPGSDTSPVLAVKLQECFGWTDGPTVCDGRVRVVLHLLSPARRPLAVTDDLASFWASVYPAVRVENRGRYSKHPWPEDPMTATPTKRTNRALWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI3</accession>
    <name>W4TJI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylmuramate-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68702">
        <property type="protein sequence ID" value="GAE68702"/>
        <property type="gene ID" value="JCM18909_1853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12015" checksum="1D663A2A803F05E7" modified="2014-03-19" version="1">MTGQGRVIACFQPHLFSRTRDFAGEFGSALTLADRVIVSDIYPAREDPIPGVTGEMVHDAVLAADGNSRYVPDKQDLPEALAEEVRPGDLVITLGAGDVTLVGPVLVGLLEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK96</accession>
    <name>W4TK96_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ORF">JCM18909_2107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68932">
        <property type="protein sequence ID" value="GAE68932"/>
        <property type="gene ID" value="JCM18909_2107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="79"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="18276" checksum="12538ACE795B622B" modified="2014-03-19" version="1">MYDGPLQELIDALSRLPGIGPKGAQRIAFHILDAPAEEANELADALREVKEKAKFCKICFNVSSDEVCQYCRDPRRDQSMICVVEESKDVIAVERTRQFRGLYHVLGGAISPLDGKGPADLHIRELCQRLADETVTEVILATNRTLRGKQRQRIFPASSRPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA0</accession>
    <name>W4TKA0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69375">
        <property type="protein sequence ID" value="GAE69375"/>
        <property type="gene ID" value="JCM18909_2584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpB_D2-small" evidence="1">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12299" checksum="74F5EB9D0F2A0329" modified="2014-03-19" version="1">MHPLDRKALVRILTEPRNALTRQFEKLFELDGVELTFTEGALGAIADKAVARGTGARGLRAIIEETLMDVMFDVPSRDDVSRVVVTQEAITGEGKCQYLSTPVFHGRGRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG2</accession>
    <name>W4TKG2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68649">
        <property type="protein sequence ID" value="GAE68649"/>
        <property type="gene ID" value="JCM18909_1799"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="292" mass="31914" checksum="61256C565A260B89" modified="2014-03-19" version="1">MSMTMSTDPLVGHTLEGRYEIVSKIARGGMATVYRAQDLCLPRIVAVKVMHEGLDAELAERFDSEAKAAAQLVNPHVVSVFDQGMDGDRPFIVMEYVPGCTLRHIITQEAPLTPVRALDLLEPVVSALASAHEDGLVHRDVKPENVLISDRGQIKVADFGLARAVGNHTMSATSGQLIGTVSYIPPERVTRGSSDERSDIYSAGIVLFLRCSLGTSPILAIPPFRWHGPTSIRMFPHPHSTWPMAPKLSTISHGSFRDTWTAWYVPAPRAILGSALRMGGPYSTFFVVYVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ0</accession>
    <name>W4TKJ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69460">
        <property type="protein sequence ID" value="GAE69460"/>
        <property type="gene ID" value="JCM18909_2676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="261" mass="28639" checksum="CDB9567AC8462096" modified="2014-03-19" version="1">MCHREPVSVRVEELTRAFGNLVAVDHLNFDIPAGRMTGFVGANGAGKTTTMRMIGGVLKPTSGQVLWSGRPITAEDRRTIGYMPEERGLYPKQPVIDQLVYLARIKGASAQTARTEAMEYLDRFGFADHAREQVQKLSLGNQQRIQVTASLLADPAVLILDEPFSGLDPVAVDAMADVLREVGPRRYRVEARGDLGWLRSLPGLTVVDVDGTTAVIEFPDPNQIDCLLDVIVTESMNRGGLVELTHIRPSLGEIYREVAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX7</accession>
    <name>W4TKX7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69187">
        <property type="protein sequence ID" value="GAE69187"/>
        <property type="gene ID" value="JCM18909_2378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019885">
        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00519">
        <property type="entry name" value="HTH_ASNC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14854" checksum="A7ED1B7B54798554" modified="2014-03-19" version="1">MKKDGRMSWTELGHQTGLSTSAAQQRVKRLEAKGIITGYHATLNLEAIGAGITAFIFLNPIDPEEDETIPGILRTFPEVRGCHSIAGAASYLARVQAPSAGHLDQLLTRIRKECLCGTETVVVLDTMFDDLGMLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL26</accession>
    <name>W4TL26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69426">
        <property type="protein sequence ID" value="GAE69426"/>
        <property type="gene ID" value="JCM18909_2638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="11213" checksum="2FF523CD6C6BB7F1" modified="2014-03-19" version="1">MRVMKVYIILVKVCTTSVGTISPRRTRHHAPYLDRMSDMSTPRRAAPEDDTDLADVARSWRRYLILVICGVIVAVLGLGFFWLSCVVVIVRSSCGSLSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL27</accession>
    <name>W4TL27_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69675">
        <property type="protein sequence ID" value="GAE69675"/>
        <property type="gene ID" value="JCM18909_2920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="7">
        <location>
            <begin position="35"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="6">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="318" mass="35761" checksum="3120C01C559E2E52" modified="2014-03-19" version="1">MAATRTASKNTSAISPQSGRISFAKIHEPLEVPNLLDLQVESFNWLVGNEIWQSRVDAALAEGRTDINTKSGLEEIFEEISPIEDYSQTMSLSFRDHRFEDPKHSVDECKDRDTTYAAPLFVTAEFMNNETEEIKSQTVFIGDFPLMTSKGTFIINGTERVVVSQLVRSPGVYFEKTADKTSDKDIFTCKVIPSRGAWLEFEIDKRDTVGVRLDRKRKQNVTVFLKALGWTATGFLRSSALMSRSVRPLRRIMASRPRTRLSLTSTRSCAPVSRRPVTPRSSCSRITTSTRSATTWPRLVGTRSTRSSVCPCPSISRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL89</accession>
    <name>W4TL89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68909">
        <property type="protein sequence ID" value="GAE68909"/>
        <property type="gene ID" value="JCM18909_2082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8925" checksum="A4A02B8098008256" modified="2014-03-19" version="1">MSIGMAIGAGIVFLPVKIGLVGLWVFLVSSVIAYPAMYLLQRLFINTLAESPECKDYPSVISGYLGKNWGFFLSVSSISSCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF1</accession>
    <name>W4TLF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68979">
        <property type="protein sequence ID" value="GAE68979"/>
        <property type="gene ID" value="JCM18909_2157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6669" checksum="89AEC25377EBCAD6" modified="2014-03-19" version="1">MPSFAMGLFDGDGCEDGWAELTPDFNGELADSGSLFAHPAMAIETVVTATTAPVIVLLRKAKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK4</accession>
    <name>W4TLK4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69318">
        <property type="protein sequence ID" value="GAE69318"/>
        <property type="gene ID" value="JCM18909_2519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="345" mass="36743" checksum="EB6027F167E07BA0" modified="2014-03-19" version="1">MPQAWSPSPQVHAFEDEFSSQVVDGVHCVAVNSGTSALHIGLLASGIGEGDEVIVPSFTFAATGNSVALSGAKPVFADVDPVTFTLEPASIEASITDKTAAIMPVHLYGLPANMAEIVAIATKHGLKIFEDCAQAHAASIDGKHVGTFGTFGAFSFYPTKNMTSGEGGMITTSDPEIARKAAMLRNQGMEKRYANEYVGLNNRMTDIHASIGRVQLTKLAGWTKTRQENAAFLSSNITEAITPAVPDGYVHVYHQYTIRLEGATGEERDRFVIALKEEYQVGSGVYYPIPNHRLPSLAPYVPGLELPNTEKVAAECVSLPVHPSLSQADRERIVAAVNACAKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT0</accession>
    <name>W4TLT0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69467">
        <property type="protein sequence ID" value="GAE69467"/>
        <property type="gene ID" value="JCM18909_2685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="272" mass="29389" checksum="432B0017BEB447E6" modified="2014-03-19" version="1">MPFVTLGSLINFCDVLLAGGTSRTHHSEVGSSYIHFNFTPDGDKTTASLFGDVPRGVLLDRHPIFLGGQGGAVGPVTTGFGTVVGAGSILRDDVPEDDQLVLPAPPATRQRPVAPNSYSKLNRIIAHNVSYLGNLSALEAWYRQIRRLFMSRDRLSGLVWQGALDNLVSARKERVKRLESLIGKVQPTDAGRAQLIDNRDAFLSSLETADSPAPAEIVRLCGAAANSGATYLDVIQSFDEAARNQVVEWLGNIVTAQQDRAQEVVDQLPLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU4</accession>
    <name>W4TLU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69721">
        <property type="protein sequence ID" value="GAE69721"/>
        <property type="gene ID" value="JCM18909_2970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="232"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="306" mass="31714" checksum="3F7A3BCD21C68D72" modified="2014-03-19" version="1">MSPSKSHRNDYQRQVVSTPDVRMVPVAITACGMAAVGIGGHRWMILSAGIGCLAAGMIAVKRKAWLVVVSAAVGLTVLLSAGMRDLVVHHTGVAELAQEGAAVTVTGRVAADPRIFEVSGSGGSTVMITLVAHRIVAEAQAIDQSVRVVVMASGSTSGPATTVVVGQQVQVRGLLTPPREGRAEAAVLKLRAPPRVVAPPGPLDRGVNRFRSGLVSAVAGCPEGQRAIVPSLVVGDTAAVSKEMSEDFRVTALTHLMAVSGANLASTTALLWWIGAWCGLKRRGLRATSVAGVVVFVVVCRAEARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV8</accession>
    <name>W4TLV8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69950">
        <property type="protein sequence ID" value="GAE69950"/>
        <property type="gene ID" value="JCM18909_3223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019675">
        <property type="entry name" value="DUF2550"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10739">
        <property type="entry name" value="DUF2550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6040" checksum="BE78D791AF0D1113" modified="2014-03-19" version="1">MALASNAYEIVTLETGHRGRSSVCQIVVDPRVVTGLMSWLEAAPPGGVEYATEGHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM52</accession>
    <name>W4TM52_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ORF">JCM18909_2697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69478">
        <property type="protein sequence ID" value="GAE69478"/>
        <property type="gene ID" value="JCM18909_2697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="362" mass="38806" checksum="BA9B4A3EC06E26B8" modified="2014-03-19" version="1">MSNDYYEILGVSHDASADEIKKAYRRKAMKLHPDVAGPGSEEEFKKRSKRLMKSSRIRKSAPFFDRGGDPNARMGGFGEGGFSSAGFDFTNLVDAMFGGSSPFGSGGGRGPRSRTRRGQDALVRMRLSLAEAVFFGVTKPLEVDTAVVCPKCQGKGAQSGSEPVTCDTCQGRGEVITVQRSFLGDIRTSQPCPTCHGYGTIIPDPCQECSGEGRVRTTRTINVKIPAGVADGNRIHLDSQGEVGPGGGPAGDLYIEMTVSSHDVFTRHGDDLEMVVTIPMTAAALGTKVPVHTLEADRETSPRILRPSLLRCRPAPSPEPGSSFPNEVCRGFVATGVVILVSRSSSRHRRNSTPTRRICCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC7</accession>
    <name>W4TMC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69871">
        <property type="protein sequence ID" value="GAE69871"/>
        <property type="gene ID" value="JCM18909_3134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16083" checksum="21F3C617F4FAB656" modified="2014-03-19" version="1">MAVTPVLACYRTRDAAIGGMTAWQVTTGPDGPHTNVVGSCPLGDASWVTPLYHLVVVLCECDGTLVVVHPGREFQVVGTVQLEGQWPCTVPSIPLGVSWPSRITPQARSNSSTYQIPPDQPSEASSISVRAVFSLDRWQIVKKVPMLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ8</accession>
    <name>W4TMJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69921">
        <property type="protein sequence ID" value="GAE69921"/>
        <property type="gene ID" value="JCM18909_3188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5565" checksum="F202724B5B865628" modified="2014-03-19" version="1">MVTNLDQIKVSGEDGKVPKVEGAWPLAIAKTESKVLKEGTGEKKSTRTPPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK6</accession>
    <name>W4TMK6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69658">
        <property type="protein sequence ID" value="GAE69658"/>
        <property type="gene ID" value="JCM18909_2903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8230" checksum="99277FBC0FCC8C3E" modified="2014-03-19" version="1">MSVAVALAAVVRAESASGLGEVLETDRALGRSFMRNSDFCEGVRAQLVDKDRNPHWSHESVADVPARQVEGMFDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMP3</accession>
    <name>W4TMP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69812">
        <property type="protein sequence ID" value="GAE69812"/>
        <property type="gene ID" value="JCM18909_3067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="14027" checksum="60BA862FBD1573EC" modified="2014-03-19" version="1">MPYPQLVTSKRAEDARLRIEFEERARRQEAVQAQRLIDDFLVMARAQGMTPVPLRAQLMDGHEARTDKRGWYLNAKHSLAIGENGEYYHLVVPGGFAARMRGVKLHPSLPPDAYWQRRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR5</accession>
    <name>W4TMR5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible oxidoreductase of the aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70275">
        <property type="protein sequence ID" value="GAE70275"/>
        <property type="gene ID" value="JCM18909_3582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="14"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="18123" checksum="7F2F71D4A55F9F6C" modified="2014-03-19" version="1">MKYRQIGPFRTSAIAYGSMPLSIEGRPDRETAINILHDVLDAGCTHIDTAWAYYESGGVEQYGERLVADAWRHGMVTIRQSRWPLKSGTFAVSTTRGNPFGMLTGHRNDCVATRSSRLRHCVPTRSIYCICIAPTPRSNTKHGADSGRNPRRRFGAYRRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY1</accession>
    <name>W4TMY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69549">
        <property type="protein sequence ID" value="GAE69549"/>
        <property type="gene ID" value="JCM18909_2777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7361" checksum="D5BBAFC43EC743A8" modified="2014-03-19" version="1">MMKATMPRRTALSALPYFNPRLVMGTLTSISDRHIPRVFHVRDTNTLLSKSRRGHEADMDHNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN34</accession>
    <name>W4TN34_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70385">
        <property type="protein sequence ID" value="GAE70385"/>
        <property type="gene ID" value="JCM18909_3703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6547" checksum="812DCC0A65414934" modified="2014-03-19" version="1">MFVDAATTYAATYPVSRNTSVWADKEADYVNPAFSGEMPVPETARKLATFMNDALAKEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN69</accession>
    <name>W4TN69_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69858">
        <property type="protein sequence ID" value="GAE69858"/>
        <property type="gene ID" value="JCM18909_3117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8298" checksum="FF6F0B27F14687FD" modified="2014-03-19" version="1">MVNTPSRAKPPRHWIDLSIEERVQAVKDLGVPAFRARQISAHVFLSGGRSTRLSGLTCLRRLVRRSPTPGFRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN96</accession>
    <name>W4TN96_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I restriction-modification system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69689">
        <property type="protein sequence ID" value="GAE69689"/>
        <property type="gene ID" value="JCM18909_2938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="9108" checksum="C02CF717AE933563" modified="2014-03-19" version="1">MESNEVRLYKKKAHPSVIRDVYKFSLPEVTVQREVVEKLLFETLVNDLSSGIPAEIAARRKQYEYYRDKLLTFKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNE4</accession>
    <name>W4TNE4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3566 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70057">
        <property type="protein sequence ID" value="GAE70057"/>
        <property type="gene ID" value="JCM18909_3341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021949">
        <property type="entry name" value="DUF3566_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12089">
        <property type="entry name" value="DUF3566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3566" evidence="3">
        <location>
            <begin position="37"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17093" checksum="F01540FA6EE7FB54" modified="2014-03-19" version="1">MRRTDSRGAQGEKAPNQQEPHRSPQAHQPARAPRRTRKARLRLTRVDPWSVMKTSLLFGVAGAVIFFIATWIIWGIIGASGAFDSMNKVVNDLISSPSSTSKFELSDYVNTGRVLGLTALIGAINAVLFTAISTLFSFLYNLAAQIMGGLEVTLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ5</accession>
    <name>W4TNJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribonuclease E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70530">
        <property type="protein sequence ID" value="GAE70530"/>
        <property type="gene ID" value="JCM18909_3868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="14228" checksum="3D054BC2FB952623" modified="2014-03-19" version="1">MRKRNLLRHEVTNLPHHRSSHTLQFPRDNEDARGQASDLLTEILSEGRGQRMHAKLWIEVDEGGRRERQMVRLGDKGGYDCGFALEDVRMFRDALSWLEDQAGQQYGNVADRGRLVGVEIDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL0</accession>
    <name>W4TNL0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70127">
        <property type="protein sequence ID" value="GAE70127"/>
        <property type="gene ID" value="JCM18909_3423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6793" checksum="582C6C7C4433EAD7" modified="2014-03-19" version="1">MSPDNTSDDTRAGNAAHDHSTDSRHSETAAEAETEPWIEPDDISGFAKPCSATALWHTLSEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNS8</accession>
    <name>W4TNS8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ORF">JCM18909_3126</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69864">
        <property type="protein sequence ID" value="GAE69864"/>
        <property type="gene ID" value="JCM18909_3126"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="237" mass="25553" checksum="2B621475C4499980" modified="2014-03-19" version="1">MPERYNRVLLKLSGEVFGGGGIGVDADVVSAKAREIAEIANSGVQVAVVVGGGNFFRGAELQQHGMQRDRADYMGMLGTVMNCLALQDFCEKAGVDTRVQTAITMGQVAEPYIPRKAERHMEKGRVVIFGAGSGMPYFSTDTVAAQRALEIGADALLMGKQGVDGVYDSDPKTNPNAHKFDELTYDEFLSRDLKVADATAVAMARDNDLTMVFFNLEMPGNIGRVINGEDIGTTVHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT5</accession>
    <name>W4TNT5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70386">
        <property type="protein sequence ID" value="GAE70386"/>
        <property type="gene ID" value="JCM18909_3704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="31147" checksum="83326FDB0344040A" modified="2014-03-19" version="1">MNCPMFFWMNGPNIQLYAGNGMLAPIDKVTDAGVKWSDYPEALVKLYTYDGKHYGVPKDFDTIGVFYNKKIFKDAGVELPTAGWTWDDFHDKAKKISDWGKSKGIYGCATTINGDGQGTYYNTIFQAGGFVIKDGKSGFDDPKSIEGLQCWADWVKDGSVASPKVITDTKLSQMFKSGKSAMYWSGDWTASELAEEFKGHENDYDVVALPKKRQEGHCHSRPGMGGFGQVGQPSRRTSPRRPHGLQAGTGDGSSEWYRHPGFPRDSGSLDQGVPAVELQDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV7</accession>
    <name>W4TNV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69889">
        <property type="protein sequence ID" value="GAE69889"/>
        <property type="gene ID" value="JCM18909_3154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9254" checksum="B406C9BFADF66E80" modified="2014-03-19" version="1">MAARALSRHATVTDPEPRVDYTRVLVDSSAGPGPGLLGLIGLLLGYAVVVPGLLYAFLGVGWLLERTDGEGFSAYYTRAAGYHTVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX3</accession>
    <name>W4TNX3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70242">
        <property type="protein sequence ID" value="GAE70242"/>
        <property type="gene ID" value="JCM18909_3540"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="294" mass="33016" checksum="8197872D42B3AE46" modified="2014-03-19" version="1">MAIMSSMINAMSTHDRPRITDEESFTDAAAKLMSKVRTIAAASYKASIGEPAIYPRYDLKYVENFMHMMFSLPYRAYEPDPVAARALNLFFVLHADHGQNCSTSTVRMVGSSGANLFTSCSAGVCALWGDRHGGANVNAVLALQRIRDSGLTPRQYLAKAKDSGERISGFGHRVYRNWDPRARIFRSVVGPLLDTMHKPDPLLDVAMELEEAVLADDYFIERRLYPNVDFYSGIVLRALGIPLNMFTVMFAIGRMAGWIAHWKEVFEDPTTRISRPRELYDGPVSTPWVPRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY0</accession>
    <name>W4TNY0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70118">
        <property type="protein sequence ID" value="GAE70118"/>
        <property type="gene ID" value="JCM18909_3409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="267" mass="29385" checksum="C6AC9823E40B52E4" modified="2014-03-19" version="1">MSSLPSQLAARIESAIGVDPQLRPATKPQFGHFQSNVALRLAKEEKRLPRDVAADIVAKLDIEDLCETPEIAGPGFINLRLRTDVLARVASDLVTDPNAGIAQAEKPERVVIDYSAPNVAKQMHVGHLRSTIIGDCFNRVLSAQGHTVIPQNHIGDWGTQFGMLIEYIVEKRMDVEDFDLSGVEQLYQDSKKTFDADPQFADRARRRVVKLQVGTPRLCGSGVLSLTSPWRVQRHLRPSVGAADGRGRGRRVQLQRRPAAGCGRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY5</accession>
    <name>W4TNY5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome (Plasmid) partitioning protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70123">
        <property type="protein sequence ID" value="GAE70123"/>
        <property type="gene ID" value="JCM18909_3419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="12"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22638" checksum="4D5A9C5BA3D7128B" modified="2014-03-19" version="1">MPLTLPRPTSQRTVVVANQKGGVGKTTTAINFAVALAMSGLKVLVIDTDPQGNASTALGIDHEVGTPGTYEVLLDEEEIGLVAKPSPEALGLEVVPATIDLSGAELQLVDVKGRERRLRKALRKYLKNHDVDYVILDCPPSLGLLTLNALVAADEVLLPIQCEYYALEGVTQLMRTIEAVRHEMNKELRLVDPHDDVRWSNTTFYPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP05</accession>
    <name>W4TP05_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CobN component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000089">
        <property type="protein sequence ID" value="GAE70720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70720">
        <property type="protein sequence ID" value="GAE70720"/>
        <property type="gene ID" value="JCM18909_4106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8480" checksum="CC8CADDE491235C0" modified="2014-03-19" version="1">MFDEVCDTYIDDPEMVQRLSTLNPHSLASMAQRMVEAHDRSLWNASAEHLDKLHDLTFKLDSSLEAGTQEIDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP37</accession>
    <name>W4TP37_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70476">
        <property type="protein sequence ID" value="GAE70476"/>
        <property type="gene ID" value="JCM18909_3803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="23140" checksum="1FAE152338E9EA9B" modified="2014-03-19" version="1">MVTMYPPQHVDAVLFDMDGTLLNTLPAWCVASEYLWGTSLADADSAKVDGGTVDDVVELYLRDHPQADPQATVERFMDILDANLAGNTEPMPGADRLVKRLSGHVPIAVVSNSPTRLVRDGLASQGWLELFDTVLGVDEVAAGKPAPDPYLTAARRLGADPSRCVVIEDSAFGLRAGRAAGAWVLTVGRKLKGQGDMWVPGLDDERVTFWESHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPD7</accession>
    <name>W4TPD7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004814">
        <property type="entry name" value="Oligopep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="PTHR31645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00733">
        <property type="entry name" value="TIGR00733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="662" mass="68165" checksum="EFC3FADFA4EE7236" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPF2</accession>
    <name>W4TPF2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Octanoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipB</name>
        <name evidence="8" type="ORF">JCM18909_3951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70601">
        <property type="protein sequence ID" value="GAE70601"/>
        <property type="gene ID" value="JCM18909_3951"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="7">
        <location>
            <begin position="65"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="272" mass="30262" checksum="49B8FAA8376DF6AC" modified="2014-03-19" version="1">MQQDPPTPQPHTPQIVDGVKPRGWVDHPAGLHFEYLGIADSRPTRTEYNECWAHQREVHAEVSAHQRPNTVIYVEHDPVYTAGRRTRKEAYPFDGTPVVPVDRGGEITWHGPGQLVGYPIVFLQRGIGVVDYVRRVEEAIIRLVAQYGLRAGCVPGRTGVWFPSDGVGPERKVCAIGIRVSRQTAMHGFALNIDPDTAGFDNIIPCGISDADVTSMARELRRLHGPDAEVPSLLEVAGNLEPILTEMMSFQPYEMSPDIPRREHPAFLHPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPL1</accession>
    <name>W4TPL1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosol aminopeptidase PepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70154">
        <property type="protein sequence ID" value="GAE70154"/>
        <property type="gene ID" value="JCM18909_3450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="6">
        <location>
            <begin position="83"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="237" mass="24430" checksum="D4E1AC2B9A252B23" modified="2014-03-19" version="1">MGKGITFDSGGLNIKTAANMYTMKCDMGGAAAVLAAIGAIARLGLNVRVVAYGCLAENMPSGSGWRPSDVVTMYDGTTVENGNSDAEGRIVMADGLARAREDNPDFIVDISTLTGACMVALGNHTAGVMTSGAQAADTLLDASEAAGEDFWELPITDEVREGLHSDIADVKSSGAREGGAMLAAAFLQRFVTPGTDWAHLDIAGPAYNEASAHDYTPIQGTGFGVRTLVQLAAHMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM0</accession>
    <name>W4TPM0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_3460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70164">
        <property type="protein sequence ID" value="GAE70164"/>
        <property type="gene ID" value="JCM18909_3460"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE70164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="544" mass="60640" checksum="39F46B0E5FF942DF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPY4</accession>
    <name>W4TPY4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70438">
        <property type="protein sequence ID" value="GAE70438"/>
        <property type="gene ID" value="JCM18909_3756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14210" checksum="B10815895586E014" modified="2014-03-19" version="1">MRLSFVDDSGKLVGLLAKSWKLSDDGLRLTFRLDPNARFASGARVTSAAVKASLERMRGASASPVNQANLAAIKAIHTPDDSTVILDLSNRDNFLLFNLASTSGVVIDPATKDLATRPQGPGPMSSLSSPQDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPY5</accession>
    <name>W4TPY5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen alpha 1(I) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70597">
        <property type="protein sequence ID" value="GAE70597"/>
        <property type="gene ID" value="JCM18909_3947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17638" checksum="64BC8372EF8645B6" modified="2014-03-19" version="1">MSERLRGRLFEPTRTPEQDGVLQRLETLLALIEGWVDEVTFQVARTWLPSHDQLAEAVRRRRATSGPAEVFFQSLLGLELRPRRVRDAANLWAALREARGTVGRDHVWNHPDLVPTAADLDDPLGYVSGDRQDPSEGGDDLDAELEKLLRDHGHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR22</accession>
    <name>W4TR22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_4072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000067">
        <property type="protein sequence ID" value="GAE70694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70694">
        <property type="protein sequence ID" value="GAE70694"/>
        <property type="gene ID" value="JCM18909_4072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="46"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12896" checksum="E5E5E99061DE8347" modified="2014-03-19" version="1">MLTAFSQRDLIKRAKEAGAMAYVVKPFDASDVIPAIEIAMARFAEIRGVEDEVMDLEERLESRKIVDQAKGILQTSLDLTEPEAFRWIQKTAMDLRKSMREVAQGVIDHAESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE33</accession>
    <name>W4TE33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67220">
        <property type="protein sequence ID" value="GAE67220"/>
        <property type="gene ID" value="JCM18909_265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="17046" checksum="650FF091700AAED1" modified="2014-03-19" version="1">MILGFRTARSGMTLAVGADHEIITENEYASLIDTEPGMGKRVYRVEATQGRPIRIDKAVAYHTSRGVPVHELFDRVRRSLDRVREQGHNVYYDEQRAWLDDYWATADVEVEGAPTGIQQAVRWNLFQIAQASACRSTWHSGKRCNRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE40</accession>
    <name>W4TE40_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67230">
        <property type="protein sequence ID" value="GAE67230"/>
        <property type="gene ID" value="JCM18909_275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="328" mass="36555" checksum="F495A2BAB1DD16A3" modified="2014-03-19" version="1">MARILLEGIPIAMDGSWQLHRRRAAPEPVRFAQRFGGEQSNTSIMVGDAIIIKMFRRLEPGDNLDITVHSALNDAGISSVATLYGFMSGQIPAEQHTPVDLAMIIERLPQPRDGWELITAKAVDLVDVTDLVAGLGQCLRTIHEALRHTFDTVEIDGSRVADDMMRRLDAAVVTAPALARYRGTLTARFEKLHGRHLAAQRIHGDFHLGQTLLTPDGWRIIDFEGEPLKPLAERRLPDSRWRDVAGMMRSLSYATSAHARPTAPQTLTWARRANEAFLTGYGWPNTAEQDVLAAYEADKASYEIVYETLNRPTWVDIPLSVIRAMGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEA3</accession>
    <name>W4TEA3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67295">
        <property type="protein sequence ID" value="GAE67295"/>
        <property type="gene ID" value="JCM18909_341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10488" checksum="50BE8C1292CC8160" modified="2014-03-19" version="1">MSANDIWLLDLTDASKAPMTIDMRRGRCTRGTLEELRGVLRNHPGSSEVRLRLIDGKVTTTFRLADELKVTQGQPLMADLKALLGPSCVPRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEG4</accession>
    <name>W4TEG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67181">
        <property type="protein sequence ID" value="GAE67181"/>
        <property type="gene ID" value="JCM18909_223"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16102" checksum="7FE6AEB32347ECEF" modified="2014-03-19" version="1">MVTLFIFSDSLDGNMARKLGRHSQWGSFLDSTLDRFGDAAIFTGVALYFAGPGNSVLWTAMACAALVFGMATSYVRAKAESLALEAKVGIATRADRLLVSLVAIEITGLARVGAFPHWCVVALPIALCYLTLAGAITVVQRMVAVRRVCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TER9</accession>
    <name>W4TER9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67291">
        <property type="protein sequence ID" value="GAE67291"/>
        <property type="gene ID" value="JCM18909_337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="22442" checksum="68874E3AFD87CB80" modified="2014-03-19" version="1">MARSDFVHLHTHTEYSMLDGAASNEKLFAEVARQGMPAVAMTDHGNMFGAYEFFQISKKYDGDQNPLVKPIIGIEAYVAPSTRKSRVQEFWGTSRDVGDPDAEGGKDVSGGGRYTHMTMWAKDSEGLHNLFRLSSLASYEGYYMKPRMDRELMGQYSGGIIASTGCPSGEVQTRLRLGQFEEACQAASDYRDIFGRENYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEX7</accession>
    <name>W4TEX7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2510 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67510">
        <property type="protein sequence ID" value="GAE67510"/>
        <property type="gene ID" value="JCM18909_574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2510" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6745" checksum="325AF077CE9FDFF8" modified="2014-03-19" version="1">MASGPQAGWYRDPDGTPDRYRWFDGERWTDRTTTSLILPRSKAEKAIGDMTTVAALVGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEZ2</accession>
    <name>W4TEZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67525">
        <property type="protein sequence ID" value="GAE67525"/>
        <property type="gene ID" value="JCM18909_590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="119"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="298" mass="31753" checksum="1865ADB03419DB2B" modified="2014-03-19" version="1">MPLGAASARIDHRVHAVAARHLHRVVTSEWGIPDVVHAHFARFAAAAARAGFPEPLVWTEHDSHLAHPDQRLNEDIIIAGDRADAVISVSQGLCDRLAGHGVTSTVVPNIVDVELFDRPDRRHEGTIVVSVATLNPGKGMIELAQAVEHLPEVQLRIIGDGPQRHQLEAIAADNPRIVLLGPQSRDRIAEELAGADAFALASHAETFGVACAEALAAGLPVLTTACGGPQEFIDDSNGVVVPIGDVDALTEGLRQVLARAWDHEQIAGYARSRFAAAPVVDQLETVYRKAVADHDMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF00</accession>
    <name>W4TF00_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F5/8 type C domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67535">
        <property type="protein sequence ID" value="GAE67535"/>
        <property type="gene ID" value="JCM18909_601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="Beta-N-acetylglucosaminidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="3">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="242" mass="26074" checksum="0D3DC7192C833F26" modified="2014-03-19" version="1">MTSAGADMSLSGKVTVVAGADADAKAVEQVVSVLRDLPGARVSVSRTPDASGDQVWVGTAETTPGIDGLVASLGGSKAATLPADGYVIASGRRSGYNVIALQGKDARGTFYAVQTLRQLVRHDKVASVTVRDWPLMPIRGGIEGFYGIPWSHQARLDQFTFYGRHKMNTYIYTPKDDLLLRAKWRTLYSGDDLARMKELVEGANANHVDFTFALSPGNDICYSSDADFKLRLPSSTSSVPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF63</accession>
    <name>W4TF63_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67167">
        <property type="protein sequence ID" value="GAE67167"/>
        <property type="gene ID" value="JCM18909_209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="434" mass="47598" checksum="69D3778A6E20FB52" modified="2014-03-19" version="1">MEVNADNLDEQVASARENLKESEQLQELKNYLLAVFNKACAVSTEQDDGDVISNIAKNGRLAKPSTALSQGPLRRMLQRAISGEQSVAHSLGLNDAGIENAERVLADGGDVVESVLLEDYDSSEPMAVYDPARRAVVLNQTHPFVTNYIGGKTVAEPLKLLGLSEILTQAYLLDENISPDVIERVMSRRDAFLRELTMRFPRSAPIIAQRLRDATNDENALEDAVGDALELLGFSVTRLGGSTHGTDGIATARLGKRSATSASYAFTYDAKSTKDSVRVVLSEESTGSEESRLPGRIRADTARTSILRVHREKAAAKHGLEIAPSFTLLVAPDFQGALDEEGLINEVCANDEITAIRVDDLARLVELFALQGLNPADLRPLFDTRKPEETRAWVDRQSTQARIPRPPVSILVETLVENSEKKRRLLYLRASQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF64</accession>
    <name>W4TF64_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67068">
        <property type="protein sequence ID" value="GAE67068"/>
        <property type="gene ID" value="JCM18909_103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22845" checksum="58E5300D75B333F9" modified="2014-03-19" version="1">MASAEAKARHIVAEVIQRCSSEMVADTVVSVVPLPSNEMKGRVIGREGRNIRTFEQVTGVTVIIDDTPEIVLLSCFDPMRREVARQTLTDLVEDGRIHPISIERAHQRAVDRIEDMCLDAAADALSKAGIDDIDDRLLPILGSLRFRTSYGQQVLDHCVECARLAANLAAEIGADTEICRRAAFFYTISASPSLQVSREVVMLLLVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF75</accession>
    <name>W4TF75_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67182">
        <property type="protein sequence ID" value="GAE67182"/>
        <property type="gene ID" value="JCM18909_224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11682" checksum="F3F6312EF24A8D48" modified="2014-03-19" version="1">MDVVTRTLPPHEVSEANPWDTDRFWTVPNVLSVIRLIGVPIFLWLALGPRADGWAVAVLAVAGLTDWLDGRIARRWHQVSRIADARSGCRPSLHLCNRYCPDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFA4</accession>
    <name>W4TFA4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67113">
        <property type="protein sequence ID" value="GAE67113"/>
        <property type="gene ID" value="JCM18909_152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8198" checksum="74E8E98A57E35A23" modified="2014-03-19" version="1">MTDTKSSRHPWLHTASGLVGLVLALPVLVWSIAAVLPSHNTFTFVSSVLVGSLAVPTWSLPPLPLSSAFSVGELFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFL5</accession>
    <name>W4TFL5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-galactosidase fused to beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67566">
        <property type="protein sequence ID" value="GAE67566"/>
        <property type="gene ID" value="JCM18909_636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BetaGal_dom2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="174" mass="18243" checksum="F2C085FAE37306EC" modified="2014-03-19" version="1">MLHEFTGLSGGRHTLTVTNLGIPAQGGKGTIVSLDALRVTDDSAADAHGEKPSNPARQWARIPQDTSTTLHLHGRDALMMAADFPIGNHKVLYTTSQPFGAPVVTSGRGTVEYLVGHRGDPGETVLQFKAGSSAPTVRGSGVRTVWNATTGQLRLITPTPALRSISALVKATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFM0</accession>
    <name>W4TFM0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mobile element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67327">
        <property type="protein sequence ID" value="GAE67327"/>
        <property type="gene ID" value="JCM18909_374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9771" checksum="709A802E6FACC95C" modified="2014-03-19" version="1">MIIAELAAKDFNSAAHLASYAGLIPRTRQSGTSIKSETVSHTGNKRLKRALFLSAFASLHSDPVSRRYCDKKRLAGKRHNQALIALAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFR8</accession>
    <name>W4TFR8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67372">
        <property type="protein sequence ID" value="GAE67372"/>
        <property type="gene ID" value="JCM18909_422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="16441" checksum="ED3056434D77868B" modified="2014-03-19" version="1">MNLVEVAAAKPYRVRIGSGAVHELAGLVAGRRAAVVCPQTLVHLVPRFGIDDLVVIEVPDAEAAKTPEVLVDGWRRLAEANMTRGDIIVGFGGGATTDVAGFLAATWMRGIDVIHVPTTVLAMGDAAIGGKTGVNIPAGKKTLLEPSMSPSASCVTRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV8</accession>
    <name>W4TFV8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methionine ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67666">
        <property type="protein sequence ID" value="GAE67666"/>
        <property type="gene ID" value="JCM18909_741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8521" checksum="7747F99D23C6B1D0" modified="2014-03-19" version="1">MARRPSRSARLKQPTITGTSSRKKAAAEGINIDVVSFNDYTQPNVALSQGQIDLNAFQHLLFLADYDVKKITTTSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY9</accession>
    <name>W4TFY9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Activator of (R)-2-hydroxyglutaryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67348">
        <property type="protein sequence ID" value="GAE67348"/>
        <property type="gene ID" value="JCM18909_397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5939" checksum="575135A0453C3104" modified="2014-03-19" version="1">MWFVYNCLSAGDYNYQNFGTDKWSRHVKKSFPSLAHAVPEAGHRSIAQVHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG71</accession>
    <name>W4TG71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aconitate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67149">
        <property type="protein sequence ID" value="GAE67149"/>
        <property type="gene ID" value="JCM18909_190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14179" checksum="BD62CCD53195F3E6" modified="2014-03-19" version="1">MMRGTFANIRLRNQLAPGTEGGFTRDFTKADGPVTTVYDASVNYREQGIPLVVLGGKEYGSGSSRDWAAKGTQLLGVKAVIAESYERIHRSNLIGMGVLPLQFPEPISRFPRSDWRGNLRDYRCRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC3</accession>
    <name>W4TGC3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="6">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67582">
        <property type="protein sequence ID" value="GAE67582"/>
        <property type="gene ID" value="JCM18909_654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="7">
        <location>
            <begin position="123"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="253" mass="28003" checksum="EDBFFCA222213958" modified="2014-03-19" version="1">MQGELETWIPRVLRLDQPTPLTVAGRTDAGVHARGQVAHVDLPDNVDTSAMLRRLSRVLTPDVAVTSVRPVPSTFDARFSALWRRYVYRLWDESSRPDPVTRFHVAPVRGHLDLDRLNTAGTSLLGLRDFAAFCKHREGATTIRTLLDCHAERLDDPCGTVEVTVRADAFCHSMVRSLVGALTAVASGRRSQDWLDNVAASTSRASSVLVMPACGLTLEEVGYPSDEDLAQRAAQARSRRSHNDICDTCWEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD8</accession>
    <name>W4TGD8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67851">
        <property type="protein sequence ID" value="GAE67851"/>
        <property type="gene ID" value="JCM18909_941"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ_C" evidence="2">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8800" checksum="0423578C07B3B2AF" modified="2014-03-19" version="1">MEVPTLAGTTVRLRIPAGTPNGRTFRVRGRGVPRSDGSRGDLLATVEIAVPESLDDNARHAVERLRDSLRQATPRPWEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE8</accession>
    <name>W4TGE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nudix hydrolase family protein PA3470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67861">
        <property type="protein sequence ID" value="GAE67861"/>
        <property type="gene ID" value="JCM18909_952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14141" checksum="93E6D6D2D7337614" modified="2014-03-19" version="1">MRGRTCLNVRKKGADHVILPGGKIEPGETPLEAAIREAREETRLVLDPGDLTHLGTFDAPAANHDADGIRCAVYLCNWREIWPEPVPDSEIVEYEWTDLDHCYDDVRQAPLLCDRVIPALQQQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL2</accession>
    <name>W4TGL2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sialic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67558">
        <property type="protein sequence ID" value="GAE67558"/>
        <property type="gene ID" value="JCM18909_625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="268" mass="28557" checksum="9846E5E4BFBA30DA" modified="2014-03-19" version="1">MSLNITLVIAAMAGLLAIFALNILPFWGVLAVATVCGAIFVCLIVQFDPRRWVIGIGIMIVILSVFMYGWPILGLLPTYLTGAGYAASTVANLLTIAQFGNMIGYFVTGFMGDWIGMRKWYFTSILIAQIIVFPLFFAGIKSEWLIGLLLFFNQLFGQGVSGLAPRWVSSYFPVEQRAAGVGFIYNVGALGGAIGPFVGASLAKSHGLGSALGVLSVGFGLIVVLGVGLNLPRKLQALVNPEAVRPEDGDDRYINSGDLSSEFASSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN4</accession>
    <name>W4TGN4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67314">
        <property type="protein sequence ID" value="GAE67314"/>
        <property type="gene ID" value="JCM18909_361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="47" mass="5297" checksum="4BADFE3A33130E5F" modified="2014-03-19" version="1">MTDDSVYGPYSSGKGTLGKPKPGQQRPQPRMRMRERIVRWGTPKPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP2</accession>
    <name>W4TGP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67926">
        <property type="protein sequence ID" value="GAE67926"/>
        <property type="gene ID" value="JCM18909_1027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15657" checksum="6F35F331254A947B" modified="2014-03-19" version="1">MRRDGRSLGKRFDAKVRLPQAEPLVMGVFTGDAVDSAVLWGRKTFDAVVTDAPYGVVHGSHSGASRRRSPTDLLREAIPVWAGQLRHGGALGMSWNTLGLSREHLVTILSAAGLTPLDDDLWHQFSHRVDSSIHRDLIVAVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP4</accession>
    <name>W4TGP4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67324">
        <property type="protein sequence ID" value="GAE67324"/>
        <property type="gene ID" value="JCM18909_371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="194" mass="22145" checksum="916F1D51BE3BBA47" modified="2014-03-19" version="1">MGTGAIVTVMKLVGTRPIRTNRLVLRRWSVDHAQQMYDNWASDTEATRFVTWPPHPNVDATRSLLTGWVHDYDDPATFNWAVWLDDVIIGQIAVVNVDRRVNLAELGYCFGRRWWNHGYATETVKAVMSYLFDIAQVNKVEARHDPANIASGRVMEKAGMVTEGLRRACVIGSYGPRDSQYHGLLRSEWRGQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGQ7</accession>
    <name>W4TGQ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67717">
        <property type="protein sequence ID" value="GAE67717"/>
        <property type="gene ID" value="JCM18909_796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="234" mass="25625" checksum="615E2785959ED208" modified="2014-03-19" version="1">MLWRGRQPFFASGLTGFFYTQLLSPNAEEYNTAPIMEAVAIPGLSKIPFFGPIFFDQTVLVYIGFLCIPLVWFLLWRTTWGLRVRSVGEHPEAADTVGISVAGVRWSAVLVGGVFAGLGGAYFTIGTVGSFSKDITVDNGFIALAALIMGRWRPGLAAVMALFFQLRNPAVHRAVDDQRPNALAVPAYLAVHCDDRCCGWSGWQGEGTGLRWHPLHQGVTWTSIGTRYAVELTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW6</accession>
    <name>W4TGW6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68210">
        <property type="protein sequence ID" value="GAE68210"/>
        <property type="gene ID" value="JCM18909_1332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="151" mass="15840" checksum="B52402A37B8B2F84" modified="2014-03-19" version="1">MAQLIVEGLAAVMGAAWPVVAAMGGLAGFFFLPQIGTMARVRWRAMGAANPTMEAGILETSFAWEGAIDEASFALGPAAVGALAVLAGPVPGLIVAGACWWCWGVGLPWTRRRNSLRFIRAERFVPGPRLGQIVVAPARYSPPVSRLPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ5</accession>
    <name>W4TGZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptide ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67807">
        <property type="protein sequence ID" value="GAE67807"/>
        <property type="gene ID" value="JCM18909_892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="39"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="252" mass="27346" checksum="23052FF2CD5608B9" modified="2014-03-19" version="1">MPMPAHAWSKTSDSDKPGEKDRTPAGAKAIFKYLSAASENLQNYDTNKLWKTTLGPFQLGKYTPNGEAKLVANPSYDGEDKASISSFTMQPYTSDDAEFNILRSGSIDYGFIPPNSMTQQKYIEKQAIPSNRGTAGRSPTCRLTSTTRSPARYSPKNISVRRCNTSLIRKESPRSSGTGLHPPPAVRYPSNLAPPVAPKVAPTTTTLRKLRNSSKTTVGISLRTESPPVNKPGREKANAAKESSRGPSFPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC0</accession>
    <name>W4THC0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68186">
        <property type="protein sequence ID" value="GAE68186"/>
        <property type="gene ID" value="JCM18909_1307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="102"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24053" checksum="6605C40D86B18327" modified="2014-03-19" version="1">MKKDNHVNVVTNDQTFAADAVLVAAGRRPATEDLDLAAAGVATDERGYITVDDQLRTNIDGVYAVGDVNGGPQFTYISLDDNRVLWDTLHDGPRRRDDRVAVPTTTFLDPPLSQVGMTMRQARESGRSVLVATKDVATIAAMPRPKIVGQTEGLIRVLVDADDHTALGATLWCIDSQELVNLVSLAMRLGVRYETLRDGIWTHPSSTEAFNEVLGVLEPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH0</accession>
    <name>W4THH0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum site-determining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67942">
        <property type="protein sequence ID" value="GAE67942"/>
        <property type="gene ID" value="JCM18909_1044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="246" mass="25756" checksum="D82BC43700C42CA2" modified="2014-03-19" version="1">MMTLLRDLGWRFRDERGAATLEDLGMLPIMLLVVLAGWQILVVGVSDVMLGRAASAASREYAVTGSLALATDTARAGVPAPFNDVTVSGDSTINVKLRVPGSLTGVWGVMDVVETSKKCRGGISMSVYEPASRPKFRDDRGGAAIECIGLLPLFLVAAIATLQIGLAGWASIETEHAARDAARAASLGEDAQSAAEASLTGVLHVQSMSVVGGDSRRVSLTVKVPSLIGFRVGTVTRVAEMPRLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN7</accession>
    <name>W4THN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tryptophanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68450">
        <property type="protein sequence ID" value="GAE68450"/>
        <property type="gene ID" value="JCM18909_1588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="3618" checksum="2457527810CF52E3" modified="2014-03-19" version="1">MHLRLPPRGGVAACGTDNVMAALPGGVSSSPGAARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI23</accession>
    <name>W4TI23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68083">
        <property type="protein sequence ID" value="GAE68083"/>
        <property type="gene ID" value="JCM18909_1196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="285" mass="31614" checksum="DAD559AA0C5BBB88" modified="2014-03-19" version="1">MRAGLMLSTPFLVLFALFIAWPVFQSLLMSFTDMKIHDIRTPFAVNFVGFENYRKALADPVYQRSALNTVIFVAVGVPLTMAAGLASAIALNKGIKKFRTLFRVGFYTPVITSIVAVAVIWHFLLADNGAINQLLSWIGISGPHWLDDPSTALLSLILLSTWRNFGGSMIIFLAGLQNVPWTLHKAAMLDRAGPWKRFLHITFPQLKPTLLFVMVTTTIGYLQFFEEPFVMTKGGPLNATISASMYTYQQFGYGNYGVAGATAYLTFAVVAIATALQFHLTRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI51</accession>
    <name>W4TI51_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III epsilon subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68635">
        <property type="protein sequence ID" value="GAE68635"/>
        <property type="gene ID" value="JCM18909_1785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="319" mass="35228" checksum="421056EFDB69FC20" modified="2014-03-19" version="1">MRIATGVKAHECSTQLEAGVRELRLIDAHQPRYNRRSRRQRSVWWVTFTHEAHPRLAVVQRAHRDSQPPWGPFTSRQAATRAAIILAEAFGLRQCSGAMSRHPDGCPLAEMGRCSAPCLDPHIDYSAIVGFARLAMTGDVRDLTDRLAQHIARLSAAERFEEAAELTEDAQEVLRATRRRSRLVSLASCPEIVAARRDGASWEIHVIRHGRLAGAGRCRLGTDPMPVIDAVCATAETVSAPPAGLPACTIEETELVASWFEEPGVRLVDVIGEWSWPAHCWMDTNDLAARVAALHHPGHNESDEAHSQDRQARPQLAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIA8</accession>
    <name>W4TIA8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68267">
        <property type="protein sequence ID" value="GAE68267"/>
        <property type="gene ID" value="JCM18909_1391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13369" checksum="FEB0A4FD2A6E1320" modified="2014-03-19" version="1">MGACASSGGIFNNYAVVQGCDHIVPVDVYLPGCPPSPDMLIDAVFKIREQIQHWPLMGHMSEVEAAKEKQALDAKTTLEQKAHAMSDKPTPRAPQAARTPGIASPMAATSLIPAIPTRSTPPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ8</accession>
    <name>W4TIJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68606">
        <property type="protein sequence ID" value="GAE68606"/>
        <property type="gene ID" value="JCM18909_1753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="35"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="32258" checksum="FA5DE3C8C44312EA" modified="2014-03-19" version="1">MRPVSDITRRVAPFHVVSEFQPSGDQPQAIAELEKRVSSGEQDVVLLGATGTGKTATVAWLAEKLQRPMLVMQPNKTLAAQFAQELRTFFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKDSSLNEEVERLRHSATNSLLTRRDVIVVGTVSAIYGLGTPQEYVDRMIPLEVGQEWDRDELLRDLVTNQYVRNDISGERGTFRVRGDTLEIFPVYEENALRVEFFSATKLRPSRRCIRLRERSSARMSRSTCSRLPTMSPARNVWSGPSRPFSRSSRSAWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP2</accession>
    <name>W4TIP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-alpha-glucanotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68830">
        <property type="protein sequence ID" value="GAE68830"/>
        <property type="gene ID" value="JCM18909_1994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="24140" checksum="93141920797E47DC" modified="2014-03-19" version="1">MSLTDPHLTTLADHFGIARDYYDWKGQYTEVGEATVIAVLDGLGIDASTPERAERACHEVTNRKWRRVLPGIVVLREGHEGRVDVHVNAGEWVEVHVVCEDGQRRECWQVDNWNPDRYVDDRWIGEATFGIPGDLPLGYHTIVATTADHRATSTLVVSPNWLGLPRSMGSSRVWGHAVQLYSTRSRASWGMGDFFPTWRTCLPGRPPRVLTTYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS7</accession>
    <name>W4TIS7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68865">
        <property type="protein sequence ID" value="GAE68865"/>
        <property type="gene ID" value="JCM18909_2034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="6643" checksum="08165C6D2F662672" modified="2014-03-19" version="1">MGMSPAPGFTGDPDPPLGVGNGVGVTAGVGLPVGVGTTVGVGFGLGVGVGVGAGASPYWGRCSGRFGLSPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY2</accession>
    <name>W4TIY2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68114">
        <property type="protein sequence ID" value="GAE68114"/>
        <property type="gene ID" value="JCM18909_1230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="121"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="359" mass="38242" checksum="2E9AE9ACAB3B244E" modified="2014-03-19" version="1">MALLTGSMKAAGTRAALADIASGAAGIIVGTHSLLSGRVIYNDIGLVVVDEQHRFGVEQRSVLTTGEGARPHELVLTATPIPRTVAMTVFGDLEVSSLRELPTGRADVQTTVVDLPAHGSWLTRAWQRIREECDAGHQVFVVCPRINSDDADDVEGGRPPAAAIEELAPQLATGPLAGLRVEALYSRLDPSEKDLVMDRFIKGESQVLISTTVIEVGVDVPNATMMVIMDADRFGVSQLHQLRGRIGRGKLPGLCLLVTTAPPGSVACERLDAVAASRDGFELAELDLAQRHEGNVLGSSQAGYSSPLRLLRVLDHAEIVTASKDLAERWVAEAPDDPRLLDVVAATEMLAEGDLMEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY6</accession>
    <name>W4TIY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68751">
        <property type="protein sequence ID" value="GAE68751"/>
        <property type="gene ID" value="JCM18909_1907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="288" mass="31771" checksum="67B492A253D9EBC9" modified="2014-03-19" version="1">MWDQPGLATIQRRWRAIADEYADTPEGPRMFVAEAYLPHDRLVRYLEPDRLHTSFNFEFLISAWKANSLRTTITESLTAHESVGASATWVLGNHDNVRPVSRYGKEISGLDFSDPSAPHAQFHGTPTDVALGRCRARAAAMLELALPGGATFTKAKSLVSQRSKIFPKKPSKTPPGNVLVTQIAVVTDVAFPCRGAVPIHPMGGRQTRTPGSPCRVIGPSGPSNLNRTIRHPSLCPLPRPAGRAPCQPSAGRRNDDLERVQRRGSRLFPRAWFPVHRQLRRRKGGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ8</accession>
    <name>W4TIZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal protein L32p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68134">
        <property type="protein sequence ID" value="GAE68134"/>
        <property type="gene ID" value="JCM18909_1252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12772" checksum="918DC7459F2F277E" modified="2014-03-19" version="1">MGQMIRVQRTVPAPADLDVDMIGVPEDSPLELDLRLESVGEGILATGTVEATLEGECSRCLDPIKEELLLDVQELYFYPDKEADEDASRVSAEETIDLDPVVRAAVVLNLPFSAVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL4</accession>
    <name>W4TJL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68961">
        <property type="protein sequence ID" value="GAE68961"/>
        <property type="gene ID" value="JCM18909_2138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7544" checksum="DC12A799A12DE5D9" modified="2014-03-19" version="1">MAEIRKHKPSSSPIARALEAAMGESIKPVVPGSRPDKGVEEPETKLESTPSVAASPAQWGSFTVAMPPKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL6</accession>
    <name>W4TJL6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome d ubiquinol oxidase subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1468</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68339">
        <property type="protein sequence ID" value="GAE68339"/>
        <property type="gene ID" value="JCM18909_1468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="30637" checksum="CF4AEC7A865D1B02" modified="2014-03-19" version="1">MLPVLETTAHSPLTIVWFVLITVLWVGFFFLEGFDFGVAMLLPFLGRDDKDRRLMVNTIGPTWDGNEVWLLTAGGATFAAFPGWYATMFSGLYLPLLLVLLGLIVRGVAFEYRSKNPSSSWRNAFDWMATIGSFLPTLVLGVGFANFVRGLAVGPHSTPDGGTAPLVTTSFWGLFTPFALIGGILFVVLFCAHGANFVALKTMGDMHDRARKTSAKLGWIATIVALVWALMFNIMYVTRDGRQVFTWILCLLVVVLLAAGSAVVAKGREGLAFLCTALGIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM5</accession>
    <name>W4TJM5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="4">BPG-dependent PGAM</shortName>
            <shortName evidence="4">PGAM</shortName>
            <shortName evidence="4">Phosphoglyceromutase</shortName>
            <shortName evidence="4">dPGM</shortName>
            <ecNumber evidence="4 5">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gpmA</name>
        <name evidence="6" type="ORF">JCM18909_2154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="4 5"/>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68976">
        <property type="protein sequence ID" value="GAE68976"/>
        <property type="gene ID" value="JCM18909_2154"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="249" mass="28021" checksum="6327F2276E09796F" modified="2014-03-19" version="1">MTAKLILLRHGESEWNSKNLFTGWVDVDLNEKGEGEARHAADLLKQENLLPDIVHTSLLRRAIHTAYLALDGCDRHWIPVHRSWRLNERHYGALQGLNKAETKEKYGNDQFMAWRRSYDVRPPDLDRDSEFSQFHDPRYADIPESERPVAECLKDVVARMVPYFTSDIAADLKDGKTVLVAAHGNSLRALVKHLDEISDEDIAGLNIPTGIPLFYELDDNLKPVTKGGRYLDPEAAAAGAKAVANQGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV1</accession>
    <name>W4TJV1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JCM18909_1539</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68404">
        <property type="protein sequence ID" value="GAE68404"/>
        <property type="gene ID" value="JCM18909_1539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="54"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="205"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE68404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="300" mass="33247" checksum="719ABB82B2051EA1" modified="2014-03-19" version="1">MRHTLRETWSGLRRNAAMTLAVVVTMWVSLSLFGAALLATQQVDLLKGKWYDKVEVSVFLCVDGVPGAQCSGEKAATQAQKDAIREALESNPQVSRVYYESKHEAFEEYQRIYADSPVRDVLTEDTIQDSYRVKLIDPQQYQGVVTEAQSLPGVQSVVDLHNVLDPIFLWMNALRWVTFGMSVLLLVAAALQIGNTIRMAAFSRRRELGIMKLVGASNTYILMPFLLESLIAGLLGALLACVTLALGADVVVMRKMAHSITTLAWVGWPQVWKSIAWMVVVAVVLSVAPAYVATKKYLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY4</accession>
    <name>W4TJY4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside 5-triphosphatase RdgB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68847">
        <property type="protein sequence ID" value="GAE68847"/>
        <property type="gene ID" value="JCM18909_2012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10469" checksum="EE937B5D14AC3CA7" modified="2014-03-19" version="1">MSRIVLASNNAKKLVELRRTFEGAGTEVEIVGLSEVSDAPAPEETGRTFVENASSRLVLRPAKPVYLLWLTTPDSRLTPQPDARYPFGTLVRASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF1</accession>
    <name>W4TKF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69276">
        <property type="protein sequence ID" value="GAE69276"/>
        <property type="gene ID" value="JCM18909_2476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5874" checksum="93FE85C9F4DBC03D" modified="2014-03-19" version="1">MVVDRGDGWHTAWLEVDRNDMGDVMADFADPCETLGFGHGGQVTAITKRLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH6</accession>
    <name>W4TKH6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68664">
        <property type="protein sequence ID" value="GAE68664"/>
        <property type="gene ID" value="JCM18909_1815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="4970" checksum="AD0E81BA387FC7E3" modified="2014-03-19" version="1">MPTSLIDSQYATLEPLAADEAGITLNFDATREELTTKAATWLADVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK5</accession>
    <name>W4TKK5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sorbitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69475">
        <property type="protein sequence ID" value="GAE69475"/>
        <property type="gene ID" value="JCM18909_2694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="12909" checksum="303A70E696128A4C" modified="2014-03-19" version="1">MKALRFHAPEDVRLEDVPEPECKPDEIKIKVRNCSTCGTDVKILHNGHQNITGVTTMGHEVAGEIVEIGSEVAGDWKVGDRVQSIAAVPCGQCTSAARGGCRSAKTRPASVISTTVVLRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK8</accession>
    <name>W4TKK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69062">
        <property type="protein sequence ID" value="GAE69062"/>
        <property type="gene ID" value="JCM18909_2245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="198" mass="21361" checksum="EAF63613732996F9" modified="2014-03-19" version="1">MARRLFADNGMAGTSVEEIAATAGVSKPVIYEHFGSKDGLYAVVVDREVRHLQDSLNAAMTRPKQGPKRTLESAVLALLDYIDDRPDGFRIISRDSSVGSATGSYASILSDVASWAEGILAANFDRHGFDVSYSYLYAQALTGMVGMTGQAWLDTREPAKEIVAAHLVDLTFNGLAHLSGSPHLSRHTERESLQSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT0</accession>
    <name>W4TKT0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69555">
        <property type="protein sequence ID" value="GAE69555"/>
        <property type="gene ID" value="JCM18909_2784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="5769" checksum="614168C5ED0DD1BF" modified="2014-03-19" version="1">MAGSCLNGGTALAAPLIGAIMDANGWQWGFLVAGIAGAVIGATVWTAERVVRKRQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL05</accession>
    <name>W4TL05_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69650">
        <property type="protein sequence ID" value="GAE69650"/>
        <property type="gene ID" value="JCM18909_2895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="37"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="132" mass="13312" checksum="17B7308A60CBAAA2" modified="2014-03-19" version="1">MKFIDWFADGSVYVVDLALACCGVESGAAVSANAPVRDEIPDGAPIVVLVSGTVTTGLAPVVRDTVHELKRNHPVDVVAFGACACAGGPYWDSAGVVAGLPDAGVDADHWIPGCPPGPETLTGLLASSQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL30</accession>
    <name>W4TL30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69431">
        <property type="protein sequence ID" value="GAE69431"/>
        <property type="gene ID" value="JCM18909_2643"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7899" checksum="22FDA4922CBD4559" modified="2014-03-19" version="1">MIGIQPHKHDELMAALASRFTVVSHEEVRADVSLDEAAASDAVAMGPSTHHVREVHVEAMSVTSAVEVTVLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL35</accession>
    <name>W4TL35_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69436">
        <property type="protein sequence ID" value="GAE69436"/>
        <property type="gene ID" value="JCM18909_2650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13501" checksum="0520656BF95E457E" modified="2014-03-19" version="1">MGIPPRPKKSRVKKTSGPRSAGAHGMFTWGALGMATNFTTIPLFISSSQRIGTADLPLVVRILTLIISWWIVLIPAWLPVVIDRLRPNSSGISGRTRERISHWTSVASIIACLGSGIIIVWTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL86</accession>
    <name>W4TL86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69740">
        <property type="protein sequence ID" value="GAE69740"/>
        <property type="gene ID" value="JCM18909_2989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="132"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="395" mass="42986" checksum="6A702F94E151C612" modified="2014-03-19" version="1">MIRIAIIGAGRIGHVHARAIQGRNDVTLALVCDPFEQNACALAGEYDVRYCLDPDEVFDDSTIDAVVIGSPTQFHVDHILKAVNSGKRVMCEKPIALDVESAKRCINELGDRADQVMMGFNRRFDPTFSALKSRLDDGEIGSLQQLTVISRDPAAPSASYIAGSGGIFKDMTIHDFDMVRHFLGDIAEVNAVGTNVSPEIAEQGDFDQVIVTLKSRDGKLATIINSRTCAFGYDQRLEALGAGGMLSADNLTNTAVRMATSTQTDAKTAIMDFFSLNVTKTPTASSWKPSLTRSPSAARFLRRCVTAMRPLSWPMQLRVVPRSIASSPCDATRYDHGVSTDNQCSTVRRPRTLNPSKCRHNTALLTCPLAPLVPANALLSNSSPEPEHFIRCCHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB0</accession>
    <name>W4TLB0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine adenosyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">JCM18909_2422</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69228">
        <property type="protein sequence ID" value="GAE69228"/>
        <property type="gene ID" value="JCM18909_2422"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="71"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GAE69228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="240" mass="25803" checksum="29A1300C5EB4C345" modified="2014-03-19" version="1">MWRGHYRAYVDIAGIARSRILDIGYDSSSKGFDGASCGVSVAIDAQSPDIAQGVTAAYETRHGSTDLIDSQGAGDQGLMFGYACTETPSLMPLPIDMAHALSLQLTKVRKEGALDYLCPDGKTQVTIRYNEDDRPVAVDTVIVSSQHRAGIDLDATMTPDLRRLVIDPVLERYDLDHKDMRVLVNPTGKFVIGGPMGDAGLTGRKIIVDTYGGMARHGEVPSPAKIRPRSTVPGPMRCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD9</accession>
    <name>W4TLD9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69337">
        <property type="protein sequence ID" value="GAE69337"/>
        <property type="gene ID" value="JCM18909_2541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7269" checksum="6220B36414689E5B" modified="2014-03-19" version="1">MPGQRIVTMEIGLDAPLCAEPAGLEGLAGLVVRTADESTGPHPGAAFAEAMESIGASYDGSAGLAGSHVASMCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE9</accession>
    <name>W4TLE9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69347">
        <property type="protein sequence ID" value="GAE69347"/>
        <property type="gene ID" value="JCM18909_2553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="22681" checksum="8E34E7D586CBB963" modified="2014-03-19" version="1">MTSTGAVDSMHDSFTAIGGMFTLLNMMLGEISPGGVGSGLYGMLVIAVIAVFIAGLLVGRTPEYLGKKIGSREMKLSALYILVMPSLVLCGVALSLAVPGLRSSVNTSISNPGEHGLSELVYAFTSAANNNGSAFAGLDASTNWLCAALGAAMLLGRFVPIILILALSGALVEREPVPVTAGTLPTHNALFTTLIVFTAILVTALVFFPVLTLGPLAEGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG7</accession>
    <name>W4TLG7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T2SSF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69825">
        <property type="protein sequence ID" value="GAE69825"/>
        <property type="gene ID" value="JCM18909_3081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="7">
        <location>
            <begin position="108"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="264" mass="27842" checksum="B316A70BA719AC38" modified="2014-03-19" version="1">MNTAIAALLGGLLVGGVVMVGIGIAPIHQLSTGQSTSLWTRVDNWFSRLPRRSRVHGLTGLGVGVVGYVVTGWAVVLVIVPVLAVVVPTLLADPPRHDLDVMRALERWVRLVSGSASTGKSVIDAIRATRRQAPELLLEPLTRVVARLDSRWDIRAALQGLADDLDSADADQVIAAIMMAAERGGTGATCTLDALAASLQERIRAAREIRVERAKPRVVVRQVSIIIGVVLAGASSLAGNIWFHIAPASASCCCAATQVFTSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG8</accession>
    <name>W4TLG8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron(III) dicitrate transport system permease protein FecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69362">
        <property type="protein sequence ID" value="GAE69362"/>
        <property type="gene ID" value="JCM18909_2570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14584" checksum="7A560B65E2E1EF09" modified="2014-03-19" version="1">MTTTQRQRGLPLPVRFTILGVIFVLVALAGLALGSVNIPLGDIMTVITGGSNVDPVSLTIIHDVREPRTITALLVGAALGMSGLEMQTLFRNPLADPYVLGISSGASLGVAWWCCPPRHRRVRRPSPPDWASDRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH4</accession>
    <name>W4TLH4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-tyrosyl-tRNA deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69004">
        <property type="protein sequence ID" value="GAE69004"/>
        <property type="gene ID" value="JCM18909_2183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="4921" checksum="9C5F0557A4545037" modified="2014-03-19" version="1">MDHFVTHLRSLGAHVETGIFGADMKVGLVNDNPMTILIDTDDWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN7</accession>
    <name>W4TLN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ketol-acid reductoisomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69900">
        <property type="protein sequence ID" value="GAE69900"/>
        <property type="gene ID" value="JCM18909_3166"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="7">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="8">
        <location>
            <begin position="183"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="29906" checksum="355461E22CD558AA" modified="2014-03-19" version="1">MAKIYYDDDADLSIIQNRQVAVIGYGSQGHAHALNLRDSGVDVRVGLREGSSSIAKAEAQGLRVLSIEDACEEADVIMVLVPDQNQRQLYAEHIAPHLKDGDALFFAHGFNVHFGYIKAPQGVDVCMVAPKGPGHIVHREYSDGRGVPVLVCVEQDASGIAWDLTRSYAKALGGLRAGGIETSFREETETDLFGEQAVLCGGLSHLIQAGFETLVTAGYQPEMAYFEVCHEMKMIVDLIIEGGISKLRSSISDTAEYGDYVSGPRVIDDHVKKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP9</accession>
    <name>W4TLP9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69104">
        <property type="protein sequence ID" value="GAE69104"/>
        <property type="gene ID" value="JCM18909_2291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6177" checksum="632BF902C15868BE" modified="2014-03-19" version="1">MGKKVTIKAGSLDEVDKRVAQALGNKSGSLKITPRTGEAERPEQWDNSVIRDPAVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLQ6</accession>
    <name>W4TLQ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2',3'-cyclic-nucleotide 2'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69114">
        <property type="protein sequence ID" value="GAE69114"/>
        <property type="gene ID" value="JCM18909_2302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5_nucleotid_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="27829" checksum="CA8079ABB90C96B1" modified="2014-03-19" version="1">MVEDTPILDFIGKVEADTVAKAIKGGRYDGIPVIAQVSPFSRTAAFPKGDVKIKDIAGLYVFDNTLAGILLTGKQLKDYLEYSAKYFKQVKKGAAVNPAPASEGGDTQADYQGKPVWDYNYDAVTGVTYSIDISRPVGARILGLSWQGKPVAHDQKFVLAINNYRMSGGGGYPHVAEAPVVWDEILEIRQLLIDTAMAMKTIDPKDFFSIATGSSPQPARRGQAVASQVTAAHLVGPNRDLALPIVRRPCQALASDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM68</accession>
    <name>W4TM68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69826">
        <property type="protein sequence ID" value="GAE69826"/>
        <property type="gene ID" value="JCM18909_3082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17475" checksum="82B3523E65FFA501" modified="2014-03-19" version="1">MPGRVHRRDLIPEALRQNLSRLVVGEVRGVEAAAMFEAMQAGAGTMSTTHSHSATSTMDRLAGRVAMGGVMTIEEAYRQIAHNITFLVHVTLVDDTWRGGTRTRHITEIRQLTGALENGRPVTHLTYAAPTPTSPGVFHPDPTLVAELSHYEPEVTRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM75</accession>
    <name>W4TM75_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69294">
        <property type="protein sequence ID" value="GAE69294"/>
        <property type="gene ID" value="JCM18909_2494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF_alpha" evidence="1">
        <location>
            <begin position="117"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="24115" checksum="CEEAF6C68D78D6F0" modified="2014-03-19" version="1">MPVEAVAGFAAEQVAAEPGDVVLAGTSSVDRVLVAAVAVQLDAPIYRGLQELEADKATVLQLGGVLEQTLSLSTPIVFVCEPGGPSEGPCPELTQVSATVDGATVVSSDKVGSQATNLAAAKRIVACGRGFREEADLHIAHDLAAQIGAELACSRPLAEGVSWFEKKLYVGISGAQVSPELYIAVGISGQLQHVVGMNKSQTVVAINSDPDAPIFLSRLIMELSETSMQCFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM96</accession>
    <name>W4TM96_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70105">
        <property type="protein sequence ID" value="GAE70105"/>
        <property type="gene ID" value="JCM18909_3396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="38"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23006" checksum="2D6AB6B5A68956DA" modified="2014-03-19" version="1">MVVSTCIAAFVALLGPWALAGALSYGKVHDVADTEPRDVAIVLGAQVLPSGTPSAYLRGRLDVAADLYRSGKAKVILVSGDHRETHYNEPKVMKTYLVSKGVPAARIVEDVAGLDTYDTCVRARRIFGVDRAIMVTQDYHEIRTVATCRMTGLDAVGVPDRGQPRDDVWWYGWGREFGSRLKMIWDVVSRREPTLGETDDGVREALNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC8</accession>
    <name>W4TMC8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69563">
        <property type="protein sequence ID" value="GAE69563"/>
        <property type="gene ID" value="JCM18909_2796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="147"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="400" mass="44097" checksum="ADE2608DF51FEC12" modified="2014-03-19" version="1">MMEKRRTIGVGVVSLGWMGRLHTRAYKALAEKFPEIDVNIRLVSCCDVVAENRRQAVDRLGFCTVVEDYHDLIGNPEVDVVSICAPNFLHRDIALAAAEVGKPFWIEKPMGTNAKQSRQIAEAAEAKGLVTSVGFNYRHTPSIEFARQLIADGRLGTVTNARAWLIADYASDLHGPLTWRYDRERAGAGVILDLMGHGEDLVQYLLKGRFTEVSAVSETFIRQRPKPLKEGIGHTGWVVSDELGPVGNEDYCAVIARMENGVMCTLESSRVSVGPRAEYIVEIYGTDGLIRWNFEDLNHLQVCLGRNNRALQGYVNCMAGPDFPEFMRFQPGAGTSMGFDDMKVVEAAKFVRGVLDGQQYGPSVADGWASAEVNDAIVASCGDHAWHDVKPVSGRTTFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF3</accession>
    <name>W4TMF3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69717">
        <property type="protein sequence ID" value="GAE69717"/>
        <property type="gene ID" value="JCM18909_2966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9074" checksum="FD07045B09004CDE" modified="2014-03-19" version="1">MACRLRLDDGVHRRRPSATAGHGMFPDATRVYITIAATIVGLFLTGLGSALASGSGKTRPVARNIIVGMCSMAITYLIGHFVGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG0</accession>
    <name>W4TMG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70170">
        <property type="protein sequence ID" value="GAE70170"/>
        <property type="gene ID" value="JCM18909_3467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8015" checksum="7EAB69BE1F5BBCF2" modified="2014-03-19" version="1">MLRGKWIVCGHDDAHLVVVCEVSQQLEEPFGRRGVERPSRFVGKEDVLPAGQCSRNSDALPLATRDLAGVASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH4</accession>
    <name>W4TMH4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-threonine 3-O-phosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69618">
        <property type="protein sequence ID" value="GAE69618"/>
        <property type="gene ID" value="JCM18909_2856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="40" mass="4526" checksum="A60B50245656EB60" modified="2014-03-19" version="1">MRRGETFPGLGPTWIRLAVRDLNIHAELARALSDLTAHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI2</accession>
    <name>W4TMI2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Substrate-specific component CbiM of cobalt ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_2867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69628">
        <property type="protein sequence ID" value="GAE69628"/>
        <property type="gene ID" value="JCM18909_2867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018024">
        <property type="entry name" value="CbiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43627">
        <property type="entry name" value="PTHR43627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE69628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="13423" checksum="949DE8E5986D0A75" modified="2014-03-19" version="1">MLSAIKLPSVTGSSSHPTGTGVGAALFKPPVMAFLGMIVLIFQALLLAHGGISTLGANTFSMAIAGPWAGYAFYKLTKKLRGPDALAIFLCMVFSDFITYVVTSFQLAFASRMPPVASGELSASSSASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ1</accession>
    <name>W4TMJ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoserine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69762">
        <property type="protein sequence ID" value="GAE69762"/>
        <property type="gene ID" value="JCM18909_3013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="1">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9535" checksum="AC635287B4BBCF29" modified="2014-03-19" version="1">MAHNETSTGVVAPVRRPNDIDDNSLVLVDATSAAGGVAADMSTIDAYYFSPQKKNLSSDGGLWLAILSPAAIERSNRVTSSARWVPRCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ7</accession>
    <name>W4TMJ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69648">
        <property type="protein sequence ID" value="GAE69648"/>
        <property type="gene ID" value="JCM18909_2892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="40"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="280" mass="29739" checksum="3175B49D0EBBC10D" modified="2014-03-19" version="1">MRYEVAPAPMPEGTYRQVTGNLATAYGLITGANRAGLQLFLGSYPITPASDILHELSKRKAHNVVTFQAEDEIAGVSSAIGASFSGSLGVTTTSGPGMSLKSEAIGLAVMTELPLVVVDVQRAGPSTGMPTKPEQADLLQAMFGRNGESPVPVLAAKSPSDCFDTALEACRIAVTYRTPVIMLSDGYLGNGAEPWKVPDLAEIPRIDPHFATKPNTTAADGSPRFMPYRRDPQTLARPWALPSTKGLEHRVGGLEKSAHTGAISYDPANHEEMVATRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN0</accession>
    <name>W4TMN0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70245">
        <property type="protein sequence ID" value="GAE70245"/>
        <property type="gene ID" value="JCM18909_3544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5936" checksum="86F4301C36FA4DFC" modified="2014-03-19" version="1">MRSGNWQASYSDPYGAKDAKGRTRQHKAPTTFIAHDDAVTWLKGEEKLISWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU1</accession>
    <name>W4TMU1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA large subunit methyltransferase N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69857">
        <property type="protein sequence ID" value="GAE69857"/>
        <property type="gene ID" value="JCM18909_3116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13093" checksum="63AF9D59E121E995" modified="2014-03-19" version="1">MTKVSQQSCDRGTTVKTLWRLHGGALVESVLMYYPATRHSAARTTLCLSSQAGCGMACPFCATGQGGIQRNMSTAEIVSQVLAANRLIAAGEVPGASGRVHNIVFMGMGEPMANYRSVLTAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN09</accession>
    <name>W4TN09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70111">
        <property type="protein sequence ID" value="GAE70111"/>
        <property type="gene ID" value="JCM18909_3402"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8306" checksum="4254B4D8DA3EEF27" modified="2014-03-19" version="1">MLMIGLELIDADGSENVAATNHIAKMARKYGLLMRTSRYGRGNVLKIRPALNITLDEAETMCDRLEQLIRGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN86</accession>
    <name>W4TN86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70201">
        <property type="protein sequence ID" value="GAE70201"/>
        <property type="gene ID" value="JCM18909_3499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="281" mass="29265" checksum="5EF457E4BC342531" modified="2014-03-19" version="1">MPTSSAGSHRAWLMVGAGVSLLAGLDGALLLLSVWSPVMSTRLSEWHGPLMVLGFVGTVICLERAVALGHRLAYLVPAVSGLGVIVLLAPLPFDSARAGLALLTLAQLGLLTIYVPLWRRSHDDAVVIQGAGAFCAAGAAALLATGAHVSQIVGWLACYMMLTICGERLELSRLTMARNRALPTLCLAVVAALLVSVVSPAIGWRVLGVVLIGLAVWLCRHDVARGGLGRGSQAAYIGILLMVGYLWLATAGTVCTVQGPPISRSGYDAVVHSLFSDSPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB0</accession>
    <name>W4TNB0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease protein DppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70435">
        <property type="protein sequence ID" value="GAE70435"/>
        <property type="gene ID" value="JCM18909_3753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="303" mass="32299" checksum="863E5B48FBA3341F" modified="2014-03-19" version="1">MSFFALLSLLPGDVAQVILGANADPKAAATVRSRLGLDLPWPQRYWDWISSLVRGDLGTSIVSAEPIGPQIASRLAVTGWLVGLSLVLALLVCLPVGAYAAVHRRKGRGFAASALSQVLMSIPAFLAGILLILLFSVTLGWLPAGGYVPLHEDAGAWAAHLILPVLSLSIVQAAVMTRYVRSAFIDVLADDHMQTARAVGWRLWPALHRHGLRNASISLATVLGLQASAMLVGAIVVEEVFVIPGLGSYLLDAVSTRDLLVVSDVVMVIVAIVMAISYLTDLIVVVLDPRLRTTIRAAQEEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND2</accession>
    <name>W4TND2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69724">
        <property type="protein sequence ID" value="GAE69724"/>
        <property type="gene ID" value="JCM18909_2973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17491" checksum="60E9A3D5CDF4917F" modified="2014-03-19" version="1">MILSEDAASAKKLAAYRDDPDKICAVCVRLITEGVDVPDAAVLIYSTTASTPLFFAQMVGRVVRARNRRERATVFLPAVGRLLDLASQMEEVRDHVIGPPAEPDLIEEFDTRERSEPDPDAGTWQAVASDAILGEVIDTYVPSDGGLFALDGLISLSRSGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG7</accession>
    <name>W4TNG7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CTP synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69928">
        <property type="protein sequence ID" value="GAE69928"/>
        <property type="gene ID" value="JCM18909_3196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="5875" checksum="A55E6C49C813C51E" modified="2014-03-19" version="1">MGTDNHCSKHVFVTGGVVSSLGKGLTASSLGSLLKARGLKVTMQKLDLTSTSIRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ3</accession>
    <name>W4TNJ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP synthase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69958">
        <property type="protein sequence ID" value="GAE69958"/>
        <property type="gene ID" value="JCM18909_3231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016469">
        <property type="term" value="C:proton-transporting two-sector ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="5">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17159" checksum="51216DFE31881543" modified="2014-03-19" version="1">MAELTIRPEEIRDALDNFVQNYEPETAVREEVGTVVTSGDGIAHVEGLPSAMANELLRFENGTMGIALNLEERQIGVVVLGDSDGIDEGSTVRGTGEVLSVPVGEGYLGRVVDAMGNPVDGLGEIKGVEGRRALEIQAAGVMDRQEVRERCRLVLKPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ7</accession>
    <name>W4TNJ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69784">
        <property type="protein sequence ID" value="GAE69784"/>
        <property type="gene ID" value="JCM18909_3036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16930" checksum="67F81FD14F72A7F2" modified="2014-03-19" version="1">MDQERRPMSPEQVTEAVTCSFDDELDQFAAVFTILGSLHYQVPDADHLHELLQMIDEWPLSRPQSPSRMKEGLQMWRLSREEAESRQDVVADHDRLYGDSAVALVPPYESVHRNREGLSSTNTLYKCVPPTPVSGLPHLISTANLTITSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN4</accession>
    <name>W4TNN4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69819">
        <property type="protein sequence ID" value="GAE69819"/>
        <property type="gene ID" value="JCM18909_3074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5290" checksum="62F0C7DCF60873F6" modified="2014-03-19" version="1">MMTLAGGHSDGLGNDADTEYGPGPQPITVTTVRKIDRHQGLAILLGATRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT0</accession>
    <name>W4TNT0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_3974</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70620">
        <property type="protein sequence ID" value="GAE70620"/>
        <property type="gene ID" value="JCM18909_3974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE70620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="534" mass="58228" checksum="023305183F8DDE35" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT4</accession>
    <name>W4TNT4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Secreted lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70625">
        <property type="protein sequence ID" value="GAE70625"/>
        <property type="gene ID" value="JCM18909_3981"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850838" evidence="5">
        <location>
            <begin position="27"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="7">
        <location>
            <begin position="65"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="249"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="404" mass="43481" checksum="99FEC67A7C1F6C27" modified="2014-03-19" version="1">MPSKLTRRSVLATGAVALPMTAAACAKSSVGENGFGSSGNSATPTPTPTPTPATLTITADHPITELQPGDALKFAVANGTLKDVKVTDSEGSEVTGTLKDTVWTPSKPWSLKTSYTVTATLSNTDPHAGPTTTVTKDIKSIDGAVNVVEMLYDDASVGIGMPVIIKFGHEVIDADMRARIQKAMHIDVSPQQEGAWGWIDHSQLMWRPKDFWKAGTKVNVSGNLTGLPTSSHRWITHDVKGSFQVGQARIIKIYINKHKMDVLQNGKVVRTIPVTTGKPGASTTTRSGTKVIIERDATRIMDSSTVGIPKGSSDYYHLKVKYAMRVTYTGEFIHAAPWSERSQGSANVSHGCVGLSTENARWLFNFCAAGDPVINSGSNRMFKPDEGIGCWCYDWSGWQKLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP07</accession>
    <name>W4TP07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70441">
        <property type="protein sequence ID" value="GAE70441"/>
        <property type="gene ID" value="JCM18909_3760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="15038" checksum="6492B7712AF45E9D" modified="2014-03-19" version="1">MNWALLTPVTNPTHKLVLVALANFADDDDLAWPRVDTLSQLTSSSRRTVFRALDALVGAGLIERLAGFERADRGGLHRAQSVWRYGCPIVSRDVRVTVIVVLEWFVNPLVKSTLTLVIYFSTPLYLVEVCSLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP94</accession>
    <name>W4TP94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein Jag</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70536">
        <property type="protein sequence ID" value="GAE70536"/>
        <property type="gene ID" value="JCM18909_3875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="4">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="200" mass="21786" checksum="56AEE13799A08C59" modified="2014-03-19" version="1">MSESSECSEEFDVDQVEDRGNLESEEIEVDDVESEDSDGNDGDDAENDDEDAGDPLDEEGDIAADYLEELLDIADLDGDIDTYVESGRAHVSIVTDSQTLVGKDGKVLEALQELSRLAVMTEVGHRSRLMLDIAGYRESRRKDLVVLATEAIQSVKETGEPAHLAPMNPFERKIVHDAVAAAGLVSESEGVEPKRHVVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPC1</accession>
    <name>W4TPC1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70049">
        <property type="protein sequence ID" value="GAE70049"/>
        <property type="gene ID" value="JCM18909_3333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849351" description="Mannose-6-phosphate isomerase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="323" mass="34481" checksum="7BBD8E130A258662" modified="2014-03-19" version="1">MTVCLFLLKILSANHALSIQAHPSREQAEKGFAAENEAGVPLDAPNRLFRDDWPKPEMIVALTDFDALCGFRDPSSSLVLLSGLGEVDGLNEVLTPLSQNDGLVTLVAAVLSGDDDMTPVVKRVVSASRAYLNDGADEDVRSLATTAVELWEDHPGDPSILVALLMNRVRLAPGQQIHLCAGSMHAYLGGTGVEIMANSDNVLRGGLTSKYIDVKALLDHANMTPEPCFGEYAQQISPGVGVYHTTFPEFRLWGLEGHNDVIDLPAAELGRILLVTEGQLVAHCGTDDCELSRGQSVWLPAQDEVKVTGQGRGFLASAGVGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPF4</accession>
    <name>W4TPF4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70293">
        <property type="protein sequence ID" value="GAE70293"/>
        <property type="gene ID" value="JCM18909_3601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="39"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="465" mass="50747" checksum="15ECE25F29ECC5EB" modified="2014-03-19" version="1">MTFPSSMRPLTSREVFVSVRPEGSERAHSPIPEAPEGRRTYVIDTSVLLSDPRALLNFAEHEVVVPIVVITELEGKRHHPELGHFARAALRILDRLRLENGGLVGPVPVNDEGGVLLVELNHSDPLCLPDGFRLGDNDTRILAVAQNYRLAGHSVVLVTKDLPLRVKASAIGLEAEEYRHELVPSSGWTGMVNLEVPDEMISTLYEEGSVVDSIFDEIPVHAGLVLEGPNGTALARRMPDASARLVPNDQEAFGIRGRSAEQRIALDMLLDPQVGIVSMGGRAGTGKSALALCAGLEAVMERQLHKKVMVFRPLYAVGGQDLGYLPGDEGDKMAPWGQAVLDTLTSVTNNYVIEEVMSRGMLEILPLTHIRGRSLHDAFVIVDEAQSLERNVLLTVLSRIGQNSRVVLTHDVAQRDNLRVGRYDGVAAVVERLRGHDLFGHVTLTRSERSPIAALVTSMMEDMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK5</accession>
    <name>W4TPK5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70144">
        <property type="protein sequence ID" value="GAE70144"/>
        <property type="gene ID" value="JCM18909_3440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12612" checksum="D42FB3D6A7644225" modified="2014-03-19" version="1">MNWMYPEITDIVREMIRLRYRLIPFLYTLSYLAAERREPIVNPVFSLDDTLLEESDDFLLGHDLLVASVVEKKGQTTRTVTLPHVSDGWFEFDTGVHHDPGTVSPSRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPL8</accession>
    <name>W4TPL8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70452">
        <property type="protein sequence ID" value="GAE70452"/>
        <property type="gene ID" value="JCM18909_3778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="23525" checksum="EE7C37890F43D3A0" modified="2014-03-19" version="1">MTRALDHIDIAIPAGQSVAVMGPSGSGKTTLLHCLSGVLSPDSGSIELALPDRTVNVENLSNEGRAKLRRQSLGFVFQQGMLVPELTAVENTALPLMLNGVSRTDAVRYATQWLKSMGLGCMEDRRIGQLSGGQAQRVAIARSQVIDPSIVFADEPTGALDSATAVEVMAILLSATTGRGRTLVVVTHDEDVARRCQRILHLHDGRIVSDHVRHSDGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM2</accession>
    <name>W4TPM2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-mannonate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000065">
        <property type="protein sequence ID" value="GAE70686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70686">
        <property type="protein sequence ID" value="GAE70686"/>
        <property type="gene ID" value="JCM18909_4062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="16235" checksum="30A4A78228FC8E02" modified="2014-03-19" version="1">MREVEEERFPTPFLGDTPSRIATDTSQKIPIRFGETVKSYLADDSLDVASLRAIPFVFAVWCRYLMGIADDGEPVELSPDPLREQLESVVSGVRFGDDDSKVISPILSRADIFGIDLTMTPLSEVVERFFYPPDSRSRFRKVGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPQ8</accession>
    <name>W4TPQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000091">
        <property type="protein sequence ID" value="GAE70721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70721">
        <property type="protein sequence ID" value="GAE70721"/>
        <property type="gene ID" value="JCM18909_4109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6222" checksum="2D84ED2415FAF46E" modified="2014-03-19" version="1">MIRQLRGRGAARFGSYPTVSTAAMTLALVSGRTSGLSLSARGDGLSRRRRMLWRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ51</accession>
    <name>W4TQ51_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_4042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000063">
        <property type="protein sequence ID" value="GAE70667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70667">
        <property type="protein sequence ID" value="GAE70667"/>
        <property type="gene ID" value="JCM18909_4042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="136"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="447"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="776" mass="86914" checksum="307147E1122FFD89" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ72</accession>
    <name>W4TQ72_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_3877</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70538">
        <property type="protein sequence ID" value="GAE70538"/>
        <property type="gene ID" value="JCM18909_3877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE70538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18987" checksum="A75E7DF9BCBF12FA" modified="2014-03-19" version="1">MLNPLVILGLGGALHTMGHAIMVPLYWAVSGLLVLFHYLWSPLFGRDSGISWTLAIVCLTIFIRLLLVPLFVKQINSVRSMQLIQPKMKAIQEKYGDDRERAGQEMMNLYREEGVNPAASCLPVLLQMPIFLALFRVLDGASRGIPRGHFFAKKSRADGIPATRQVLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ92</accession>
    <name>W4TQ92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000076">
        <property type="protein sequence ID" value="GAE70712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70712">
        <property type="protein sequence ID" value="GAE70712"/>
        <property type="gene ID" value="JCM18909_4095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="5096" checksum="5D496BDB9E8EA8F5" modified="2014-03-19" version="1">MIYAVNLERMLATNPDLVIAPGAVSQNVTDKLSSQGIPVLNIKNEVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQB1</accession>
    <name>W4TQB1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosylamine-glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70404">
        <property type="protein sequence ID" value="GAE70404"/>
        <property type="gene ID" value="JCM18909_3722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GARS_A" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="8896" checksum="BCA307FADBA6ECB1" modified="2014-03-19" version="1">MAAARVPTAASRSCDDVNSVSAALDEFGPPYVVKDDGLAGGKGVVVTHDRAEALAHAERCFESGHRVVVEEYLDGPEVSLFCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQC0</accession>
    <name>W4TQC0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Collagen alpha 1(I) chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70598">
        <property type="protein sequence ID" value="GAE70598"/>
        <property type="gene ID" value="JCM18909_3948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0176">Collagen</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16915" checksum="903EE321823BFD0A" modified="2014-03-19" version="1">MARHITASHGPDPAPGQQERTALLDASRLAESWLDRECEFAQVNVQPACWSRAEWIEHTFSSWQSVVEPVLVSLTEAMTGLMSPDGPNDPMAALTQMMGPVLRRMSAMLYGAQLAQGSQNCRPQQSPAPRLAYRCYLYLKSSSSPPISPPRGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQE0</accession>
    <name>W4TQE0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Citrate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70623">
        <property type="protein sequence ID" value="GAE70623"/>
        <property type="gene ID" value="JCM18909_3978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="346" mass="38257" checksum="0DE4F1A7C5FD5F12" modified="2014-03-19" version="1">MGSSARFVDKDTHLDFGKVVATDGQVGYDVAGLLSKTGNVMIDPGFVNTASCESQITYIDGEQGVLRYRGYPIEQLAEQSTFLETAYLVLYGELPSKAQLDGFEERIRRTTLIDERMRDLFRCFPRRSHPMPVLAAGIMALSTFSQKSSGTDPDQIEAATTRLIAKVPTLAAFGYKNSMGQPTLYPDNSLSYVQNFIRMSFGFPTEPYEFNDEITRALETLLILHVDHEQNCSTSTVRMVASSGANMYAAVAAGVNALSGPKHGGANQAVLEMLQFIRDSGMTTKEFVRKVKDKESDIKLMALATESTRTTIHAPPSSRNMPTALWNSIPVVRTFSRSPRNLKRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQR0</accession>
    <name>W4TQR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70569">
        <property type="protein sequence ID" value="GAE70569"/>
        <property type="gene ID" value="JCM18909_3916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10775" checksum="29DA47EE8117B2C2" modified="2014-03-19" version="1">MARSAFDPGDVTYHGKKAISHADHATLAAAARQAGLSYITWSPGQALTPPQVSLRRTTHMDQVSPGTDLSWILGLVAGVDVAIQLTMSARRLRRARKDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDH7</accession>
    <name>W4TDH7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_29</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67000">
        <property type="protein sequence ID" value="GAE67000"/>
        <property type="gene ID" value="JCM18909_29"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37689" checksum="7EEE76DCD376820C" modified="2014-03-19" version="1">MSWTVSDIFDHTSHGGHAVQQGHFHVTNRWFPFEVVLCYLAARTHHESGMCDDYLMTDRPVPADKSWTALTDAGRGILDAVATAPATVVLALDFDGTLAPIVDDPAASMMAQESREAMSRMDGKLAAMAIVTGREVAAVRRMTAVDQQPGLEHLVVLGQYGVERYDAASGALRDPEVPEAVRLAKGRLEELAEELGREDPRDKGCWIEDKGRAVALHTRRASDPTHALATAVPRVREIATDLDLHCEDGRNIIEVKSAVTSKAQALRELIDEVEPQILIMCGDDLGDVPALEVVAEWINTGHPGARVVSFSGEQPLMADYADVICDQTEGISAFLRDLADRVCVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE09</accession>
    <name>W4TE09_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioA</name>
        <name evidence="6" type="ORF">JCM18909_36</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67006">
        <property type="protein sequence ID" value="GAE67006"/>
        <property type="gene ID" value="JCM18909_36"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="319"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="432" mass="46916" checksum="3A44FC76891E0B37" modified="2014-03-19" version="1">MSPEQQLLEYDRRHVWHPYAPTIGVDPMLAVTAANGVRLQLHDGEHHHEVIDAMASWWCQIHGYRNPVLDEALNRQSSQFSHVMFGGLTHKAAVDAVMSLVRLARALDRIFLADSGSVGVEVSLKLARQVQIARTAARGGSLTRTRVAALRGAYHGDTLGAMSVCDPIGGMHAMFSDSIPQQIFLPRPPSFAADEAVVETWCSEADEILDAYRDDLAGIIVEPIVQGAGGMWPWSPSCLKHLRRRADELDLVLIADEVATGFGRTGKLFACEWADIVPDIMVVGKSMTGGYLTQSAVLCSDELASEVSRGPGGSLMHGPTFMGNPLASAVTAASLAIISQGQWNDDVTRIADVMSRELASLRNVPGVIDVRVFGAIAAVQVDTPIAMRRATRTVVENGVWLRPFRDLVYAMPPYICTNDDLELWPLGCVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEC2</accession>
    <name>W4TEC2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the relA/spoT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67315">
        <property type="protein sequence ID" value="GAE67315"/>
        <property type="gene ID" value="JCM18909_362"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="397"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="661"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="735" mass="81907" checksum="CAEBF3893CFADBEF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TED3</accession>
    <name>W4TED3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23S rRNA (Uracil-5-)-methyltransferase RumA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67146">
        <property type="protein sequence ID" value="GAE67146"/>
        <property type="gene ID" value="JCM18909_186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="5">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="393" mass="41857" checksum="83F4653B985C0EF9" modified="2014-03-19" version="1">MHESVGASQGDEFDLGMGNIAHGGYCVARLDGRVVFVRGALPGEEVRVRLTDISKASHWFGQAVDVISADSHRVVPPCPVAGGCGGCDFQHVDVEFQRELKRRVVAEQLSRLAGIKWAGTVEAVTGSSDGLGWRTRMQYRSLNQRPALRRHRSHDLVQVPEGGCPIAHPAGRPAAEAACNTAEHAIVMVTSCLSEDPEVSVIADGQLVAGGETMTAHVGQRRWKVGAGGFWQVHPGAAEALADAVIGGLEPQQGDEALDLYCGVGLFAGLLADRGVRVRGVEVSRQAVALARRNVPGGRFTAGRVERVLPRMAPKANIVVLDPPRKGAGKTVVQAVARTSPRAIAHVACDPAALARDLHLFDVNGYLPRSIRAFDVFPMTHHVEAVAILEPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEL4</accession>
    <name>W4TEL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67231">
        <property type="protein sequence ID" value="GAE67231"/>
        <property type="gene ID" value="JCM18909_276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malt_amylase_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8653" checksum="FB03CC0EDABB14AE" modified="2014-03-19" version="1">MAVMSFLRHNEHETVLCLANLSDTERTVALHLPQFAGVTGSSLIHGQDAQPVKADGTLSVPLWPYGYRWLQMSGEERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TER3</accession>
    <name>W4TER3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67440">
        <property type="protein sequence ID" value="GAE67440"/>
        <property type="gene ID" value="JCM18909_501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="2">
        <location>
            <begin position="142"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="461" mass="50543" checksum="DB9D7729B338A32F" modified="2014-03-19" version="1">MSIDADTWGSPSPRPADLVDEAVDQVHTWLRDANSASKRRTDRAQIAAGLLSDVLSHPAGLPFTLAFIDRVVRPEDARTAAANLAELAKADCSFLPAALQMAVRAGGRMAPIAPDVVVPAARHALRQLVGHLVVDARPAQLTRTLKALRSSGVRLNLNLLGEAVLGDREAASRLEGTMALLARDDVDYVSIKISAVVNQLDLWAHKATVDEVVEQLLPLYHMAANSPKPKFINLDMEEYHDLDLTIEVFQKLLDRPELRLVEAGIVLQAYLPDSLSALQGLVEWADRRTAAGGAGIKVRLVKGANLAMEKVDAEIHGWQQTPWPSKLATDTNYKRILDWALTPERTHSVRYGVAGHNLFDIALTKLLSEHRGVRDRVEFEMLLGMAPDQVERIGADVGGLLLYTPVVDPAHFDVAISYLVRRLEENAASENFMSAVFQLGHDSQLFAREEARFRTAVAGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TET8</accession>
    <name>W4TET8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_76</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67042">
        <property type="protein sequence ID" value="GAE67042"/>
        <property type="gene ID" value="JCM18909_76"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021412">
        <property type="entry name" value="DUF3052"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11253">
        <property type="entry name" value="DUF3052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14608" checksum="312CCEEEA1FFA988" modified="2014-03-19" version="1">MGSGSDLDKLGFEAGQVVQELGWDDDVDEDLRQEVMDIIDGDMIEDSIDAVDIVWLWLRADDGDVADGLVDAMRDLSDDGFIVLVTPKVGRPGTIDPADLSDGTDTAGMVLTTSYDVSKDWQAHKIVRPRGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEV7</accession>
    <name>W4TEV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_97</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67062">
        <property type="protein sequence ID" value="GAE67062"/>
        <property type="gene ID" value="JCM18909_97"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5513" checksum="4D91E47431D902AD" modified="2014-03-19" version="1">MERGQKEASSELISAICTALDLPQSDLMRIVSDKMLKNEDAPEHRITVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEW8</accession>
    <name>W4TEW8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67072">
        <property type="protein sequence ID" value="GAE67072"/>
        <property type="gene ID" value="JCM18909_107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7227" checksum="78FDE4608ECF5853" modified="2014-03-19" version="1">MVTGTIEAVDIIVFILVLGGLIGVVKASGAFEAGLGRLTARSKGKEFFACLLRISLHDRRWHDLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF03</accession>
    <name>W4TF03_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_27</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66998">
        <property type="protein sequence ID" value="GAE66998"/>
        <property type="gene ID" value="JCM18909_27"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE66998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9414" checksum="BA4806841044167E" modified="2014-03-19" version="1">MKLSALEQIPLFVGHDVTQTLDETVTLAQKLEEIGFHRFWLAEHHNTDHFLSSAPDLLIARIATATQSIRLGSGGVMAMHYGPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF55</accession>
    <name>W4TF55_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoglucosamine mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67595">
        <property type="protein sequence ID" value="GAE67595"/>
        <property type="gene ID" value="JCM18909_667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_III" evidence="2">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="1">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="14962" checksum="87059EC1FEB77331" modified="2014-03-19" version="1">MGDRYVLESMNANGFSLGGEQSGHVIMSEFATTGDGVLTGLHLAARVARTGKTLKELASVMTRLPQALINVRGVDKLRAGIDPDVNKAVADANQKLGDAGRVVLRPSGTEPVVRVMVEAGTQEEADQICSELAETVKMSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF85</accession>
    <name>W4TF85_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67192">
        <property type="protein sequence ID" value="GAE67192"/>
        <property type="gene ID" value="JCM18909_235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="200" mass="21793" checksum="F1624B5E552E33BE" modified="2014-03-19" version="1">MKGDDMATTGEQPSVEIPLDGHARRGQDALFEGDFAPLPEDIGFRGPVASGAAGISYRQLDYWARTGLVRPEIRAARGSGSQRLYSFRDILMLKVVKRLLDAGVSLQQIRVAIDHLRSNGAEDLSRVTLMSDGVSVYECTNDNEVIDLLHGGQGMFAIALGGVWRDVQGSLAELPSERLNPVVDTELDEFTARRIAKHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFA6</accession>
    <name>W4TFA6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67212">
        <property type="protein sequence ID" value="GAE67212"/>
        <property type="gene ID" value="JCM18909_256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6140" checksum="B9551FF148649E6F" modified="2014-03-19" version="1">MSTKDVSDGQFDEETGLNLFDDTASAAGSFTHSMWGYDRTSVDNYVREIEQQVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFE4</accession>
    <name>W4TFE4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartyl-tRNA(Asn) amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67247">
        <property type="protein sequence ID" value="GAE67247"/>
        <property type="gene ID" value="JCM18909_292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="330" mass="35557" checksum="6DFB36CEE5AB98D1" modified="2014-03-19" version="1">MTGTVGIKPTYGSTSRYGVIAMASSLDTPGPCARTVLDAALLHQAIAGHDAMDQTTINQPTPAVVEAARQTDVSGVRIGVVTELSGQGYDSQVEARFHEAVKMLIEAGAEVVEVSCPNFDLALPAYYLIQPAEVSSNLARYDAMRYGLRVNDDGEHSAEQVMRATRGAGLGAEAKRRIILGTYALSAGYYDAYYGSAQKVRTLIQRDFEKAWQMCDVLVSPATPTTAFRLGERTADPMAMYRSDLCTVPANMAGSPAGSFPIGLSETDGMPVGMQVMAPIMADDRIYRVGAALERLLHEKWGAQLLAKAPEMRESDDRRAVALRRSDGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFH4</accession>
    <name>W4TFH4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialic acid utilization regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67277">
        <property type="protein sequence ID" value="GAE67277"/>
        <property type="gene ID" value="JCM18909_323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10773" checksum="08210C8C6CD85E14" modified="2014-03-19" version="1">MDDSLLPRIDMARTTMRPAEAQVAAVILAKPDWTLAASTSQLAELPAYPPRLSCAFAEPLMSGYRELRTELARDLSRRTLELERSSVLRALLLSTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFK8</accession>
    <name>W4TFK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67223">
        <property type="protein sequence ID" value="GAE67223"/>
        <property type="gene ID" value="JCM18909_268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5849" checksum="B42991D2AB85CEAA" modified="2014-03-19" version="1">MLASPWSFFDPTVIDEAGYSKITPVLVTNGFDYSNVTGIPADDVTTGTPVITVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG52</accession>
    <name>W4TG52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67771">
        <property type="protein sequence ID" value="GAE67771"/>
        <property type="gene ID" value="JCM18909_854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="14835" checksum="6B8CCAB5B73E4E94" modified="2014-03-19" version="1">MKNYCMPDPGEGLTEGEVVSWQVSPGDTVKINGVLCEVETAKSIVELPSPFAGTVAKLCAEPGETVAVGAPLVTIDDGSEDEPEFLVGHVTAEPGRRRRRRRGAAVSTERAREEGVDTHPEQSVSEPQHDARRNRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK7</accession>
    <name>W4TGK7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_1209</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68095">
        <property type="protein sequence ID" value="GAE68095"/>
        <property type="gene ID" value="JCM18909_1209"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="210"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE68095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="340" mass="36760" checksum="6F629C498506C394" modified="2014-03-19" version="1">MRQPVADHGIRLLAVATLYGLGEGSTLGRIRVQPDSHHRLPNVSVPEESSTVVIGNFDGVHRGHQALVQEAKRLDPDGYVVVVTFWPHPLTVVAPDQAPALLCSLERRIEWLKNAGASEVRVVNFTTEIASWAPAAFVERVLGPLQPRHVLVGQNFRFGRHAVGTPDALAEHGCFQVHAMDLVAISGVTVSSTRVREVVAAGKITEAAELLGRPFEVGGVVVMGDQRGRELGFPTANLVVPQDRAVPADGVYAGWLEPSSGPDAGRRLPSAISVGTNPTFDGVERRVETYVIDRDDLELYGVDITVTFAERLRGQIKFDGIEPLISQMADDVEVAKRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS7</accession>
    <name>W4TGS7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron(III) dicitrate transport system permease protein FecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67628">
        <property type="protein sequence ID" value="GAE67628"/>
        <property type="gene ID" value="JCM18909_701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="18772" checksum="A3E3F3F7C317C45E" modified="2014-03-19" version="1">MSNTDVSLAREDPATGMVAVVRGYYRRARWKRWAIVLLSVIAVAAFLVTIVVGPVDITLPQLLRALVNPSTVDAQTRMVLWQLRIPSSVMAVLIGVCLSLAGAHMQTILDNPLAEPFTLGISAAAAFGAAALSSWGGRSFPIPNSTWRSAQQWHPLLRLPSLPLSHAAVKRAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU2</accession>
    <name>W4TGU2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68185">
        <property type="protein sequence ID" value="GAE68185"/>
        <property type="gene ID" value="JCM18909_1306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="18352" checksum="4B4DA5EAE71C3675" modified="2014-03-19" version="1">MYVASLKAARTELMAYLTRRCEADGHGDTVQACIGNVGANDKDGYYNTFTDSVSTTPVVDRASALKAYRARMTYGFDKASAYGGPAPATTAPVVPAGAENLLSTAFPTLSDAQRRQVLAATEIDAGYALDSSSGGWQRINLAAAMSAKVTVDKAGHVVKVETGNLKPEVVSAPQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGV7</accession>
    <name>W4TGV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric-oxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68200">
        <property type="protein sequence ID" value="GAE68200"/>
        <property type="gene ID" value="JCM18909_1322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="24423" checksum="403375536A179750" modified="2014-03-19" version="1">MLILSRQQTAAYHHLVSYYTTYFGRNSHNLGLLAHDVKDPAQARHLTDFFAWTAWGAAADRPGHSYSYTNNWPADPTVANRPTADMVVWSVLSLIVLIGGTGVMFAIYGRWSKNIGWHESETPSLSFIPPSQVGLTKSQRATSWFFSSSLLFCSSSRPLLVRRQSITGRIFRVSSGSIWRPGCLITLPEPGMFSWRCSGRRQPSLPAASSWLPSSQVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGV9</accession>
    <name>W4TGV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68001">
        <property type="protein sequence ID" value="GAE68001"/>
        <property type="gene ID" value="JCM18909_1106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5895" checksum="E5B3EEE572BE7747" modified="2014-03-19" version="1">MKFSQFGREYSVKLTELPGMGHIEPVQKRVDANSPGQMRVEFRRNLTVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE0</accession>
    <name>W4THE0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/acylhydrolase with GDSL-like motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67853">
        <property type="protein sequence ID" value="GAE67853"/>
        <property type="gene ID" value="JCM18909_943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848756" evidence="1">
        <location>
            <begin position="31"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="89"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="302" mass="31268" checksum="6F8914FA70A4FF74" modified="2014-03-19" version="1">MKRILKILSVVVAVVGVAGIAIGLRPHTHAFGSVFQIRYRSSAASAPGPATSAFSAVSSTVTPLQAPTPATYAAGPVTGHGGTLATLGLGDSVPQGGTCTGCTTFIERVGTDMARKAGVKAAVHNESVSGYKTADLLTQLESNNAKALLATSDLAIVTIGANDFDLDTMVGQCAHSDASCIAGDVDGVTDRVRTILERVKAAMKTPRATVVVTGYWDVGLDGKAGRDNGPDYVKVTDMITEAFNANVKKIAHEVRAVYVDFRTPFRGADGTRDDTALLTDDGDHPSEEGHKVLAEAVEAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF5</accession>
    <name>W4THF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Two component sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67868">
        <property type="protein sequence ID" value="GAE67868"/>
        <property type="gene ID" value="JCM18909_959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849089" evidence="4">
        <location>
            <begin position="18"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="6">
        <location>
            <begin position="185"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="5">
        <location>
            <begin position="305"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="433" mass="47140" checksum="5DE1A14FF21D9200" modified="2014-03-19" version="1">MILDSVMAFLVLVAAFASWGHDTNHNTAYRTWMALWVLTVCASWVWARTKPEVTASVLVASHILQLAVYPFPSPQNTLVPLILYQVSLKTDPPRRRFWLAMCVVGPVSAGVSWGFAPTISEPFSYKAHLIRFCVIIIACMASCLAAWFAGSAARDRRQTMEALRQRAIDLERERDQSIRLATQEERAKIARDMHDIVAHSLSVIVVQADGGAYLAHHEEAGDIETRLSASGQALDTIATTARHALDETRRLVGVLRDNDAGPQLAPTQGLDDIPNLIKEMKGALAITLTIKSSPECHEPLSQGAELACYRVVQEALTNVLKHGGPTATAHVTISHHPDDVTLDILDDGRGTSVTGIERADGAGHGLVGMRERMSAWGGTLEVGSRPDHGSESMPSSLPIDRHLSPEGPRHDRPDPTPPGRRPADGARRVPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ4</accession>
    <name>W4THQ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67709">
        <property type="protein sequence ID" value="GAE67709"/>
        <property type="gene ID" value="JCM18909_788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14709" checksum="C2BDDBB8B0596DE5" modified="2014-03-19" version="1">MAQIITTGLSDVPAGNEPTHGDFHEGQIHVWNGHVCGILDVDTIGPGCRADDLACLVAHLSTVQRMNVPQADRMRQILTAWVPVFDSRVDPIELRLRSAAVAISLATGPYRSQEDNWQAETLSIVDAAEALVNQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS8</accession>
    <name>W4THS8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68072">
        <property type="protein sequence ID" value="GAE68072"/>
        <property type="gene ID" value="JCM18909_1184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004699">
        <property type="entry name" value="PTS_IID_sorb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40399">
        <property type="entry name" value="PTHR40399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03608">
        <property type="entry name" value="EII-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038321">
        <property type="entry name" value="PTS_glc_srb_IIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00821">
        <property type="entry name" value="EII-GUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51107">
        <property type="entry name" value="PTS_EIIC_TYPE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="21351" checksum="E97CBFD6B4AA785F" modified="2014-03-19" version="1">MRYLVEAAEWFVGLFQEGAKTFVGWMGSIVPLVLMLLIAMNSLIRLIGEDRINRLAQKAGNNPVSRYLLLPFIGSFMLCNPMVHSLGRFLPERYKPSYFASAAQFCHTSNGIFPHINPAELFIWLGIAQGITKAGLPTGPLAIRYLLVGLVLNFVGGWVTDLTTRYVSRQQKVVLPDTMDGKIVHVDTLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV2</accession>
    <name>W4THV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polyribonucleotide nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68097">
        <property type="protein sequence ID" value="GAE68097"/>
        <property type="gene ID" value="JCM18909_1211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9439" checksum="673C90141E326D9E" modified="2014-03-19" version="1">MEGPGLEFTEAIIDNGKFGKHVVRFEAGLLAQQADGSAAVYLDGDTMLLSATTAAKTPRDSIDFFPLTVDVEERMYAAGRIPGSFFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI06</accession>
    <name>W4TI06_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase-binding protein RbpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbpA</name>
        <name evidence="4" type="ORF">JCM18909_1727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Bind 1 Zn(2+) per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with the RNAP catalytic core and with free principal sigma factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase-binding protein RbpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68580">
        <property type="protein sequence ID" value="GAE68580"/>
        <property type="gene ID" value="JCM18909_1727"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001000">
        <property type="term" value="F:bacterial-type RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01483">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038638">
        <property type="entry name" value="RbpA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025182">
        <property type="entry name" value="RNApol-bd_RbpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13397">
        <property type="entry name" value="RbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13224" checksum="9FAF95BCD8FAFF34" modified="2014-03-19" version="1">MSGGSAIRGSRVGAGPMGEAERGEAAPREYVSYFCANHHVIRPAFAAEAEIPDTWECPRCGLPANRDQANPPAPPKIVPYKTHLAYVKERRSEAEAAAILAEALENLRQRRVMVRSSIEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI44</accession>
    <name>W4TI44_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68103">
        <property type="protein sequence ID" value="GAE68103"/>
        <property type="gene ID" value="JCM18909_1217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="182" mass="19741" checksum="B2BEF08FE013DFB8" modified="2014-03-19" version="1">MNERPTFSMTPSEPTQVLPSRPRTGSDTVVTVDRDRRHHRFIKWLIAMVVVALLAVAAMIVDQTFRARAEKDIATTIATSVGADASTVGVTIHNRPFLKALVTDELQGLDATIPKATVARDDTTVTFHDVDVHANGIRHVREKSQTVAETMSASGRVDWSELSRLAGAKKSPITTTLGKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI57</accession>
    <name>W4TI57_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68217">
        <property type="protein sequence ID" value="GAE68217"/>
        <property type="gene ID" value="JCM18909_1339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9476" checksum="7923F68360C6A09A" modified="2014-03-19" version="1">MILGGNAAIDEARGSTHMGRGRAKAKQTKVARDLKYRSVNMDLESLERELRGENHQQEDPHDEDGLSDEYADLAEKYAHYGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE5</accession>
    <name>W4TIE5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Single-stranded DNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68735">
        <property type="protein sequence ID" value="GAE68735"/>
        <property type="gene ID" value="JCM18909_1889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14168" checksum="6BCB5857B465E2B4" modified="2014-03-19" version="1">MDANVSFTGNLGTDVEMKIGEGWRGARFRVAHTPRVMRQGEWVDGTTTWMSVHVYGRLADNCHVSLRKGDPVMVTGRLRTRSWIDDEAPTSNSLSLHIMLDRTYPGCLPCVVDPRNAPKLPWAMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG7</accession>
    <name>W4TIG7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transport ATP-binding protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68332">
        <property type="protein sequence ID" value="GAE68332"/>
        <property type="gene ID" value="JCM18909_1461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="262" mass="27390" checksum="5ACAC905E2C8FF11" modified="2014-03-19" version="1">MDMVVRVIVPACASSLVIIGTTVLLARFSLTSAAVLLLSALLAAVVMPAITQRLSRAADSSLVPLRGQLADRTRELAHCAPDLVAYGAQDAILADVLEVDSRLRTAEKRAAWGRGLGTAGQILAAGLAVVSALWIGGNAVANGRIGGRILAVLVLTPLALHEVFGAFTGAAQTHTRAMAALQRVAEVLDAPQVGVGDSPTAAASEEKPSLVIEGLTVGWPGDQPCSRTSTCRWRLGNRWPSSAGQELERQPSRRPSWGSSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH1</accession>
    <name>W4TIH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67914">
        <property type="protein sequence ID" value="GAE67914"/>
        <property type="gene ID" value="JCM18909_1011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="320" mass="34786" checksum="709BF1D2AFD237D9" modified="2014-03-19" version="1">MSNLLRVIGKRLIALPIMVLGVVLLVFIVMSFSPRDPAILALGESATPEALAQYRAANGLNSPLLVRYGRFLAGMIHATWGPRLVAPRLRGGEPGVSHHFAADRLGSSHRCRRLIGPRRHRSLYRDRWPDQVIRVLSIASLATPSFWLAILLVQWLGDIPGGTGSFPAVVSTWIPLSENPAAYFNSLALPVIALAIPVCGSLTRVVRTSVVEELDKDYVRTAIGAGTPYHTVVARNVLRNALINPLTVVGLKFGYLMGGAVIIEIIFNIKAMGQLILDGVSRNDVFLVQGVTLTVAIAFIVINILVDVLYVLVNPRIRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL2</accession>
    <name>W4TIL2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68621">
        <property type="protein sequence ID" value="GAE68621"/>
        <property type="gene ID" value="JCM18909_1768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="9381" checksum="DBA126FCE48FEF0E" modified="2014-03-19" version="1">MGADDVASDKGIKTLVPANAESLVSINGCDLRHEDGLASTGGMKGLLARAGVANTTAGRKQRVISIPDGISLSFGPQTGEVLTAVAKALYGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIP6</accession>
    <name>W4TIP6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68835">
        <property type="protein sequence ID" value="GAE68835"/>
        <property type="gene ID" value="JCM18909_2000"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="368" mass="39401" checksum="881BA3BE712F0CB5" modified="2014-03-19" version="1">MSTALFTDHYELTMVEAAMASGTANRRCVFELFPRRLPEGRRYGVVAGTGRVLDAVENFRFTDEDVSFLERTGVVGPHMAEWLSHYRFTGSIHGYAEGDLYFPGSPLLTVEGTFAEACVLETVLLSIYNHDSAIASAASRMVMMAEGRSIIEMGSRRTHEESAVAAARAAWIAGFGPTSNLAAGIRYGVPTSGTAAHAFTLLHDTEEEAFRAQLAAYGEKTTLLVDTYDIDNAVRTAIRLTEGRLGAVRIDSGDLSIVARQVRDLLDDLGAPNTRVIVTSDLDEWQIAALRGAPVDGFGVGTSLVTGSGAPTCSFVYKLVARATSDSPDAELLPVAKKSSHKKTLWAGASMRCAASAQVESPPQRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR0</accession>
    <name>W4TIR0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68676">
        <property type="protein sequence ID" value="GAE68676"/>
        <property type="gene ID" value="JCM18909_1827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="64"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="29890" checksum="D09E10D7C4C158C6" modified="2014-03-19" version="1">MIGPVMMRTVDPFGMARHHTDLGQVAEVIVTPRIVDLGASGELGGQGFDTRSSAIHAGRRGPDDAMVRDWHTGDSVRRIHWRSTAHRGDLMVRREEQAWNPSVAIVLDSRARRHAGTGPDASFEWAVNAVASISTRLASDGYVTHVCDSSGTLKGDILDTLVDEPLRPDTTLTKAIESCQGIDGPAIAILGRLETADIDPLVDLRRDRVAGLALVLDSDTFTARRFRSSLEQAEEHERAVAELDDAGWAVVPVDSRTSIDSAWQNLLQTTRTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS5</accession>
    <name>W4TIS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68691">
        <property type="protein sequence ID" value="GAE68691"/>
        <property type="gene ID" value="JCM18909_1842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="12808" checksum="0C4DDFDD74C0E1C2" modified="2014-03-19" version="1">MAASLTAMGHVLATRRARDPQTRGVAVLGDMLELGQDSARLNAESGRRAAHAGFDVIIAVGDEAENIAEGARAEGARVIVSTVEDASGSLGWTSHDVVLLKASRGLALERVGRDVFEEGEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ45</accession>
    <name>W4TJ45_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68184">
        <property type="protein sequence ID" value="GAE68184"/>
        <property type="gene ID" value="JCM18909_1305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="acidPPc" evidence="1">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19474" checksum="B9CB39F484AF9155" modified="2014-03-19" version="1">MAEGLAQCTPANVHSCSLTHVARFLWSTGFQEVTKKSTGPAKKYFNYPRPYLADRSFADSGNPNNLRGLKKNLAIARVPSRIDVNHKRGGRALLTAGYDLMDGASGTDLTVSQAFPSGHTTAAYAYGLAMAEILPELGPEILTRASEAGNNRAVLGVHYPMDIMVGASRSQQRVRRADHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE5</accession>
    <name>W4TJE5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68538">
        <property type="protein sequence ID" value="GAE68538"/>
        <property type="gene ID" value="JCM18909_1683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="78"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="270" mass="29119" checksum="C49BCF2EEC48914A" modified="2014-03-19" version="1">MKLDPRLAEILDRQPKEEQTLAEKRARDNDAAARLRGKITPAVPDSVILEDRTVPGRTHPIPVLIQRPKGLPNPAPVLVWAHGGAFVHGSPRTVLSRTASIAQRAGVCVVSVDYRLLPEHNYPENLHDVVDVVRRVAETGPDKGFDTSRILVGGDSAGGNLAAATGIMCRDEGNPAILGHILEPVLDLSDTSEAMAEARRDAPDLAAALHHSHVRYLSYGASLDNPLTNPACLENAHGLPPTFFCSTVRWIRCVTTRSHGSTSSRTPGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG3</accession>
    <name>W4TJG3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmH</name>
        <name evidence="7" type="ORF">JCM18909_1833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68682">
        <property type="protein sequence ID" value="GAE68682"/>
        <property type="gene ID" value="JCM18909_1833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="346" mass="38110" checksum="200B91AF665F0643" modified="2014-03-19" version="1">MLADHAGEGMLMATDAIGSDAVHIPVMRARVLDLLAVVLKSGRRVHVDGTLGMGGHAEAVLRRFPDVELVGIDRDQQALTMAEARLEPFADRVHLVHAVHDELPEVLDDLGLDYVDSVLLDLGLSSFQIDEVERGFSYSVDSPLDMRMDQSSGRTAAQILNESGPGALVRMLREYGEEKFADRIVRAIVTERDRQPIETSGRLVEIITEAIPATVRRKRHSHPAKRTFQALRIAVNREMETLPAVLPRALDRLDVGGRIAVLSYHSLEDRPVKEAFRDACADTAPAGLPMVPESMAAKFNPVTRGAERPDADEVATNPRSASARLRVIERVRPGPVNRQHATKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ8</accession>
    <name>W4TJJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-N-acetylhexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68717">
        <property type="protein sequence ID" value="GAE68717"/>
        <property type="gene ID" value="JCM18909_1870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850775" evidence="3">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3" evidence="4">
        <location>
            <begin position="84"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="298" mass="31234" checksum="39CACCC339277744" modified="2014-03-19" version="1">MRRRTIIAAGLSMPLTGCVSQDSQPKGPPSTTVTASPTPAGTSTSSSASPTSAPSHASTATSRPTPIRMNPRAVEIAKKLSPEQRAGQCILVGVVPSDSPEYITNLIDTQCLAGIFLLGHWTSRSKLEAMLSAVNHVSPQGIKPIVATDHEGGEIQNIRVPGVDHLPSQEALARMSPAKVQAVVTTGARQLAKLGVHMVFSPVAGVIDPRLGYAISQLPSIIVVSEPIRTSAGNTRQPSLRDTAKPGSFRPLSIFLASDGSRRILTSNPPGLLTTRPPATTDISSLSGWPLMLDLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK7</accession>
    <name>W4TJK7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68951">
        <property type="protein sequence ID" value="GAE68951"/>
        <property type="gene ID" value="JCM18909_2128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12711" checksum="A9643E1B624C5D82" modified="2014-03-19" version="1">MSELKNDVVSGTLLTGEHVIDDLAGIIVTTVRNTPGVTRVVKPWWRRVGDDDRSAIRISEENGLSDVEVEVTVDLTVPIVQLTQDLRHRVSTAITQSGRTPGKVDIVVSKVEPNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS1</accession>
    <name>W4TJS1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR-like ATPases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68678">
        <property type="protein sequence ID" value="GAE68678"/>
        <property type="gene ID" value="JCM18909_1829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_lid_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6762" checksum="063F8AC0467C623C" modified="2014-03-19" version="1">MSGRDYVIPDDVQALAAPILAHRLVFSGRSGIASHESARAAESVIESILRQVPLPERAHQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT3</accession>
    <name>W4TJT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">D-alanine-D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68394">
        <property type="protein sequence ID" value="GAE68394"/>
        <property type="gene ID" value="JCM18909_1529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="144"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="302" mass="32468" checksum="347367F5DCDC2CEE" modified="2014-03-19" version="1">MNRIHVAVIFGGMSSEHSISCLSAANVVAAIDAERFDVSGVGISPEGIWVRYGADEVLALPGTGQLPTVEVGDRPLVSVKQMPEGTCIVDTEGNVDAVQVVFPVLHGPFGEDGTIQGLLEMAGVRYVGCGVAASANCMDKHLTKMILSEAGVLVGPYVVVRDHEWREDRNAVLKAASRLEYPLFVKPARGGSSIGISRVTNPEHLEAAIEMAREHDRKVLIEQGIRGREIECSVIDGRHGAAPRASVPGEIVVHDPDGFYDFEAKYLSGEQKASVQAHANLDDATRRRVQKSRDQSVPGAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK93</accession>
    <name>W4TK93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permeases of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68564">
        <property type="protein sequence ID" value="GAE68564"/>
        <property type="gene ID" value="JCM18909_1711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9428" checksum="6755EA8F0DB4A02A" modified="2014-03-19" version="1">MVAAAGLLAFLLKDVPLSHHTGLQMRAASEAEMEGAQEVPAVEGQENLLESGHGDLSDGLAESSACRATDVMKVEAAPPRRSVGSDQSVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKB6</accession>
    <name>W4TKB6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA topoisomerase 1</fullName>
            <ecNumber evidence="8">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">topA</name>
        <name evidence="11" type="ORF">JCM18909_2043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="8"/>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68873">
        <property type="protein sequence ID" value="GAE68873"/>
        <property type="gene ID" value="JCM18909_2043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025589">
        <property type="entry name" value="Toprim_C_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13368">
        <property type="entry name" value="Toprim_C_rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="8">
        <location>
            <begin position="161"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="845"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="885"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="8">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="914" mass="101083" checksum="214807816BD74D60" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC8</accession>
    <name>W4TKC8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxygluconate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68967">
        <property type="protein sequence ID" value="GAE68967"/>
        <property type="gene ID" value="JCM18909_2145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="330" mass="35345" checksum="3DD34CD328587A28" modified="2014-03-19" version="1">MSRVFGKHAAVITSLVDDPVGRLVGDLITAGGVDDQFITWVPSDGVGRTVRTGLNFTERGFGVRGAVGVSDRGHTAASQLRAEDIDVDRLFGQLGVRWLHTGGIYAALSQTSAQTAKAVMAAAHANGTVISYDLNYRPSLWKSVGGQEEARRVNRELARLVDVMIGNEEDFTACLGFEVEGNDENLSHLDVNSYATMIDKVVEKFPNISVVATTLRQVRTASRNDWSAIAWSKDTGLVRSVERPNLEILDRVGGGDSFAAGLVAGLMETGDLQKAVELGAAHGALAMTTPGDTSGHPLRSGIVGSRRICTSETLIRSVAGRRATRRPFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD2</accession>
    <name>W4TKD2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flp pilus assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68888">
        <property type="protein sequence ID" value="GAE68888"/>
        <property type="gene ID" value="JCM18909_2059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="69"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="286" mass="31302" checksum="774A637A0C290A63" modified="2014-03-19" version="1">MSREEPDLKLVEQVRRRLAGLARDWTPMDVAHAILDCGRVASDKTVLAVVEELRRTSTGAGRLDPLLVMDGVTDVLVNGLNQVFIDRGQGLELTDVTFSGPEEVRALAVRLAAAVGRRLDDGNPWVDAMLPDGTRVHAVLDVLARPGTCLSLRVPSRRCLSLDDWVTGGSMAPGCRRMIDTILSRKLAFLVTGGTGTGKTTLLSAMLTSLPSDQRLVIVEDSREIWIDHPHWVSMEARAANSEGKGSVTLTDLVRQCLRMRPDRNRPWRGARGGTARSPHGPQYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD3</accession>
    <name>W4TKD3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MerR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69256">
        <property type="protein sequence ID" value="GAE69256"/>
        <property type="gene ID" value="JCM18909_2452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14195" checksum="57F502A4342FE37E" modified="2014-03-19" version="1">MDRPVNIREVEATRVISMTRVVSIDKLGPFMDEAFGILERLAPGDPTLGKASPFVIYHDGLTAEHDGTVEVCQPIRGTIDDAVLPLDVAVRTVEAHREAWVTVTKAELEYPDIDEIYDAFDAWSKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF4</accession>
    <name>W4TKF4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-sulfur cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69415">
        <property type="protein sequence ID" value="GAE69415"/>
        <property type="gene ID" value="JCM18909_2625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="305" mass="32991" checksum="886CF33FC5C73755" modified="2014-03-19" version="1">MAETPQDRLSALAAADPHAVNRRVVIPAETSLKAPVEVTVVGHNDDIACHHNVVVEIGNHADVTVIVRHRGVAHLGENWTFRIGDGAQATVLFVQEWDDTAIHGAQVSFEIGRDATVRTAQASFGGKAVRICQTASYNGPGGNLTQLGAYFADAGQHIEHRLFVDHNAPSTESHVDFRGCLQGKDAHSVWIGDVLIRPVAEDIDTYESNKNLVLTEGCRADAVPNLEIQTGNIRGAGHSASTGRFDAEQLFYLQSRGVEEAEARRLVVHGFFTDIVRKIGVPEISEELVARIEAELVESLGSSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH1</accession>
    <name>W4TKH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carotenoid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68659">
        <property type="protein sequence ID" value="GAE68659"/>
        <property type="gene ID" value="JCM18909_1810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19817" checksum="F6435B04E454FEEA" modified="2014-03-19" version="1">MILHRMTPQTRSSTRRHQLPDAPGGIARLVHGVLPPPLSAPQARCPRIMAWPTGWTGRPKARRNVVLVGWRTSHRICHDYTRPIPNPELGTAWSAWQDRPPMVWRQEGSIPVLAASPASHGGPEPWARLLTGALAAYLTHERLTGEDIRPSNKAIGAAGRPRRSHSSTDRVSTRRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI2</accession>
    <name>W4TKI2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69450">
        <property type="protein sequence ID" value="GAE69450"/>
        <property type="gene ID" value="JCM18909_2666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5160" checksum="50A81C5726DD9279" modified="2014-03-19" version="1">MGPTKVTMGIDGGTATTRRAAPSLPVSVLWMCKVVVRVLSGVTGMCTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI3</accession>
    <name>W4TKI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68918">
        <property type="protein sequence ID" value="GAE68918"/>
        <property type="gene ID" value="JCM18909_2091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="6">
        <location>
            <begin position="31"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="25455" checksum="3609D20E922401C9" modified="2014-03-19" version="1">MTDVNPVRSDNCRQYNNVPPQIDLPAMDHEIIDLWARQHTFDKSLVASKDGQPWTFFEGPPTANGQPGTHHVEARVFKDIFPRFKTMQGFRVDRKAGWDCHGLPVELAVEKELGFSGKPDIEKYGVEPFNAKCRESVTRHVDAFSELTERMGYWVNMDEAYWTMSRPTSSRCGGVLSESGIRVCSVRTTAWPRTARAAVPLCPTMSWLRVTRMTAIRRSMCGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK0</accession>
    <name>W4TKK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69470">
        <property type="protein sequence ID" value="GAE69470"/>
        <property type="gene ID" value="JCM18909_2689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21390" checksum="E713437A2C636D61" modified="2014-03-19" version="1">MPPSADDVFILRGPLARKSLRLGVLNLPNPSERLGWLVQHLSELPKSGIIYCLTVSTAEDTARALTTAGHNVRAYTGRTDAEARTELEEALRNNQVKALVATSALGMGFDKPDLGFVVHLGAPSSPIAYYQQVGRAGRATDNADILLLPGPEDPDIWTYFATSSMPTQERANAVLRALAGGQALSIPALETRVDIRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK1</accession>
    <name>W4TKK1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68689">
        <property type="protein sequence ID" value="GAE68689"/>
        <property type="gene ID" value="JCM18909_1840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="1">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="21522" checksum="13D90CFCE39FCA31" modified="2014-03-19" version="1">MPHLVVDDGQAGLSRLARHVVATERERGMRTIALTGSSGKTSTKDMLAQILETFGPTVAPVGSFNNEIGVPLTACRSNENTSFLVSEMGTRGLGHISWLTSIVTPDVAMVLNVGSAHLGEFGSREVIAQAKGEIVEALSVDGWAVLNAADTLVAGMAPRTRGHIAWFSLMLTIVARMPTLRCGPNQPCRRPGSSLLYPCRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM4</accession>
    <name>W4TKM4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69495">
        <property type="protein sequence ID" value="GAE69495"/>
        <property type="gene ID" value="JCM18909_2716"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="23143" checksum="B55C4828527F9D27" modified="2014-03-19" version="1">MASAGRTHLGSRAGDNALTDYQTVLRSELVDDVEAVLVLGHPTLSRPVSRLLARPDVTVVTDHSRWTDVAGVARVVTGPVELAEIDTDPAWLGRWKDADRPVVPTAKQRLCRDIWWACMTPNAPVLVIGASEVIRCFDRFAVPGDIAPTALANRGLAGIDGTIATAIGVGLGTRRPVRVVVGDLTFAHDAMSLLLGETEPEPDVQVVVLDDRGGAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP5</accession>
    <name>W4TKP5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69102">
        <property type="protein sequence ID" value="GAE69102"/>
        <property type="gene ID" value="JCM18909_2289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18960" checksum="33AE43CD082304DB" modified="2014-03-19" version="1">MWRVTSSIDNGADRVTHGFLGWFGMDDPSQTYNVTGFDFSSWLKAFFTMFLAVAVVFAVRPLFIKMVYAWRQSRQTWEVAYTVNSVATLSSTFVVAVVSLLWFVPSGALVPVGLVMLWALGAMCQFLGELLLYTGVNKTGEFPPYSRSPLVPHVIGTGFYVVVVAYSGCSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU2</accession>
    <name>W4TKU2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69396">
        <property type="protein sequence ID" value="GAE69396"/>
        <property type="gene ID" value="JCM18909_2605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6415" checksum="7CCCCF81BE0396F5" modified="2014-03-19" version="1">MLPGASRPATSPVLPGDVVRNRYSTCSTVAGRTTGDCVQRRADTDNPIRKVGDEDIGGQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW0</accession>
    <name>W4TKW0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69068">
        <property type="protein sequence ID" value="GAE69068"/>
        <property type="gene ID" value="JCM18909_2251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20696" checksum="3E09620A65067867" modified="2014-03-19" version="1">MIRSLVATLATGAIVTAGARCPLRPCRYSTKTPRTQPPSALPARIRVTPGRPFMWCAATSMALLGRGRSPTTTTLRCRSRDPSQKLRRKNWSVSAGIDFPLLDVIHISISSSYSTSSTYEVGETVGPYDVAPGKTAVLQAGWIVSDFEGQHTVCGPDKKWQGRGDHFTATLPREHHVRISTRDNVQYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL36</accession>
    <name>W4TL36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replicative DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69247">
        <property type="protein sequence ID" value="GAE69247"/>
        <property type="gene ID" value="JCM18909_2443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7770" checksum="894A56EDEB0F8D51" modified="2014-03-19" version="1">MMSDLRESGSLEQDADVVILLHREDVYDKESPRAGEADIIVAKHRNGPTRTVPVVFQGHYSRFVDMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL95</accession>
    <name>W4TL95_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein-L-isoaspartate methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69213">
        <property type="protein sequence ID" value="GAE69213"/>
        <property type="gene ID" value="JCM18909_2407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="26254" checksum="E3C57DAB2C3616DC" modified="2014-03-19" version="1">MRPILSEFTVSMPREAAIIYPKEAAQITMWADIFPGARVLEAGVGSGGLSIPLLRAIGAKGRLHSYERRQEFADVARKNVESFYGEIPSTWDLKVSDLVSGISSELIDRAILDMLAPWECVETVGKVLVPGGVLCCYVATTTQMGRVMDTLRAHGGWTEPSATETTTRDWHAEGLAIRPAHGTTGHTGFLVISRRLAPGVAAPMRKRRPAPGAYGPDYHGPRPRNITEHDQWRLPKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL96</accession>
    <name>W4TL96_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">B3_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69302">
        <property type="protein sequence ID" value="GAE69302"/>
        <property type="gene ID" value="JCM18909_2503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B3_4" evidence="1">
        <location>
            <begin position="76"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="246" mass="26868" checksum="E0334A3ACC14AC82" modified="2014-03-19" version="1">MPEPMTPETFLDACTVDEAVFKLRPDYRALLLVVDGLTPPASGEGNDMVDTLIAQAEAHARNLLADSPVNELAHIASWREAFRGFGAKPQRTRNCLEALTRRAEKGLPRVNALTDVYNAISVLHQIPLGGEDLHRYNGPARLIRATGEESFDTTANGEAVIEHPEIGEVIWCDDAGVTCRRWNWRQGRRTGLTDTTRTALFILDALAPVTDEELLATADALTEALANLGENVQTTTRLIGAQPSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA3</accession>
    <name>W4TLA3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69521">
        <property type="protein sequence ID" value="GAE69521"/>
        <property type="gene ID" value="JCM18909_2746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005451">
        <property type="term" value="F:monovalent cation:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030151">
        <property type="entry name" value="NhaP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32507:SF7">
        <property type="entry name" value="PTHR32507:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="13"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="286" mass="28681" checksum="3C61F5D67A14C1AF" modified="2014-03-19" version="1">MQPADLALFLGAVVVLLAAFAARIGTRLGLPALLLFLLVGMLLGPIGFGINFNDLAAAHAIGFAALVLILAEGGLSTNWKDIRPALAPAALLATVGVGVCFGVMTLLGHYVLGLHWSVAALLGAATAPTDSAAVFSVLRGVSLPNHLRSVLEAESGLNDAPTVLVVIALTGVATGDSSPGVLPLLGSIAVQLIGGILVGLLVGWVAGKVSRRITLPSGNLYAIAAMAWAVTAYGTGVWIASPGFRPSTSPLSSSATAIFPTNTPPGPSQKASPGSARSAYSSCSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG1</accession>
    <name>W4TLG1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69820">
        <property type="protein sequence ID" value="GAE69820"/>
        <property type="gene ID" value="JCM18909_3075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="12419" checksum="1327A2C162C30E9F" modified="2014-03-19" version="1">MPALLMIAAVATGSWRISEVKADAQSAAQVAARAGSVASSVGEGIAVGQRVGLAELAGTRCSKPAIAVDSSDLTLPVGSAGTTSARVSCTIKLSDLLVPGMPGSFHIESVAHSTLDSHRERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH9</accession>
    <name>W4TLH9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69601">
        <property type="protein sequence ID" value="GAE69601"/>
        <property type="gene ID" value="JCM18909_2838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="11180" checksum="3EA1165FB487DB24" modified="2014-03-19" version="1">MIDLTDLLPPAAIRLDAHVKDWREALQAVGHLLVATDTATPRYTQAMIDNLEKKMVLTSSSPLDLHWPMPDRTPQCCGQACRGYVLTNRWHSATRRTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN6</accession>
    <name>W4TLN6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphohydrolase MazG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69084">
        <property type="protein sequence ID" value="GAE69084"/>
        <property type="gene ID" value="JCM18909_2268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="23355" checksum="749AC9192BDA1582" modified="2014-03-19" version="1">MAAEYARPRAEFSDLVEMMARLRDECPWDRSQTHRSLVTYLVEETGEVIDAIEAGTDDDLVEELGDLLLQVVFHSRIGEQGGRFDINEVVGGIVAKLVARHPYVFSDEEVPEDLDAAWEARKAAAKGRTSSLDGIAHSLSSVARSAKVISRARTRGVGVKLADEPITAAEIGDQLVTLIARAQASGVDADQALRDRLRDLEDEIRKAEWRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS4</accession>
    <name>W4TLS4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Twin-arginine translocation protein TatC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69910">
        <property type="protein sequence ID" value="GAE69910"/>
        <property type="gene ID" value="JCM18909_3177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12667" checksum="678F1A27EFC18AB7" modified="2014-03-19" version="1">MVITSSVAFVFYRPLVEIVMHPYQQASLAIKAKNPTASLQVVNTGVVAPFVLNMRVAIVAGLIAACPIWLYQVWAFIVPGLLVNEKKWALRFLGSAIPLFLLGSVLGYWVLPKGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ9</accession>
    <name>W4TLZ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69418">
        <property type="protein sequence ID" value="GAE69418"/>
        <property type="gene ID" value="JCM18909_2628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="4948" checksum="2606462A6693D12E" modified="2014-03-19" version="1">MSYDVEKIRKDFPILSTRVGDYPLTYLDSANTSQKNPRLSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM00</accession>
    <name>W4TM00_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69552">
        <property type="protein sequence ID" value="GAE69552"/>
        <property type="gene ID" value="JCM18909_2781"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="342" mass="37567" checksum="B9183E24BC92D606" modified="2014-03-19" version="1">MSKVITQLPVGERVGIAFSGGLDTSVAVAWMRENGAVPCTYTADIGQYDEPDIASVPGRALDYGAEISRLVDCKAALVEEGLSAIACGAFNVRSAGRPYFNTTPIGRAVTGTLLVRAMHTDDVSIWGDGSTYKGNDIERFYRYGLLANPQLRIYKPWLDEHFVAELGGRDEMSAWLTAHNLPYRDSKEKAYSTDANIWGATHEAKKLESLHTSIESVNPIMGVKFWDPDVKIDTEEVTVSFEQGLPVAINGKEYDDKVALVLEANAIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLANAIHNEDTLETYHNEGRRLGRLLYEDVGSTRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM02</accession>
    <name>W4TM02_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69557">
        <property type="protein sequence ID" value="GAE69557"/>
        <property type="gene ID" value="JCM18909_2786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16529" checksum="610E08DE11B264D9" modified="2014-03-19" version="1">MDRHRDDETAPHPGLPARRDFFVGVAVGTCVGANVIREESGLVAVTMLGIYLANQRNLELEPVIEFKEHLQVLLVGVLFIMLAGRVTPSQILDILSAGLIFVALLVLVIRPASVLLGLVGTETTRQERTLMSFMAPRGIVAASVASIFCHAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM92</accession>
    <name>W4TM92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70100">
        <property type="protein sequence ID" value="GAE70100"/>
        <property type="gene ID" value="JCM18909_3390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10422" checksum="7EA424A832412D9C" modified="2014-03-19" version="1">MTPTPTPSPRTPVATHDSEESPDGRIPKASSSPIPTAQRSVLDAFGGRKPILIFAGVIGVLLLGVLLGSLTRRRGGNVHSSDEGDGNSFFDDWDSPDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA3</accession>
    <name>W4TMA3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein JCM18909_2907</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69662">
        <property type="protein sequence ID" value="GAE69662"/>
        <property type="gene ID" value="JCM18909_2907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15651" checksum="9F9BEFD4D8DA51D9" modified="2014-03-19" version="1">MPISSHDVGRTYPTTDPYLVTAEKIRELATALGDNAPAYRGDDPIAPPTFAMVLASRAWEALFDDEQLGLRLEHMIHTDQSFHWIRPLHEGDEVTAALTITSVRTRGNTDIIGINVSLDHVDGEHLGNATSTLWHTRPEGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK9</accession>
    <name>W4TMK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69782">
        <property type="protein sequence ID" value="GAE69782"/>
        <property type="gene ID" value="JCM18909_3034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="21741" checksum="29912559F65C70EA" modified="2014-03-19" version="1">MSFVQALQAVLIAIVLVGWIAYLVPMVVNRRRSQEVTDDKHEDFPDTMSVVSRGSCTVTPNDTDENPQVELSTPYTRSYARWELRRSWAVAARRRMTTMLVLLGLTVLSMVLAITDVTPWWLVAIFVLLLVGFFALARWSVVAMAKRFDRRYALIDKDGTRTRWRWRWVRNPFAPRTIPPPGRSTSTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM6</accession>
    <name>W4TMM6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69797">
        <property type="protein sequence ID" value="GAE69797"/>
        <property type="gene ID" value="JCM18909_3052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849151" evidence="1">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11447" checksum="D05DDCB63864F212" modified="2014-03-19" version="1">MNLSRRHLLSGGFAGLGVLGVSALTGCSTSTEPKSDTGAGDAKKLVLWMWPEGFDKQTLAAVAKAQPSYNVRQDIIGGDFKQKLTTTFTAGSGLPDLTGVKGEDIVFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ2</accession>
    <name>W4TMQ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69822">
        <property type="protein sequence ID" value="GAE69822"/>
        <property type="gene ID" value="JCM18909_3078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7362" checksum="6DE5A89DE2EA6AE2" modified="2014-03-19" version="1">MTKEVAMKHVNTVASVVLPMIAGISPLVEKRDERGLSQSTENAILLVGAVSIATVVVTVIKGYVSSNLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS2</accession>
    <name>W4TMS2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multimodular transpeptidase-transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70011">
        <property type="protein sequence ID" value="GAE70011"/>
        <property type="gene ID" value="JCM18909_3290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="561"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="815" mass="87497" checksum="485EE481BAC8465C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT6</accession>
    <name>W4TMT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69494">
        <property type="protein sequence ID" value="GAE69494"/>
        <property type="gene ID" value="JCM18909_2715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="4821" checksum="5CBAA870C8FFA039" modified="2014-03-19" version="1">MTPQRLDSAALAHALGASHRRVSPDDLQFLDEPVVGRQVVSVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMV6</accession>
    <name>W4TMV6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69519">
        <property type="protein sequence ID" value="GAE69519"/>
        <property type="gene ID" value="JCM18909_2744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6018" checksum="50A3F95FAB77CFBA" modified="2014-03-19" version="1">MKSDPKRVDHEVEVVLGDRDPNFKTTASKSVKVNGSVCLPSPSPTPSILASPGEQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMW3</accession>
    <name>W4TMW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70056">
        <property type="protein sequence ID" value="GAE70056"/>
        <property type="gene ID" value="JCM18909_3340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6112" checksum="3F5B1A3A192FD42D" modified="2014-03-19" version="1">MSDEKKVTHPGPDNPEAIHWTAGDARRTFHEKGEERLIHVRSLIANGRQRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX9</accession>
    <name>W4TMX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3644</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70330">
        <property type="protein sequence ID" value="GAE70330"/>
        <property type="gene ID" value="JCM18909_3644"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14974" checksum="5E0135AAA6AD0D2D" modified="2014-03-19" version="1">MLDIRPAATQMLKGMSHPAGDGAEVYDVTFENVQAGLRYDYLFRIANQRGGIVLGTGDLSELALGWCTFGVGDQMSHYGSIPGYPRPSFSTSFGGAFRRASLTRPLMWCSSRCWGQKSPPSSSPLVPARRSSPLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN59</accession>
    <name>W4TN59_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69644">
        <property type="protein sequence ID" value="GAE69644"/>
        <property type="gene ID" value="JCM18909_2887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="PTHR11733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M13_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="222" mass="24851" checksum="F5FC1A93D1E8DE56" modified="2014-03-19" version="1">MGQAGLGLPDEAYYRDDDKAEVREAYVGHVTRMFALAGLDNAADQAGAVMDLETEIASHHWDQVRCRDMKAAFNPKTFSELSSTHPGLHLDLWREGARIPVDVLATIVDNQPSFFDEVEPMMIDQRLDQWKAWARWHAISSLAPYLSSAFVNEDFDFFTVASLTAPLRSRLDGSAASRSLNRPWARPSANSMSLGISLQQPKSGWTTSSPTYWRHTVSPSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB5</accession>
    <name>W4TNB5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70440">
        <property type="protein sequence ID" value="GAE70440"/>
        <property type="gene ID" value="JCM18909_3758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5716" checksum="EAEA8EAA7C7EA05A" modified="2014-03-19" version="1">MGITVNSLMFRKRHTRVELGRALGVTPAAAGRKLRGEIGGLSATYSMLPNFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNE1</accession>
    <name>W4TNE1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translation elongation factor LepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69734">
        <property type="protein sequence ID" value="GAE69734"/>
        <property type="gene ID" value="JCM18909_2983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29678" checksum="C0CC325072790894" modified="2014-03-19" version="1">MMSTGAAHEVLEIGVISPEMVPAQGLSVGEVGYLITGVKDVRQSRVGDTVTNASKPSEKDLGGYQHPKPMVYSGLFPIDAKDFPDLRDALDKLQLNDAALVYEPETSTALGFGFRVGFLGLLHMEIVRERLEREFDLDLISTAPSVVHHVLMEDGSTVTVTNPSEYPTSGRIARCVNPSLTPPFSVLPSTSAPSLSCVSNVVVFSKAWIICRLIEWKSGIVCRSRRSFSTSLTSSSRVLKGMLRWIITKPVSRLSTSLRSTFCSTEIRWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH2</accession>
    <name>W4TNH2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69933">
        <property type="protein sequence ID" value="GAE69933"/>
        <property type="gene ID" value="JCM18909_3202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="22506" checksum="A2304A2613796720" modified="2014-03-19" version="1">MIRSVRIRGLGVIDETVLEPSSALTAVTGETGAGKTMVVTGIGLLLGDKADTGLVRHGCDRAVVEAVLDTPDAGRVSELGGTVEDGEVICARHITSRRSRALLGGAQVTASQLAHIVGDQVTIHGQSEQVRLVDAARQLDVVDRAAGDELAGHLSRHAQLWSEFRAASQRLQRLNEDRAGAEMEREVLTRRVGEVDAVDPKPHEDDDSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ6</accession>
    <name>W4TNJ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69963">
        <property type="protein sequence ID" value="GAE69963"/>
        <property type="gene ID" value="JCM18909_3236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5315" checksum="1589A61835F7F772" modified="2014-03-19" version="1">MVASAGCCQATSIKCGFFVVGMIVGFAASVYLIVKRYGIVPDQNNDREGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNQ6</accession>
    <name>W4TNQ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70595">
        <property type="protein sequence ID" value="GAE70595"/>
        <property type="gene ID" value="JCM18909_3945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5974" checksum="B035476611005EBB" modified="2014-03-19" version="1">MMVRGFLCICIPSQLRWRPDDVLSQQHDMLSGWFKLLPIFLMVLPVSSPGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY6</accession>
    <name>W4TNY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70257">
        <property type="protein sequence ID" value="GAE70257"/>
        <property type="gene ID" value="JCM18909_3560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="14252" checksum="47ECA602F4AFD03D" modified="2014-03-19" version="1">MYRAVWNTVKGSMGNLVEWFDVYTYTTFAAYFEDQFFSPDDPHKSIYIYAIFWATFIMRPFGSWFFGRWADRHGRRSALIMAVTIMPSAPSSSPCCPPEAPSEWGPDPVAHLSYRARIRHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPD2</accession>
    <name>W4TPD2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70268">
        <property type="protein sequence ID" value="GAE70268"/>
        <property type="gene ID" value="JCM18909_3572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="344" mass="35779" checksum="B9F79B7CC294E0AB" modified="2014-03-19" version="1">MEAYDKFVSQARHHNADAPIAVVVAGPPSESADHAAELTRIVASRWVDANILTIYLDGPGTAPMMGDPATPLWAEDESFQLPDNLDALAGIIVGGGAVPSYINGLAPAAEQLSMLVRGGAPWLGFSAGAMAPCVTALAGGWKLQGRQVGQQTGAESFDEVTFVEGLGLVSLTISTHNDTLSGDGLIISAVESGLLSSAVAVDEATCLRIDASTGHTEVMGRGLARWFTREVNGVLVRSQRSVTPETAPAPHKPRFDGLAKVAAATRAAHDKEERAKAARQRAEERRRARKSKSADDETKTSEGSATPEDAPASAANPQAAADPTPTAGPEPDPTAQPPTEDVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPD5</accession>
    <name>W4TPD5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70581">
        <property type="protein sequence ID" value="GAE70581"/>
        <property type="gene ID" value="JCM18909_3931"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17966" checksum="2649F89D5A5CD8F3" modified="2014-03-19" version="1">MHVSGMPWRIVAALAGVSPTSMHRLLFGRNGRPVEWIGINDARALMDIGIDDLASASTDRIPARESRELLVALHTLGWTDEHLSRWLTSSDLDLATTPKALYVTRLSAARIQATYDMLISQPVRRCGHPRTPPISSQTPVTSPQPGPEDAETFQPALFELADCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPG2</accession>
    <name>W4TPG2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="8" type="ORF">JCM18909_3720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70402">
        <property type="protein sequence ID" value="GAE70402"/>
        <property type="gene ID" value="JCM18909_3720"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="88"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="202"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="218" mass="23983" checksum="2C92DD47CF6785A6" modified="2014-03-19" version="1">MTRARSCFFEGAQAHHLDVDFGTYPYVTSSNPIAAGACTGSGVGPTRIDRIVGIAKAYTTRVGEGPFPTELCDDDGERLRTEGGEYGVTTKRPRRCGWFDALVVQQAVMINSVTDLFLTKLDVLTGWERIPVCVGYDIDDERTDVMPVTQSDLHHAKPVYEFLDGWSEDISTARSFDDLPRNCQAYVRRLEELVGTRVSGIGVGAGRDESVVINDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPH8</accession>
    <name>W4TPH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70636">
        <property type="protein sequence ID" value="GAE70636"/>
        <property type="gene ID" value="JCM18909_3996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40588">
        <property type="entry name" value="PTHR40588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006156">
        <property type="entry name" value="YafQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7844" checksum="8B535790B33F29A1" modified="2014-03-19" version="1">MNTLKTAIQAISERRTDWLKQHRDHQLTGNLTAYRELHIASDWLLLYTINNDNTLTLVRTGTHDQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPL7</accession>
    <name>W4TPL7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000065">
        <property type="protein sequence ID" value="GAE70681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70681">
        <property type="protein sequence ID" value="GAE70681"/>
        <property type="gene ID" value="JCM18909_4057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9988" checksum="83B96691751E289A" modified="2014-03-19" version="1">MVVVDIKGKIIEGDWGPSSDTASHLYVYRRRDDIRSIVHTHSTFATAWAATGQGIPCSLTAVADEFGGPVPCADYAHIGTEQIGQQVIRFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPN3</accession>
    <name>W4TPN3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70184">
        <property type="protein sequence ID" value="GAE70184"/>
        <property type="gene ID" value="JCM18909_3482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035214">
        <property type="entry name" value="DUF5324"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17258">
        <property type="entry name" value="DUF5324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="328" mass="34409" checksum="2A7F8FAF55105307" modified="2014-03-19" version="1">MSCKKKASRKTAAASSPSTLKEQRAQALETAAAYLAAAQDKAAPLAAQVNDKLGPLTEQISDKLGPLSDQAVEASKKKAFDASKEYTQEKVVPALHQAYDTFQKDVLPDLEERAEKVISHPAVEEATRRGQAAFSALKGESTELAAKAGIETKSVKKAKHRSKFGKVFGTLAVLGGISAAVVVASRRFLSSSDDGWTAHEPKVTYSWTPGDKDNTDSPAPNTDEKLKDTPSPKPETSHGSKPVAKPADKPKPKEDKSVPADPVAAMADEGGPAAAAPETTAETTAFVDEGARSETTTKDGAVKAPEQGTKDEGNKATSYVGDNPPEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPQ0</accession>
    <name>W4TPQ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70497">
        <property type="protein sequence ID" value="GAE70497"/>
        <property type="gene ID" value="JCM18909_3824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8500" checksum="9B4826834F1B02ED" modified="2014-03-19" version="1">MFDVPTRLDPQVHFAVFVHQRLPLSTTNAVRRKLSEDPRTDRHVMSVRLRMEMWHGPSLSRWKRKCPFRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPS5</accession>
    <name>W4TPS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cystathionine beta-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70527">
        <property type="protein sequence ID" value="GAE70527"/>
        <property type="gene ID" value="JCM18909_3860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7315" checksum="97C1BFC1A623FC89" modified="2014-03-19" version="1">MLAAFDALRDKIPEGSRVVIIAPDLGERYLDGVYNDDWVMENFGESAFNYAIRPVAHEVKETEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPX9</accession>
    <name>W4TPX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70433">
        <property type="protein sequence ID" value="GAE70433"/>
        <property type="gene ID" value="JCM18909_3751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="269" mass="28932" checksum="8F33992B16877921" modified="2014-03-19" version="1">MPLLEVNDLVVDFGRHRRVAVDHVSWSLDAGERLGLIGESGSGKSVTALAIMGLLPGNAHVSGSVRWRGKELLGASDHAMSALRGGSIGMVFQEPMTALDPTMKVGRQVGEVPLLHRTVTRGHARGRVLEMLEQVGIEDPARVMDSYPHQLSGGQRQRVLLAMALVNSPDLLICDEPTTALDVTVQSQVLATIDEVLDSVGAACLFITHDLAVVSHICRELIVMTSGKVVEAGSAREVLSHPDHPYTRRLLRAARLDLVEPGTTIALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQD0</accession>
    <name>W4TQD0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70429">
        <property type="protein sequence ID" value="GAE70429"/>
        <property type="gene ID" value="JCM18909_3747"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="2">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19115" checksum="D73027443F2D59D0" modified="2014-03-19" version="1">MMRPRSLFLNLSRGKVVDINALVDNLRTGHIAGAGVDVYPEEPASGKEPFISPLREMDNVILTPHIGGSTQEAQVDIGRYVAGKLIDYVENGATGMSVNIPEITPSPRTGARIGHLHRNVPGVMATLNRLVADQGGNVTYQALATKGELGYCILDIAETDSGLLANVTDLEGTIRARIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQH8</accession>
    <name>W4TQH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two component sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70484">
        <property type="protein sequence ID" value="GAE70484"/>
        <property type="gene ID" value="JCM18909_3811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="65"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17454" checksum="89FAE981681342DB" modified="2014-03-19" version="1">MLETIAETGREALLEMRRIVGVLRQDTDAEFSPSPSLAEIPDLVDKSGVKVELKVTGEEPVVSQALGLVVYRVVQEALTNVLKHAGPSAHATVTLAYSPTAIYVEILDDGYGAAVQGDGRGHGLQGMRERVTSMGGQLSAGPRKEDGFRVMAKLPVQADSRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQQ2</accession>
    <name>W4TQQ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000052">
        <property type="protein sequence ID" value="GAE70559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70559">
        <property type="protein sequence ID" value="GAE70559"/>
        <property type="gene ID" value="JCM18909_3901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6136" checksum="2D30AE99D5B0EFAF" modified="2014-03-19" version="1">MDAGCALSAVRRVCREVGRTFSMWSADLDAGSISEMLHLSSAREPIIGVSVLGKGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDL9</accession>
    <name>W4TDL9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_80</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67045">
        <property type="protein sequence ID" value="GAE67045"/>
        <property type="gene ID" value="JCM18909_80"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9480" checksum="69A94897DE8EB5A9" modified="2014-03-19" version="1">MAGKTVVLVDDVLFTGRTVRAALDALVDTGRPDRILLAVMVDRGHRELPVRADFVGKNIPTSLGEAVDVHVTEVDGEDSVTIRKVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDW9</accession>
    <name>W4TDW9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67155">
        <property type="protein sequence ID" value="GAE67155"/>
        <property type="gene ID" value="JCM18909_196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="4">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16947" checksum="574E7B4E27B53291" modified="2014-03-19" version="1">MDHEHTTTYDLQPHFVLTPEQWHERLSDEEYYVLREAGTEAPFVGEYTDTTTEGVYRCRACGAELFRSTQKFHSSCGWPSFYAPLAEDRVRYLNDESLPGRPRTEVRCAQCDSHLGHVFAGEGFDTPTDLRYCINSICLDLVPTDVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDY3</accession>
    <name>W4TDY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67170">
        <property type="protein sequence ID" value="GAE67170"/>
        <property type="gene ID" value="JCM18909_212"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5819" checksum="E971F3C10173D87F" modified="2014-03-19" version="1">MLWGIWNAFKFGLNGPVSLFRLVRAVMREQVMAQAVRPQDRMRVPTNSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEC7</accession>
    <name>W4TEC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67320">
        <property type="protein sequence ID" value="GAE67320"/>
        <property type="gene ID" value="JCM18909_367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4500" checksum="0C5209E6411AE24F" modified="2014-03-19" version="1">MSHSLSDVVWPLDDSTHVLPGHGGPTTMANERLTNPFLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEZ5</accession>
    <name>W4TEZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67097">
        <property type="protein sequence ID" value="GAE67097"/>
        <property type="gene ID" value="JCM18909_133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="297" mass="33066" checksum="3CCC4CC83119C17F" modified="2014-03-19" version="1">MRHGHPVHRPDGSRTDDAAVQPFLSGAISKTVNLPESSTVEDIAGVYMEGWKLGLKALAVYRDNCKVGQPLSEVKKKEEEEKAEPEVRIEYRPRRQRLPKSRMGRTTSFQVAGAGGYLTTGAYDSGRLGEIFLKLGKQGSTLPVLWTLFSIAVSIGLQYGVPLESFVQKFSNLKFEPAGMTDDPDIRISSSIIDYVFRRLALDYLDFDERAELVSTPLPSVLTTSKRGPTCLMRRMSLSTLRPSRTRRPTASGCMRTELTSPVFSQLRRRSSRLVKHTPVLSFSKSRSVVKLTPPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF15</accession>
    <name>W4TF15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Topoisomerase IV subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67117">
        <property type="protein sequence ID" value="GAE67117"/>
        <property type="gene ID" value="JCM18909_156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="35"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="15460" checksum="604AB66A9A5AD61B" modified="2014-03-19" version="1">MHTASTSREYGAKNLLVLEGLEAVRKRPAMYIGSTDTRGLMHCLWEIFDNGVDEALAGYGRRITVTLEKAGSILVTDEGRGIPVDVEPRTGLSGLEVVYTKLHAGGKFGGGAYNVSGGLHGVGASVVNAVSARLDVEVDRKSTVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF78</accession>
    <name>W4TF78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DinG family ATP-dependent helicase YoaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67083">
        <property type="protein sequence ID" value="GAE67083"/>
        <property type="gene ID" value="JCM18909_118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10208" checksum="82EF8A0EDA088B00" modified="2014-03-19" version="1">MQTQLAYKDIPTILDASEKVLSRRLRVAVLKGRNNHICLHKVRGGSTRTKGQDVLVPGADLVVAADDGREVEAAPESTLGAEVVMLREWAEKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFB0</accession>
    <name>W4TFB0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67655">
        <property type="protein sequence ID" value="GAE67655"/>
        <property type="gene ID" value="JCM18909_729"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20633" checksum="8297109F62F80E78" modified="2014-03-19" version="1">MSTKTTALLRTLKRCKERAMEDLDAAMREDPAATSKLMVAIAYQGVHAIWAHRLAHAMWIKKPALRPLARLLSQLSRHITGIEIHPGATIGRRFFIDHGMGVVIGETAVVGDDVLMYHQVTLGGRARGQFKRHPTIGNRVLIGAGAKIIGNITVGDDCKIGANALVVKDVAPGTVVIGIPSKVHQATSSPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFF1</accession>
    <name>W4TFF1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67491">
        <property type="protein sequence ID" value="GAE67491"/>
        <property type="gene ID" value="JCM18909_553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="27442" checksum="B69898581A10C58E" modified="2014-03-19" version="1">MKAAAQDQWKLLDLAQTDRRIAQAEHRRRTLPELAELKDLAVQRRTLAEEVVAKSTALSDAKMEQERIEGDLEPARARMERNQKTVDAGTITDHKALRGLTEEIEHLGRRISRLEDAELDAMQAVEDAERAHADADRRRIELDGHIRTVLASRDAGLKGIDDELGELRRVRQTQAGGIPTDLFKLYELLRERTGMGCAKLVHGVCEGCGIATNAADLRRYEAAGDDEVVRCEECDRILVRTGESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFH0</accession>
    <name>W4TFH0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67511">
        <property type="protein sequence ID" value="GAE67511"/>
        <property type="gene ID" value="JCM18909_575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="92"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="433" mass="48266" checksum="633F04068CC60C12" modified="2014-03-19" version="1">MEERNIRFVRLWFTDVLGSLKSVAIAPAEVEGAFVEGVGFDGSAIEGYARVYEADMVAHPDPATFQVLPWRSGTSTARMFCDITNPDGTSSAADPRHVLKRTMGRAAEMGFTFYVHPEIEFYLLNDEHHPGESPVALDNGGYFDHTTLGAGTDFRRDAINVLEQMGISVEFSHHEAAPGQHEIDLRYADALTMADNIMTFRVVIREIASLKGIKATFMPKPFTDHAGSGMHSHVSLFEGDTNAFYDAADEARMSPVAKYFVAGLLHHALEIIAVTNQWVNSYRRLSGGGEAPNYICWGRNNRSALVRIPMYKPDKASSARVELRSIDSAANPYLAYSLVLAAGLDGIEKELPLPEEASDDVWQLSARERHALGIKQLPQSLGAAIRCMEESELVAETLGEHVYDYFLRNKRAEFEEYNRQVSQFELDRYLPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFN4</accession>
    <name>W4TFN4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67248">
        <property type="protein sequence ID" value="GAE67248"/>
        <property type="gene ID" value="JCM18909_293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_N" evidence="6">
        <location>
            <begin position="7"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="337" mass="37424" checksum="BF4C72A035FB735E" modified="2014-03-19" version="1">MANYEPVVGLEVHVELSTATKMFCGCSTDTEKDPNTNVCPVCLGLPGSMPAINGHAVESAIRIGLALNCHIAQWCRMARKNYFYPDMTKNYQTSQYDEPICYDGWLDVEADDETFRVEIERAHMEEDAGKSLHVGGSDGRISGASHSLMDYNRAGVPLIEIVTKPIRGLGAKAPQVARAYMAQLRDIMIALSVSEARMERGNLRCDANASLMPRGSETLGTRTETKNVNSLRSVEGALRYEIQRQGYVLSEGRKVRQQTRMWQEAGEYTIAGRDKSDAEDYRYFPEPDLVPIAPSREWLSSCVPSCQSCQLPKKGPSVVPMAVLRSGHDLGRQRRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFN7</accession>
    <name>W4TFN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67342">
        <property type="protein sequence ID" value="GAE67342"/>
        <property type="gene ID" value="JCM18909_390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021229">
        <property type="entry name" value="DUF2800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10926">
        <property type="entry name" value="DUF2800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16524" checksum="077F471D71639D22" modified="2014-03-19" version="1">MLIAPSDHALLSASGAHRWLNCTPSARLESDESESTSNAAEQGTAAHALAEHKLRRALKQRSTRPVSPWIDDEMENLTNDYVAYVQEHISLAEETCGDPQVLIEQRLDFSHIVPGGFGTGDCVIIAEPKLQIIDLNTAWVYSLRLSVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX4</accession>
    <name>W4TFX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67338">
        <property type="protein sequence ID" value="GAE67338"/>
        <property type="gene ID" value="JCM18909_385"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849060" evidence="1">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="147" mass="17206" checksum="90B5E4EEF0F86D24" modified="2014-03-19" version="1">MIRLMRAMFRLAWTRKKHATAHRSIHNLPIEDLAPDATYDVMQMQAKLDDVKLVRRARDHMSIYESVVREEAKSLGEAGNLDFERMRDDIWDACRVLIDAGLSHDEVWARLTEWIDQHTQVDEYACGVVVSLLTQICELFKPRRQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG08</accession>
    <name>W4TG08_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67447">
        <property type="protein sequence ID" value="GAE67447"/>
        <property type="gene ID" value="JCM18909_508"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="424" mass="44511" checksum="BF6C5D93BA103067" modified="2014-03-19" version="1">MGKTPSTMMTGDPDMTRLVNNPDNFPSQAVAGLVSAFPNHLRPVFGGVVRAARTDRKVALVVGGGSGHYPAFAGWVGPGFADGAVCGNIFSSLSASQAYAVCKAADRGAGLLIGFGNYAGDVLHFGRAAERLRSEGIDVRCLLVTDDIASAPDHLKRRGIAGDLPVFKVTAAACEEGRGIDEVVAIFDRVNDRTRSLGVAFAGCTLPGVDEPLFRVEAGQMGVGMGIHGEPGIHDETLGTADEVAAMLVNRLLADRPENPGTRVVPIVNGLGSTKYEELFVLWNDISRHLETAGLAIVDPQVGEFVTSLDMAGVSLTLVWLDDVIEPLWLAACDTPAYRRGTVGQVDFDTAPLPQEVERVMVAHPGSRASRGLAGVIVEALEMVATRLSERSSELGRLDSVAGDGDHGIGMNVGPGLPSLRHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG93</accession>
    <name>W4TG93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67552">
        <property type="protein sequence ID" value="GAE67552"/>
        <property type="gene ID" value="JCM18909_619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="4894" checksum="39B7BFE4841E3F70" modified="2014-03-19" version="1">MTGTNIVNADRISKSWGTRTVLSEVSLGLSTGDVIGVVGRNGDGKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB0</accession>
    <name>W4TGB0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH merR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67189">
        <property type="protein sequence ID" value="GAE67189"/>
        <property type="gene ID" value="JCM18909_232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13656" checksum="DF7492F53B7E6D33" modified="2014-03-19" version="1">MPRSVRTIGQVMKTLKPDFPDLSISKIRFLESEGLLSPERAPSGYRKYSDSDVERLRYILTCQRDHFQPLRVIRDHLEMMDRGEEPPVSEAPPLPTENEGTPDPQPQPTGQGIVRTVALSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG2</accession>
    <name>W4TGG2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68045">
        <property type="protein sequence ID" value="GAE68045"/>
        <property type="gene ID" value="JCM18909_1152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6415" checksum="5A7DB07E06260BCF" modified="2014-03-19" version="1">MPESMIVDVDANEDLRSRWGDHVPVIFVDGTLISYWTLDADTFLSALRDGPSLPAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL8</accession>
    <name>W4TGL8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="5" type="ORF">JCM18909_1225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TGL8"/>
    <dbReference type="EnsemblBacteria" id="GAE68110">
        <property type="protein sequence ID" value="GAE68110"/>
        <property type="gene ID" value="JCM18909_1225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6937" checksum="5C6A29CAA9FB40EE" modified="2014-03-19" version="1">MAAVCDICAKRPGFGHNVPWSKKKTNRRWSPNIQRVRVVENGTHKRMNVCTSCLKAGRVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS8</accession>
    <name>W4TGS8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67737">
        <property type="protein sequence ID" value="GAE67737"/>
        <property type="gene ID" value="JCM18909_817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17045" checksum="63FCA3D19393DD0D" modified="2014-03-19" version="1">MALDCYDRAKTLMAQDKSTRSIPLVTETLEEGRHAIACVQARANGEPIPEVRPPCFFDPAHGPSTTDVMYSPDGGVARKVPACAADAQRVQQGRSPWIRTVDVNGAQLPYWQAGPDYAPWVQGYYRRYESDPVISGLAVGGLGLVGLGLFSALFDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS9</accession>
    <name>W4TGS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67966">
        <property type="protein sequence ID" value="GAE67966"/>
        <property type="gene ID" value="JCM18909_1068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="1">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4513" checksum="83B7301C84C522C9" modified="2014-03-19" version="1">MALRTPTFANVQVLEVVLPGTRVDDVEATIASLGWTLGDLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH56</accession>
    <name>W4TH56_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain heme biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67763">
        <property type="protein sequence ID" value="GAE67763"/>
        <property type="gene ID" value="JCM18909_846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="329" mass="36258" checksum="2480B475CB58EB06" modified="2014-03-19" version="1">MLILTGGDCFERPDLVDLIEYAVSKGLHVSISPSVTPLFTRDRVRAVQEAGVSMMSMSLDGGSATTHDAFRGFPGTFDHTVEACHMLRELGMKFQLNTVFTAKNIHEAPQMLKNAIDLGAMMFYTFMLVPTGRGAQLDMLSPLEREDVLYWLHDNSTRIAIKTTEAPQYRRIAFQRDAVRQGKERPVRHGELYEWLTRETNELLGETITEPRPPRTPLAINSGSGFAFIDHTGDVYPSGFLPIHCGSIKETPFPEIYRGSPVFQGLRNPNGFSGKCGACNFNHFCGGSRSTAYALTGDYLASDPSCAYVPPGYDGELPEGVPAEGIPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH96</accession>
    <name>W4TH96_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67892">
        <property type="protein sequence ID" value="GAE67892"/>
        <property type="gene ID" value="JCM18909_984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19934" checksum="5E4316BBA4355FB5" modified="2014-03-19" version="1">MGVNSTVPLVHYGSATTTLIIVNVVLIICAIAGNICGYWIGYLVGPKLFREREGFMGKVFSPKHVDTTHEFFRKHGSVALILARFVPIVRTFVTMIAGVGRMTFQKKFITYTAIGGILWVLVAVQAGYFLGQIPVVRNNFEAALLLIIVVSVLPMGVEWLKARRKGQVSQPQSARRSRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM4</accession>
    <name>W4THM4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Riboflavin synthase eubacterial/eukaryotic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67679">
        <property type="protein sequence ID" value="GAE67679"/>
        <property type="gene ID" value="JCM18909_757"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4366" checksum="E81D653FD2F1E004" modified="2014-03-19" version="1">MSRTPGDHWEVFRFALPAALSRYVVEKKDRLRSTAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM5</accession>
    <name>W4THM5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67913">
        <property type="protein sequence ID" value="GAE67913"/>
        <property type="gene ID" value="JCM18909_1008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="309" mass="34275" checksum="6AC75A36CCC0FE1A" modified="2014-03-19" version="1">MTADDVVFSYDRVMDPKNNSLYSQFTDFVIDSITKKDESTVVIKLKFPFEELLANRLATFKVVPKVIVEKDQKKFDANPVGTGPWKMTANGSGGSLKFARNEHYNGPRPAKAAKMVWNIMPDPDARTNALTSGSVQAIDSLPYTKIPNMKSSGFEYSSEQGFGLAFAMFNCSAGNPFNNVKNRQAVMYAMDVAKACKVGLSGQATPATCFVQAGHPAYQKAKVVYDRDLDKAKTLFRETGLKKFRVLGTDHDWMKAVENILVDSLKEADVVVEFDQKQSADVYNEITGKPEAYDVVLAPGDPSVFWRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR6</accession>
    <name>W4THR6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Germane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68057">
        <property type="protein sequence ID" value="GAE68057"/>
        <property type="gene ID" value="JCM18909_1166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="7">
        <location>
            <begin position="288"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="487" mass="52876" checksum="30771885992DC61F" modified="2014-03-19" version="1">MPESDMTGSFSESRDDWLPQLYQERWDAFVRLATLLLADQQVAEDAVIAAFATSYLRDPKLHSYEHAVSYVRTAVVNKARSRQPAERDATPPETPEDLAYWCLRGLLARQREVLVLKLATPDLSDDDIAETLGMSVSAVRNNETKGLIAIGERLRPGSQTNPGHADPRVEAVVRSALETFAESIHPMSRYDAIISQIARRPHRGRPTTWVIVLACGLAFLVGVLLPLLGSGNGSTMGDPEALPSIRTPESNSQSLSTLQTDLDVFYLGRDDGLIHRELRDLPTSGDRLGTAVGAVLNVAPLDPNYTSGWAAGQVNRATVKGNRITLDLSASAFSQFKNGEQVQRAIQQLVVTATAAVGDRTGDKSVRILVDGSPNLPIIGKPATDFVDEGFARCARVWVDSPQAGADMSAGTITISGVAQPTVSVMSYEVRPPQSSRIITSGQINLSANDGDKWRPWHATFTMPKGEYDLIIREGTHIADEKVITAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT4</accession>
    <name>W4THT4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67978">
        <property type="protein sequence ID" value="GAE67978"/>
        <property type="gene ID" value="JCM18909_1081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010374">
        <property type="entry name" value="DUF969"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06149">
        <property type="entry name" value="DUF969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="25568" checksum="39AEE645F275F50B" modified="2014-03-19" version="1">MWVLLAVAIVVVGFALRLNAMLVVAVAGITAGLIAGMSPVKIIETFGTGFASSRSVTVFIVVLPVIGLLERHGLMQQAGRLMSKMKSMTAGKLLAVYLAVRQITAAVGLSSIGGPAQAVRPLVVPMAEAAARRTHPRYTRKMREKLRSYASSADTIGLFFGEDVFIAIGSILLITGFVDATYNLKLELSKSPCGPFRRPFAPSSSMHLDCGCWITNSPRWLPREATTSTSMRSLSLATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI11</accession>
    <name>W4TI11_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dipeptide transport ATP-binding protein DppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67804">
        <property type="protein sequence ID" value="GAE67804"/>
        <property type="gene ID" value="JCM18909_889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="23780" checksum="A0986EAC64EE404C" modified="2014-03-19" version="1">MSVSQPEDILLRLQDLEVTIDVRGGRVTPLRGCSMEVRRGETIGLVGESGSGKTMTALSIMGLLPHGGRVTGGSIVFNGRDLTSSPPDETRRIRGMDIGMIFQDPLTSLNPTMKIGNQVGEALRIHKVASKKKAWERSIDLLRKVGMPRPEKIVNDYPHQLSGGMRQRVMIAMALICSPSLLIADEPTTALDVTTQRQILDLIDDLKKRSSTPPLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI87</accession>
    <name>W4TI87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate-dihydroxyacetone phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68247">
        <property type="protein sequence ID" value="GAE68247"/>
        <property type="gene ID" value="JCM18909_1370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="3983" checksum="9B3E1EBD7B09D7DE" modified="2014-03-19" version="1">MTSLEMAGCSLTLLSADDDLLTLWDAPVETPGLRWGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE1</accession>
    <name>W4TIE1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA:pyruvate transcarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67904">
        <property type="protein sequence ID" value="GAE67904"/>
        <property type="gene ID" value="JCM18909_998"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="307" mass="32675" checksum="7C0E54EB09068F47" modified="2014-03-19" version="1">MAEKKPIKLADTMAGRIEQLADERHAVELGGGEDRLQKQRDRGKQTARERIDNLVDAYSFDEVGAFRKHRTTLFGMDKAEVPADGVVTGRATIHGRPVHIASQDFTVMGGSAGETQSTKVVETMEQSLLTGTPFLFFYDSGGARIQEGIDSLSGYGKMFYANVKLSGVVPQIAIIAGPCAGGASYSPALTDFIIMTKKAHMFITGPGVIKSVTGEEVTADDLGGADAHMSTSGNIHFVAEDDDAAVLIAQKLLSFLPQNNTEDAQISNPNDDVSPQPELRDIVPLDGKKRATTSATSSPRSSTGATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE8</accession>
    <name>W4TIE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68208">
        <property type="protein sequence ID" value="GAE68208"/>
        <property type="gene ID" value="JCM18909_1330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="35"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="286" mass="30350" checksum="89C5AA6EEB7A3873" modified="2014-03-19" version="1">MEAIIAEHKDELVADVIVVADSVNWEQGVPSVTTTLRGVVDCIVEVSTLDHALHSGQFGGIVPDALTTLCRLIATLHDGTGEVTADGLQGFAGPDLDYPEDRLRAETGILDGVQWVGRGRAVEKMWTKPSVTVIAIDATPVKDAINILPASARAKISLRVAPGQDAGEAMEALVKHLESHVEFGAHIKVTRGQLGQPGVVPFTGDKAEVAKEAFRLAWGQEPIEMGTGGAIPLVTDLQHAFPEATVLVTAVTDPESRMHGIDESLHLGDFRRAILTEALMLAGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG6</accession>
    <name>W4TIG6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GTP-binding protein TypA/BipA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67909">
        <property type="protein sequence ID" value="GAE67909"/>
        <property type="gene ID" value="JCM18909_1003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13639" checksum="B04902D6D79EDD0C" modified="2014-03-19" version="1">MVADRQGVVTSYALFNLQERGTMFVSPGEDTYEGMVVGENSRPDDMDVNPTKEKHLTNVRSSTGDELERLIPATKLSMEQQLEFCREDECLEVTPDVVRIRKTELNAHERAKARTRAKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIM0</accession>
    <name>W4TIM0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68631">
        <property type="protein sequence ID" value="GAE68631"/>
        <property type="gene ID" value="JCM18909_1779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="433" mass="47224" checksum="ACC618D26C2DF0A8" modified="2014-03-19" version="1">MRGPIWTLRNGLYAKVAGTRRPGQTALLEDIAVPVENLAAVCEDLQQLFSEHNYPESIIFGHAKDGNIHFLVVEDFRDKAGLDRYEKKFTEDMVTLVLNTHGTLKAEHGTGRIMRPSSHVNTGLTFTESCVRSKKSVDPAGVLNRGTIITDDPKLHLKEVKLTPTVQDEVDRCVECGYCEPVCPSRDLTLTPRQRIVMQRAIAQARADGDEELATDLEKRATYPVVQTCAVDGMCQTNCPVHINTGDLVRRLRAEHNPAAWQATWISRLRGGEPFVTAASAGMSAIKPVPAAATNVLTGAARAVLGADRIPQVSDELPGGGKRRSSGHRSAPHGRPEVVYLPACVNTMFGGVMPGKKTTEFAIISLLTAAGIGVTVPEGINSLCCGTPWKSKGMTQGYATMRRRVVDIMRQATRDGDLRRGELFGRLRPRARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIR5</accession>
    <name>W4TIR5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraZ</name>
        <name evidence="10" type="ORF">JCM18909_1832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68681">
        <property type="protein sequence ID" value="GAE68681"/>
        <property type="gene ID" value="JCM18909_1832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10409" checksum="9B838AA640E224BE" modified="2014-03-19" version="1">MTREIAKGSVSVKKVRDYQRMLAAGASDTAPDKQGRVMIPPMLRRYAALNKEIVVVGAITRVEVWDATEWEKYSEAQEEAFADMNEEVFAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX4</accession>
    <name>W4TIX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68104">
        <property type="protein sequence ID" value="GAE68104"/>
        <property type="gene ID" value="JCM18909_1218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9737" checksum="46C9BC95D0C80AA6" modified="2014-03-19" version="1">MSVLGARVDVSITAVPGVEATSRRVTLSSPSASLDDIPIPDVLLKPILEGITSRFTLPYLGNLHYESLKATPQGLDFSLAGTEVKLSDLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ89</accession>
    <name>W4TJ89_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68468">
        <property type="protein sequence ID" value="GAE68468"/>
        <property type="gene ID" value="JCM18909_1607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004586">
        <property type="entry name" value="RecB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF23">
        <property type="entry name" value="PTHR11070:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="7">
        <location>
            <begin position="142"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="390" mass="43296" checksum="EBDD75D74EEB193A" modified="2014-03-19" version="1">MKYGEVPIFSKEDTETPAQDVLWALSVREDVRRRSKSRAVHTFDDLIGDLVKALRDPYRGPLACATLAHRFGLVMVDEFQDTDPLQWEILRRAFHGHSNLWLIGDPKQSIYAFRGADIHAYQDAAQSASHVLHLDVNYRTDKPIVEAVNTLFSNAQLGHGISMELVMAHHQESRIKTATTDGPRYHWSQPFQIRCLQAPAGAQLSTATSDQSVTEDLVNQVIMMLEGGTVVQDGDGLRPLHPNDIAILVRTRRRGAELATALSQAHQPAVFSGASPVWSSQAAEDLMTLLEALENTDERLRTRLCLSDLIGATPADLAASDSRVRSDLAIDLARWSSTWTMTGVWGTVEAALHRPGVLVRLVSMAGGERYVTDLRQVAQKKRILRPVKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE1</accession>
    <name>W4TJE1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68269">
        <property type="protein sequence ID" value="GAE68269"/>
        <property type="gene ID" value="JCM18909_1393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0874">Quinone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="6">
        <location>
            <begin position="159"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="441" mass="49006" checksum="EBACEDB165B640EC" modified="2014-03-19" version="1">MPSCHRRTSAGATTDERESRVLVPGRRLGQIVDEAAERGDETVVVNFGPSHPSTHGVMRLIIELDGESVSDLRVGIGFLHTGIEKNMEFRTWTQGVTFMTRCNYVANFFNELVYCLAVEKLLGITDDVPERARVLRVMITELNRISSHLIAVGTGGLELGASSVAEVGLREREIILEFNQAVTGLRMNNAWIRPGGVATDLPETGLDQLRDLIKRMEKYLPEIGQFCNENPIFKARTQGIGYADLSICMALGVTGPALRATGLPWDLRKTQPYCDYDTYDFDVATWDTCDCYGRFRIRLEEMDQSVRILKQCLKRLEDTQGDRHMVEDPHIAWPAELALGPDGQGNSNEHIRHIMGESMEALIHHFKIVTEASGCLLARCTRPLRGPAASSAVTLFLTVASGLTVPTCAIPDSSTCSPCPPCVRAECFLTWCRLWHPWTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJF5</accession>
    <name>W4TJF5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="2">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68672">
        <property type="protein sequence ID" value="GAE68672"/>
        <property type="gene ID" value="JCM18909_1823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="431" mass="46781" checksum="CEC0AD25D08A7BB8" modified="2014-03-19" version="1">MTDHAENRCGLEGPRSFSSRHVGSVEDDLRYIAETIGVTSPEQIIRDAIPASVLDSNEGDSSVRTPSFPPAADETTARAELVEIASGNRVTRALIGRGYYGTLTPPVIRRNILENPSWYTAYTPYQPEISQGRLEMLTIYQQLITDLTGLALANSSLLDEATAASEGMLLARRAARKVKSNRFLVHTHLFDQVRDVVLGHAEATGIEVVETDLRDPQSWRPEVEAGCFGVLAPYPDSTGALWNPFEVFDAVHTVGGITIAECDLLSLTLLAPPGELGADVAVGSSQRFGVPMGNGGPHAAYMSVRSGLERQIPGRLVGVSTDADGNPAYRLALQTREQHIRRDKATSNICTAQVLLAVVAAAYAVWHGPTGLTRIARQVTDRAHQLASALRAAGLDVADQQFFRHHPHTHEGRSEGAVEPSPRRWVHPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP6</accession>
    <name>W4TJP6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">THAP4_heme-bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69001">
        <property type="protein sequence ID" value="GAE69001"/>
        <property type="gene ID" value="JCM18909_2180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7442" checksum="C138D470BE55B8F3" modified="2014-03-19" version="1">MWTGNIDGAKIELVTDAVARTEEALVPYTGGQRLYGQVEGDLLWTFDRATVDAPLQPYMWARLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR0</accession>
    <name>W4TJR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68772">
        <property type="protein sequence ID" value="GAE68772"/>
        <property type="gene ID" value="JCM18909_1929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11622" checksum="CA93108E1AF18A76" modified="2014-03-19" version="1">MSKRVNAMRDFIVSHPWWCVLIVAAMFWIPRAGIWVAVGSWLAIIAVCAKHRALPAAKVSARVVSSGSSMELNVGDRVTRYDVFWNVLLRGSEIRCWVYGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV4</accession>
    <name>W4TJV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69071">
        <property type="protein sequence ID" value="GAE69071"/>
        <property type="gene ID" value="JCM18909_2255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5396" checksum="28B8353625A84D30" modified="2014-03-19" version="1">MNESGIAVSKVASFAGIIPGHLIVVHDEIDLDPGRYASKKREAEIMAIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJY1</accession>
    <name>W4TJY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68419">
        <property type="protein sequence ID" value="GAE68419"/>
        <property type="gene ID" value="JCM18909_1555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012551">
        <property type="entry name" value="DUF1707"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019109">
        <property type="entry name" value="DUF4870"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08044">
        <property type="entry name" value="DUF1707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09685">
        <property type="entry name" value="DUF4870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="200" mass="21587" checksum="560486190E663565" modified="2014-03-19" version="1">MNSWQMWQTGKDGWLVNDVDRDRVVALLRDAYVDGRLSPDDFDDRVTRALGAVTRADLNAALTGLAVVGGQAHGSRIAAGETLAAGVIGLSPFFLGPLGPMLGVAISPRGSWIRRQAAQQANFQLVALLLAMVVLGVAVKTNLMIVTFPFVGMAWFAGTIMHAAKAFEGIEWTNPLLRVIPLRFFDDGRRRAVGSVSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK04</accession>
    <name>W4TK04_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68763">
        <property type="protein sequence ID" value="GAE68763"/>
        <property type="gene ID" value="JCM18909_1920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2_2" evidence="1">
        <location>
            <begin position="51"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17066" checksum="E01E629CD9ED93C1" modified="2014-03-19" version="1">MWEFLASVDLIEMIKAPKVDPATPLPWAVEDPRVVKFTRHIDLGWLRILDVKKAMAVRGWDHQGSVTFHVVDPMGYAEGNWRVDVEAPGAPATVTKVDDSTDAATLDVAALGSLYFGMGRGFSLAAAHRITGTDEQIAAVDRMFSTVDVAHNISEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK79</accession>
    <name>W4TK79_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycerol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_1695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68549">
        <property type="protein sequence ID" value="GAE68549"/>
        <property type="gene ID" value="JCM18909_1695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="400" mass="44228" checksum="65EC17A955E95D35" modified="2014-03-19" version="1">MIFPGRPAVYACYENVEKIRDHMRDLDGVIACSIGSGTLNDITKRASDELGRRYMNVCTAASMDGYAAFGASITENGFKHTMSCRAPQALIADLPTMAGAPQRCTATGLGDLIEKVPAGADWIVADELGIEPIDDEVWDLVQGPLTSAISDPEGLANGKPEAFDGLIEGLVMSGLAMQKYRISSRPASGAGHQFSHLWEMEHLGMDQDPPLTHGFKVGLGTISVLALWERTLNHDFTALDVDAAVAKWPSAKEMEAKVRANFTGDMLEPAVRQTMDKYLDADALRERLELVKSTWPTIRERCRSQVMPAAKVEEIIKTVGGIYHPAQIGLTRERFHDTYYRCQMIRSRYTLLDLLVETGTIGDLVESLFEPDGFWGRRPWPQDWVPGRRRVGLTTRPSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKA6</accession>
    <name>W4TKA6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S41.006"/>
    <dbReference type="EnsemblBacteria" id="GAE69380">
        <property type="protein sequence ID" value="GAE69380"/>
        <property type="gene ID" value="JCM18909_2589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029414">
        <property type="entry name" value="Tricorn_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14685">
        <property type="entry name" value="Tricorn_PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="TSPc" evidence="7">
        <location>
            <begin position="41"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="22154" checksum="AE22EBB420C1BF04" modified="2014-03-19" version="1">MTEGDVIVAVDGRKVGADGNLGELLEGSAGRVVELTVHRGENERQVAVVPMADEAPLRYHDWVASRRRYVEEHSGGRLGYLHVPDMVSDGWAELHRQIGEATRHEGVIADVRFNHGGHTSQLVVERLARRVVGWDYSRWYATADTYPQNAVRGPIVMVTNQWAGSDGDIVAAATQAMGYAKVIGERSWGGVVGDRRQVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD9</accession>
    <name>W4TKD9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68619">
        <property type="protein sequence ID" value="GAE68619"/>
        <property type="gene ID" value="JCM18909_1766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="4845" checksum="4B5033862BD0DBDD" modified="2014-03-19" version="1">MATVGTVASVGIVWAILIAGKLDTLPWARGLQGTWESTSIGYGCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE6</accession>
    <name>W4TKE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69271">
        <property type="protein sequence ID" value="GAE69271"/>
        <property type="gene ID" value="JCM18909_2471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21656" checksum="6ED66F1073D503CE" modified="2014-03-19" version="1">MADDVDWQPGIVFTHTLSLTLDDKAQEILQGIRGQLMAVGVPVLHQPAHITVAAVSTMEGVDSHLVDVGWPERITLTKSCRLPNSDGVVGLCPHDPISSDPVTIFDTSSEGEPELCSAPPSAGSFRALTCLPEALRRLMSCCTGGWLRRGSSLSTITALDGGTPTSRWGIKFRPNYKSEPSELSLAWGLWKWGWQESQSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF7</accession>
    <name>W4TKF7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69281">
        <property type="protein sequence ID" value="GAE69281"/>
        <property type="gene ID" value="JCM18909_2481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="17373" checksum="3CCF436A408AF9BD" modified="2014-03-19" version="1">MALAAFHSDEILDDAELPKRYVAFSPCYRREAGSYGKDTRGIFRVHWFDKVEMFVYCLPQEAEAWHEKLLSFEKDFITALQIPFQVLDVASGDLGLSAARKFDCYGWLQPRTAIVRSPRRRTALPSRPGACLFAIADLTALNPWPLSTAPYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL5</accession>
    <name>W4TKL5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-70 region 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68953">
        <property type="protein sequence ID" value="GAE68953"/>
        <property type="gene ID" value="JCM18909_2130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="137"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21622" checksum="118C8BD898EF8DEF" modified="2014-03-19" version="1">MVSRVDGHGGDEVILADIRAAQDGDAGAYARIVKSWGGRLLRFCRNNLPATIDAEDVVQDVLLTAWQKLPGFDDRSRFRAWMYTIARNRCREVIRTAGRRATDPVSPEEVAVKIDSRQDPARLMPETQQWWRCEKSVAGLPDSQRRIWVMAQIDGLGYAEIADIEELPLSTVRGRLARARATIAKEMESWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM3</accession>
    <name>W4TKM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68709">
        <property type="protein sequence ID" value="GAE68709"/>
        <property type="gene ID" value="JCM18909_1861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8577" checksum="B521A06C37A445A1" modified="2014-03-19" version="1">MSFINPTVLVGGQLKCWRVVMVAIGVLGYGLDQWTKAEAVARLDPYDPPSWFGGFFTLRLIRNPGAAFFDGLDSHCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR9</accession>
    <name>W4TKR9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68754">
        <property type="protein sequence ID" value="GAE68754"/>
        <property type="gene ID" value="JCM18909_1911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5276" checksum="2ACAB8AADFBFC046" modified="2014-03-19" version="1">MVDDATHVANAVSVRVGEAAWVDLVDDSGLPLHQSLIVGEVVMGSLWGCVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA8</accession>
    <name>W4TLA8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-dependent repressor IdeR/DtxR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69765">
        <property type="protein sequence ID" value="GAE69765"/>
        <property type="gene ID" value="JCM18909_3016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe_dep_repr_C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16769" checksum="63BDE466D7EA361D" modified="2014-03-19" version="1">MRKHRLAECLLTQIIGLRPDLVHDEACRWEHVISGEVEKRLTGLLDNPDVSPYGCPLPPEQAGCRPDGSARFRDDSKPLDEVIADTGCPVSVTVTRLSEFFQATEGNLADVYAAGLLPGKSVEVDDDADGIRLTGPSGSIVVDPEILSGLFVAQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC5</accession>
    <name>W4TLC5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69327">
        <property type="protein sequence ID" value="GAE69327"/>
        <property type="gene ID" value="JCM18909_2531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7190" checksum="D2850E533F44833F" modified="2014-03-19" version="1">MIVVPGLRRMLNPSDPMRSRTLRTGIEVWSSDLNHVFFGLGSGRLWPWYLYDCHARQERGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD2</accession>
    <name>W4TLD2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Molybdenum cofactor biosynthesis protein MoaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_3042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69790">
        <property type="protein sequence ID" value="GAE69790"/>
        <property type="gene ID" value="JCM18909_3042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29559" checksum="28C9749B08EC2815" modified="2014-03-19" version="1">MRFTGGEPLLRPSLENLVAATSTLHRTNGTPPVTALTTNGIGLDRRVDGLVEAGLDRVNISLDTVDRERFATISRRDRLADVVTGIDAALAARLSVKINAVPQIDSYRRDIPELLVFCLDRGLELRFIEFMPIGANGWKREATVSADDILTVVRDAGFSITADQAARGSSPAQRWSVSSRHTRPGWLGIIASVTRPFCANCSRTRLTADGQIRNCLFADQEADLRSLLRSGASDDEIIAVWQGEMWCKSAHHGVDNGSFANSRRRMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK7</accession>
    <name>W4TLK7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongation factor Ts</fullName>
            <shortName evidence="4">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tsf</name>
        <name evidence="6" type="ORF">JCM18909_3128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EF-Ts family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69865">
        <property type="protein sequence ID" value="GAE69865"/>
        <property type="gene ID" value="JCM18909_3128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9827" checksum="E11C8E51B3ED760D" modified="2014-03-19" version="1">MSPRWLCRDEVPADVVEHERTVAADIAREEGKPEKIIDRIVEGRLGGFFKENCLLDQPAISDDKKTVAQTLEAAGVTLKRFVRFSAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL7</accession>
    <name>W4TLL7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69059">
        <property type="protein sequence ID" value="GAE69059"/>
        <property type="gene ID" value="JCM18909_2241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="1">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17369" checksum="EFC81781CD8BBBAE" modified="2014-03-19" version="1">MDDPFDLLRPMTVTVRVSAKVNLALGVGGLAPDGFHPLATVFEAICIYDEVAVTRRDDSRITLTVSGEDADQVPTDETNLAWRAVELVREEFASEWGKRGHGADIHIDKSIPVAGGMAGGSADAAGALMAAAALCRLPYSPEELQPLAAQLGSDVPSVSPVEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM7</accession>
    <name>W4TLM7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-Hacid_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69074">
        <property type="protein sequence ID" value="GAE69074"/>
        <property type="gene ID" value="JCM18909_2258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="1">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10112" checksum="A815EE45D49EE1A0" modified="2014-03-19" version="1">MLSEALAERGVKFLSTRSIGYDNIDIAAASAAGIRVSGILYSPKSVTECTLMMLLMTVRRMKLILDRGEIQDYSLEGSDGRHLSEMTVGITGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM13</accession>
    <name>W4TM13_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HisKA_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69433">
        <property type="protein sequence ID" value="GAE69433"/>
        <property type="gene ID" value="JCM18909_2647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="81"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30898" checksum="3D5BC17300CE15D3" modified="2014-03-19" version="1">MASQHGLKRHCIPLIIGATITVAMAAVHATHWVSRFVVACLACAIGIGVGSAFRWLDNRREQAEEQAADALQQAAHAREEERQQLAAELHDVVAKDLTVITMLAGSLRLNTADEDVITASKSIENTSRAALDDLQRLLLVLRNRNLPFISSPTHEDSVEATVAAMVTRLETLGWHVKSSVACAPMPVSVSDAVNRILDESTANVIKHNGPATARITVMDEGDDVVVTVSNPTTDPEIEPVRSTGMGIARLKERVSLLHGKISIGLRNGWWVVNARIPRAKPVRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM33</accession>
    <name>W4TM33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69458">
        <property type="protein sequence ID" value="GAE69458"/>
        <property type="gene ID" value="JCM18909_2674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7493" checksum="8907B2E928EB2177" modified="2014-03-19" version="1">MLWHLTGQAPMGTRTVLLRRDGRAVLSSVSAKKWSENRVTTSPSTFLGRNGDNDSEVSRQFWAAASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM58</accession>
    <name>W4TM58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribose ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70065">
        <property type="protein sequence ID" value="GAE70065"/>
        <property type="gene ID" value="JCM18909_3350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7987" checksum="424E32886F484DA2" modified="2014-03-19" version="1">MSLMPLQLSLLVEPHCQEVLGRQAALFIGAVLLAVIRNGFNILNVSSFWQQVVIGCVIALAVGFDVFRSKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM82</accession>
    <name>W4TM82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rare lipoprotein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69513">
        <property type="protein sequence ID" value="GAE69513"/>
        <property type="gene ID" value="JCM18909_2738"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849147" evidence="2">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9151" checksum="4F51FE5BD69D7536" modified="2014-03-19" version="1">MTNTSTNAGTTLKRTVALAAAASLAVMGTIAEEAHAAPVGNPGLMPKRLPPNTPRSTGRTGQTRHGVHRSVRAFSRPPQRPFWTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME0</accession>
    <name>W4TME0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peripla_BP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70150">
        <property type="protein sequence ID" value="GAE70150"/>
        <property type="gene ID" value="JCM18909_3446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="42"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21824" checksum="7ABD96A9781A1851" modified="2014-03-19" version="1">MSDAGLRHLAGIKPVMTVNRKVPGVSSVTPASDEGLGDALTHLVGDGRSTVTYLAGPTASWQSGVRWRSLLERARRDGKVTVHQLACPTPTIRGGIGAFDMWRLIRPPLSSPTTTHRDRIHASSNGPWLRIPHDVAVIGFDDIPFSALVSPALSTVRVNQFQMGVVAVNRLLDMVEKPNHHERQSPSEDVVPVSFMVRESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME1</accession>
    <name>W4TME1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiC transcription regulator-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69578">
        <property type="protein sequence ID" value="GAE69578"/>
        <property type="gene ID" value="JCM18909_2811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7156" checksum="136FB660CB974728" modified="2014-03-19" version="1">MLDWTVETAPPAVAAALGLPSNSEVTHFRRLRMSQDEPLAIMTNWVRGPRAQRRRAENHWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF2</accession>
    <name>W4TMF2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69369">
        <property type="protein sequence ID" value="GAE69369"/>
        <property type="gene ID" value="JCM18909_2578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10623" checksum="694FF1A7F37A915D" modified="2014-03-19" version="1">MNLLITAYPIHTWLVKHKCPRWISATTAGTAVIIVLAAGVVGMVWSVAAMINQLQSYIPQMEKIYTQLLHWSTQLGYSQDVIADKLKKRLIRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF5</accession>
    <name>W4TMF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c oxidase polypeptide 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70165">
        <property type="protein sequence ID" value="GAE70165"/>
        <property type="gene ID" value="JCM18909_3461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7736" checksum="B0BE8B104E55AAED" modified="2014-03-19" version="1">MKPERWVFGGLGLFYLVVTPVYWFTAHEVPVLGCSGCRRRWPDGVFSTSRSSPRRSILDPPTRRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG5</accession>
    <name>W4TMG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69608">
        <property type="protein sequence ID" value="GAE69608"/>
        <property type="gene ID" value="JCM18909_2845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17440" checksum="BBD7AC1D39A03E58" modified="2014-03-19" version="1">MAMCTEIMMVSKDGAHIYQHDPWLPNDYSFEASTPYNSRFRVHSMSASGSVALITNDHGDMFTRLWDYDIAGTDPAQFRYTWQDQSNLPSLPRGCRARSILATLPSSFHRPGGSISRRSPARSPTGLPWCQPLPDPRTGNFVSRDVVRAIPVTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML1</accession>
    <name>W4TML1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69663">
        <property type="protein sequence ID" value="GAE69663"/>
        <property type="gene ID" value="JCM18909_2908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9562" checksum="DA6322EFF21BC0EF" modified="2014-03-19" version="1">MDGVIAHGMWTMGAALGTVIDWVGGPERVVSQRARFTRPVQVPDTEGGTAIEVAATVRKVSEGAATLAVDVKCDGQSVLGWVEVVVRQGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR1</accession>
    <name>W4TMR1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="4">2.7.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69708">
        <property type="protein sequence ID" value="GAE69708"/>
        <property type="gene ID" value="JCM18909_2957"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12227" checksum="4B3F4C8B5B121F81" modified="2014-03-19" version="1">MASATQLVRHYGCVVAISGPVDHILDADRHVIVSSGHEWMTRVTGVGCSLGALTAAFAGIQNDHLIAAVSATAMLCVAAERAAERSAGPGAFAQALVDELFLVSPDEVGERGGLRDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS4</accession>
    <name>W4TMS4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69842">
        <property type="protein sequence ID" value="GAE69842"/>
        <property type="gene ID" value="JCM18909_3099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022434">
        <property type="entry name" value="ABC_LPXTG_lipo_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03772">
        <property type="entry name" value="anch_rpt_subst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848834" evidence="4">
        <location>
            <begin position="24"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="507" mass="54828" checksum="83EFF20ED981E4BE" modified="2014-03-19" version="1">MKKRLLRLVAALSLLAGCGHAPASRDKLSVVTTTPILADLTRQVAGDRATVTSMVPSGADPHTYEPSLRDVRTVVYSRVALSNYLMLEPHAVIKTIDSSLPTGSINVSLAEEAQRYGAQVIPLVENANLDTVWLGLRVIGKGARRGADRSSSVHLQLTSVEGPGDLTAYITGTFGRPQIYYSTADGIGERDDVELPTDAHTHMSWAFSKPGVYKAVFAATLSTPQGNTSFGAQTLTITVGTDPRTIPELADRTVVDQGHADLSADIDAGTMTILSDPTGGGVRTQKRLDPDKTVVWVPPKALTEIPPSPAFRFLGHPGSSIHQLPQAVLGAHVHGEIDPHLWMSIKNTKAYVQVIRDSLIKADPHEAQTYRENAKRYLARLEETSHYVDRKIASIPRGRRQLITSHDAYGYLAQAHGMHIAGFVTANPGVEPSMAQRRKLNQTIADLKVPAVFLEPNVLRGSSVLAAIAAENSVTVCPIYSDTFDDHVTNYIDLMRFDADSLAKCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY8</accession>
    <name>W4TMY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminodeoxychorismate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70340">
        <property type="protein sequence ID" value="GAE70340"/>
        <property type="gene ID" value="JCM18909_3654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5629" checksum="B0EC5486D6C90650" modified="2014-03-19" version="1">MKRDEVLRAQGAWLLSSVRGVAPILSIDGHPAPQDEDMTHRLRTWAGFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ2</accession>
    <name>W4TMZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69564">
        <property type="protein sequence ID" value="GAE69564"/>
        <property type="gene ID" value="JCM18909_2797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="19"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="497" mass="53234" checksum="D3E8939E15554BF0" modified="2014-03-19" version="1">MKTIRQWVGGEYYEGSPLGVIPVENSATGEVTAELLQASKEDLDHTVEVARDAQKEWANYSLSKRVAIMFKMRQLVLDHQDEMARLIVEEHGKNYSDAIGEIQRGRETLDFATAINVALKGEYSHDVSTGVDIHTTRQPVGVVTGICPFNFPAMVPMWMHPLAVATGNAFILKPASPTPSASLLTAELYKEAGLPDGVFNVLSGDRRSVQDILVHPGIDAISFVGSTPVAHIVQDTGVSHGKRVQALGGANNHAIVMPDSDLDFAAQHISASAFGAAGERCMALPVVVAVGGCGPQVAEKVKKHAEVIKVGEGMGEGVEMGPVISAKAKDRIVGLIDDAEKRGSKVVLDGRGLTVPGYENGHFLGPTVLDDVPLDAPVYTEEVFGPLLAIVHADTYEEALKIVNAQPFGNGSAIFTNDGGVARRFTLDVEAGMVGVNVPIPTPVAFYSFGGWKESLLGDTHIHGPEGVTFYTRAKAITERWPTEKTYAATMSFQREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN04</accession>
    <name>W4TN04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UbiC transcription regulator-associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69579">
        <property type="protein sequence ID" value="GAE69579"/>
        <property type="gene ID" value="JCM18909_2812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="10039" checksum="BE7D51A08AC8CA05" modified="2014-03-19" version="1">MDLAPSAEELRTTGFYDYLRSRDVVVAVGHQRFSARLALPDEARLLNEPPGAALLTMQRTACDESNRVIEFGQHVYRASIYAYENTVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN13</accession>
    <name>W4TN13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70116">
        <property type="protein sequence ID" value="GAE70116"/>
        <property type="gene ID" value="JCM18909_3407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16297" checksum="E87D21EC864A8A2E" modified="2014-03-19" version="1">MSNFKTEHLDAIEGAAPSVDQIEMHPSFNQATFRAELAERGINPEAWSPLGQSKDLDNPVLTDISKATGKTPAQVVIRWHLQIGNIVFPKSVTPSRIVENFDVFDFELSDEQIAAIDGLDHATGSVVTRPLPTSDIDCLIWTSPRKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN26</accession>
    <name>W4TN26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70131">
        <property type="protein sequence ID" value="GAE70131"/>
        <property type="gene ID" value="JCM18909_3427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024551">
        <property type="entry name" value="AspAT_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12897">
        <property type="entry name" value="Asp_aminotransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12639" checksum="41D6F8C2AE432C63" modified="2014-03-19" version="1">MLASLAETMPEGTTWSHPSGGFFVWLTMPGAIDSAAMLPRAVTKLVAYTPGTAFYADGRGQRNIRLSFCYPTPERIKVGVERLAGVMREELDIAETFGLADERRHSRDLGPGPNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN54</accession>
    <name>W4TN54_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69843">
        <property type="protein sequence ID" value="GAE69843"/>
        <property type="gene ID" value="JCM18909_3100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850846" evidence="1">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22746" checksum="3E37B1380F258846" modified="2014-03-19" version="1">MEASMINRPLAALSAMFIALTTGITLSQPAQASPTPPPDPALKQTVSDNEKVAKGPAEIKRGHVDIGPRIVDGKFSLMARDDSANPPVWRNTDDTVLRVADASRIDVPNDDTYSFLGDMRGEKAYVIPQTQDQKSRLAGLEHPSPRDRQKISRVEPISSSQDMKARDKLTCSLKTVSTPPCRCITPPSLASSWFIWSQYARSCQLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN64</accession>
    <name>W4TN64_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69853">
        <property type="protein sequence ID" value="GAE69853"/>
        <property type="gene ID" value="JCM18909_3112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="536" mass="58137" checksum="854812EB93899F52" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN82</accession>
    <name>W4TN82_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">JCM18909_2919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69674">
        <property type="protein sequence ID" value="GAE69674"/>
        <property type="gene ID" value="JCM18909_2919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="131" mass="13757" checksum="07B3CD1E843692D9" modified="2014-03-19" version="1">MAKLSNEELLDAFKEMTLIELSEFVKQFEETFDVSAAAPVAVAAAAGAPAAGGEAAPAEEEKDEFDVILESAGDKKIQVIKEVRGLTSLGLKEAKDLVEGAPKPVLEKAKKEDAEKAKEALEAAGATVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN90</accession>
    <name>W4TN90_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stomatin/prohibitin-family membrane protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69878">
        <property type="protein sequence ID" value="GAE69878"/>
        <property type="gene ID" value="JCM18909_3143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="3">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="388" mass="42381" checksum="92ACCEEE07ADF6C9" modified="2014-03-19" version="1">MSQSIISLVIIVLLVVVLASSIKIIHQQKIGLVERLGKFNRRLNPGPHLLIPIIDRVQYNLDMREQVVPFPPQGVITEDNLMVNIDSVIYFQIVDPERAAYEAQSYKTAIEQLTMTTLRNIIGGMDMEAALTSREEINQKLRSVLDEATGKWGIKVNRVELRAIEPPPTIRDAMEKGARAERDKRAAILLAEGQRQSQILSAGGDRESAILRAQGDREAAVLRAQADRQAQMLRAEGEAQAITTVFNAIHAGQPDQGLLAYQYMQMLPTLARGDSNKVWVVPSELNDALKGLGSLTGKDGHEPSSGGFTVADPARFAAPEKVDVFAEIEAQKVQEKEASEATVQQAIQEAAKLENPGLSGKRSRDDGQVTQAPAEQQAISEQGSGPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN95</accession>
    <name>W4TN95_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAS-II enoyl-ACP reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NADH-dependent 2-trans-enoyl-ACP reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_3148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:18179"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:10242"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mycolic acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69883">
        <property type="protein sequence ID" value="GAE69883"/>
        <property type="gene ID" value="JCM18909_3148"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00915"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21313" checksum="21295613CD4AB385" modified="2014-03-19" version="1">MPEVLELDVTDTDQLAALPQQLRDLGVEKLDGVVHAIAFANPKTALGGKFLETEWDDVSVAVHTSTYSYVSLIAALDSMLAEHAAVVGLTFDATVSWPFYDWMGVAKAGLESANRYLARYLGPKGVRCNLVSAGPLDTMAKTAIPGADAFNDLWGERAPLGWDTKDTTPAAKGIVALLSDWFPATTGEMIHVDGGMGSTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNC6</accession>
    <name>W4TNC6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2968</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69719">
        <property type="protein sequence ID" value="GAE69719"/>
        <property type="gene ID" value="JCM18909_2968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon_1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19325" checksum="0CE69F7CF9340D37" modified="2014-03-19" version="1">MASEVTSDPDADLTQGDSTLRRVTHRSIADITELLEGGRYNVVVARIMELVNATRKAIDSGCGPADPAVREAVTFTAQALSLVAPYLAEEMWEMLGLVPSVANSHWPTADEKLLVADKVTMVVQVTGKVRAKLTVSPDITEAEAREVALADVNVQRFTEGKEIVKIIAKLPKMISIVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF8</accession>
    <name>W4TNF8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="3">1.8.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70276">
        <property type="protein sequence ID" value="GAE70276"/>
        <property type="gene ID" value="JCM18909_3583"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15029" checksum="AF293FD8C5CA47EE" modified="2014-03-19" version="1">MGGLTPNPTYREVCTGCTGHAETVRVTYDPTQVSTEAILTVFLENHDPTQGMRQGNDVGTQYRSAIWCTTTEQFMTATTVKGSYQANLLNAGYGAITTAISMTNGVEFYLAEAEHQQYLEDNPFGYCPVHATGVCLAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG2</accession>
    <name>W4TNG2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70281">
        <property type="protein sequence ID" value="GAE70281"/>
        <property type="gene ID" value="JCM18909_3588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6399" checksum="A8F07127D531F357" modified="2014-03-19" version="1">MVAHPIAELVTPDWAEALTGVEPRIHEMGDFLRAETAAGRGFFTPWRPYSACFLPPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG4</accession>
    <name>W4TNG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cold shock protein CspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69754">
        <property type="protein sequence ID" value="GAE69754"/>
        <property type="gene ID" value="JCM18909_3005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="1">
        <location>
            <begin position="29"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16650" checksum="FAAF10637766C23A" modified="2014-03-19" version="1">MVSGGPSSRLVAWYGGPSTVMTRRSEPEMPTGKVRFYDATKGFGFLTKDGGGDVYVNASALPAGVNTLKPGQKVDFGIVEGRRGEQALSLQIVETPASLSKASRKKPRDMAVICEDLIKMLDKMGNGYRHGRHPDPRTAGAVAKMLRAVADELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI3</accession>
    <name>W4TNI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70520">
        <property type="protein sequence ID" value="GAE70520"/>
        <property type="gene ID" value="JCM18909_3853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="4821" checksum="2D3343031D35B683" modified="2014-03-19" version="1">MTEAVSFGDSVFSKVVSEFADHTNEDPLFSTMVNMLTYPSLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM6</accession>
    <name>W4TNM6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70565">
        <property type="protein sequence ID" value="GAE70565"/>
        <property type="gene ID" value="JCM18909_3910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="276" mass="30056" checksum="194EB9C1EC8878C5" modified="2014-03-19" version="1">MGLLDGQYTAMTSGRSLDFDDLRSYVRGDDVKDIDWKSSARAGELLVKRYRAERRHTLAFVVPAGGPLASAATLTQSKADVVLAAIGVLAWVACRHGDYVTVVAPGPNGPSVARPSYRDTQIEHMLAGLDAGCRLEAPEPDLPELLDLAATGLRRRGIVVVVLDDWDPHPDDVDALARLCARHEVLAIEVSDLDVTDPALAAVPARDQASGRAVPGFVPGDRRVRQQFTAARQERARRRSHTLDRLGVIHESVADVDDSVAAIVRLLERMRHASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP3</accession>
    <name>W4TNP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70351">
        <property type="protein sequence ID" value="GAE70351"/>
        <property type="gene ID" value="JCM18909_3665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="262" mass="28512" checksum="58269A4892A13A48" modified="2014-03-19" version="1">MTRFLHTSDWQLGMTRHYLSKRGDDDPQARFTADRIETVRRLGDVARQEGCEFVVVAGDVFETHNVSTQIIARACEAMASIDLPVYLLPGNHDSLEPGCLWDGPEFARRCPSNVQVLRDHAESQITDGNGVVIATIVASPLTTRHPSTDPLADLVKNLEPAQTPRILVGHGQLEGLSGDAREALISRAPLDDAIARGALSYVALGDRHIAWPTNDNHAAIRYSGTQETTSFNEESVGTAVIVDLGDPLTCQTVNVGTWLHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNQ7</accession>
    <name>W4TNQ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inosine-5'-monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70172">
        <property type="protein sequence ID" value="GAE70172"/>
        <property type="gene ID" value="JCM18909_3469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10477" checksum="00F3EFE3FFF2834B" modified="2014-03-19" version="1">MASARAVRHRTRERSAFERARAALFEEGISQSKMYLDPQRPGVEDLVDFITSGVRSSCTYAGAANLTEFHEKAVIGVQSPSGYEEGRPLQRSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU9</accession>
    <name>W4TNU9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70078">
        <property type="protein sequence ID" value="GAE70078"/>
        <property type="gene ID" value="JCM18909_3363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9941" checksum="DA143966B1440D53" modified="2014-03-19" version="1">MGLCGSDIRNLTTDSRKGDYPFIYGHYGATSVQVQKAFELVIDDKFPAEQVISKVLPLSRINDAIELTRTGEALKVVLVPDGKESEYHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP17</accession>
    <name>W4TP17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69929">
        <property type="protein sequence ID" value="GAE69929"/>
        <property type="gene ID" value="JCM18909_3197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="11884" checksum="01F64769EBF8F0B3" modified="2014-03-19" version="1">MNFDPDIVRREISMMYPYDPEYPWPGYSPEVMDGSLSWRMPDDLVVMEWLFDVITISRWTATRAHSYRSIDRRDSPYRRAMNFSVVSRVRSWGLAPKSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP75</accession>
    <name>W4TP75_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70516">
        <property type="protein sequence ID" value="GAE70516"/>
        <property type="gene ID" value="JCM18909_3849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18928" checksum="5D11B774CAA2DCE2" modified="2014-03-19" version="1">MAERKWAVLVGVTTSGSHASTHWFKSFYEACQKRHIMICGVDFEEELKNKIPPISVDCLIRISGPYRRSLDADEIAKIATEIETRCPGRVALSTALRENYQLQNSLLAEAIGVARNTADCIERIQDKPACRDALRKAGIYQPQSLRIVGVTSDGCLQFSDASGAVVEKTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP96</accession>
    <name>W4TP96_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70233">
        <property type="protein sequence ID" value="GAE70233"/>
        <property type="gene ID" value="JCM18909_3531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG_C" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6497" checksum="05B7642635AF0E5F" modified="2014-03-19" version="1">MRRIDGVQVARSYVMVDYDVPAEALDAATALTPGLELLQCRRCPRTAGMPCELWCRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPB7</accession>
    <name>W4TPB7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70044">
        <property type="protein sequence ID" value="GAE70044"/>
        <property type="gene ID" value="JCM18909_3327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7222" checksum="91C14F3CD0E619E7" modified="2014-03-19" version="1">MEIAMFKGSEGRLFEGAWVAYGDSIRQNVQRIQVVKGFRGDFTTTDNSQRVSFRVTKEPGSECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM4</accession>
    <name>W4TPM4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Succinate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70462">
        <property type="protein sequence ID" value="GAE70462"/>
        <property type="gene ID" value="JCM18909_3789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="338" mass="36614" checksum="025BFAFBBBA3C182" modified="2014-03-19" version="1">MMTNDRSLPSDLPTQLLIDGEWVDAEASRTFDVINPATEKPLVAIADASVDQGTDALDAAVRAQHSWADTAPRERAEILRKTFNLVTERKDDFARLMTLEMGKPLAESYGEVTYGSEFLRWFSEEAVRIRGDYGLLPEGNIRQLVTKRPVGPCLFITPWNFPLAMATRKVAPALAAGCTVVIRPASATPLTTLLLAKTFLEAGLPAGVLNVITGLDHAVTDAILEDPRLRKLSFTGSTGVGANLLSKAAKHVLRTSMELGGNAPFIVFDDADLDQAIAGAKGAKMRNMGEACIAANRFIVHESVAEEFTDKMIEMMSGLVVGDGLDEKIRGRAHDHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPQ9</accession>
    <name>W4TPQ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70507">
        <property type="protein sequence ID" value="GAE70507"/>
        <property type="gene ID" value="JCM18909_3835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="19977" checksum="22EE3BC69BFF26DD" modified="2014-03-19" version="1">MCLQVRDFVLANPRSVPGVEAGEEYVMATIHRADNTDDPKRLAHILDALGNLDRKVILPVHPRLRARAEADGMAIARGNLTTINPLAYPDMVNAVTNAAGVITDSGGLQKEAFLLGAICTTVRTETEWVETVENGWNVLDPDAEHLGEYATRPHPEGDPGHPYGDGKAAHNVATVLLKAGERDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ81</accession>
    <name>W4TQ81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">N-acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3702</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70384">
        <property type="protein sequence ID" value="GAE70384"/>
        <property type="gene ID" value="JCM18909_3702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="91"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="302" mass="33066" checksum="1B374ADCC785D146" modified="2014-03-19" version="1">MIHPGTRGDTAVAPLSSRSGHRKKKDPTSVGAWSALFIGPLMLGIAVFYYWPIFENVVASLQQTNAFGGNPQFVGFENYRELFASPDLRSAIGNTLLYTVIVLLGIPLSVAVAAMIELPGLRFKGLYRILYFMPYLAMPMAVAQVWKIVYSGQFGLLNQILRSVGVSDPPYWLVSPGWALFAVALFGLWASIGFNVIILSAGLKSIPRELYEAASIDGASTWRQFRMVTVPLLSPSIFFLTIMTTIGGFQLFDALYAMIGTGNSAEPRTRSLVSLFYRQASSTMTRGSVLPWRSLSLPSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ97</accession>
    <name>W4TQ97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000086">
        <property type="protein sequence ID" value="GAE70717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70717">
        <property type="protein sequence ID" value="GAE70717"/>
        <property type="gene ID" value="JCM18909_4103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5820" checksum="5E76E8CFC41A1E9B" modified="2014-03-19" version="1">MYRLDGASSVGLGLLTHGWCGVVGLPELSVEAARQWGVELSRLVLVPDPGTGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQG8</accession>
    <name>W4TQG8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylmannosamine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70474">
        <property type="protein sequence ID" value="GAE70474"/>
        <property type="gene ID" value="JCM18909_3801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="342" mass="36439" checksum="46485E72CB0D4FD9" modified="2014-03-19" version="1">MREGSPDRNGAVGRPGTMLTLEGARVCGVGLEINAEYLAVCVVDLCGTVLYDRAQPFDVASLPISDVLDEVAGIMRDTLEQLHSARRHVVQVMVSAPGVIKQPAGTVHLASNLGWRDVPLRSQLLQRLDADISLQVENDAKLAAVAEYRRYEDSDVRDLVYLSGDIGVGAGIIAAGQLMRGWSGFSGEVGHLRLDPRNLPCHCGRTGCWEARVGLPEFLAHTGDRLGAQPIDRLLTQIQDRATRGDQQVLNALGDLATSLAEGLSVVIDMLNPRVVVLGGYFSWFTDFLIPPIAADLTARRLDPGAGALLAGAQFGMVSSAHGAALTALDSVFANPLSVPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQJ9</accession>
    <name>W4TQJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70504">
        <property type="protein sequence ID" value="GAE70504"/>
        <property type="gene ID" value="JCM18909_3832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19408" checksum="23992E483C4AD34F" modified="2014-03-19" version="1">MAATPTVGERFPHAPVTVVRNYPWLGNYTVPPKPVPGQLVYVGDLSEERKLSFMIEVTRTVRKQVPQAHLVLAGRVLPRCQETVEHAVAEGFVEHLGLVAPTEVPQVLTSAQVGLVFLKPLPNYVASLPTKLFEYMASRVPFAASDFPAWREMFDGYGAGIFLLILRMPQLPQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQN8</accession>
    <name>W4TQN8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">JCM18909_3885</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70544">
        <property type="protein sequence ID" value="GAE70544"/>
        <property type="gene ID" value="JCM18909_3885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="127"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="260"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE70544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="386" mass="41312" checksum="0F903D95C271231D" modified="2014-03-19" version="1">MEIRLERDVMAEAVAWAARSLPNRPTVPILAGLLVRAEGDSVVMSASDNETSAQITLSAQVDEPGESLVSGKLLADIARSLPNKPVQITTDPAKMDLVCGSARFTLQALPVDEYPDLPQMPAATGTVDASVFSRAVAQVVVAAGRDELLPVFTGVRVEINRETLSLLATDRYRMALKEITWNPSATDAEATALVPAKVINETARSMTSGEHVTMNLSSGDSGEGLVGFEGDGANGVRRMTTRLLSGEFPKVRHLMDIKATRSVRARTDELINSVRRVSLVAERNTPLRMVINDDSVALSAATGDQAQASEAIEAVVTNHVDGKPTITAAGFNPHYLSDALGALDTPYVHFSFTAPGKPCLVTGLNDLDGRPETDYRHVIMLMRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQW0</accession>
    <name>W4TQW0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70629">
        <property type="protein sequence ID" value="GAE70629"/>
        <property type="gene ID" value="JCM18909_3987"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="236" mass="25001" checksum="DDE5CA1C91B052FE" modified="2014-03-19" version="1">MIKIVTIIALILVGGYLAITGFQPPRSGVPAASFSHLWDRGGFFPTGFMGFIAGFQIAIFSFQGIEMAGTAAAETADPEHNLPKAINSIPARVLIFYVLALGVIMAVQPRDLINPQASPFVEMFSFIGILIAFHIVNFVVLTSAASSANSGVFSTSRILYGLAREKDAPPVFAKLSSRHIPRNALILTAMCIAPAIVLVTLEDSVMDAFFPRCRGLLGALSVGVGTHSGLLPQVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEK3</accession>
    <name>W4TEK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67221">
        <property type="protein sequence ID" value="GAE67221"/>
        <property type="gene ID" value="JCM18909_266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65m" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="5289" checksum="B21437A4D5FC9ACB" modified="2014-03-19" version="1">MLTYTHPRIAENALRFRVNTLPQARRRAKELSERGALFSVANNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEU8</accession>
    <name>W4TEU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydroorotate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_87</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67052">
        <property type="protein sequence ID" value="GAE67052"/>
        <property type="gene ID" value="JCM18909_87"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="2">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="19993" checksum="C0126C5C88CF0D4F" modified="2014-03-19" version="1">MTRLAVSLPGLNLKNPIMPASGCFGFGAEYAEYYDLSVLGSIMVKATTLEPRRGNPVIRVAETPGGMLNAIGLQNPGLDVVMAEKLPWLAEHFPDLPIIANVAGYTTEDYVKVCEAISTSPNVAALEINISCPNVKRGGITFGTNATAAHDLTQAVVAALVCLSTSSCRPMSPTLPRSRVRPLMPVPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEY4</accession>
    <name>W4TEY4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Activator of (R)-2-hydroxyglutaryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67351">
        <property type="protein sequence ID" value="GAE67351"/>
        <property type="gene ID" value="JCM18909_400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="2"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="315"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="4">
        <location>
            <begin position="674"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="878" mass="95307" checksum="9B0BCE6D779DE031" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF12</accession>
    <name>W4TF12_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA recombination protein RmuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67376">
        <property type="protein sequence ID" value="GAE67376"/>
        <property type="gene ID" value="JCM18909_432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6691" checksum="45EB8445C72756D2" modified="2014-03-19" version="1">MRAYNSALGSLETRVLVQARRFEHLGVTADDITSPAPIEEAVRPLTSPELTENQTEEGPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF30</accession>
    <name>W4TF30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67391">
        <property type="protein sequence ID" value="GAE67391"/>
        <property type="gene ID" value="JCM18909_448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="26513" checksum="3F5EEF4F8EE69D77" modified="2014-03-19" version="1">MWAVLAASVLLWLTHALVLAGVRTAAFVNTIATIAKIVPLITFIAICAVAFDVGVFTEDFWGSHAGLGSVFAQTKSMMLVTVWVFIGIEGASIYSKRARKRSDVGKATVGGFLFVLVLLIGVNLLSMGIMHRAKLAGLPDASMGDVLSSVVGPWGSVLVSAGVIISLLGALLAWILLCGETMQVPGEDGTMPKLFGRINKHEAPAPALWITNIVSQICLVMTVLWDGAYLAMATLAAASSWCRTCCQPHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF66</accession>
    <name>W4TF66_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67172">
        <property type="protein sequence ID" value="GAE67172"/>
        <property type="gene ID" value="JCM18909_214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="3">
        <location>
            <begin position="29"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="197" mass="21364" checksum="BAE0892B4F5AB570" modified="2014-03-19" version="1">MPIIVKALQKDGPDQPFKVVEIERRDPRPDDVVIDIKAAGICHSDIHTIRNEWGQAHFPLTVGHEIAGVVEAVGSGVTKYKPGDRVGVGCLVNSCGHCEQCEAGEEQACLNGPVGTYNSRDVDGTITQGGYSQKVVVNEGVCLPHPRFPGLRGGSSAAVRRHHHLFADRPVERRTWPESSRAGARRTGPYGSPDCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFD4</accession>
    <name>W4TFD4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane alanine and valine and leucine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67143">
        <property type="protein sequence ID" value="GAE67143"/>
        <property type="gene ID" value="JCM18909_183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6869" checksum="2C16ADDA4216E652" modified="2014-03-19" version="1">MLGSILARDGFLPRRLHARGDRLAYSNGILTLATGAIILVLVFNASVTALIQLYVVGVFLSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFF6</accession>
    <name>W4TFF6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67700">
        <property type="protein sequence ID" value="GAE67700"/>
        <property type="gene ID" value="JCM18909_778"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4083" checksum="B1423F17551839F4" modified="2014-03-19" version="1">MGEVILDTNKSPGQLRIVTASSFKIAKCHRGLSRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFF7</accession>
    <name>W4TFF7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67262">
        <property type="protein sequence ID" value="GAE67262"/>
        <property type="gene ID" value="JCM18909_308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="243" mass="27013" checksum="A37FD9CC6189F286" modified="2014-03-19" version="1">MVRLVSFFTDGNQIGAVLDRNGLRPARYWVTDDGLVVFASESGVLDLPDAHVVEKGRLKPGQMFLVDLTEHRVVDDLEIKARLASAKPYEEWLDQGRIDLDDLPERTHIIHSHASVTRRQQLFGYTSEELKMLVAPMANQGVEATGAMGTDTPLAVLSNRPRMLWDYFSQLFAQVTNPPLDAIREELVTSLTGTIGPEVNLLEPGPESCRQVVVNYPIIDSTSLPRSFTSTLTGSIRIAKPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFQ8</accession>
    <name>W4TFQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67362">
        <property type="protein sequence ID" value="GAE67362"/>
        <property type="gene ID" value="JCM18909_412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_2c" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12309" checksum="DE58EFA7AD4E1607" modified="2014-03-19" version="1">MLRRLLRRVVRAMRLLGVVDPVLPELLSVSRDLMADSFPDVLTQWDRVIGAATAEEDTFRRTLSSGTAMLDAAVVETKASGSKTLSGEKAFQLHDTYGSQSTSLSKWRPSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFR0</accession>
    <name>W4TFR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67810">
        <property type="protein sequence ID" value="GAE67810"/>
        <property type="gene ID" value="JCM18909_895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15686" checksum="54028B6B0DCDF8DF" modified="2014-03-19" version="1">MRHLLESRVVEEYACADSTGGRRPTKLRVAPAVGNAFVAELGQHHARLAIASREGELLATDDIKINIEIGPEKTIKALAKGGTSLVTRSLERWFQPVWRYPARWTVVVTSLGQRGCWVEWQRHRRHVDTGTRGAISYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW5</accession>
    <name>W4TFW5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mobile element protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67328">
        <property type="protein sequence ID" value="GAE67328"/>
        <property type="gene ID" value="JCM18909_375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16641" checksum="362A5090FB79BEB2" modified="2014-03-19" version="1">MNAMGLKGFTKRHRCITTNRKPGHRVMPDLVGRGFTAPGPNKVYVGDITYLPRKGGKNMYLATVIDVYSRKLVGHALTDHMRTSLVIDALDHARSVRRSLDDAIFHSDHGSVYTSQAFQDFCQSLGVSQSMGAVGTSADNALAESFNATLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW6</accession>
    <name>W4TFW6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67676">
        <property type="protein sequence ID" value="GAE67676"/>
        <property type="gene ID" value="JCM18909_753"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045931">
        <property type="entry name" value="DUF6350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19877">
        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="287" mass="29245" checksum="3D618EAD700E341B" modified="2014-03-19" version="1">MMAAGATTTHWLAAMVGALLIGLCSGTVGACRGAHINPLSRLPHWARGLPKAVGATVAVCLAGGSAALAVALLVHADRVIHLHQQIGATGWGGFCLILLQLAWLPTMALWGTAWTMSPGFAFGTGTFVSPLGTHLGIVPALPVLGALPSNGPLNPAACAWFAVPVVAAIVGGILVMRSLPEAGFEIGCGLGALSGLLSGLVLGALGSLSSGSLGDGRLSEVGTIMPATGGCAVGVLTLVTMLCGFVIGLSRRLRSEESRQGRVERRQERKKRTTPSKPRKKSSQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX0</accession>
    <name>W4TFX0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GTP cyclohydrolase-2</fullName>
            <ecNumber evidence="13">3.5.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GTP cyclohydrolase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribA</name>
        <name evidence="16" type="ORF">JCM18909_759</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="13"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67681">
        <property type="protein sequence ID" value="GAE67681"/>
        <property type="gene ID" value="JCM18909_759"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="15">
        <location>
            <begin position="216"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="261"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GAE67681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="438" mass="46555" checksum="89358FE35F9C7763" modified="2014-03-19" version="1">MLNTIEEVLAELRAGRPVLVTDDADRENEGDAILAAELADPRWVGWMVRHTSGYLCAPMTEERADQLDLPLMWPASQDPLRTRYTVAVDAAHGITTGIDAVQRARTARVLADPSSTPSDLVRPGHVLPLRARAGGVLERRGHTEAAVDLARLAGLEPVGLIGELVGDDGMCLRADAIADLARTEGLALTTIDQLAQWRQAHDPGPAVPTQRVTALASAHLPTRHGQFAITGYRDNCTGAEHVLLVGEKGIDADDGGPAWVRVHSECLTGDALGSLRCDCGDQLAAAQQHVCCHGGAIILLRDHEGRATGLLNKIAAYKAQDGGLDTVDAQTHLGLPVDAREYGAAVAILANVGITSVRLLTNNPAKAEALRDGGLEVTMSPIETSARPEDERYLRTKRDRMGHVLALDVSPSEMSTQPLASSHATSTTPALTIKGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG11</accession>
    <name>W4TG11_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67726">
        <property type="protein sequence ID" value="GAE67726"/>
        <property type="gene ID" value="JCM18909_806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6348" checksum="DAB27B5A82200605" modified="2014-03-19" version="1">MDHRLRNVDRVERNAVSDATSAATAAQPIPGRWKALAVLAAGSPSSSWTAQSSVLPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG23</accession>
    <name>W4TG23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67383">
        <property type="protein sequence ID" value="GAE67383"/>
        <property type="gene ID" value="JCM18909_439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="3"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="391" mass="40740" checksum="5124878C1D6096D7" modified="2014-03-19" version="1">MLLLAIIYLAFISLGLPDSLVGAGWPAMHESLGVPLSCAGFITFIIATGTIISSLMSDRLTTRFDPGRVTAASVALTAAALFGFSFSTQFWVLCLWAMPYGLGAGTVDAALNNYAALHYTARHMNWLHGCWGLGASISPFIMSQALSSGHGWPSAYRTVGTLQAILTAIVTVSLPLWNKTRKINGGGSARLFDHVPTRAALATPGVPAVLGAFFSYCAVESTSMLWAASYLVSVRGTDGATSAAFASLFVLGITAGRFLAGFVAERISDRMLVRGGFITVGVGVILVGLPGVPSWVALAGLVIAGLGSAPIYPAIIHSTPTTFGAHNSQAIIGIQMAAAYVGTTLAPPLFGAISANTGLWTLPLYLVVLVIFGLVMSEQVTRRGRARAQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG24</accession>
    <name>W4TG24_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Permeases of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67467">
        <property type="protein sequence ID" value="GAE67467"/>
        <property type="gene ID" value="JCM18909_529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12806" checksum="76C5A0D586FBDE84" modified="2014-03-19" version="1">MWVLSFFSVPLFMVMGTGQLWKACLAEGVLCLFLTANDGTMASYLAESFPTELRYTGFAVSQNLANAVFGGTASAVCTWVIGVTGSRLAPAWYLTAVSLLSLCAMVASHEHTGRDLSEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG34</accession>
    <name>W4TG34_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoglycoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67482">
        <property type="protein sequence ID" value="GAE67482"/>
        <property type="gene ID" value="JCM18909_544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11310" checksum="2711ECE3E4B41930" modified="2014-03-19" version="1">MGDHLHCRPYCRLHGTDACTGLTPYQRRRSPHRNVKGHHRRGPIGQSGRWYTDGQGRAILTAGVNMVSKRHPYSPEADGFDDADAAWLQKNGFDSVRLGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG70</accession>
    <name>W4TG70_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67527">
        <property type="protein sequence ID" value="GAE67527"/>
        <property type="gene ID" value="JCM18909_592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21451" checksum="EB596513F915D2A6" modified="2014-03-19" version="1">MTGFFPIMMFALPGAALAVYHTAKPERKKLTGGVMISVALTAFLTGITEPLEYAFAYVAFPLYLVHALLTGSSLALCNALGIKDGFGFSAGLTDYIINFGRASELSGGPGKVLLLILIGLVYAVIYYAVFRFAITKWNLRTPGREDEGDDTTGGASVFDEAQLAASESTGKADAQKKRDESDPFESPTLMMAPWLNTEGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG89</accession>
    <name>W4TG89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67547">
        <property type="protein sequence ID" value="GAE67547"/>
        <property type="gene ID" value="JCM18909_614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13376" checksum="FE72F465BE6706E7" modified="2014-03-19" version="1">MPTASWEYWTHYMVTPNRLGGLTWAGNQSLSGLLLRLGHGNHTLVWLVLVALCCVLAGVASRRLWQGGGTDQVWSLLCAGLCGCLVSPVSWSHHWVWGSLIIVAGLADRRRCRQVLALIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC0</accession>
    <name>W4TGC0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67199">
        <property type="protein sequence ID" value="GAE67199"/>
        <property type="gene ID" value="JCM18909_242"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="10"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="241" mass="25237" checksum="153CFEEAFA3B5AC7" modified="2014-03-19" version="1">MLTKGCKKMLGLMGAMEDEVRLIRADLDDVEELDGPCELLRGRLDDTPVVLAQCGIGKVNAALAASAMVQAGATRIVFTGVAGAVAPGLGIGDVVVGNRFQQHDADDTAFGNPIGTVPGEPPYWEPDPDLFALVLDVLRALEEPRDHQVVAGPIVSGDQFIAQAEKVAWLRATFGASAVEMEGAALAQAANRLGVPFAVVRILSDSADGDAVADFPAFLNNAAHRGRDLAHALARQHGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD1</accession>
    <name>W4TGD1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67468">
        <property type="protein sequence ID" value="GAE67468"/>
        <property type="gene ID" value="JCM18909_530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16880" checksum="86D22059473871B8" modified="2014-03-19" version="1">MYYFNDHEELLAEAAKLNIRAWAHIAETIADEAENHRPKTGVDDVIEYLIRAMITRPAPLLGHYLELISAGDNETISNAYHAGRGRLNNAISRILAVANLPYPAELVIAVIDGGIVTALSEGRDPHATVEDLLRQLISLPTYKAPMSQAPPTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH7</accession>
    <name>W4TGH7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67637">
        <property type="protein sequence ID" value="GAE67637"/>
        <property type="gene ID" value="JCM18909_710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22274" checksum="686A4005CA6960CA" modified="2014-03-19" version="1">MTSDLFRDSGRSDRTPDASMFSDFKVSVTFPGKVLSHSGSSKVDGNTVTWTDPNDLFSSSGLTATSKRSNGIPTWVWIVVAVAVLVIVGVVVVILNKKKGQKAGQPENGGAPWTMQYPGDGQPQGQPQQWNGQPYQGDSYAQPPYQDPNYQDPRQQEPGQLWGNQPLGHVSDGTTSAPQTGQNQGSQPGQQPPSDPDDFWKNHGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK4</accession>
    <name>W4TGK4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67284">
        <property type="protein sequence ID" value="GAE67284"/>
        <property type="gene ID" value="JCM18909_330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850740" evidence="1">
        <location>
            <begin position="36"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="336" mass="37391" checksum="E815315134378193" modified="2014-03-19" version="1">MTMNTDRLITRRTVMSATCVATVAAMMSPAPTAEAKADLGRPRVMWQQCVERALQCFPTGGGYHTGRNIPPGFRQTAWTGLDRAVRVTATGVCVDPHLATPSFCSSATYLLLLKSFELYEKTCGVMPPRQEWEYLKPYTVDNRPYPIQNDGVGAWGRANANGPGLAELAHELKIGTNLYIGTTGEYANPGDRNAMFASIRRYDFMKIFWNDEIGKDERGHMVVVLGRSSHSNCSRNRVETVRYWSSNGSHTDINGGYGIKCVSEDKIHRAVVTRVDRPWNVWNTEVMGPTDVCAPLAEIAADRNMAPDELKQLVEAKSCWPRRFSGSHGAHGRYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL3</accession>
    <name>W4TGL3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68105">
        <property type="protein sequence ID" value="GAE68105"/>
        <property type="gene ID" value="JCM18909_1219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="1">
        <location>
            <begin position="193"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="356" mass="38182" checksum="530F51878DAC644A" modified="2014-03-19" version="1">MNVAEQLVQQLLDAGVRRIYGIVGDSLNPVVDAVRKTGGSVKGGIDWVHVRHEEAAAFAAAAEATLTGELAVCAGSCGPGNLHLINGLFDAYRSQIPVLAIASHIPSVQIGMSYFQETHPDRLFVECSDYCELVSTPEQAPRVVNSAIRHAVAGSTVSVITLPGDISDKKAAAPSPVFIPSRRPTIEPNPEDVRQLVKLLNDVRKVAIFAGAGVEGAHDEVLALADKLKAPIGHSLRGKDFIQYDNPFDVGMTGLLGYGAAAEGMNDADVLILLGTDFPYNQFLPDTLTVQVENRPEKLGRRTDVSFPIHADVKALCDAVTPLLKQHDDKFLKAAVKRHAKIMKPRSARTLAMSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN6</accession>
    <name>W4TGN6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67697">
        <property type="protein sequence ID" value="GAE67697"/>
        <property type="gene ID" value="JCM18909_775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5420" checksum="90F7BF016E0D397C" modified="2014-03-19" version="1">MVFAASVLMAGILRVVLPEQSAGLLAVRTRWIDSVLLLGLGAVMVVVILTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGV5</accession>
    <name>W4TGV5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding and nucleic acid-binding protein YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67379">
        <property type="protein sequence ID" value="GAE67379"/>
        <property type="gene ID" value="JCM18909_435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="3"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="193" mass="20876" checksum="16F5C0C90599C08A" modified="2014-03-19" version="1">MALTIGIVGLPNAGKSTLFNALTKNDALAANYPFATIEPNVGVVGVPDKRLDVLTEMFHSAKTIPAAVSFVDIAGIVKGASKGEGMGNEFLSNIREADAICQVTRCFADDDVTHVNGHVDPSDDIETITTELVLADLQTMEKQLPKLQKKKPRSRRSLVPKPRRGSRLRRCSKRARRSSQPGSIPSRCMTSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW3</accession>
    <name>W4TGW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68006">
        <property type="protein sequence ID" value="GAE68006"/>
        <property type="gene ID" value="JCM18909_1112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="216" mass="23287" checksum="1F22682BF877A810" modified="2014-03-19" version="1">MDQPNYVTDQDTMSTTPKQPRTATAARRRHIVDHLRSLGHSESIGDLSRLFGVSTSTIRRDVDALSDESKIWKISGGDVMIRRHEPTWHEKEQCEHVSKAAMATYAAEHLVNEGDLVLLDSGTSTAALGRLLSTRDDTTILVGGLSVLQAVAEGTANVMVLGGALRQHSGSLLGPWATSNLRSITLMSRSSAATQSLRPTGSTAHSWSPSSSNTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGZ9</accession>
    <name>W4TGZ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c-type biogenesis protein CcdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68051">
        <property type="protein sequence ID" value="GAE68051"/>
        <property type="gene ID" value="JCM18909_1159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="4735" checksum="BF70FDDE3FECA8A6" modified="2014-03-19" version="1">MTPLDLGSWAAGALTGSMAGAIPVAVFAGLLSFFSPCVLPLIPAISAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH67</accession>
    <name>W4TH67_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulphide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68310">
        <property type="protein sequence ID" value="GAE68310"/>
        <property type="gene ID" value="JCM18909_1438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="2">
        <location>
            <begin position="2"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="61"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="318" mass="34776" checksum="0BE09AA7E041DA05" modified="2014-03-19" version="1">MTADNPFPAIHGRVCYHPCEVACNRADLDGAVSIHSVERYLGDLAIEKGWTFTRPTEPSGHRVLVIGAGPAGLSAAYHLAMLGHDVEIHDAGDKVGGMMRYGIPEYRLPREILDAEVARLTDLGIKIVLNHPVNDLMEEKAKGRFDAVFVAIGAHLSKRVDIPTVDASRMVDAVSFFLHNVASGEKPLIGRRVAVYGGGNTAMDAARVAKRLGAEESIVVYRRTAEQMPAHAEEREEAEREGVQMNWLRTITDVGDDLTVEVMELDEDGKPHGTGRYEKLEADTVILAVGQDADTSFLHKMPGMRFRNDVVDVNPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC3</accession>
    <name>W4THC3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68360">
        <property type="protein sequence ID" value="GAE68360"/>
        <property type="gene ID" value="JCM18909_1489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="19035" checksum="38C4655281627B61" modified="2014-03-19" version="1">MSAESWLSGRYELQNLIGRGGMADVWKARDHRLGRDVAVKKLRTDLASDDTFQARFQREAQSAARLNHPNIAAVYDTGETKDPATGLPVPFIVMELIDGHTLRDVLRDGRKILPRRALEFTQGVLDALSYSHTAGIVHRDIKPANVMLTREATSRSWTSVSHVRSPTPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC5</accession>
    <name>W4THC5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67549">
        <property type="protein sequence ID" value="GAE67549"/>
        <property type="gene ID" value="JCM18909_616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8647" checksum="9C683863A14DDB94" modified="2014-03-19" version="1">MGAAELRQARKNMDRLDRQMGKVRDELAALHEEMAAKADDYQALVDLQAKANELDERMTNLEEQWLETADIVEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI3</accession>
    <name>W4THI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TsaD/Kae1/Qri7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67624">
        <property type="protein sequence ID" value="GAE67624"/>
        <property type="gene ID" value="JCM18909_697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18352" checksum="1793583BA9F71ACA" modified="2014-03-19" version="1">MLGLPYPGGPVIDKAAAEGDPTAIRFPRGLTARHDMVKHRFDYSFSGLKTAVSRWVETQQRDGVEFRIADVAASFQEAVADVLTAKAVDMCQEYGLTHFLIGGGVAANSRLRTLLAERMADAGVELRRPRPGLCTDNGAMIAALGVQVVKAGLPASAMDISADSGLPIETVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI5</accession>
    <name>W4THI5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TmRNA-binding protein SmpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68405">
        <property type="protein sequence ID" value="GAE68405"/>
        <property type="gene ID" value="JCM18909_1540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8854" checksum="B97751713D671FF5" modified="2014-03-19" version="1">MPREQGVRVVARNRRASHDYTIGDTWEAGLVLQGTEVKSLRAGKATLTDAFAQVDERGEVWMYNLHIPNMPSEHGETTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI8</accession>
    <name>W4THI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron(III) dicitrate transport system permease protein FecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67629">
        <property type="protein sequence ID" value="GAE67629"/>
        <property type="gene ID" value="JCM18909_702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="19771" checksum="AD07A07AB806EB3C" modified="2014-03-19" version="1">MILLGIALVFGFYALLALLQYRATPEALQQIVFWTMGSLQRATWTSNAIIAAVLAIAIPITIRHSGQLTALRLGDERAAAMGVNVPRLRSRILILASLLAAVTVAFAGVIGFVGLVGPHVARILVGEEQRYFAPASAATGAFLLATAHALSITIIPGVAIPIGIITALVGVPVFVSLILTRHRVFGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL6</accession>
    <name>W4THL6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67669">
        <property type="protein sequence ID" value="GAE67669"/>
        <property type="gene ID" value="JCM18909_745"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="15103" checksum="AA8A345FC59AFD83" modified="2014-03-19" version="1">MCTVTVLRQFPEVREQYRRRFRHVLVDEYQDTNTTQYQFIRELCGDDPVELDDGARSVDPPELMVVGDSDQSIYAFRGATIRNIIDFEKDFPGARTILLEQNYRSTQTILTAANNLIKVNLNRPAKKFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV8</accession>
    <name>W4THV8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate-1-semialdehyde aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68008">
        <property type="protein sequence ID" value="GAE68008"/>
        <property type="gene ID" value="JCM18909_1114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14456" checksum="14B2132CCB675643" modified="2014-03-19" version="1">MSGNPLATVAGVKTLQLADAGVYQRLDVRSEKWRNELESALDAAGVTYRLQNAGNLFSVFLGVDSPVRNYDNAKSQNAEAYTAFFHAMLDAGVNLPPSCFEAWFLSDAHDDEAFEVFRAALPKAAQAAAQVISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI30</accession>
    <name>W4TI30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68187">
        <property type="protein sequence ID" value="GAE68187"/>
        <property type="gene ID" value="JCM18909_1308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039648">
        <property type="entry name" value="DHPH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00070">
        <property type="entry name" value="Pyr_redox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox" evidence="1">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5789" checksum="E163037F0D4D5C69" modified="2014-03-19" version="1">MFARFGSQVTLLEAGETFAPALDADIAERVRNMLEGEGVTVVTGAQVTSCDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB1</accession>
    <name>W4TIB1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Galacto-N-biose-/lacto-N-biose I ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1644</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68501">
        <property type="protein sequence ID" value="GAE68501"/>
        <property type="gene ID" value="JCM18909_1644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="50"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="255" mass="28037" checksum="03846D6C6DC8D91F" modified="2014-03-19" version="1">MLPIIWLVIASTKNNTDPVSTSGFAFGEFNWAANWHSLMAWTKGMFPRWVLNSLLYSTVSGVVGTLISVSCGYAISKFRFPGRRVLLVVIMVGLLMPVALLTVPLYLLFIKMHLVNTMWAMIIPSMVSPFGVFLGNVYADSSVPTELLEAARIDGAGELRIFSTMVLRLLAPAMVTIFLFIFVATWNNFLLPLMMITDENLQPVTQGLYGMMAYFAPDKGAVMLASVIGVVPLVILFLVLQRYWQSGLAAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB2</accession>
    <name>W4TIB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68272">
        <property type="protein sequence ID" value="GAE68272"/>
        <property type="gene ID" value="JCM18909_1396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_51K" evidence="5">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13470" checksum="20573C851BC85948" modified="2014-03-19" version="1">MPPDDVVSLVKDANLRGRGGAGFPTGMKWSFVPKDNPNPTYLVVNGDESEPGTCKDMPLMMASPHTLVEGVIIASYAIKAKMAFIYIRGEVLHVVRRVQQAVREAYSAGYIGKKHPRFRVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG5</accession>
    <name>W4TIG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Solute-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68228">
        <property type="protein sequence ID" value="GAE68228"/>
        <property type="gene ID" value="JCM18909_1351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="26542" checksum="D2997EDCC7ED3D64" modified="2014-03-19" version="1">MWRIHRYIQQQYEQRHLGRESFVDLLGGGPPDTRRPSSCGIRKNPNTQVKWIATEANRKIYPKMLTAVKANNAPDLAQVGYEALPSFVIQDAVQDIKEWAGDVDKNFTAAGAKSVNLGGTVYGIPVDTAPMAMIYNKALLDSLRIKVPKTWDEFASAARAVKKADPKASLTYFSSDPNFLAGLVRQAGGRWYDVTDSTVKVIMTQDAASRKVADFWQKNSSTKAAFPSTRATPRRCTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL4</accession>
    <name>W4TIL4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67964">
        <property type="protein sequence ID" value="GAE67964"/>
        <property type="gene ID" value="JCM18909_1066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021517">
        <property type="entry name" value="DUF3180"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11377">
        <property type="entry name" value="DUF3180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13085" checksum="C9165517BA5AC1BF" modified="2014-03-19" version="1">MPILPWSLPVVILVAAIATWGYARAFRTKVVDPQREVEANQGLVSLALGKAIALSGAAFVGACIVYVLTFVWHLNIPYPRQRAIVGGVTAITCAAMAWAGWFLENACKVPKGPDDSEKHPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL5</accession>
    <name>W4TIL5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_1397</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68273">
        <property type="protein sequence ID" value="GAE68273"/>
        <property type="gene ID" value="JCM18909_1397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="11">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE68273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="193" mass="21499" checksum="D744A1E61209F5B1" modified="2014-03-19" version="1">MEGRRGQPRLRPPFPAVAGLYASPTVINNVESISTVPSILRNGKEWFKSMGTEKSDGFTIYSLSGHLAHPGQYEAPMGTTLRQLLDISGGMRQGHELKFFTPGGSSTPILTKDDIDLPLDYEGMAGVKTMLGTKALQCFDETTSVVRVTLRWLEFYKHESCGKCTPCREGTWWVVQMLRRIELVRAKRVTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN4</accession>
    <name>W4TIN4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-isopropylmalate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68392">
        <property type="protein sequence ID" value="GAE68392"/>
        <property type="gene ID" value="JCM18909_1527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7408" checksum="17D0AB9310B00A1E" modified="2014-03-19" version="1">MEEGLDEIGSRFAGIARNNSANNGLLLAQVDPEVVEELWDFAEQHPGEQLTVSLENRTISLPGRLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY8</accession>
    <name>W4TIY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68492">
        <property type="protein sequence ID" value="GAE68492"/>
        <property type="gene ID" value="JCM18909_1634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_C" evidence="1">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="222" mass="23938" checksum="3BC1E76B5510DA90" modified="2014-03-19" version="1">MVCSKAGQLGQFRFCPIRLQQRVPFPEDMSFVVIVSGVAAEKTGAARDLYNAASLATREIIERWNSTTGREDAVLGDALVADPNAEKLHEVVSDRADLTRRLNHFLTESESIIPEASKALACGDLERFGRMADESQRAAEDLLGNQVPQTSALARIARELGATGATSFGAGFGGSVWALVPNAEAPEFASTWLGKYRDEYPEEAGQAVTVVTRPGPSARRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ25</accession>
    <name>W4TJ25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68542">
        <property type="protein sequence ID" value="GAE68542"/>
        <property type="gene ID" value="JCM18909_1688"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="1">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="23712" checksum="4EFB70682EC995F5" modified="2014-03-19" version="1">MSGVNSFGVDWAGRQLAKLAKPGQIILCVTKGMQADEDGTLHILPEVLKKHMGNLADEVHWAAIVGPSIAGELAVHRDTCVVFCGEEQEVLDRLAAAYRTDYYHVWTSTDFIGHEVGACMKKHLCLWWSFAAGMLDKAGQTDAKYVMYDYTAALFGEGARELKQMVASWAVTRRWRPAWAVSAICSLPRWADAMCVPEPMSVPECRSCRSVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ28</accession>
    <name>W4TJ28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68945">
        <property type="protein sequence ID" value="GAE68945"/>
        <property type="gene ID" value="JCM18909_2120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="520" mass="56070" checksum="2E29A82C5705AD5F" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ72</accession>
    <name>W4TJ72_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68448">
        <property type="protein sequence ID" value="GAE68448"/>
        <property type="gene ID" value="JCM18909_1586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29820" checksum="078581EA0C7214DE" modified="2014-03-19" version="1">MPTHRLHREIITTEAVNRFVDSQGITAYYRLHLQTGADIAQVIRCQLAVRSVFGLGRVETDLTHLGLDAVRTAKIRLALTDLAMHATRWFLNHGGADDIAGTIETYRPGVATLVEKLSERLLGDSADAWQEKVDEVTELGLDRSDAAVVAAYDWSPVLLSIVEISEEGHPLDEVADAYLTLARRVDMIRLTRLVEQLPQDRPTDARVRASLREDLLRVMSDATRRALVIGTDNVLADGGRIVKSIAANPDLAHCVVMVSDLRSAVGQDVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ95</accession>
    <name>W4TJ95_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport ATP-binding protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68612">
        <property type="protein sequence ID" value="GAE68612"/>
        <property type="gene ID" value="JCM18909_1759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="12773" checksum="469D48F59B134BED" modified="2014-03-19" version="1">MGVPAGGHVVVTGASGSGKTTLVNLLLRHHDPDVGQVLVDGEPVSSFTLDSLRRCVGVVSQRVELLNASIVDNLRLVAPAAGDGELWRVLGEVGLADEVRGMEAGLRTVVGPAGTRLSGGVRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM4</accession>
    <name>W4TJM4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69155">
        <property type="protein sequence ID" value="GAE69155"/>
        <property type="gene ID" value="JCM18909_2344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="16197" checksum="135F0279386B0427" modified="2014-03-19" version="1">MPFLTVVLAGQLTYSAFEAFKGSLIVPLTETLGIRIDQFGILMGWLGIAMFLYVPGGWINNRFTIRSILCSWCAWRLITGLILFSIPNLSFDVMIVIAASWGVWDAIGWPAVVNGVASCPKMRTRRVEAWQWACWSQFAAVLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJU9</accession>
    <name>W4TJU9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">JCM18909_2249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69066">
        <property type="protein sequence ID" value="GAE69066"/>
        <property type="gene ID" value="JCM18909_2249"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="322" mass="35339" checksum="365C3821DDFF0639" modified="2014-03-19" version="1">MSGTTRPNNKHLMICSGRAYPELAEQIAAELGVELVPSRQVTYANSEIYVQFQESVRGCDAFVIQSHSAPVNEAMMEQLIMIDALKRASAKRITVVSPFYPYARQDKKHLGREPISARLMADLYQAAGADRIMSVDLHAAQIQGFFDGPVDHLWALPVLADYVTSKYDNSDMVVVSPDAGRVRLADMWTDKIGCQLAIIHKRRDPNKANETTTHEVVGEVDGKTCLLVDDMVDTAGTMCQAALALKKHGAKRVIAAATHPILSDPAAERINNSPIEELIVTNTLKIRDDIDIPAMTLLSIAPLIAKAIQEVFEDGSVTSLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV0</accession>
    <name>W4TJV0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68708">
        <property type="protein sequence ID" value="GAE68708"/>
        <property type="gene ID" value="JCM18909_1860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="7">
        <location>
            <begin position="105"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19380" checksum="FA3EAC5E6BF4CED5" modified="2014-03-19" version="1">MSAMGVMSTHSSWHPHVGDDMNGTHHGAGDNPRMTTESSMSDHDVEAIAASLPVRDGDEPWTADEISEIVDTLESDVQRMGTALAKAENDLADLMKQGNDGAGMDTIDVGSSQFERDQEISVTRNARAVYGQSKLALQLLDGGTWGTCESCGEPIGKARLQAFPRATMCVKCKQRQERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ9</accession>
    <name>W4TJZ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68758">
        <property type="protein sequence ID" value="GAE68758"/>
        <property type="gene ID" value="JCM18909_1915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="4699" checksum="BE4FA184305E39C3" modified="2014-03-19" version="1">MSDTAPQTAEVGVIGMAVMGSNLARNMAHKASVSPSITAPHHVPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK37</accession>
    <name>W4TK37_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68892">
        <property type="protein sequence ID" value="GAE68892"/>
        <property type="gene ID" value="JCM18909_2064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12074" checksum="EA995CC4202B27CA" modified="2014-03-19" version="1">MSGDYGTESVHELISSKYFPEDEHTTKRLWVPVDRDSLVAMTAARPAVRALDSNARSNVLTKVAALADDSAGTSGLHLPYQLECWRAWVDHDELTTPIRPHDDGLTITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK53</accession>
    <name>W4TK53_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69181">
        <property type="protein sequence ID" value="GAE69181"/>
        <property type="gene ID" value="JCM18909_2372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="13"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20821" checksum="A79A13DF2FC924D9" modified="2014-03-19" version="1">MRATDYPYCQSPFTVLAHRGGAGMAVNKGIENTLAAFGHAVEVGCTYLETDVHATSDGVLVAFHDPILDRVTESGGVIAAMPWHKVKQAKVGGEPIPTLDEILDAFPEAFINIDIKHDGATMPLIDVLSRHRAWSRVCVGSFSSKRIQTFRRLVQGRTVTAVGPVGVGWAVIGLIACRWHSPMGMRTRCRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK86</accession>
    <name>W4TK86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69216">
        <property type="protein sequence ID" value="GAE69216"/>
        <property type="gene ID" value="JCM18909_2410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="27105" checksum="6F2C4AD43BAFF850" modified="2014-03-19" version="1">MQGHESQTKARANLGTMRFRHMDRPWVVVAFGGWNDAGTAATQAASLIAEYSDAKIWRTIDGEVFHDFRQTRPAITVMNDLEIVSWPSTAIRVGRWQGQPIVVVDGPEPSLRWRTYCFRLLRRLRKLKPAGLVVLGAMATDVAHTRQLPVMVSATDPNLISELGAEKLEYDGPTGIPFVLVTEARRHGMNAIGLWVGVPQYACESLCPPAVQALLVRIEELTGIAIPQAGLEEDKRDWAAAIDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE4</accession>
    <name>W4TKE4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoenolpyruvate-protein phosphotransferase of PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68992">
        <property type="protein sequence ID" value="GAE68992"/>
        <property type="gene ID" value="JCM18909_2171"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="10858" checksum="55E3C29E53842B4E" modified="2014-03-19" version="1">MRTLSGLGVSAGVGQAHALVVSPAPGLPASDPSRGAEADLAKVEAALGKVADRLDERSLHADPSALAVLQATAMMLAIPGCLPASSPTYPTGMVRPTRCGQPSTISALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE5</accession>
    <name>W4TKE5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68629">
        <property type="protein sequence ID" value="GAE68629"/>
        <property type="gene ID" value="JCM18909_1777"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="249" mass="26198" checksum="F65C8159191049C9" modified="2014-03-19" version="1">MNRSARSPLPSSLLTDLLEALGESKVSQDPLDLAAVAPDASHYLLTPSVLVRAGSTSDVAAAMATAKRHKVAVNFRSGGTSLSGQGLTNGVMVDTRRSFRGIEVLDGGRKVRVQPGATIVAVNSVLARYGRKLGPDPASSVACTLGGVLADNSSGMSCGTVANSYRTLDSMVFVLASGTVIDTADPQCEDKLAHDESELIETLMALRDQCREQARADEITFQFSRKNTMGYGSTPSSTTTLQRRSSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH2</accession>
    <name>W4TKH2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68908">
        <property type="protein sequence ID" value="GAE68908"/>
        <property type="gene ID" value="JCM18909_2080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10075" checksum="5A2B2F5527FBC494" modified="2014-03-19" version="1">MLLTFPKNKFATLAISFTSDGPGRMTIQGTDGWIEVEPRFHHPSRILIHRRGVIPEVHNTPALGRGSSDHSPTPRPQEIVRTLVSPKLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ7</accession>
    <name>W4TKJ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69052">
        <property type="protein sequence ID" value="GAE69052"/>
        <property type="gene ID" value="JCM18909_2234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849123" evidence="7">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="13922" checksum="F0424581AF068F00" modified="2014-03-19" version="1">MPAFHVAFILLALPVVIALIAENTGHVKAVAEMTGKNLDHQVGRAVAADGATSMLATFLGAGPTTTYSENIGVMAATRVYSTAAYVVAAVVAILFGFSLSLALSSRRPPAESWVASPWSSTDDRSARGEDLEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL6</accession>
    <name>W4TKL6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69336">
        <property type="protein sequence ID" value="GAE69336"/>
        <property type="gene ID" value="JCM18909_2540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16_C" evidence="1">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="23129" checksum="AE30FB334AF9BD38" modified="2014-03-19" version="1">MALADKYLGAVPAATGDLPERIQGQVRHDNPRVVVTRPLPRTAVTRAWATPPITNPDNLTVAMATDILGSEMSSRLIRTLERERHLVDGVGMNDFGLARGASAALVSAHLKPGVSEEELTGAVDEIITELAANGPSQAELERARAQVERSWLESLAVVDERADLLNMHESLLGDAALVNTHLDRIRAITADHIAEAARRWLSPHQASTVVHQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ8</accession>
    <name>W4TKQ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-tyrosyl-tRNA deacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69003">
        <property type="protein sequence ID" value="GAE69003"/>
        <property type="gene ID" value="JCM18909_2182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="6660" checksum="C05A1113B01A321C" modified="2014-03-19" version="1">MRVVIQRATSAEVVVEGRTVGSLTTPGLVVLVGVTGTDTATTAEKTGRESVGVAHPGRGEICQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT8</accession>
    <name>W4TKT8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin-guanine dinucleotide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69038">
        <property type="protein sequence ID" value="GAE69038"/>
        <property type="gene ID" value="JCM18909_2220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10541" checksum="928737F0F8DC999A" modified="2014-03-19" version="1">MAASRGLLFLAGRIVGTLRCVGWSYWSETLVKSVAGGLLWIGMRHDHDMTNRRLDAVILAGGCAHRLGGVSKANLRVGTRRLLDVVLDAVDGAREAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW9</accession>
    <name>W4TKW9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S-ribosylhomocysteine lyase</fullName>
            <ecNumber evidence="5">4.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">AI-2 synthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Autoinducer-2 production protein LuxS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_2837</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17753"/>
            <dbReference type="ChEBI" id="CHEBI:29484"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LuxS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.21" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69600">
        <property type="protein sequence ID" value="GAE69600"/>
        <property type="gene ID" value="JCM18909_2837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043768">
        <property type="term" value="F:S-ribosylhomocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037005">
        <property type="entry name" value="LuxS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003815">
        <property type="entry name" value="S-ribosylhomocysteinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02664">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE69600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5811" checksum="378501BB5714FBBE" modified="2014-03-19" version="1">MATLRDILKLDTTPAANEVQCEWGTNHSLKPAQEAAHTMLNHRDHWKQVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL24</accession>
    <name>W4TL24_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="9" type="ORF">JCM18909_2332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TL24"/>
    <dbReference type="EnsemblBacteria" id="GAE69143">
        <property type="protein sequence ID" value="GAE69143"/>
        <property type="gene ID" value="JCM18909_2332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13701" checksum="A9CA83676D1A07EA" modified="2014-03-19" version="1">MASTLTVRKSLSDRAKARARRQARGRKKIFGTVERPRMVVTRSSKHVFVQVIDDVAGNTLVSASTMEAELREMSGDKTAKAARVGTIIGERAKAAGITKVVFDKAGNQYHGRIAALADAAREAGLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL29</accession>
    <name>W4TL29_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69148">
        <property type="protein sequence ID" value="GAE69148"/>
        <property type="gene ID" value="JCM18909_2337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="OppC_N" evidence="4">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18532" checksum="767139C09F38F051" modified="2014-03-19" version="1">MSEPTNNSSVELNTPKVGPRAPIEGPDALTASERNEKHRPGRNERDGKHMSRGRLILRRFWRPVGSKVGVIGLALVVLLAAIGPYIANWDYWVVDDNAFLSPPDQYHWFGTSQGGFDLFAMTVEGLRKSLIIGFLCCPDRRDPGRSHWFRGSVFRQDGGKGHPLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL33</accession>
    <name>W4TL33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69153">
        <property type="protein sequence ID" value="GAE69153"/>
        <property type="gene ID" value="JCM18909_2342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="38" mass="4308" checksum="2EE7A5608E505B15" modified="2014-03-19" version="1">MTLPLYRRMSFTAVPKNLANFGASTFQTVRAEDIGFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL49</accession>
    <name>W4TL49_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68889">
        <property type="protein sequence ID" value="GAE68889"/>
        <property type="gene ID" value="JCM18909_2060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6231" checksum="8DD8AB0C2502C3F8" modified="2014-03-19" version="1">MLDEDIESVLGVRPDMTIKDDRRLARGQGDGEAPWVVASRRWRSGCAELVDQVMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL90</accession>
    <name>W4TL90_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69208">
        <property type="protein sequence ID" value="GAE69208"/>
        <property type="gene ID" value="JCM18909_2401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="257" mass="28474" checksum="53F960A497C10C48" modified="2014-03-19" version="1">MMRFSKRPPVDAQAVEDASGAVLYARDLNAQGRKGMIFGPLDMDLAPRQLAVIHGPAGAGKSALLLALCGRFRRTRGTLIIDGIDAMAEPYRAIQRTSVARIADYVVPEDRLTLNESVAERCHLDAANLKKAESRVRQIEEIVGFRIDRSCEFEQLEAIERAVASVALAMLRQTKVVVIDDADVMVPHSQQKLLFEIFSRLTELDDSTIIAATVDDDMAPPDPWTWNCRLTTVSMLSGISTLTRMLMAIPKILKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA6</accession>
    <name>W4TLA6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA-specific adenosine-34 deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69526">
        <property type="protein sequence ID" value="GAE69526"/>
        <property type="gene ID" value="JCM18909_2751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10314" checksum="7B2E130EBEF9D139" modified="2014-03-19" version="1">MTQALDVARRVATWGDVPIGAVILGADGEVLSEAGNERERTGDPTAHAEVLAIRRAAEARDGWRLGDCTLVVTLEPCTMCAGTIVAARIPRVVFWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK1</accession>
    <name>W4TLK1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin-guanine dinucleotide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69039">
        <property type="protein sequence ID" value="GAE69039"/>
        <property type="gene ID" value="JCM18909_2221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17129" checksum="5B5CEA730611144D" modified="2014-03-19" version="1">MKLEGSNVVVARESVEVPWSVIRTMEDPPGSGPLAGIRAGLQALPPAQPDDLVLVCAVDSPGIGRSIRQLREALEDDPLNHFAGAVTFGGVPKPHRQFLQGLYRRVPLEASIAAAGTVVNRSVHSVLGGLCLLDLPVESEACRDLDTPGDVEWWLRHIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM9</accession>
    <name>W4TLM9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69656">
        <property type="protein sequence ID" value="GAE69656"/>
        <property type="gene ID" value="JCM18909_2901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17509" checksum="3164709D7148EF15" modified="2014-03-19" version="1">MVLTVSPFTLVGMGVRMVLGAFGAHQAAAAVIPIAQAIGVLVGVFLLVVMAVRLLPRKPLSFLALGFLAVALCAPALHSWYVLWGALLLPLIDEAARFVRPAVWTTVIMLSFDAVNLSWRNSAAALGVALVLVLAARLVWHEHSLGQGWTHKDVHVPHPHKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ3</accession>
    <name>W4TLZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69547">
        <property type="protein sequence ID" value="GAE69547"/>
        <property type="gene ID" value="JCM18909_2774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6220" checksum="005FAFFE5282C33E" modified="2014-03-19" version="1">MSPEPPIRGFIIAGVLSIVGAVLMIISIAKSWHEVVTIIFIAVLACGIALAVTAACPWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM04</accession>
    <name>W4TM04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase PriA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69224">
        <property type="protein sequence ID" value="GAE69224"/>
        <property type="gene ID" value="JCM18909_2418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="23999" checksum="01CCBC407A24EFDA" modified="2014-03-19" version="1">MGATTTAAELGRAFPDVPVVDSSGNHVRERVDSTPRLIVATPGAEPAPESGYACAVILDAVSSLSRPGLAAVEQTVDRWMAILALVRSVRDGGRAVIVGPSEDAALQAMVRNDPVGWATRELADRREARFPPAVPCGIVDGDPKAVASAAQRLREWFGTNLEMLGPAPQPRRASESERDRIIVRPRGTMPLAELSQGLFRLRSKHTMSREPGSLRVVIDPANLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA0</accession>
    <name>W4TMA0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kup system potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2759</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69533">
        <property type="protein sequence ID" value="GAE69533"/>
        <property type="gene ID" value="JCM18909_2759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="317" mass="33870" checksum="6E5BDBFC545BF4E9" modified="2014-03-19" version="1">MTALLLGIVGAGLFYGDSFITPAISVMSAVEGLTVANPDAEKIVLPASVVILTLLFIVQRRGTEVIGKAFGPVMATWFLTLAALGIPWIIHHPVIITALSPHWAILFSIERPAMAFIAMGAVVLTITGAEALYADMGHVGAPSIRLAWFGLVLPCLLINYLGQGAMILSHPDWIDNPFFRMAPDWATIPLVTIATMATVIASQAVISGAFSMSSEAARLGLLPRLAVRHTSKSEGGQIYIPEVNWTLFIGVLALILIFQTSSKLATAYGLAVTGTFLLTTSLFLVLAHRAWHWPMWLSSSLVSLSAASSCRFSPPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD7</accession>
    <name>W4TMD7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69354">
        <property type="protein sequence ID" value="GAE69354"/>
        <property type="gene ID" value="JCM18909_2562"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="SSF48613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TENA_THI-4" evidence="6">
        <location>
            <begin position="257"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="418" mass="45169" checksum="EBEF77E3657F1CCB" modified="2014-03-19" version="1">MRIDAVKTGMLGTAEIVDAVAAFLDEHRPPVVVVDPVMVATSGDRLLASDAEAAMREFCRRATVITPNIPELAVLCQSEPATTPKQAVEQARRWAAETGVAVVVKTGHLNSQRVDNMWVTPEGAMHTVPAVRVETTNTHGAGCSLSSALATRLGAGDTPGDALAWVTDWLHEAIQYGSALNVGKGHGPVDHSHRARRLAEDASAVAWFAPIDPLESPQRLVVSAEPAPDAVVAPVGPWTTALWQASGDIARRIEASDFVAALVDGTLSKSAFEFYLGQDAQYLTYYSRALASLAARAVDPEESVWWAQSSQACLVEEAELHRSWLGDHIDVVAGPVTLAYTDFLLARALGDDYVVGTAAVLPCFWLYAHLVPRFRTFPTATLTPHGCRPMGIPSSSRGRHTPSVWWRKLPERLRRHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME3</accession>
    <name>W4TME3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69886">
        <property type="protein sequence ID" value="GAE69886"/>
        <property type="gene ID" value="JCM18909_3151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="11951" checksum="4842B1912DADDD86" modified="2014-03-19" version="1">MTQHGFGGVGGTMTTDIRSRLPRDQQAKTSRCANGATYVDARANGVLYRARHHPEPLALELPIGSSVIPAIAVVLGNAADRRTTDTLPSRQDEEPHGELGPAITIHGEVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG2</accession>
    <name>W4TMG2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsT</name>
        <name evidence="9" type="ORF">JCM18909_2976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69727">
        <property type="protein sequence ID" value="GAE69727"/>
        <property type="gene ID" value="JCM18909_2976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9997" checksum="3F707FDF44028738" modified="2014-03-19" version="1">MPNIKSQIKRVKTNEKSRQRNKAVKSALRTYVRNFRRGAEAGDVEAATKAARVANRQLDKPHRRALFTRTRPPTASRPFPKKLNSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR2</accession>
    <name>W4TMR2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70001">
        <property type="protein sequence ID" value="GAE70001"/>
        <property type="gene ID" value="JCM18909_3279"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13236" checksum="4BDBD6A8F8E47199" modified="2014-03-19" version="1">MGPPPAQWPALKGNPAELTIYDYVQRADDPRGIATLKGRKLTMIGFVSAAPEDPAHAWVLARLKMWCCVADALPFMTTMVGAPSRPTGGSWIRVTGTYLPNTRFKVERIDQIPVPENPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN57</accession>
    <name>W4TN57_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69952">
        <property type="protein sequence ID" value="GAE69952"/>
        <property type="gene ID" value="JCM18909_3225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8479" checksum="75F56F5ECEE2CBF5" modified="2014-03-19" version="1">MSIAQFGSTQMLSTLAMDAVIVGLIVCCAVLYMMWLLIRHRVLMRRRGAFFMRSSRDGWPQAGRLDDWERSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA5</accession>
    <name>W4TNA5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-xylulose 5-phosphate 3-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69699">
        <property type="protein sequence ID" value="GAE69699"/>
        <property type="gene ID" value="JCM18909_2948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="4"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="23738" checksum="46BB68199DF41410" modified="2014-03-19" version="1">MSACRYIGVLAGSADPAVRQRAREVMAEGLQLCHDLGAPVLQVAGYYCYYEQMNDHAEQWYTDLLLDAVPMAARLGVVMGIENVDGTDVTSIRKAMEFVKLADSPYLQVYPDLGNIAEQQLDAVTELEAGRGHMVAIHVKDVRPGEPRRVPMGEGTVDWDESFAVLAEQGWRGRMMIEMWNDDAPDSNARSASARQFIEEHLRTAGIPVRRALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF3</accession>
    <name>W4TNF3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70067">
        <property type="protein sequence ID" value="GAE70067"/>
        <property type="gene ID" value="JCM18909_3352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9121" checksum="6008A40BAD5EEBE3" modified="2014-03-19" version="1">MSGATAKVTVVGSINADMRVDVERFPGPGETLAGGEATLTPGGKGANQALAAARCGVQVEMVGAVGKDPTAETALSLLSEGVGLMAWSVVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN6</accession>
    <name>W4TNN6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uronate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70152">
        <property type="protein sequence ID" value="GAE70152"/>
        <property type="gene ID" value="JCM18909_3448"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="18144" checksum="3D76AD2A71C08627" modified="2014-03-19" version="1">MSAFFGVTERPSPENADRIYDTIAEQIAQPDFRPRALMNSFDIAFIATTDDPCDDLDGHARLAADETFTRRVAPTFRPDKYLEPAAGGWTGLLARLSEVSGCDATTLDGFTEAMENRRAYFKQHGAVSSDHSHRDLGTIILDHDRAASIFLTPRWQVGPLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNY1</accession>
    <name>W4TNY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000066">
        <property type="protein sequence ID" value="GAE70690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70690">
        <property type="protein sequence ID" value="GAE70690"/>
        <property type="gene ID" value="JCM18909_4068"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13603" checksum="EAA71AB2DA946504" modified="2014-03-19" version="1">MVLLAPVVMGAAKFNYGMEIRDEDHVRSTFVYGVSRADLEEAGKKPSDFSDCDKTFDVSASDKQHGAKAEFVEDKEYVGCKFTMTTTADDARGAGLGLTFDADKVSLSIGRKFFSRMLGLIKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ0</accession>
    <name>W4TNZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70421">
        <property type="protein sequence ID" value="GAE70421"/>
        <property type="gene ID" value="JCM18909_3739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11972" checksum="63A8014427C231B8" modified="2014-03-19" version="1">MLSLTNPKIMHTQKNAAFSGKTFIVYFAPLIVFPIAGYALGVFRSVLAFEDRFIIFKMSLASITALFACVITWLCFSGILGMVFFSSRFDGCSYVGTALSNDSNLGEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP38</accession>
    <name>W4TP38_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome aa3 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_3475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70178">
        <property type="protein sequence ID" value="GAE70178"/>
        <property type="gene ID" value="JCM18909_3475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE70178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="9110" checksum="ACF5565CB6A77629" modified="2014-03-19" version="1">MKATPSPRASISRPFFIATGFHGLHVTGGLVLFLFTLARTYMARRFTHEQAVTAMVVSYYWHFVDVVWIILFSVIYIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP65</accession>
    <name>W4TP65_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70506">
        <property type="protein sequence ID" value="GAE70506"/>
        <property type="gene ID" value="JCM18909_3834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12152" checksum="1316855DF653CE3B" modified="2014-03-19" version="1">MANSSRLGRVVSLSTVHHGHDNRVFNKEAKALVAAGHDYHLVISADRDGIDQGVPVVALHREEGRVRRLVVSQREAWRHLQASSPKCCIFTTRSSFRWHWCGVGATAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP85</accession>
    <name>W4TP85_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70009">
        <property type="protein sequence ID" value="GAE70009"/>
        <property type="gene ID" value="JCM18909_3288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="27596" checksum="C0EC9AB846968AF4" modified="2014-03-19" version="1">MHWHVLTAGVFDATQMEDFGAASGHFEHLLVGDLRNASGTLDDPWISSKDAVDVRVDLAKKSAPRELARATAVVSDAPRPRVVTSLVVWETPWNPATMTRSPASKDFSIRPGVMSIMRALPWAAVVITPAWEPVYERAGIPTSDRAIASRAADCRSPVVRSMSSSRGAGCGETSKARSIRSSVVSPIAEMTTTMSLPACFVAAIRRATRLIDAASATEDPPNFWTTRVINPPARFGHQSLTGDSTATPPYTGAPQSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK3</accession>
    <name>W4TPK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-damage-inducible protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70343">
        <property type="protein sequence ID" value="GAE70343"/>
        <property type="gene ID" value="JCM18909_3657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="12908" checksum="776E16841AB1A312" modified="2014-03-19" version="1">MVRGGRDPGSEAEAGYRQILNLAVPAFLSLVAEPLFLVADSAVIGHLGTAELAGLGVASAALTTFTGLFCFPCLRDDGNIVTSNGGGGSSGSCPGWCGWLVAVCHHWSARGDHAGGYSSDGGWLVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPN9</accession>
    <name>W4TPN9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ChlI component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70189">
        <property type="protein sequence ID" value="GAE70189"/>
        <property type="gene ID" value="JCM18909_3487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8805" checksum="F519E7346158151A" modified="2014-03-19" version="1">MAQRPVYPFCAIVGQEEMKLALILATISPDLSGVLIRGEKGTAKSTAVRGLAALLPQHREIPGPYHLSPDEYPGPRGRTQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPS9</accession>
    <name>W4TPS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70532">
        <property type="protein sequence ID" value="GAE70532"/>
        <property type="gene ID" value="JCM18909_3870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="10862" checksum="6FD47AACA29CF322" modified="2014-03-19" version="1">MREFMRSAPPWLWRFFSGGGVGDGCVEGAYAGQGPDAGGDFGVPGIGVRAAAGGLVLVGDGVTGFVADDVEAFDVGGDVVGVVDDGGGDGVGGRHLADGHAQHVFSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPT4</accession>
    <name>W4TPT4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70239">
        <property type="protein sequence ID" value="GAE70239"/>
        <property type="gene ID" value="JCM18909_3537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021441">
        <property type="entry name" value="DUF3090"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11290">
        <property type="entry name" value="DUF3090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03847">
        <property type="entry name" value="TIGR03847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19816" checksum="93D446E3C0E92A98" modified="2014-03-19" version="1">MVVGTVGQPGARVFHLQVREGSRVVTVRCEKVQIDQLALQMDRILDGLAAHVADVFVPPSVDNPDDLAPLDAPLEEEFAVGTVAMAFDDETKRIEIEMYAASDDELMIKDPAMLLTTLPEAAPDSLEILMTTSQARQFVARCRVVVASGRQYCPYCSQQILSAEGHLCPRSNGYRKPLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ23</accession>
    <name>W4TQ23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70637">
        <property type="protein sequence ID" value="GAE70637"/>
        <property type="gene ID" value="JCM18909_3997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6802" checksum="BB4825C3FFE83AF4" modified="2014-03-19" version="1">MVALMLFVIQPWMSFFGCNGQAFFKFFIKFSGSFYLPAHRLHSSHSLLMGREWWPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ53</accession>
    <name>W4TQ53_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70359">
        <property type="protein sequence ID" value="GAE70359"/>
        <property type="gene ID" value="JCM18909_3674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17595" checksum="BC93E45C4D83729E" modified="2014-03-19" version="1">MTEIAIHPETRAAWAKRLRRLRRALVPHRPKAFRDSLNRWLLMGTVIGIVSGVGAIIFFFCLKTGTHWLLETLGGYTPPGTLGEGGGVAGTRLTRPWAIPLVVAGGALVSGTLVYFVAPTAKGHGTDNAIHAVHHDPTALKGKVAAVKIIASSRDRFRRFGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ55</accession>
    <name>W4TQ55_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000063">
        <property type="protein sequence ID" value="GAE70672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70672">
        <property type="protein sequence ID" value="GAE70672"/>
        <property type="gene ID" value="JCM18909_4047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13197" checksum="B6F3231421E71AAF" modified="2014-03-19" version="1">MRGGFVATPQGDVAARLLLGHGEPTQCHRPQVLDLVAEFHEGGDVVAAGATSELLAPVLDVFDALRHQRLGLLGVGARPPAGGGHEEVRDAAVGLRRVHCVVVQSNGQVGERNISWRGWSARPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ93</accession>
    <name>W4TQ93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70394">
        <property type="protein sequence ID" value="GAE70394"/>
        <property type="gene ID" value="JCM18909_3712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="14669" checksum="C1865569D7FC8A2E" modified="2014-03-19" version="1">MGREGVIAGCKDSSADDVSFRRLALANRAAGSPLSLFTGHEVVVDGAFMSGADGVVPGLANVDATSYVAMYKAYREGDWKTVRIEQDKAAELMEIAFAPQGVVGPAAGVGAFKTAMQLLGTIETNTMSVPLPTLTGITSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQL1</accession>
    <name>W4TQL1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000068">
        <property type="protein sequence ID" value="GAE70698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70698">
        <property type="protein sequence ID" value="GAE70698"/>
        <property type="gene ID" value="JCM18909_4078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11086" checksum="8C8457F2B433E44E" modified="2014-03-19" version="1">MVVPLVAKKGNTSGVVVKVDPASLSRMLGGEWGQPGEALPEALADALLDLIDAGFLPAGAVLPPQRACAATLQVSRQTVAEAFGILEAAGTLRRWLGQGRGLDQAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQR4</accession>
    <name>W4TQR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70574">
        <property type="protein sequence ID" value="GAE70574"/>
        <property type="gene ID" value="JCM18909_3924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5796" checksum="F82E4FEA5F920F26" modified="2014-03-19" version="1">MPAGTHHRSRARRALEQKQTSMSQQGTLQDLHILAPVMTQVDDKAGGKSLQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDI2</accession>
    <name>W4TDI2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="4">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="4">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pdxT</name>
        <name evidence="7" type="ORF">JCM18909_35</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="4"/>
    <dbReference type="EC" id="3.5.1.2" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67005">
        <property type="protein sequence ID" value="GAE67005"/>
        <property type="gene ID" value="JCM18909_35"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="42"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="4 6">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4 5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="195" mass="20664" checksum="DF098E4A0F3E058A" modified="2014-03-19" version="1">MVALQGGFAEHIEVLESLGANTRRVRRGADLQGLDGIVLPGGESTVIDKLMRSFSLAEPLKDAVRRGLPVLATCAGLVVLAADLEDAAKGQQTLGLLDVTVRRNAFGSQLDSFEGTLDIDGVGDGVSATFIRAPVVTRVGSGVEVIAQLPDEAGNVSGAIVGVRQRNVLALSFHPEETDDDRVHRTWLRQVSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDJ9</accession>
    <name>W4TDJ9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_50</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67020">
        <property type="protein sequence ID" value="GAE67020"/>
        <property type="gene ID" value="JCM18909_50"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850685" description="VWFA domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="21812" checksum="B17482AB910F589F" modified="2014-03-19" version="1">MGDLPPRFNVSLVKFAASAQVVVPPTTDRAAVSTAITNLQVLPSTAIGEGIYSSLNALKLVPDDPKHPGQKPPAAIVLLSDGATNVGRPSLEAAKEAGRQHVPVYTIAYGTAGGYVVEGGQRQPVPVNHYELAAIAKASGGEKFSAESLGQLSDVYKSIAQSVGYEKVFGEVTDKYVGVALALVVLTAAPSSVYAPVGLIPCLQSRFVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE18</accession>
    <name>W4TE18_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67205">
        <property type="protein sequence ID" value="GAE67205"/>
        <property type="gene ID" value="JCM18909_248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13119" checksum="E2C1BB878460BD89" modified="2014-03-19" version="1">MDLGIDLGTTYAAVAAMEFTLRQERNLFVDLDSTILHIPRVEVARACTPLIDRTIETMKPLSSLLNDADSDIASIHLVGRATSLPIIRAVCVSYVAERCTAPLIRRCNRHRLGCRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEP3</accession>
    <name>W4TEP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_21</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66992">
        <property type="protein sequence ID" value="GAE66992"/>
        <property type="gene ID" value="JCM18909_21"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE66992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8068" checksum="4551C5E3CBFFAA23" modified="2014-03-19" version="1">MLREEPDRDYAEAYAARVRLLSITDDIANLKSRLQRTNPNQDRKLYNAMFSDLVTLEALRKSLIVAGGAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEU6</accession>
    <name>W4TEU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67316">
        <property type="protein sequence ID" value="GAE67316"/>
        <property type="gene ID" value="JCM18909_363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10388" checksum="58D5C37614EF1349" modified="2014-03-19" version="1">MKRIDARVRDLERQVHSAEEAEWKRTDPQARERARATVDMFSAHIDKLNAQVEKAEAAGRTKDADKARESIKTYQTWLDEAQKALDEFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEZ4</accession>
    <name>W4TEZ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67530">
        <property type="protein sequence ID" value="GAE67530"/>
        <property type="gene ID" value="JCM18909_595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTRA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12115" checksum="617106F717FDB643" modified="2014-03-19" version="1">MAVEKTWIAVRVMPDLLTHGVPASIYGAMAAAGLVPTWGEDAIEAVSGDALVCEHLQIPVGSAVLAINRRTYADDTAISYSRSWYRGDRYKLWVPISGPRRTLYPPRGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF33</accession>
    <name>W4TF33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67570">
        <property type="protein sequence ID" value="GAE67570"/>
        <property type="gene ID" value="JCM18909_641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8533" checksum="68379D870E75B069" modified="2014-03-19" version="1">MGSRGSMFGFVGPNGAGKTTTLSMVTGLLRPDTGRVEVLGHDVWADPAAAKAQMGVLPDDEDLRPSLWPRATPLLRDATPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF80</accession>
    <name>W4TF80_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycine cleavage system H protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67187">
        <property type="protein sequence ID" value="GAE67187"/>
        <property type="gene ID" value="JCM18909_230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14534" checksum="9006723BA5221D33" modified="2014-03-19" version="1">MEVVMTEIPDDVLCTSDHLWIRPGNGSRVRLGVTSVLLDHFGPVESVSLPDDGEEVVSGDSCGDVEFSARTWEIISPVAGEVVAVNPSIDADQVEADPWGDGWLFDVRLSDPEQLDELLDPDEYLASVGEVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFG3</accession>
    <name>W4TFG3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67173">
        <property type="protein sequence ID" value="GAE67173"/>
        <property type="gene ID" value="JCM18909_215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16062" checksum="BCD7F6059EB79FC2" modified="2014-03-19" version="1">MLSRSLRKAKFAEKLGATRTLATSDDNFFRDHRGEFDFILNTTSAPIDVSAYLKLLKPRSVMACVSLPPEELGLRVGSLNNGSKVLAGSNIGGIPQTQEMLDFCAEHHLGAWVEKIGVDEVDAAYDRVVAGDVRFRFVIDTTTFGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFI1</accession>
    <name>W4TFI1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67725">
        <property type="protein sequence ID" value="GAE67725"/>
        <property type="gene ID" value="JCM18909_805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="277" mass="29069" checksum="BEA843FD94D43D34" modified="2014-03-19" version="1">MVLFVGGSLLAATASGPGSLIASRTVQGVGGALVLPSTLSSVNSLFQGKDRAAAFGIWGAVMSGMAALGPLLGGVLTEYASWRWIFWVNLLLGLLVLAGIAAWVPQTHGKPADKGVDVDGVLTSAIGFGLLVFGLIEATTLGWWDKKQTFKVFGWEWPTSWSMSPVPWAIAIGLVFIMLFVVWEHHRAKVGRDALLDLALFRVGTFSWGNLTAATVAIGEFSLTFVLPLFLVNSLGLSTVCTGIVLAAMALGAFFLRGVGTSPSREDGCRRGGPSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFR5</accession>
    <name>W4TFR5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate etherase</fullName>
            <shortName evidence="3">MurNAc-6-P etherase</shortName>
            <ecNumber evidence="3">4.2.1.126</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-acetylmuramic acid 6-phosphate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murQ</name>
        <name evidence="5" type="ORF">JCM18909_324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N-acetyl-D-muramate 6-phosphate = (R)-lactate + N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:26410"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58722"/>
            <dbReference type="EC" id="4.2.1.126"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylmuramate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.126" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67278">
        <property type="protein sequence ID" value="GAE67278"/>
        <property type="gene ID" value="JCM18909_324"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00342"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016835">
        <property type="term" value="F:carbon-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046348">
        <property type="term" value="P:amino sugar catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097173">
        <property type="term" value="P:N-acetylmuramic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05007">
        <property type="entry name" value="SIS_Etherase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00068">
        <property type="entry name" value="MurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005488">
        <property type="entry name" value="Etherase_MurQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005486">
        <property type="entry name" value="Glucokinase_regulatory_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040190">
        <property type="entry name" value="MURQ/GCKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088">
        <property type="entry name" value="PTHR10088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10088:SF5">
        <property type="entry name" value="PTHR10088:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00274">
        <property type="entry name" value="TIGR00274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01272">
        <property type="entry name" value="GCKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="4">
        <location>
            <begin position="35"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="28937" checksum="F41942CD29125732" modified="2014-03-19" version="1">MPTLDVLRLMNDEDHRVPDAIASQLPAIAAVVEAAVKGLSAGGRLIYAGAGTSGRLGVLDAAECPPTFSTNPTMVVGLIAGGQQAMFQAVEGAEDDADRGAEELNMLQPGPHDVVVGLAASGRTPWVVGVVRAAKRAGAVTASVCCNHRAVISSEVDLPVEIDTGPEVLTGSTRLKAGTAQKLVLNMISTATMVGLGKTYGNLMVDVSPSNEKLRQRAMSIVMAATGCSCDDAITALHEAGGHAKTAIVMVLLGMAATQARARLAEAGGVVRVAVDENHLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG41</accession>
    <name>W4TG41_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein TypA/BipA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67910">
        <property type="protein sequence ID" value="GAE67910"/>
        <property type="gene ID" value="JCM18909_1004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="5"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="483" mass="53044" checksum="6C4A31BB989AD1C0" modified="2014-03-19" version="1">MPVRKDLRNIAIVAHVDHGKTTLVDAMLWQSGAFREGAEVEKRVMDSMDLEREKGITILAKNTAVKHVMSDGEEITLNIIDTPGHADFGGEVERGLEMVDGVILLVDASEGPLPQTRFVLRKALAKKLPLILVLNKVDRSDARIDEVVEETYDLFMDLSDDDDASLLDVPVVYASAKAGRASLNKPGDGELPDSPDLQPLFDCILENIPAPTYDEGGVLQAHVTNLDASPYLGRLALCRVVSGELTKGQTVAWCKRDGSVQNVKLSELLMTEALERVPAEKAGPGDIVAIAGIPEITIGETLSDPENPVPLPLIHVDEPSMSMTIGINTSPLSGRSGDKLTARLLKARLDQELIGNVSIKVADTDRPDMWEVQGRGELQLAVLVEQMRREGFELTVGKPQVVTKTIDGKLHEPFERVTIDAPEEFMGPVTQMMGLRKGQMMHMVNHGSGWVRMEFVVPAWPYRLPHRVPHPDPRSGHHEPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG58</accession>
    <name>W4TG58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67134">
        <property type="protein sequence ID" value="GAE67134"/>
        <property type="gene ID" value="JCM18909_174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025329">
        <property type="entry name" value="DUF4235"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14019">
        <property type="entry name" value="DUF4235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10846" checksum="773AB3ED713F2C54" modified="2014-03-19" version="1">MIPEKILWKVYAGALGAVTTIVSQKVVEGVWKYVTGDEETPQPDDPEISTTKALSWALASGIGIAGSQLLMHRFVNKRWMKFSAVNPITGKNLNAEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGD2</accession>
    <name>W4TGD2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protoporphyrinogen IX oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68015">
        <property type="protein sequence ID" value="GAE68015"/>
        <property type="gene ID" value="JCM18909_1121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9628" checksum="5B7F4D5C0D0A7532" modified="2014-03-19" version="1">MSVDQALADASVLLGVDLSAEQVVDSQIIHWTGSLAPTTPQTRAWRDGLHRQLEALNQSGRGRIGLVGAWASGSGIAALVAQARRTVRQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE6</accession>
    <name>W4TGE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67224">
        <property type="protein sequence ID" value="GAE67224"/>
        <property type="gene ID" value="JCM18909_269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="5">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="19454" checksum="B88092E729636BC6" modified="2014-03-19" version="1">MTIPAFDKIGLYSVAIAASFFTAMALVIVRDYRDNDEKAAAKARRRQASAHEAEPTTAAPAAATESITETATVEGAEAPTAAEVASEAVTITSPLEGRAVPISEIPDPVFSTGVVGDGIAIEPASNTVVCPADATVVTAPDSGHAFGLKLDSGVELLIHVGIDTVELGGKGFDVKVKAGDHVSAGQPLVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH2</accession>
    <name>W4TGH2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67881">
        <property type="protein sequence ID" value="GAE67881"/>
        <property type="gene ID" value="JCM18909_973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5642" checksum="CE34E80372C97525" modified="2014-03-19" version="1">MPSFFTYEIVLSKFYSVSKSDAGLYMIPFAVGNLLGPILLDDSLTPLVDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU3</accession>
    <name>W4TGU3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase 2 subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67981">
        <property type="protein sequence ID" value="GAE67981"/>
        <property type="gene ID" value="JCM18909_1084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21354" checksum="9B9792EB7DE973A4" modified="2014-03-19" version="1">MLVELDDAGQRRRLHRTLSEHPAVGTVDLVPAQTTVLIDVESPDQLPAAVAHIQELIAAGLDCVEQGAREVVEVPVRYDGLDLSDVAELLSMTTDELVRRHSDQQWTVEFAGFMPGFGYMSGADWPYRIPRRDSPRTRIPPGSIALADGFTGAYPQASPGGWQIIGTTDAILWDEKADPPALLLPGAVIRFEVVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGV6</accession>
    <name>W4TGV6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PspC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67658">
        <property type="protein sequence ID" value="GAE67658"/>
        <property type="gene ID" value="JCM18909_732"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="8">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="9924" checksum="7CA74DD2A116D1B4" modified="2014-03-19" version="1">MTKLIRPSEGRIIGGVCQGIANSLNLDPTVVRIVAALLILMAGSGPLIYLVLWAIIPDEGSGSSMVTDLADRTRCPHKSEGTQGSSAPFNPYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW8</accession>
    <name>W4TGW8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67389">
        <property type="protein sequence ID" value="GAE67389"/>
        <property type="gene ID" value="JCM18909_446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="7942" checksum="035D54A364CC42C1" modified="2014-03-19" version="1">MVILGPGASPAGHRNNGVAKGYEVSMAEQVVGQASTEVSMGEDVNVGKLSFPAMLSLVVGSMIGGGIFFASAEYCCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY9</accession>
    <name>W4TGY9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68036">
        <property type="protein sequence ID" value="GAE68036"/>
        <property type="gene ID" value="JCM18909_1142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like_dom" evidence="1">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8224" checksum="EC7604E965AD0017" modified="2014-03-19" version="1">MWRSSTTLPQKKAVFGQAVRARQEQGGGWMGWAVSVDDLAPYEKRLERQSVPGKRTFPDGRHLEWRQIGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH32</accession>
    <name>W4TH32_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68280">
        <property type="protein sequence ID" value="GAE68280"/>
        <property type="gene ID" value="JCM18909_1404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="237" mass="26595" checksum="22AA703133E6BC0E" modified="2014-03-19" version="1">MFGHTTRLQITDVPVAVLFILAVASIGIYGVVLAGWSSAGTYSLLGSLRSSAQMISYEVAMGLSLVTVFIFSGSMSTPQIVESQANHLVVGGFDTHIAGHYWLLLIPSFVIYVITMFGESNRLPFDLPECESELVSGYITEYSGFPYGMYFLAEYINMATLSAVCTTLFLGGYRAPWPLNYFGVIDSGWWGLLWFFLKTQLVIFFFVWVRAAIPRFRYDHFMDLGWKVLIRCRWGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH92</accession>
    <name>W4TH92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67504">
        <property type="protein sequence ID" value="GAE67504"/>
        <property type="gene ID" value="JCM18909_567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6552" checksum="7AD0979CAE9159FF" modified="2014-03-19" version="1">MVPFIPTASWEPGWRVPSLRPTNPIEKTTPSEFFRRRWIAFRDPLADENDRGPVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH99</accession>
    <name>W4TH99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligopeptide ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67808">
        <property type="protein sequence ID" value="GAE67808"/>
        <property type="gene ID" value="JCM18909_893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12387" checksum="839538E1A5640540" modified="2014-03-19" version="1">MFTQLIYPALFSYKLDAKNEFNIDERHSVAKPPPYPTTHSLTPSPLRTAHGATASSSLRATWSSGGTSSPTTPTSGRPTAKASSPTTSRLSRSLTTKPSPSPRLRSTTRHGSSTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF1</accession>
    <name>W4THF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA (Guanine46-N7-)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67584">
        <property type="protein sequence ID" value="GAE67584"/>
        <property type="gene ID" value="JCM18909_656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="236" mass="25211" checksum="8CEC7280680B4E35" modified="2014-03-19" version="1">MSKYSCSPTLDVDHRSIASAGEHFHHRVAQSHRLSFDPVRPDPAPLDPTDASPAQARHHQPGLGVEVSAGAHRSGDRVRRGVVSFVRRSPRMNVSQQRAMNTLASTYLIDVPRDATSTSVAPGSRLDLPAIFGRTAPLTVEIGVGSGDVLAALAVAHPERDFIGFEVYLPPSQRPSTSSRTLVQVTPGSSWPMPQQGWNTSSDPPTSTNCGPSSLIHGTRSVTTNVASSTPTQPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG1</accession>
    <name>W4THG1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68395">
        <property type="protein sequence ID" value="GAE68395"/>
        <property type="gene ID" value="JCM18909_1530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021903">
        <property type="entry name" value="DUF3515"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12028">
        <property type="entry name" value="DUF3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850754" evidence="1">
        <location>
            <begin position="33"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="21853" checksum="DC56034C80BE84C7" modified="2014-03-19" version="1">MRIYHASPVATLLVVFLLTTACSSRDEPIAHPSPSGPAAAGCRAVMADLPQTVAGATLNDHDTTVATWGDPHIVLRCGVDKPAGLQPTSPCDVVNDVGWFSEQIDDGWRFTTIGRAGNIEVTVPTSYAPQADAWSIFQQPLRKCPKYVLASEIHPDQRRPRGLSKANSMSSLTIWAYVMPLACHMSGNPELRVNPGMVLGSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK1</accession>
    <name>W4THK1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA:pyruvate transcarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67903">
        <property type="protein sequence ID" value="GAE67903"/>
        <property type="gene ID" value="JCM18909_997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PYC_OADA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15138" checksum="46BAA206D0DA9890" modified="2014-03-19" version="1">MGNGSYKNLTAEFADLMLGYYGKPIGELNPEIVEMAKKQTGKEPIDCRPADLLEPEWDQLVEQAKSLEGFDGSDEDVLTNALFPGVAPKFLKERAQGPKSVAMTEAQLKAEKEGTGAAGIAGPVNYNVTVGGNSHQVTVEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL7</accession>
    <name>W4THL7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ErfK/YbiS/YcfS/YnhG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67908">
        <property type="protein sequence ID" value="GAE67908"/>
        <property type="gene ID" value="JCM18909_1002"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850756" evidence="4">
        <location>
            <begin position="28"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="67"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19721" checksum="C1EE3F930BFD71A3" modified="2014-03-19" version="1">MRSSRAASLAAALVMSLSAGVVGVANAEPTASSPDPRQSSPAVAPPATLPISNTGAHLDRRCMRGTVICASKKQRKLWMVHNGRILITLDARFGRASEPTAEGVHTIYWKDKKNHVSSIYGSPMPYSMFFHKGQAIHYSSDFSRRGWNGASHGCINIRNMSGLKWLWDRTPTGRKVIVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW0</accession>
    <name>W4THW0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68107">
        <property type="protein sequence ID" value="GAE68107"/>
        <property type="gene ID" value="JCM18909_1221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5210" checksum="B2362A22AA75CCF1" modified="2014-03-19" version="1">MAPSALAVVGGFITFVVEEGFDIVGDTSRDDEALLGSQDKAFCPVGLGGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX3</accession>
    <name>W4THX3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68540">
        <property type="protein sequence ID" value="GAE68540"/>
        <property type="gene ID" value="JCM18909_1686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="32"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11771" checksum="E6CFC8E17E542385" modified="2014-03-19" version="1">MNNVIEVTDATFVSEVLGVSKPVLVDYWADWCAPCKQLSPIIEELAGTYGDRMVFAKVDTNANTRVAAEQGIMSLPTIQVWQGGQLVKSLQGGKTKKALVKIIEEFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI37</accession>
    <name>W4TI37_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68620">
        <property type="protein sequence ID" value="GAE68620"/>
        <property type="gene ID" value="JCM18909_1767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="16560" checksum="55CC65669494A086" modified="2014-03-19" version="1">MSALSQPVVQRSGIERRTRVRVISTICLVIIVCGLVLLSAMVGQYRVEAADVIKIVFGGSATDAMAESVLWQIRFPRIVLGLLVGASLAVAGAVMQALFSNPLAEPGVIGVSSGAAVGASIMIVVAPNFFVRVRGAGSGICIRTACGQFGLHYGAVRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI67</accession>
    <name>W4TI67_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Solute-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68227">
        <property type="protein sequence ID" value="GAE68227"/>
        <property type="gene ID" value="JCM18909_1350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8648" checksum="67DC13AA46728579" modified="2014-03-19" version="1">MYKQMNEDTLISELYGIWDTALIAQNVSKGKGKWAVAPLPEWPDRPGGATWRISHSGAQGFKERRSGREVRHVDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIA2</accession>
    <name>W4TIA2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GlcNAc phosphomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68491">
        <property type="protein sequence ID" value="GAE68491"/>
        <property type="gene ID" value="JCM18909_1633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="166"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="270"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="474" mass="53318" checksum="04C8B57BC6377637" modified="2014-03-19" version="1">MADEIEFGTGGWRAIIADTFTRLNVERVAQALADRIHDENQEHRPVVIGYDQRFLSPEFAWWAAEVLAGNDIVVRIIDRPAPTPMIMWTIRDLGCAYGMAVTASHNPATYNGLKVFTEGGRDAKVEITEPIQHRANSISPKDIRRVHRTDALRDGVIEVQTSMNWYIDAILDHVDLEAIRHAHLKVVLDPMFGVSRTCLQTILMTARCDVDTIHERRDTLFGGRLPSPNSRTLQTLAQEVVERGADIGIATDGDADRLGIIDDQGHFLHPNQILVLLYTYLLEDKEWQGPCVRNLATTHLLDRVAEAHGQTCYEVPVGFKWVSSKMAETNAVIGGESSGGLTVQGHIAGKDGVYAGTLLVEMIAKRGKKLSQIYADIEERYGRLEMVEDDFSFAPEDKEYLKRRIYQDKDLPDFGLEVDHISDMDGVKVYFANGGWIVVRFSGTEPLLRVFCEMPVAQMARECIDKVVKHYHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIE3</accession>
    <name>W4TIE3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitric-oxide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68203">
        <property type="protein sequence ID" value="GAE68203"/>
        <property type="gene ID" value="JCM18909_1325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="16417" checksum="EC497630008E5B6C" modified="2014-03-19" version="1">MERQAGENLVLVHEHRACWMVFVTLLPLGILQLYHSVDAGYFEARQLNYITEHRNVVLEWLRMPGDLVFIIGGVLPFLWMTFQGLMHHRRGGPSTSCRWSDSSSRRPRASKDMPSCRRRRGEPVPPGGAHLLLLPLSAYRGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH2</accession>
    <name>W4TIH2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68576">
        <property type="protein sequence ID" value="GAE68576"/>
        <property type="gene ID" value="JCM18909_1723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025327">
        <property type="entry name" value="DUF4233"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14017">
        <property type="entry name" value="DUF4233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13369" checksum="897539EC9BA1AEA5" modified="2014-03-19" version="1">MTLVAHPGAGKGGILILPAGNPMTKVVVSFLAFEVIVFGLAIPGMILVSGVSVVMSIILGCVGMVVSIVCAIGVPRTWGYLLSWTLQIFGILLGLATPMMYVVGIIFAAIWVSIMVLGKRIDGSPEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ0</accession>
    <name>W4TIJ0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ORF">JCM18909_1035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M41.015"/>
    <dbReference type="EnsemblBacteria" id="GAE67934">
        <property type="protein sequence ID" value="GAE67934"/>
        <property type="gene ID" value="JCM18909_1035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="53"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="541"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="571" mass="60970" checksum="9AC0433CF192CE84" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIL3</accession>
    <name>W4TIL3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68805">
        <property type="protein sequence ID" value="GAE68805"/>
        <property type="gene ID" value="JCM18909_1968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="4">
        <location>
            <begin position="40"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="3">
        <location>
            <begin position="257"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="340" mass="36984" checksum="3915AA7D7DAA08F8" modified="2014-03-19" version="1">MVANADTAHRLDDALTNLIPWHGPVAPRAHLHTDAPTLDLSGTWRFQLVDSPHDTPAGFPDPQFDDTDFVDLAVPSSWHMVDPAGNAPFGRPAYLNTNYPIPVPASDEDIVVPNENPTGCYRHTFEVGKDFTDAERVLLRFEGVDSFARVWFNGVELGWTKGSRLTSEFDVTSQLRPGRNVLAVAVSQWSDGTFLEDQDMWRMSGIFREVTLLARPHGGIDDLFVHASWDGDAKLLIDGPEGATVAIPELELATTCNTEVAIPDAQPWTAETPKLYDATVSTDTETVTIRIGFRSVAIAGDIITVNGEKKSYSVGLTATNGIHAPGEPSMSRRCALTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU5</accession>
    <name>W4TIU5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68711">
        <property type="protein sequence ID" value="GAE68711"/>
        <property type="gene ID" value="JCM18909_1863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="67"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30870" checksum="04C02832B3B5AA07" modified="2014-03-19" version="1">MGYPDPGSAALLKTAGSFFWDGQQVSRASVRVATGQMLDVDLCDPVATPSITPQIVEGMRIIHDDSDIVVVDKPAGVAAHPSLGWEGPSVVEHLAAAGFAISTSGAPERQGIVQRLDVGTSGLMVVAKSEHAYTLLKQAFRDRTVDKVYLALVQGHPDPFTGTIDAPIGRDHRHDWKMAIVDGGRHSVTHYETVEAFRHVTLLRVHLETGRTHQIRVHMAAIKHPCCGDPLYGCDPALAKELGLERQWLHAGELSFTHPGSGEWVTFYADLPADLQNALDAVRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ4</accession>
    <name>W4TIZ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68393">
        <property type="protein sequence ID" value="GAE68393"/>
        <property type="gene ID" value="JCM18909_1528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="48"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28094" checksum="A212B536E34D0B20" modified="2014-03-19" version="1">MALPAVTNPADTPGLIFRMGVGTLYPLARILTRFDHHGGENLPGPGPALIVSNHISNYDPVVLGAFLVANGRWPHWLAKKELFSVPIVGWVASASGQIPVDRKGPNPAKVLHDAKAALDKGMTVVMYPEGTITADPLHWPMTGRTGAARLALETGVPVIPVGQWGPQEVMGYKEMTFPKLWPRKTMKLYCGTDVELSDLRGRHDLASVREATNRIMDAIDAQVARARGEFPPPDRYDMRKGARIPKSIAPARPVVDPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ03</accession>
    <name>W4TJ03_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68512">
        <property type="protein sequence ID" value="GAE68512"/>
        <property type="gene ID" value="JCM18909_1655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8289" checksum="46C8578999F48B11" modified="2014-03-19" version="1">MLGKLPDTIRKIALDAGVPVWAVCGRCDLPEEKRRVFERIICLSDIEPDVEASMAQAGPLLSRAVEQAVREELGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ09</accession>
    <name>W4TJ09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68522">
        <property type="protein sequence ID" value="GAE68522"/>
        <property type="gene ID" value="JCM18909_1666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12306" checksum="51B929073F8092CF" modified="2014-03-19" version="1">MNADSGVPLTELRVDGGMTANETLMQFQADQVNVPVVRPVVAETTALGAAYAAGIAVGFWEGENDVTDNWAEDKRWEPKMDENERERLFRNWKKAVTKTFDWVDDDVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ18</accession>
    <name>W4TJ18_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68532">
        <property type="protein sequence ID" value="GAE68532"/>
        <property type="gene ID" value="JCM18909_1677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="264" mass="28591" checksum="6C192BBC43E58E60" modified="2014-03-19" version="1">MDAGGALMQTTEVENYPGFSEGIMGPDLMAQMRAQAERFGAELIADDVTDIDLTGEIKKLIDTDGNTYRARVVILAMGSAYRKLGLEDEPRLSGRGVSWCATCDGFFFTGKDIAVVGGGDSAVEEATFLTRFANSVTLVHRRDQLRASQIMADRAAADPKITFAWNSEIVAMQGESKLESITLRDTKTGEERQLEVTGVFLRPSAMTRAPSWYAARSIWTMPATSCALSRPPAPMCREFSPAATWSTPTTNKPSPRPGPGAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ21</accession>
    <name>W4TJ21_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation protein Maf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68791">
        <property type="protein sequence ID" value="GAE68791"/>
        <property type="gene ID" value="JCM18909_1954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18344" checksum="0E41AD0AE6B1FF2B" modified="2014-03-19" version="1">MTARLSRLKAHSVIESGALEEYPADRMIVVACDSVLNLDGRILGKPHTAERARQWWRQMRGHQGVLVSGHHVAVIVNGQLREQTRIGQTVVTFADLTDAEINAYVDSGEPAAVAGAFTIDGLGGAFITRINGDPHNVTGISLPLLRQMLMDLDVEWSSLWNGPKGGHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ27</accession>
    <name>W4TJ27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin-protein ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68796">
        <property type="protein sequence ID" value="GAE68796"/>
        <property type="gene ID" value="JCM18909_1959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="14"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="292" mass="30861" checksum="BBC695D5F0DD9285" modified="2014-03-19" version="1">MPSTPSPIADRVLELAGDTLFFTGPRGGGVTCIDSTGSTNADMAAFVRAGGTSFCLLVADHQEGGRGRFTRSWQDVPGTSLAISALVPNDRPSQDWGWLSMVAGLAVAKVIEEVGGADRSRVTLKWPNDVLVDLDTDQGGKVCGILSERVDGPAGPHAVIGIGINVSMGRDELPLPTATSLALCGLNHDKNELLASLLIHLDELLTVWFETGTVRDQYVARCDTIGTPVRLTFDPEIVGGGEGVIEASVSTLTLMALSWWKLLTGVAVSTLLTFIICEPGEFRYGVLSVPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ68</accession>
    <name>W4TJ68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68443">
        <property type="protein sequence ID" value="GAE68443"/>
        <property type="gene ID" value="JCM18909_1581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="330" mass="36484" checksum="73BFC0278671BDE4" modified="2014-03-19" version="1">MMVHARGLTLVEFSMRTTWRWPRDHDEGDLIVSEMDEVIPALVAAVQEQHAAGDHYRDDAIRQAMEHQAQLALRPGPVRVDVIVDPPWSDGQINSVQVVTGDRLFLVDTVVSCLLRHGWRVEDVRHPIIGVKRDRGTIEAVGMPGRGGCASESWIHIDATAPLGTDIRQAAEQLRDDLCACLDQVVCATDDWGAMHEAMLRTAELVSASSGPADDRDSSRELLEWLADDHFMYLSYQEFAVDGETMTPVAGTHLGIAEEGPRFDAVPHNDDKATVIVTKDSVRSAVQRNGYRDYIGVRIRDEHGAVVAEHRFLGLLGSAAYTESVAIFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG2</accession>
    <name>W4TJG2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69095">
        <property type="protein sequence ID" value="GAE69095"/>
        <property type="gene ID" value="JCM18909_2282"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="158" mass="16540" checksum="D357E0A48646CE0F" modified="2014-03-19" version="1">MVTVGFDPDQNSLSASQVRDGDTKDYGDLLDSQEIMYSAVGQTDLFIFPGNVPVGDYTLTFTDYGNTARTVRVHLDHGAGYLLSGDTPKSTPTPKPTPKPTPTPTSGERTVKPVPGAATTTATTVVTDGNDQGVVRVAGGIALCLILVSDSLNYSSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI4</accession>
    <name>W4TJI4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactate-responsive regulator LldR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68314">
        <property type="protein sequence ID" value="GAE68314"/>
        <property type="gene ID" value="JCM18909_1442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17748" checksum="882A97E3D36F7040" modified="2014-03-19" version="1">MNYWRLRINSPTRIPAMTQTRDAGSSRPDPHAGHQASVTHSSTASKSGGFSVVMRHIDDEILAGRWVNGSRLPPERELAASLSVSRGAVREAIRALEAQGILSSGTGRSNGTRVDARPSDAMGRILRLQLALDVVSFADLTETRVALEKKLPVLQLQRCAPLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM6</accession>
    <name>W4TJM6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68628">
        <property type="protein sequence ID" value="GAE68628"/>
        <property type="gene ID" value="JCM18909_1776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05829">
        <property type="entry name" value="Sortase_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042001">
        <property type="entry name" value="Sortase_F"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15632" checksum="666265114A3F5EFF" modified="2014-03-19" version="1">MKVSAKVLSRGVDETGAAGAPPKNDPSSMAWFNQGPKIGSDKGNAVLTAHTYHKGGALGNRLYDKNNGIKKGDIIRLTDKAGQTVCYRYDHDTKVMVKDYNPNSNILYDNNGPAQAAIVICWDYVKKTGEFDSRVIFYAYPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ9</accession>
    <name>W4TJQ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69190">
        <property type="protein sequence ID" value="GAE69190"/>
        <property type="gene ID" value="JCM18909_2381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7784" checksum="1A4A76BBD21B4690" modified="2014-03-19" version="1">MGITRKRVTDIDRIVAGRIELPVGFVSDSDVIETPICDQMKRVVRYRDSCVLSLDGTDTGTLWAGSRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR8</accession>
    <name>W4TJR8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminomethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68673">
        <property type="protein sequence ID" value="GAE68673"/>
        <property type="gene ID" value="JCM18909_1824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="406"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="512" mass="54362" checksum="4100D43A0EC2CCC5" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT2</accession>
    <name>W4TJT2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69046">
        <property type="protein sequence ID" value="GAE69046"/>
        <property type="gene ID" value="JCM18909_2228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9148" checksum="409679D4D001B0F2" modified="2014-03-19" version="1">MMTANNGETTGHYPTTTVNGEPYDPSGNETILDLVSARIGKTLRADGRTVDGSPLGIAVAVNGAVIRRAQWAATPVRGVIDVVTAVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ5</accession>
    <name>W4TJZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Seryl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69280">
        <property type="protein sequence ID" value="GAE69280"/>
        <property type="gene ID" value="JCM18909_2480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Seryl_tRNA_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="234" mass="25032" checksum="BFE1A89C58008B98" modified="2014-03-19" version="1">MIDPKLLRTDPDAVRRSQVARGEDPSVVDDVVAADEARREAIAAHENLRAEQKGLGKRIAKASGDEKAELLSRTKTISGEVADLKKAADEADAKFTELAKTLGNIVIDGVPAGGEDEGVIKETVGTPRDFAAEGFEPKDHLEIGEALGAIDMERGTKISGSRFYVLTGVGAQLEFALLNLAMSKAAQWGFTPMIPPALVKPSAMEALDSSVKLPMTFTTCLKMTSTLSEPPRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ8</accession>
    <name>W4TJZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein export cytoplasm protein SecA ATPase RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JCM18909_1577</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68439">
        <property type="protein sequence ID" value="GAE68439"/>
        <property type="gene ID" value="JCM18909_1577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="13">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="45"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE68439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="531" mass="60082" checksum="366C4C08EE14C08E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK13</accession>
    <name>W4TK13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68872">
        <property type="protein sequence ID" value="GAE68872"/>
        <property type="gene ID" value="JCM18909_2042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="249" mass="27329" checksum="BDED53ED30160D18" modified="2014-03-19" version="1">MTTGCHSGSTEPLYFELAWTAARPVPADLRTTVAAGGARRTIECKVTLLDSPDHRLLRSGIVVAHRVVDGLGEWYMDAPEWSPWLPVARSVALDAAGELPQDFTCLARPFLRGATLCPVAALSWERNETILEALDCTKLALIRDDRIAVVQSGVTTSRVRELTITPQRSLAEGQREWLTNRILALGGVPVSRHPSVLRRLGPGAGALTDYPRPHLHHGAGLQTWVSAQLAGQLRDVIELIWRFVARGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK28</accession>
    <name>W4TK28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69310">
        <property type="protein sequence ID" value="GAE69310"/>
        <property type="gene ID" value="JCM18909_2511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029324">
        <property type="entry name" value="AIF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14721">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIF_C" evidence="2">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="9808" checksum="3DA08CD93AF869BE" modified="2014-03-19" version="1">MGKAAGRIMAGSKDSYTHTPMMYSQVFGVRWEAVGTLDSSLATTSVEAGDGQVVYYLSDGKPVGVLLWNLPGRTDKAVTVLADPPEDLSTAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK52</accession>
    <name>W4TK52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68509">
        <property type="protein sequence ID" value="GAE68509"/>
        <property type="gene ID" value="JCM18909_1652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="92"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="249" mass="25905" checksum="9DA338BB49BD7D74" modified="2014-03-19" version="1">MASGANLRLSEHGYQMLLALVDSSRSAERVGSLIAGGSFDAAILVAMSNDDPLIARLMATNTPLVTASTPFPGFDIPSADTDNIGGSRAITARLVATGRSKLVAIGGPSWAPVTQLRLDGFHQGAKKNAALGHTTVNEWTLAAGKRAMKELLELHPDLDGVVAASDLLAAGATRALNEVGRRVPQDVGVVGFDDAPIAALNDPPLSTVRSDARAAGIALADMAIAQIRGQELPQPHLLLPNEVVWRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK66</accession>
    <name>W4TK66_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68529">
        <property type="protein sequence ID" value="GAE68529"/>
        <property type="gene ID" value="JCM18909_1674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5409" checksum="84C86C6E2179B30B" modified="2014-03-19" version="1">MIRTLVTKNAGSPQPSSRSGRKGFRGGTIVLAALLAAAVGGVSGGLVDRSLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK71</accession>
    <name>W4TK71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68539">
        <property type="protein sequence ID" value="GAE68539"/>
        <property type="gene ID" value="JCM18909_1685"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18560" checksum="DD3F0E3BE5840330" modified="2014-03-19" version="1">MPSATKKVSLVRRSEGHYTATNARGGQIRLGAGKDAEFTPVELLLAAIGGCSSIDVDTVTSRRGEPTQFTVSVSGTKHSDEEGRASLGDVAVDFQLSFPDTEEGREAAGLVNRGVTMSRDKKIAPSRGPSRPRLRWLSASPASRWTEVSWRVVLAAFFLRGVCSRRVFHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD8</accession>
    <name>W4TKD8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphate regulon sensor protein PhoR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68982">
        <property type="protein sequence ID" value="GAE68982"/>
        <property type="gene ID" value="JCM18909_2160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="47" mass="5188" checksum="E1410D7C2EE503C8" modified="2014-03-19" version="1">MSLVKHTCQAHGGSVDVWSKLGQGSTFTLRLPTLDVDHHNESNQEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKI6</accession>
    <name>W4TKI6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Proline iminopeptidase</fullName>
            <shortName evidence="4">PIP</shortName>
            <ecNumber evidence="4 6">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 6">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4 6"/>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="proac-q6a981">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69455">
        <property type="protein sequence ID" value="GAE69455"/>
        <property type="gene ID" value="JCM18909_2671"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PTHR43722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="47"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="335" mass="37786" checksum="50C074C47F807AE9" modified="2014-03-19" version="1">MTLATSELDITPQRDLYPPIEPYDTQMIDVGDGQQLYVEQCGNPDGKPVVFLHGGPGGGGGTERRRFFNPDAYRIIILDQRGCGLSTPHIAQAHTPREMATNTTWKLVEDLEKIRELLGIERWQVFGGSWGSCLSLAYAETHPERVTELVLRGIFTMREQELDWYYNFGASEVFPELWNKFCEPLRRVGHDFSRDNIAAYYDLLWDDDPDVHGPAAVAWTTWEGATTSLSFDPSHIEEFSDPNFALAFARIENHYFVNHGFMVEGQLLRDAHKLADIPTVIVQGRYDMCCPDVTAVDLSRALPSADLRIVMAGHSAFEPLIASELVKVCDEFAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL1</accession>
    <name>W4TKL1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-serine dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68948">
        <property type="protein sequence ID" value="GAE68948"/>
        <property type="gene ID" value="JCM18909_2124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849124" evidence="1">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11302" checksum="38523E18F8EF0C81" modified="2014-03-19" version="1">MACSMAAAGLAQVMGGTPAQVCNAAEIGLEHHLGLTCDPVGGLVQIPCIERNALGAIKAVTAARLAMAGDGSQIVSLDQVMKTMMETGRDMKVKYKETARGGLAVNIVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM2</accession>
    <name>W4TKM2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Osmosensitive K+ channel histidine kinase KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69341">
        <property type="protein sequence ID" value="GAE69341"/>
        <property type="gene ID" value="JCM18909_2547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="260" mass="27334" checksum="C4A04E5AED37F97B" modified="2014-03-19" version="1">MSVIAAQLGTALEQRQLEETAKAVEPLAATDRVRTALLSAVGHDLRRPLAAATAAVSGLRSEWSKLSDQDRADLLETADEALSQLANLVTDLLDVSRLQSGVLGVSVMPVDPAEVIMPALDELSLGPADVEIDLGSDVPEMVADPALLQRVVVNLLSNALRYEPAGSRVRLAESSFANQVEIRVIDHGPGIPEDRRDDVMVPFQRLGDTDSSVGLGLGLALSKGFVEGMDGTLALEDTPGGGLTMVISLPRVGVEEASAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS0</accession>
    <name>W4TKS0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">JCM18909_2316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TKS0"/>
    <dbReference type="EnsemblBacteria" id="GAE69127">
        <property type="protein sequence ID" value="GAE69127"/>
        <property type="gene ID" value="JCM18909_2316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11728" checksum="41F9D1D9743FDFF3" modified="2014-03-19" version="1">MAGQKIRIRLRAYDHEVIDSSARKIVDTVTRTGAKVAGPVPLPTEKNVFCVIRSPHKYKDSREHFEMRTHKRLIDILEPTPKTVDSLMRLDLPAGVDIEIKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS3</accession>
    <name>W4TKS3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S41B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69381">
        <property type="protein sequence ID" value="GAE69381"/>
        <property type="gene ID" value="JCM18909_2590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012393">
        <property type="entry name" value="Tricorn_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43253">
        <property type="entry name" value="PTHR43253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9408" checksum="383CD78A47DD8E3A" modified="2014-03-19" version="1">MGIDGRFDLVDGTSVTQPRYAGWYGSYGWGVENHGVDPDIVVTVSPEDWEADRDVQLDAAIAECLRQLDDKPAATAPELPGPAFGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ7</accession>
    <name>W4TKZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69640">
        <property type="protein sequence ID" value="GAE69640"/>
        <property type="gene ID" value="JCM18909_2881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6527" checksum="ED519EF30206781A" modified="2014-03-19" version="1">MIPTAADRLGAGLNMLEAVERSDSNSPLVGEVKSLLEDRDFAEARCSSRYLDWRSRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL06</accession>
    <name>W4TL06_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ORF">JCM18909_2317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69128">
        <property type="protein sequence ID" value="GAE69128"/>
        <property type="gene ID" value="JCM18909_2317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="23494" checksum="3D49FF4553F989A1" modified="2014-03-19" version="1">MTNEHTVKGVLGTKLGMTQLWDEHNRLVPVTVIQAGPCVVTQVRTPETDGYSAVQLGYGAVKAKNVTKPEAGHFEKAGVTPRRHLVELRTADASEYTLGQEIAADVFSESDFVDVTGTSKGKGTAGVMKRHGFGGLRATHGVHRKHRSPGSIGGCSTPGKVIKGLRMAGRMGVERVTVQNLQVHSVDAERGIMLVRGAVPGPKGSLLVVRSAAKKAAKNGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL47</accession>
    <name>W4TL47_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69257">
        <property type="protein sequence ID" value="GAE69257"/>
        <property type="gene ID" value="JCM18909_2453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8842" checksum="58779D47C2B9D8DC" modified="2014-03-19" version="1">MVTLWTVPGEIAHQFSERIRRQVIELHDQTARAYGMPTLDEYGRHRALSQASESGDTAPTSHSASTNKEPAELPRPNGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL67</accession>
    <name>W4TL67_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69715">
        <property type="protein sequence ID" value="GAE69715"/>
        <property type="gene ID" value="JCM18909_2964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="9858" checksum="4D72414E3A8DC2DE" modified="2014-03-19" version="1">MSSSFEEKGNEEATAVADAGMGVGVEDADVAMGDGVGVTGFAGSVVTRRATMTSATTSAVTMMTAIQPPWRFGGRYWLMSGGWFMVALLYVVAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA0</accession>
    <name>W4TLA0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69218">
        <property type="protein sequence ID" value="GAE69218"/>
        <property type="gene ID" value="JCM18909_2412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010860">
        <property type="entry name" value="CAMP_factor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07373">
        <property type="entry name" value="CAMP_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="323" mass="35554" checksum="2BF123CE74825319" modified="2014-03-19" version="1">MEFLGIYDDVFSEQQQAFAFSKLSLIRDDRRVRSRGQFVEKRGELYEDQIHSGPVGCRCLMVPATLSTPAAQAAVPTIPAVSSNTADAHKLLEDVNGRITSLNDDLKVAKASLSPMEVIDTIADLLKQAKQLKAQLEKIVKGVVTFATSIPARVELFLAMCDTTHTATLTLQDKVQNAHSTVFLAIAHAINVLITINSTPAQLTDEVAALKKAIAAAQAMPDLKPTDVATKYVRAKLGRVMVQVRFDRNTCVINYKDRDTVRLLNRAIIRAGQVRSNAWVRVADVDQAIKELKAAYQDALKAPNKKRAPRLHRPPVCRPLTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM2</accession>
    <name>W4TLM2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69646">
        <property type="protein sequence ID" value="GAE69646"/>
        <property type="gene ID" value="JCM18909_2890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="69"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="329" mass="35103" checksum="5043ACCAFB5B30A7" modified="2014-03-19" version="1">MTDITTEDRPAGLAGVPLAIEPLKRRDFASDQEVRWCPGCGDYAILSTFQGVLPDLGIAKENAVVISGIGCSSRFPYYMNTYGMHSVHGRAPAIATGVAVSRPDLAVFVITGDGDALSIGGNHLIHAMRRNVNLTILMFNNRIYGLTKGQYSPTSEAGKVTKSSPMGSIDAPFNPLAVALGAGCSFVARAVDSDRKHLAQVLTAAAKHRGTSFVEMYQNCPIFNDGAFDDYKGPEAAQHLIRLVDGQPVLVGADGSRGVVRDPVSGELTVADVAEVGMDHVLVHDSHRTDPSLAFELAHLDDGTIVTQTPVGVFRDVDLPTYDDQARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM5</accession>
    <name>W4TLM5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_2537</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69333">
        <property type="protein sequence ID" value="GAE69333"/>
        <property type="gene ID" value="JCM18909_2537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="88"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="367"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE69333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="785" mass="85399" checksum="5984599C59F131CF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR8</accession>
    <name>W4TLR8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69452">
        <property type="protein sequence ID" value="GAE69452"/>
        <property type="gene ID" value="JCM18909_2668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12787" checksum="541A022F1741B820" modified="2014-03-19" version="1">MCAALETEVPDDAELDLFESLRGAEGTEVVTQADLCPGNVLVTEDHARFVDYEATSIHHPAVDVVNLVMPWSSCDGLVGVPAEFLDAVHEGFLDGSRYAGSWLADEPMIGLAGQLQHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW6</accession>
    <name>W4TLW6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="17" type="ORF">JCM18909_3233</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69960">
        <property type="protein sequence ID" value="GAE69960"/>
        <property type="gene ID" value="JCM18909_3233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GAE69960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19747" checksum="A68EF46A224A281E" modified="2014-03-19" version="1">MNILEMNLGPLAPEHPIEIIVGVILVLLLTWLIAKAVVPRFEKLYEERTETIQGGIERAEKAQAEAKAALEKYQAQLASARDEAAQIRDDAKSQGAQIIAEMRANAQEEADRITERANAQIQAERDQAVREVRAEIGGLATTLPVGSWGSPCKMTSASRRPSTASSHRSPTSPRRLIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM28</accession>
    <name>W4TM28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69249">
        <property type="protein sequence ID" value="GAE69249"/>
        <property type="gene ID" value="JCM18909_2445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9257" checksum="491D7CBBF55FB06F" modified="2014-03-19" version="1">MHLRRLKRIEGQVRGLERMVDEEKYCIDILTQVSAVTSALKSVSLELLAEHMSHCVARAAQAGGQEAEDKIAEANQAIARLVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM59</accession>
    <name>W4TM59_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69617">
        <property type="protein sequence ID" value="GAE69617"/>
        <property type="gene ID" value="JCM18909_2855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13230" checksum="B268FF02F7B1D970" modified="2014-03-19" version="1">MTYSADLVPGTVTLVGGGPGDPGLLTVAGLEAVRQADVILYDRLAPAAVMDGNPQAERIPVGKVPRGPYVPQERTNELLIEHAKAGRKVVRLKGGDSFVFLAAVARSGRPALLLAFRCASSPASLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML4</accession>
    <name>W4TML4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69414">
        <property type="protein sequence ID" value="GAE69414"/>
        <property type="gene ID" value="JCM18909_2624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12245" checksum="E364ECB05079553B" modified="2014-03-19" version="1">MRSADPTLAPTNPTFFSRKRDTALSAPVAAPGKGHNVTIENDVESHLHPTPSWEIADHPMPTGARRFGGSPRLRPSHRFCPRSPLSHVRRPASSTSTSRGLTASPSSTWPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ4</accession>
    <name>W4TMQ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WhiB-like transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69991">
        <property type="protein sequence ID" value="GAE69991"/>
        <property type="gene ID" value="JCM18909_3267"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4327" checksum="3479CC5BC657B0B8" modified="2014-03-19" version="1">MAWALEAGQDHGVWGGMSEDERRAIKRRQSRSRVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN65</accession>
    <name>W4TN65_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">JCM18909_3235</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69962">
        <property type="protein sequence ID" value="GAE69962"/>
        <property type="gene ID" value="JCM18909_3235"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="PTHR11410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE69962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="29345" checksum="7E2B42FBF93D2900" modified="2014-03-19" version="1">MSGIVSPLEFHTPGLEDFKFGGTFGVAWMDKPFWQAIIAFLVVIAFWVWMSRGLKVVPGKRQVFGEYCYNFIRNSLVRDTIGHGFEPWLPYLVALFSFILINNWFGELFVFMFPTFSHAGYVYGLTIVSWFVYVIAGFKTKGIRYLKDSMLPPGVPWYLWWLIIPLEFLSNFITRPLTLSLRLFANMFAGHLIIMIFVVGGGFLLTYPSNIMYNAAGGLSMILSFALFALELFVGFLQAYVFTVLSAQYVASSISEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN66</accession>
    <name>W4TN66_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69654">
        <property type="protein sequence ID" value="GAE69654"/>
        <property type="gene ID" value="JCM18909_2899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="24173" checksum="F4429C0DD69C6E9B" modified="2014-03-19" version="1">MKQPVGRRRRIKWLAYVRAWRSWSVLEGLVGTILITTGSLTPAYLPLNSPWWSRLNEAGLRGSTWRIVGTLLVLVGVGLLVDSWLRLRPGREPRDLTAEPLPKHARRYFKHLPGIRAGLHPWAVLGVWGLPFLLAPPIFSHDAYSYAAQGWLLENGISPYEGYPGLLPGAFADQVAQEWRYTKTPYGPLASSSNMGSSTSLGTIPTGRRSLCVFRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNE5</accession>
    <name>W4TNE5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69908">
        <property type="protein sequence ID" value="GAE69908"/>
        <property type="gene ID" value="JCM18909_3174"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="280"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="606" mass="66100" checksum="F68376ABCCA560F7" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI2</accession>
    <name>W4TNI2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major myo-inositol transporter IolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69769">
        <property type="protein sequence ID" value="GAE69769"/>
        <property type="gene ID" value="JCM18909_3020"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="16868" checksum="C12E12BD427A47B3" modified="2014-03-19" version="1">MTSRIEVAELVVTTQPAGPKRRMGVVAAVATLGSLLFGYDTGVISGALPFMYLPHGAGGLALTVGHEGAIGGTLTLGAAFGGLIGGMMSDRWGRRHNLLTLAVLFVVGALGTAGAPSVWVMYPSEWCSDSPWERPQRQCRSTCRRPHPSGCVGGSWRLTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK0</accession>
    <name>W4TNK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70117">
        <property type="protein sequence ID" value="GAE70117"/>
        <property type="gene ID" value="JCM18909_3408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14338" checksum="DCC45841B77206E4" modified="2014-03-19" version="1">MSVPTITLNDGVPIPQLGFGTWKVPANEAEKAVSAALEAGFRHIDTAAIYGNEEGVGRALADSGLDRKDLFVTTKLWNDSHHADDARKAIETSLAKLGLDHVDLYLIHWPAPVKYGDATSRRGTPCKTSSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN9</accession>
    <name>W4TNN9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69824">
        <property type="protein sequence ID" value="GAE69824"/>
        <property type="gene ID" value="JCM18909_3080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7928" checksum="9D611C803DFEECFF" modified="2014-03-19" version="1">MAESTVVLAAICGALLACAPVFVISGRRNAPLRLSDAWRDCPIMDVRTPSSISPRRADGWSGGEREQQSAGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR8</accession>
    <name>W4TNR8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="5">4.1.2.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Queuosine biosynthesis protein QueD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_3326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.50" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70043">
        <property type="protein sequence ID" value="GAE70043"/>
        <property type="gene ID" value="JCM18909_3326"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE70043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9600" checksum="F151A9BBF41C9270" modified="2014-03-19" version="1">MELISDTLNAIGFVVDYRDLSPIKDWLNKELDHRCLNEVIAANPTAENLAMHIAKIIRKVTNIPREVHVAVGVSETAKTWARYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU0</accession>
    <name>W4TNU0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70207">
        <property type="protein sequence ID" value="GAE70207"/>
        <property type="gene ID" value="JCM18909_3505"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="7">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9426" checksum="814DF3EF7721100B" modified="2014-03-19" version="1">MELIGIQDGFLGLAGNRTISLGPRALSGILTVGGTILGTSRDKVNHMIIDGEERDMVPTIVENYEKLGLDALVTLGGGGTAKNAYKLAKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU1</accession>
    <name>W4TNU1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligopeptide transport system ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70391">
        <property type="protein sequence ID" value="GAE70391"/>
        <property type="gene ID" value="JCM18909_3709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8356" checksum="368F031B6388EEEE" modified="2014-03-19" version="1">MRAQILNLFDDLQDSLGLGLVFISHDMNTVRHISDRIAVMNAGKVLELASVEEISEHPQDPYTKKLLGAVPSLLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU5</accession>
    <name>W4TNU5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Large secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70212">
        <property type="protein sequence ID" value="GAE70212"/>
        <property type="gene ID" value="JCM18909_3510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9838" checksum="B94F33D4FF9D4748" modified="2014-03-19" version="1">MLLQSHDGRIRLLPALPPAWEAEGEAIGLRARGGYRISMQWRDGWVTWFEIVADRGHTEDVIVVVNGREQRIRPDKRRPWSRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX5</accession>
    <name>W4TNX5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70113">
        <property type="protein sequence ID" value="GAE70113"/>
        <property type="gene ID" value="JCM18909_3404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="8"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="341" mass="36613" checksum="D2A60095A860DBB9" modified="2014-03-19" version="1">MLALTLGDDARSLHLVTVQAPEATRPDDVIVRILQSGICGTDRSVLVGKFDARPGVIMGHEAVGIVEGTGDWVTNVKPGDRVVVNPTLFCGECLECRKGRFNHCVNKANNEIGIDRDGTFCEQIVLPAQFVVPVPDEISTDRATLIEPFCCALSNVTAAGVQPGSRVIILGGGPVGALASIAAALSGGQVTLVEANPHRRVLLQGVFDHPDMPTVSILEANRPPESQPRADVVIDTVGNLLETAVSLLAPKGTAVVMGYNSSAEARLRPIDILFGEYRIIGAGDYNYPMFQRAFDTGIRIPLERIITHKFGLSEYKQAFGFLSVNQENAYDALKVVLESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNZ3</accession>
    <name>W4TNZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70133">
        <property type="protein sequence ID" value="GAE70133"/>
        <property type="gene ID" value="JCM18909_3429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19611" checksum="EE1507ABA535558C" modified="2014-03-19" version="1">MSSTNHITRQPVPPTNNVRVNAAVAAPEAADAATDRRVDTTFDKFHDRYSTRSLGLKTSPVRALFAVANRPEVVSLAGGMPNIADLPLDVVSESLKGLVDTRGTVVMQYGSGQGEPEMREHICEVMAVEGLVADPDDVTVTCGSQQGLDLVTRIFLQPRRRHYGRVAGLCRGAQYLRLVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP01</accession>
    <name>W4TP01_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type III restriction-modification system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000082">
        <property type="protein sequence ID" value="GAE70715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70715">
        <property type="protein sequence ID" value="GAE70715"/>
        <property type="gene ID" value="JCM18909_4099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7978" checksum="83CF4ED3FF151260" modified="2014-03-19" version="1">MRDRLHHMKKLLADDGSIWVHLDYAENHRMRLLLDESSVAQTSLPSSCGRKQTRREVTLNVFRWIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP11</accession>
    <name>W4TP11_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70446">
        <property type="protein sequence ID" value="GAE70446"/>
        <property type="gene ID" value="JCM18909_3771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11053" checksum="80CFF5140B4E2874" modified="2014-03-19" version="1">MKTLLRPLPPRRGVMLWMGPLSASRGSSYQMTAPTRYLAIRKKAAAFVAAHPKHQEVRVVAGALRDGSHYGVARLVEHPDELLGSIDLVPALESAVLETLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPE6</accession>
    <name>W4TPE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70283">
        <property type="protein sequence ID" value="GAE70283"/>
        <property type="gene ID" value="JCM18909_3590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="15412" checksum="4BAEA746083FE605" modified="2014-03-19" version="1">MIPREHRAAILDAAKRGWVALVAYVRAAVIVAFVDGLGAGIGAAIIGSSMSVAIGALTFILAFVPIVGALTAGVVAVGVVLVTLGFFKAFIMLIVFVAVMQIEDTSCSPSYWARPSPFIRSSCCSVLPSVPSSLASWALCSPFRSLPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPH4</accession>
    <name>W4TPH4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70631">
        <property type="protein sequence ID" value="GAE70631"/>
        <property type="gene ID" value="JCM18909_3989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="7">
        <location>
            <begin position="31"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13001" checksum="A423F2B0361D9418" modified="2014-03-19" version="1">MRHMDSATQATTPTEGSTEEPQLQRGLKNRHLQLIAIGGAIGTGLFLGSGKTISLAGPSILLVYLIIGAVLFFVMRAMGGATAVEPGLQVLRRLRDRPRWPRRRVLHGVDILDVLGRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPP4</accession>
    <name>W4TPP4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70194">
        <property type="protein sequence ID" value="GAE70194"/>
        <property type="gene ID" value="JCM18909_3492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8262" checksum="694FC64BF9ACCBAC" modified="2014-03-19" version="1">MLIDPTTSIDAVTTATIARKVRQLRAGRTTIIATTSPALLDQMDEVVLLDAGGRQIARAPHRELLARDDYREMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPP6</accession>
    <name>W4TPP6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000076">
        <property type="protein sequence ID" value="GAE70711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70711">
        <property type="protein sequence ID" value="GAE70711"/>
        <property type="gene ID" value="JCM18909_4094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="6849" checksum="FD827E56DC04DC5E" modified="2014-03-19" version="1">MAVSAFGSSGIADEAMFFNLRSLAIDPAMLLFNFSDIDVAVANRIATRLPSAGILLTVDLTCAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPW4</accession>
    <name>W4TPW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible oxidoreductase of the aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70274">
        <property type="protein sequence ID" value="GAE70274"/>
        <property type="gene ID" value="JCM18909_3581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13381" checksum="F4129A862056AB70" modified="2014-03-19" version="1">MARTAGISNANPDQIRLAHSILGDRLVAVQNQFSPGFLSSRPELELCGELGLAFVAWSPLGGYRRPLDEDAFAAFQRIADARGISRAQVILAWELSQARTSSRFPGLTVPRRFLTPSGPSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPX4</accession>
    <name>W4TPX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exodeoxyribonuclease V gamma chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70587">
        <property type="protein sequence ID" value="GAE70587"/>
        <property type="gene ID" value="JCM18909_3937"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9153" checksum="82CF5E6E51D7FE98" modified="2014-03-19" version="1">MAHNDYRTGTSALQVQWSRERDPNWAAFFLGTDVGELITCCHELGTTLKELSGWLFDPIKQALRGAGSSQSTMAQFSNSGRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPX5</accession>
    <name>W4TPX5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidinol-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70428">
        <property type="protein sequence ID" value="GAE70428"/>
        <property type="gene ID" value="JCM18909_3746"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7027" checksum="8780564A1237ECB5" modified="2014-03-19" version="1">MMVAEGVVDVACEPELSLHDMAALDAIVTEAGGKFTGLDGKDGPWSGNALASNGFLHDQALAMVQPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ71</accession>
    <name>W4TQ71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-proline glycine betaine ABC transport system permease protein ProV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70374">
        <property type="protein sequence ID" value="GAE70374"/>
        <property type="gene ID" value="JCM18909_3690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="278" mass="30620" checksum="0729D88C448F12E9" modified="2014-03-19" version="1">MIRFDHVSKRFDDGTVAVDNFELTVESHHLVVLLGSSGCGKTTLLRMVNRMVDPSEGRILIDDTDVATINPVKLRRQIGYVMQSGGLLPHRTVVDNIAAVPLLSGVSRTAAHTRAMDLLERVGFDSSLARRYPTQLSGGQRQRVGVARALAANPDILLMDEPFGAVDPVVRTELQQGLLQIQADLAKTIVFVTHDVDEAFLLGDEVLVLRREAQVAQRGRPDDILLHPIDDFVSSFIGGDRRNLHMERHDDHPTIVDAGGRLVGRFANQPSTTVRENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQG5</accession>
    <name>W4TQG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70469">
        <property type="protein sequence ID" value="GAE70469"/>
        <property type="gene ID" value="JCM18909_3796"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="13520" checksum="3ACE409653B95D9C" modified="2014-03-19" version="1">MTVTMRIAATLLVIAAVWGGKYVVSLIFRAAGVRAGGNTGLLRGGLWIGYLERLGIVTAILTSYPAGIAVILGVKTLARYAELKSQPTPGSDAAQANKESSAAIEQFIIGTMASALWSVLLTVTAKALWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQJ2</accession>
    <name>W4TQJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70499">
        <property type="protein sequence ID" value="GAE70499"/>
        <property type="gene ID" value="JCM18909_3826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="272" mass="29586" checksum="A2059A391DD1A759" modified="2014-03-19" version="1">MAGTLAEMKSIGIPAIFPGVSTDRVHVTLVEMANHLLMPFDPALRHYTRRQLQKRGVDVRTSTAIAEVREDSVLLKDGQTLPADMVIWAAGVGAHKSVTNWGFEQGRGGRIATNGTLLVKGQDRIFAVGDGAINTEDPKPQLAQPAIQGGECVARQIVHLELGEPLEKFEYNDKGTMATIGRNSAVVQLSEKLKFTGIGAWLTWVTVHIFTLLGGRNRLQAMINLGARYIAFHREAGAIVGDVLSEEGKENINKNALRDDDEKGTKPIDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDN8</accession>
    <name>W4TDN8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7 8">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recA</name>
        <name evidence="12" type="ORF">JCM18909_100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67065">
        <property type="protein sequence ID" value="GAE67065"/>
        <property type="gene ID" value="JCM18909_100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="174"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="321" mass="34276" checksum="A7671BE31D868B26" modified="2014-03-19" version="1">MRLGEQETVKIAAIPTGSVALDVALGVGGLPRGRIVEIYGPESSGKTTVALHAIANAQAEGGICAFIDAEHALDPEYARKLGVDTDSLLVSQPDNGEQALEIADTLVRSGALELIVVDSVAALTPKAEIEGEMGDSHVGLQARLMSQALRKMTGALNAAGTTAIFINQLREKIGVMFGSPETTTGGRALKFYSSVRLDVRRVETLKDGSEMVGNRTRVKVAKNKVAPPFKQAEFDILYGQGISREGSLIDMGVDCGIITKSGSWFSYNNEQLGQGKENVRKFLKGNPDVANEIEDKILTHLGLREAEVPEGVDPRTGEVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDX8</accession>
    <name>W4TDX8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Site-specific DNA-methyltransferase (cytosine-N(4)-specific)</fullName>
            <ecNumber evidence="3">2.1.1.113</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.113" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67165">
        <property type="protein sequence ID" value="GAE67165"/>
        <property type="gene ID" value="JCM18909_207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="401" mass="44569" checksum="968142F7D95C95DD" modified="2014-03-19" version="1">MPERTSRRSAHWCKDNPPVPGENGTRHRHRPSTPAANDAGVVVLDPMCGSGTVLAAAAERGHTARGFDVDPLAVLMSSVATQAVDTELVVSEAERVCTRARASRVDKPRWSDPETRKFAEYWFAPKQRGQLNRLSRELDRVADDSIRQALQVALSRIIVTKAPKASLAADTSHSRPHRVATESSYDVYRGFISSAIALKKLLDQRSLVGQVQVRRGDARALDLPDSSVDLTITSPPYLNAIDYLRGHKMSLIWLGHTIPELRSIRSNSIGAERALHGEILDQVESMLRYIKESATDPDQLPLATISRYAHDLTQFSRELGRVCKPGAKVATVIGNSTLRGNYIQNDMLVRLSYENSGFRVVDRSERVLPENRRYLPVKTADDASSMAKRMRTEVVLTVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE60</accession>
    <name>W4TE60_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67066">
        <property type="protein sequence ID" value="GAE67066"/>
        <property type="gene ID" value="JCM18909_101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14748" checksum="0EE37AB4F720038A" modified="2014-03-19" version="1">MPEPVREAVLDRLTEVGLIDDADFANRWTASRHGMRGLSRRAVAAELSRKGVDSHIIEDATSQITDADELDAATELAITKLRAGYGIEEARLTRRVLGTLARRGYGPHIAWAAIRAARDELGEEPPEAPTTGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TED7</accession>
    <name>W4TED7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67330">
        <property type="protein sequence ID" value="GAE67330"/>
        <property type="gene ID" value="JCM18909_377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8957" checksum="587281A22C5C3878" modified="2014-03-19" version="1">MDKENYSPVINSYAAMWEEYREVTNPLAVLGVCQRILNHYFLHTAGRDPSSLRDIILGAHRHLFITKKTLTERRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEH5</accession>
    <name>W4TEH5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="11" type="ORF">JCM18909_420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67370">
        <property type="protein sequence ID" value="GAE67370"/>
        <property type="gene ID" value="JCM18909_420"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="315"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="398" mass="41882" checksum="E763FD87300460AF" modified="2014-03-19" version="1">MLRYLTAGESHGPALVATMEGIPAHVQVGAVEISEELRRRRLGAGRGARMSFEADELELLAGFRHGETLGDPIAIRIGNSEWEKWRTVMAPGPVAPEDLAGHARAAALTRPRPGHADLAGMQKYDFNEARPILERASARETAARVALGAIAKAFLKQSLGVEVLSHVVSLGPVAAPNGLRPGPSDLTRIDADPVRCADSVTSKRMVAEIEACRKECDTLGGVVEVLAYGLPAGLGSHSQGDRRLDARLAGALMGIQAIKGVELGDGFDLARRRGSQAHDWMEPTEGGIHRVSDRAGGTEGGMSTGQILRVRAAMKPIATVPRALPTVDVTTGEAAKAHHQRSDVCAVPAAGVVAEAMVALVLAECALEKFGGDSVTETRRNAQAYLDRLAARGLAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEK7</accession>
    <name>W4TEK7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67226">
        <property type="protein sequence ID" value="GAE67226"/>
        <property type="gene ID" value="JCM18909_271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="5">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="3">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="270" mass="29118" checksum="B88DA7387AE85636" modified="2014-03-19" version="1">MSSPASQIVDAVGGPDNIVGLTHCATRLRFQLRDSSPIDKAEVEAIPGVMGAVPQSGNRYQIVIGGAVAGVYNDIMGLPAMKGLSSGSGNQSDADVKAEHRSKGPRGKFSWLDNLFEYLSDSFRPIMGALLGASLFITFMALMGSLGVIGNWADSRVTLPPSWQFVNLAWQCVFYFLPLLVAYNATKRLNADPWVGFSVMAVVMLPAFTELGKTAHPLTLGGFKVNVVDVFGLPLTIFNYGSQVFPPLIMLQSWPRCTNGSRRSSPPMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TER0</accession>
    <name>W4TER0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67435">
        <property type="protein sequence ID" value="GAE67435"/>
        <property type="gene ID" value="JCM18909_496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24116" checksum="4D00D800F5F42896" modified="2014-03-19" version="1">MVILLLWMPSLPMRFMNTTMVITYVLEREHHMHRRLLAIATLSACALAMAGCSNSGPDSGSGPSASSDKVDVVASTNVWGSVAQAIGGDKVNVHSIINSPDQDPHDYEATAKDKLAFSKAKIAIANGGGYDDWATKLIKSTSPQAGFIDAVETSGLKKPGQKEFNEHVFYSIDSVRKVAKVVESDLVKASPDNKTTFETNLKNFESKLTDLKARATKVGKKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF77</accession>
    <name>W4TF77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67411">
        <property type="protein sequence ID" value="GAE67411"/>
        <property type="gene ID" value="JCM18909_469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="23887" checksum="BD1215F72A2EA4CF" modified="2014-03-19" version="1">MSSRCSSSWQASSTIYWVVFGHSWGSMIARAMATRPGTRLDGLALCGIVAQPRGFETTLDHKALAKAMATAPTDPAPEALVAQMFDGFADRLSEDDGPTGWVARNKEVVADHGKDKFNNFGAPMSTRFLQGLADIYSMANGEGFYAAMPKIPIALFAGSEDPAGNFGTGVQAVAQRLRGDGHNVELHLYDGLRHEVHNEPESRADVESSLVTFVDRVVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF95</accession>
    <name>W4TF95_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein co-occurring with transport systems</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67202">
        <property type="protein sequence ID" value="GAE67202"/>
        <property type="gene ID" value="JCM18909_245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="18892" checksum="34C74F38E0072A43" modified="2014-03-19" version="1">MIEYSVLAGPVETELEIKRSVFLTRLVRVTCEDEAREVIAQARHDGHNARHHVSAFVLGTDRGVQRCNDDGEPAGTAGMPTLAALTAADPRGNPDLSDIVAVTSRWFGGIKLGTGGLTRAYGNAVGNALTVAAFHRRVMMDIFTTTIGLRRAGHEEGVIRAAGHDVTNVEYTAKGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF99</accession>
    <name>W4TF99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67108">
        <property type="protein sequence ID" value="GAE67108"/>
        <property type="gene ID" value="JCM18909_146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="329" mass="36454" checksum="5F4413F51EA070F1" modified="2014-03-19" version="1">MGAGTHEDYSSPAEAMHYHRYSYDTGRFISEFGIHASADLPTLGRWLGDGHLNLDDPILLARNKDTPKAKGVALIDYEVGKPTSVQSYVTYSQVVQAEGLKFGIEHYRRRWPHCAGALVWQLNEPWPGMTWSLLDHDLGAKPGYYATARAFAPALSILRLTDDSLEVWVSNARPTRVTDTVTVTIEGFDGSIDQTHRVKVSVPASTSQMVWSVPRTQIPVNGSHYIWVEGSVLPANRLFLTRIGDLNLPEAHLDVKVDVTELTTATVTVATTTFAYFVRVLTPWPSARPDISALDLRPGTKAVVTVTGLPEGFDPDEIMVRHFLDDVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFP8</accession>
    <name>W4TFP8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67601">
        <property type="protein sequence ID" value="GAE67601"/>
        <property type="gene ID" value="JCM18909_674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17142" checksum="0496CAC45C55D29E" modified="2014-03-19" version="1">MSSRPPDPKKVDLIGWSQGGGPLPNYYITKLGGDKKGQQAHRPCPVESRRRTPSVSRFVNESISEARHKKIEATFAKAHIASYEQQLGFSNFNKELYGNGPVTRPGVKYTVIEGRYDDVVVPFTNAFLNEPGVKKTSSFRTPAATITPATSTSPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV1</accession>
    <name>W4TFV1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="11" type="ORF">JCM18909_940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67850">
        <property type="protein sequence ID" value="GAE67850"/>
        <property type="gene ID" value="JCM18909_940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="151"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="164"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="204"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="218"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="305" mass="32663" checksum="F2FB3EEC10A06374" modified="2014-03-19" version="1">MSTKDWADKDYYKILGVSKDAKPEEIKKAFRKIARDNHPDSHPGDKAAEARFKEASEANDVLSNTKKRKEYDQARSLFGSAGGFRFPRGGAQTSVNVEDFLRTASNGDGFGDLFGNLFGASGGRRTASRSPRRGADVEGETTISFDDAVSGTTVTMDMVSQTPCQACRGTGARAGTVPRVCSTCQGSGMHASSAGGVFEMTEPCPDCHGRGMIVEDPCQVCHGSGRAKSTKSMQIRIPAGVEDGQRIRIKGKGSPGENGGKAGDLYVKVAVRPHEIFGRDGHNLTVTVPVTFPEATLAPRWRCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY3</accession>
    <name>W4TFY3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">JCM18909_774</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67696">
        <property type="protein sequence ID" value="GAE67696"/>
        <property type="gene ID" value="JCM18909_774"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="124"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="287" mass="30238" checksum="BDD33CB1C5BF1F98" modified="2014-03-19" version="1">MTAQKLDGKATAAAIKSELAERVAVLRDQGVVPGLGTVLVGEDPASHQYVAGKHRDCAQVGIESIRVDLPADVAKEELAQKIRGLNANPHCTGYIVQLPLPRHIDTNWALNLIDPNKDADGLTPASLGRLVLNEPAPLPCTPRGIVELLTRHGIELPGANVCVVGRGTTVGRPLGLLLTRRSENCTVTLCHTGTRNLAEHTRQADIIIGAAGSPGLINADMIREGAVLVDVGVSRTAEGKIQGDFTADVWEKAAWVSPNPGGVGPMTRAMLLSNVVDRAERLAADPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG56</accession>
    <name>W4TG56_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67512">
        <property type="protein sequence ID" value="GAE67512"/>
        <property type="gene ID" value="JCM18909_576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP_3" evidence="1">
        <location>
            <begin position="176"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="300" mass="32075" checksum="240E42AB94A7F501" modified="2014-03-19" version="1">MQPDTPSLVEVTIMAARAERSVKRLATTWVATARCLLPQPNTDPLGPGEAQLWGRHHIAHLMVIFTDTLQTVTTPTTIRPMTLARVIDERRKATDTLAAIGHEVIADDTASRLASQAQRLLDNVESVLLATPGPPATVDSLVGPVRVTDQLRATLLAMTAMGLHDGIDIPSGAIIESCRTLSAVLDETHGGRTIELRVPPACAVQLAAIESGPNHHRGTPPNVAETDPVTFLQLATGFSHWPEMRSAGRVQASGSHVDDVAGMFPVVDMAGVFRDIFCRRLDASSNLFRGVAGNDQARTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG57</accession>
    <name>W4TG57_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67776">
        <property type="protein sequence ID" value="GAE67776"/>
        <property type="gene ID" value="JCM18909_859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="23520" checksum="74128D1047B17F0C" modified="2014-03-19" version="1">MRGVATFLKGRHAIALVIAPLVALLVAFFLWKASLSVAPGDVWDRPVTGPELIILVGCATIMWCVSSAMDWVERTSVRSLTVGYAWMGLWICGCAAGLPLLIGWVLRSLPVELIPDGDSVLVPQIPARFQLPWPPFIGFSVTCVLCTGIALFVTGMVSRRVGPLCGPLIYLVVVVAQSNTLLRFLPGGYPGKKRPPSRGVRRQCLPRPWCVPSFVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG72</accession>
    <name>W4TG72_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TetR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67791">
        <property type="protein sequence ID" value="GAE67791"/>
        <property type="gene ID" value="JCM18909_874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23156" checksum="D7DBE61095BB607C" modified="2014-03-19" version="1">MRKRPGRKPAFTRRQVIDATLAEGIGSFTLRAVAERLGVKATALYREFSSRQELQLAAISAIAADIEPDPQLCTWQDVLRDVVDRQWQMCVRYSEAAAVIVTRPEAFGVALPRITAIVERLAALGIPGGKEGAAFALDFAGDTALETYMSVQPYMTCDEEGRTGLDKFVRIAGELPELFGMQDMGERGNLDLKIEFIIAGMEHGLFPGVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG87</accession>
    <name>W4TG87_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oligopeptide ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67806">
        <property type="protein sequence ID" value="GAE67806"/>
        <property type="gene ID" value="JCM18909_891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17779" checksum="8B853DB8875CE8EB" modified="2014-03-19" version="1">MISQSGFTSTTHMFAELKSSFFSNVGINLEIREVPDSVAESQACKPNDTNCTWDLSFFGSQSSWYYPVYASGERLFQSGGPVNLGSYSDKKADELIDASMRSNDRAALKTYNDYLAEDLPVLWMPNSVNRVSAWKSNIQGIDPQDPMLYLYPQDWTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA5</accession>
    <name>W4TGA5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67821">
        <property type="protein sequence ID" value="GAE67821"/>
        <property type="gene ID" value="JCM18909_907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="355" mass="39163" checksum="2ED2116C6C83C680" modified="2014-03-19" version="1">MPSKSIVFSYTFGAVESVFDVPGLCTYVEVRAKVLPSAARVLSAIWMQSSALDGGPSLLTGAEPNPELDVEETFDHTKMNIATHVWPDNTEATHRRFGGHAYPVGVDISRDYHTYGVERSDGRLRFYCDRHLAWETKPGDSSLWRMSRHMVLSLEGHLGTPVVSRLPASFDIDYVRAWYAPNPALESGDYRLTSADGRFLACHDGVPTLQAQPQTWCVVRHGDCTYSLSTPGGAVLGLDVEAGKHEVVVGSGLRTTSDAEGSLNRWHLLADGAGRTLHSKFTGLPIVVADSRVIEARIRPRQRSGRLPRRSPRLFLAHRRRRFPFRPPRSLHLSSRGCGPVAPGLPRTPLPRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC2</accession>
    <name>W4TGC2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67458">
        <property type="protein sequence ID" value="GAE67458"/>
        <property type="gene ID" value="JCM18909_519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14244" checksum="D7965120E1AE926B" modified="2014-03-19" version="1">MRSIAALMVVLAILAGLGWGGYKVWKPVDPFATTEPEGCRVVVLGQSYDLDLEQSQNAAIITAESIRRGLPTRAAAIALTTAMQESKLRNIDYGDRDSLGLFQQRPSQGGEPPSRSWIRGIRRENSTGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF1</accession>
    <name>W4TGF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">1,4-alpha-glucan (Glycogen) branching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67229">
        <property type="protein sequence ID" value="GAE67229"/>
        <property type="gene ID" value="JCM18909_274"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_48" evidence="7">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Aamy" evidence="6">
        <location>
            <begin position="183"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="389" mass="44428" checksum="927E4B6090F38972" modified="2014-03-19" version="1">MAHDEFGGLTGWDLEGFHSGGDTEVWKRLGSHVVTIDDDERGPITGTRFAVWAPNAQAVEVISDFNWWTGDCMRLIPGSGVWGTFVEGVDEGTLYKFRIQDQWGTWHEKVDPMARYSEQAPQNASIVTETHYEWNDDEWIARREASRAHAEPMSVYEVHLGGWRHGLSYRELADQLVSYVTWQGYTHVEFMPLAEHPFAPSWGYQVTGYFSPTSRYGSPDDLRYLIDKLHQASIGVIMDWVPGHFPKDDWALGRFDGTALYEHADPRQGEHKDWGTYIFNYGRNEVKSFLISSALYWISEFHVDGLRVDAVASMLYLDYSREEGEWVPNKYGGRENLEAIDFLRYVNSHLYSRHPGILMIAEESTSFPGVTKPVDDGGLGFGFKWNMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF5</accession>
    <name>W4TGF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67866">
        <property type="protein sequence ID" value="GAE67866"/>
        <property type="gene ID" value="JCM18909_957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12379" checksum="460F23F467B453F7" modified="2014-03-19" version="1">MSASVTAAPTTTSRTASAVRTLDLTKTYGSGTTLVRALRSVTLDIPAGRFTAIMGASGSGKSTLLHCITGLDSPTSGQVWIGDTEITHLDDDALTTLRRQHVVRVSIFQPHAHSQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH5</accession>
    <name>W4TGH5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_299</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67254">
        <property type="protein sequence ID" value="GAE67254"/>
        <property type="gene ID" value="JCM18909_299"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="9">
        <location>
            <begin position="12"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20506" checksum="C043E4807502EF13" modified="2014-03-19" version="1">MPPTVTGTVLDGIISGVLDDLHERQLMVTSDNLREAIELVAPAIDPIPRLTAPGLSVISEIKRSSPSNGQMAAIHDPAALADQYRSGGAAAISVLTEERRFQGSLADLDAVRAKVEIPVLRRDFVIAEYQVLEARAHGADLILLIVAALSDDDLQRLYDLAIELGMTSLVEVHTPEEVSRATALVPVWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ8</accession>
    <name>W4TGJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68085">
        <property type="protein sequence ID" value="GAE68085"/>
        <property type="gene ID" value="JCM18909_1198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850721" evidence="1">
        <location>
            <begin position="33"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="321" mass="34768" checksum="AF2276BFF3048B47" modified="2014-03-19" version="1">MTSMTRRGFATLSGLAMASIAAGCGRSSSPQAASTTGAKIKQGKATGNLTIWAMGAEEGRLPALLKKFTAQNPDCNITMTPIPWSSAHDKITSAIAGGTTPDLTQIGNTWMSEFVGLEAFDPAPSSIDMARFFEGSRKKSVFHGTTYGVPWYVETRCVFWRKDLAREAGITKAPQTWEEFKALARAYKKAGAKFGVSLPPGGQGSWQAYVPIMWSNGGKLMNNDEKTFTLDDPRNIEALSYYQSFFTEGLASTASSSAPAGAEFADGSVPMFISGPFMIDTIEKAGGGEKLKEKYGVFLIPKKSVIHLPSWWLQPRCFQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM8</accession>
    <name>W4TGM8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translocase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67309">
        <property type="protein sequence ID" value="GAE67309"/>
        <property type="gene ID" value="JCM18909_356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="15319" checksum="C0E69E47F4356D6A" modified="2014-03-19" version="1">MPLLASPLGGFMPLLIIFLSCSLVSRCGRASGRSKKQQEERAQLESRLEVDTRVVLSSGLFVTITHIGDKQAVVELAPGVEVSVLKQAIVRPAGDEEEFAFADDVPTENSTAHDDIATEPASDVLTSPEASAVNADTSDEQPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGQ4</accession>
    <name>W4TGQ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67334">
        <property type="protein sequence ID" value="GAE67334"/>
        <property type="gene ID" value="JCM18909_381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8182" checksum="C7070CEFDD13DC42" modified="2014-03-19" version="1">MNYSTSTSIPVPWSAEYTNPNKCFFLLRRHQAYGTGAEHTVTENQIIHLGEGNEALYGFTWNTEEERDKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH64</accession>
    <name>W4TH64_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68126">
        <property type="protein sequence ID" value="GAE68126"/>
        <property type="gene ID" value="JCM18909_1243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="128"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="290" mass="31050" checksum="3710125A97C7D541" modified="2014-03-19" version="1">MASQCGCESAIGQSAGAVGLVIARDDRSFAGEGFFLHLIAGMEEILTPARTALVLQLVASREEECEVHRHWWAQRRVDGVVLVDPARNDPRWPLMAEIKMPCTVVGAMSDTPLPGVHIDDAAAAGNIVTHLINQGHRRIAHIGGDPTLEHSMVRRRAFAQEAERLGAVVIEAAATDYSEQSGLRETSALLKTGDRPTAIVYDNEVLTLGGLAAVAEHRLQVPTDISVVSFEDSPACRVMSPGITALRRDPSVLGRDAITMLMGILGGDDVEDVTEQPPELIVRGSTGQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE1</accession>
    <name>W4THE1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68211">
        <property type="protein sequence ID" value="GAE68211"/>
        <property type="gene ID" value="JCM18909_1333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="170" mass="17244" checksum="2877B57519CD3687" modified="2014-03-19" version="1">MGMVFGSVQTGTTSLATDAGRPGLAGLFHALLSVGSAAAGLALPRLAHRLDLPARWRLFAAGLALFAAPLLLVDRLGPLVPVLIILGMAAAPYMITLFSVAERSALAGRIGTVMTLLAAMNSLGYAFGTTLAGRLADWGGATPAYAVTWGVGVAATLLALPAASRVAPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE3</accession>
    <name>W4THE3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport system secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67912">
        <property type="protein sequence ID" value="GAE67912"/>
        <property type="gene ID" value="JCM18909_1007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14362" checksum="C97CF0CF9467FE7C" modified="2014-03-19" version="1">MGPGNEFDRRGFMRLTGAIAMAAGLTVSLSACGGDNPNKKTSQGGSTSSGGVGNSDGTITAGISYELGTNGYDPMTTTAALTVAANWHTLEGLYEIEPTDPTKAYAALAADEKRERSTRRPTRSSCVRKLRSLTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF4</accession>
    <name>W4THF4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68390">
        <property type="protein sequence ID" value="GAE68390"/>
        <property type="gene ID" value="JCM18909_1525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsK" evidence="2">
        <location>
            <begin position="149"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="447" mass="47858" checksum="4FBFC804B515B4C4" modified="2014-03-19" version="1">MVDNLALTQGRDCPLRDILEYRPERSEQAAQRFVSAIIVVPNVDQLPSSCHTVIHAETDNEATVVIPSQAERTPHVTAAGIDADTAQDWARRLARYDDPSAATSGGGLPGLVHLFDILGFDRATMDASTIVSSWQRSTGPNVPLGVCDDGTFVFDLVADGPHGLVGGTTGSGKSELLRSLVAGLAARVDPQHLTFILIDFKGGAAFATLDQLLHTIGILSNLEPSLAFRALQALNAELKRRQQCFADAGEGIDNIDAYLATDPTEPMPRLLLVIDEFAQLAKEYPDVLSGLVSLGAVGRTLGVHMILATQRPDGVVNDDILANTNMRTALRVQSREQSSNVIGVPLAASIGREQKGRAYIKLGEEDITPIQTALVTGVSGARGSQDLHVDPMILGNAPEEHAIRANSAEVSDMDVLIRWIAEANEQLGYGPARRVWLSRCPIMSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THI0</accession>
    <name>W4THI0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DedA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67893">
        <property type="protein sequence ID" value="GAE67893"/>
        <property type="gene ID" value="JCM18909_985"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6485" checksum="C8810D683AF90836" modified="2014-03-19" version="1">MTLPALLTPTWMDPQAIIQGTGAAALWIVALIAFAECGLAVFFMPGDSLLFCSGNVCRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THL1</accession>
    <name>W4THL1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68420">
        <property type="protein sequence ID" value="GAE68420"/>
        <property type="gene ID" value="JCM18909_1556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6294" checksum="6A6FCED09F99F925" modified="2014-03-19" version="1">MEMAGIEPASLKDRPDILRAQSMLSLLLGSCTHTDMVQTSPVTETSRAASVTTAARQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN8</accession>
    <name>W4THN8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulphide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68311">
        <property type="protein sequence ID" value="GAE68311"/>
        <property type="gene ID" value="JCM18909_1439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9106" checksum="9E535B86A1F92B27" modified="2014-03-19" version="1">MSAETMTSDTTDPNGYVIRENQDITARPDLARTAGRVTPTRTRRPVYLDMLPPCNAGCPAGENIQEWLRLIKAHEEGRHGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT5</accession>
    <name>W4THT5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fumarate hydratase class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68500">
        <property type="protein sequence ID" value="GAE68500"/>
        <property type="gene ID" value="JCM18909_1642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="2">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19375" checksum="884771A82F2378FD" modified="2014-03-19" version="1">MKIANDVRWYASGPRNGIGELLIPENEPGSSIMPGKVNPTQCEAMTMVATRVFGNDATVGFAGSQGNFQLNVFKPVMAHACLETIRLIADSCISFDKHCAYGIKPNPDKIKENLDKNLMQVTALNRHIGYDLASKIAKNAHRKGISLRESALTVGGMSEEDFDKWVVPADMTHPSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW5</accession>
    <name>W4THW5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68112">
        <property type="protein sequence ID" value="GAE68112"/>
        <property type="gene ID" value="JCM18909_1228"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13347" checksum="E9D0C9D3D17F4AD6" modified="2014-03-19" version="1">MGEFRGNPQLVHPDFVMTDRNGKVVAGREEGKVMAAQVQRHGLLGLYPQTSKLRTWEIASVESMLLESTPELEDTLPEWLRQEADLPSLWELTTPSIIRIRWLRLIAAPNDLSGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI10</accession>
    <name>W4TI10_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68401">
        <property type="protein sequence ID" value="GAE68401"/>
        <property type="gene ID" value="JCM18909_1536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008523">
        <property type="entry name" value="DUF805"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34980">
        <property type="entry name" value="PTHR34980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05656">
        <property type="entry name" value="DUF805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="24301" checksum="F032328B98D103E3" modified="2014-03-19" version="1">MAERAGRNPYGQPSNPFQVPAPYSSCFPVAENHRRPYVDFGLAIKLFFKNYAVFFRGRASRSEYWWTVLFNFIIAVAMQALMPILQGAGLMSAITSNSTTEFSAMPTSGVIFTMPPLAWLLAVIIPCLALTVRRLHDVNHSGWWVMAPTLCGIASAIMMILAFVSAAANDGKPSMALLTIGIVLFVAIFVVNIILLIFVISDSHPEAWKKYDKEPLPVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI12</accession>
    <name>W4TI12_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphocarrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68068">
        <property type="protein sequence ID" value="GAE68068"/>
        <property type="gene ID" value="JCM18909_1180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10304" checksum="AC959F2BED56D9B3" modified="2014-03-19" version="1">MIRTEVTIGHPAGIHARVAAQAVLLASGHSASVFLRSSRGTASLTRLADLLRLDVREGAVVEILADGPDEVEALHEVATFLTSATNDPAPHPASDEGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB4</accession>
    <name>W4TIB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylmuramate-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68700">
        <property type="protein sequence ID" value="GAE68700"/>
        <property type="gene ID" value="JCM18909_1851"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="195" mass="21166" checksum="795675F9BED94C5A" modified="2014-03-19" version="1">MSLREPVELLDPSAVGPVHFIAIGGAGMSGVARIYHDMGVEVRGSDQVDSANLRDLASLGVQTWVGHDPSHLAGARTVVVSSAIRPDNPELVEAHRLGLRIWHRSAALAALMLGREASQSLVHTAKQRQPAWLPPCSIVPELTRPMSLALHWLPRACPPILVGEKLSWWRLMNPMGLSCSTQARSSSSPMWKPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG1</accession>
    <name>W4TIG1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68755">
        <property type="protein sequence ID" value="GAE68755"/>
        <property type="gene ID" value="JCM18909_1912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9292" checksum="99C2B5BED38E2717" modified="2014-03-19" version="1">MKAELARCQQAWRRVVACAVEAGVPVPGFSSALGYYDQVRAPRLNAALTQGLRDLFGAHTYRRVDDEGSWHLNWSGDGREVCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIK7</accession>
    <name>W4TIK7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin carboxylase</fullName>
            <ecNumber evidence="1">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Purine metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68800">
        <property type="protein sequence ID" value="GAE68800"/>
        <property type="gene ID" value="JCM18909_1963"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="65"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="345" mass="37306" checksum="E9BFBEF6ACD2307B" modified="2014-03-19" version="1">MMSDVVVGSHLDHDAVMNFAAGCDVVTFDHEHVPTVLVEEMEEAGYAVRPGSAAMVHAQDKVVMREFMEREGFPNPAWQVCDTPEDLVSFGHDRGWPVIAKTSRGGYDGKGVFKIDGPDGVGEPFDAAGDLADGKQPIRILAEEFVDFRRELSAVVVRSPSGQGAAYPVTETVQRHGVCAETISPAPDLSSDRQVELQTMALDIAGRLDVIGVLAVELMEREDGSVVVNELATRPHNTAHWTIDGAETSQFENHMRAVLNLPLGSPALTAPVVVMANVLGGSEEDLTGALQHCFARDPELRVELYGKSVRPGRKVGHVTCLGNDIETTHRRARHAAAYLMGEHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIW4</accession>
    <name>W4TIW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68363">
        <property type="protein sequence ID" value="GAE68363"/>
        <property type="gene ID" value="JCM18909_1492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5274" checksum="D396AFBB4E4103B8" modified="2014-03-19" version="1">MSQGGSSLIANWVIVAIIMIVSHRNRKPADDFVATVPAPDPQQAVTGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY0</accession>
    <name>W4TIY0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhs-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68378">
        <property type="protein sequence ID" value="GAE68378"/>
        <property type="gene ID" value="JCM18909_1511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15491" checksum="61B0B22C01C63590" modified="2014-03-19" version="1">MELRLQRGWVTHQRDGRTQHTWTHDAYGRLTSHATSGTDTTFTWDQEGHLAQTCTRAHGHATATQYRYDAAGRRISATSPDGQEERYSWDGRGWLSGITTDATTVSTHIDALGRASRITTKGQQVRVDWDLVTGPHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC2</accession>
    <name>W4TJC2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68508">
        <property type="protein sequence ID" value="GAE68508"/>
        <property type="gene ID" value="JCM18909_1651"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7722" checksum="099C6DB0C1E987E4" modified="2014-03-19" version="1">MHEVARVAGVSHATVSRVLNGHTNVAPATARAVADAIITTGYVPNRAARSLRVQSTDTVVLVAREKSRRFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJJ1</accession>
    <name>W4TJJ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68319">
        <property type="protein sequence ID" value="GAE68319"/>
        <property type="gene ID" value="JCM18909_1448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6149" checksum="C2861B1FAA773218" modified="2014-03-19" version="1">MANDKARHVRETEAEYVVAGDNSCLMNIGGVLSRQNSGVKRFTSPKSSPTLRRTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL8</accession>
    <name>W4TJL8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68618">
        <property type="protein sequence ID" value="GAE68618"/>
        <property type="gene ID" value="JCM18909_1765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="9788" checksum="86A1F9CD6874F17A" modified="2014-03-19" version="1">MTALLTSAAVAYAGVITFVGLIVPHVLRLLIGPANKWLIPSALLGGCLLVTLSDIAARTVVPYADLPIDIFTAIVGGPTFFILLRRGMGGEKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS2</accession>
    <name>W4TJS2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68782">
        <property type="protein sequence ID" value="GAE68782"/>
        <property type="gene ID" value="JCM18909_1939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26785" checksum="4653AE6B83AF302E" modified="2014-03-19" version="1">MPENFTPYGHQARAFTRLNSALGRPRPTLVTTGTGSGKTEAFLLPILDHIVRARRNAVTGTKALILYPMNALANDQAQRLAHLISTDTQLAEVTAAIYTGEQGPSLTIVSKDGLITDRTIIRDDAPDILLTNYKMLDQLLLRHEDQRIWQQSAESLQYLVLDEFHTYDGAQGTDVAMLLRRLGLASSRTGQSAVARLTRAPSRSGTARLARSPPSAPRRPWAPLLTSLRPLPSLRPRPPRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX9</accession>
    <name>W4TJX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68738">
        <property type="protein sequence ID" value="GAE68738"/>
        <property type="gene ID" value="JCM18909_1893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="12547" checksum="3A738BFDAD984DF2" modified="2014-03-19" version="1">MNYAFERAHAPHVDPEWTNAFIVEARLANLNGTTIGDALAEIDAHVVSSGESAKAAFGDPRSYAQALATSAGASPTSTVGAVTAPAAQTIGVILIPIGIMHCATTIGLISRRGYLLQRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK60</accession>
    <name>W4TK60_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-binding response regulator KdpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69340">
        <property type="protein sequence ID" value="GAE69340"/>
        <property type="gene ID" value="JCM18909_2545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="88"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="88"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="21189" checksum="C904F6FD3524252D" modified="2014-03-19" version="1">MAIDHKPDIILLDLGMPRLDGVQVIEAVRGWSSAPILVISGRSGSAEKVEALDAGADDYVTKPFSMDELLARIRVLTRRIGQDEVDEEPVVAFGSVWVDLAAHTVTRDGVNVRLTPTEWRVLELLIRNEGRLVTRQTMLSQVWGSEHVTDTGYLRLYISQLRKKLEPEPSRPRYLITDAGMGYRLVLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK63</accession>
    <name>W4TK63_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69191">
        <property type="protein sequence ID" value="GAE69191"/>
        <property type="gene ID" value="JCM18909_2383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="274" mass="29843" checksum="A28AF24B6E7ED3EF" modified="2014-03-19" version="1">MISDMDGTLLDGDGNIPSQLWPLLETMRDRAIAFVPASGRQCTTLSTMFGSHVQGMPIIAENGTYVVRDGIDISSSTIDPNLTREVITGVRQLRNDGRDVGLVVATKSIAYLERGDDPFVSHVATYYHSHRIVKDLSEHTDDVIKLSIYDFGEASESTYPTMQRTVPEHQVILATPNWVDIMNPGVNKGSAVEAVQRDLGVTADQTAIFGDFLNDLEMMPMAKWSFAMANGHPDIVKASNYVAPPNTENGVITVLAALLGTGVRPRDGHRSDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK69</accession>
    <name>W4TK69_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68828">
        <property type="protein sequence ID" value="GAE68828"/>
        <property type="gene ID" value="JCM18909_1992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6919" checksum="EB343D96ACAC14A0" modified="2014-03-19" version="1">MDESFPRPRCWNLVPPVCSWSTSVRGRTAVVRQTALADWIATRNWAKLEDQWARMVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD1</accession>
    <name>W4TKD1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68972">
        <property type="protein sequence ID" value="GAE68972"/>
        <property type="gene ID" value="JCM18909_2150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11419" checksum="7C67E311E4E5C48D" modified="2014-03-19" version="1">MNLAGIGIAGTWAMVLLAHTRFVSAVRRGEENRPEYRMPGAPITNYISLAFLLIVVLSNVTSESGRWTLALFALVAIAMVAGWYAVRNSIKPDLLDNVVPSDEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE2</accession>
    <name>W4TKE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69266">
        <property type="protein sequence ID" value="GAE69266"/>
        <property type="gene ID" value="JCM18909_2464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="26"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="214" mass="23135" checksum="8626A8CB04A8E1B3" modified="2014-03-19" version="1">MGLRDLLMNHGMAEGGLDLPDVLNALAKGAVLVDVRTAREYEAGHAPGARLVNPKELLADPFTAVYGDDPLAEPNPHFILVCDTGFRSGHLVAPVREKGYNCDFLASGLHAWRAVGDSHSWSATRSLKLTSRNGCQRLRSTSSFRGYAHPGALHNNPHKKTSPSYRSVGGRCVVMRQRRDLWVAVTVVVMTVPRPTIPAMPVRPIAGSPPVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG6</accession>
    <name>W4TKG6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69430">
        <property type="protein sequence ID" value="GAE69430"/>
        <property type="gene ID" value="JCM18909_2642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12759" checksum="18FC6649DCEA9CEB" modified="2014-03-19" version="1">MLREAGVEFRPRGGADPASPETKAGRETVETSQEADHNDSSNTDEVGGSSGNPEPSGTDVDALKLAVEAAVARAEKKADRKARKAEKALHKLRRTGAGKSRRKKTKATLHKRRAKAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN7</accession>
    <name>W4TKN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69510">
        <property type="protein sequence ID" value="GAE69510"/>
        <property type="gene ID" value="JCM18909_2735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13076" checksum="8C24CB26391F6267" modified="2014-03-19" version="1">MTMNDIPEASTTWCDPDQIGAPLPETDEVEADPQTVQIPPAESFEVLRRASEEELRAQERGEQLNPLESGRAAIAIALTPLCQLEGAVMLGVSLLEAVVKRVEQVDEDAVEAYLPDWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS1</accession>
    <name>W4TKS1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69545">
        <property type="protein sequence ID" value="GAE69545"/>
        <property type="gene ID" value="JCM18909_2772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9475" checksum="A65761CA1E2F8D22" modified="2014-03-19" version="1">MSNGTATARRNRSKAARAMDIRTVIGVLLGLYGIILTITGLVKGSDAHADLVSGMCLLVAGAVFLVWVRLRPVKVPEVAEETSEPTVGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU3</accession>
    <name>W4TKU3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide transport system permease protein OppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69147">
        <property type="protein sequence ID" value="GAE69147"/>
        <property type="gene ID" value="JCM18909_2336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="98"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="327" mass="36167" checksum="F94D60C6DD7A4B03" modified="2014-03-19" version="1">MLKYVVRRLINYVVLLFIAVSFAYLLASYALDPRNAFDQTNPKLNWTAINQSLTNYNINPDTSISVRYERWLKMVFLHWNWGWTPHGDAINSLIGTRIGVSVRLVICGTIIGMVGGVAISAWSAVRQYSAADRIVSFLCLLLISTPTMVLAVLLQLCAIRFNQAIGTQFFQFIGEVGSHGNYFGAEFLSRMQHLLLPTISLSALSLASYSRYQRNLMLDTLGADYVRTARAKGLRKGRAIRHHALRNAIIPMATYFAFGVANIFVGATISEQVYAWNGVGSYSVMSIQQNDINGSVAVVAFSGLCTLTGALLSDILIAVIDPRVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV1</accession>
    <name>W4TKV1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SSU rRNA (Adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69058">
        <property type="protein sequence ID" value="GAE69058"/>
        <property type="gene ID" value="JCM18909_2240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="5">
        <location>
            <begin position="37"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30454" checksum="0B0F866830907318" modified="2014-03-19" version="1">MSETGLLNPASIRRIADQIGLRPTKTRGQNFVHDANTVRRIVSLAQVGAADRVIEVGPGLGSLTLGLLETGAEVVAIEIDEMLANQLPDTVAERMPGAVERLEVVLSDALDVKVIPGAEPTALVANLPYNVAVPVLLHMLAICPQWSTGVVMVQSEVADRLVADPGSKIYGVPSAKLAWYAEAFRSVTFPRRSSGQCPMWIPGWSGLRDGVLPTSTGGTRASPVPKSSALSTPLSPLAAKCCARPWPSYAVVQWRLPSSLPPLELTRRRVAKPSILAIWPALQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL25</accession>
    <name>W4TL25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyphosphate kinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69237">
        <property type="protein sequence ID" value="GAE69237"/>
        <property type="gene ID" value="JCM18909_2431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="3">
        <location>
            <begin position="71"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="32856" checksum="023464A2397FC483" modified="2014-03-19" version="1">MYDLGSSPLPTSFDPATDSDQHSLREFIDLVADAGYVVDSDEHGDDPELIAPDGSAVETWHEDYPYPNLMDRREYETQKRLLQIELLKLLYSIDDTGERHVIIFEGRDAAGKGGAIKRFSEHLNPRRCRVVALDKPSDRELGQWNFQRYIQHLPTAGEIVLFDRSWYNRGGVERVMGFCTDEEHRIFLRQAPILEEMMIESGIHVTKFWFSVTRQEQRTRFAIRQLDPVRRWKLSPMDLESLGRWDDYTRAKEEMFAATDTDAAPWICIKSNDKKNARVLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL59</accession>
    <name>W4TL59_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsF</name>
        <name evidence="6" type="ORF">JCM18909_2466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69267">
        <property type="protein sequence ID" value="GAE69267"/>
        <property type="gene ID" value="JCM18909_2466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="11223" checksum="2E3A2CFBC27C7755" modified="2014-03-19" version="1">MRKYEVMIIIDPTVEERQVDSLMEKYLKVITDEKGTVDNVDVWGKRRLAYDIQKKSEGIYVVVNATCEPATIQELDRLLAIDEKIMRAKVMRPEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG6</accession>
    <name>W4TLG6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69283">
        <property type="protein sequence ID" value="GAE69283"/>
        <property type="gene ID" value="JCM18909_2483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7134" checksum="3D892A9063F14952" modified="2014-03-19" version="1">MVMVGQFPSLLGWLTQWARTAARNRPHFRSGKRVNLLNRAVGQLPVVRVVVHFTGSINSRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL2</accession>
    <name>W4TLL2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69870">
        <property type="protein sequence ID" value="GAE69870"/>
        <property type="gene ID" value="JCM18909_3133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="99"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="267" mass="28488" checksum="82BC933247FE452D" modified="2014-03-19" version="1">MKVRWLSTGGEVRCYRVIHRWKISWRRSRSVTITEDMRRSVCISLLIIMVGICLLALPAHSRSVAALPARSVANRPTPPVLGPVIKGFAPPAERWLPGSRGVEFAASVGEPVTTVTAGVVVFFAGQVAGTGVVSILLADGRRTTHMPVVPSVAVGQVVVPGQQIGVVGMGPPCTRTCVHWGLKKRDVYQNPMTLLQLQVRLLPLDSRPHSASGHEWPVRPLSLPGGSRKKAASSGALMPPWRGAGRDAALGIDMTVTEATRGGQARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM1</accession>
    <name>W4TLM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69402">
        <property type="protein sequence ID" value="GAE69402"/>
        <property type="gene ID" value="JCM18909_2611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="22385" checksum="D5005A1B5E67384B" modified="2014-03-19" version="1">MTARDRRLYGWCIAALVTNMGIVVTGAVVRLTGSGLGCNTWPHCTDGSFTPHEAMGIHSFVEFGNRLLTFVLVAVAIGALVRCYRVKITAQLMALCWINLVSIALQAVIGGVSVRVGLNPFVVTLHLLMSVAIILVNVKMIWLVGPHSSEAVDGLTMGLVRATVAMMCVVMWLGTVVTGSGPNAGDSGSARTGSTSKPSRGCTASRCGSRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN2</accession>
    <name>W4TLN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pyrophosphate-energized proton pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69407">
        <property type="protein sequence ID" value="GAE69407"/>
        <property type="gene ID" value="JCM18909_2616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="360" mass="39017" checksum="601EB6F99199B3C7" modified="2014-03-19" version="1">MICLFGLGFGLVTYSKLEKLPVHEAMHEVSELIYETCKTYLKQQAKFLMLLWAFIAAVIVVYFLFLEHMGAKVLIILLFSLVGMAGSFGVAWYGIRVNTFANSRTAHASLRGSPWATFDIPMRSGMSIGMVLISVELTLMLFIMLVLPGDLAGPCFIGFAIGESLGAACLRIAGGIFTKIADVGADLMKIAFHIKEDDARNPGVIADCTGDNAGDSVGPSADGFETYGVTGVALITFVLGAVPDQTEQVQLLVWIFVVRVVMLIASFVSYLINNAVAKARYGTVSEMDFEKPLSSLVWITSVMSILLTVLTTRWMLGSMGDGTMWWKLSIIISCGTLAGASFRSSSRPSPQRILVTCVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS0</accession>
    <name>W4TLS0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69134">
        <property type="protein sequence ID" value="GAE69134"/>
        <property type="gene ID" value="JCM18909_2323"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="7">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13353" checksum="F3ABB660FA970C63" modified="2014-03-19" version="1">MAFGDYGIQATEGGYLTNRQIEAARIAMTRYIKRGGKVWINVYPDRPMTKHPAESRMGSGKGTPEWWIANIKPGRVLFELSGVPEEVAREAMRLAIHKLPMKLVSSPVKVVTTDAEAFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV0</accession>
    <name>W4TLV0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">JCM18909_2360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69169">
        <property type="protein sequence ID" value="GAE69169"/>
        <property type="gene ID" value="JCM18909_2360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="261" mass="28010" checksum="3FDBB63406D09A43" modified="2014-03-19" version="1">MDPGHTPIRHMTGKGRGGRPSSLSRTAAGPPARHTDTQGEKNAETHKGPRLGGSPAHERIILRNLASQLFEHGRVVTTVTKAKRVRPLAEKLINRAKTDTVANRRFVNRTITDRGIVHILFTEIGPRMEGRDGGYTRVTRIGNRKGDNAPMAVIEVISDKVAPKAPASAADAKAQINTATEAKDAEPEAGDAAVEHNAPAEDAAAQAPVADEQEAAEADEKAEEKPEADPPSKRRSSLVRTGVYYACAPSQPLVSRFRFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV4</accession>
    <name>W4TLV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69945">
        <property type="protein sequence ID" value="GAE69945"/>
        <property type="gene ID" value="JCM18909_3217"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10978" checksum="D5421C53E5B2AD0F" modified="2014-03-19" version="1">MNGMGLVARQRDPHDARSRLVEITDAGREYCRNCGLSVGESVVPVLNTLSDRDRGLLMRVLPALRRAVEVLSENVDRTFQPHSMVTDWKSVTPLMLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX7</accession>
    <name>W4TLX7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69975">
        <property type="protein sequence ID" value="GAE69975"/>
        <property type="gene ID" value="JCM18909_3251"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="8060" checksum="CD0C6876A402B07E" modified="2014-03-19" version="1">MRYCGLVVEVNRLDDCGHRAHGPGDQLRHPADPDLDRQVSWLFPLVFEPRRRRVDRLPTEFSFPLQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ1</accession>
    <name>W4TLZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69766">
        <property type="protein sequence ID" value="GAE69766"/>
        <property type="gene ID" value="JCM18909_3017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="272" mass="29577" checksum="F51C37729938E547" modified="2014-03-19" version="1">MSCADYAVMGVPQVVCPSQLPDLDQIAALCESGWYDTADSMLRVAHASESDNPHVVQAAAVMAVARRVLALDAEDFEDIGEALPADLRSRLVDSGFPHHPRAAERGALGDLIPLYELMLEVLDIRMRREEPQQVVVTCHILGEYLAQLAWQSVLGDGGDPLTLPGKVGQKWGGDGQGCAHTSAMNATARRSMHAAQGDEEGYTSYLDKFHSRLGEALGVCAMNHATIDAGERPDVGITCPDPCRWVLTGTWEERRALDARVRLARIFFKSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM16</accession>
    <name>W4TM16_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuA</name>
        <name evidence="5" type="ORF">JCM18909_2653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69438">
        <property type="protein sequence ID" value="GAE69438"/>
        <property type="gene ID" value="JCM18909_2653"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="58"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="577" mass="64413" checksum="1F2583C5DB52A024" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM56</accession>
    <name>W4TM56_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_2474</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UppP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69274">
        <property type="protein sequence ID" value="GAE69274"/>
        <property type="gene ID" value="JCM18909_2474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE69274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17345" checksum="19D93140EA71F629" modified="2014-03-19" version="1">MVAIALIFWSGVMWLGDRQLSLNRGMKEIGIVDAIVIGCFQALAPLFPGISRSGATISAGLFRKFDRATATRLSFFMGIPALVAAGIYESVSAASDISIAQGGAVAIGWGPTILATVVSLIVAYVSIAWLLKFVSSNKFTGFIWYRVVVGLIMIGLILSNVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM65</accession>
    <name>W4TM65_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cob(I)alamin adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69622">
        <property type="protein sequence ID" value="GAE69622"/>
        <property type="gene ID" value="JCM18909_2861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16572" checksum="8AE07AAE06BFD270" modified="2014-03-19" version="1">MPHARTSAEPDDGLSTRQRRLRPVLVVNTGEGKGKTTAAMGTALRAWHQGWRVGVFQFVKSGRWHVGEEDALRALGQLHEETGVGGPVTWEVMGTGWSWTRSFDTAENPEVAAREGWRHVSNLLAHEALDFYLLDEFTYNGLGMARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMC0</accession>
    <name>W4TMC0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="6">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69682">
        <property type="protein sequence ID" value="GAE69682"/>
        <property type="gene ID" value="JCM18909_2927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLA_N" evidence="7">
        <location>
            <begin position="67"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="337" mass="38246" checksum="479FA17064AF7DEC" modified="2014-03-19" version="1">MKSRFGKYFEGSMGAEAVKRRLHDFDLKSESEKLREIIKTGRGQKKTRALKRLKVVQAFLDSGNSPEAMVLDCVPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLVDLGAPEIIVNNEKRMLQEAVDSLFDNGRRGRPVSGPGNRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKMHQCGLPKTMALELFKPFVMKRLADLEHAQNVKSAKRMVERQRPVVWDVLEEVIKEHPVLLNRAPTLHRLGIQAFEPQLIEGKAIQLHPLVCSAFNADFDGDQMAVHLPLSLRPRLRPASSCCRRTTFSSRLMVARSLCLRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF0</accession>
    <name>W4TMF0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PspA/IM30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PspA/IM30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70160">
        <property type="protein sequence ID" value="GAE70160"/>
        <property type="gene ID" value="JCM18909_3456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007157">
        <property type="entry name" value="PspA_IM30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31088">
        <property type="entry name" value="PTHR31088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04012">
        <property type="entry name" value="PspA_IM30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="55"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="267" mass="29497" checksum="CD13A563A258C1AC" modified="2014-03-19" version="1">MAGIFARLSTVFRSKANKALDKVEDPRETLDYSYQRQLDMLQKVRRGVADVATSRKRVELQMNQLQTDVDKMQNAASRALEQGREDLAREALTRKATLQAQLNDLQTQHATLQAEEEKLIRGSQRLQARVDAFRTKKETIKATYSAAEAQTRINEAFTGLNEEMGDIGMAITRAEDKTMELQARAGAMDELIASGAIEDPTRSYGDDITRELDSLADDHAIDAELSALKAQLGAGRDGSAPELESGAENGTDPHTGSRSVRRQEDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML5</accession>
    <name>W4TML5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69787">
        <property type="protein sequence ID" value="GAE69787"/>
        <property type="gene ID" value="JCM18909_3039"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoeA_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="15195" checksum="52297C5391D045FD" modified="2014-03-19" version="1">MSIARHLQLVSSLATAPKTVELPLAECLGLVSAGPVTAQLTVPPFTNSAMDGFAVRHADVSEATAHTPVTLPVTDDVPAGSPAYRPLDPGTAQRIMTGARMPENADTVIKVEDTDHAPGIVDAPATVTIFFAFPQPAPMCDAVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMP0</accession>
    <name>W4TMP0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription termination factor Rho</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69976">
        <property type="protein sequence ID" value="GAE69976"/>
        <property type="gene ID" value="JCM18909_3252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8104" checksum="FE83D11074FF1BC8" modified="2014-03-19" version="1">MGIKGARGMRKADLIAAISEGGYPEVGRPAARQNRGQESGTSSDEAGNSAPSDAVVRRLLRTPNSINLQGERKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX6</accession>
    <name>W4TMX6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thymidine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69892">
        <property type="protein sequence ID" value="GAE69892"/>
        <property type="gene ID" value="JCM18909_3157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="3">
        <location>
            <begin position="40"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="222" mass="23094" checksum="1A88CC145F619BF4" modified="2014-03-19" version="1">MSAMAMAVYFQGLDDVELSAWTTAMIESGERMSFAGLSRPTVDKHSTGGVGDKITLPLAPLVAACGAAVPQLSGRGLGHTGGTLDKMEAIPGWRADLSHDEMVAQLEKVGAVICAAGPGLAPADKKLYALRDVTGTVESIPLIASSIMSKKIAEGTDSLVLDVKTGSGAFMKTDKDARELASRLVELGEAAGVRTTALLTTWTSHWVTPAVTASRLPNPSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ4</accession>
    <name>W4TMZ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69783">
        <property type="protein sequence ID" value="GAE69783"/>
        <property type="gene ID" value="JCM18909_3035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="7903" checksum="80E99A9A9F92F650" modified="2014-03-19" version="1">MTAPEGSLWDDVVVTAPTYVSTPLGARTVRTIDLSAPGPVPGQVDTPVVAEKPVERSDGEHVAEAHEGPSGIVGVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN06</accession>
    <name>W4TN06_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69798">
        <property type="protein sequence ID" value="GAE69798"/>
        <property type="gene ID" value="JCM18909_3053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="310" mass="33089" checksum="D3298B583225A9BE" modified="2014-03-19" version="1">MGWKWAQATTTDGKQLGIPSDIGPTVLFYRADIFEQAKLPSDPDQVAAQMTTWDAFIEFGTKLLATKKKTYLVRNAAGLFGTIWPQSGKGFIDEKKTFIGDQDHIRNAWDITAKALKAGIIATIQSDTSDAAAAVNEGRLPADFGASWHLADLMVDAPQTKGKWRACAHPGPAINQGGSFLSIPAGASDPKASFAAIRELLSVKSQIREYVHNGNFPVSPKAYDDPKVSGPVDFLGGQHAAKVFGKAAESVRPLFEDSNSGAVSAPFAAQLERSNPRERIRKLPGTMPSPRLSASPGNCISPSGEASVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN07</accession>
    <name>W4TN07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR-family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70360">
        <property type="protein sequence ID" value="GAE70360"/>
        <property type="gene ID" value="JCM18909_3676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4095" checksum="3A6BF1B4230421D4" modified="2014-03-19" version="1">MSASSPKLIDRSPDPDDRRANVLSLTNRGATLVQKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN35</accession>
    <name>W4TN35_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CTP synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="4">6.3.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_3195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69927">
        <property type="protein sequence ID" value="GAE69927"/>
        <property type="gene ID" value="JCM18909_3195"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="251"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE69927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="506" mass="54917" checksum="630E517284AD1EC4" modified="2014-03-19" version="1">MNPFQHGEVFVTEDGAETDLDIGHYERFLNENLSGQANVTTGKVYSAVIAKERRGDYLGDTVQVIPHITNEIKERMLAMEEGHPDVVIHEIGGTVGDIESLPFLEAARQVRHEIGRENVFFLHVSLVPYIKPSGEMKTKPTQHSVAALREVGIQPDAIVCRSERPIGKGIKSKIALMCDVEGPAVVSCPDAPSIYLIPKVLHREGLDAYVVQKLSLFFRDVDWTTWDDLLDRVRKPRSEVTVALVGKYIDLPDAYLSVTEALRAGGFANKAKVNVVWVASDSCATAEGAAQQLRDADAICVPGGFGIRGVEGKIGAIRYAREHKVPFLGLCLGMQCAVIEVARDLAGIKDAASSEFDSQTPDPVIATMAEQVEAVAGKADLGGTMRLGAYPAKLAKDSLVAELYGTTTVTERHRHRYEVNNAYRVRLEQAGLRISGTSPDGGLVEFVELDRQTHPYFVATQAHPELKSRPTHAHPLFRGLVAAAVGHAKAASKGAAKESSTKVADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN76</accession>
    <name>W4TN76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70186">
        <property type="protein sequence ID" value="GAE70186"/>
        <property type="gene ID" value="JCM18909_3484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5768" checksum="48632AF941772AAF" modified="2014-03-19" version="1">MEAAIRPRDPIDPEASTTKIAQEAARPARTLARQSIGLTCTARSGRSVARRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH4</accession>
    <name>W4TNH4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70510">
        <property type="protein sequence ID" value="GAE70510"/>
        <property type="gene ID" value="JCM18909_3838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13477">
        <property type="entry name" value="Glyco_trans_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8308" checksum="BA74CC5212681502" modified="2014-03-19" version="1">MQPDIVNVHYATGYGLLARLAHIDAPTLLSVWGSDVYDSPRVNPSCVTWSDPTWSQLLGSHRQATAWRVSRVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL7</accession>
    <name>W4TNL7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000052">
        <property type="protein sequence ID" value="GAE70555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70555">
        <property type="protein sequence ID" value="GAE70555"/>
        <property type="gene ID" value="JCM18909_3897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="145" mass="15932" checksum="638104E5A7C87600" modified="2014-03-19" version="1">MNPKNSKATELWFPDNSDSPCTLLLDLSRASTEDTEPSPQYYCRTWDPTTKDPGVRVGILDSNRLTDQAAFLGGSGITHHFLVMKKTTQLAPSMERGFRGLEAFHDKQTIVHRVISMDGKVGATGIGLDGRRTPSGSYETSSCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM3</accession>
    <name>W4TNM3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69809">
        <property type="protein sequence ID" value="GAE69809"/>
        <property type="gene ID" value="JCM18909_3064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="429"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="532" mass="56321" checksum="51BE6FC1D1FE5BC0" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP6</accession>
    <name>W4TNP6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70162">
        <property type="protein sequence ID" value="GAE70162"/>
        <property type="gene ID" value="JCM18909_3458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="FeS_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="FeS_cluster_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="SSF89360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00049">
        <property type="entry name" value="TIGR00049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S_biosyn" evidence="1">
        <location>
            <begin position="13"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12484" checksum="5685FDE29AC3A9D0" modified="2014-03-19" version="1">MTDALTPPAIDGIILTDAAAAKVKSLLDQEGRDDLALRLAVQPGGCSGLRYQLFFDERHLEGDVVKTYGGVDVVTDRMSAPYLAGATIDFMDTIEKQGFTIDNPNATSTCACGDSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNS1</accession>
    <name>W4TNS1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ChlI component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70187">
        <property type="protein sequence ID" value="GAE70187"/>
        <property type="gene ID" value="JCM18909_3485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6811" checksum="9AB751A508C7A7A9" modified="2014-03-19" version="1">MAASKGAVLSLLLDAYIKCDRVCLISFRRDRAEVLVPVTSSVEVAQHGLAELPVGGRTRCRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNU7</accession>
    <name>W4TNU7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acylglucosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="4">5.1.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70396">
        <property type="protein sequence ID" value="GAE70396"/>
        <property type="gene ID" value="JCM18909_3714"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12592" checksum="5C63D8347488C3F2" modified="2014-03-19" version="1">MSLAETIERLKREYDVVVMADCGSVDDGLFAAEAGADLIGTTLCGYTGECPKTDGPDYEVIEALVKKLDGDRPVIAEGRIHTPDQARCAMNLGAHAVVVGTAITHPTSITGWFRDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP48</accession>
    <name>W4TP48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69964">
        <property type="protein sequence ID" value="GAE69964"/>
        <property type="gene ID" value="JCM18909_3238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850858" evidence="2">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8540" checksum="020A660AA7E767DA" modified="2014-03-19" version="1">MTLVMTVMVRPRVPTAFSGLAGTVVAVAFFWRAAVAFICSTGAAPGFSALDCSSSKLVFWAALGLWYPSTALGLFRFHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPB2</accession>
    <name>W4TPB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000052">
        <property type="protein sequence ID" value="GAE70556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70556">
        <property type="protein sequence ID" value="GAE70556"/>
        <property type="gene ID" value="JCM18909_3898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="156" mass="18283" checksum="E1B3ACDCA84EAA45" modified="2014-03-19" version="1">MLGRLPLKLSLRLITYRSHYESIRARTIDPKAMDTAVNRAFMKYQDELQRWSQSLTCSSSYREKEWTNPNLSEWSAIIYCHLPQIRKLLSGGGLTVAGPTREDIEASLGHSIPDTRFHERLDPAMQYYLNHDQDFTAYRFCTGFFCTATCTRWEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPD8</accession>
    <name>W4TPD8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70586">
        <property type="protein sequence ID" value="GAE70586"/>
        <property type="gene ID" value="JCM18909_3936"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="244" mass="27341" checksum="2399C3123559A137" modified="2014-03-19" version="1">MRDDQEQRRPAPHRPPDPETVWLDIDTARGVDAAGNEILPVLGGRRTKRATLSDLLTTALHHNARRLIVCGNIPDQPQSWLLPDTPAHTREFNQDWHVRGLFMLSGRPARGRFTHKETDRNLDILVADEWFPGQTLTPVQARWAWRELTHIIATRIDRDWASWTAPEQKESTSGSYGPPSPIAWSRWTPNWAHSSNTPPLSTATNYASTTATPRTGNKVGVPSCLPALSLTSYTWTAGSCMPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPG0</accession>
    <name>W4TPG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70094">
        <property type="protein sequence ID" value="GAE70094"/>
        <property type="gene ID" value="JCM18909_3384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021904">
        <property type="entry name" value="DUF3516"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12029">
        <property type="entry name" value="DUF3516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="513" mass="58076" checksum="C3E95AF98D1BF3ED" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPJ6</accession>
    <name>W4TPJ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70134">
        <property type="protein sequence ID" value="GAE70134"/>
        <property type="gene ID" value="JCM18909_3430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10029" checksum="D232126FF829884E" modified="2014-03-19" version="1">MVWRKTGFSSDEQDALDLVPVTTCDPKKIPTAGKLHQPTLAKLVRVNFPLPQSGGGSQNSGVLPLQRRQMPDSHNVSSDAPCSGSTTAPHRAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK4</accession>
    <name>W4TPK4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000061">
        <property type="protein sequence ID" value="GAE70666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70666">
        <property type="protein sequence ID" value="GAE70666"/>
        <property type="gene ID" value="JCM18909_4037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22147" checksum="0B2085234F0722F1" modified="2014-03-19" version="1">MGAADLAEAFIGELSDGQRQRVMVARALAQEPSILLLDEPTSFLDPPGRIALLGMLREVCTDRNIAVVVCSHDIEPVMRYADILWVAGHDTDVIIGAPEDLARNGALEAAFRTEGITFNLRTLTFWQSDAGRPVARVVGHGVDADLAHHVLTRSGYRVVEQPGDEVLTVGVTDEGWAVDDCVLPTLSQLHEHLISRHGERTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK6</accession>
    <name>W4TPK6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SBP_bac_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70437">
        <property type="protein sequence ID" value="GAE70437"/>
        <property type="gene ID" value="JCM18909_3755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12788" checksum="D0772DB906090F67" modified="2014-03-19" version="1">MTLSPSPRPWHEGNRPTVRFAYYSDPTSQTAALLSGDLDVVSDMTTPQALSRFTGNPNYRVLRGTTNGEVVLGMNNTSKALSDRRVRQAILMAIDRKGLLDVVWNGQGTLIVDGSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPL2</accession>
    <name>W4TPL2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type sugar transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_4052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000064">
        <property type="protein sequence ID" value="GAE70676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70676">
        <property type="protein sequence ID" value="GAE70676"/>
        <property type="gene ID" value="JCM18909_4052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19485" checksum="BB929786C393B563" modified="2014-03-19" version="1">MAGLFINVNYIVVPIFLMLLGWDQALASWLPNGFFIDNLAVLALVYAATSLPFTIYLLVSFFRTIPAIYEEAAALDGSSRLRTMLSIMVPIVRPAISTVILFNFLSFWNDFIISLTLIPGEHKTLQVGLLNLFQAQRAAADYGRLYAGMVIVMVPVLLLYAIIQKRLVTGIGGGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM3</accession>
    <name>W4TPM3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70169">
        <property type="protein sequence ID" value="GAE70169"/>
        <property type="gene ID" value="JCM18909_3466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="292" mass="31746" checksum="C4C5ED2266CC7C59" modified="2014-03-19" version="1">MRHRGHTRSTCHEALRLRHHPPGRANRRMNRRLTAQTFRIWTRSKHRISLSCPFAVVIACFIALYLTLSSFALTGSQKRISYLDGHDASITISQTQTTLRPAQGTVIDRLRKSGARNISVITTGSSFQIDGLRTTGLSTGFHDRIQYMEWASGSPASRYHLTAGRWPSSPGEVALSGPLAARLHDPSRIHVFSDTSRLRVVGTFHDAYATDALVAIGAASGWKSMSAAASKGYPSLSPIVEYVWDGLPLSTAIPLFSTLYGTPTDSLVTSSRDGAKISASPQVSLASRSPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPP2</accession>
    <name>W4TPP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70487">
        <property type="protein sequence ID" value="GAE70487"/>
        <property type="gene ID" value="JCM18909_3814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="15026" checksum="3292E03EE66726D0" modified="2014-03-19" version="1">MIDAWMEGSTFTVTGVDWPTRDGSGIRDYIHVWDLARAHVAALEHLDEVTTEDPHQVFNIGTGSGVTVKELVKAFEEGTGKSLNVVYGPQRPGDVAGAYTVSRRAKDLLGWSAELTQADGIRDAIAWLPERKKILGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPX2</accession>
    <name>W4TPX2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70582">
        <property type="protein sequence ID" value="GAE70582"/>
        <property type="gene ID" value="JCM18909_3932"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9551" checksum="2CAEB2E61A57E676" modified="2014-03-19" version="1">MTTALIWMHTGALLLVWDIAVLTGPALGHCVYPLSNSAELTARRWLDQVADNPGFLNTLTEAARITEGWHHATPPHIQAPYRTLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPY0</accession>
    <name>W4TPY0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thymidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70289">
        <property type="protein sequence ID" value="GAE70289"/>
        <property type="gene ID" value="JCM18909_3597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="671" mass="74064" checksum="DFADE0BAA4CC5623" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQV6</accession>
    <name>W4TQV6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="7" type="ORF">JCM18909_3980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70624">
        <property type="protein sequence ID" value="GAE70624"/>
        <property type="gene ID" value="JCM18909_3980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009993197" description="Probable endolytic peptidoglycan transglycosylase RlpA" evidence="3">
        <location>
            <begin position="36"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="6">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="493" mass="51703" checksum="BEBADD5361A1CD5E" modified="2014-03-19" version="1" precursor="true">MIRPKRSVRGAAATIALTSGISVVAPAVIGSVAHAANTQTMYTTADVNVRSASSNSGKVLTVAARGQSVRVTGEKVRGWVPVAVNGTSGWIYQRYLTEENVHPVHFGSDPLPDTMIAAVPVNVRSDSANAGKVLTVAERGQQVQVIGRPDGGWVPVSVNGKSGWIYGRYLTTGKAAAAPAKPKTDAKNDSSTSRDQRRPALGNAATRTTSGLNMRTAPSPSGQVINQLASGAGVQVTGEVHGNWVQIRANGYTGWAYRTHLTGNVPAAQPIKHAEPTKPSTPAKPRTPAKDDAPIHTTSDVNVRTAPSPTAKAITALAQGTGARPTGEVHGNWVQIRANGYTGWAYRTHLTGNVPATKVDTPSRNTHRGSGTSRNKARPPRQDSSNGDSGKGSGHIAGRCIASFYDEPQTTASGEQFNPNAMTAANKTLPLGTRIRVTNVRNGRSTVVRINDRGPYVAGRCVDLSRASFARIADIGQGTAPITYTILAELNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQX4</accession>
    <name>W4TQX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70644">
        <property type="protein sequence ID" value="GAE70644"/>
        <property type="gene ID" value="JCM18909_4008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5852" checksum="7D836FEC910E849B" modified="2014-03-19" version="1">MESMNMRQLTSAVGETVGVWIGLSVYSQLEHAHLGLMYWIALTALAALSLRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE81</accession>
    <name>W4TE81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67275">
        <property type="protein sequence ID" value="GAE67275"/>
        <property type="gene ID" value="JCM18909_321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7926" checksum="57BA583EF1538335" modified="2014-03-19" version="1">MSSQTLSKTWKSIWWIPFTKGILAIVAAVVALLWSRQTMTALVIIVGIYAIIDSVMTLVNAQTLHAWPAPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF05</accession>
    <name>W4TF05_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Corrinoid ABC transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67540">
        <property type="protein sequence ID" value="GAE67540"/>
        <property type="gene ID" value="JCM18909_606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="22631" checksum="B4B374B3FCDB3A6F" modified="2014-03-19" version="1">MVPAAAFLGGLLVTSVIYALARPRAGSGTARLLLVGIAIGSAAAAVTGFLTYAADDDELQTVVFWQMGSLGHLDWIKLAVAAPVIIGCCIVLTLLARHLDLLSLGDRQARHLGLDVARTRKIIIAMTALLTGTSVAFTGTIGFIGLVVPHLARLLCGPSHRRVLPVSAVLGALLIVFADTLSRTIAPPDEVPIGLFTAALGAPFFLIVVLRTKEAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF84</accession>
    <name>W4TF84_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding protein Irp6C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67630">
        <property type="protein sequence ID" value="GAE67630"/>
        <property type="gene ID" value="JCM18909_703"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5359" checksum="C385E56E672AC7A1" modified="2014-03-19" version="1">MNVRLSNLHLSYGQRHVLDGVSLGPLERGTVTGLLGPNGAGKSTFIKRSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFJ1</accession>
    <name>W4TFJ1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Histidinol dehydrogenase</fullName>
            <shortName evidence="10">HDH</shortName>
            <ecNumber evidence="5 10">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hisD</name>
        <name evidence="17" type="ORF">JCM18909_343</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10 11 16">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="5 10"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67297">
        <property type="protein sequence ID" value="GAE67297"/>
        <property type="gene ID" value="JCM18909_343"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 14 15">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GAE67297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="439" mass="46240" checksum="C1F12CD4D8C6FB01" modified="2014-03-19" version="1">MLRIVDVTSETTDDLRCAVPRADFDVDAAMAAVIPVCSAVRDRGVEALREYSEKFDHVVPEHLRVPVEALARAAANLDGTLRRAFSESIRRRRQVCQEAEVETSFQPVEVAGGAWVSQRIVPVGRVGLYVPGGFAPLASSVIMNVVPAQEAGVSSIAVASPPQAECGGLPHLNILALCHLLGVNEVYAVGGAQAIAMFAYGVEGSDEADACPRVDMVTGPGNIYVVAAKRFLRGTVGIDSEAGPTEIAILADETADPRHIAADLMSQAEHDTLAAAVLVTDSTTLAEAVQRELAPMVSATLHSERIRTSLTSKQSAIVMVRDIDQGLEVVNAYAAEHLEIQTADAAAVAARVRNAGAIFVGPWAPVSLGDYSAGSTHVLPTAGAACHSSGLSVRSFMRAVHVIDYTEDALLELADSVEAFALAENLPGHANAITVRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFK0</accession>
    <name>W4TFK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67213">
        <property type="protein sequence ID" value="GAE67213"/>
        <property type="gene ID" value="JCM18909_257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="19908" checksum="01197B2A32F348F9" modified="2014-03-19" version="1">MENFNNDPFACIDHVGFAVKDMDEAIKYHCDVLGFRVLFREKNEGHGVEEAMLGTGKRGEESTVVQLLAPLSEDSTIGKYISKNKNMIQQVCYRTYNLDKTIATLKERGAVFTGEPSIGTAGSRVIFLHPSTPAVSSSRSPSLRPAACPTRTDVTPLRLTPGPVCLGPGVYFVPVSCTVVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFM1</accession>
    <name>W4TFM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67571">
        <property type="protein sequence ID" value="GAE67571"/>
        <property type="gene ID" value="JCM18909_642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="15888" checksum="EC6DE72A2C9AC484" modified="2014-03-19" version="1">MLHRLDEATINERAEGLLDALSLTSAADLLVCDYSAGMTKKIDLACAIIADPAVLVLDEPLESVDPLSGQTIRSILRRFVDGGGTVVISSHVMELVESLCDSVAVIAGGRLHAIGALDDVCQGKSLQNRFVELVGGNANMGEGLTWLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFM6</accession>
    <name>W4TFM6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Substrate-specific component CbrT of predicted cobalamin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67576">
        <property type="protein sequence ID" value="GAE67576"/>
        <property type="gene ID" value="JCM18909_647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20805" checksum="436FE65C7E751AB5" modified="2014-03-19" version="1">MSRRQHVAVRTSATSRILLIITAMMGLLAFCWPLFLNPGGAADYETRTPFLFAAILPVVLAVVVSQLSSDGIDVKALAMIGVLTACGAALRTISVNGRDLLRLHPHDCRGKGVRCGVRFRPRHHDNVRIRPAYRRFRAVAALPNDRLGVRRAGSGATPPGAGKSRNRLAMWLGIRVSLRLRVADGLRLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFT0</accession>
    <name>W4TFT0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67293">
        <property type="protein sequence ID" value="GAE67293"/>
        <property type="gene ID" value="JCM18909_339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9939" checksum="C1C49E9395B86538" modified="2014-03-19" version="1">MREHGYSDDAIQTLWDVMVPFAGYAFNKSHAAGYGLVSYWTAYLKANYPAEYGAALLTSVGDDKDKMAMYLADMRAQHINVLPPDVNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG07</accession>
    <name>W4TG07_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67721">
        <property type="protein sequence ID" value="GAE67721"/>
        <property type="gene ID" value="JCM18909_800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="7">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="8">
        <location>
            <begin position="78"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="174" mass="19484" checksum="6C10212257AF5F0E" modified="2014-03-19" version="1">MVQRCRTLVVPLFFVGDFLHEFGPDALRYFIAVAGPENQDTDFTWEEFVRRVNFELANEWGNLVNRSISMAFKNCHEIPAAGELTDADRELLDAAAAGFDTVGELLAHARFKAAITEAMRIVGLANAYISAEEPWKLKDNPERRDTVLHVALQVVSDVNTMMTPFFASFGAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG13</accession>
    <name>W4TG13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67373">
        <property type="protein sequence ID" value="GAE67373"/>
        <property type="gene ID" value="JCM18909_423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17530" checksum="9F26EDCE965E4E24" modified="2014-03-19" version="1">MCDTDLLTTLPAREVRSGLAEIVKCGFIGDPVILDVISNHPRLALDVTSQTFVEVLTRAITVKAGVVSADPHERTSSREEVGRERLNYGHTLAHAIEVHKHFTWRHGEADAVGMVFAAELSHRYLDYPMRSLRAPALSCLGSDCLLPVTRLSGQICARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG21</accession>
    <name>W4TG21_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67736">
        <property type="protein sequence ID" value="GAE67736"/>
        <property type="gene ID" value="JCM18909_816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_dim" evidence="1">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13615" checksum="A418FF431DA8AE29" modified="2014-03-19" version="1">MGVTQTDVDFGKVQARSTRLDLSTNPRAKMQGLHDGFVKLFCRPATGNIIGGVVVSPRASELIHPISVAVAERIPVDAFQHDFTVYPSIGISFGGGTPVADLRRVNAPIAPGCEYPGRLEIVEEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG29</accession>
    <name>W4TG29_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67099">
        <property type="protein sequence ID" value="GAE67099"/>
        <property type="gene ID" value="JCM18909_136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="284" mass="29220" checksum="E383C5F14168D85C" modified="2014-03-19" version="1">MTDDRTSSKAQRTVIIVGVDGSEDGLRAARYAAGSAIKRDADLIVLHAVDDAAVAGAWGVVYDPTALQDAGQVVVDDAIHVATERGMDPDRISGEVVLGNPAAILADRSADVQLVVLGRRATSGLERMFVGSTSVAVAGMSAAPVVVISRASTPDPTGGKKCVAVAVGPQSVGTAAVGFGFAEADHRGCKLLAVTVPGNDSEEVHDEALKRLNEVVKPLANEHPHVEVETRVLSGEPVDALVDLSGSVDLLVIGMKKHPILGWTAGGVSRGIMAHAQSPLAICH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG50</accession>
    <name>W4TG50_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67124">
        <property type="protein sequence ID" value="GAE67124"/>
        <property type="gene ID" value="JCM18909_163"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="313" mass="34354" checksum="14061107D9770242" modified="2014-03-19" version="1">MLDDVAESGKVGRISGLGWGMGYLGGIIALLVIYIAWIKPKVGWFGVTNHEGMNIRVAMLFCAVWILVLTLPTFCVLRDNPRPIESSEPRPHGLRALGHSYAELWRSVVRIWHVSRNTIIFLIASALFRDGLNGVFQFGGPLARQTFGFSASGVLIFGIVANFIAGISTILLGRLDDRIGPRRLIIFFTDRVVSVRYGCFHRPRWFCHGVLGTRPHHVWFRRTSSVRVAKLLTQICPPGYQGEVFGLYATTGKAVSFLAPALFGLFVTVGHAITGGDNNQYWGIIGIVLVLLAGLAATIPVSTAEIRGKTHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG73</accession>
    <name>W4TG73_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67950">
        <property type="protein sequence ID" value="GAE67950"/>
        <property type="gene ID" value="JCM18909_1052"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="10543" checksum="9C164D5F8B206E09" modified="2014-03-19" version="1">MQENGMQNTGHAVADSGFAFGAGCALDVPTPTPLSGPVVSTTSTPGDAGDPAPVPIEPTSGHMRCGDKVIDVGVGKRSGAEVWVSPREIRDFLLGGRRASLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC4</accession>
    <name>W4TGC4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_1111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the four-carbon acid sugar kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68005">
        <property type="protein sequence ID" value="GAE68005"/>
        <property type="gene ID" value="JCM18909_1111"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037051">
        <property type="entry name" value="4-carb_acid_sugar_kinase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010737">
        <property type="entry name" value="DUF1537"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031475">
        <property type="entry name" value="NBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042213">
        <property type="entry name" value="NBD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17042">
        <property type="entry name" value="NBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07005">
        <property type="entry name" value="SBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SBD_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="NBD_C" evidence="8">
        <location>
            <begin position="253"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="423" mass="44611" checksum="7B692F8E8CCE9277" modified="2014-03-19" version="1">MSEILVIGDDLTGTNATASAYARDGLRAVTVLDPTAPVDLDDSIQVIACSTGSRHMTPARAAQTVDAIVRNFGYDVRAIVKRFDTTLRGNIGAEIEATLTAARAMHPERRICGLVVPGFPAAHRTTVGGYQLLDGEPILMGPASRDPFTPVRHSGVAGIIHEQTQLTTTNIGLDVVMGDTSTLADRLTRAAQDAELVIVDSVTDDDQQRIATAASALESDERSWVVFESGPFGATYAHALGIRPHVDRANPILALIGSPTELTKLQSDRLESQSGVDLITVDDPASDVSQLLSRLRASAEVGKTVIGIRTTSRDGSAPDPLHASQMLALIIDLAVEYADSMQFDGIYASGGDVAFAVLDALGARGYEAENEVVPLAVSGKLVGGPHDGLGFATKGGLVGDADEAVECINQLRSRIRQSEPRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG7</accession>
    <name>W4TGG7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiol:disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68050">
        <property type="protein sequence ID" value="GAE68050"/>
        <property type="gene ID" value="JCM18909_1158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849074" evidence="4">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="43"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18185" checksum="9F9356546B884859" modified="2014-03-19" version="1">MKTRLIATLAAAALMVTGVSACSSTSASDDKGFAAGDGSWSKLPADKREPAAVLTGTDLNGKKISTADAKGKVIVVNVWGSWCAPCRHEAPALVKAADSTKNVAAFYGINTRDLDPGPPQAFSRAFHISYPSFYDPDGALLFKFTELLPKRFRPPSSSIARAARPPDSWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGN7</accession>
    <name>W4TGN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67319">
        <property type="protein sequence ID" value="GAE67319"/>
        <property type="gene ID" value="JCM18909_366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17790" checksum="3BABB5DF104A8D35" modified="2014-03-19" version="1">MGADEFLGDALRTHHLVPVAIAVTHGHIDHIGSARQVGDEYGIPVLCPRDDRHLLSDPMAGLSDFARPLIEQWYGSTTLREPEEVVDVEPFSHHQFANLDLEFLHAPGHAPGCSMIRTIDAEFGPIVMSGDVVFLPDLSDVLTCQAATLPDVTQPLRRRVAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY2</accession>
    <name>W4TGY2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine-uridine preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67792">
        <property type="protein sequence ID" value="GAE67792"/>
        <property type="gene ID" value="JCM18909_875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="10"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="321" mass="34341" checksum="9D2D6D3F2A6D9F5C" modified="2014-03-19" version="1">MPTSTRSLPVLLDCDPGIDDAFALAYLACRDDVETVGVVTTAGNVGQDDVLRNALGLTDLLGMDVPVARGADVPLVEPLMTAEETHGPHGLGHAVLRECGRHPDSRSGAQLWVDLARQYPGKLVGIVTGPLTNLALALREEPELPRLLRGLHVMGGAINHRGNTGPTSEWNIAVDPEAGHEVFKAWGEASQRVVLGALQATEVIRLDEGDRQAVQGLGEHPVVQVLTDALKFYFEFHQADGLGWCAYLHDPLVVANAVTGRFASTRPLAVDVELTGTLTRGQTVGDELGRWGKEPNVDLLCDVDAEGFIEHLLTTLRTGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH12</accession>
    <name>W4TH12_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68260">
        <property type="protein sequence ID" value="GAE68260"/>
        <property type="gene ID" value="JCM18909_1384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046264">
        <property type="entry name" value="DUF6297"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19814">
        <property type="entry name" value="DUF6297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850748" evidence="3">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18353" checksum="6140B7423CAB0360" modified="2014-03-19" version="1">MRCLPFTTSQVISVASVVPAVAAALWAIAVIPAFHGVGSAVSRPWEQAVMYGLVTAAGGLAGAIRWVSAKPADYSSPMVATQAGAMPPGLMFNLIRGLDMVALITIPLVLGWSPWVSVFIAVVVFGFLRMGGMNQQDLAEMREESQRQLAEARQDTRGGKAEKKVIERKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH28</accession>
    <name>W4TH28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68275">
        <property type="protein sequence ID" value="GAE68275"/>
        <property type="gene ID" value="JCM18909_1399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="3">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="2">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="26868" checksum="7B3090DA6AE15584" modified="2014-03-19" version="1">MPVAEGMVVKTQVSSEMARKAQKGMLEFLLINHPLDCPICDKGGECPLQNQAMANGRGESRYDGVKRTYPKPINISAQVLLDRERCVLCQRCTRFADQIAGDPFINLQERGAVSQIGAYQGDDFNSYFSGNVIQICPVGALTSAEYRFRSRPFDLVSTVTTCEHCAAGCQLRTDHRHYEVKRRNAGNLPDVNEEWNCDKGRFAFRYGRGDDRVTTPLVRHNGVLEPASWLRPCRRPPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH47</accession>
    <name>W4TH47_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor of DnaK operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67852">
        <property type="protein sequence ID" value="GAE67852"/>
        <property type="gene ID" value="JCM18909_942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="17216" checksum="0FC1E243D374C13B" modified="2014-03-19" version="1">MVRRSRNLSDAVDLAVIDKDAAIFVISVAAELAGMHPQTLRTYDRLGLVVPERTRGRGRRYSMRDVAALRMVQHLSQEEGINLNGIRRILQMERRIEQLSEQVDGLTDTVRGMQVARYQGSEDPRVFTAESTGRVHMGRTVVHAQLALPSHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH81</accession>
    <name>W4TH81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67489">
        <property type="protein sequence ID" value="GAE67489"/>
        <property type="gene ID" value="JCM18909_551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9216" checksum="B5D2EEF86360C297" modified="2014-03-19" version="1">MRRNNDCDYPFRPNTAFAYYSGLGTDREPNAVLVVDTTAETRDVLYFKPRAPRTDREFYADPPTAKCGLASESPLRKWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB5</accession>
    <name>W4THB5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68181">
        <property type="protein sequence ID" value="GAE68181"/>
        <property type="gene ID" value="JCM18909_1301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="23719" checksum="6EBB960D9D8119FE" modified="2014-03-19" version="1">MLAALSHVVSTAYDQKTITAVKATLVKRLDADRQTDGWGWPDHGANARATTRVAPGLYRAGDAIHRDQAVKGQAWLAAQQQADGSFANDWGPSWRALATAQAVPVLRGLQSLDTIGANPARVVTVDGWVPPRRLVQMTVLGDSYSAGNGTLVDGYPADGSYRSPKNYGSVLTRKLNREFGVDTTFQTDVRAWSGAQITTGDTILLVRPTEWIPTQRWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4THT3</accession>
    <name>W4THT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68077">
        <property type="protein sequence ID" value="GAE68077"/>
        <property type="gene ID" value="JCM18909_1189"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_3_C" evidence="3">
        <location>
            <begin position="269"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="477" mass="51924" checksum="AA056D80B9324951" modified="2014-03-19" version="1">MAQACTWNPSLIKKGARATACEVASTGIHWTFSPVLCVARDTRWGARRRNFRRGPLLIGEMGQAMSDGYQGSGPEDPNAILACAKHFIAYSQTQGGRDASEADLTPRTLRAWFAPPFERLARNKVATFMLGYQAIDGVPITINRPLIDDLLKREWGFNGLLVTDWDNVGRMVWEQKIFPSHTQAAAAAINAGIDMAMATPQFHSAALEALNTGLVSIDTIDHAVRRILTLKFTMGLFENPRRPDQQRQHTVIASSTHCELNLQLARQSLVLLANDGHLPLNPTSKHPLRIALLGPNCDNPDAQLGDWARNSGQGMRFTGHPDDVETVAQGMKTLLPDGWQLSVRPACDITTAAPDLEGCPLPDGQPRPTIVSPAAADPEAMDTAFQAVDDADVAIMVVGDDIHLTGEGRSTATLELIGPQKQLLEQTIASGTPTIVVVLSSKPLVLPRCIDHAAALVQAFNLATRRPRHRRTHPRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU4</accession>
    <name>W4THU4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein CrgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crgA</name>
        <name evidence="4" type="ORF">JCM18909_1485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CrgA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68356">
        <property type="protein sequence ID" value="GAE68356"/>
        <property type="gene ID" value="JCM18909_1485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00631">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009619">
        <property type="entry name" value="CrgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06781">
        <property type="entry name" value="CrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4570" checksum="54C2C397F2251DCE" modified="2014-03-19" version="1">MWLIVYYIAGNQIPGISDLGDWNILIGMGLMAAGFGVATLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW6</accession>
    <name>W4THW6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain heme biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67764">
        <property type="protein sequence ID" value="GAE67764"/>
        <property type="gene ID" value="JCM18909_847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14096" checksum="25F029EBB148CCCC" modified="2014-03-19" version="1">MTITEHPDHLIRPGSAPTGHPGGHPGGHPGHSPLVREIKHDLNNKPFIVIWEVTRACALVCQHCRAEAQHHAAPGQLTNAQGHELIDQLTSYERPYRCSSSPAVTVSSALTSSTSSSTPSARACTCRSRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW9</accession>
    <name>W4THW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68376">
        <property type="protein sequence ID" value="GAE68376"/>
        <property type="gene ID" value="JCM18909_1509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="11991" checksum="A96302ABD908E6F2" modified="2014-03-19" version="1">MSPDPLTPPAGALWVNNPYDYANNNPLTLTDPLGTHPVTDDQLAGLTHPVRHWWATHKDHILSWQFGLGVLAVGIGLTATGFGAGAGIGLITAATSGALISGGSTLAIEKNTPPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4THX8</accession>
    <name>W4THX8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-asscoiated permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67774">
        <property type="protein sequence ID" value="GAE67774"/>
        <property type="gene ID" value="JCM18909_857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="587" mass="63313" checksum="B456096CF2C95DCF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY3</accession>
    <name>W4THY3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67779">
        <property type="protein sequence ID" value="GAE67779"/>
        <property type="gene ID" value="JCM18909_862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15035" checksum="F009DE05836D9A97" modified="2014-03-19" version="1">MTDVEKSSTRGERILAAVVAFTLWMAVIFAIVAIFVGWRWSLRMFVGVLLIGIPGEIVMELVGRGPLLPSGASRIRRSRGSRLLLSALILIAWAFIVLAAIALIQPWYGATGDMAWVMVVGIAAILVQEGIDTRKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THZ3</accession>
    <name>W4THZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permeases of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68565">
        <property type="protein sequence ID" value="GAE68565"/>
        <property type="gene ID" value="JCM18909_1712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="340" mass="36696" checksum="88F16B2BD607762C" modified="2014-03-19" version="1">MGAMFGVSSVLGPLLGGWLTDSISWRWVFWINLPLGVVAWIACLFALKLPKHELAAKIDWLGLTFMDAGAVAIVLLATWGGSQYDWLSWQIIGLGVVTVVAWGLLPVVERRVEDPVLPLELFRNRTFVVSTIIGMLAMGAMFGVLAYLPTYMQMTYGYSATVSGLLLIPMTIGILLASTVTGLLTSRIGRYRIFIIIGPIVAAGGMVLMSTLNENSPVWRIMGDTFVLGLGMGMFFQLLVMAVQNDVRPTLLGTATSHNNFFRQIGVCLGASLIGVAFTTRLTNRVTDLFMSLAASKNPTVLKALGAMSSHHAAASLTPGAVNQMPDFVRNGIIEHTSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI56</accession>
    <name>W4TI56_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68640">
        <property type="protein sequence ID" value="GAE68640"/>
        <property type="gene ID" value="JCM18909_1790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14252" checksum="0E248DFC1506D51D" modified="2014-03-19" version="1">MEHDGNDVDAAFEALIAREFGEVVTAPGRPRPNGLPAQRAPAHVPQEPPRDADEMDEPLPMEPAAPPSPATKVGLVLVAICIVAVLLDMGGVNVPQTTLILAIASGGAGISLLIWRAITRGDRDDEDPWGNHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI71</accession>
    <name>W4TI71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67854">
        <property type="protein sequence ID" value="GAE67854"/>
        <property type="gene ID" value="JCM18909_944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="40" mass="4447" checksum="E29910C9B088AC23" modified="2014-03-19" version="1">MTEAMLAERFHAADRSIILEDIPIPHPGPGEVLVKVAYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB8</accession>
    <name>W4TIB8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67894">
        <property type="protein sequence ID" value="GAE67894"/>
        <property type="gene ID" value="JCM18909_986"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="192" mass="21561" checksum="F5BD3C1FAE3D154C" modified="2014-03-19" version="1">MADDPRLDPELLASGDRRNVIDRYRYWTMEAIVADLDAQRSRLHVAIQNWEHDFNIGSVVRTANAFNVAAVHILGRRRWNRRGAMVTDRYLHVYHHPDVPSFLHWLDEHGVTPVGVDNLPGSVPLETVQLPQDCCLVFGSEGPGLTDEVVKGCEQLVAITQYGSTRSMNAGAAAAIAMYAWTTQWRPEPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIM2</accession>
    <name>W4TIM2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67974">
        <property type="protein sequence ID" value="GAE67974"/>
        <property type="gene ID" value="JCM18909_1077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021365">
        <property type="entry name" value="DUF2891"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11199">
        <property type="entry name" value="DUF2891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18875" checksum="BD61F0BBF98A2A9C" modified="2014-03-19" version="1">MQWSAVTLLRCANQVIDHTIIDALTGVLNDRLTDENARVEAEYLRIHRGYERPYGWGWATLLAAQCAPLTGTTWASATRIISLQVFENLLAWLPTLTFPVRTGTHDNTAFGIGLCLDAARSLQRPEAIEAIVEHSHRLFDADADYPSSWEPSGNDFFVGGVERSPPHGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIM8</accession>
    <name>W4TIM8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68387">
        <property type="protein sequence ID" value="GAE68387"/>
        <property type="gene ID" value="JCM18909_1522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="235" mass="24699" checksum="23BD27E68DD4CDE3" modified="2014-03-19" version="1">MRIGLVVSYTENPREGSGWVGNAHGAQVAIWRLAQGSDDVEIQVVSDKGSERGAKDAIAQLKEAGVTGIVAAMSGPHTEVLAKEASRAGIPILLPYATKPNHAPDGAWFGIPAVSRQDNLIEAQAATLGCRRFATRGAELQAADTTDIPVDNKGQVTKQFVEKLAKDPKTCVYLKDLGPVVSPDTPTIVSDLRAGGVTVPIFLGPDATSAASTVPWCETVPSLTGSTRWECRLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS3</accession>
    <name>W4TIS3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68328">
        <property type="protein sequence ID" value="GAE68328"/>
        <property type="gene ID" value="JCM18909_1457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24369" checksum="6F0D78773FC0F678" modified="2014-03-19" version="1">MRCVPWLEPWKVIDLRTVVLRSNRVRSWWRVLLGPIVTSAAMTTVLSVVFMARHGFASHARGWSVLGVTVVSTWAWTVAGIALGLWLHVAVAAPIALATPLVWVIFPPGMSIYWLRHLTGSWIGCCTITQTLNPLVVTGTLCVELGLLVAAVVVVSARAAQHGRRLLLSLGGCVLVIGFIAGAVQVRHLDAFPTIDRELSVTCRTVEGVDVQLCLLPEHEAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV4</accession>
    <name>W4TIV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lysyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68353">
        <property type="protein sequence ID" value="GAE68353"/>
        <property type="gene ID" value="JCM18909_1482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="165" mass="17647" checksum="5C2164FE303E166F" modified="2014-03-19" version="1">MSSDTASSQSPDVSEQMQVRLDKRARIIADGGQAYPVDLLRDHTLVQVRQKYTDDTGELTLAPGEETTDEVTVGGRVVFVRNTGKLCFASLQDGFTETSNGERLQIMLSKAEVGDESLAAWKSDVDWVTMSGCVAGSSSLVVVSYPSWLLSGGWLQGSASAADPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX7</accession>
    <name>W4TIX7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68741">
        <property type="protein sequence ID" value="GAE68741"/>
        <property type="gene ID" value="JCM18909_1896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="254" mass="26899" checksum="317B1271129357BB" modified="2014-03-19" version="1">MDDHGLHGLPYGHFGEGCLHCRIDFPLEQPDGPRRYRSFVTEAAQLVARHGGSVSGEHGDGRARSALLDLMYSPDALTLFSKVKAILDPNNLFNPGILVNPAPVEANIRTHESALSPMTISHPEFAADVHRCTGVGKCIAHTAPSGVMCPSYQASGLEVDSTRGRASVLKEMVNGTLINGWNSPEVERALDLCMACKGCARDCPTGIDMASYRSTVLDEKNTVIASAPPLPPDDGAAAHVGTFAQSDPRSAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ01</accession>
    <name>W4TJ01_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Poly(3-hydroxyalkanoate) depolymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68771">
        <property type="protein sequence ID" value="GAE68771"/>
        <property type="gene ID" value="JCM18909_1928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="55"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="313" mass="34662" checksum="67A95EE78B4EB0C2" modified="2014-03-19" version="1">MSDDDEAGCSDGHGDKILDSSYDALTSVRELGKRPFRVAYDDGEGPDYNVKDPVVLLMAGAAASSDFWKPVVDRLQHVDVITYDRPGLGGTIWPGRYPELDEEVASLTDLVGLVQGHWDIGQPRKVILVAHSMAAFHAEAFARMHPEVVAGVVFVDPSVEWPTHPPRRRSVALPRAVYKVMDSMAGSLGRHAFAVGVMAQTMRSGSVVWHQFQEHRLHRVYGSPDAMAMAVAEWIGYDQQAWDLMAVRSQHAWPDVPTVLLSAVYSGQEQELKLHERLAPMLNARLVVVENSHHLMMLDRPEAIADAICSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ35</accession>
    <name>W4TJ35_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68413">
        <property type="protein sequence ID" value="GAE68413"/>
        <property type="gene ID" value="JCM18909_1548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="4625" checksum="B0BE15BEE17F1014" modified="2014-03-19" version="1">MFLSNSGTEANEAAIKICLARKKTDVSSPLIMPSMVVPSALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ36</accession>
    <name>W4TJ36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Arabinose operon protein AraL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68552">
        <property type="protein sequence ID" value="GAE68552"/>
        <property type="gene ID" value="JCM18909_1698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="236" mass="26100" checksum="10AC212EE9F04DE4" modified="2014-03-19" version="1">MSNNPTKDPDQYVDKLTRLGLPTAIEDISNTVVTTTRWLVNNHPDAKVFAIAEEPLKRSLREAGIELCEDPEKIDIVIASYDRTFDYRKLQIAFDAIWFHKRAFLIQTNSDRFCPFPGGRGEPDCAAVTAAIEACTGQQCKVSLGKPSPVMLTEALSGLDVDPTDCVMVGDRLQTDIQMALDTGMKSACVLTGEATADDVAALDAEHRPTWTLDRIDRLIPASAWRELGWTEDNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ69</accession>
    <name>W4TJ69_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-phospho-L-lactate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68587">
        <property type="protein sequence ID" value="GAE68587"/>
        <property type="gene ID" value="JCM18909_1734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="242" mass="26006" checksum="5C05C03703325B51" modified="2014-03-19" version="1">MAEVLQARFNGTGELAGHAIGNLLIAGLWQELGDPVSGLDMVGQLLDVRGRVLPMSLTPLDISAQVVGLDPNRPDEEYTLTGQATIAKTRAEVLKVGLEPSEPDACPQALEAIRASDNLVLGPGSWFTSVMPHLLVPQIVDAILESKARKILTLNVSGADETDGFSPARHLEVIAEHEPRMRFDVILVDRGFAGQDPHLEAFARNLGAEVVVDDLAMRDGSARHDPLRLASAYANIMGVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ92</accession>
    <name>W4TJ92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68856">
        <property type="protein sequence ID" value="GAE68856"/>
        <property type="gene ID" value="JCM18909_2021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="238" mass="25413" checksum="5F9592020A72C441" modified="2014-03-19" version="1">MHSATWLRRSRPVIHVLICLLLILAGAVGASFIQTGGGHIAVQGLKIPGKDGAVASADLFRPDTATATHKAPLIVVTPGFQRTKETQISYSLELARRGYVTLVVNPYNQGESTSQPPHSDDPSIQPAIDYVSRTNTLNYVDKTKIGITGHSAGGSQVRHMAAEYGAKEAKALKKATAPDSPGGTTITKEEREKKPNNSTPSALSYLGLVTAAQRQEAQKTSDPISASATPLRRRRLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJF9</accession>
    <name>W4TJF9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68677">
        <property type="protein sequence ID" value="GAE68677"/>
        <property type="gene ID" value="JCM18909_1828"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11351" checksum="F8953AFDB0C5CCB0" modified="2014-03-19" version="1">MLTIIGLSIDQRGLARIGFLLILLPLMAISVVAWFRPRVQTARSLAPVRIALGSQACETVTVERRGGLPLGAARFTDTIPAPLGSHDGRRPPSRPQSYLLHVVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI8</accession>
    <name>W4TJI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68707">
        <property type="protein sequence ID" value="GAE68707"/>
        <property type="gene ID" value="JCM18909_1858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="324" mass="36134" checksum="1D3150A3244BAE25" modified="2014-03-19" version="1">MTLTLEEVRKVRFPMVKRPGEGYRAIEVDDFVDKVEAAFMTLTDENERLKAQVEALRSGEPGGRPDQDLLNENEHLRAQVEELRSQQNGRSVNFGETDRAKSAQREAENRARQLEREKASLQSQVEELRQAIQRPGQNIDPAEVARLRSENERLGAQLRDAQALAARSRTSSVAQQPATTGDGVKKLVVTTSAEASPAVVRMVELALADAERVVHEAESEAGRKVQTAEAKARELTIDAQTRAERIESNARVNAEKLTSDAKSNADRVNADAQTRRTELFRELEAERDNLVGNVDHLRSFEASYREALTSHLRAQADNLDQGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK1</accession>
    <name>W4TJK1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">JCM18909_2324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TJK1"/>
    <dbReference type="EnsemblBacteria" id="GAE69135">
        <property type="protein sequence ID" value="GAE69135"/>
        <property type="gene ID" value="JCM18909_2324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8885" checksum="7BB0C4E527E8114B" modified="2014-03-19" version="1">MPKLSAAELRQLSGEELRNKVRELKEELFGLRFQSATGQLENTARLREVRKDIARVYTVLQERNLNIVDDPDSTKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJN2</accession>
    <name>W4TJN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68747">
        <property type="protein sequence ID" value="GAE68747"/>
        <property type="gene ID" value="JCM18909_1903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="40" mass="4551" checksum="23EF4EA21511E287" modified="2014-03-19" version="1">MTTSLKVRRGWWLKKYAYLLDEMFADENDQPGAAKGSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJP2</accession>
    <name>W4TJP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68996">
        <property type="protein sequence ID" value="GAE68996"/>
        <property type="gene ID" value="JCM18909_2175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="158" mass="16023" checksum="52ECBE43F6192906" modified="2014-03-19" version="1">MIKTAVVTGASSGIGAATARALADDGWHVICAARRVERIEPLSAEIGGQAVVCDVTSDESVANLVKTVGGKVDLLVNNAGGAVGQEPVTEADLDAWTTMYQTNVLGMGRVTKALLPALEIAEGTIVTITSTAAEWGYEGGAGYCAAKSGERAVVEACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ6</accession>
    <name>W4TJZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69121">
        <property type="protein sequence ID" value="GAE69121"/>
        <property type="gene ID" value="JCM18909_2309"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon_2" evidence="6">
        <location>
            <begin position="58"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22545" checksum="6AFCED28E502607B" modified="2014-03-19" version="1">MEDFNSFVSRFDWGNVSTGGPVFDVTKLDWLNGQYIRSLDAEVLTDRVLDYADQMGQARQVLGRDLTQEDRCAIHAAMPLVRERLTLLSEALPKLAFLLTDDDALVFDGDSVAKLKAGADDIQHAAVEVLKGLDDFSADAIQAALRARLCDEMGIKPRLAFAPVRVAVTGSWVSPPLFEAMEILGKESTLRRMQRFEAEIDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK30</accession>
    <name>W4TK30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-ornithine 4,5-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68479">
        <property type="protein sequence ID" value="GAE68479"/>
        <property type="gene ID" value="JCM18909_1620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028991">
        <property type="entry name" value="KamE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036843">
        <property type="entry name" value="KamE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16554">
        <property type="entry name" value="OAM_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="80"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19371" checksum="CAF90727EE7E2CE0" modified="2014-03-19" version="1">MNIPASEDIAREAAVEMASKMGITDPQVCNLQVLHPAEGCFVEVKGQATHVDVNPSKLTIPEKIELLPADELRQFVTDHELSVVAGTVGEDEHSVGLREILDIKHGGIEKYGVKYRYLGTSVPVEKMVDAAIESGADAILISTIISHNDIHRTMMRKLADLATEKASATRSFSSPAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK54</accession>
    <name>W4TK54_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69335">
        <property type="protein sequence ID" value="GAE69335"/>
        <property type="gene ID" value="JCM18909_2539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="10120" checksum="1B7B2DE5B8441C60" modified="2014-03-19" version="1">MVVNPDTTSPGVAVNVWYRVGSADEEAGHFGFAHLFEHLMFSARRAASHQANIWQRSSRWVGQQMRRPASTAPIISRPYRPERWNSHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK55</accession>
    <name>W4TK55_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68514">
        <property type="protein sequence ID" value="GAE68514"/>
        <property type="gene ID" value="JCM18909_1657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="197" mass="20162" checksum="D80EC8015D2659AD" modified="2014-03-19" version="1">MVIKMGEPVSSHDMVACHAETMRPDPNAPVVVAVDSFKGSLSSGKACRAVRRGFSAADPDREVITIPVADGGEGTVEAVLAAGCHAVTVKCHGATGDLAEVDYAMRDRHAVIEMATCCGLERADRVSGPPTPRRGLVASSRGLGEVIAAALRKGATDITVGVGGSASTDGGAGMLEALGVRLLDKKISRQFLPGQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK94</accession>
    <name>W4TK94_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FtsX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68927">
        <property type="protein sequence ID" value="GAE68927"/>
        <property type="gene ID" value="JCM18909_2102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="314"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="557" mass="60088" checksum="C99BB76472A7A58C" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKJ5</accession>
    <name>W4TKJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69465">
        <property type="protein sequence ID" value="GAE69465"/>
        <property type="gene ID" value="JCM18909_2683"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849284" evidence="2">
        <location>
            <begin position="26"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="143"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="283" mass="29892" checksum="5CDCEFD51AFD4AB7" modified="2014-03-19" version="1">MVTFVRGAILVFMAILSVQFGGAFAATLIPHVGALGTVALRMSLAALVLAPIVRPHVKGHSRADWTRVLALTIALAGMNTVFYFSLERLPLGVAVTAEFLGPLGMAAFGSRSLRDWLAILLALCGVVAVSGALTADWAHLDLLGLVFALVAGAFWALYAKSAQLVGMSWSKLEGLWWAILLSSVVLVPSGFATAGTRLVEPYHLFTGAVVAVMSSALPYSLEMYALRHIDTTIYGILTGAEPAIAAAAGFFILGQNLTRSQMLGMAFVVTAAWLVMAGGRQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW2</accession>
    <name>W4TKW2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="11" type="ORF">JCM18909_2358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TKW2"/>
    <dbReference type="EnsemblBacteria" id="GAE69167">
        <property type="protein sequence ID" value="GAE69167"/>
        <property type="gene ID" value="JCM18909_2358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="10">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="23229" checksum="FBF49B7DBD2C1725" modified="2014-03-19" version="1">MARYTGPLTKKSRRLGTDLVGNDKSFERRPYPPGVHGRGRTKDSEYSLQLREKQKARYAYGVLEKQFRRYYEEADRAQGKTGDVLLQILESRLDNVVYRAGLAATRRQARQMVSHGHFLVNGKKVNIPSYRVSTHDIIDVREKSKDLPPIVIARETFETRDVPAWLEVRPNKGRILVHQLPTRDQIVIDVNEQAIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY1</accession>
    <name>W4TKY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68819">
        <property type="protein sequence ID" value="GAE68819"/>
        <property type="gene ID" value="JCM18909_1983"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17818" checksum="4763CA8CFCF4BBA3" modified="2014-03-19" version="1">MPRYTTHPLFIALRAQPQYSGGMSKRRNRHSRGQRGPVVLPRSYGGRIDRVDPTHAEFFTACLTQAVQRVHMSCPGILDNVVVGAEDVPTMPDWTEGRVPLSSAVDGSEHTPAKIVIYRRPLELRTASRRGLAILVHRTLVEQLSALTGTPVETIDPSIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL58</accession>
    <name>W4TL58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sialic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69705">
        <property type="protein sequence ID" value="GAE69705"/>
        <property type="gene ID" value="JCM18909_2954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="452" mass="48374" checksum="4CAB4EC513E26FF6" modified="2014-03-19" version="1">MSTSTTPKQSALDLIDSRPLTRNQKNLVALAVVGNISEFFDIFLIGFVVSVLTKPWNLTGTEAGVILACSGLGTVIGAIMWGRLADKIGRRSSFFWCVLLFVVFTVVSVFTPDRGWIMLAILRIGVGIGVGGLNITSIPYVQEFVPAKQRGLLAGLASVFIPLGLFLGSLAQNALGDNWRALIALGAIPVFLLVWIRFVPESPRFLQSHGRDKEAREALAWALSMPADDIGDLPAVEHVQDASYSLVFGKYRKSLLIVSLGSFCFILGSFTIQSWGQTLLKTGFGKSPEQVGTLFMFVSLADLIGRFLSAWLADRIGRRATMLSFGLIGAGGTLIIALSARLGWGWQIFFVGVLIAMAFADGAFGILNAFGAEQFPNEARSTGLGLGYGIGATAKIIGPALMGLMVGGSAVKQNVTLDAVFPAFILFAVLLVIGGMTYMFARETRGTSLDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL76</accession>
    <name>W4TL76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Seryl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69282">
        <property type="protein sequence ID" value="GAE69282"/>
        <property type="gene ID" value="JCM18909_2482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="4492" checksum="66DEBA35F05E5118" modified="2014-03-19" version="1">MTRIIIMLLENHQQADGSVRIPEALRPYLGGREFIEPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL85</accession>
    <name>W4TL85_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69501">
        <property type="protein sequence ID" value="GAE69501"/>
        <property type="gene ID" value="JCM18909_2722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848803" evidence="1">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="18259" checksum="984F129E6A1EED9A" modified="2014-03-19" version="1">MAQFCNVSITLATFASAAVLLISITAPASASPSSPSDPPLLSATTAVRAQVTNPDTNRTYTPSSTASKVGLNASSGDPIVASYWTPERMKNAMPTETPTSTAEVDRQIDELKQQASANESLTDGSSPVAATSTTITPQAAPPVTNFSKPTEKSSTIIRPTARITCAPDPPLIATPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ2</accession>
    <name>W4TLJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane-associated zinc metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_3109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M50B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69850">
        <property type="protein sequence ID" value="GAE69850"/>
        <property type="gene ID" value="JCM18909_3109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="389" mass="41869" checksum="88D91B6A51F40775" modified="2014-03-19" version="1">MLAGIVFFGLIILSVLLHECGHFIPAKIFGVKVTEFFAGFGPKIWSFTRGETEYGFKWIPLGGYVRLIGMYPAKVHHRHSNRLTRLADEARVAEVEGITDADQGRLFSDKPVWQRLIIMSGGILTNLLLAFLLFWAVFGIHGRADQTTTVAAVTPCVHSAQTSGPCSTEDRRAPAAEAGVRAGDRIVSFNGRQVDSWSQLQEFIRGNGGGEVRLGVERDGAFVSLTPTHTLLTKVPDLSNPGRTVEAGYLGVSPTMVIVHSGPGDTVSQMWTMSKQSLSALARLPVLTWNVASDLVTGQARDANSPMSIVGASRVAGDVAGDSQLTLGDKIATGASLLGGLNLFFCFGSTSCHCRPWTVDISLEPSMRQVSGGYLNSPESLILARRTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL6</accession>
    <name>W4TLL6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69875">
        <property type="protein sequence ID" value="GAE69875"/>
        <property type="gene ID" value="JCM18909_3140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19336" checksum="B740E075D395D9E0" modified="2014-03-19" version="1">MATFIDIDDPADPRLADYVSLRDVNLRKSLEAEHGLFIAEGAKVIRRACEAGYPPRSFLLAPRWIDGLRDLFDGLDVEVFVVSETLAEQVTGFHVHRGALASMCRQTRWSAADLMAARRLVVCEDIVDHTNVGAIIRCAAGIGWDGVLLAPRAADPLYRRAIKTSMGTVFSVALGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP0</accession>
    <name>W4TLP0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69094">
        <property type="protein sequence ID" value="GAE69094"/>
        <property type="gene ID" value="JCM18909_2278"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850801" evidence="1">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="309" mass="32723" checksum="21CF5E5E85DBCF39" modified="2014-03-19" version="1">MILSAAALCVCASCTSTTPTTPSDEPSRTALVPSSKVTASVSPLDGIHTRAIINELVAASGNGPITKVDITKSALSITVQIGNSPTIWTWQNGKIDSSATQSAQTASRPFNPGDFAVEKLPVILSRAADISGSHMNQNLQIVEYNQGTVLMTVSTKPETQTVFFRPDGSAINHIDFASPSGMTEALSDAVAGAKQVDQISYQPGKAIIVDTPTTTPGIVMRRTRSADMPAWAVQRRGDASATFSPGLLNPHVIVRIMNLAAAQAHQKPSDMEWTISQDIKLDAPVLRVDINGVTRAFNTDGTDVTDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLP8</accession>
    <name>W4TLP8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69422">
        <property type="protein sequence ID" value="GAE69422"/>
        <property type="gene ID" value="JCM18909_2632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7045" checksum="4E6A82490BCD67A5" modified="2014-03-19" version="1">MTEVNGHEQEIPADSVVTAIGYLPEQDLRGAVEATGLPFNIIGDARKPANIMYAIWDAYEVAAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX5</accession>
    <name>W4TLX5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69522">
        <property type="protein sequence ID" value="GAE69522"/>
        <property type="gene ID" value="JCM18909_2747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7904" checksum="75FA8E11C7A6A559" modified="2014-03-19" version="1">MFPCSGVLARVVAPLAHSVVNKVTKEILEFLVLWWIYFTLMQPVSYAFGASVMVTIVTSAAGPQPLSPPSSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY6</accession>
    <name>W4TLY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrolipoamide succinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69985">
        <property type="protein sequence ID" value="GAE69985"/>
        <property type="gene ID" value="JCM18909_3261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxogl_dehyd_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22198" checksum="363086D946D5D746" modified="2014-03-19" version="1">MSPAPHDKSNNSPDFGANDWLIEEMRDQYQSDPNSIDPAWATFFRKEAVESTDSVTKSAASEQPAAKDVPGASAPKPATKPQPVPATKPAPITAKPQKQPPRLPMSADAPRHSAKLETVEPTVTKMKGAPMRTAKNMDQSLTMPTATTVRDVPMQLVIEQRTMINSFLKKGQRRQGFLYSHPGLCHGPGSQNSARHEQCICRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ5</accession>
    <name>W4TLZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-sulfur cluster assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69413">
        <property type="protein sequence ID" value="GAE69413"/>
        <property type="gene ID" value="JCM18909_2623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="182" mass="19848" checksum="30E7F7C21CB8EE75" modified="2014-03-19" version="1">MEWIDGNIGSKANMKYPACYLMGPHAKGEALSVAFAAEGQHQDTGAKMVHKAPYTSSTIVSKSISQGGGRSAYRGLVSVGKDAHHSSSAVRCDALLVDDISRSDTYPYNDIRTDEVSMAHEATVSKVSEDQLFYLMQRGLTEEEAMAMIVRGFIEPIAKELPMEYALELNRLIELQMEGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM03</accession>
    <name>W4TM03_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2,4-dienoyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69423">
        <property type="protein sequence ID" value="GAE69423"/>
        <property type="gene ID" value="JCM18909_2634"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="247" mass="27450" checksum="389B182A38EBE692" modified="2014-03-19" version="1">MPRGYLVDQFATEKFSHRTDKYGGSLENRLRFPREIVEAIHETVEDDFPVQIRFSPKSMMKDWNVGALPEEDFEEVGRDMPEGIEAARLLHSYGYQALDIDVGCYDAWFWNHPPMYQAKGLYLPYASELKEALPDIPLIVAGRMDDPDLAANAVSDGIVDMVSLARPTLADPDIVVKLQTDHPKRVRPCISCQEGCLGCIKYPVPNCSVNPEAGREAVTVEASNHIGGVVLAGSQPSFKEDDLALLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM27</accession>
    <name>W4TM27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70030">
        <property type="protein sequence ID" value="GAE70030"/>
        <property type="gene ID" value="JCM18909_3310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14019" checksum="546AFE9D002078C1" modified="2014-03-19" version="1">MARKNQLAFGDDVHTPAQAVQKYHLGGVLYFNWSGNISTPTNPAAVAHLSNGLQEAARTSSTAPLAIAVDQEGGIVARITSPATEFPGNMALGAVNDPRAARAQGAVLGRELAAWASTWTSPRTLTSTRTQPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM48</accession>
    <name>W4TM48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA gyrase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70055">
        <property type="protein sequence ID" value="GAE70055"/>
        <property type="gene ID" value="JCM18909_3339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="269" mass="28792" checksum="FD7F4B8D0B671888" modified="2014-03-19" version="1">MTLRSYDDAEYLLLATRKGMVKKTALKAYDSSRQAGVIAVNFRTEDDELIGAEQCSAADDVLLISRKGQAIRFSAGEDQLRPMGRATSGVTGMKFRGDDELLSMSIIHSDMPEDDRFVFTATGGGYAKRTAVSEYRQQGRGGVGIKAMALSEERGSLVGGLVVSEADEIIAIKTSGQITRSAVSEVPAKGRSTMGVKFVSVRGGDAVSIIAVNPEHTVEEEVADESVETVEGDATQVQSGDVVRRSDSVDEDRAVDTAENDMKPEDNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM80</accession>
    <name>W4TM80_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69299">
        <property type="protein sequence ID" value="GAE69299"/>
        <property type="gene ID" value="JCM18909_2499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="233" mass="24124" checksum="72C90C3D3EA4AB5A" modified="2014-03-19" version="1">MAIVATALNPALGPIAKIELIKAEIAAQATLLIRRGVHLQKAAIEHAIGRAFDAAVATAIISSPILSARIVTHLVRAGIDKSIAISLAPHIVKRLAKEPLLAFNTAKLVKDIAQQIVDIRNTKEAVAVYKQLKAELPTLDGLVQKACTPEPTPTPTPTPTPTPTPTPAPIPAPTPTHGATTPTHGATTPAHGATTIKPISRTTDRNNLGSHHTRIAAPALIHAKALPATGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA7</accession>
    <name>W4TMA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69324">
        <property type="protein sequence ID" value="GAE69324"/>
        <property type="gene ID" value="JCM18909_2526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="20193" checksum="F656733BB094D42C" modified="2014-03-19" version="1">MPQTGADCEVRRCIYHVPYPLDPNTTFGGQKRAVAMFKALTQWGEVWVVAGDARQRRRQIQVVMNAIRAGTRFEFCYSESSTMPTTLTEPHHLPTHPLEDFAFLTRLRRHGIPVGLFYRDVYWKFPLYGEGVPKAKQLVAQAMYRYDLLAYRQCLDVLFFCLHCVWGSGLTSVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG8</accession>
    <name>W4TMG8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1421 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70180">
        <property type="protein sequence ID" value="GAE70180"/>
        <property type="gene ID" value="JCM18909_3477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010820">
        <property type="entry name" value="DUF1421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07223">
        <property type="entry name" value="DUF1421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1421" evidence="3">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5935" checksum="E828FFF77A05850C" modified="2014-03-19" version="1">MARRDVVLLNTAAEGLQVDDGVVPQLAQRLERAAQSIDSGAVHDHLNRWIAATQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ0</accession>
    <name>W4TMJ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter associated permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69638">
        <property type="protein sequence ID" value="GAE69638"/>
        <property type="gene ID" value="JCM18909_2878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="255" mass="27167" checksum="3F9815544CD640D9" modified="2014-03-19" version="1">MPDAVNGHDLKALLGTTINVSYQRKTKASEAEAVPTKLKVVGLYDSSRPNNDGPDTVYVNVDDAKNWEAANAGMSPQAFDKQGVSRAYVEADSRAHVADVHRQLSQAGFSATSQADVVGYADQMTSDVQRMQTILIVVICVAALVLGVSVGSTISRQRGSQIAVFKAFGRSGEWILGCLETEAFLIGVVMALGIVVVGLVLCGVAITLTAAGVHLGPVAMTLVPLLDVLEQGAWFPLVLFLPRSRWDACRAPWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK2</accession>
    <name>W4TMK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69653">
        <property type="protein sequence ID" value="GAE69653"/>
        <property type="gene ID" value="JCM18909_2898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11275" checksum="71F0FEFB97869F78" modified="2014-03-19" version="1">MRHSAINLDVDACTSCMICARECPAWCITIDAHHEAVPDCDARRPRTVAVLDEFAIDWGLCMYCGMCIESCPFDALSWSGKRVSESSSRTDLVSAWGLDGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML3</accession>
    <name>W4TML3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="9" type="ORF">JCM18909_3528</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70230">
        <property type="protein sequence ID" value="GAE70230"/>
        <property type="gene ID" value="JCM18909_3528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="8">
        <location>
            <begin position="10"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="7">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="205" mass="23183" checksum="2D79BA337A5B5CF7" modified="2014-03-19" version="1">MANRSASLVEQALQLAREQDLDLVEVAPQARPPVVKLMDYGKFKYEAAQKARESRRNQANSIIKEMKLRPKIDDHDYETKKGHVLRFLKAGDKVKITIMFRGREQSRPELGVNLLRRLADDLTEYATVESPPKQEGRNMLMILAPTRKKNQAKADQKAERDRRAAERAEAAEADKAYEAAQRAAASTAKKKKKGPADNMDPDIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM8</accession>
    <name>W4TMM8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ORF">JCM18909_3234</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69961">
        <property type="protein sequence ID" value="GAE69961"/>
        <property type="gene ID" value="JCM18909_3234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE69961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7556" checksum="E9B3BBA0D2836B0C" modified="2014-03-19" version="1">MVPMLIGGSLNSLGYGLATLGPALGVAWIFAAVINGTARQPEAHKTMMTTAFIGFAVVEALALFGFVLAFIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR0</accession>
    <name>W4TMR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70270">
        <property type="protein sequence ID" value="GAE70270"/>
        <property type="gene ID" value="JCM18909_3574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10691" checksum="5B2F9CB80EFE3DD6" modified="2014-03-19" version="1">MRGSAGHARWVISQDWATQLGFDAAAPWRTGALDFTHQATASGHFINARCYTSETERRSVLDSGCTTTTNTARTLLATTPNASRRCTDWTRSQPDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY4</accession>
    <name>W4TMY4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UTP-glucose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69773">
        <property type="protein sequence ID" value="GAE69773"/>
        <property type="gene ID" value="JCM18909_3025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070569">
        <property type="term" value="F:uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="9959" checksum="65B128431E4F3B70" modified="2014-03-19" version="1">MTRTFTKKIGDFDDRIPEPPSLRRATSLKVKGDWTFGSEVVVAGDVSLDTEKPQTIPDGTVLTGEAPGAKKSDTGSTMLGGGGRGLDRTATYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ0</accession>
    <name>W4TMZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69559">
        <property type="protein sequence ID" value="GAE69559"/>
        <property type="gene ID" value="JCM18909_2788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11873" checksum="C8FC313910FFF042" modified="2014-03-19" version="1">MAVTLPALLFLLVIGFALGQWVTPDEIFGRKLLFDGVNLSVAIILFEGSLGLKLREVRDLGRPIFFGCAPSPQGWRGFLSPARRWYWGLTAAFPCCWARSSSSLAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN28</accession>
    <name>W4TN28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69609">
        <property type="protein sequence ID" value="GAE69609"/>
        <property type="gene ID" value="JCM18909_2846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8738" checksum="9D2A27EE47C6F98F" modified="2014-03-19" version="1">MIDAKAWKFVPTGQNLKGKPLDNPQRDTSKVDLGSASGVNYSGNLQGKANINIKDFAYQSTTRTIELTVGEKKISGKAPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN36</accession>
    <name>W4TN36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69828">
        <property type="protein sequence ID" value="GAE69828"/>
        <property type="gene ID" value="JCM18909_3084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="28457" checksum="AA4BC29847E5F708" modified="2014-03-19" version="1">MMSIILLTSPGGAPGLTTTALGLALTWPRDVVLVDADPCPGHVIESGYLMGRIPPRPGLIGLATAFRDGADPVQTMWEETIPLPHDSGDRMVRLLSGYGHLGQASLMGAAWSSLVSAMIDLGQAGVDVIVDAGRLGPEALPGSLVSRASLIGIVTGSRLRQLAGLSMRAEEAEAMSSTTTGTVGLVVVGPGRPYNSREIGHQFGLPVFGDVVFDAHAAAVLSDGEPAGKRWSRGRYVTSMQSMAESMRERIRRADQAITGPEILSTSAMGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN37</accession>
    <name>W4TN37_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70141">
        <property type="protein sequence ID" value="GAE70141"/>
        <property type="gene ID" value="JCM18909_3437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2" evidence="3">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="4">
        <location>
            <begin position="63"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="318" mass="34798" checksum="EEA625F3A3CBDE70" modified="2014-03-19" version="1">MTIFDAEGNVVAEGTGANAHARIPSVHLWQPGQGYLYEAEISLVNGDQVVDAYQQVFGVRTIRVDGARLLVNGEPVHLTGFGMHEDHQTIGKAHNDALMLRDAACLEWIGANSLRTSHYPYSERILDYADRHGLLVIDETPAVGINMGLGGGIFFGAQGYPTFSAETINDKTQEVHAQVIRDLIARDNNHPSVIIWSIANEPESETEAAENYFRPLFDVARAADPTRPVSFVNVMLAPFGKCRVSQYSDVLLLNRYYAGTSTLVTWPPLSVTGEKRWQVGLARTSRSSSPNTAPTPCPGCTKSPLSRGARSTRSRCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN55</accession>
    <name>W4TN55_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69639">
        <property type="protein sequence ID" value="GAE69639"/>
        <property type="gene ID" value="JCM18909_2880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6279" checksum="10FE3E37270BE348" modified="2014-03-19" version="1">MARSAELRPSFFVGPTCWRFDEDDGSSCTGGELECRHRRLLGGVLIGEERPSTGHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNC3</accession>
    <name>W4TNC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70450">
        <property type="protein sequence ID" value="GAE70450"/>
        <property type="gene ID" value="JCM18909_3776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="13893" checksum="7DB5C9A6B020AC80" modified="2014-03-19" version="1">MTGVILALVLLALISSAIGLRKVDVSPLGVRMRSQPQPVSWVQLAVGGAIVLLIIFSKTVLGFLGHQTGMVGVYVFIAVILAAVVELANIIGLKLLAMYFQHRLQRAKDATHLVAARQALENPRAAWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNI5</accession>
    <name>W4TNI5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69948">
        <property type="protein sequence ID" value="GAE69948"/>
        <property type="gene ID" value="JCM18909_3221"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6196" checksum="3B8AE1B323B7895A" modified="2014-03-19" version="1">MTVLRLHSWRCSSGSGQIPERVDGVVKHAASEPSGVRVLTTDVVAPQYDDDGPSGWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ0</accession>
    <name>W4TNJ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70525">
        <property type="protein sequence ID" value="GAE70525"/>
        <property type="gene ID" value="JCM18909_3858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13279" checksum="8FF7034646EC863C" modified="2014-03-19" version="1">MLLNRVNNRAYLLEKKHAFGRVVISEHSRGIECLVDILACSAVGAIYTPIDPQWPEARRKHIKTITNAAAIFTENTSHVTEAKAPLGVTFLERVDDPFNAPSYCFFSPRVAQVNRKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP89</accession>
    <name>W4TP89_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70531">
        <property type="protein sequence ID" value="GAE70531"/>
        <property type="gene ID" value="JCM18909_3869"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="7864" checksum="F3036C3F2FD3188A" modified="2014-03-19" version="1">MNSRTLLAIHGDAIYTSNVPPWALPVAQGGGDDGKDGRLRVKGVLPGPLKAPQTGSERAALSEQAEQAGLPEGATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPG4</accession>
    <name>W4TPG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt-precorrin-8x methylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70303">
        <property type="protein sequence ID" value="GAE70303"/>
        <property type="gene ID" value="JCM18909_3611"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10091" checksum="0777FAE355F8E2AC" modified="2014-03-19" version="1">MDLWAEEGKLDGAIVAIGNAPTALFRVLEVCEETDARPAAVVGIPVGFVGAAESKQALVDSKLGLEYLTLLGRRGGSAIAVAAVNAIASTDELTNSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPG7</accession>
    <name>W4TPG7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70621">
        <property type="protein sequence ID" value="GAE70621"/>
        <property type="gene ID" value="JCM18909_3976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="339" mass="36401" checksum="313363BA43146E0A" modified="2014-03-19" version="1">MTEAMNLPKVVLHDHLDGGLRPATVLELAAQRGLPMLAQTPEDLATWFFESADSGSLARYLDTFTETVGLMQDADSLRRIAREFVVDMATDGVIYAEARWAPQQHLTGGLSAAAATEAVQAGLVDGMESASRSGTTIIARQILCLMRHLDVPEDVVDLAVNHAPGVVGVDIAGPEDGFPLTPFTNALTRIQAAGIHLTVHAGEAAGPESVLDALNHGAERLGHGVRIIEDRDESEWGPIAQRVLSNQVPLEVCLTSNTQTGICRKVAEHPLSTLWSAGFNITVSCDNRLMSRTTTSREISLVSQALSWNRDDALAVQRNALQAAFCSQDDKQSLVPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPH6</accession>
    <name>W4TPH6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin biosynthesis protein CbiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70318">
        <property type="protein sequence ID" value="GAE70318"/>
        <property type="gene ID" value="JCM18909_3632"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_C" evidence="3">
        <location>
            <begin position="57"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TP_methylase" evidence="2">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="26560" checksum="445A0E1965BC5B6A" modified="2014-03-19" version="1">MLVVREQPWPLPPLPQNVTEDVETPAARIIVSERVAERVLADHGDDLPTVVLHPSCLVVGMGCNKGTEVESLRQLLVKTLEDNGLALGSVTRLVSHEVKAGELGLVKLANQLGVEYRTESAEALAAHDVPTPSDVVAREVGTPSVSEAAVLCQGAELLVHKTKTSEATCAIGRIPARGHLSVVGLGPGSRDLLTPRAVEAIRNATFVAGYAPYVRQIRDLVRPGATILATKMGTEEERTQAAIEPPGTAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK8</accession>
    <name>W4TPK8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH lacI-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3445</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70149">
        <property type="protein sequence ID" value="GAE70149"/>
        <property type="gene ID" value="JCM18909_3445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="15780" checksum="2EAF83154A7B2756" modified="2014-03-19" version="1">MGVGEESTAPVTISDVARAAGVAPSTVSRAFSRPGRVSVKTSERIFQAARKLGYRQDEVPRISTSRTYHLVAVCVADVMNPVFGATVKGVFAGARKCGYMVVLIDSNESSEIESETTKRSLATVDGFIFLSVRACRTPVCGTSPGSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPL0</accession>
    <name>W4TPL0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70442">
        <property type="protein sequence ID" value="GAE70442"/>
        <property type="gene ID" value="JCM18909_3762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6994" checksum="BA6E0C946FF811DD" modified="2014-03-19" version="1">MPVRCSCHHSDHPAWINVLGPILPDAITSPDLRACWEHVARRINAYRDLTGWTPQRHPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPR4</accession>
    <name>W4TPR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70512">
        <property type="protein sequence ID" value="GAE70512"/>
        <property type="gene ID" value="JCM18909_3842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7709" checksum="7F37900C291A5855" modified="2014-03-19" version="1">MFTDEELGKFGFKAYHIGDPVDGALLQADHPEYAELTPADLPGIKVFVDGRHVVDPAAWGDVEVIVVGDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPU9</accession>
    <name>W4TPU9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000052">
        <property type="protein sequence ID" value="GAE70557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70557">
        <property type="protein sequence ID" value="GAE70557"/>
        <property type="gene ID" value="JCM18909_3899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027624">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03604">
        <property type="entry name" value="TOMM_cyclo_SagD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="66"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="439" mass="48542" checksum="378CD500684C86D6" modified="2014-03-19" version="1">MTVERQPLRERARSLVSPYGLVSQVYPLHANEADPPFHVHLGRTGHSIHEGQITFEGDIGNTDGAGSGSDSTTAEFIAVMESLERYSSAMWDARSFLLESENNLQERFVSPNQFPRCSTAELDSGHVLRRYDPGVPIRWVRGWSLTSGHQVWVPAIAVYLHLPYLNDSERFIRSVSTGCAVHESMRKAVLNGLLEVVERDAIALTWLHELPLPRIAAGETGEFPPEALAGWKSYRDYGIETHLFDATTDFGIPVIFALQTSDQDDDIAQLVGAASALEPAEALTKVFREMASIRIALRAFLAQSTSIKIDSDVANVTGGAALMGQRAYRDAFSFLLNSERETSPSRMPNLLELNDDPLREMIIRIRLAGAEVIAVDITTDEARSVGARVVKVLVPEAVPLSFVHRERYLDTPRLISAPNSMGYLVDTAPTFNRNIQPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPZ3</accession>
    <name>W4TPZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70448">
        <property type="protein sequence ID" value="GAE70448"/>
        <property type="gene ID" value="JCM18909_3774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5832" checksum="AEF7D06CD361EBEB" modified="2014-03-19" version="1">MNKPFLVGLAVVASTIAVVSRISSVRRGWIDEVWRFGMDGIDERPDDEQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ20</accession>
    <name>W4TQ20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70478">
        <property type="protein sequence ID" value="GAE70478"/>
        <property type="gene ID" value="JCM18909_3805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="PTHR31047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20877" checksum="86116C722818FACF" modified="2014-03-19" version="1">MRALRQIREFCRVWDDEDLAERATKLADEIDAGVRQFGIVEDHLAYEVDGLGSVLEMDDANMPSLLSLPLTSDLGRDDPLYQSTRRWVLSAANPYLFSGPAARGIGSPHSPKGYIWHISLAVQGLTGDDAEARDCLETILATDGGTGWTHESFDPTDPTRFTRGWFSWSNSMACLLMMNVAGIDAIIGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ33</accession>
    <name>W4TQ33_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70493">
        <property type="protein sequence ID" value="GAE70493"/>
        <property type="gene ID" value="JCM18909_3820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017500">
        <property type="entry name" value="Phage_infect_YhgE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03061">
        <property type="entry name" value="pip_yhgE_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="289" mass="29805" checksum="1BBA0C7A4FD951F2" modified="2014-03-19" version="1">MMTERSHSTIRLRWPAVVVLVLVPLLVVAGLVGTTWHTTDRLGRVKAAVVNEDKAVKVRGQLVPMGRQLTAALMDSGSHTTDGHTVDWTLTDAQGAAEGLRDGTYSVVVTIPESFSADATSFSANDANKAKQALIDVTASQNSPVTDTTIAELTAQVARRSLNTTLTSKYLENVYVGFNRFAQQMARMAGAAAKLDDGATKLADGTKRSSAGAATLASGMTKLSGGAQQLSANGGKLTDGVSQLSGGLTTLSHKGQQLSQGADGLASGVATYTDGTGKVVDGIGQLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQA5</accession>
    <name>W4TQA5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70578">
        <property type="protein sequence ID" value="GAE70578"/>
        <property type="gene ID" value="JCM18909_3928"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="9998" checksum="7F27E4FC5879CA4E" modified="2014-03-19" version="1">MTANTGRNNAGEEILVFLVVGIGGIALLNKMVPKIIGNLGAWLRAHGLLDAPGQGLFDLGSLGSVSAAHLMIAVGVLIVVGALGSRLVGVGRRESQSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQT6</accession>
    <name>W4TQT6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lon-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S16.012"/>
    <dbReference type="EnsemblBacteria" id="GAE70599">
        <property type="protein sequence ID" value="GAE70599"/>
        <property type="gene ID" value="JCM18909_3949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="186"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="288"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="371" mass="38934" checksum="4A1F7097FDD1648B" modified="2014-03-19" version="1">MEKSSFAAANMTIMSEPTTPTSQAHDSGASANVIATVETEMRQTARFPTRWTAISSALVVLLCVLALILVPIPFVARSPGQTVNLFSTNERGKPMIQVDGLTTRHGEGEMRMTTVSITRADSRLSMAEALVAHLRADHDVLQREAIYPPGRSPQQVDADESYMMDTSERDAAVAALRAAGQPVTEMPMVSAVSAAGPAHGKLAPGDLIEKVDGKPVASVLDVGKAVRKHTVGDTVVFVVLRNSSVKTIAVTTVSSVSDRRAPAVGITIDTGYRYTPTITYNIPGDIVGPSAGLAMALSIYQMVAPNDLIGSLRIAGTGGISPDGNVVAIGGIQEKIAGAERDGAKIFLVPAGNCRDISGVETSMRLVKSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE77</accession>
    <name>W4TE77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DinG family ATP-dependent helicase YoaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67086">
        <property type="protein sequence ID" value="GAE67086"/>
        <property type="gene ID" value="JCM18909_121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HELICc2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7594" checksum="CB1E7EEE7A06CAC9" modified="2014-03-19" version="1">MTVSAGHAALLLAQGAGRLIRRADDRGVVAVLDPRLVTARYGNFLRASMPPFWTTTDREMAVGALRRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE85</accession>
    <name>W4TE85_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67096">
        <property type="protein sequence ID" value="GAE67096"/>
        <property type="gene ID" value="JCM18909_132"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13744" checksum="E654E969BDD01388" modified="2014-03-19" version="1">MTAAKAEWDKVVKLGHTNGFRNAQASVLAPTGTIGFMMDCDTTGIEPDFSLVKFKKMVGGGSMQIVNQTVPRALKNLGYTPEQAEKIVATSPTTVRSLVLLVLMRPTTRFSIAPWAPGSSPRWVTYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEN9</accession>
    <name>W4TEN9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNTP triphosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_16</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66987">
        <property type="protein sequence ID" value="GAE66987"/>
        <property type="gene ID" value="JCM18909_16"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="99"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE66987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="351" mass="37956" checksum="F9B61D0091009514" modified="2014-03-19" version="1">MVGHRGFDDIVHAHPSGTARIDIGEVVGREAREERENLLLRPGATRARGAGHRAVAEDPDPERTCFERDRDRIVHSTSFRRLAGKTQVVVHPTDHQRTRLTHALEVAQVARSIAAGIGANITLADAMALGHDCGHGPGGHASEQAFDAFIPEGFDHGPWGADVSLASLNLCAETLDGIRNHSWSRPAPGTVEGEVVSFADRIAYCAHDLEDAIKAGIVTVKELPQVVTEVAGTDRRTQLSVFIRCVIDTTCATGRVGMSADVAEALAALRAFNYERIYTRPESLGQAEAVIEVLHGLVAYYQGHIDQVPTEFLETDADRIHQVVAYVGGMTDQFAFFPCRRAVGMGPTPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF13</accession>
    <name>W4TF13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67550">
        <property type="protein sequence ID" value="GAE67550"/>
        <property type="gene ID" value="JCM18909_617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="228" mass="25418" checksum="AC5531E4F5088C8F" modified="2014-03-19" version="1">MELARFSATRLGKDVLDLNEVTVTVSSDELGERTLLDKVTWSIGPGDRIGLIGVNGAGKTTLLNLFDGSRKPDSGRVKHGKTLRLAHLRQEVDDLDSAMTVLESVNDVKARTKLATGRDASATDLLEGFGFTGQKLVTRIGDLSGGEQRRLQLLRLLMDEPNVLLLDEPTNDLDIDTLRLLEDYLDSWPGTLIVVSHDRWFLERVCDVVWASWEMARWPSSQEEFPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF50</accession>
    <name>W4TF50_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_459</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67401">
        <property type="protein sequence ID" value="GAE67401"/>
        <property type="gene ID" value="JCM18909_459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="232" mass="25824" checksum="2E56B07642856811" modified="2014-03-19" version="1">MTTPDHEPDSWAMQLVLLRDKHHPARQVDACEAAARAVVFLLDDPRTQPGGPWHDAVRQWSDKRIRKIVRRASGKRWDDVQVLDGVTISQDPPPYASPETGPARVRAFVPAPVHPQPKQIDKLQVAGTNLPADGDSTTIEPVVTIEINPRIEMTTGKACAQCGHAAQLAREAMSFGNDDDRHALETWRHDGFRVRVVTPTVEHWDSDVARVRVVDAGFTEFNGPTATTRARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFL9</accession>
    <name>W4TFL9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyruvate dehydrogenase E1 component beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67770">
        <property type="protein sequence ID" value="GAE67770"/>
        <property type="gene ID" value="JCM18909_853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4521" checksum="FCBBC1273E9CD243" modified="2014-03-19" version="1">MEAPVLRVTGWSTPYPPAKAEGEHIPDVDRILDAVDRSLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFN1</accession>
    <name>W4TFN1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67337">
        <property type="protein sequence ID" value="GAE67337"/>
        <property type="gene ID" value="JCM18909_384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8430" checksum="2182A66352AE6B48" modified="2014-03-19" version="1">MIRLPNKLYRFNESVLADFVTILKAIDDDPISVLELQRTLASDLHAEDLIDALTLLLTLDTLNLDASEGVIRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFR1</accession>
    <name>W4TFR1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67616">
        <property type="protein sequence ID" value="GAE67616"/>
        <property type="gene ID" value="JCM18909_689"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="209" mass="22096" checksum="CB3025B04BA22CFF" modified="2014-03-19" version="1">MPDEIVAALAKTGITDPFRIQIAAIPDAIAGRDVLGRASTGSGKTLAFGVPLLSRLSATPREDNRPRALILSPTRELAMQIADVLSPLASSMGLSTILIAGGMSYGPQTKAFKRGVDLVVATPGRLVDLLETGDADLSGVAVTVLDEADHMAELGFMEAVGSILDAIPADGQRLLFSATLDGAVNKLVRRYMHEPVTHEVDPDKDRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV0</accession>
    <name>W4TFV0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxine biosynthesis glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_34</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67004">
        <property type="protein sequence ID" value="GAE67004"/>
        <property type="gene ID" value="JCM18909_34"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SOR_SNZ" evidence="4">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="288" mass="31614" checksum="4610977A3541230C" modified="2014-03-19" version="1">MLKGGVIMDVVTPEQAKIAEDAGACAVMALERVPADIRAQGGVARMSDPDLIEGIIEAVSIPVMAKARIGHFVEAQVLESLKVDFIDESEVLSPADYANHIDKWAFGVPFVCGATNLGEALRRITEGAAMIRSKGEAGTGDVSEAVRHLRTIRAEMARLSSMSPDELYVAAKELQAPYDLVAEVARTGELPVVLFLSLGEWPLPPMPPWLCRWAPRASSWVRVSSSLVTRQLEPRLSLRRRPPTTIPTRLPRFPVVWARLWSVSMLLMCLPRTVWLSEVGEMAPLVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV7</accession>
    <name>W4TFV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_44</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67014">
        <property type="protein sequence ID" value="GAE67014"/>
        <property type="gene ID" value="JCM18909_44"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="2">
        <location>
            <begin position="60"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="23878" checksum="AFD94C81C69D21B7" modified="2014-03-19" version="1">MSTQHYSDGQDIGKGNEDAPMSNDEAARLIGQAIGQVQRVIVGQERMVEQLMVGVLAKGHILLEGVPGVAKTLAVRSFATVLGGSFARVQFTPDLVPSDIVGTRIYSASKETFDIELGPVFVNFVLADEINRAPAKVQSAMLELMAERQVSIAGQTFPAPHPFSVIATQNPVESEGVYPLPEAQRDRFLLKIDVPYPRGNEEFEILRRMSVKLPSLSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFW3</accession>
    <name>W4TFW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aromatic amino acid transport protein AroP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67860">
        <property type="protein sequence ID" value="GAE67860"/>
        <property type="gene ID" value="JCM18909_951"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="8">
        <location>
            <begin position="16"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="419" mass="44849" checksum="FF138694DDDFD1F1" modified="2014-03-19" version="1">MTEPDQQLHRSLRNRHIQLIALGGAIGTGLFYGAADSIAAAGPAVIVSYLVGGVVIYLIMRALGEMSVHNPTSGAFSEYAHRWWGDLPGFISGWNYWFNYIFVSMAELSVVGIYINYWFPAVPRWVSAAVLLAIVTTVNLLHVRAYGEVEFWFAIIKVVAIIAMIVLGVWIIFFGTGSTPATGIGNLWCNDGFLPHGVTGMLAGIIVVMFSFGGTELIGITAGEAEDPQRSIPRAINRVVGRILLFYVGALIVMVAIVPWTKIDGNASPFVQIFDLVGIPGAAAILNLVVLTAAISAYNSGLYANGRMLHALAHQGDAPAFLGKVNKAGSPWAGVLLSSAVTAIAVVVVGLLPEQAFVYIMSIAMIAAIINWATIIITQMLFFVAVSTLNPAPSCVSRCREPPSPTGSCWPSWYSWSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ0</accession>
    <name>W4TFZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67427">
        <property type="protein sequence ID" value="GAE67427"/>
        <property type="gene ID" value="JCM18909_487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11807" checksum="B103824692361E46" modified="2014-03-19" version="1">MDGVSLVMPAGSVNVVVGASGSGKSTLLMCLAGLEAPTRGRVVHSDVDVYGLDDRRRAAWRLRTIGLVFQNSELVPELTLRDNIALPLELLGTGRRDALKRADHLARSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG10</accession>
    <name>W4TG10_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67074">
        <property type="protein sequence ID" value="GAE67074"/>
        <property type="gene ID" value="JCM18909_109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5520" checksum="92748CB2AE58B6D6" modified="2014-03-19" version="1">MLFLAPTGLVMATLQMLDIKYSHWLKFVWPLVVFVLVYGGILLALQAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG47</accession>
    <name>W4TG47_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protoporphyrinogen IX oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67766">
        <property type="protein sequence ID" value="GAE67766"/>
        <property type="gene ID" value="JCM18909_849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="247" mass="26723" checksum="18AD972EE6E91E5C" modified="2014-03-19" version="1">MEMPSGVTPVGPTKFLPTIASRILSPAGLLRAGLEPFNARPHPDDVSVGQFIAERFGDEVSRAIVDPLLGGIHAADLNTFSLAVAAPALERTVRKGDSIVAGTLKRNAARRWPRLRHHSQRSGPRTPATATWRHGLMTLPEALAQGLTIHTNTRATGIRQVGHEWVVDVTGPRGVGSVAVDDVIIATPARVAGACLLPHARRLPNCCRSVKALRLPRWLCRLTLLATRSPRPKRGSLVRHGLPWCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG66</accession>
    <name>W4TG66_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RcpC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67940">
        <property type="protein sequence ID" value="GAE67940"/>
        <property type="gene ID" value="JCM18909_1042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017592">
        <property type="entry name" value="Pilus_assmbl_Flp-typ_CpaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031571">
        <property type="entry name" value="RcpC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16976">
        <property type="entry name" value="RcpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03177">
        <property type="entry name" value="pilus_cpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="RcpC" evidence="3">
        <location>
            <begin position="108"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="242" mass="25895" checksum="436B821917366011" modified="2014-03-19" version="1">MNPRQRRGLIYLLIAVVVAIATFLTVTRYVASVNSQVGSRVTVYRAKTAISPYTPLSESVLEPVEVPRRWTSDSSMVSLSNLKGRRIGFRVEAGTVITRDMLIAPSDLNPDEREIAINVNSVTGVAGRVKPGDRVDIYAVFADVPGLPKSVRVLTRNVRVVSIAGKMNVTGQSGNGVTETEVIPVTLALTPNDATAVTYAAAFAKEVRLVALPTDTGANRNGEKNEYDASSLGGKAVPEGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG80</accession>
    <name>W4TG80_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tryptophanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67159">
        <property type="protein sequence ID" value="GAE67159"/>
        <property type="gene ID" value="JCM18909_201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amoino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018176">
        <property type="entry name" value="Tryptophanase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00853">
        <property type="entry name" value="BETA_ELIM_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="828"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_elim_lyase" evidence="11">
        <location>
            <begin position="103"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="10">
        <location>
            <begin position="564"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="936" mass="102320" checksum="CFEE230E273CE3E2" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE3</accession>
    <name>W4TGE3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YidE/YbjL duplication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67856">
        <property type="protein sequence ID" value="GAE67856"/>
        <property type="gene ID" value="JCM18909_947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6284" checksum="F03F972A5CED5324" modified="2014-03-19" version="1">MTVLTDFLATHQLLTILIVLASGALLGQIKFGPLRFGAAGACLWGWSSGPLILASVKTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI1</accession>
    <name>W4TGI1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68065">
        <property type="protein sequence ID" value="GAE68065"/>
        <property type="gene ID" value="JCM18909_1177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16110" checksum="27F46A9F836A1EF4" modified="2014-03-19" version="1">MTGRVSTFGWFLRSRGVVVVLVYLIAGVACARQLGGDLVAVPMSAGRSVDVGIGTSSLCGLIASVVFSSPDPQRERAFPDVPIRVMRVGWAVIVLVWPAVWVVLFNLGRSDSLRWVLLDQSPFDALSLAMSAVLVVVGLVLQWHTPGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK3</accession>
    <name>W4TGK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67901">
        <property type="protein sequence ID" value="GAE67901"/>
        <property type="gene ID" value="JCM18909_994"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18495" checksum="C19E34F83199D15A" modified="2014-03-19" version="1">MLAGLLDGCHRVLKVARIVQSVEHAEHVHAVFGRLLDKLVDDLVVVVAVAQKVLATQQHLQPGVRQQLAESTQTLPWVFVEESDARIEGSSTPAFNGPEACHINVGTGINHVLHGHASGKQALMRVAEHELGNANLSWTHESNLCTFPEAFTDLGSKFHALTVFSHEAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP1</accession>
    <name>W4TGP1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Isocitrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67702">
        <property type="protein sequence ID" value="GAE67702"/>
        <property type="gene ID" value="JCM18909_781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="370" mass="39955" checksum="E240A98591782688" modified="2014-03-19" version="1">MPTIVWTKIDEAPALASYSLLPIVEGFLDESGIDITTSDISLAGRILAQFPDRLNEDQKIADHLAELGELTSSPDANIIKLPNISASVPQLKAAIAELQSQGYELPDFPDKPSTDEEKDIAARYATVLGSAVNPVLRQGNSDRRAPAAVKAYAKAHPHRMGQWTDQVKARVAHMDHGDFFDHEESFVSRGQDLDVVLIRTDGSETTLAGGIKTLDGEIVDATFMSVDALDEFYASSLAQANEEDLLWSVHLKATMMKVSDPVLFGHAVRTFLVDVFEKYGDDLNSVGVNPDLGLGDLYTRLEKLPAERATAIKTAIDSAFAARPALAMVDSDNGITNCMPETSSSSTLPCQLSSVILDVCGTPKVSVKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR8</accession>
    <name>W4TGR8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67727">
        <property type="protein sequence ID" value="GAE67727"/>
        <property type="gene ID" value="JCM18909_807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4663" checksum="89521DDA09536072" modified="2014-03-19" version="1">MLVRRGLALCRAEPTLRSRAIVMGFQPMSMRRASTTVAALKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGW4</accession>
    <name>W4TGW4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67772">
        <property type="protein sequence ID" value="GAE67772"/>
        <property type="gene ID" value="JCM18909_855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="2">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="281" mass="29478" checksum="9176F229FF5CBF98" modified="2014-03-19" version="1">MDRTAHILAKPPARRLAADLGIDLSQVTGTGPQGAVTRSDVKAAAHDGAAAAGDAGASCGDAELANLSVMSRRLLGGAPTEPDGHTRKVPVRGVRKVTAKAVKESLDTKALVTAFLTCDVTPTMELVNRLRADRRFKGLRVSPLTVWCKAVCLAMGRTPIINAAWDDATDQIVFRDHINLGIAAATPRGLMVPVVRDAQDMTMLELATEITRIVAIAKEDKLQPPDYADGTFSITNVGVFGLDAGTPVVNRTESAILVLGALARRPWVVGTGETSALCPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH01</accession>
    <name>W4TH01_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate--glycerone phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.121</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1368</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone + phosphoenolpyruvate = dihydroxyacetone phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18381"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.7.1.121"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.121" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68245">
        <property type="protein sequence ID" value="GAE68245"/>
        <property type="gene ID" value="JCM18909_1368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047324">
        <property type="term" value="F:phosphoenolpyruvate-glycerone phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039643">
        <property type="entry name" value="DhaM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012844">
        <property type="entry name" value="DhaM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38594">
        <property type="entry name" value="PTHR38594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02364">
        <property type="entry name" value="dha_pts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="14390" checksum="DEEA4FC70B57E5E6" modified="2014-03-19" version="1">MADLASQMLPGPETPPIEVASGLDDTTLGTDATAVSAAIEKKVGNCDGILVLVDIGSALLSAEMALDLLDADIASKVKISTAPLVEGAVVAAVMASTGAELEVVAAEAEKKPWTRKSPSSPTIEPTRRWCPVRPGATVSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH16</accession>
    <name>W4TH16_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoserine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67827">
        <property type="protein sequence ID" value="GAE67827"/>
        <property type="gene ID" value="JCM18909_913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="39" mass="4258" checksum="69C9ED3756FA00A2" modified="2014-03-19" version="1">MFAIAGLPIAFCAKPVAVEAARNTIRCERIDAVRAVWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH40</accession>
    <name>W4TH40_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyribonucleotide nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68101">
        <property type="protein sequence ID" value="GAE68101"/>
        <property type="gene ID" value="JCM18909_1215"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10126" checksum="DF4241A04E8826BD" modified="2014-03-19" version="1">MINAIANPQMPEVGERYLGTVVKTTSFGAFVSLLPGKDGLLHISKMRALNDGKRVEAVEDVLSVGQKIQVEIAEVDDRGKLSLVLASDEDDADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH94</accession>
    <name>W4TH94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dipeptide transport ATP-binding protein DppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_888</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67803">
        <property type="protein sequence ID" value="GAE67803"/>
        <property type="gene ID" value="JCM18909_888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="oligo_HPY" evidence="5">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13739" checksum="A39DF09EC2433233" modified="2014-03-19" version="1">MTHDLGVVAGRADRVAVMYAGQIVEVASSTDIFINPQHQYTRSLIAALPEQTTDTREELYTIPGMPPDLREKIVGCAFATRCPLATEICTQSSPHMVTLAEPTRRAPTTNPPTMYIPASIRQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB4</accession>
    <name>W4THB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67534">
        <property type="protein sequence ID" value="GAE67534"/>
        <property type="gene ID" value="JCM18909_600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5235" checksum="1BDBB6E761D6B4E7" modified="2014-03-19" version="1">MAVVTTPQARAADGAQPAASTLTFRPAQPTGDDFGWCRHVVVGEGYGGCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4THG7</accession>
    <name>W4THG7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68400">
        <property type="protein sequence ID" value="GAE68400"/>
        <property type="gene ID" value="JCM18909_1535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="7">
        <location>
            <begin position="353"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="703" mass="76063" checksum="0A20A6372FDAD9B6" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4THP1</accession>
    <name>W4THP1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67933">
        <property type="protein sequence ID" value="GAE67933"/>
        <property type="gene ID" value="JCM18909_1034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14598" checksum="8F5240BB8B203062" modified="2014-03-19" version="1">MFLQFAGSGNGYKDIPTSEAVSIINSSKKLDSVTLTDGDQVIKITENENKKYRSYWVGNQSDQLVDRLNYRVKAKTLKSWQGENPGQSIWKALLINFLPFVIILLFFLVGHERGTGHGWPWWRHGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ0</accession>
    <name>W4THQ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II/IV secretion system ATP hydrolase TadA/VirB11/CpaF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67943">
        <property type="protein sequence ID" value="GAE67943"/>
        <property type="gene ID" value="JCM18909_1045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="49"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="397" mass="43770" checksum="A277BF2018BD617B" modified="2014-03-19" version="1">MSKLDTAQRRVRLERVIAHLVSREGVILSTSQRNQLVRRVVDEAVGLGVLEPILSDPSVSEIMINGHQTIYVERAGRLELWPTAFSSEEQLMQAIDRIVSTVNRRVDESSPMVDARLPPDSRMPRGARVNIVLPPLALNGPTVTIRLFPQALSLEAMVERKSLDMAMARLLQSFVQARLNIIVSGGTGSGKTTLLNALSTFIDPAERIITIEDAAELTLDQPHTIRLETRPANVEGGGQVTIRDLVRNSLRMRPDRIIVGECRGGEALDMLQAMNTGHEGSLTTVHANSPEDALVRLETLASMSDVDMPFQALHDQVNSAIDIIVQLQRTSYGARRVTTVSYVTSRRQEPFCIEPIMEWVHVPQNPREGSFHARGLSDPLRERLAASGVSVNHEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4THY8</accession>
    <name>W4THY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68137">
        <property type="protein sequence ID" value="GAE68137"/>
        <property type="gene ID" value="JCM18909_1255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="80"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16581" checksum="9A9702E4659BFD76" modified="2014-03-19" version="1">MSTVSLGRLARQLDIGPRIKLGRGEERTGGHDKTSILADTTEALLGAVELSAGLPDVLRLVHHLFDPLVDEADRSGAGTDWKTVLQEYCAEHGFDAPRYEIVGSGPDHNRRYCARANVDGRLHAAYTGHNKKEAEQGAARRAVSALMPSSHTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI20</accession>
    <name>W4TI20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport system permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67814">
        <property type="protein sequence ID" value="GAE67814"/>
        <property type="gene ID" value="JCM18909_899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849250" evidence="5">
        <location>
            <begin position="36"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29426" checksum="85BF0F79660D3E9A" modified="2014-03-19" version="1">MTKRIIQPLGAVLLAVLVVGIPLWTVVVTAGKSQAEALIPDMSLPHHWQLWTNVSTVTSQTRIGWAYLGSLFLLVPSVVVVLIIGSMASWVLARRKGKLVSVIYALGISGIILPPAVVTLVLLLRQLGLAGRPIGMICAYVGMYLSTVIFFVTGFVRTIPESLEEAARIDGAGPMRVFVTVILPPAATSTGNCDDSHQPVRVERRLLRLLCRRGRMDTLPLNLFTVASAGVHLNNWHLIFTYVLLMSVPIVVLFIVFQRSIISGITSGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI61</accession>
    <name>W4TI61_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68645">
        <property type="protein sequence ID" value="GAE68645"/>
        <property type="gene ID" value="JCM18909_1795"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="7"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23399" checksum="35830944F25699F7" modified="2014-03-19" version="1">MRITHLGHSCILVEAAGQRILVDPGNLSQSWRGLTDLDAILVTHRHPDHVDPEHIGALVDANSGAVVRAEEGACHEIPALDADPVAPGDVLQIGEVRIEAVGGHHAVIHRDLEPIGNVGYLIGEGLGTILYHPGDELDETPRGVDVLACPAHAPWAAMKETVDFARSVGARRGFLIHEGLLNERGWQLSFDRHQEMVPTTFHDLRDGQPWEVPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI92</accession>
    <name>W4TI92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68252">
        <property type="protein sequence ID" value="GAE68252"/>
        <property type="gene ID" value="JCM18909_1375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5822" checksum="D30F3707C45AC1C6" modified="2014-03-19" version="1">MRTIFASLTVPNYRIYFSGTLMANMGQWMARTAQSWLVLIILTHGNARCSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI98</accession>
    <name>W4TI98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68486">
        <property type="protein sequence ID" value="GAE68486"/>
        <property type="gene ID" value="JCM18909_1627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="260" mass="28491" checksum="C553E3223C77DB52" modified="2014-03-19" version="1">MGFLGGFQIAFFAFVGIELVGTAAAETKDPCTTLPKAINAIPVRLALFYVFALLAITAVIPWRKVVPGVSPFVSLFGLAGFGAAASVMNFVLLTAAASSDNSGLYSTSRMMYGLALDGQAPSRFRKLSSNNVPRNALVASCLLLLSGITFLYTSDSIMQAFALVTTVAALLFLFTWSLIVVCYIVYRRKRPQLHEESIYKMPGGVPMCWVVLAFFTISLVILTLDPTTRIAVLITPIWFAFIGSMYFVHHRHEQRKEALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIB9</accession>
    <name>W4TIB9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_1856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68705">
        <property type="protein sequence ID" value="GAE68705"/>
        <property type="gene ID" value="JCM18909_1856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="261" mass="27595" checksum="26935BAA9765313F" modified="2014-03-19" version="1">MLRFVIDPGANHGVGVAFTDRVDASGQGRGGAGFEGFNLGRTDEDPTVLEHVESLRSRLGLGPVMVCHQVHGNEVWRVGPDDVEGWISQRYLGDHVERQPSLPVADAMVTDLPGVALAIRVADCMPVMLADPKAGVVGAAHAGRVGFLAGVLPATVKTMRGMGATELLAWLGPHICGRCYEVPAEMAEQVWAKYPATRAVTRQGTPALDLGAGALAQLESLGVAAVGLDPCTFEGDDFFSHRRDHGAGRLAGLVWKAHDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC2</accession>
    <name>W4TIC2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit I</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoI</name>
        <name evidence="8" type="ORF">JCM18909_1406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68282">
        <property type="protein sequence ID" value="GAE68282"/>
        <property type="gene ID" value="JCM18909_1406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="200" mass="22624" checksum="61B8A6738EABA975" modified="2014-03-19" version="1">MMGAWSGFGITFETMFRKSFTQGYPEKGKEKPMPPRMHGRHQLNRWPDGLEKCVGCELCAWACPADAIYVEGADNTDEERYSPGERYGRVYEINYLRCILCGMCIEACPTRALTMTNDFKMADTSRAKHIWTKDELLAPLKEGMEQPPHPRRLGDDEDDYFNGLPPSGQDDVRTGPANSGATAHRDDDNDTQHKDEEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID2</accession>
    <name>W4TID2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68720">
        <property type="protein sequence ID" value="GAE68720"/>
        <property type="gene ID" value="JCM18909_1873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17288" checksum="1D78E17AF20A4351" modified="2014-03-19" version="1">MCWVVTGMADVIAITSYWSFWTHDRTWAFILTATTLLLLLALNLLTVKLFGELEFWFALIKIVAILTLIAVAIVLIVMGFTSASGYKAPVSNLWSYGGFAPRGWSGFFGGFQIAVFAYVGIELVGTTSAETANPPKTMPKAINAVPVRVLVFYVAALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII7</accession>
    <name>W4TII7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate-dihydroxyacetone phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68248">
        <property type="protein sequence ID" value="GAE68248"/>
        <property type="gene ID" value="JCM18909_1371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="296" mass="30809" checksum="5B8196DBE190F6AB" modified="2014-03-19" version="1">MKKLINAVEDVVVDSLRGVAAAHPHCLKVDLDHRIVLRASGPVNGKVGLVSGGGSGHEPLHSGYVGRGMLDAACCGEVFTSPVPDQITEATKAVDGGVGVLHIVKNYTGDVMNFDMAAEMASMEAGTRVESVVIADDVAVQDSLYTAGRRGVGLTVLAEKILGAAAEDKRDLDTLLELAQRINDGGRSFGVALTSCTVPAAGKPTFDLDENTMELGVGIHGEPGRETATLGTAAEVAAQIVEPILLTMTSPQPRSLPCLTAWAAPLSSSSTSCGVKSPRFWQERASRLPAPWSAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIX2</accession>
    <name>W4TIX2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="11" type="ORF">JCM18909_1891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68736">
        <property type="protein sequence ID" value="GAE68736"/>
        <property type="gene ID" value="JCM18909_1891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="324"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Arm" evidence="7">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="561" mass="61993" checksum="BE9250D384B320CD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY7</accession>
    <name>W4TIY7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68119">
        <property type="protein sequence ID" value="GAE68119"/>
        <property type="gene ID" value="JCM18909_1236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8112" checksum="76A1BA3FE93D7488" modified="2014-03-19" version="1">MIGVGRSEGEILCDISDETQLESLWQQAGHSALGTTPFAPLEELTSADFNDAWKNKALSQINLVRTGINHISER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ57</accession>
    <name>W4TJ57_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68980">
        <property type="protein sequence ID" value="GAE68980"/>
        <property type="gene ID" value="JCM18909_2158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="123"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="222" mass="24456" checksum="6B382BBDAEB5E2C8" modified="2014-03-19" version="1">MRESYHDELNATSGRILMMAELVRVAVKDATAALIGADLTTAERVISDDSKVDSLNEEIERRCFDLLARQAPVAGELRTIVAMLRMCYELARMGDLAAHVAKIARLRFPEVAVPPQVADQFVEMSKIADSMIGKAEKTLADRDAEAAESLASEDSKMDDLRRDQFRLLLGDDWTYGVESAVDTALLGRYYERIADHAVAVGSRVIYIVTGEGPAGEDWPSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ74</accession>
    <name>W4TJ74_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68592">
        <property type="protein sequence ID" value="GAE68592"/>
        <property type="gene ID" value="JCM18909_1739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6002" checksum="08B614FC3058B275" modified="2014-03-19" version="1">MFCLDATWVRIEEAGMAVMTQPVLLEESNRKHAGALCLLCHSRMLDIVILCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJG8</accession>
    <name>W4TJG8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68299">
        <property type="protein sequence ID" value="GAE68299"/>
        <property type="gene ID" value="JCM18909_1427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18760" checksum="33935D0256B825AD" modified="2014-03-19" version="1">MLVWTTLLLHSGFTDPSAWSEATRQGLRILVFVLPGALASAAIDPTRLGDALAQQTHLPQRPVVASMAGVVRMGHLGDQWHIQSDVRNLRGLGPKRSLSSRITYLSSMTFAMVLYAMRSSEVLSRAMDSRGFATATRRTYAVESRWRARDLWGVVLAAIVIAVPALAAVLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH7</accession>
    <name>W4TJH7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Abhydrolase_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="ESTHER" id="proac-q6a6l8">
        <property type="family name" value="Abhydrolase_9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69110">
        <property type="protein sequence ID" value="GAE69110"/>
        <property type="gene ID" value="JCM18909_2298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027787">
        <property type="entry name" value="Alpha/beta-hydrolase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10081">
        <property type="entry name" value="Abhydrolase_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_9" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="6009" checksum="D8B2E701DB81E069" modified="2014-03-19" version="1">MIWAEPDWMRERAGNDVNPHILWTPWSSFLAGNRRHGPSDDPTRRPRSQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH8</accession>
    <name>W4TJH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68697">
        <property type="protein sequence ID" value="GAE68697"/>
        <property type="gene ID" value="JCM18909_1848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="15432" checksum="562752ADACC8CEB0" modified="2014-03-19" version="1">MPKRYLGALIGLGLLAVLLLIAITPYRAERVLSFLHPDNGASTSQQPLSAIYALATGGWWGVGIGASRQKWGGLYDGAQNDFVFAVLGEEMGLLGTLGVILLFTLLIWAGVRTAMRQDSLFRRSAASTATAWIAVQASSTCLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK2</accession>
    <name>W4TJK2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68946">
        <property type="protein sequence ID" value="GAE68946"/>
        <property type="gene ID" value="JCM18909_2122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6813" checksum="A9C1C8C3CC9ACFE7" modified="2014-03-19" version="1">MRSSSATPARAYLVPALGDSWKLFRKYVSKGDYILDPASTLVKVFEHIWLASRIRDEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM9</accession>
    <name>W4TJM9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A export ATP-binding/permease protein MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68349">
        <property type="protein sequence ID" value="GAE68349"/>
        <property type="gene ID" value="JCM18909_1478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11531" checksum="24A3B316E5DD468D" modified="2014-03-19" version="1">MLVNGTDVRRYDPETLWSCIGLVPQRPYLFGGTVASNLRDGRCDATDEELWNALRVAQSDDFVSHMDGKLEATITQGGTNVSGGQRQRLSIARALVKDPDIYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJS7</accession>
    <name>W4TJS7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68389">
        <property type="protein sequence ID" value="GAE68389"/>
        <property type="gene ID" value="JCM18909_1524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="270" mass="28946" checksum="9FF94E3D4076C854" modified="2014-03-19" version="1">MRIVISQQGYERIFFVTNAEPTTTLQEVLEGAHIDLRHFEHVWVDGREVDRSLGIREVGLCEGAVVSDTPGTTGDADRRVSEHWQLVIVGGATCARVYDLPASGLARIGRSDEVEISLESASVSWSHAVIDVTEDGVHVVDHDSANGTYLNGKKIGGDPTHPALMQPGDVLSVGGVCLMLSDPRQRAAQRAYGVVGKVQTAGAGGRIAFNRPPRAALPPHAGQVSVPVRKEPDSPARFSWIAVIAPLLMAGLLVFVLGSTRYASSRCCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ1</accession>
    <name>W4TJZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator MtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68429">
        <property type="protein sequence ID" value="GAE68429"/>
        <property type="gene ID" value="JCM18909_1567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15539" checksum="DA87411674EFBE73" modified="2014-03-19" version="1">MDAAGDHGPILVVDDDAALAEMLQLVLIKEGFSTAWVGHGSDVMDVFHEHRPALVLLDLMLPGRDGIRICQDIRRESGVPIIMLTARSDTPDVVQGLGAGADDYVCKPFRSAELIARIRARLRTPVAQREEGDGHYRRGPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK84</accession>
    <name>W4TK84_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68917">
        <property type="protein sequence ID" value="GAE68917"/>
        <property type="gene ID" value="JCM18909_2090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="6">
        <location>
            <begin position="3"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12292" checksum="FF703062EEE3F60A" modified="2014-03-19" version="1">MRFPVTSGPLAGRAKLLVWTTTPWTLVSNTAVAVHPEVRYVVAHQDPVPEGSDAVATASAEDPASQDLIIAEPLFEKKCWVRGGALPASPSWARRWNCGPTSAPTISWSGQRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKD6</accession>
    <name>W4TKD6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter NhaA type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68893">
        <property type="protein sequence ID" value="GAE68893"/>
        <property type="gene ID" value="JCM18909_2065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="283" mass="30850" checksum="89BCE7AD83E51411" modified="2014-03-19" version="1">MTDSRKNKRPRKSILRPVTGPNALHLSDIFRNETTGGMLMLAATVAALLWANLGHHSYHFFRELALGPLTIEQWAADGLLTVFFFIAGLELKREFVEGSLSRPADALVPIVAAVCGMVFPAGIYTLFNVLASDGHPAGWAIPMATDIAFALAVLAIVGAGLPQAVRAFLLTLAIADDLGSIIVIAVFFSTGLDIWWLTGAIACIGLWGVMQHFHVDNGWWYVPIFIVGWWCMLRSGVHATIAGVAFGLLTRTEEDILDDPVDRWQHKVEPWSAGVVVPFFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKM0</accession>
    <name>W4TKM0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68958">
        <property type="protein sequence ID" value="GAE68958"/>
        <property type="gene ID" value="JCM18909_2135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18543" checksum="1CDEED698EEDC3B3" modified="2014-03-19" version="1">MTDNKTTSAKSDATKTENLPETTTKETLPPSPLHTDHGSTLIAEQVVQKIAGIACREVPGVHAMGSTGRRMLSSITDRIPGSTTNVSNGVQVEKGERQCAIDLSVVIEYGYSVVEVANKLRETIIDAVEYGTGLEVVEVNVQVTDVYIQGEDDHDDDQSDQVAGQRKNTELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR1</accession>
    <name>W4TKR1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69371">
        <property type="protein sequence ID" value="GAE69371"/>
        <property type="gene ID" value="JCM18909_2580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12987" checksum="42A559F2F8572B62" modified="2014-03-19" version="1">MAVVVSYSVLNFVIQSIIQPKFAGDAVGLTPTMSFVSLLLWGWVFFGALGTLIALPCSLLVKATLIDHDPGARWVNALISSRPQKGLRTTSMSSMPVVFGRADRERLWNCRAHRVDSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS6</accession>
    <name>W4TKS6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69550">
        <property type="protein sequence ID" value="GAE69550"/>
        <property type="gene ID" value="JCM18909_2779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="237" mass="24356" checksum="1ACC85736862EE87" modified="2014-03-19" version="1">MHAITVRPTDKTDSKGRHRPGPECIEWTEVLTPKPGPAEVLVKVKAAGINRGDLLQRQGLYPPPKGVSETMGLEVAGTISSLGPGVTGWSEDDEVIALLAGGGYAEYVIVPAGQLLPIPEGIDPVTASTLIEVSATVISNMDHVGLARGETFLVHGGAGGIGQFAIQYAKSLGCTVITTCGTARSRSSAAPSVPTSPSTITRTGLPASKRLRGVVVPTSSSTSWALSTSTSTSMLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKS9</accession>
    <name>W4TKS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68764">
        <property type="protein sequence ID" value="GAE68764"/>
        <property type="gene ID" value="JCM18909_1921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="288" mass="31792" checksum="7257EF4B4BB8E4E3" modified="2014-03-19" version="1">MKAMAESTSSVQVPDPYRLELVTSDGSRSEAVDNVLRAVALGFHLSQPSDAELEHYAACVEGEQLWTIRQPDPDPEFPNLPVATMDTYPSTINTGHGHLEPATFITDVTVRASHRRRGLLRTLMTNTLARSKEEGLAFAALTATEGSIYGRFGYGISTRDQSVEIVVDGRFKLNHAPSGTVSMADPLAIDDLRLKVFSEFHRARRGSHNRQPWHVDYASGRWDLRRAAQTVASVRSFITTTMANPTASFPTRSTRISVHRSPSSTWSPPPRTLRSRCGSSSPRLTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU8</accession>
    <name>W4TKU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69152">
        <property type="protein sequence ID" value="GAE69152"/>
        <property type="gene ID" value="JCM18909_2341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="185"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="608" mass="66989" checksum="36BF6E16CA0A1281" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV4</accession>
    <name>W4TKV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transaldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69580">
        <property type="protein sequence ID" value="GAE69580"/>
        <property type="gene ID" value="JCM18909_2813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="278" mass="31170" checksum="05FA60B49F8FA391" modified="2014-03-19" version="1">MAGHQRHVSRGRKAPRADLRRVQGPKRSSLHPDRSALHRDAKALADQAEEFSNLAPNIIVKIPCTSVGIEAIEEATYRGVSVNVTVSFTVPQAVRSAEAIERGLQRRVAEGKPIDEMGPVVTIMAGRLDDWLKIVAERDRLFIDPGHLEWAGIAAIKRATQIFVERGFHSRVLCAAFRNVLQWSELIGGDLVVSPPFKWQKRINDSDYHVVPRIDEPVAAEHLDALKKIPEFMRAYDPDGMTIEEFDTFGATRRTLRQFLQADVDLDTLVRDIITPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW7</accession>
    <name>W4TKW7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69172">
        <property type="protein sequence ID" value="GAE69172"/>
        <property type="gene ID" value="JCM18909_2363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15130" checksum="43EA4C08D0703058" modified="2014-03-19" version="1">MAIDTVDEPDAELGDLTRLAAVFKSLGDPHRLVIVQHLFRGEHRVTDLVAHLGLAQSTVSSHVATLRDAGLLASHAHGRAMYYTLAHPQQIRRLMLLADILIRDGGECAELCGMPDVEYRGEPNDDHIGGNDDAARAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW8</accession>
    <name>W4TKW8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69078">
        <property type="protein sequence ID" value="GAE69078"/>
        <property type="gene ID" value="JCM18909_2262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="379" mass="40802" checksum="7E00AED3BD47D041" modified="2014-03-19" version="1">MQYPLTPKPVRRSGALPIVITVLGAIVILLIVALISAGSPVTFIVGAIPSTAALIVCLLCYRWLDRWEPEPTRLTVMALIWGGSAGVIFSFLVEMAVPASEFVTMAIVAPLAEELAKASVFILVATGARKLELTSLTDHIFYAGICALGFAFVENLGYFALSSSAGEFVVMTLVRTGFGVFGHPLYTTATAVGIWAWRTKGGLWKAAVGYIAACLLHGLWNGGPTLLAGSLGLDDTGQLAAMILVYIVLFVPVFIGTIIMTTRNRRNEYEAVRSQLPLMVKAGLVTPAEADMIADPRKRRTVLADSGKHGRTAKRSQKRTITAATEAALAQHRIAAGEGGPELVKRRDQLSEWLRSRPDKLGQLPLMPQFPPIQPPATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL03</accession>
    <name>W4TL03_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">JCM18909_2411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69217">
        <property type="protein sequence ID" value="GAE69217"/>
        <property type="gene ID" value="JCM18909_2411"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE69217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24076" checksum="9221D90E0129CEC3" modified="2014-03-19" version="1">MVVRITPSILNANLANLASEVGRIPSADGLHIDVMDGHFVPNLVMGAPFVESLRPATNLMFDVHLMIENPDRWAPQYVEAGAQSVTFHLEAATAPIKLARELRSMGARASVALRPATPVEQLADILTEFDQILLMTVEPGFGGQKFLDLALAKIRKARKLIDATRKDIWLQIDGGVSADTIERAAEAGADTFVAGSAVYRSDNPDHVVASLRNRALAAQVCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC1</accession>
    <name>W4TLC1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal-protein-S5p-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69780">
        <property type="protein sequence ID" value="GAE69780"/>
        <property type="gene ID" value="JCM18909_3032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5761" checksum="6EBE3A6843820C44" modified="2014-03-19" version="1">MTMQAGGVVLRPMRRADEVRWTTTRELDWDWLGPWEATKLLALMSGLAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC3</accession>
    <name>W4TLC3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69238">
        <property type="protein sequence ID" value="GAE69238"/>
        <property type="gene ID" value="JCM18909_2432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9302" checksum="DD3A365139B55A72" modified="2014-03-19" version="1">MAILRAVPHVEGCQSRSPETVTVSDPLVLRWINGWVVAIFVGVADVALAGVSSTVDGDGMEEASDALDEAAGRGTPVSSGAAWLRIRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD4</accession>
    <name>W4TLD4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68959">
        <property type="protein sequence ID" value="GAE68959"/>
        <property type="gene ID" value="JCM18909_2136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6260" checksum="F722B7FF30464E66" modified="2014-03-19" version="1">MCRCLGGTFVTADPEIGRKKFPTPRLSYPQKHPMTRGTMTMSTTMQGLTVLEGGAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI0</accession>
    <name>W4TLI0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ORF">JCM18909_2581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S14.008"/>
    <dbReference type="EnsemblBacteria" id="GAE69372">
        <property type="protein sequence ID" value="GAE69372"/>
        <property type="gene ID" value="JCM18909_2581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="441" mass="47837" checksum="0F1C60DB940F0AC2" modified="2014-03-19" version="1">MPAMAGPETGGAGMTDNVYQSLLRNRIVFLGSEVKDENANALCAQMLLLNAEDPEADIYLYINSPGGSVTGGMAIYDTMQWISNDVATVTMGMAASMGQFLLTAGTPGKRYALPHAKILMHQPLGGVGGTATEIAINAKMLKDTKRELSQLNAVHSGHTLEQILEDSDRDHWFTAQEALEYGSLTTSTAMRRSFAATPRISEVTMGFNAFDKNRLAALNAEQAEQAAPGGLAPAGPRNDYYIPQWEERTSYGVRRVDPYTKLFEDRIIFLGTPVTDDIANAVMAQLLCLQSMDADRQISMYINSPGGSFTAMTAIYDTMNYVRPDIQTICLGMAASAAAVLLAAGAKGQRLSLPNSTVLIHQPAMGQATYGQATDIEILDDEIQRIRKLMESMLATATGQSVEQISKDIDRDKYLTAQGAKEYGLIDDIFDLTVRFGAVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ5</accession>
    <name>W4TLJ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uroporphyrinogen-III methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69616">
        <property type="protein sequence ID" value="GAE69616"/>
        <property type="gene ID" value="JCM18909_2854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="14697" checksum="66810952DEB6FFA0" modified="2014-03-19" version="1">MRIIPGVTSCVAGPELMGVPLTHRHMVQGFTVVSGHVAPGDTRSELDWAQIAETGTTLVILMGVAHIGDIATRLMDGGLAGDTPVAIIADASLPTQRSLTTTLEKAAEDMAEAEINPPAITVVGDVAGLDLDETQVHAPSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN9</accession>
    <name>W4TLN9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69666">
        <property type="protein sequence ID" value="GAE69666"/>
        <property type="gene ID" value="JCM18909_2911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024551">
        <property type="entry name" value="AspAT_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12897">
        <property type="entry name" value="Asp_aminotransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16111" checksum="52C3DD82F6005059" modified="2014-03-19" version="1">MTTPLIDLSHDDLSALHQQLSSEHADLVARGVCLNITRGKPSPTQLDLNADLLTIDVPSHAEDGRDVRNYGGNRGLPEIRRIFGELLGVDVDHIIAADNSSLSIMHDLAMFAFVHGIAGQKPGPVRTSSSSPQFPVTIDILPSASIWALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT4</accession>
    <name>W4TLT4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 4"/>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69920">
        <property type="protein sequence ID" value="GAE69920"/>
        <property type="gene ID" value="JCM18909_3187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5296" checksum="789C8DDCD4C424C7" modified="2014-03-19" version="1">MNYVGVNGRTGKEFDSSYKRGTTADFPLAQVVPGFAKGLVGKHQATGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLX2</accession>
    <name>W4TLX2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69517">
        <property type="protein sequence ID" value="GAE69517"/>
        <property type="gene ID" value="JCM18909_2742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="9019" checksum="6D0514E8D683B659" modified="2014-03-19" version="1">MAPVQVRLDQLVTTKSTLNLANLLEDDSTFYGDLFAHVVAWHGDLYLEDGLHRALRAALQQRQTLHARVLDLNGHHDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMA9</accession>
    <name>W4TMA9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium-dependent galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69543">
        <property type="protein sequence ID" value="GAE69543"/>
        <property type="gene ID" value="JCM18909_2770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="518" mass="55391" checksum="92FEDFC3EACEA678" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG7</accession>
    <name>W4TMG7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_101 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69384">
        <property type="protein sequence ID" value="GAE69384"/>
        <property type="gene ID" value="JCM18909_2593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:glycopeptide alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14244">
        <property type="entry name" value="GH_101_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025706">
        <property type="entry name" value="Endoa_GalNAc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12905">
        <property type="entry name" value="Glyco_hydro_101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_101" evidence="1">
        <location>
            <begin position="9"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="311" mass="35662" checksum="E90B22ABC9AB1EB5" modified="2014-03-19" version="1">MPTAKVDWQDAAVATRDVTMKPTGSGDVANKVITHIPFNIVSQATHPFLRTLYDVKRISLATDGLGQQALLKGYQAEGHDSAHPDYGGNVSHRACGMKDLQKLTESGRQWNANFGIHINLVESYPEANHFGDNILVKPYQKAWDWMEQSYRMDYAKDLGTGQLFARLNQLRKELGAKSNLDWLYFDTNYPAGWQNDRIANALNAEGWKIGSEWSSTYPRYNQWSHWANDENYGTGNKGYSSRIIRFIDNSRRDTWNPDPILGNSNVVEYEGWTSHNDYNAFIANVWQRNLPTKFFAAFGHYILARRPYRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI1</accession>
    <name>W4TMI1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_3493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70195">
        <property type="protein sequence ID" value="GAE70195"/>
        <property type="gene ID" value="JCM18909_3493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="129"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="162"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE70195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="365" mass="39048" checksum="C24BD849C6BBB370" modified="2014-03-19" version="1">MDVVRAFGLENLRTRAVANGSWQAIRWNLRGRFLGNTLVVRLLAGEAVATIGVAWTGYLLVTTDRLSVGAAATAVLVLLRLFSPVRFLLMFLNNLQAAWVCLQRVVGVIQARHDKPAVSERYQREPTSIHVDQVSFGYQDGPDVLHTVSLDIPAGHTVVLVGESGAGKSTLAALVAGLLEPRQGSITMTSGHARTVLISQDIHTFSGTLFDDVALGLPAQAEDWPDERVRDAVLAALERVGADWVEQLPHGVDTVVGRLGTRLSPAQAQQVALARALLADPPVIILDEATAEAGSSGATALDRAAAEVVRGRTALVVAHRLSQVTMADEVAVMEGGRIVEVGAPEQLRQSDGPFAALWRVWSNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM7</accession>
    <name>W4TMM7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69678">
        <property type="protein sequence ID" value="GAE69678"/>
        <property type="gene ID" value="JCM18909_2923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="6">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="30707" checksum="403FAF90D13AA8BA" modified="2014-03-19" version="1">MLSVSADLIDIACDDGTYQTYKLEKFRRSNAGTCINQRPLVKVGQRVEVGTPLADGPSTDNGELALGRNMLAAFMPWQGLNYEDAIILSQRIVSDDVLTSIHIEEHEVDARDTKLGAEEITRDIPNVSEDMLANLDENGIVRIGAEVGTGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGEEGTVIGVRIFDTENGDELAPGVNQMVRVYVARSARSPSVTSWPDATVTRASSRRFYLSRTCRSCRTAPLSTSSSTVGCALPNERRAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN7</accession>
    <name>W4TMN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69807">
        <property type="protein sequence ID" value="GAE69807"/>
        <property type="gene ID" value="JCM18909_3062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6100" checksum="790DCB62BF9FD573" modified="2014-03-19" version="1">MAAERNGIADADLKLLGSIFGQSDLVGLRRPGPSLTVDQRKGSAGTWWRSIITESCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS0</accession>
    <name>W4TMS0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uracil-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70280">
        <property type="protein sequence ID" value="GAE70280"/>
        <property type="gene ID" value="JCM18909_3587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13458" checksum="7CC51DF1E67956EE" modified="2014-03-19" version="1">MADVRVLIVGQDPYPTPGHPVGLSFSVEQDVRPLPRSLQNIYTELQSDLGIAPCEHGDLTGWFEQGVLLLNRCLTVQPGRPASHRGKDGRRSPRRRSKLWWRAAVRWWRSYGDAMRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMS6</accession>
    <name>W4TMS6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dipeptide transport system permease protein DppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70016">
        <property type="protein sequence ID" value="GAE70016"/>
        <property type="gene ID" value="JCM18909_3296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="344" mass="37677" checksum="48786C7D04D2442F" modified="2014-03-19" version="1">MADPTPGENDVLGNSKPRSVWNDAWDSLERNPLFWISVTLIVVFLVMAAVPAIFTSKDPTDCNLSAARHIPSAVHWFGTDIQGCDVYSRTVYGARSSILVGVLATLGTTILGAFIGLVAGFRGGWLDTLLSRTGDVFYAIPLLLGGIIILYTFPNEPGTPYLVMVLKVVGAIIILGWPSIARLMRSSVLQVLPHDYVQAARALGASSWRIIRSHILPNAVTPVIVVATINLGAYIAIEATLSYLASACRNQPSHEVCRFLTPPGWDTSAQHRSCCFSRHYSCLWRCWHSSSLARRHRTPSTPNSTEVSTWHERHSRALVFTWNRLTGCSLKSTTCTWSSAPVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMT3</accession>
    <name>W4TMT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sucrose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69728">
        <property type="protein sequence ID" value="GAE69728"/>
        <property type="gene ID" value="JCM18909_2977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="299" mass="33782" checksum="394C4941AE998E1E" modified="2014-03-19" version="1">MIYHNSLMVQLWSALATRDVSLMETALSRTPDKPSTTTWATYARCHDDIGWTGDDTDARETGLDPVAHRRFLSDFYSGKFPGSFARGLVFQDNPVTGDRRISGSLASLAGLESALESDDPAGVDAAIARIVMLHTAILGYGGVPLIWMGDEVGTLNDDWQRDPDHADDNRWVHRPMMNWSMVEQAHDEPHSVPGRIWNGVRRAINARRRSPEFHASVDTVVLPSPHRKVIMWGRPHPEGRMIELYNVSEHEVWFPMETLRSELDDVVTELLSGFDYDLTPMNLRLAPYECLWLSDRSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMV2</accession>
    <name>W4TMV2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="8" type="ORF">JCM18909_2739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69514">
        <property type="protein sequence ID" value="GAE69514"/>
        <property type="gene ID" value="JCM18909_2739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="6">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DPBB_1" evidence="7">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="23536" checksum="3D6F9CFCF317568B" modified="2014-03-19" version="1">MATRYITKVNRPVGIYAQRGDHNARSKAVQRDLSTLNYFPAKWVGLPYGPVTTNAVKVFQRANALKQTGVTDAVTLSLLKSKADYQRAAVAEKSSTYKHAEHHSEHSPSTSRSTARPARSTSSDVSTSGIAGSCQASFYDDSQTASGESFSSSALTAASKTYPFGTRLKVTNKANGQSVVVRINDRGPYVSGRCLDLSPAAFSQISSLSAGVADVTYAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMV5</accession>
    <name>W4TMV5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69872">
        <property type="protein sequence ID" value="GAE69872"/>
        <property type="gene ID" value="JCM18909_3135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7416" checksum="6617326A3325BA7D" modified="2014-03-19" version="1">MADRQEGPHAHQVTWLDRAHLAVTDLGADRINVVRWSEAGPEIIGSLKTLRDVARVTSPSPKMGASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX3</accession>
    <name>W4TMX3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69763">
        <property type="protein sequence ID" value="GAE69763"/>
        <property type="gene ID" value="JCM18909_3014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7037" checksum="FE4C0551DE04ABA6" modified="2014-03-19" version="1">MITRIASHHVVDRDGSDSPATITVEAGRISDVSEGIDPKAELVDEWILPGYVDTHCHGAPVLTSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMY6</accession>
    <name>W4TMY6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69554">
        <property type="protein sequence ID" value="GAE69554"/>
        <property type="gene ID" value="JCM18909_2783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="231" mass="24878" checksum="64A1476F72F61486" modified="2014-03-19" version="1">MWTTLLLSALIRIPIFSLGIVMSVHVVSSLHLDYVRAGAVTTVVTVATMISGPWRGSMVDRRGLRRTMLPSLITTTITWGLCPWLGYFPLLVLCAIGGLWNYPIFTIPRQVLMAAVPASRRRAALSLDSVTVEICYMIGPTVAIIAATTIGTRITITACGFVAAIGAIGLMVLNPATTEPSEDSPAPPALRPRPRRSSRRHIAARWRGYPPGQHPSSLQSLPPGFVLGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN03</accession>
    <name>W4TN03_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA_permease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70355">
        <property type="protein sequence ID" value="GAE70355"/>
        <property type="gene ID" value="JCM18909_3670"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="132" mass="14068" checksum="5729DB1BF33A8C4D" modified="2014-03-19" version="1">MWPIAPVWLLTLIFLVVLTAINLLGADRFGEFEFWFALLKVVAVVVFLAIGVLLICGVLAAPAAGTSNLVGHGGFLPNGWSGVATALLLVAFSFGGIEIMAVAAAETEDPAHNVSRAVRTIVWRILVFYMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN88</accession>
    <name>W4TN88_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69992">
        <property type="protein sequence ID" value="GAE69992"/>
        <property type="gene ID" value="JCM18909_3268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="208"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="403" mass="44052" checksum="009DB39A9CEF1706" modified="2014-03-19" version="1">MSAEMYETSDNKLSAGIPVDIWAIPVVRRGEVIAVVERHTNQMGVRAPGNTEDNYLEIADILSEMLHHGRFPQFPGSDRALAPKVTDGVIRVAATGMITFASPNALSAFRRLGLAGDLDGEYLIPTVRELCPRLREVGQSLTLDLEGRWLTETDIENSDATVRARVIPLQTWLDDVEVSAGTLILIRDLTELRDRDRQLVTKDATIREIHHRVKNNLQTVAALLRLQSRRMSNSDAKDALKQAMGRVSAIAVVHEILSQNFEEQVAFDEVADRILHMVGDVAASSGSVVARREGSFGEVPAETATALSLATTELCQNAIEHSLDSSSGNVIVRPHRTDDALVVDIVSDGKPLPEGFSLDNHRSSLGLSIVTTLMQDLGGTFTLEDNSDRVGTCARLVIPLQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TND4</accession>
    <name>W4TND4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70251">
        <property type="protein sequence ID" value="GAE70251"/>
        <property type="gene ID" value="JCM18909_3554"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8595" checksum="A9CF07592347CEE1" modified="2014-03-19" version="1">MQPLLWRPLGMSRIKMTVLGGIKLSEVKQSTVLLPIGDDEQVRAALDALWPRFRLDAVPLHGIPKRARWFRWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF5</accession>
    <name>W4TNF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70490">
        <property type="protein sequence ID" value="GAE70490"/>
        <property type="gene ID" value="JCM18909_3817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14427" checksum="D6E036339894EDF4" modified="2014-03-19" version="1">MKDLHLSLPTAAELPASNTARQTYDVLEQKFGPGFNGPVIVTADVVSSHDPMRIVNGLKADIEKIPGVDTVALAVPNRNADSAMIQVLPTTGPADEATNNLVRTLRDHETQWRDTYGVDTAVTGLTASSSMSRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG6</accession>
    <name>W4TNG6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PTS EIIA type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70082">
        <property type="protein sequence ID" value="GAE70082"/>
        <property type="gene ID" value="JCM18909_3368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10736" checksum="E5989C455BADD4D6" modified="2014-03-19" version="1">MKRFLDPTLFFTGRSFDSWRETLDFMCGSMERNGIVLDAFRESFFLREGYSSTVFFRMFAVPHAMDFLAYETKKLRSSYLQLQSTGKRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK1</accession>
    <name>W4TNK1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3243</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69968">
        <property type="protein sequence ID" value="GAE69968"/>
        <property type="gene ID" value="JCM18909_3243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="74"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26776" checksum="3677E75D54250EC4" modified="2014-03-19" version="1">MASVNADDEDRFNQMVDRRRSGEPAQYIIGHAWFRGLRLEVGPGVFIPRLETELVAEQSIQEARRLVMSGACPSVIDLCTGTGAIALAVANEVPGSRVSAVEVDDAALTWTRRNLCDSGVEVLAGDALRVPDDGRRFDVVVTNPPYLRRSDASSIPGEVTEHEPDLALFSGDDGLDLPLLLIGRAAELLTPGGLFVMEHDEIQREELVAAMATSDMWEQIEDHDDLAGRPRFVTARRRCKDGCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK4</accession>
    <name>W4TNK4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmH</name>
        <name evidence="7" type="ORF">JCM18909_3879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TNK4"/>
    <dbReference type="EnsemblBacteria" id="GAE70540">
        <property type="protein sequence ID" value="GAE70540"/>
        <property type="gene ID" value="JCM18909_3879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="5169" checksum="122F713DCBAE4AFB" modified="2014-03-19" version="1">MKRTFQPSNRRRARNHGFRSRMSTRAGRSILAARRRKGRVNLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNL1</accession>
    <name>W4TNL1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Threonine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69978">
        <property type="protein sequence ID" value="GAE69978"/>
        <property type="gene ID" value="JCM18909_3254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6309" checksum="D93BF80B4F90B541" modified="2014-03-19" version="1">MAGLFKLKSEGRLDPGLRIVVTVTGNGLKDIDTALSRTILSTEAVEASTDQVAALLDFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX4</accession>
    <name>W4TNX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000065">
        <property type="protein sequence ID" value="GAE70680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70680">
        <property type="protein sequence ID" value="GAE70680"/>
        <property type="gene ID" value="JCM18909_4056"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8994" checksum="783BA2B4AD863A49" modified="2014-03-19" version="1">MRVEGVVTSLNADVDNVIDSRIRFQISLDDILVLDCRRISGDNDPQSHGSSMSRCRVLKRPTRNCEQQRLMTFILTAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPA5</accession>
    <name>W4TPA5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chloride channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70357">
        <property type="protein sequence ID" value="GAE70357"/>
        <property type="gene ID" value="JCM18909_3672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="222" mass="22864" checksum="EACBCED1BB5407A9" modified="2014-03-19" version="1">MAAPRFFDRLDKVPGWLVPAIGGLGVGLLGLLIPAALGTGYGSVQQEMFANNLVRMPLLMVLATPFAKILSTTLSIGSGGSGGVFGPGMVIGGATGAALWRLLEGLPGIPSSPMSFVIVGMIACFGAVAHAPLGVLLMVGEMTGNLSMLAPGMIAVAVAGRVVGDTSIYTSQLKDRLEGRRVHTMGRVTKLSEPKSDDEVASPKPAIKKPSGKKYFPLEACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK0</accession>
    <name>W4TPK0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobN component of cobalt chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000061">
        <property type="protein sequence ID" value="GAE70661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70661">
        <property type="protein sequence ID" value="GAE70661"/>
        <property type="gene ID" value="JCM18909_4032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="577" mass="63283" checksum="24CE9C81B13A9482" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPR5</accession>
    <name>W4TPR5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Biotin repressor from TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70219">
        <property type="protein sequence ID" value="GAE70219"/>
        <property type="gene ID" value="JCM18909_3517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003012">
        <property type="entry name" value="Tet_transcr_reg_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00400">
        <property type="entry name" value="TETREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE70219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="204" mass="21873" checksum="1B26B2B679018EFA" modified="2014-03-19" version="1">MWTIPGNGVVVKGVIVSLTKPDVVRAGVEILDAYGLGDLSMRRLAERLGVKAGALYWHVANKQSLLAAVSDEILAVDGGPTTVPSQGAELSDGVDEWARCFRATLLAHRDGAELVASTISVGLGRTDPTVKLRQFMECQGVCRERADSVCRALVHLVLGHTMEEQTRTQLHDLGVVGKIDPARQDDDFDLALAIFFIAGLASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPS8</accession>
    <name>W4TPS8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70234">
        <property type="protein sequence ID" value="GAE70234"/>
        <property type="gene ID" value="JCM18909_3532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="8">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5565" checksum="19005117399977A8" modified="2014-03-19" version="1">MSAFLAERGIDAHLIHLDGAVESSIRLGVADAIADVVETGTTLRRAGLEIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPT2</accession>
    <name>W4TPT2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inner membrane protein translocase component YidC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70537">
        <property type="protein sequence ID" value="GAE70537"/>
        <property type="gene ID" value="JCM18909_3876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="170" mass="19410" checksum="06B78FB0DE2C0E53" modified="2014-03-19" version="1">MESLQHAKFFGAELAGRFLPMNNGFGGTQVVALVLIIIMVATLFYTQLQLMRKNMPPESLTGPMAQQQKMMIYLFPLMYLFSGVSFPIGVMLYWSTSNLWTLGQQEILIRNNPTPNTPAYIDWRERMIAKGKDPDEIERARREKRRRKVVAPTPVATTEDGEKPMVLAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPU4</accession>
    <name>W4TPU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lanthionine biosynthesis protein LanB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000052">
        <property type="protein sequence ID" value="GAE70552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70552">
        <property type="protein sequence ID" value="GAE70552"/>
        <property type="gene ID" value="JCM18909_3893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006827">
        <property type="entry name" value="Lant_deHydtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04738">
        <property type="entry name" value="Lant_dehydr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lant_dehydr_N" evidence="1">
        <location>
            <begin position="35"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="424" mass="47226" checksum="1DF93FB9A190406A" modified="2014-03-19" version="1">MSIIQILERRLSQVYADSRDEVPRHYRSLYQADAIEPSIQLSGGQLHSDLTRLISHDSRIKPTKERTLETTLVNYLYRAATKPSPFGRFVEVGAFDPSQPNSEPRRCSESSVTTNRILTSWLTAVTAHSFAAPEMLAILNSALRVKRDIIQFIGIPPGEWRGAPSIPEERLLTIRKREDMMSVLKLLMGGPRSVGDLIIALNDQGIDESHATNLLSSLSTAGIIFFRLPVDDHDVHYVQTACTALRLTKDESLRAAFQSLANAEKEFPTASVATRHDLLLGIKDSVNTVATAHDVPTPPDSALRSPLYEDLPATATPQTWDSNTVERSARALRSIWLLSDLMDSSQRRQLGLSQFIADMNNARQLLFLISSTRFRALAFASAKESCAEKTHRESPVSLSNIVMHCLKFAMPLTTRRAKPTLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ68</accession>
    <name>W4TQ68_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_4064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000066">
        <property type="protein sequence ID" value="GAE70687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70687">
        <property type="protein sequence ID" value="GAE70687"/>
        <property type="gene ID" value="JCM18909_4064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="314" mass="33429" checksum="6D601532C0501D8C" modified="2014-03-19" version="1">MSTVLPFDFGSSYQAIRKIGQGASGRVFEGVDRVHGDHVAIKILRSDLDDDAQLVQRFVNERRTLTELDHPRIIAVRDLIVDQGMLGIVMELATGPTLGAQLAASGPMAPAAALAVVRQVAEALSYAHGRGVVHRDIKPDNIILTNLDGADDPEVKVADFGIAKILGESSTATHLVGTAHYLAPELIRDNVLSPSVDVYALGVTLYQMVSGQLPFGAGDDNPYAVAERHLHSTPAVIPGLDDQVWGLISGMLAKNPADRLSDDDVASLAGNIIVDVEGQLPLSVPEGTLVPHAMTMLRQPTSLTAHQATRSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQC7</accession>
    <name>W4TQC7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ORF">JCM18909_3742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70424">
        <property type="protein sequence ID" value="GAE70424"/>
        <property type="gene ID" value="JCM18909_3742"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="27"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="429" mass="45250" checksum="CA968D65A31571BE" modified="2014-03-19" version="1">MLTDQHLWNAPRAEHLLTGRVTVPGSKSQTNRALVLAALSDGPSVLEGVLASRDSYLMSAGLQLLGADIQPIGPGSVQVMPGLAHPTSPIECGMAGTVMRFLPVVAALVPGQTRFVGDEQASRRPIAPVLNGLRQLGVEVDSDRLPFSLNAPDRLCGPKVTIDSATSSQFISALLLASARFPQGIDLRHDGASVPSTPHIAMTCAMLADRGVTVVSDEPCHWVVRPGPIHALDDVIEPDLTNAAVFLAAALIVGGSVTVPGWPTDSTQPGAQFMGIAEKMGAMVSRVDGSMTITAQGWQELRPLDVDLHEASELTPVVAAVASLARGRSRIHGVAHIRGHESDRLAALEHELANLGVEVQQTDNGLDITGRGADKLHGGKFGCYADHRMAHAGALLGLVIDGIELDDITCTSKTMPQFPQMWANLVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQM7</accession>
    <name>W4TQM7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000078">
        <property type="protein sequence ID" value="GAE70713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70713">
        <property type="protein sequence ID" value="GAE70713"/>
        <property type="gene ID" value="JCM18909_4096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="11448" checksum="4BD418E775779FCC" modified="2014-03-19" version="1">MMARTAMIEPLLSSFPRVTIWVPCWKSCNISLSGKINMSRIAFRPTKDRLGGYCFSIDAIGHVEDERIADALKGLYRSSRMMIFLRFYQKCLHKGFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQW9</accession>
    <name>W4TQW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid partition protein ParA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70639">
        <property type="protein sequence ID" value="GAE70639"/>
        <property type="gene ID" value="JCM18909_3999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8584" checksum="94810CDBEB1D3647" modified="2014-03-19" version="1">MTYQVAHGTRRALLFNKADWTRQYRDAHDGAAAVEGLDVLDAEVHRRVAYRQAIGTRPDDLGEFAQVAAQIKEMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE38</accession>
    <name>W4TE38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67225">
        <property type="protein sequence ID" value="GAE67225"/>
        <property type="gene ID" value="JCM18909_270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="175" mass="18730" checksum="32BE8602FA8C9A56" modified="2014-03-19" version="1">MIFVPFLTMLIMIPLTAFLIGPIGVYAGAGLANGLKAVNDVSPFIFAVLIPLLYPFMVPLGLHWPLNAVMLLNIQTLGYDYIQGPMGAWNFACFGATAGVLFLSVRDKDVTMRQTAIGALAAGLLGGISEPSLYGIHLRYKKRFTHPCWSAVSSVVSSSVRAAVCTPRPLSSLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TE71</accession>
    <name>W4TE71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67265">
        <property type="protein sequence ID" value="GAE67265"/>
        <property type="gene ID" value="JCM18909_311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXGXG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12915" checksum="BB162F0B2EE92BFB" modified="2014-03-19" version="1">MTEGEVLVLGATGRNFAAGMSGGVAWVRNLDVSRLNADMVDALPMEQADVDRVTELLELHQTETGSTLAGEILAQGAGGIRESFMKVLPRDYATMMKAMVDAEEHGLDENETTFMEVSHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEF3</accession>
    <name>W4TEF3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67166">
        <property type="protein sequence ID" value="GAE67166"/>
        <property type="gene ID" value="JCM18909_208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="376" mass="41766" checksum="F98CF576100BB1AD" modified="2014-03-19" version="1">MTAPANSGSRETVRDQASGTHWSLNVQDDTVGVVDFVASNERIGKIPVKLSYGIIERFSEGLYSSPNKTFEELITNSYDAGAREVWVYLATDLSSERATLLVVDDGESMTLDGLADLWKIGESRKRSETPPPGRKKPVGKFGIGKLATYVLAEKLTYLVHRDDEYLAVSMDYGRVSPSAELLDGVNLSLDVVRLTQDQALDAIKRALEGTAVEERAKLLAVLPRLDHWTAALLSTLKPTAREIKLGRLRWVLRSALPLNPEFKLWMNDDEIKSSKVDGEELWTFTVGKDDATLPKSSERPWGPAQSLEVEVEHLGESARVPAVRLPKAGIVWGERHPLQTTVGTWTQRRFGPQPRFLRAGPRKADQPLRGGLCRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEG0</accession>
    <name>W4TEG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67355">
        <property type="protein sequence ID" value="GAE67355"/>
        <property type="gene ID" value="JCM18909_405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_2" evidence="6">
        <location>
            <begin position="2"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="GAD" evidence="7">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="310" mass="34275" checksum="9F8C40CF84758F0D" modified="2014-03-19" version="1">MTFLVPARLAPGCWYALPQSPQLFKQLLMVSGMERYYQIARCYRDEDFRADRQPEFTQLDVEMSFVDQDDVIALAEETMAACWKIIGVDMPTPLPRITWHEAMDRYGSDKPDLRFGNEITEVTDFFANTAFRVFQAPYVGAVVMPGGAPYRAVSSTPGRSGRAPAEPRVWPTSRSLARACQKVQLPKNISEEEKAGIAEKVGAKPGDAIFFAAGSKTSSQELLGAARLEIGRRCELFDPSDWAFCWVVDAPLFKPTKEAEASGDVAVGAGAWTAVHHAFTSPTPDCWIPSTPIRVQLWLTLTTSLSTATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEG2</accession>
    <name>W4TEG2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two-component system, response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67176">
        <property type="protein sequence ID" value="GAE67176"/>
        <property type="gene ID" value="JCM18909_218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7466" checksum="5B4EB4E89E0811F8" modified="2014-03-19" version="1">MRSPRISLIARELDVLEASAQGLSNAQIAEFLVVSEATVKTHLSHIYTKLGVTSRSAAVAKARDIGFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TES1</accession>
    <name>W4TES1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphinothricin N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67450">
        <property type="protein sequence ID" value="GAE67450"/>
        <property type="gene ID" value="JCM18909_511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="15241" checksum="B35F5820925F2BFD" modified="2014-03-19" version="1">MATTNVEDRLTWWRELTADNRPLLVAEVNGTIAGYANYHRFRKGGGYDVTAEVTIWLDPQARGQGVGRKLMTELIRRARADDRLRNLLSVIDSGNERSIRFHSAMGFVEVGRLPHIAYKLGDWRTAVLMQLTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TET2</accession>
    <name>W4TET2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyruvate dehydrogenase E1 component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_71</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67037">
        <property type="protein sequence ID" value="GAE67037"/>
        <property type="gene ID" value="JCM18909_71"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004660">
        <property type="entry name" value="PDH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF3">
        <property type="entry name" value="PTHR43825:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16734" checksum="51AC0B042C7488DD" modified="2014-03-19" version="1">MYGENAEDVMYYLTVYNEPIVQPAEPEGVDAEGIVKGMYLLSKGSFESVGEDARRVQLLASGVAVPWAIEAQQLLKGDFGVVADVWSVTSWNNLRRDAMEAEEQAFPTPRTAGAPRTSPSAWPTLLVQSLRPPITRVRCPIRSPSGCRGIMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF93</accession>
    <name>W4TF93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67426">
        <property type="protein sequence ID" value="GAE67426"/>
        <property type="gene ID" value="JCM18909_486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10836" checksum="475C3B8BBE7053DE" modified="2014-03-19" version="1">MAQSFHGRYTYGVARRGWVGKAVRVTGTLASTRSNSGHVNGRQQGYSWTRIGHVNIGGKVAVNSDVSSGDTLRAADLRVQVCAEHWYGDHCVERLYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFB1</accession>
    <name>W4TFB1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67217">
        <property type="protein sequence ID" value="GAE67217"/>
        <property type="gene ID" value="JCM18909_262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="21094" checksum="365892BC620274B2" modified="2014-03-19" version="1">MRIMDSTPLDEKFHAVLFDLDGVLTPTALIHMRAWQEMFNEELSRHQGQNPYTDEDYFAYVDGKPRYDGVRDFLASRGITLPEGDPSDGPAAQTICGLGNRKNDLFNTVLARDGIQPYPGSRRWWIGCTRVVWRWRWSHRHAMPQQCSRRRGWPRISQYWWTATGRRLKDYPASRPPIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFC2</accession>
    <name>W4TFC2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67227">
        <property type="protein sequence ID" value="GAE67227"/>
        <property type="gene ID" value="JCM18909_272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16431" checksum="EA596B6B654544F8" modified="2014-03-19" version="1">MAVDDDEVIHALHHAGYRREGRLRQARVRGNGWVDEYIYSRLATDEIYTRTGHTGMLDSVLPTKRVISHVLLRDDAGRVLMCETTYKPDWELPGGVVEPIESPHAGAVRECREELGVPLDIPGTPSLIDWMPPALDGPTLSSSSMTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFC5</accession>
    <name>W4TFC5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-arginine:glycine amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidinotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67461">
        <property type="protein sequence ID" value="GAE67461"/>
        <property type="gene ID" value="JCM18909_523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015067">
        <property type="term" value="F:amidinotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033195">
        <property type="entry name" value="AmidinoTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10488">
        <property type="entry name" value="PTHR10488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633195-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="376" mass="43348" checksum="275AF2613B1EAE7B" modified="2014-03-19" version="1">MMTKIVNSWNDWDPLKRVIVGRADNSVIPPEESATSEKVPVDSAMRGMWGPRPLEKVEKANAQLDNLVDVLEKHGVQVDRPTPLQWNQAIGTPDFRNDSMMTCMPPRDILLTIGSEIMASANSFRCRYFEYLAYWPLMNSYFEDDPEFKWTQAPRPRLTDKSYKHNYYDERVSLEERLERTAAKDFVTTEVEPMWDAADVMRMGKDLFIQHGLTTNRKSMEWFKRYYPDFRVHAVNFPGDPYPIHIDATFVPLRPGLIINNPNRPLPQEQRKIFEANDWQIVDAAQPAHDTPPELCYSSVWLSMNCLVLDPKTVICEASEVHQMEQMDKLGMNVIPVAFRDAYPFGGGLHCATADVYREGTCEDYFPNQVDDPTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY6</accession>
    <name>W4TFY6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbamoyl-phosphate synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_84</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67049">
        <property type="protein sequence ID" value="GAE67049"/>
        <property type="gene ID" value="JCM18909_84"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="2"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE67049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="353" mass="39685" checksum="9B83323988CFEC8E" modified="2014-03-19" version="1">MLRDASIEIVRALGIEGGCNVQLALDPNSFQYYVIEVNPRVSRSSALASKATGYPIAKIAAKIAVGLTLDEIRNPVTGTTWSMFEPMLDYVVAKIPRWPFDKFARADRRLGTQMKATGEVMALGRTIEESLLKAVRSLEIGVDHLALREVADLPDDILEERLLHARDDRLFCLTEAIRRGRTVHELHEQTRIDVFFLDKIAHILDIEERLRACPEDPEALWIAKRNGFSDLAIARIWGKTPDEVRVHRVDNGIVPVYKMVDTCAGEFESSTPYFYSTYEMENESKKSRSVPAFSSWVPGRSVLARGSSSTTPPSTLSRPSSCRVRGHHHELESGNGVYRLLHLRQAVFRAVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG01</accession>
    <name>W4TG01_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_99</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67064">
        <property type="protein sequence ID" value="GAE67064"/>
        <property type="gene ID" value="JCM18909_99"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021408">
        <property type="entry name" value="DUF3046"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11248">
        <property type="entry name" value="DUF3046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7283" checksum="238DFAD017A80FBB" modified="2014-03-19" version="1">MTETQLWTRLAEVLGDDYCRIWAAQQAVPGLDSRTVQEALADGVDAKMIWRACWKTLELSDSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG04</accession>
    <name>W4TG04_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67363">
        <property type="protein sequence ID" value="GAE67363"/>
        <property type="gene ID" value="JCM18909_413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="473" mass="49409" checksum="4D5884E670712D14" modified="2014-03-19" version="1">MAAEQGLEVDRTKFTALMAEQRARAKADSQAKKGLLTDREAYSQVRALGETPFLGYTDLTVDTTVTGIIANGASVTAAEPGSVVEVVLAETPFYAEMGGQDSDSGIIRANGIDFEVLDVQRPVPGLIVHKVHLDGDLAVGDRVTALVNPATRFGACQAHTATHVIHAALRELVGPSATQAGSYNKPGYLRFDFSATKGLSDSLKDEIEERCNVAIHDDFEVTDTQMPLEDAKAMGAMAMFGEKYPPIVRVVELAGPWSRELCGGTHVASTGRIGMLSLLGEQSVGSGTRRVEALVSTDAFRHMAAERALVNELTGILKVQPDQLADRVSKLAADLKEAERKLGAARTRELLGQVDDIVAGTTPAGSFDLVAAKVPGVAGSDLRTLAAEIRARVKDRPAVVTLIGGTHDKPAMIVATTESARAAGAKAGALIKVGVAPIGGRGGGKDDMAQGAGSDPTGIDAALRAVNTELTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG20</accession>
    <name>W4TG20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67462">
        <property type="protein sequence ID" value="GAE67462"/>
        <property type="gene ID" value="JCM18909_524"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7187" checksum="63E59CFC5D5F67F6" modified="2014-03-19" version="1">MDMEPGIINVKQEVPGVGTMNQKKLGFVSMLLSATGMGLVGTFGRLSTPVDPTTGSKYIIGDFFGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG86</accession>
    <name>W4TG86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rossmann fold nucleotide-binding protein Smf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67164">
        <property type="protein sequence ID" value="GAE67164"/>
        <property type="gene ID" value="JCM18909_206"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17490" checksum="3CD63362C8295F9E" modified="2014-03-19" version="1">MAGVADLGVDERRARVVLAMLAEPDDPVTGALLRREGAVETLGLLDTDTTVPGLGRVDGQVWRDRLTSSGRLDGLERQLRMVEESRIATLIPGDAQWPRALDDLGERAPYVLFVRGATSFLARPMQDLVTVTGSRAASAYGEHVAGELAGDLANRERVLVAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGI2</accession>
    <name>W4TGI2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67642">
        <property type="protein sequence ID" value="GAE67642"/>
        <property type="gene ID" value="JCM18909_715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="255" mass="27900" checksum="AFDA1DE997DD219A" modified="2014-03-19" version="1">MSSPYQPGFQSTQQGDRSKSEFSFAPGETNILVTHYSPSLMTAWLKTELTVTSRRLLARKSNTLLGVIPLGHDDAAMPLGSISEVGVNSKFHPGRAIMAIVWLVLMISMFNAHQPVLGILALLLLIVAVLTTMDAELRVVNNAGSVTSLTVSALEKAKLQSFKQEVEQRLYAGQALLMHRESMNQAQNFATIQQAQMSALLAQGQLQNQLSNDKGQQPPTRCRTRTPRAESYRQIDDWPAGSFGVRSANLCAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ2</accession>
    <name>W4TGJ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67533">
        <property type="protein sequence ID" value="GAE67533"/>
        <property type="gene ID" value="JCM18909_598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PTS EIIA type-1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="15118" checksum="D8FE71B8E85FA4F7" modified="2014-03-19" version="1">MTPISSPMAGDVHPLADVPDPVFAQGLVGPGVAIVPIGEAEVTVVAPIAGRIVKLHPHAFVIQAEGFGVLVHLGIDTVQLNGRGFLLHATEGDQVAVGTPLISWNPSEVVAGGRSAMCPVVVLDVAPESVTPVEVETVEPGAALFNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL1</accession>
    <name>W4TGL1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67672">
        <property type="protein sequence ID" value="GAE67672"/>
        <property type="gene ID" value="JCM18909_749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9318" checksum="52B4B82AF07DCEA3" modified="2014-03-19" version="1">MDLYEYQARDLFEKHGVPVLRGIVAETPEQASEAAAKLGTPVVAVKAQVKVGGRGKAGGVKIAKSPDEAADAPRPSSVWTSRVTPFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGY0</accession>
    <name>W4TGY0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the carbamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67399">
        <property type="protein sequence ID" value="GAE67399"/>
        <property type="gene ID" value="JCM18909_456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="301" mass="32010" checksum="8DA67EC3AFC69666" modified="2014-03-19" version="1">MRILVALGGNALLRRGEIMTAENQRANVRIAANHIKEVAVDHEVVVAHGNGPQVGLLALQSTAYEEVGIYPLDVLGAESQAMIGYMIEQELGNVMPQDQQIVTMITMTVVDADDPAFKHPTKPIGPVYDEATARRLAAEKGWTIAPDGEYYRRVVASPQPRNIIEQKAIRQLVDSGVMVVCAGGGGVPCVYDEDGILHGAEAVIDKDLASAELAVRVDADLLVIATDVAGVFRNWGEPDQERIEQMHASDALNTEFAAGSMGPKVKAACNFALATGKRAVIGSLEDIQGLVAGTHGTAIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH17</accession>
    <name>W4TH17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Geranylgeranyl diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68265">
        <property type="protein sequence ID" value="GAE68265"/>
        <property type="gene ID" value="JCM18909_1389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27904" checksum="4F85A51ED9B9151A" modified="2014-03-19" version="1">MGLHKRDDRPMGVAVRAYYRSALSESRNLESWLELWDGAPHKSDLLPGYGWAFPEGDGTVNIGLGMLNSSAAFGHTDYRSLMKRWLSHLPAEWTLDEEHREGSIRGAALPMAFNRQPHYRDGLLLVGDAGGMVNPFNGEGIDYAMEAGEMAADAIAEAHYRGHRTPAAEKALQGYSRALQRHFGGYYRLGTIFVRLIGDPRVMKMCTTYGLPRRRLMRFVNKLLANLTDAKAGDLDDRIINILTRIAPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH80</accession>
    <name>W4TH80_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67788">
        <property type="protein sequence ID" value="GAE67788"/>
        <property type="gene ID" value="JCM18909_871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="4"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="230" mass="25451" checksum="4D788ECD11E15147" modified="2014-03-19" version="1">MARIIVIASCVVALAPYLALVKLGTILLSAHIDHEALVHTANLLVAAFCTQALLYVLALVITHFADLKLRSVLQGRIIGRLSRAPLAWFSSSSTGQVRKAIQDDTVQVHALVAHAPVDQTAAIGIPVVLLVYAFIVDWRLGLLCLATFPIYALLQWWSMRGMTAKTAEMDDKLADISANAIELTEGVHVVKNFGQTGKAHRRFTTTCEEFARFYWDWCGPLIKRPPYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH83</accession>
    <name>W4TH83_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68146">
        <property type="protein sequence ID" value="GAE68146"/>
        <property type="gene ID" value="JCM18909_1265"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="230" mass="25710" checksum="D12D1BE58373C1CC" modified="2014-03-19" version="1">MLFYIGGVNDTGQRDSKSIDLIDPATELIKDRKVNPFVIVFLPGKIRNGVDSECVDVGPYRHETWIMKIVIPQLESHYRVGHERGSRFIGGWSTGGYCAANLSTKYPRAFNAGFSLGGYYHPMFEDPRIANMAQPLMAKNSVVRRVQERKIERSVRFLSVLNPNDLQSWGPGRVPVVSNGQVGPDGGQFYHVAKGMKQFTFILLTGGGHRVSVYAPYTEQSLQWLGQFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH97</accession>
    <name>W4TH97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transport ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68335">
        <property type="protein sequence ID" value="GAE68335"/>
        <property type="gene ID" value="JCM18909_1464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4442" checksum="09144E7DF70B4243" modified="2014-03-19" version="1">MPQVPAMMAGTVAENIRLGCSDAPEAMLRDAWIAAEPRQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD0</accession>
    <name>W4THD0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Low-affinity inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67843">
        <property type="protein sequence ID" value="GAE67843"/>
        <property type="gene ID" value="JCM18909_933"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848753" evidence="7">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="247" mass="26138" checksum="E6B2AAA338F62A22" modified="2014-03-19" version="1">MSSTLLIVVIVVVTALAFDFTNGFHDSANAMATSVATGALKPKVAVIIAAVLNVIGACLSTEVAKTISGGIVNDHLVTAPMVFAGLIGAIIWNLATWLFGMPSSSSHALFGGLIGAVLVEAGMSGIDAGKIMSKIVLPALVAPFVAGIAALVATWLAYRITNHTAHHSSRMFLNGQRVSASMVALAHGTSDGQKDDGCHYSRPHFRWVPGLRHWPRMVGHPGCRVRHRSRYLLGWLAHHADHGQRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK8</accession>
    <name>W4THK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67659">
        <property type="protein sequence ID" value="GAE67659"/>
        <property type="gene ID" value="JCM18909_734"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9201" checksum="9015CB99F28F72F8" modified="2014-03-19" version="1">MGFIGWIVLGLIAGAIAKAIMPGKQGGGFLVTLLLGVIGAVLGGWLGSAIFNKPLGKFWSPWTWLISIVGALIVLWIWGIITKKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR5</accession>
    <name>W4THR5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67719">
        <property type="protein sequence ID" value="GAE67719"/>
        <property type="gene ID" value="JCM18909_798"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="298" mass="33496" checksum="CC94E5D8CCC2FBC8" modified="2014-03-19" version="1">MAAADGSSLDNPGPAGWAWYIDDDTWAAGGWPRGTNNMGELKAVLDVLRATRDADEPLTILCDSQYAINCCTKWIPGWKRKGWRKRDGKPVLNRDLLEPIDEELDGRDLTFEWVKGHAGHAMNEAADQRARAAATAFRDGTPVDHGPGFGRVDRDPQPQEDVPKPGNGDEQERLFDLLERPATPDQELIGILTDKERRFLETDAIVHRSALEELAAPDFIEHDGNGRLWTRGRALADMPVPEVRASIEILGMVRIGPQDVLLRWRARAGSRVSVRVSLWHRDPDRGWQLRFHQITPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THU2</accession>
    <name>W4THU2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68087">
        <property type="protein sequence ID" value="GAE68087"/>
        <property type="gene ID" value="JCM18909_1201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5611" checksum="48D559F426337B80" modified="2014-03-19" version="1">MSWMFMAFIPLSCFSVGGFYCLLRNDISGRFVSPALSSRLTRSRSGDRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI02</accession>
    <name>W4TI02_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="4" type="ORF">JCM18909_1722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68575">
        <property type="protein sequence ID" value="GAE68575"/>
        <property type="gene ID" value="JCM18909_1722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NDK" evidence="3">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15358" checksum="CF230783890A087D" modified="2014-03-19" version="1">MSDEERTLVLLKPDAVKRRLMGEIIGRYEAKGLTVRAMELSTIDAKTARKHYAEHVGRDYYAALEEFITSGPLVAMVLEGRRAISVVRAMNGTTDCAEALPGTIRGDFGMEKNHNLVHASDCLESAEREIGLWFPHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI18</accession>
    <name>W4TI18_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg(2+) chelatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68172">
        <property type="protein sequence ID" value="GAE68172"/>
        <property type="gene ID" value="JCM18909_1291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mg_chelatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Mg_chelatase_C" evidence="2">
        <location>
            <begin position="145"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26434" checksum="23EF0A1D5DCCA24D" modified="2014-03-19" version="1">MTRPPLAQPHHSVSMAAMVGGGARIAQPGAISLAHRGVLFLDEAPEFAPKVLDSLRGPLETGEIVIGRSQAHTTFPARFQLVMALNPCPCGLADDPSGRCTCTPQQVRRYSGRLSGPILDRVDVTVRMRPLTSAHLLDASALPAGESSAAVHERVAQARERAAARWRGVPWRCNAEVPGKVLRQMLQANDATRIIEDALTTGRLTARGVDKVLRIAWTVADLEGKDEVDKACVAEAMGMRRGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI72</accession>
    <name>W4TI72_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68456">
        <property type="protein sequence ID" value="GAE68456"/>
        <property type="gene ID" value="JCM18909_1595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8396" checksum="DCBBE88C68D501A9" modified="2014-03-19" version="1">MTLFFARRLVGEVLSVAQRLFARHQSLTSALTQAGGGEFDDLDLINEVMAGVLGAHDQRMIELGLEPKDAPRAPTASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIA6</accession>
    <name>W4TIA6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68496">
        <property type="protein sequence ID" value="GAE68496"/>
        <property type="gene ID" value="JCM18909_1638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8289" checksum="E119454EE101CE44" modified="2014-03-19" version="1">MMIVMTSTKLRSAPKALCRITTMRARKKRIAQVCVLACDFLPEVPLLPVTMSLGYVIDVSPRRTVEMEKDHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC7</accession>
    <name>W4TIC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68521">
        <property type="protein sequence ID" value="GAE68521"/>
        <property type="gene ID" value="JCM18909_1665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="400" mass="43418" checksum="6669D9E76A76A956" modified="2014-03-19" version="1">MTDIGRVLYACLVSRWPKGQGHRPFVEPATAMSWGLPPAPTDAHGWLTPREVRAGVSPVLDVLCDQILSRVPHYDEVPLRTANEIAQSLGRTLGSTDAAADLERRIHFPVGQTSRAEEDPWWSDESSVSVAPQDPDEPERAEEYGPDEEGYWSPEAAAGEWGRSPGPLPWSGRNDPHTTQLPPQDWSTDAEDEPVFAKARPHNRRWPPILVAVTAVVMVVCLIAAGMRHSDSGASQTSSNPTTVKLTHVQEFDPSEDGGDAKESHNQVKFAIDGNPSTAWHTVVYRNPAKLGNLKPGVGLVVDLGRATKVTSVKVRLVGSGTDISLWEPTHDVSSDQPPMKTIKEWTRVAAVTGAGKIVTLKPSENTKTRHLLVYLTELPAKSATRFQGGIVDITVVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TID3</accession>
    <name>W4TID3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68292">
        <property type="protein sequence ID" value="GAE68292"/>
        <property type="gene ID" value="JCM18909_1420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4710" checksum="02184E5D1FC1B58A" modified="2014-03-19" version="1">MNADPTPEVDHADLVAPLLSLAVWGSPRGEGWHCQHHCHRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TII6</accession>
    <name>W4TII6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inorganic diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67929">
        <property type="protein sequence ID" value="GAE67929"/>
        <property type="gene ID" value="JCM18909_1030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="PTHR10286"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="SSF50324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="14291" checksum="BF86D6DA4D1267A2" modified="2014-03-19" version="1">MTDDFTNPFQGEQPESLHFDVTIEIPRGNKNKYEMDHETGRIRLDRTLFTSTQYPYDYGYIEGTLGEDGDPLDALVLLTEPHSPAASSSAAHWLCSRCKTRWVATTRCCACLPMTPAVPASSTLTMSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN2</accession>
    <name>W4TIN2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68288">
        <property type="protein sequence ID" value="GAE68288"/>
        <property type="gene ID" value="JCM18909_1412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="300" mass="31843" checksum="A0F1413A85E8E1DA" modified="2014-03-19" version="1">MDFSGAIGKELFVGFFIAFAIKAPMVPVHTWLPDTAEQATAGASSLLVGLLDKIGTFGMLRLCLGLFPAASDWATPFVLTLAIISVLWGAMMAATSSDLMRFVSYTSVSHFGFMVIGIFALTTTSITGSIFYMFNHGFSTAALFLVLGFLVRRGGTTKVDGYGGVQKVAPVLAGTFLFAGLATLSLPGTGNFVSEFMALAGAWSRHPIYVAISTIGMVLAAVYVLVTYRRTMTGPVQGVSEQVSDLNGREKLVLAPLIILLLVFGFFPRPMLHAIEPAATATMTQVHATDPAPVVKEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ6</accession>
    <name>W4TIZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Galacto-N-biose-/lacto-N-biose I ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1645</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68502">
        <property type="protein sequence ID" value="GAE68502"/>
        <property type="gene ID" value="JCM18909_1645"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21476" checksum="F6976B48C98C1CC6" modified="2014-03-19" version="1">MPEISPFAGHLSFSLLSSHVILASMANMTTWTFTGYNMLIFLAALQAIPSDLYEAARIDGASGWEIMTKIKIPMVRGAAMLAVLLSIIGTVQLFNEPTVLATVATWMPRDYTPMMMAYNTMNGNISPSGAGPASAVSIMMALVAGGARNDLRPGPEEGGLTWHTARPPSPRMASLTAPHWMVSLLDRLPPPRRPGQSHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ13</accession>
    <name>W4TJ13_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68781">
        <property type="protein sequence ID" value="GAE68781"/>
        <property type="gene ID" value="JCM18909_1938"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="627"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="858" mass="94075" checksum="B7BED4ED24DBA82E" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ30</accession>
    <name>W4TJ30_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribulokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68547">
        <property type="protein sequence ID" value="GAE68547"/>
        <property type="gene ID" value="JCM18909_1693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="215"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="493" mass="53399" checksum="235DE7CE82122070" modified="2014-03-19" version="1">MKDAGVDPDHIVGIGLDVTSATVVAATKDGTPLCQLPKFRNEPHAWVKLWKHHGAQDQADRIVKLAQVRREPWLTRYGGILSSEMLMPKVLETLERAPQVYRAADVFCNVVDWLTWRLTGVLTFSAGDSGYKRMYQDRTYPSRDYLMNLNPEFADVFAEKMNAPVLPLGARVGGLTSEFSERLGLPAGTTVASGNIDAHVTAAAVQAVENGQMTAIMGTSACYVVPGPQLKEVPGMFGVVDGGIVDGSWGFEAGQTAVGDIFAWFIDNCVPGSYVDEADHRGISVHDLLTEKCARQEVGAHGLIALDWHNGNRSVLADANLSGMILGQTLTTTPEDQYRALLESTAFGARTIIESFRDSGVEINELVVAGGLTKNTFLMQLFCDICRVSLSVGTIKQPGAHGSAVFAAVAADLYPDVKAASAAMGAKEAGVYQIDEQRAEQYDALYAEYARLHDYFGRGGNQVMHRLKEIRRQAHLRARESTEPSNGGNGAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ86</accession>
    <name>W4TJ86_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69010">
        <property type="protein sequence ID" value="GAE69010"/>
        <property type="gene ID" value="JCM18909_2190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11557" checksum="20072D7AA034A810" modified="2014-03-19" version="1">MAAIDNGNGPVKLTGESAGKAVSAAKVVGQSHDLQLELQYKNTPAGVYPAVLVTYEIACSKGQDSGKAALLKDFLSFYASEREQKKIQDLGYAPLPSDVASKVLGSAQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ88</accession>
    <name>W4TJ88_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-arabinose transport system permease protein AraQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68224">
        <property type="protein sequence ID" value="GAE68224"/>
        <property type="gene ID" value="JCM18909_1346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27849" checksum="9B7586EE7DEFBFAB" modified="2014-03-19" version="1">MTGTALPDEVRGDATVPGGTLADVPQRRRRRTAAQQTMSAVRYVLLVIFAVLVLTPAYALLVTSFKMPSGYDQTTAWKLPRVWSVGGWQAAWDALAPALGRSLVMAVLAAIISAILGSLNGYVFAKWKFPGSHVIFVLFLFGMFIPYQAIMIPLSGMMLDIQQGAPWFAGIPTLVLVPRRVWHPHLHSDLPQLLRDRSALGHSRGRQSGRRCHDLDVHQDRPTGVHPRLRRDAHLAVHQCLERLPLRAVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA1</accession>
    <name>W4TJA1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68617">
        <property type="protein sequence ID" value="GAE68617"/>
        <property type="gene ID" value="JCM18909_1764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="23388" checksum="37FAA6CA8C2A2E9C" modified="2014-03-19" version="1">MMIRARDVTFCYGERRILDGINLDVQAGEFVGLLGPNGAGKSTLLSVLCGDLEGWQGTVELDGAPLQQLSRPQLALRRSVMPQFSEFPFSYLVHDIVMMGRSPHPRGPDDAVIVDRAMERTEVTDLVDREVTRLSGGERARVTLARVLAQQAPCVFLDEPTAALDICHQERTMAICHELADAGCAVVAVMHDVALAAACCDRIALLSGGKNTGRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJE8</accession>
    <name>W4TJE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68901">
        <property type="protein sequence ID" value="GAE68901"/>
        <property type="gene ID" value="JCM18909_2073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6631" checksum="4DF694058562889F" modified="2014-03-19" version="1">MILPGVGRKTANVVLGNAFGIPGITPDTHVMRVSRRLGWTDATTPAKVETDLAELFLTRPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI6</accession>
    <name>W4TJI6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68926">
        <property type="protein sequence ID" value="GAE68926"/>
        <property type="gene ID" value="JCM18909_2101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22026" checksum="D4DD798D909E1330" modified="2014-03-19" version="1">MLPPFVSGSPSTPPTDAMAVRDPLESDRVKANTTAPTHTANSVPTTADQRITVPKTSEYPSSHMNSEEDPVTSMRECCRRSPSFAVGVCGNRNHTVVDWVFTLSGLTPSTLAAVLRLMRLGRPYPRAWWGAWMAGSTVVPVLSRPSLLEMMACETRVASGENSTTPSSRAFITLPSPQSAAHTEYHRRWPPSTTSLRTTSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJN9</accession>
    <name>W4TJN9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphotransferase system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68991">
        <property type="protein sequence ID" value="GAE68991"/>
        <property type="gene ID" value="JCM18909_2170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9011" checksum="78A204F6B94C678E" modified="2014-03-19" version="1">MPSRTTTIAAESGLHARPAAMFVQAASKSGLAVKIGRPGEEPVDARSILSVMGLGAKHGETVELTAEGDNADEVLDALVANLQTDPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ2</accession>
    <name>W4TJQ2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68658">
        <property type="protein sequence ID" value="GAE68658"/>
        <property type="gene ID" value="JCM18909_1809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="22602" checksum="DB275984A6AF46D3" modified="2014-03-19" version="1">MTAHDSSTTDPRVVESEIAKEQAHVDRVRAQLEIDENKARMLAKAGQDMYRSDRTSWVREEDGTAMFERDAFSYNAAKRLAVLDAEHEGLVFGRLDLTDDEVRHIGRIGVRDADYEPLVIDWRARAAEPFYRATPSDPMGVVRRRVLRCRDDKVLGIEDDLLDSTSQANLPIIGEGALMRLSLGPATLECIQSSRRSSRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR5</accession>
    <name>W4TJR5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TOBE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69026">
        <property type="protein sequence ID" value="GAE69026"/>
        <property type="gene ID" value="JCM18909_2207"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="TOBE" evidence="1">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13703" checksum="F05053397A721085" modified="2014-03-19" version="1">MAALLGVSDDTVRRWIDQRHVRAAKDTTGRLRVDGASLAAFLVTQQQERQDLADGVQTQSMRNHIRGIVANVVSDKVMSQVELVTGNLSIVSLVSTEAVRELGLQVGSIAVAQVKATNVSLQLPVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW3</accession>
    <name>W4TJW3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68723">
        <property type="protein sequence ID" value="GAE68723"/>
        <property type="gene ID" value="JCM18909_1877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="37"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="216" mass="22931" checksum="09416AEB16240249" modified="2014-03-19" version="1">MTTVMPDLPPVDVPQTAVDDAPTKISTWTIAKQNSKVLWTTGLGVTALMVVRSARRSLLPLWCHANGLSPATTDLIYAWSMAADVLLFLPGGALMDRFGRWWVAVPSIFIQALALLTLPLAHTATTIGIVALIIGIGNGASSGIVMTLGSDASPNIGRPQFLAAWRLLSDTGSAMGPIVVTLVTLAWPLSAASIVMSIISLVGSYWMGRWVPRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJW6</accession>
    <name>W4TJW6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68827">
        <property type="protein sequence ID" value="GAE68827"/>
        <property type="gene ID" value="JCM18909_1991"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021400">
        <property type="entry name" value="DUF3039"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11238">
        <property type="entry name" value="DUF3039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8388" checksum="2C3313C2E8B643DB" modified="2014-03-19" version="1">MAPGSSTAVEEKTRPSFDDGDAERFSHYVPKAKLTDAMVNGTPVVALCGKVWVPSRNPEKFPVCPECKEIFESMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJZ2</accession>
    <name>W4TJZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2',3'-cyclic-nucleotide 2'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69116">
        <property type="protein sequence ID" value="GAE69116"/>
        <property type="gene ID" value="JCM18909_2304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9012" checksum="09840AA308D43099" modified="2014-03-19" version="1">MHDNPLGTNLSHRALLAGSLGAGLAMTAVDRSLALPTPTVSDSTPSTAALTVLATTDIHGHVFDWDYFADAAFPPSDKGVLRLPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK73</accession>
    <name>W4TK73_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein HU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68833">
        <property type="protein sequence ID" value="GAE68833"/>
        <property type="gene ID" value="JCM18909_1997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9588" checksum="3FCA052D66AB9329" modified="2014-03-19" version="1">MTKSELIKTVAKQASLTEAQTNEAVKALTDVITAALAKGEKVQLPGLFTAETVERPARNGRNPRTGESMTIPAHKAVKISASSTLKKAVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKE3</accession>
    <name>W4TKE3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68624">
        <property type="protein sequence ID" value="GAE68624"/>
        <property type="gene ID" value="JCM18909_1772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850794" evidence="1">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="11936" checksum="DB5C2C6E24F2423F" modified="2014-03-19" version="1">MTTSAMRKIVASVLGAILALAGVLITPAAWAAGPTVTVIPVGREGGDITISGKGFSTTGFGVYVAVAPASVTEFYGNSDKFYGYDPSKDTTESPSTIWSIPRVKKSYWLPVCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP0</accession>
    <name>W4TKP0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">JCM18909_2284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="W4TKP0"/>
    <dbReference type="EnsemblBacteria" id="GAE69097">
        <property type="protein sequence ID" value="GAE69097"/>
        <property type="gene ID" value="JCM18909_2284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13634" checksum="B3831068E2AF5F58" modified="2014-03-19" version="1">MPTIQQLVRKGRTDKISKNKTPALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLSSGIEVTAYIPGVGHNLQEHSMVLVRGGRVKDLPGVRYKIVRGSLDTQGVKGRKQARSRYGAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ5</accession>
    <name>W4TKQ5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bac_transf domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68998">
        <property type="protein sequence ID" value="GAE68998"/>
        <property type="gene ID" value="JCM18909_2177"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="113"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE68998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="321" mass="36479" checksum="06D5BCEB526EF8A4" modified="2014-03-19" version="1">MLLGPPEMLNRAVMNYMANKATRHRLTHVVRGHYLEQIRSHINEFDTAHVSDDIPSSERVAIYDLLLSEDKEIFMSTSFEHMMLINPTIMSIEDETIIAASPFKIPAEMDIVKRFFDILLSLIALVIASPIMFVTAILVKASSPGPVFYRQTRITKDGREFKILKFRSMGVTAEQESGPMLATTNDPRVTTVGKYLRSLRIDEIPQLINVLIGDMSIVGPRPERPFFVDQFQEQNAHYTLRHNVRAGITGYAQVYGKYASDFAAKLNFDLIYIKQYSLVLDVKIMIQTIKILFDKVSSRGVDETAEPDENIHLPAEVQQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ7</accession>
    <name>W4TKQ7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA_edit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69530">
        <property type="protein sequence ID" value="GAE69530"/>
        <property type="gene ID" value="JCM18909_2756"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6465" checksum="5667ED8CFD3525E3" modified="2014-03-19" version="1">MSGMEYGGITPVGLPAEWPIWIDPRVAEAEAVCIGSGLRSSKLIVSGGDVLSLPGAEVVAGLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKR0</accession>
    <name>W4TKR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaminyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69117">
        <property type="protein sequence ID" value="GAE69117"/>
        <property type="gene ID" value="JCM18909_2305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="1">
        <location>
            <begin position="55"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="30746" checksum="4885613A49C1410B" modified="2014-03-19" version="1">MDDPRMPTLRGMRRRGYPAAAIRAFCQAVGTTKNNSVKAIEEFESFVRRELNATAQRRMAVLHPLKLVLDGWPTDDDGNPVVEWFQLVNNPENPDDGTRRVPFTGELWIEADDFREDPPRKFFRLSPGHEVRLRGAYLVTATDVVKNPDGTIAEVHASYDPQSRGGTAPDGRKVKSTMHWVSAGHAIPVTVNLYDRLFSAEIPGSQTGEALDDLNPQSRETLTEVMAEPALANVAPGEVVQFERLGYFAADHDTAVFHRTVGLRDEWAQLQKRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKW5</accession>
    <name>W4TKW5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68804">
        <property type="protein sequence ID" value="GAE68804"/>
        <property type="gene ID" value="JCM18909_1967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="279" mass="31098" checksum="D4C25169B812E340" modified="2014-03-19" version="1">MRADLGLMKRHGVNAIRTSHYPPNARFLDLCDEYGVWVLLECDLETHGFERGGWDGNPTNDDRWYDCLLNRIQRTVERDKNHPAIIGWSMGNESHCGEGIRLMNDWVKNRDPSRFTHYEGDDAHAICDVWTVMYPSMEWVEAVRDRTVMPGAEPAPQTGRELGLPFFMCEFAHAMGNGPGELDAYEERCFDRTSTVTACMVDSSGSGSITASTLDVAMPTGATSVRSCTIQTSFVMGSSCPIALLLQPAGVYGDDGGGAHRGRRRAAARWQRHHRDQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX8</accession>
    <name>W4TKX8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68814">
        <property type="protein sequence ID" value="GAE68814"/>
        <property type="gene ID" value="JCM18909_1978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40570" checksum="9534443161A8E622" modified="2014-03-19" version="1">MSDEKYSAETGPGESRQFDRSYAPRTAEGLTDWTIPVIPSTRIDPEDWAWAHEQRKPVDPDIAVDQVAAILLVHQAAGWLPRALNALRRSGERAAVQIAVDLGSTDGSSDLLMAAVDEGLLDECVTASADTTPGEGINLAIDRLSDGVTHIWILHDDVEVRRDSLTCMLREASRKPHPDVLYPTLLKPARHNYPEFIDEQGQSVSTGGARVLPVVDRGDIDQKQADPGPILGGSTAGMFVRVDVWRRWVVSTRRFPFSVTAWILAGVPMKRAWWFALRRVAPFITVRRAEGGSESRIWLPVRMSPTVSRGCEWLQPGPVIPPARVWFSWWLACGVFSSLWWVRPPRVRSTSGGPACSCGGRAQLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ2</accession>
    <name>W4TKZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation elongation factor Tu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69108">
        <property type="protein sequence ID" value="GAE69108"/>
        <property type="gene ID" value="JCM18909_2296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP_EFTU_D3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="4935" checksum="59C61117E20C4C5F" modified="2014-03-19" version="1">MVMPGDNTDMTVHLIHPVAMEDQLKFAIREGGRTVGAGRVTKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL08</accession>
    <name>W4TL08_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 5">Thymidylate synthase</fullName>
            <shortName evidence="5">TS</shortName>
            <shortName evidence="5">TSase</shortName>
            <ecNumber evidence="1 5">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">thyA</name>
        <name evidence="8" type="ORF">JCM18909_2014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 5"/>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68849">
        <property type="protein sequence ID" value="GAE68849"/>
        <property type="gene ID" value="JCM18909_2014"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="7">
        <location>
            <begin position="3"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="171"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="269" mass="30753" checksum="BF90C7E5BDFB007A" modified="2014-03-19" version="1">MQIYLDLLRRILDEGVRREDRTGTGTVSVFGHQMVFDLREGFPLVTTKKIYTRSVFGELLWFLRGDTNVGWLHDNNIHIWDEWADENGDLGPVYGHQWRSWPDDGGTIDQIANVVEQIRTNPWSRRHIVSAWNVAEIKEMALPPCHTLFQFYVTPDDRGTPTWLSCQLYQRSGDTFLGVPFNIASYALLTHLVASVTGLKPLRFVHTLGDAHVYLNHLDQVHEQLTRKPRHRPTLTVNPGIRDIDGFELSDITLTGYDPYPALPAPIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL23</accession>
    <name>W4TL23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PaaD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69421">
        <property type="protein sequence ID" value="GAE69421"/>
        <property type="gene ID" value="JCM18909_2631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="156"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="253" mass="27456" checksum="49C4016BB9AE8E19" modified="2014-03-19" version="1">MTQVNPSCGDELLLRVHVDGDVITDVSYDAVGCLISQASTSVMTDLVIGKTIGEAQDLYRGFQEMMRSRGTVELDEDIYEDAVAFEGVAKLMARVKCAMLGWSALEDSLLKVTEGSAEKVGSGSGADMSEMKEKLMSEENALPAQEVALTAMPTVDDVIEALKDVIDPELMVNVVDLGLVYGVNIDDEGNVTIDMTLTSPTCPLTDRLEYDTQTVLEGIVKSVTINWVWLPPWGLERITDDGRAQLQAIGFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB5</accession>
    <name>W4TLB5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription termination protein NusB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69233">
        <property type="protein sequence ID" value="GAE69233"/>
        <property type="gene ID" value="JCM18909_2427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7974" checksum="BD25CAD4B744EF1D" modified="2014-03-19" version="1">MDTTSGNASDPENSADDFELTDGEHPTSKDHELATDLHKKRTQPTTKRTNVPIVSIGSPVETITRCRAEALHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB6</accession>
    <name>W4TLB6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69536">
        <property type="protein sequence ID" value="GAE69536"/>
        <property type="gene ID" value="JCM18909_2762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8275" checksum="E5F9E55BF41C4329" modified="2014-03-19" version="1">MFPHDADLGHRSRASCSPGRLGQLWRNAGADVVEINAWNHPVPPIVDADALVVLGGSMSCQDDAEAPCSRPPASSSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLC8</accession>
    <name>W4TLC8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative 3-methyladenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA glycosylase MPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69243">
        <property type="protein sequence ID" value="GAE69243"/>
        <property type="gene ID" value="JCM18909_2439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003905">
        <property type="term" value="F:alkylbase DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00540">
        <property type="entry name" value="AAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00527">
        <property type="entry name" value="3MGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003180">
        <property type="entry name" value="MPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036995">
        <property type="entry name" value="MPG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10429">
        <property type="entry name" value="PTHR10429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02245">
        <property type="entry name" value="Pur_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00567">
        <property type="entry name" value="3mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20369" checksum="1FE9255926566CB6" modified="2014-03-19" version="1">MIDLSAPAIEVAPLLLGATIWRGPVGIRLTEVEAYMGLDDPASHAFRGPTPRARVMFGPPSHVYVYLSYGMHRCVNLVCSPDGEASAVLLRGGQVIAGHDDARRRRGNVAENRLACGPGNMGSALGASLEESGNPVSIIGNGAISALGWRLEPAPEIAEFRQGPRVGISRNVDAPWRWWVPQDPTVSGPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG0</accession>
    <name>W4TLG0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major myo-inositol transporter IolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69581">
        <property type="protein sequence ID" value="GAE69581"/>
        <property type="gene ID" value="JCM18909_2815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15271" checksum="19D5B4A7514C629B" modified="2014-03-19" version="1">MSLSLFGLALIFGVGIAPYIKADGSISSSIPNYLPWMVVVLVSVFVFMKQSGTVNWILVSEIFPARIRGVAQGVAVGALWCMNAVVTFAFPSMIAHLGPAWTYTIFGCINVCALIFYIKVVPETKNSTLEEVEATLLAKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG5</accession>
    <name>W4TLG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inosose dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69586">
        <property type="protein sequence ID" value="GAE69586"/>
        <property type="gene ID" value="JCM18909_2820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12740" checksum="38DAFAAED936FAB0" modified="2014-03-19" version="1">MAEAGFEIIETGPYGYFPTDPKELQKWCDEFGMRVVAGTGWGILHKPEAWETTLKTFRAIAETHAAVGAEYIVHLPPLYRDDKTWEWTDDRVLSDDAWKLYVEHANALADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI1</accession>
    <name>W4TLI1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphate transport ATP-binding protein PstB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69014">
        <property type="protein sequence ID" value="GAE69014"/>
        <property type="gene ID" value="JCM18909_2194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="2"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="236" mass="26242" checksum="DF86FF0CDCAB4E0E" modified="2014-03-19" version="1">MLRTLNRMHEVIPGAYCTGKVELDGVDLYGKGVDPVAVRRNVGMVFQRANPFPAMSIRDNVVAGLKLNGVRDNKLLDEACEKSLRGANLWDEVKDRLERSGASLSGGQQQRLCIARAIAVEPEVLLMDEPCSALDPISTLAIEDLVSELKERFTVVIVTHNMQQAARVSDQTAFFNLKAQGEPGRLVEIDTTERIFSNPKEKKPLKITSRAASAERPRQLHHTAAFQPAWQRMSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLK9</accession>
    <name>W4TLK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Citrate lyase beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69631">
        <property type="protein sequence ID" value="GAE69631"/>
        <property type="gene ID" value="JCM18909_2871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="26637" checksum="949C3DDBDC3DA27C" modified="2014-03-19" version="1">MPGANARALEKARSIDCDGIIIDLEDAVAPDLKVEARERAAGVVKEHPYGYREVAIRVNGMDTQWYRDDLAAAVAAGPDAIAVPKVGSAEQVRSIVSDMEAAGADESVKLWAMIETPQAVLDCRDIAEASDRLTVLIMGTNDLTKELRASHVPGRAPVTTALQMCLLAARAADVVILDGVYNDVRDVEGFTAQCREAQLMGFDGKTLIHPGQVGPANEVFAPDAEQVAEARGIIDAWESGNGSGVVTYHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLM6</accession>
    <name>W4TLM6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69651">
        <property type="protein sequence ID" value="GAE69651"/>
        <property type="gene ID" value="JCM18909_2896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10078" checksum="4B271E53653E388F" modified="2014-03-19" version="1">MTTSDVPAIGWHDAVAQAVSTHPWLAHLTAIDGAGERGQDPDIIVVCRLENHDGDDVTVSTRVPRDGGTLDSIVDVLAGASWYQREIHDFFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS2</accession>
    <name>W4TLS2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PreQ0 transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69457">
        <property type="protein sequence ID" value="GAE69457"/>
        <property type="gene ID" value="JCM18909_2673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12141" checksum="761A49D0E77C10B1" modified="2014-03-19" version="1">MRISGWTVYELGYHDSTQGQVLERGLVGRLMGSTGAGEAVDTIIFCAIAAPVVGITSFGQWCNYAFFGFLWKTLVEYACIPVTTRIIAWIKKTRAELSGKAGSGPELTRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU7</accession>
    <name>W4TLU7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69487">
        <property type="protein sequence ID" value="GAE69487"/>
        <property type="gene ID" value="JCM18909_2707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="59"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17741" checksum="49139C4571B611B2" modified="2014-03-19" version="1">MMRTLYKDPDRYLETYWMKYPGVYLTGDSARIDDDGYIWIIGRTDDVIKVSGHRIGTAEVESALISHPAVAEAAAIGLPHEVKGNAIHMVVVLNHGFEPTKNLVSDIRGHVAETLSPIAKPDTIEFVDKLPKTRSGKIMRRVLKARALGEDEGDLSTLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV7</accession>
    <name>W4TLV7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69497">
        <property type="protein sequence ID" value="GAE69497"/>
        <property type="gene ID" value="JCM18909_2718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10619" checksum="B6AE56FD1FBBAD7D" modified="2014-03-19" version="1">MSLGVRESELVKTLEDEPWHAKLWHQRRLGRSVRLPIAYDAGPGQIGDTVRDIPLSFSPERREYGWRDVTTTTIVVDNPNGSDEPDWFAGLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM12</accession>
    <name>W4TM12_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epi-inositol hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69567">
        <property type="protein sequence ID" value="GAE69567"/>
        <property type="gene ID" value="JCM18909_2800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016823">
        <property type="term" value="F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030817">
        <property type="entry name" value="Myo_inos_IolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF9">
        <property type="entry name" value="PTHR18968:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="88"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26463" checksum="26BAF2B041BFF8B9" modified="2014-03-19" version="1">MGSFDAAKQGAQMLVADAREALTALSKELDGYRVPQEWSDLASAKAKAWAEVTDRCYHLGHGPLPAQTEAFGALNELMGDDDVVINAAGSMPGDLQCLWRASTPVQYHVEYAFSCMGYEIPASLGVKMALPDSEVVAIVGDGTYQMLPMELATIVQEGAKVILVLLQNYGFASIGALSESHGSQRFGTKYRQHDDGQGHVSGTTPCYPLTLPLTRGRGVLMSSRFVPSRSSGRLTARPRRLIMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM14</accession>
    <name>W4TM14_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription termination protein NusB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69234">
        <property type="protein sequence ID" value="GAE69234"/>
        <property type="gene ID" value="JCM18909_2428"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB" evidence="6">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11411" checksum="2796F3818E8B487B" modified="2014-03-19" version="1">MRPFAADLVRGVAATQVGLDSVLTDCLSEGWTLARMPRVDRILARLGAFEILHTDTPNPAVISEAIELSEEFSTDDSAPFLNGLLGAVITHGPARVEDQRPTTQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM36</accession>
    <name>W4TM36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lead, cadmium, zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69254">
        <property type="protein sequence ID" value="GAE69254"/>
        <property type="gene ID" value="JCM18909_2450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="200" mass="20675" checksum="45F2EDF641526DE5" modified="2014-03-19" version="1">MLVVGRGDDIVGAIAVSDEIKPEAVVAVKRMVQAGVRPVLVTGDNSGAAARVASELGIGEVMSEVMPADKVEVVTQLRSDGARVAMMGDGVNDAAALQTADLSIAMGTGTDVAIAASDIICTRGDPRLAVDALSLAHATDRTIRQNLFWAFAYNVIAIPVAAGGLLSPVIAAAAMAFSSIFVVTNSMRLVRWHPEMSDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD1</accession>
    <name>W4TMD1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">K+-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69349">
        <property type="protein sequence ID" value="GAE69349"/>
        <property type="gene ID" value="JCM18909_2555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="4015" checksum="8C5FDC74F8123605" modified="2014-03-19" version="1">MREGGRCAMTILNLVAAILGIAAVVYLVIALIRPERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMF6</accession>
    <name>W4TMF6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-isopropylmalate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69896">
        <property type="protein sequence ID" value="GAE69896"/>
        <property type="gene ID" value="JCM18909_3162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="38" mass="4033" checksum="FF7958C0097AE230" modified="2014-03-19" version="1">MESHRRGFFDDSTLAEIAQEDAIVLGAVGATPDSTEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMV0</accession>
    <name>W4TMV0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic copper homeostasis protein cutC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69743">
        <property type="protein sequence ID" value="GAE69743"/>
        <property type="gene ID" value="JCM18909_2992"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16537" checksum="D1351F5E5B456328" modified="2014-03-19" version="1">MASVYRDLGADGPVLGFLDEATGVDVETVIELTEGCQRWTFHRAIDNSLEPDKAWAQLLGLHGLDQVLTAGSPRGVEHGLDDLIARASADPRVADLMMAGGGLRAEHVPWLYRAGVRAFHIGSPARPQGSWKAWVDADLVRSWRDLLDRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMV1</accession>
    <name>W4TMV1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsB</name>
        <name evidence="5" type="ORF">JCM18909_3130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69867">
        <property type="protein sequence ID" value="GAE69867"/>
        <property type="gene ID" value="JCM18909_3130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="284" mass="31680" checksum="8D84FA225ED8A1AA" modified="2014-03-19" version="1">MAVVTTRQLLESGVHFGHQTRRWNPKMKRFIFTERNGIYIIDLHQSLTYIDKAYAFVKETVAKGGQILFVGTKKQAQESIVEQATRVGMPYANQRWLGGMLTNFQTISKRIARLKELEAMDFDKVSGSGLTKKELLMLSREKDKLEKDLGGIRDMPKVPQAVWVVDTKKEHLAIDEARKLKIPVVAILDTNCDPDEVDYAIPGNDDAIRSVSLLTRIIADAAAEGLMARSAGKSGEQPAEAEPMPDWERELLEGDGAKPEDKTEAKAEEPKAEAKKADEAEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN45</accession>
    <name>W4TN45_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acylglucosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="4">5.1.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70395">
        <property type="protein sequence ID" value="GAE70395"/>
        <property type="gene ID" value="JCM18909_3713"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11232" checksum="84F82B2F4F21C5C6" modified="2014-03-19" version="1">MSGFTDRIIASMAGGLVVSCQAYPGEPLRHPETMAQMAAAVEAGGAVAVRAQGLSDVSAVKGRVSVPVVGIWKEGDEASTSPRPCAMHAAWQLPGLTSSPSMAPDANVPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK9</accession>
    <name>W4TNK9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70321">
        <property type="protein sequence ID" value="GAE70321"/>
        <property type="gene ID" value="JCM18909_3635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="236" mass="25140" checksum="A0AB62C2DD06B22C" modified="2014-03-19" version="1">MNEPQAARPTQHVSEKALEDLDHNAIEPPPVPRHDIPEGAGKVVFVGAGPGAPDLVSVCGARVIETADIIIWLPAWYIPTWLLGTRRALSSSTPPPSPWRTLNPSTPVPATRVWWWPGSTPVTRPSTGLPQNSVTCVVVLVLTSRPFLASLLSRPPLHGWTSRSLSRKSLSHSSSPGSRAGARPCPMVRPLPPSPAMGRLWQSTVSGPKQGASGGFTRGRISAGDSLHHRVCGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM8</accession>
    <name>W4TNM8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE69998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69998">
        <property type="protein sequence ID" value="GAE69998"/>
        <property type="gene ID" value="JCM18909_3276"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16949" checksum="E41741BF71E6FBEC" modified="2014-03-19" version="1">MDKLTSFNGILLTQAVRHPKAIHLPSNAAEAFIQFKNPLANGVCTDPAVIEDYKKDPLNNKYMSLGMVKQMGVAQVYNTFNAPSFTEPTLIMHGANDGIVPSYFDVNWYNAIGSKDKKIIEWEGLMHETINEPVKDQVDDTIINWINAHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR6</accession>
    <name>W4TNR6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70182">
        <property type="protein sequence ID" value="GAE70182"/>
        <property type="gene ID" value="JCM18909_3479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16689" checksum="C2FA31AC73736178" modified="2014-03-19" version="1">MWIILGSAVACGLALWHLRVTVPNLVEPTVEEVGDAALAIKLTYTSLTTPTRTFVVAVTAAVCGAASVCAPPWAWGVWWIWSGSVTTLVIVDYATTFLPLKLWRRCVAEAGVALLRNRPDTAATCTVARCVCSDPGSVNRILLAHVATQFIPRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW5</accession>
    <name>W4TNW5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-2-oxoglutarate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70098">
        <property type="protein sequence ID" value="GAE70098"/>
        <property type="gene ID" value="JCM18909_3388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="188" mass="19715" checksum="E6A34BC95C0B4FC0" modified="2014-03-19" version="1">MSAEVDDSGRTDDRLTFPDEVVAGKIIAVLPDVPAADLMAPVEAMIQEKVRVFFALPVADAERRRAVLRIYRRRAVVGVHGVMTIEDVQGLVDDKVSFALPVAANREVLDALRQAGIPAAPDALTPNEVRAAWGAGADAVQVAPADMGSASYGDILTRMAPGAALIPRGGVGSYALRRWLAAGACGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX1</accession>
    <name>W4TNX1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-acetyl-D-glucosamine ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_4051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000064">
        <property type="protein sequence ID" value="GAE70675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70675">
        <property type="protein sequence ID" value="GAE70675"/>
        <property type="gene ID" value="JCM18909_4051"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="292" mass="31728" checksum="06BDAFEF2E2136AF" modified="2014-03-19" version="1">MGGAGPFAALCILPALVLYVLFLVYPTLNVFRMSLFDWNGLGNAPSFIGLDNFAALIHDPAFVRAFENTLFILVVVTIVTIYSSIFIAAVLTRETLVGAGWYRFVLYLPSVLSIVVVAAIFSAVFDQNNGLVNGLLQALGLGHGPVWLGDQNVVMYSVAIAMVWQSLGYYVVLYMAGMSSVPVEIYESASLDGAGRMTQLGSITIPLIWSNIRTTLTFFVLSSVNLAFVLVKALTDGGPNGSSEVLLDYMYKQAFTNSAYGYGMAIGVVTFLFSFLVAMLISHVTRREVLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX9</accession>
    <name>W4TNX9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bis(5'-nucleosyl)-tetraphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69904">
        <property type="protein sequence ID" value="GAE69904"/>
        <property type="gene ID" value="JCM18909_3170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9157" checksum="7BC0580BE876B96F" modified="2014-03-19" version="1">MDCLFCSIAAGDIPATIIDSDDASVAFLDIEPFQDGHTLVIPRRHVTSVLDDDGELGRISDGHQGGSSPRGLSGGFWSQCRLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP16</accession>
    <name>W4TP16_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70282">
        <property type="protein sequence ID" value="GAE70282"/>
        <property type="gene ID" value="JCM18909_3589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="231" mass="25019" checksum="3B0F8BD5CCC9621B" modified="2014-03-19" version="1">MKLFSSGRKTPTSSPASSHAGAMDETVGVTSTSEAANVATQPVPTPVEDVPNGVRTAAGWCWRMIVIAAFIYGLYQVLHAASEVSVPVAVALMLTAAMWPLANWLSRHHIHRGIASGICLLFLVILVGGVFTLVGARSLCSGVSWGTKVSLASNRLCSGWPRALCTPMRLNLPTSCRSRGSHGRLSRAHRLDCSCCRFPDWAVRRRSRNGAVCNVLFSSTRATNWPRNRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP67</accession>
    <name>W4TP67_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper-containing nitrite reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70203">
        <property type="protein sequence ID" value="GAE70203"/>
        <property type="gene ID" value="JCM18909_3501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="300" mass="32597" checksum="E19C36AABC769FC2" modified="2014-03-19" version="1">MPEITSAPVGRKPDTNKRSWHRKASRPVSGWLVALLIVAVANPWIPQSRWLLVHMVTLGVATTSIMVWGQYFTEAILHNNLTDTDRSRQVLRIRLLTVGIVITCIGMVVTWPWMTVTGAAVIGSMLTWYAFALGCQVRHALPGRFDSTVWFYCAAACLLPLGATLGAIMAFSPTEPWRTRLLVAHQALNLLGFVGLTVVGTLITLWPTVLRTKMQSAQDRHGKISLYVMLVAVAATTAGALCGLWWLAALGVTATSSESVSCWATWWPALSTDRRATSPGSPWGPLSAGCWCGSSGWHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP71</accession>
    <name>W4TP71_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">6-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_3641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70327">
        <property type="protein sequence ID" value="GAE70327"/>
        <property type="gene ID" value="JCM18909_3641"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE70327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13776" checksum="042387587AB2395E" modified="2014-03-19" version="1">MIAGLVGSIDNDLVGSDMTIGADTALHRIVDAIDDLASTAASHQRSFVVEVMGRHCGYLALWQQLPAGLTTFLFQNGRPRTVGRTHVRRAQTWPSGGSTRLDRRRRGGRHRSFREPDLLGVRPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP76</accession>
    <name>W4TP76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE69999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69999">
        <property type="protein sequence ID" value="GAE69999"/>
        <property type="gene ID" value="JCM18909_3277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849348" evidence="2">
        <location>
            <begin position="32"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="288"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="498" mass="52420" checksum="8F6549EF00F6DE8F" modified="2014-03-19" version="1">MLPKPNLPLRVTAIALTTCLALSACSSHGDAKNPSQSDSSSTAGASNAALAKIPAAQAGATDITFNAAPEKVKAIFPRFAKARNLSTAVEVVKGRMLRDSWQQNASDVNVTSQIIASNDAALGVLVTNQTTIAGKKQTIPATIWYSTAAQQSYSSPALIKPDKWADLTTALQDAGKDQSLDGGKKIAAAVKAKSAPYGSGPALGFSHNGDLLASFASGVVTDKAVTLVVPSDKAKGMLSNFGAQAQKASTNPGTFTGTTSQPVDESPKATDTSGRPSTAVGPDCRVLHCVAVTYDDGPSAMTPELLNTIKKLKLSITFFEMGNSIMAFPNTAQKVAAAGMEIGNHTVTHPNLPAKTPDRIRRELEHNSQLIKQLTGATPLLFRPPYGAHNATVDKVAKDNGMAIIQWQIDSEDWKNRNPEMTYKNVMTALPYTAPIVLEHDIQKASIDAAPQIYKDLEAKGKTIVSVSELSLNTGGYQAGHAYCNGTVKPQSGYNCKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPB3</accession>
    <name>W4TPB3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70248">
        <property type="protein sequence ID" value="GAE70248"/>
        <property type="gene ID" value="JCM18909_3551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5658" checksum="8052125CD83436A5" modified="2014-03-19" version="1">MSILGKTSVGVFASIGGTILFIEAVSVLTTKRGIIGKLMHVNLVDARCITPQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM6</accession>
    <name>W4TPM6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">JCM18909_4069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000067">
        <property type="protein sequence ID" value="GAE70691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70691">
        <property type="protein sequence ID" value="GAE70691"/>
        <property type="gene ID" value="JCM18909_4069"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE70691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="121" mass="12842" checksum="88776498BDA2E672" modified="2014-03-19" version="1">MLGTLIRSVIAHAWPPRADGVPWGTLVINLVGVFVLATLLELLVHAGPDQGVRRAVRLCIGTGLLGGFTTYSALTVETGQRVMSGQWLWGIAYLLTSVVAGALLAWVMIAAVRCVMGKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPR0</accession>
    <name>W4TPR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70393">
        <property type="protein sequence ID" value="GAE70393"/>
        <property type="gene ID" value="JCM18909_3711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20016" checksum="75A3490D1F20C84C" modified="2014-03-19" version="1">MTPINDTTSTNNTKDNTMTTKFHGVISPVVTPLTPNGDLDVASYEKLINRLIGQGVDGLFVLGSTSEVAFFDDEMRGRVLSEAKRIIDGRVPLLAGVIDTETLRVIRHIGQAEEIGVDAVVATAPFYAITGPTEIENHFRALHEATDLPLFVYDIPVCARQGARRPHDEVGTRGGHRRLQGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPT3</accession>
    <name>W4TPT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylamine-glycine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70403">
        <property type="protein sequence ID" value="GAE70403"/>
        <property type="gene ID" value="JCM18909_3721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GARS_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11154" checksum="77A21A645A8F02A4" modified="2014-03-19" version="1">MSSMTILVLGSGGREHALALACHRDPEVAAVHVAPGNPGTASFATNHPLDPCDCDAVVSLARGLEADLVVVGPEAPLVAGVADALRESGIDCFGPSAEAAQLEGSKLSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ25</accession>
    <name>W4TQ25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70483">
        <property type="protein sequence ID" value="GAE70483"/>
        <property type="gene ID" value="JCM18909_3810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="76"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="215" mass="22221" checksum="796869BF22EA17CE" modified="2014-03-19" version="1">MCCRELTKWGIDLTPSPINPGWTLPVTMSQACGTERAMATVETALPAPLPAPNLDGVDVIVTHVSVPADAWLHDAADAGIPVIADHGFEEEYEPGLLDAVSGCTCYTPNAAEAMHLTGADDPVRAARALAERVPVVVVTCGGDGIVGVDSRTGEEVHVPAVNINPVNTTGAGDAALAGLAWCWGWQVPLACKLDVAAGGGYCHLASARNCRPPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ43</accession>
    <name>W4TQ43_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA double-strand break repair Rad50 ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70349">
        <property type="protein sequence ID" value="GAE70349"/>
        <property type="gene ID" value="JCM18909_3663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="304" mass="33544" checksum="E832FAA07A0DC40E" modified="2014-03-19" version="1">MKLHRIHVENFKAIDERTLELPDCGVVIATGRNEIGKTSMMEALDLLLDTGTKASSKSRKVRTAQPYGTSLQVVVEAEMTIGDHRFVHRKCFLKDKESSLKFLAGPRAGQTITGDEAVEMMETLLSGADVTLWNALRLMQANGLSPLRLDSSQALTAALEQAGGQQPDEGSGGGLMDRARAEYDKYFTPGGSERRSVFADRDELEEIRSNLAKGQERLAEVDEVVDSLSRINEQISHDQTVVASKKVRLSESRSCPCEPHRPRERGRDRQTYCQGSSAASCRGQNGPRYEGQAHRRSRDGPGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ52</accession>
    <name>W4TQ52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70513">
        <property type="protein sequence ID" value="GAE70513"/>
        <property type="gene ID" value="JCM18909_3843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_N" evidence="3">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="264" mass="28416" checksum="6338126028524B49" modified="2014-03-19" version="1">MDEINKGNEPFPGEAFLDEKLKKLVPAGKLTATTDYSQAIPGADAIVLVVPLFVNDETWEPDFGWMENATKSLAEHLTPGTLISYETTLPVGTTRNRWKPMIEEISGLSEGKDFHLVFSPERVLTGRVFADLRRYPKLVGGLNDEALPRASTSTSKFSTSTTVTTFLAPTASGTWAPLRLLRWPNLPKPPTVTSISAWPISSASTLRPTASTSTRSLTPATRSPTPTFTVPALPSEVIASPSTRASTCGPIRTPPSSALPARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQD6</accession>
    <name>W4TQD6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70618">
        <property type="protein sequence ID" value="GAE70618"/>
        <property type="gene ID" value="JCM18909_3972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022506">
        <property type="entry name" value="Metallophosphoesterase_PPA1498"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03767">
        <property type="entry name" value="P_acnes_RR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="62"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="540" mass="59475" checksum="3643D0C53B25C803" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQJ8</accession>
    <name>W4TQJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerol-3-phosphate regulon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_4059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000065">
        <property type="protein sequence ID" value="GAE70683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70683">
        <property type="protein sequence ID" value="GAE70683"/>
        <property type="gene ID" value="JCM18909_4059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="168" mass="17632" checksum="5320CAFA903889C5" modified="2014-03-19" version="1">MSKKEGVLRGGPRARQFAIAEAVVRAGSVSVEDLVESTGVSAMTIYRDLASLESSGVLQRHRGRVVAVANGLHEADAAFRLEQSSSDKQAVAELASGLIAPGSSIMLDDSTSGVWVLRSLPEHTPLTVVTNSLLVAKEVITTSSDKLVVTGGEYQSWAQSSWGPPPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQL8</accession>
    <name>W4TQL8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70524">
        <property type="protein sequence ID" value="GAE70524"/>
        <property type="gene ID" value="JCM18909_3857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8094" checksum="420546556A78C4BF" modified="2014-03-19" version="1">MGMMNHLHSKAHLLHLGADSVVAQTAPTTFDVSIWQFCSALLVGGAVRIVPNGISQDPHELFFFTERETYNTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDG8</accession>
    <name>W4TDG8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_19</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66990">
        <property type="protein sequence ID" value="GAE66990"/>
        <property type="gene ID" value="JCM18909_19"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="4">
        <location>
            <begin position="37"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE66990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20168" checksum="BF0ABC81B035D94B" modified="2014-03-19" version="1">MVGRINEEDIALVRERARIDEVVGEYVTLRHAGGDSLKGLCPFHDEKTPSFQVTPSRGLFYCFGCGEGGDTISFVQKIDNLTFVEAVQRLADKVGVQLRIIDDGRPGLEPGLRMQILAANEAAAEFFQSQMSTDEGRIAREFVAGRGFFPRCCRAVRDGLRTARWPRAARPPDGEGLCSQGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDJ3</accession>
    <name>W4TDJ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoxR-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_45</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67015">
        <property type="protein sequence ID" value="GAE67015"/>
        <property type="gene ID" value="JCM18909_45"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16574" checksum="D812FEB3A4FC2832" modified="2014-03-19" version="1">MLTPEAVVALQDMASDVFVHNLVAEYVVRLVLATRNPGDFGMSDLANVIQIGCSPRATLGLVAAARALALVHGRDYVLPSDVQAVAVDVMAHRLVLSFDAIADNVSASDVIERVVAMVPPPTPVWNEEQRQTAQHNYPNDRGQYPASTTPPAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDP3</accession>
    <name>W4TDP3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67070">
        <property type="protein sequence ID" value="GAE67070"/>
        <property type="gene ID" value="JCM18909_105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09022">
        <property type="entry name" value="Aldose_epim_Ec_YihR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037480">
        <property type="entry name" value="YihR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="299" mass="33046" checksum="C766313564F27695" modified="2014-03-19" version="1">MINDAILPTGTQYEISHGPWQAIVTEQGATLRSLRYEGEDVIKSFDADQSPTLSQGQQLLPWPNRIRNGHYTFDGMEQQLAVSEVDRHNAIHGLVAWSRWSLVEHTDTSVTQTIQIMAHPGWPGTINVRLTHRLSDAGLAVEVTARNVGTTAVPFGYAAHPYLCLGGTIDDWTVDAPFASWLQVDDRLLPVQMREMDSIHTLNGLTVGQRTFDTAYTVKGDGTVGSPAWRIRVSNDETSHELWGDAAMSWVQIYTPDDRHSLAVEPMTCGPDAFNEGPTHGDVIRLEPGNDVTLHWGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDU3</accession>
    <name>W4TDU3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alkaline phosphodiesterase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67130">
        <property type="protein sequence ID" value="GAE67130"/>
        <property type="gene ID" value="JCM18909_170"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="375" mass="40370" checksum="DE15ECF230B63D2A" modified="2014-03-19" version="1">MSSLLAADLMLPGPGTLSDLVPAMGQALTGGGPAGLGLPDATRYVFLLVDGMGQENLEQFRHLAPTLSEMENCHDLTCYVPSTTATSLSCIGTGAVPGRHGVVGYTFRAPSGRVMNALSWVNGDNPEVIQSHPTAFESLVAAGVTVSSVGPARFQRSGLTRASLRGPRFIPIRDEDDVDERVYKTLKASRSGDASLTYVYERSLDHVGHGEGWQSAAWRSRLMWVDELVGSLLDELDPGTALVITADHGMVDIPGDHRVMVEDEGGLLADVDLLAGEPRFRHIYTRRPDEVAQRWRRVLGDRAQVVIGDDAVAADLFGPVDVSTRSRFGDVLAITRGDWAIMSRATPKELTLVGMHGSLTPCEMRIPLLAQICEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDZ6</accession>
    <name>W4TDZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA primase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_20</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66991">
        <property type="protein sequence ID" value="GAE66991"/>
        <property type="gene ID" value="JCM18909_20"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="2">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE66991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="319" mass="35181" checksum="32A2B0EF4DB7CF03" modified="2014-03-19" version="1">MLDGSTTMTVCPPSTSIPPKLRSTKKSHVLYGLDLARANIGKKSQAVIVEGYTDVMAAHLSGIDTAVAACGTAFGDDHARLIQRLMGNSGSLNGEVIFTFDGDAAGQKAALKVFRGDNQFSSQTYVAVEPTGLDPCDLLMQRGPEAVRELVARRIPLYRYVMENTVSQFDLDRADGRVAAIRAAAPLVTSIRDQSLVDGYLRELSQVVGTDVDLVRREVSHARRQHRSEPQLTIVPPPEPQQGSGIPWPDPADVSLSAERGFLKLALQHPDLFNEEWGQVEVEDLRHPAYQAVFELCWLCRVARTDGRRKLVRRPRIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEC9</accession>
    <name>W4TEC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trk system potassium uptake protein TrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67141">
        <property type="protein sequence ID" value="GAE67141"/>
        <property type="gene ID" value="JCM18909_181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="109"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21496" checksum="DB009F008A5F6A86" modified="2014-03-19" version="1">MCQSLTLTTTRFAAWDLILKGAQSKASDSTVLYSKKAGIREADGFAAVSSGDNSNVLSARVVREEFGIDNVVARIYDQGRAEVYERLGIPTVATVRWAADQVLRSLMPEGSEPAWRDPSGQVRLIRVNTHTDWVGMKISAIQDRIHTPLPFLLRFGQGMVPDGATLLQDGDVVYAAVEVERITEIEGLLAKPPVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEF5</accession>
    <name>W4TEF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activator of (R)-2-hydroxyglutaryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67350">
        <property type="protein sequence ID" value="GAE67350"/>
        <property type="gene ID" value="JCM18909_399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14486" checksum="BE98635B06CCE546" modified="2014-03-19" version="1">MAVLTEDSVAHLGADLLERPLRVRDQWMFHSRLYQAAAFVGSRPDLELVQLNSFGCGLDAITTDQVREILAARDRIYTTLKIDEVSNLGAARIRMRSLQAASKERASHNRKLVTHPLSDDRVPFTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEI1</accession>
    <name>W4TEI1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">JCM18909_431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67375">
        <property type="protein sequence ID" value="GAE67375"/>
        <property type="gene ID" value="JCM18909_431"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="323" mass="35041" checksum="E732859DC3AEBBB2" modified="2014-03-19" version="1">MAVTGACTNKRLYLAAPRGYCAGVDRAVVTVEKALEVYGAPVYVRKQIVHNRHVVETLEGRGAIFVDELDEVPEDALVVFSAHGVSPQVKKEATDRGLRTIDATCPLVTKVHHEAKRFASQDTQILLIGHAGHEEVEGTTGEAPENITLVQTPADVDGLTLDRDRPVAWLSQTTLSVDETVETVDRIRDLHPQLIDPPSDDICYATQNRQHAVKQMAPKCDLVIVVGSKNSSNTGRLVEVALESGAKASYRVDNAGEIEETWLDGVSTIGVTSGASVPEALVQGVIDLLISKGWPQAEEETLIEESLSFALPPQLRKRRTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEQ0</accession>
    <name>W4TEQ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67271">
        <property type="protein sequence ID" value="GAE67271"/>
        <property type="gene ID" value="JCM18909_317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11862" checksum="3DB3FA2ADB9152E7" modified="2014-03-19" version="1">MIQPVDGMVVGGQYWLTVGVVRRLWDVRLVRVGRQLIALERMHVGFDVLGTSRDVGALGFDQSKLARVGSWIDDQVKAGFSGTSVLVCVMADCLASPCRSGPQVLHRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEU4</accession>
    <name>W4TEU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67475">
        <property type="protein sequence ID" value="GAE67475"/>
        <property type="gene ID" value="JCM18909_537"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="315" mass="34971" checksum="8BEE677AEA094211" modified="2014-03-19" version="1">MFGDGRLRTMAKTRPKVLSIVLAGGEGKRLMPLTMDRAKPAVPFGGTYRLIDFVLSNLANSGLTQIAVLTQYKSHSLDRHISITWRMSTMLGSYVTPVPAQQRLGPRWYQGSADAIYQSLNLINDQSPDYVVVFGADNIYRMDVDAMLQYHIDSGLGCTVAGIRVPRKDASAFGIIDADQNHKITEFLEKNRLIRLVCRTLRTSLSPRWVTTSSAARPWSRPSTTTLTVPTRGTTWVATSFRDSSTPLTRRCMTSVTTRFLATLRRMPTTGGTWAPSMLTTTRTWIWSQSSRSSTCTTRTGPSGLCRNRPPVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEV9</accession>
    <name>W4TEV9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67490">
        <property type="protein sequence ID" value="GAE67490"/>
        <property type="gene ID" value="JCM18909_552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7343" checksum="AF0AD5A1B09CF2A8" modified="2014-03-19" version="1">MTETRSTELSEQLRQAEKQKIPKRQTPFSKAFVEFIPTDWAPIPTSCPNRSARYLRLPHTVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF16</accession>
    <name>W4TF16_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_38</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67008">
        <property type="protein sequence ID" value="GAE67008"/>
        <property type="gene ID" value="JCM18909_38"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="424" mass="44495" checksum="E6B95E5126A6F774" modified="2014-03-19" version="1">MVYGLLFFVPMAPVAVFGLVVNRSGGVPVLVYLVAAAVMGLSAISYREMALRFPVAGSVYGYTRFSLGRTPGFIAGWLILLDYILMPALLTVLSAVALATFGPASPWGFSPLFFVLASMALNLQGVTVTTRVGIVLLTIQLATIAFFLVCVGLGLAGGGVVWSWHALWRSGTSWTSVASAVSIAALSYLGFDAVATLNEEARGGGRAVGIATLSLVGLLAVLFGIQVMAAGLVSDATHFAPGGATDRAFYHAVDTVCPAWFIPVFTVVNAFVAIFACLVVAHSSTARLIFAMARDKVMPPVLSRTNSKGVPWVAIAVVATVTAILAITFDSHVETMTTLVTFGALSSYVLLHADVIVQCIVKEKSHNWVRHLIVPILGALTLLVALAKTEEMTRIVGLSWLAAGIVGAVIARVRHSHHVGTGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF46</accession>
    <name>W4TF46_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67585">
        <property type="protein sequence ID" value="GAE67585"/>
        <property type="gene ID" value="JCM18909_657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="9897" checksum="501498E4D828F744" modified="2014-03-19" version="1">MKGLDMSTATPVVSCSVTDCAFNDFGCTAFAVTVGGASGQPTCATVTHLDARAGLSSADSRVGACQRIECVHNDKLMCTAQQVAISDAASCTAYQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF91</accession>
    <name>W4TF91_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67098">
        <property type="protein sequence ID" value="GAE67098"/>
        <property type="gene ID" value="JCM18909_134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="264" mass="28796" checksum="7AD8A7A29AD8D9A5" modified="2014-03-19" version="1">MDEPPDFAFDLDRSTAQAWDQFAERLAEVVSVIDDDGELTISTLSARTDTAPFIRFVQDDPGCSDDTAMILAEASSNNCLPESACLTPGQLDSLSSLGWQDPGTCKVHQTDNYWVYRSQDDSEQLAELTVTTLRDIFGVPHPVFLAPDQLAEILQPEPPLSPTEAASVPAIMPVDKGHLDRLVADELSHMFGHPAIRDSEGDFAIRVGTCMVFVRTTPDASELLLFLLLSSMTLKGVLVPLRYSMTSMCNPATGVSPFIKIECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF96</accession>
    <name>W4TF96_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67103">
        <property type="protein sequence ID" value="GAE67103"/>
        <property type="gene ID" value="JCM18909_140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024590">
        <property type="entry name" value="HrpA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11898">
        <property type="entry name" value="DUF3418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3418" evidence="1">
        <location>
            <begin position="2"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24932" checksum="C0CC3E0399CD5D30" modified="2014-03-19" version="1">MKLLILNLPDPTKWVVTHMDNATKLALATSPYPSVPALLADARHKAVASVAQEKVGDLSGIRDKKTFDDLALVVRQDQADRMARVARTAGRILSRVVAARQALATVSDPAIHADIVAQIDDLVFENFISATPDPWYDDMPRWIQGVSVRIESLMTNPSRDPRQMAELEPLLADYDALCEEQPAGKLPAEVEEIGFMLEELRVQYFAQKNSVLVSVCHPSEFVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFA2</accession>
    <name>W4TFA2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67436">
        <property type="protein sequence ID" value="GAE67436"/>
        <property type="gene ID" value="JCM18909_497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="19699" checksum="279A7350CF7EAE37" modified="2014-03-19" version="1">MSQTWLIVIDPQTIFASPTSPWGSPAFPTIIDPIDRMVAAFHGRTIVTRWIPTATRCGSWCDYFDRWTFADRPANDPIFDLADEAQPWAERPTIDVATFGKWGSQLSAVTGEHPHLLLAGVSTDCCVITTALAAADAGAWVKVVSDACAGSAPDNHEAALTVMDLYSPQIDVVTSSHVLATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFB2</accession>
    <name>W4TFB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase GroES-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67446">
        <property type="protein sequence ID" value="GAE67446"/>
        <property type="gene ID" value="JCM18909_507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="3"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="186" mass="19137" checksum="AD7C4CEB899F2E39" modified="2014-03-19" version="1">MLAVEATTICGTDLRIISGEKTTGVRPGVTLGHEIAGRIASLGEGVEGLVVGQQATISIVVSCGTCRVCLAGREHLCSHCELVGYGLDGGLAPWLCVPARAVSRGNIIPVATEIPATRLALAEPLSCVLNGHRRHGGVNPGETVVIIGGGAIGLLHTALNLACGAGQVILCEKHADRRDRAAAWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFD9</accession>
    <name>W4TFD9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methylisocitrate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(2R,3S)-2-methylisocitrate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Probable 2-methyl-cis-aconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.99" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67148">
        <property type="protein sequence ID" value="GAE67148"/>
        <property type="gene ID" value="JCM18909_189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="11">
        <location>
            <begin position="64"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE67148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="709" mass="76815" checksum="192BB416542C4EAF" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFE2</accession>
    <name>W4TFE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endoglycoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_543</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67481">
        <property type="protein sequence ID" value="GAE67481"/>
        <property type="gene ID" value="JCM18909_543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901136">
        <property type="term" value="P:carbohydrate derivative catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="4">
        <location>
            <begin position="68"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_5_C" evidence="5">
        <location>
            <begin position="284"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="374" mass="40420" checksum="C5BEB2B0F3A4374D" modified="2014-03-19" version="1">MTLLDAHQDMYNEKFEGEGAPDWAVLDKGAPNLLKVSFPANQVFNLGLIKAYDSFLDNAKGPGGVGLQDRYAAMWKHVAQVVGQEPGVMGYDIINEPWPGHHYPICYVAFGWCGRAMVSLDTLYEKVGRAITSVDPDGIVTYEPYSTWNMGLDSRPARPSSPKAAISWHVYCPMNAIFGSYVGCNLPDTRTFHNADQAAQFNNSASLLSEFGATKDPGTLMGVTSKARAHLVGWLYWTYNGNSDPTTQNAADEELVRHINRPGPVTDEQVDHTKLAILAVPHLRAAAGTPTSTTWDQSTRTYQATWTAKRVTGDGDFAPGSVSEIAVPAVHYPNGYKVEVKGAKVISKAGDTRLQVSSTGEGPVSVTITPAGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFJ9</accession>
    <name>W4TFJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67546">
        <property type="protein sequence ID" value="GAE67546"/>
        <property type="gene ID" value="JCM18909_613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6054" checksum="A2F5A0F9BE4F6ADB" modified="2014-03-19" version="1">MVWWFPAGHNRELAATWWQKILTDAYELVGVATLVVLARNRRRCESGVSAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFQ0</accession>
    <name>W4TFQ0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">oligo_HPY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67800">
        <property type="protein sequence ID" value="GAE67800"/>
        <property type="gene ID" value="JCM18909_885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="oligo_HPY" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="401" mass="42057" checksum="F24F99876991D2DC" modified="2014-03-19" version="1">MEIGEANKVVDHPRHPYTRALIEAIPVADPAHHVEEIVRLQGEPASAIDTPPGCRFKKSVPICHQQVCRRTPVSGRHTPSGLPLPTPARRLGSIMSHPGTYRPVVAIDIGGTTMTIAEVRSDGSVRDPVTMDSPARIHGDEVVARICELVETRWPHPCRIGVGTAGVVDPISGSIGRASDSFQGWTGYPLRERLEEALGVTVQVENDVNAFLVGEQRFGAAAGERDCLGIMLGTGVGGAVILDGQVIHGRRGAAAEIGHMPALGNDRCSCGVPGHLESLAGGRAIARRWAAATGRDPTSVNGAREVARRAANGDAVAPRILAEAGKALGIALVQAATLFDLSTVIVGGSVARAWQWLSPGLHDVVTAYPLISGAELRVRFASLSDRAVLIGAANLGACDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY0</accession>
    <name>W4TFY0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67343">
        <property type="protein sequence ID" value="GAE67343"/>
        <property type="gene ID" value="JCM18909_391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021229">
        <property type="entry name" value="DUF2800"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10926">
        <property type="entry name" value="DUF2800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23188" checksum="1A56507A9855A389" modified="2014-03-19" version="1">MGVLVEAERNPQLMLYAFGALHTFGDFYDIETVAVTIYQPRRANVDTWEISVAELQHWAETEVKPKAELAAGEGRFCPGSWCQFCKIAATCRARAKANLALARLEFAPPAELSDVEIADVLAKIPDLKSWASDVEAYALSKAVNQSVVFLRVSSSSLGVRCANTSPKQTWLRRPKLLVIRTFMIASSSRSRQWSVSWASRLSMRSSVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ2</accession>
    <name>W4TFZ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67890">
        <property type="protein sequence ID" value="GAE67890"/>
        <property type="gene ID" value="JCM18909_982"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4401" checksum="E8BBC25E8F4327F4" modified="2014-03-19" version="1">MPKLIVVARVIVIGLSTMWALIICGLWVAGRSESQSTSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFZ3</accession>
    <name>W4TFZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67706">
        <property type="protein sequence ID" value="GAE67706"/>
        <property type="gene ID" value="JCM18909_785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="18083" checksum="3FBEC1EF8DD0DE31" modified="2014-03-19" version="1">MASFHRDGVEPLGLLTWFVIVAHRTGRWNGYLLVQKAWGSEMGTLLDTWEDLHSRMDHVPFDWRYTGLVALAWCMYLALGIVMAVRREQVWLTVYVLVTVIFVGHMQGYFNSKARFLLPAFPAFLPVARLLDRSPRWLQAVFVLVISQSRRGGAWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG32</accession>
    <name>W4TG32_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67393">
        <property type="protein sequence ID" value="GAE67393"/>
        <property type="gene ID" value="JCM18909_450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7964" checksum="5C06730A35CF91E8" modified="2014-03-19" version="1">MHFMNGNSTFSHLGHEISMIFLCFFSTHRTSSKSNSLQLLGVSRRCARRGSHTITSRSLPTSDHAPMGVVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG43</accession>
    <name>W4TG43_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67761">
        <property type="protein sequence ID" value="GAE67761"/>
        <property type="gene ID" value="JCM18909_843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6012" checksum="6A0533C218757935" modified="2014-03-19" version="1">MAVEDDVNIGGRVSVDRCEVAALAGGIPGTVGSASWYSATTTSARPSLLRRLARHSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG99</accession>
    <name>W4TG99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lactam utilization protein LamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67980">
        <property type="protein sequence ID" value="GAE67980"/>
        <property type="gene ID" value="JCM18909_1083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="10395" checksum="2F074CEC9B805C78" modified="2014-03-19" version="1">MTSLSSSVRTLSEAFADRAYNPDGTLVSRRQEGSVLHDPGEVAERVVTLVTQGSVTAIDGTEVPIKADSVCVHGDTPGAVAMATAVRDRLASAGVELRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE1</accession>
    <name>W4TGE1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67219">
        <property type="protein sequence ID" value="GAE67219"/>
        <property type="gene ID" value="JCM18909_264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="221" mass="25170" checksum="FF757E54904FEF84" modified="2014-03-19" version="1">MTRTGTDPMDRWRFPDDPWAIVETAPSTDDLGTTETLFSIGNGYLGMRGNPSEGRDSFSHGTYINGFHEIWDIHHAENAYGFARTGQTIVNVPDAKLMKLYVDDEPLLLSINEIQSYKRWIDFREGVLRRELVWRTPAGKLLRVATSRMVSFTHRHMALISIEVTMLEGDARSSLARKSLTVRTAWTSTMLDLTTPRRLLTLAKLVNLPTRCSFLKKRLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGE7</accession>
    <name>W4TGE7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA repair protein RadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S16.A04"/>
    <dbReference type="EnsemblBacteria" id="GAE68030">
        <property type="protein sequence ID" value="GAE68030"/>
        <property type="gene ID" value="JCM18909_1136"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="240" mass="25739" checksum="08F38FBA553888F5" modified="2014-03-19" version="1">MEHLVDVVLNFEGDRHSGFRMVRATKNRYGPADEVGCFEMTDAGIMEVPDPSGLFTSDNADPQPGTCVTVTMEGRRPLLSEVQALVAPSASEKYPRRTTHGVEGGRVAMILAVLERKAGLPLSNRDVYVSTVGGARVSDPSADLAIAVAVASAVLDTNFPTRIVALGEVGLAGDLRRVPGLERRVGEAARLGFDLAVVPRNSREAHTKIPTMHGLHVIEVGSVAEALSVLNLRRQRKINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF6</accession>
    <name>W4TGF6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin-antitoxin system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67493">
        <property type="protein sequence ID" value="GAE67493"/>
        <property type="gene ID" value="JCM18909_555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13307" checksum="6CB13AE03AE4CBB0" modified="2014-03-19" version="1">MNSLIVTATRWSGGWELEIGEQQHTQVRNLCNARQQVVDYLDTMDESVDHADVDITIIPEIGALADEVAQAREATRAAAEATEMAARQSRAAAQHLRAAGYSVSDSAVIMGVSRGRVSQLVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF8</accession>
    <name>W4TGF8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-uridine 2-sulfurtransferase</fullName>
            <ecNumber evidence="2">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67239">
        <property type="protein sequence ID" value="GAE67239"/>
        <property type="gene ID" value="JCM18909_284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="320" mass="34608" checksum="F2D0AAF9CBD19088" modified="2014-03-19" version="1">MKVLAAMSGGVDSAVAAAVSSRLGTTSLGFTWPCHATRALIVRDREGAARWKIPSTRGALRTDWESPFMYGIFSDRFVAEVIDPFIAEYRAGRTPNPCLRCNERIKFAALLERGLDLGYDAVATGHYARTKVIDGVTKLYRSVDPGKDQSYVLAVLNQDQLSHSLFPLGNSLKVNVRQEAAALGLSVADKPDSNDICFIPDGDTPGWLSEKIGSADGEIRDESGALVGRHNGYHHFTIGQRRGLRLGVPAPDGKPRYVLDIEPVNNTVVVGGAEGLTVRHIEPSGRCGVLASLSRPGTVRPRSVPMETRCQPQFPQFPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGJ4</accession>
    <name>W4TGJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67274">
        <property type="protein sequence ID" value="GAE67274"/>
        <property type="gene ID" value="JCM18909_320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="149" mass="15876" checksum="ED64A19A11F6B7B6" modified="2014-03-19" version="1">MAGTGFMKGWGIIGIIIGVILIIHPGFSLHVIAIFMGVWLVLLGVFATSFALPLRLVTQKAWGWMFGGGISLFVLGIVILVHPGFGVVAMSWLLALGVLLYGVANLAIAVGIRKITSSISLAMRRNPHNTIIEGDVVDSPDTSTRPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGL6</accession>
    <name>W4TGL6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67563">
        <property type="protein sequence ID" value="GAE67563"/>
        <property type="gene ID" value="JCM18909_633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_dom4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BetaGal_dom4_5" evidence="8">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20b" evidence="7">
        <location>
            <begin position="149"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="289"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="437" mass="46300" checksum="6E0EA45DDAE8045E" modified="2014-03-19" version="1">MPDKDWTAATTMTVDHPGIRWYRSTFDLSVPTGQDTTFQVVVKPSGNGKGPGGVGADHSQATIFVNGWNTGVYVGDVGPQTRFVIPAGFINPHGSNTIAVAVAAKEAGSGPASITVEPTHSVTGSLVGALNKAPAYSPRTPDPATGTVPSLVPLPASLRTDSGAPFALKDSTVIVAKGQASESTTFLATILRRSTGFPLPIVSSGSSHNSVISLTVDPHTRIGTYARQEEAYSLVSRAGSITARAVTSHGLFDAVQTIRQLFPPLIESARPMMRSWTAPAVTITDAPRFSYRSVQLDPARSFLTVDEVRSVLDVMAAHKMSVLHMHLADDQAGGSRSPIRAAHPATLSTTRNSPRCPDTPQWTPRSTATAMSWVAPVLHSAAVPQHRLLCRCSPHHGGPRDRLAGPLQRDVARLPRTQQCQLASGNHGLRDGAAERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGR6</accession>
    <name>W4TGR6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67618">
        <property type="protein sequence ID" value="GAE67618"/>
        <property type="gene ID" value="JCM18909_691"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011089">
        <property type="entry name" value="DUF1524"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07510">
        <property type="entry name" value="DUF1524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1524" evidence="1">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11556" checksum="93D95503A0AA4B5F" modified="2014-03-19" version="1">MVQIDHVVALGNAWVTGAQQLPMDRRQALANDPLNLLAVEGQANQNKGAGDAATWLPPHKSYRCDYVSRQIAVKRKYHLWVTSAERNAMIRVLSTCPNHALPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH05</accession>
    <name>W4TH05_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67713">
        <property type="protein sequence ID" value="GAE67713"/>
        <property type="gene ID" value="JCM18909_792"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="4818" checksum="81C3FDC080DC8639" modified="2014-03-19" version="1">MMYRGRIVGIAPAGTPRDVLGLMMAGFSYDEACDSVAKGHKEVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH14</accession>
    <name>W4TH14_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67723">
        <property type="protein sequence ID" value="GAE67723"/>
        <property type="gene ID" value="JCM18909_802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="42"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="210" mass="23142" checksum="A2B17157F12097E5" modified="2014-03-19" version="1">MALQKWPNRGASNATPAGFMSTRRTQRRSFFVPSPSQIAEPSFVAVDFETANRMGGVSACQVAMVKVCDGQIVDRLNTLIRPPKGWDSFEFTYLHGISAADVADAPGWINIADTVSHFVDGATVYAHNAAFDSRVWRQLDEHFGTTTLPAPFFCSYRTAQRLIPGLPNYKLPTVLHACAPNYQLNHHRADSDAEACALIVCELQRRAQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH18</accession>
    <name>W4TH18_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67414">
        <property type="protein sequence ID" value="GAE67414"/>
        <property type="gene ID" value="JCM18909_473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="4">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27197" checksum="23D25B80162D0640" modified="2014-03-19" version="1">MWNRVGEVFEVPAAKRGARQEAVTSWRELTRDDPYVNILRGTIATFGAAVGGAEAVTTLPFDAAIGLPKSDFSRRIARNTGIILAEESNIGRANDPAGGSFYVEALTKKLEDAGWAEFQAVEAAGGMAAALTGDHVRTELDKLNTERAKRLATRKQPITAVSEFPLLDAKSVETKPYPAAPAREGLEWHRDAEVFEALVDRSATCLSVQKCSWPAWEPAVTLARARDSPPRYGTSPAWKPPSARGAPPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH37</accession>
    <name>W4TH37_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67434">
        <property type="protein sequence ID" value="GAE67434"/>
        <property type="gene ID" value="JCM18909_495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="116"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="148"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE67434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="377" mass="41263" checksum="BB13D0A81226D12A" modified="2014-03-19" version="1">MKIKNITPDEFVEQSETEAGPSTKVVHETTDLLTQKKASILLVNGQTSDDVTKALQKAASKANVHEVGVWETFPEASTTTQTSLARPSIPSTRLSLTLVTSHRSDTTGTTMRIEPARLTDAKVAFGNRVLWSGLDLIVEPGEFIAVLGPNGVGKTTLLRVLLGQIPLTAGTAMVAGRPVRRGSTHIGYVPQQRSLETTAPIRGRDLVGMGIDGHKWGFGWFSRSRRRRIDEAIASVGATAFANAPLTMMSGGEQQRLRIAQALVTNPQLLLCDEPLSSLDLRHQQEVTRLIDDARRTRNLGVLFVTHEINPVLPYVDRVVYIAGGKVRVGTPDEVLRSDVLSEMYGSHVEVFHRGNRIIVLADEERSTHLHAPGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC9</accession>
    <name>W4THC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67554">
        <property type="protein sequence ID" value="GAE67554"/>
        <property type="gene ID" value="JCM18909_621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="190"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="449" mass="49415" checksum="97FB627E7D5B0D76" modified="2014-03-19" version="1">MRDYSNKYGYAPASSSVIDGAIIEDSVRHRLMIVIDLWAWNGGVFEHLNVSADGSVNGGRPRNFPLGDGFATVAGRDMLLLSTHNVTGDADGLRGNINLNIDRSQFDLVADLDGPRNKHGRIRIYELIGIPRPYTTTGVDDSNLTLGRQSRYSLDDDFNLFEAGIPLYVFQHGSARITPMRVFYKDSILQVFNTNHIVEIYSYDDDRTWNMGKLVTRQFRPVDSRYTLVAPGRSIQIRAGEHAGRIVVPTYMMLPAGVSCTTVYTDDGGETWQRGIPMPATIDLHESAIIEVLPGVLRSFNRHSASSGGKVLTAESVDGGHSWSTLTSAFGDDDQGVACQVSALMLKQTIASPTTGEQLPALIVVSADDRRRRHGIAHVVVIHRSSRTSGPRSELEWVSHTDITSPQTLFAYSSIAQLSDGRVLVLFESSPTDSWADGLQRMYLQELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THD2</accession>
    <name>W4THD2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68370">
        <property type="protein sequence ID" value="GAE68370"/>
        <property type="gene ID" value="JCM18909_1499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="45" mass="4675" checksum="0DED825320B87000" modified="2014-03-19" version="1">MSIEDLDSTNGVTVNGVKVTSTELGDGSRIEIGSTRMLVHSPTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE6</accession>
    <name>W4THE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane component CbrV of energizing module of predicted cobalamin ECF transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67579">
        <property type="protein sequence ID" value="GAE67579"/>
        <property type="gene ID" value="JCM18909_650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="372"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="541" mass="58356" checksum="B7FAE0846D5D31EC" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THE8</accession>
    <name>W4THE8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exported protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67917">
        <property type="protein sequence ID" value="GAE67917"/>
        <property type="gene ID" value="JCM18909_1015"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850753" evidence="2">
        <location>
            <begin position="28"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="162"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="356" mass="38295" checksum="7E3C1587D1A009DE" modified="2014-03-19" version="1">MTPRVSRRRMFVAALMASSLFAVTACASAGSRPPQSASASRQSAPHKLSASPSVTASVVPAQDKADANPPVASFDPKAHVLMEGPQSPDRQVMHPARDNKPFSKAPAGRGINRYLSRKISWHDCGTFQCADIPVPLDWDDPDGPAITLALKRKPAEGAAKVTLFINPGGPGGSGQEMVSSFQSSAFPDHDVIGWDLRGTGASTHVNCGPVKTMDGLFSLDASPDNEAEWNGLIRGTRDFARSCRAYSGQLLDHVSTIDTARDLDYLRYLVGNKKLDYLGVSYGTFLGATYAELYPGRVGHMVLDSTVNITNHDTVSQAVGFDRAFGDFAQWCANRENRCALGTSEAEIRKATLNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM7</accession>
    <name>W4THM7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68440">
        <property type="protein sequence ID" value="GAE68440"/>
        <property type="gene ID" value="JCM18909_1578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="20278" checksum="208516DBB89743F4" modified="2014-03-19" version="1">MRCPWYMTTTSSPIPLNSALVDHSGIFLELDRDWWPDELCIVSSAPTLSRNEDDSQARYEAVRLTRAAHIIIVETMAGRRPMSQLVKASNTRAVATMRRWPRGPGWSRMLLVGEPHVSYDDNRVDGVGLLDLRGRRLPLATSQILEERTWRLDAVELVLNPKVATLLTLKKITCETVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THW2</accession>
    <name>W4THW2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-N-arabinofuranosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68530">
        <property type="protein sequence ID" value="GAE68530"/>
        <property type="gene ID" value="JCM18909_1675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="44" mass="4663" checksum="DA21CCE210557C01" modified="2014-03-19" version="1">MATCGSSDRSMPIFGRRERVVADAAFDSLDLVSATPTTNRSTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI01</accession>
    <name>W4TI01_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aminopeptidase YpdF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68152">
        <property type="protein sequence ID" value="GAE68152"/>
        <property type="gene ID" value="JCM18909_1271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12533" checksum="11DC4EAA6F047F02" modified="2014-03-19" version="1">MLLRTVFSEEAPAQLVEAGIDCIEHGTGLTDETIATMAERGVGLVPTLINIETFPSIAAQPTASSQNMPHICVTSMLTVMKRSPRLGMSECRFMPVPTLAALSSTASLPLRFGCWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI52</accession>
    <name>W4TI52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68212">
        <property type="protein sequence ID" value="GAE68212"/>
        <property type="gene ID" value="JCM18909_1334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="166" mass="17809" checksum="DE902AADC6B8D931" modified="2014-03-19" version="1">MWRAQTEGLPQTSTPQDHGPQDACGVIGIYAPGEEVSKLTYFGMYALQHRGQESAGMAVSDGRHMMVFKDMGLVSQVFDEATLNSLQGHMAVGHTRYSTTGASIWDNAQPTFRSRQGGDGLALAHNGNLTNTGALEALIAERAPDTEVPHKDRMDSSNDTSLVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU2</accession>
    <name>W4TIU2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Agmatine/putrescine antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68343">
        <property type="protein sequence ID" value="GAE68343"/>
        <property type="gene ID" value="JCM18909_1472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="265" mass="28448" checksum="9EC80C46F5DF954B" modified="2014-03-19" version="1">MAKDQTKVLQRTLNRFDIVFLIVSAVVGLEMLGSVSAEGPETFTWLVFLIIVFLIPYSLIFAETGSAFVGEGGVYLWTRRAFGRPAAAVTSVFTWITQPVWVGGSMAFLNAEAARNHLVHFSAGSAGDYLFKLAFIWLTVFAAILSLAKAKWIPAAGAFFKISFLCLFLVTAAVYATQHGVQPLSLGSFSPTLRGFITLTPLLLFAFLGFEGGSSASGEMRNAQHDVSVSVLRSATMAGIFLPPSSGNDSARPASLRHRRGIGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIU4</accession>
    <name>W4TIU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal subunit interface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68437">
        <property type="protein sequence ID" value="GAE68437"/>
        <property type="gene ID" value="JCM18909_1575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="2">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="23789" checksum="2C214E6CAB8164EB" modified="2014-03-19" version="1">MQTPAQEVVMEVIVSGRHCHVSDDVRVQVEDRLSGVEKLKDRVQRAEVVFTAQGTKGPKDQAMTCEITLRAKGPVVRAVGQAEDKMVAFDMAADRLRTQLVKAADRRRSRRGLRVSQVLDVLPEESTDDAPDILTTRTIAGDVEVTGDSPIYVKEKIFQAVPLTLAQALDEMELVGHDFFLYLDQDSKRPSVVYRRKKGYNYGVIHLDLDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV2</accession>
    <name>W4TIV2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68447">
        <property type="protein sequence ID" value="GAE68447"/>
        <property type="gene ID" value="JCM18909_1585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8639" checksum="2CD12934635CD953" modified="2014-03-19" version="1">MEESGHLDRAVDTMPSTTEMNRRMAAGERLASPELCTLLAWTKIALCDAVLATDLPEDPFVADRLVGYFPPLFEGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ1</accession>
    <name>W4TIZ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68124">
        <property type="protein sequence ID" value="GAE68124"/>
        <property type="gene ID" value="JCM18909_1241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7734" checksum="93A1A9CD4833C4FF" modified="2014-03-19" version="1">MHDHAPILDDRVHRHLAEKIRPAETTTVCHLNVEWAPVTDTVEGLNSRPGVVGQGEPISISAGLALAYEPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ14</accession>
    <name>W4TJ14_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68527">
        <property type="protein sequence ID" value="GAE68527"/>
        <property type="gene ID" value="JCM18909_1672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="50"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="302" mass="32178" checksum="499B6AFD5B2E05C1" modified="2014-03-19" version="1">MYYMQGETMDTIASHLGTSRSTVSRLLKQARLSGVVRITLSEPTGLRSGLDSTLTRMFGVNTTVVPVKSGTTEIHRLDQVARIAGQMVTDMVEDNSAVGIAWGTTLDAVTHYVVPKDVKGVSVVQMNGSANPASSGIPYVGSILSRMAAAFGGEVIHFPVPTFFDSASTKAAMWQERSVQAVLKAHRELDLAVFSVGALDSPVPSHVYSAGYMTDEEKANLVHAGVVGDVNTVFLKADGAYDVEFNKRATGLAPFQLQRIPRRLCVVAGRAKAVGLLAALRARVATDLVVDDATARAVLDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ40</accession>
    <name>W4TJ40_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation ATPases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68960">
        <property type="protein sequence ID" value="GAE68960"/>
        <property type="gene ID" value="JCM18909_2137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025111">
        <property type="entry name" value="DUF4032"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13224">
        <property type="entry name" value="DUF4032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4032" evidence="1">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="472" mass="53821" checksum="98BC7B8C7EB49DCA" modified="2014-03-19" version="1">MGGKLFLVTRFLSAKPDSRLLPLPWSTPLAQWPQERLVALPRGISRHVVRFITVDDDVYAAKEVVEHLAIHEYRLLHDLMRLDTPSVEPIGVITDRVASNGEPLEPIILTRHLRFSLPYRSLFHSGVRQGTVMRLLDALVVLLVRLHLVGFLWGDISLSNVLFRRDAEAFAAYLVDAETGELHNHLTTGQREHDLQIARTNLYGEFLDLEEGDMLDDALDPLGLVTTIEDRYHDLWNELTAAEEFDGGDYSQVESRVRRLNALGFDVAELDIQTSPDGQRLRIQPKVVDAGHHQRRLLRLTGLDTEEFQARRLLNDLDTFRARNGLQGVDEAVAAHRWLTECFEPVVQQIPPELSRKRELAQFYHEVLDYRWYKSQRQQREVPHVEAAQGYVRDILAKLPDEAISTESVVPVDGSPAHSGHELVNVYDPSLGYVEDEEEDAPYDPWEAHAEAIDVESASRLDIDALRARMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ50</accession>
    <name>W4TJ50_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68189">
        <property type="protein sequence ID" value="GAE68189"/>
        <property type="gene ID" value="JCM18909_1311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="132" mass="14510" checksum="6F6D2430487058FB" modified="2014-03-19" version="1">MLFCFSLAGCSTIQAETDEDAAACADYAVPDALRKELDLRGLTSPTARADAAQTWFNETRPVDISIGGYWVVRWRRGTRFRVDLYRHMKSGSLLPPDAGKSASSVACRVYDVAHGVTVQQVDCPKESLDQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ79</accession>
    <name>W4TJ79_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">JCM18909_1744</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68597">
        <property type="protein sequence ID" value="GAE68597"/>
        <property type="gene ID" value="JCM18909_1744"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UvrA_inter" evidence="14">
        <location>
            <begin position="131"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="UvrA_DNA-bind" evidence="13">
        <location>
            <begin position="295"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GAE68597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="570" mass="63480" checksum="73EBC743B10CE996" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ94</accession>
    <name>W4TJ94_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sugar transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68229">
        <property type="protein sequence ID" value="GAE68229"/>
        <property type="gene ID" value="JCM18909_1352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5455" checksum="669FA0CD785BFBF5" modified="2014-03-19" version="1">MTSDHSDGQPGTYQHSHLRGLFLSVLPLVALFLLLQRYWKTGLTTGGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJA6</accession>
    <name>W4TJA6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68622">
        <property type="protein sequence ID" value="GAE68622"/>
        <property type="gene ID" value="JCM18909_1769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19116" checksum="5A9BF6A7DE1DF371" modified="2014-03-19" version="1">MTVTDVEGNKVTIKSTSRILALDLYGTLSRTLIGLGLGDKIVGRTVSSTEKQLHDRPVVTENGHVLNVEAVAGLKPSVIIADRSVGPKEALDQLRKSGIPVVLVDPHRSVGSTPQLIRTIANAVGKPDAGEALVKRTQEQINQAKKADSSMETCQADASRFPLRSRKCWHFLHSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC1</accession>
    <name>W4TJC1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68637">
        <property type="protein sequence ID" value="GAE68637"/>
        <property type="gene ID" value="JCM18909_1787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="4838" checksum="184555021EDC5A2E" modified="2014-03-19" version="1">MPIMSAAPLQPSFDDLGTSLSEVTFCVVDLEATGTSEAPRSPRSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM8</accession>
    <name>W4TJM8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Preprotein translocase secY subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69160">
        <property type="protein sequence ID" value="GAE69160"/>
        <property type="gene ID" value="JCM18909_2350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19632" checksum="BA0E85CDB9678E5F" modified="2014-03-19" version="1">MLSAFANAFRTPDLRRKILFTLFILAVFRLGSVIPVPNVNVTNINTCVTQASSGSSAGLYSMISLFSGGALLKLAIFALGIMPYITASIILQLLTVVIPKLETLKKRRRVRSEQDHPVHPLPHSRAWPVAGNGLRHACHLRPSIHLQLASRLLHLGLRSRCHDPDHDGRYDHRHVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJR4</accession>
    <name>W4TJR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Homolog of fucose/glucose/galactose permeases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69195">
        <property type="protein sequence ID" value="GAE69195"/>
        <property type="gene ID" value="JCM18909_2387"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="273" mass="29830" checksum="32DC7570C5DC1E58" modified="2014-03-19" version="1">MGKFLVFTDGAALHERVAHAHTVAEREVITAEALGRTLDPYRIIIMMLVVLVVLITITQYPHSKPLRNDAEEAKAPIGETLAYLAKNRLFRAGIFYTVPLCGLTDVIMDIHHPAGLNLDPALNERTAANYLIAAFISFFLGKTIANLLMTRMSENGILMAYSLLGVLCITYIVVVPSFTTVYAAVIASALLGPGWATIFARNLDLIEDKRYTETGGAIIVMSIIGGAAIPVVQGFLSDTTGSMRFSFIVNAFCFTAIFVFFLSRRSSRSETNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT0</accession>
    <name>W4TJT0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69210">
        <property type="protein sequence ID" value="GAE69210"/>
        <property type="gene ID" value="JCM18909_2404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="19924" checksum="4A39C87D8BCD7056" modified="2014-03-19" version="1">MVIEVPEDFSTNIVSAGDFRPARATLQLHRDDANGFIIGLLTSQVQTALEQALDQSVSETYFNALFVNLGVIKQSLTKASDGSAQIDNGLKTLDAGVTEMNNKVLGATKAVGDSTTTVNQVNSALANADSAATKASSAVTQTRVGAQAITGAAQNVMADSQAVNSSMIPLINNVTKNLPALQKNRPGISYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV5</accession>
    <name>W4TJV5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68713">
        <property type="protein sequence ID" value="GAE68713"/>
        <property type="gene ID" value="JCM18909_1865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19075" checksum="83AEFA16989D5134" modified="2014-03-19" version="1">MLKTLGDKAAVAASQVMNNKQCDAAIVYDLAKASPIRLGEMAGVGPLNLDKSTSELASTIHVIPDGVGDGCTRNPTAYSRYGDLLGGVWTQGGKAQAYLFTGGNNATSNGARIGITEAQLRSDYSKLKLTDDSTEFSGMKLGFQKALAYSYHGKEIDYLIDGGKVVAYMIRNSDFSPTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX6</accession>
    <name>W4TJX6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68414">
        <property type="protein sequence ID" value="GAE68414"/>
        <property type="gene ID" value="JCM18909_1549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10915" checksum="20666A1B1EF151C6" modified="2014-03-19" version="1">MTHKIAYRQPFGPSAVDVTFIAPEDPDALASELDRGDVSGVFMEPIQGEAGVIPLSDEYLQQVRELTACHDVLMVVDEVQCGMGRTGRWFAHQALTSPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK49</accession>
    <name>W4TK49_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68504">
        <property type="protein sequence ID" value="GAE68504"/>
        <property type="gene ID" value="JCM18909_1647"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5644" checksum="529CC9F13837A2F0" modified="2014-03-19" version="1">MVQEAPNPTSTDSFDLSLTQSAAIAMVAERCGKIRTVTILHRRRHVLIHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK75</accession>
    <name>W4TK75_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sugar-bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68544">
        <property type="protein sequence ID" value="GAE68544"/>
        <property type="gene ID" value="JCM18909_1690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="61"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="302" mass="33285" checksum="353707FF3B9E51B2" modified="2014-03-19" version="1">MSNRRRAHQDEKMLHVAEMYYFEQMTHAAIAQRLSISRWTVGRILEEARRTGMVKITIDHPLARHHRLETELVDTFGLQSAVVVPVQANDELTMEFVTRMAAQRLSEWRPRPRVVAVSWGRTTAHVARHLGSGWNPDVVIAQTNGGVAVTRNDLVGRSVVRMAELGPGQSLTLQAPTVVESADLGEMLRQDVSVSRPLEAAQNADLVVYSPGAVSADSILVTAGHVTTNGIDQLRSKGASADIMSHYVDVHGRVVDEELDTRTISVDLDCVKVRDDGGHGRPWARSVLVVASGVEKKQRLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK92</accession>
    <name>W4TK92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68853">
        <property type="protein sequence ID" value="GAE68853"/>
        <property type="gene ID" value="JCM18909_2018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMS_C" evidence="2">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="219" mass="24519" checksum="C7ECB3BA4A6AA173" modified="2014-03-19" version="1">MASRIAKSISVEDTFEHDLTHREECRQIVERHAGLVCGRLKKSGQFARTVTLKAKMADFTVWSRSVTLTGATDSLERISQLAVRMLDSLDLREGVRLLGVGVSNFATSAQEELFVVDDEGRLLDEPEVTEEITPIQPGPFGRRRSFDGRNWPPGVDLIHDEYGRGWVWGSGRGIVTCRFEYRGSEIGRVKSVPQDDEALHPAHPLPLAWQPPQEDVPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKK4</accession>
    <name>W4TKK4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69326">
        <property type="protein sequence ID" value="GAE69326"/>
        <property type="gene ID" value="JCM18909_2530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6353" checksum="6DA0929DDB86BA8A" modified="2014-03-19" version="1">MELVRRLFDGTGSPAEVVLRWAAVATLPAFLVDTYLVKKLRREYVVVGGHPVERGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN9</accession>
    <name>W4TKN9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68724">
        <property type="protein sequence ID" value="GAE68724"/>
        <property type="gene ID" value="JCM18909_1878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="10816" checksum="D7AEF6561B9A002E" modified="2014-03-19" version="1">MMAMLINAVALVSMGLVHHFGLLAVAVLVNGMAGAVYGIARQNYLTVAIPYRYRARALSTLGGVFRVGWFVGPMAGSWILREAPCHGPTDLHPLPVFSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV0</accession>
    <name>W4TKV0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-keto-2-deoxygluconokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69575">
        <property type="protein sequence ID" value="GAE69575"/>
        <property type="gene ID" value="JCM18909_2808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11055" checksum="1828C8F9BFC41DE1" modified="2014-03-19" version="1">MAFGDWLVSTASYDAHCRALEVRGKAEHTVLDLDYRSMFWQSAAKAHEAVSAVLPHVTVAIGNREECEMAVGESDPDRAAHALLDAGVQLAVVKQGPKVPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL39</accession>
    <name>W4TL39_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68879">
        <property type="protein sequence ID" value="GAE68879"/>
        <property type="gene ID" value="JCM18909_2049"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022307">
        <property type="entry name" value="Helicase_put_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="DUF1998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03817">
        <property type="entry name" value="DECH_helic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="188"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="663" mass="71990" checksum="0D22593024EDFC38" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL43</accession>
    <name>W4TL43_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JCM18909_2939</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69690">
        <property type="protein sequence ID" value="GAE69690"/>
        <property type="gene ID" value="JCM18909_2939"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="HSDR_N" evidence="12">
        <location>
            <begin position="34"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SWI2_SNF2" evidence="13">
        <location>
            <begin position="297"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE69690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="510" mass="57484" checksum="5D84068A597CECF8" modified="2014-03-19" version="1">MSESSPRVYDSIVMSDQSTVVAEYAPADSRCEDYQSEAALEREFIRILESQAYEYLPIHRERDLVVNLRRQLEDLNGFTFSENEWSSFYSTCIASANDSIEDKTVRLQEDEVQLLRRDDGTTKNVKLIDKSNIHNNRLQVINQYQVGAERDGSRYDNRYDVTILVNGLPMVHVELKRRGVAIREAFNQIRRYQRDSFWAGSGLFEYVQLFVISNGTQIKYYSNTTRSQHLKDQDKLSAKKTSNSFEFTSWWADAQNKPIQDLEAFAKTFFAKHTLLNILTKYCVLTVDHMLLVMRPYQIVATERILQRIATSTNYRQLGTVAAGGYIWHTTGSGKTLTSLKTAQLATRMSGIDKVLFVVDRKDLDYQTMREYDRFEKKVLPTPTPQRQSSRPSLRIRVPRSSSRRSRSSVFSFAATITTTSTTSTSSSSSMSATVPSSVTCTPTSPALSSVTTSLVSPVRPSLRPTVEARAIRSCVLPGRPSGTSCTLTPSSTLSMTRTCCLSASTTTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLB4</accession>
    <name>W4TLB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69317">
        <property type="protein sequence ID" value="GAE69317"/>
        <property type="gene ID" value="JCM18909_2518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="131"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="330" mass="35534" checksum="F63D046D7A06F362" modified="2014-03-19" version="1">MANLRAGMVGIGSMGKNHVRNLRAIDGVDLVAIADASGKDPFGVAGDLPILPDVDAVIETGVDYCVVAAPTKFHEEIGLKLAEAGVHALIEKPLAYDTAAATRLAEAFESKGLVGAVGHIERYNPALQSLRKRLENGDLGDLYQVATRRQGPFPARIADVGVVKDLASHDIDLTAWVTQREFELVAARTMFKAGRDYEDMVSATCQLSGGLMSNHLVNWLTPTKERRTFVTGEKGMFVADTLTADLTFYSNAKVATVWDDIANFRGVAEGDVTRFAIPKPEPLRTEHENFRDAVLGKESDIVTMAQGATVVQVCEAMITSAATGEFVKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI9</accession>
    <name>W4TLI9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="21" type="ORF">JCM18909_2849</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69611">
        <property type="protein sequence ID" value="GAE69611"/>
        <property type="gene ID" value="JCM18909_2849"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GAE69611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="289" mass="29597" checksum="30DDB2BF412C8CF0" modified="2014-03-19" version="1">MCGRDPQEVGMTDEQHPDLGRLGPLRGVAEALSLFTILPGPYLNDIDRPLARRAITAFPWLGLCLGVVAGGIVALVLGLGAGPWLAGVLALCWLAGATGGFHLDGVADTADGLGSRAAPEKALMIMKKSDIGPMGVMSIVLVLLVDAAAVVSLAGTVGSGAWWRVAILVGLGPALARAAILLATMTGVPCARPGGFGSLVAGVTTPRSAAINLTALGCVCALAGLVARGWMWCLVTVSCATLTLLIARGWIHHLVRRLSGMTGDTFGSINEVTQMTFWVLTALTVAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLQ2</accession>
    <name>W4TLQ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69109">
        <property type="protein sequence ID" value="GAE69109"/>
        <property type="gene ID" value="JCM18909_2297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5181" checksum="8FDC277D703582CD" modified="2014-03-19" version="1">MALATTPPGGHGHNYHSEFIPVWAAVLGISCNDNTVAAIPKAIPKTSAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLR1</accession>
    <name>W4TLR1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type I restriction-modification system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69691">
        <property type="protein sequence ID" value="GAE69691"/>
        <property type="gene ID" value="JCM18909_2940"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="181" mass="20518" checksum="02002D2FAFDEB07C" modified="2014-03-19" version="1">MRVGSPEDRQVAGIDTEMALMAPERIRQIVQYTLEHFAQKTKRTSSYEYSVVTNVTESTCSRRAAEALRERRVHGFNAIFATASIDAARRYYNEFQRQQEELAPDKRLKIAIIYSYGANEATDDGILDDEAYDTESLSEDLRAFLENAIQDYNDLFGTSYDTTAEKVPELLQGPLATAQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS1</accession>
    <name>W4TLS1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-ribulose-5-phosphate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69701">
        <property type="protein sequence ID" value="GAE69701"/>
        <property type="gene ID" value="JCM18909_2950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10584" checksum="EFF46D7F7B8A932F" modified="2014-03-19" version="1">MLYDAMTPDDMVVVDLDGKVVEGRRGPSSDTASHLYVYRRRDDIRSIIHTHSTFATAWAATGQDIPCAVTAIADEFGGPVPCGDYARLALNRLVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLV5</accession>
    <name>W4TLV5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation elongation factor LepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69731">
        <property type="protein sequence ID" value="GAE69731"/>
        <property type="gene ID" value="JCM18909_2980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5192" checksum="0FE1316FA2D495DE" modified="2014-03-19" version="1">MSAPQPGSTDPAVIRNFCIIAHIDHGKSTLADRMLQITGSLTSAVLAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW5</accession>
    <name>W4TLW5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69184">
        <property type="protein sequence ID" value="GAE69184"/>
        <property type="gene ID" value="JCM18909_2375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="210" mass="23350" checksum="10B2EB735AC0EB5B" modified="2014-03-19" version="1">MDADGSHQPEQLPLLLEALKQADMVKGSRYVKGGSVVNWPKYRELISRGGGLWTRMCLGIGVKDPTGGFNAFRANTLRAIGLDDVASAGYCFQLDLTWRTLKKGMTVAEVPIEFIEREYGSSKMSKNIVIEALLRTTMWGFDYRSHQLKDLSHVPWTELKRSPETSKSVVLATDQTCAPWITSRPRGAPRRCTGSAGLILLTDFIQPFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY1</accession>
    <name>W4TLY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Kup system potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69532">
        <property type="protein sequence ID" value="GAE69532"/>
        <property type="gene ID" value="JCM18909_2758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11968" checksum="3C69773200A15829" modified="2014-03-19" version="1">MAKATQPIADREPIRSMKPGLALAALGIVFGDIGTSVLYSLQTVFSMENHAVRPTHGDVMGIISMIFWSILLVVCVKYVIFVMRADNDGEGGILALMAWCVGSWLATRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM10</accession>
    <name>W4TM10_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-S5p-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69781">
        <property type="protein sequence ID" value="GAE69781"/>
        <property type="gene ID" value="JCM18909_3033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15701" checksum="96E2482341BC6B44" modified="2014-03-19" version="1">MAGPIILPQPRHYAPYRTIDGVVDLVWICDVVLNGYWVASAYAGRGVAPTAVALACDYVFQVMGLHRVEICVRPENTKSLRVVEKLGLAEEGMRPAYLHIDGQWRDHRVFRLLTDDYPDGVLRNYLVTHLLPGAAVGEDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM15</accession>
    <name>W4TM15_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70020">
        <property type="protein sequence ID" value="GAE70020"/>
        <property type="gene ID" value="JCM18909_3300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5816" checksum="A1014332F51EF473" modified="2014-03-19" version="1">MSIDNGTLFIVDRVQVFLRHHHVNESPPARRIQRETRMPSRCLISCRNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM39</accession>
    <name>W4TM39_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70045">
        <property type="protein sequence ID" value="GAE70045"/>
        <property type="gene ID" value="JCM18909_3328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6380" checksum="8A531D8DA205ABA8" modified="2014-03-19" version="1">MVDLVAKTYANYKTSKAINPPNQFLAWPGTRNRIIALPAALFGRGKWKRRFEMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM57</accession>
    <name>W4TM57_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69816">
        <property type="protein sequence ID" value="GAE69816"/>
        <property type="gene ID" value="JCM18909_3071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15424" checksum="A5C8CFB0685D7DF5" modified="2014-03-19" version="1">MIAGRHIPVHHADTIIFCISAALFAVSVALGLQFSRRELGPPLVDRSRTMRTVAGDVVDGFRYLGKVPLVGHSLTLIGAQRVLFGVYSVAMILGYRNRFHVQSDINGAMADMTVWAVAMGAGFVLSAGFMPMLVHRLGMRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH6</accession>
    <name>W4TMH6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">An allosteric effector of glucose-6-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69394">
        <property type="protein sequence ID" value="GAE69394"/>
        <property type="gene ID" value="JCM18909_2603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="16756" checksum="6290021F37088E10" modified="2014-03-19" version="1">MIVTLNDTTASKIGGAIVEARRTVGSGSGLVHTLICICDSSHFDAAFEAARDAARQHPSRLLMVVTTRSRKDKLDAEVHAGEGTPGDVIVLRFSGAMAKRPASVILPLLLSDSPVIAWWPFSGPDDLASDSIGALADRRITDSAAAKDPCKASYAVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMH8</accession>
    <name>W4TMH8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalt-precorrin-6y C5-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69623">
        <property type="protein sequence ID" value="GAE69623"/>
        <property type="gene ID" value="JCM18909_2862"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13490" checksum="8D9BE69C349ACE8F" modified="2014-03-19" version="1">MTHDPDTSLLGRTPGLAEEHFAHDGLITKHAVRAVALAALRPMPGQLLWDLGTGAGSIAVEWCRTDPTCRAIGLERKAERAANARTNASELTLPGQFDVIDADLARGLPEGLPDPDAVFIGGGATKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML7</accession>
    <name>W4TML7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aspartate transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69668">
        <property type="protein sequence ID" value="GAE69668"/>
        <property type="gene ID" value="JCM18909_2913"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024551">
        <property type="entry name" value="AspAT_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12897">
        <property type="entry name" value="Asp_aminotransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="213" mass="22979" checksum="C59AAA201EA63C5D" modified="2014-03-19" version="1">MLQWAEEAGNPDRVFELASTSKITFAGDGVSFLASSKANLDWYLGHAVIRSIGPDKVNQLRHAQYLRDAEGVRKLMRAHRKILAPKFAVVNEILTHRLGGRGVASWTHPTGGYFISLDVMDGTASRVVALAKEAGIALTPAGASHPLHRDPHDRTIRLAPSFPGMDELRAAIEGVSTCVLLAASEKLLKSGPQDRAAGMTAANHPMDGWQEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN01</accession>
    <name>W4TN01_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70101">
        <property type="protein sequence ID" value="GAE70101"/>
        <property type="gene ID" value="JCM18909_3391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848838" evidence="2">
        <location>
            <begin position="29"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="235" mass="24336" checksum="07B53129052C7C32" modified="2014-03-19" version="1">MSAKYRRALALTSVLVISTSILNPPVCPTPTPWSVSAAHAAPPGATPPGNLTMNASLDRSGTVQVKGALRTHTKRPVSGALINLAIDGKPLAVGVTHDNGSWSGAFRLPPTMQTGAHELSATFDGTEGIGAASASGTFSIGAQPTVLTAAVKPTTAAPGALLNVNGTVTLPTHRRVTDSQVVILLGTDGQAALTAPIDSQAIIKPHSRCRWMPQTARSRSRSNWSIPGMESRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN72</accession>
    <name>W4TN72_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription termination factor Rho</fullName>
            <ecNumber evidence="3">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rho</name>
        <name evidence="5" type="ORF">JCM18909_3248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69972">
        <property type="protein sequence ID" value="GAE69972"/>
        <property type="gene ID" value="JCM18909_3248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 3" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="268" mass="29588" checksum="77566D5456F22FB0" modified="2014-03-19" version="1">MTGRIIDLVSPIGKGQRGLIVSPPKAGKTMIMQSIANSITRNNPEVHLMVVLVDERPEEVTDFQRTVSGEVVASTFDRPADDHTQLSELAIERAKRLVELGHDVVILLDGITRLGRAYNLAAPASGRILSGGVDSAALYPPKKFFGAARNIEHGGSLTILATALVETGSKMDEVIFEEFKGTGNMELRLRREFANKRLFPAIDVDASGTRREELLLSREETAIMWKLRRVLSGLEGSQALEMMLSRLRKTQTNVEFLYTISKTTPNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB3</accession>
    <name>W4TNB3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-keto-3-deoxygluconate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69704">
        <property type="protein sequence ID" value="GAE69704"/>
        <property type="gene ID" value="JCM18909_2953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24828" checksum="69DF555702A9DF16" modified="2014-03-19" version="1">MEPGEYPMPARVLYDREHTPFRDVTVEDLDWEALLDTRLVFVTGITAALTENTAAVVRHFVDEAHRRGIAVALDVNYRSLLWGPEYAREVLEPIARMSNIVFCSVRDGKAVFGIESDGEQACRELRELFEVPTVVSTDQINGVYFSDAERGDCTFPVVQVPVIDRPGAGDSFVAGTLHGYLGGDVVQGIHYGQRTSAYALTHYGDLTRVSPSELNIPPNTDILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNE3</accession>
    <name>W4TNE3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trypsin-like serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S01.513"/>
    <dbReference type="EnsemblBacteria" id="GAE70261">
        <property type="protein sequence ID" value="GAE70261"/>
        <property type="gene ID" value="JCM18909_3564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="363" mass="37579" checksum="14F737381FEB8C9B" modified="2014-03-19" version="1">MIGGVWVGLWASGDIVSRITNNSSSWLATGPLRFGVVLVIVEVIHGLCNGLARRICHASETAGLGALDRIGGALLSATATALVVAVGATALAPLLPPQWTQAIDESAVINTTNRAIPPQINHEAARLIGQMADTFPKVFTGQDPRLPGDAPDDSAANSPGVRQAARSIVKVRSLSHQCDRASEGTGWVSSPHRVVTNAHVVAGSDTVTVQVGGQGARLRARVVAYDPDLDLAVLAVPKLKAPALTMTSSVDAGDSTVIAGFPLDGPYTVNAARVRGAITARGENIYGDDDVVREILSLRGTVQPGNSGGPLLTTDGKVAGTIFARSTSQPQTGYALTNRETRQLIRSGTYDSTPASTGRCSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNN3</accession>
    <name>W4TNN3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70003">
        <property type="protein sequence ID" value="GAE70003"/>
        <property type="gene ID" value="JCM18909_3281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="13911" checksum="5CBFFE1643F03901" modified="2014-03-19" version="1">MAETFRSELTHDFIQSCGFLVIGAAIAATVKVCVPTAWMQALTTNVVVETAVLSLLAVIVALCSEADAFMAVSLTSFSPTAQLAFLAIGPVVDVKLMAMEGGAFGAGFLKRFVPLATCCCFVSAILIGALIFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP2</accession>
    <name>W4TNP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70013">
        <property type="protein sequence ID" value="GAE70013"/>
        <property type="gene ID" value="JCM18909_3292"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5995" checksum="1C13D8FE56755BCF" modified="2014-03-19" version="1">MTSYISIRPDLENAGASWVDKKLFRCPGNGWVLLTSRNPNDLPAFTKGLVDEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR9</accession>
    <name>W4TNR9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69854">
        <property type="protein sequence ID" value="GAE69854"/>
        <property type="gene ID" value="JCM18909_3113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="3">
        <location>
            <begin position="62"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="287" mass="31228" checksum="376769EAE76A2B34" modified="2014-03-19" version="1">MRFCQSFMTELYRHLGEHTDVPAGDIGVGSREIGFLFGQYKRITNRHESGVLTGKGLTWGGSLVRTEATGYGTVFFVQRMLATNGKSLDGLRVTVSGSGNVAIYAIEKVQDLGATVVACSDSSGYVVDEKGIDVALLKQIKEVERARICEYAARRDSATFHSDGLIWDVPVDVALPCATQNELNGQAAATSSATVWSLSLKVPTCPALLRRCIPSRTPASFSPRVRHLMRVASLLRPSRCNRMPRATPGISTRPKLDCSRLWPTFTIVASRPPTNMATLGITLWAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV0</accession>
    <name>W4TNV0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_3515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70217">
        <property type="protein sequence ID" value="GAE70217"/>
        <property type="gene ID" value="JCM18909_3515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="216" mass="24278" checksum="A6092CAF1BB7B08C" modified="2014-03-19" version="1">MSDLLDDLEWRGLVADSTDREALEAHLAQGPVTFYVGFDPTAKSLHIGHLVQLMLVRALQERGHKPLLLVGGATGLIGDPKMSGERHMNDREVVAEWVESIKDQVSQYVDTDGRNAAQIVNNYDWTVKYTALDLLRDVGKHFSVNRMLARDVVARRLESGISYTEFSYVLLQSLDFYELHKRYGCTLQTGAQDQWGNITAGAEFIRKTTGDVVHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPC6</accession>
    <name>W4TPC6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000053">
        <property type="protein sequence ID" value="GAE70571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70571">
        <property type="protein sequence ID" value="GAE70571"/>
        <property type="gene ID" value="JCM18909_3919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7444" checksum="B773D73570800A1A" modified="2014-03-19" version="1">MRAGIFGAALELADEAGLGWRLANIDADLVQGIHAVGGLLRAPRSEGLVGHVYDDPHPAAAGAFDRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ69</accession>
    <name>W4TQ69_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ala_racemase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70533">
        <property type="protein sequence ID" value="GAE70533"/>
        <property type="gene ID" value="JCM18909_3871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="342" mass="37325" checksum="CC7715722E6A93AB" modified="2014-03-19" version="1">MLKLTIDAQRWRNHLTTFAKSCPGIVPVTKGNGYGFGHELLVQESQRLGIDILAVGVAQEVASVRQYGWDKDVIVLNPWRPGDEIATGLLNDPKVITTISRREDIATVRDLAPSASILVEVETSMHRHGVPADEVAALDLDGFDLRGWTIHLPSGASLDEGREMARIVKQHPLASRGIWFSHLSCDDYIALSKELDVPVRMRVGTRLWLGDANAYRVTGIVLDVRWLPKRTPVGYHRVKTHTDGYIVVVSGGTAHGVALSAPISARSLRQWLIPGAEALQQMVGRVISPFTIAGKKAVFAEPPHMHSSLVFVGGPGEPTHVGDEVPVNVRMATATFDEISLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ88</accession>
    <name>W4TQ88_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Alanine dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_4090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reductive amination of pyruvate to L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="3 6"/>
    <dbReference type="EMBL" id="BAVM01000074">
        <property type="protein sequence ID" value="GAE70707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70707">
        <property type="protein sequence ID" value="GAE70707"/>
        <property type="gene ID" value="JCM18909_4090"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00527">
        <property type="reaction ID" value="UER00585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="10">
        <location>
            <begin position="150"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE70707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="371" mass="38201" checksum="20B5865DEAFE9211" modified="2014-03-19" version="1">MRVGVPTEVKDNEFRVAVTPAGVHALVGRGHEVLVQAGAGVGSGISDSDFVGAGARVVGDVESVWGDADLVLKVKEPVAEEYGRLHEGLVLFFTYLHLAADEVLTRELLGRGVTSIAYETVELGDHSLPLLSPMSEIAGRLAAQVGANCLLQSAGGRGVLFGGGSGVRRGRVSVLGGGVAGLCAARAAAGMGADVTVFDVDVARMRYIDEVWGGRIGTRFSSPLAVREACGESDVVIGSVLVPGARTPHLVDHETVLGMVPGSVLVDIAVDQGGCFEDSHPTTHADPTFVVGGSVFYCVANMPGAVPHTSTYALTNATMRYVLLLADEGWRGACGSRGDLRCGLATCGGKLLSVPVGEALGIECVPVSEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQK8</accession>
    <name>W4TQK8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_4071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000067">
        <property type="protein sequence ID" value="GAE70693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70693">
        <property type="protein sequence ID" value="GAE70693"/>
        <property type="gene ID" value="JCM18909_4071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11201" checksum="5756E04588371E40" modified="2014-03-19" version="1">MQGIIVSKPQDLTRSTSDSGAEAEHPRVVVAEDEALIRLDLVELLEEHGYEIVGQASDGEEAVRLANELEPDLIVMDVKMPKMDASLRPTRLPKTVFVLSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQN7</accession>
    <name>W4TQN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-isopropylmalate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_4112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000094">
        <property type="protein sequence ID" value="GAE70723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70723">
        <property type="protein sequence ID" value="GAE70723"/>
        <property type="gene ID" value="JCM18909_4112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="4848" checksum="E7EA838A3D2397EF" modified="2014-03-19" version="1">MHIIGPQLGLTQPGMTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQZ8</accession>
    <name>W4TQZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II restriction enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000063">
        <property type="protein sequence ID" value="GAE70669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70669">
        <property type="protein sequence ID" value="GAE70669"/>
        <property type="gene ID" value="JCM18909_4044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="210" mass="23347" checksum="B91A64559C52180E" modified="2014-03-19" version="1">MPSSDALIVVEDWISEHFFTTDARKESFQKLVLDRRKQWDGEDVPTTRTRFTERASKLATMLAALYSEDLDEAARAEAAEQAHEKLLRMLGYSTGEFRIRRDGPVRWFSTAGIEQSALAVVTARPVETPDQLMVKDARTLPTPWRPSEDAPDSEEVHSASRLVSTLFAPKEGQSFALIMAGRWLVVAEKDGGPKGGTWPSTCRPSPSGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEE3</accession>
    <name>W4TEE3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67156">
        <property type="protein sequence ID" value="GAE67156"/>
        <property type="gene ID" value="JCM18909_197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5372" checksum="5378D129AECCADEA" modified="2014-03-19" version="1">MHAGAEIVAAPLGDDPVLASLAFERYCSAAMGWYHNPPTTPPHPPEFHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEL8</accession>
    <name>W4TEL8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67236">
        <property type="protein sequence ID" value="GAE67236"/>
        <property type="gene ID" value="JCM18909_281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3416" evidence="2">
        <location>
            <begin position="94"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23181" checksum="716E84AF3C860A49" modified="2014-03-19" version="1">MWRINRRDRRHDENGSDDEEVQVTPSSPEPSPEPMAPASPADSPKSAPTPEPSLVPPEFPAPRRAAEHAFGDNALFTATSAIGSPGCPPLRGFGRIPVHNVRPEVESGHLPIYSVVDEEFEVTANVFREGHDAGGASVVLTDPEGNRHLTDMHQVEPWGLDIWKARVSADIEGDWTMHVEGWSDTWGTWHHNANAKLAAAIDVELVCAEGHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEM6</accession>
    <name>W4TEM6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartyl-tRNA(Asn) amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67246">
        <property type="protein sequence ID" value="GAE67246"/>
        <property type="gene ID" value="JCM18909_291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="19941" checksum="3300B03D3D11F556" modified="2014-03-19" version="1">MNELLTLTAAELGERIAARQISSEEVTQAHLDRISEVDGDIHAFLLVDHAGALDAARRIDARIADGEPLGPLAGVPLAVKDLFCTKGIATTASSRMLEGWIPPYDSTIVTRCKDAGMVILGKTNLDEFAMGSSTETSAFGLPIIPGTLNGYRVVPVVVQRLAWLPSRPRWLWALIPVARSANLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEQ1</accession>
    <name>W4TEQ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator of pyridoxine metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_32</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67002">
        <property type="protein sequence ID" value="GAE67002"/>
        <property type="gene ID" value="JCM18909_32"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="10822" checksum="06AD8E93530B1209" modified="2014-03-19" version="1">MRQVYRRRRRTVIDTLGSLPGTTLQPIDGGLHAVLVFDGSEDDVVQRCRQEGVGVTPLSTYWGSSDAGVAGIVLGFGSHDDATLASALKIIAGVVTAHGRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF20</accession>
    <name>W4TF20_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67555">
        <property type="protein sequence ID" value="GAE67555"/>
        <property type="gene ID" value="JCM18909_622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="187" mass="21082" checksum="2A6CFE9E9198F99A" modified="2014-03-19" version="1">MYSDDGGQTWNLGKSPNDERELFGKIVSSRNLNDDRGSTHESALVETPDGVVHSFMRNQHPSGRVAHAASVDGGETWGEVTFVEQLTEIFSQPNAISVRDEFGTESVVFANASMMLPFRGCGVLRQSFDGGKTWPHNRVLNPRHHVYQCMTQQDEQTLLVLWEREWQGLFLTEVPLSWLTTSRSTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF22</accession>
    <name>W4TF22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteroides aerotolerance operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_48</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67018">
        <property type="protein sequence ID" value="GAE67018"/>
        <property type="gene ID" value="JCM18909_48"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8571" checksum="1D3B10E84EBA8FC2" modified="2014-03-19" version="1">MHSSVGYEPVRKEVTATWAFYALCFAVVSGLATLSVAVRWHDDPDCFWTPWTTVVAPGSGSLPRCLPCSGDVASPAAPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF51</accession>
    <name>W4TF51_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyco_hydro_85 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67590">
        <property type="protein sequence ID" value="GAE67590"/>
        <property type="gene ID" value="JCM18909_662"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="Glyco_hydro_85"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_85" evidence="3">
        <location>
            <begin position="16"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="484" mass="52363" checksum="D4674210741C9D8D" modified="2014-03-19" version="1">MTELPSLYESRRNHSPKASVALFTPSDMYQRGLADVVKPKGADKDVPLFQQDPYQWMVAERERMYFSGVTSNPKDTGAHPGHSRPEVGVADSSSWVGAADFTPARSVIGGRRFHTDFNTGHGMKWYSAGDVSAAASWTDMDAQSILPSWQWWIDTEGTRPSVDFDYGPSDRHKDVHGAPVSLPYHQVGAWRGGSSLVVHGTMSKTTTLRLFKTRLAMTADTSMPITFRKSSKDHGTMKAALVFADDPGRVVTVDVPGSGVKGGWHTSTLRLGRFAGRTLTTLGLQFAPAPDYQMNVGAISVRVGSGVPAAPSEVHIDTVYDDGQAILSWHAAPFDDVAGYVVESMGPDGKIVHLASGYTDLAYLKAVPKKTGKVTFRVRAVGHDGQMSAPSTVSYDYSAQPRHIKVAEAATASKLLTDAVRPGVLDVTWDAKGVRASTCRVDVHLVDIAKDDIDNQPTASTCPALPAVPRCRFRYARGTPMTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS7</accession>
    <name>W4TFS7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66979">
        <property type="protein sequence ID" value="GAE66979"/>
        <property type="gene ID" value="JCM18909_8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE66979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9053" checksum="BF4C7C55F5473ADC" modified="2014-03-19" version="1">MVTELAESCGNPGTREASSYHDDVHLATVRGIDELVLALTTGPRGERIPLGSFAVQFVTNKVAGLLLRRAKDVTGFGTFGSPSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFV5</accession>
    <name>W4TFV5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67402">
        <property type="protein sequence ID" value="GAE67402"/>
        <property type="gene ID" value="JCM18909_460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016867">
        <property type="entry name" value="GcvR"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028103">
        <property type="entry name" value="GcvR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="60"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15171" checksum="EA6C24C71374F681" modified="2014-03-19" version="1">MVDSRMARLAGAFAGIVLVDVKSSKVEPLKADLAGLEVKGLRVTVTDTTPQQDEGEAVLVVHLVGHDHPGIIHKVTATMARLGVTIDDLSTGLREAPMGDGILFEAQVQCRITNATTLDDLRSELEAIATEIMVDIDLVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY4</accession>
    <name>W4TFY4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylmalonyl-CoA mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67417">
        <property type="protein sequence ID" value="GAE67417"/>
        <property type="gene ID" value="JCM18909_476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="7">
        <location>
            <begin position="110"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="242" mass="26257" checksum="7AB96042EB4A9911" modified="2014-03-19" version="1">MLKEQKAKLEQLRANRDEEACQAALEKITWAAANPDPSDPDRNLLKLCIDAGRADASVGEMSDAMEKVFGRYTARIRTIEGVYSKAAGNSASTKKVHELIKRFEEKEGRRPRIMIAKMGQDGHDRGQKVVATAYADLGMDVDVGPLFQTPEETARQAVEGDVHVVGVSSLAAGHLTLVPALRKELDKLGRSDIMIVVGGVIPTQDFDELRKDGAAAIYPPGTVIPDAAVELMEKLLAAHNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG27</accession>
    <name>W4TG27_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67472">
        <property type="protein sequence ID" value="GAE67472"/>
        <property type="gene ID" value="JCM18909_534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="10648" checksum="E8C7E77F9BD1A582" modified="2014-03-19" version="1">MAWLLVVVVIIVIGLAVMAGSGKFGQVPPVVDDRPAPDLPEGDLSAESLRSVRFAVVPRGYSMSQVDQLLDRLASQMETGQGPDLTTTGRSIPDATAPDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG53</accession>
    <name>W4TG53_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67507">
        <property type="protein sequence ID" value="GAE67507"/>
        <property type="gene ID" value="JCM18909_570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="47"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="165" mass="17812" checksum="2A9057C71BE70AA0" modified="2014-03-19" version="1">MSAIKPYPQSPRRHVPGNIARPPYVGLGDVPETYDGSHVQSAETIAAMEEAGRIACGAMYEAGKAVEPGVTTDELDHIAHEYMCDHGAYPSTLDYRNYPKSCCTSVNEVICHGIPDSRPLEDGDIVKIDVTAYKKMACTATTATPSVAATLTKHLWTSSTILSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA2</accession>
    <name>W4TGA2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67985">
        <property type="protein sequence ID" value="GAE67985"/>
        <property type="gene ID" value="JCM18909_1088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="361" mass="38656" checksum="9B1508D9876664EE" modified="2014-03-19" version="1">MTPQSLSMITRLFPPEKRGAAMGLWGATAGVASFVGPVLGGILVDTLGWEWIFFVNVPVTVIGLWLAIRNVPALETHGHAFDWCGVVLSGIGMTLLVFGIQEGEQYNWGTITGIISVPLLVVLGVVFMVLFVVSQTQWAQTRLHARSTNFEPLVPLRLFTKRNFTLANIAIFLVGMLVTAYFLPTAIYLQNVRGKSPTVAALLLIPTAVVSGVLSPVVGRVLQHRRSGRMAAIGVSLYAISSIGWWLFTVPSTGLWVFPLLSAITGVGAALTWSPISLVGTDDLGQADAGAGSGVYNATRQVGSALGSAFIAMMMDARIMARHDLGRGLGESMFITITAGTICVIVCAFFANFQRSRQRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGB4</accession>
    <name>W4TGB4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucoside bgl operon antiterminator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67995">
        <property type="protein sequence ID" value="GAE67995"/>
        <property type="gene ID" value="JCM18909_1100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036650">
        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00874">
        <property type="entry name" value="PRD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63520">
        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51372">
        <property type="entry name" value="PRD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="2">
        <location>
            <begin position="99"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="2">
        <location>
            <begin position="205"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="317" mass="35649" checksum="4A57357DFCD23BED" modified="2014-03-19" version="1">MIRRQYSQSPQDDPVQRPDRSRHATTKQGSLKPGHVIVKKIYNNNVLLGVNGSGTEMVVNARGIAYGRHRGEIVDASSAQRYVAEGAYRTTAIASLLTNATHTEVRVAQAIVELAREELGTPHARRMMLPILDHLVAAVHRAKQGAVIDFPLEWEVRQLYPDEAELGRRAVEIVDGALGIHLQPEEWVAFSLHFINQRWDSKDVSQTMSMTQTICDVFTELEDLWHVEIDRSSMSASRFVTHLRYLFARASDNKQLSHVDLDIVGLMSDRYPEATLAASHMAEHISKAIGNDLTEAEINYIALHTTRLYNEVMGMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGF9</accession>
    <name>W4TGF9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67617">
        <property type="protein sequence ID" value="GAE67617"/>
        <property type="gene ID" value="JCM18909_690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="256" mass="27982" checksum="00B243581264C2E9" modified="2014-03-19" version="1">MTHHAFQIKPHEKVGLMCEIANRSGHTIVFARTQRGASRMAEQLREAGVMAGALHGGLTQGARARVLAAFKDGSLPVLVATDVAARGIDVDDVTLVLQVDPPMNFKDYLHRSGRTARAGHDGAVVSLVLPHQRRTMARLYRQAGVKPVEAQVTRGDDHVAEVAGCSPALGAPIDEKDYEALVAPKQQRGKKARDGKPRRGKGGRNRGGRGFDGGRHRGHDSRDHHDRGHDSRGHNFRGRDRRDIEAKYGRSGNDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH9</accession>
    <name>W4TGH9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67518">
        <property type="protein sequence ID" value="GAE67518"/>
        <property type="gene ID" value="JCM18909_582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="302" mass="32273" checksum="3F81AB4CD8E73FA4" modified="2014-03-19" version="1">MAADTPKGRIVHRLIRHRIALMSAHTNADAAVGGVNDVLARLLGVTVERPLEPAAQPVDLWGVQVPVDAAEALRNALFGVGAGQCDGYDLCSFETVGRGQFRPLSGSHPALGTTNQVETVEEVRIHVVAPAMMRSTIRKALVDAHPYEVPAYDVKTIDSRSRPGPATPGIGRIGHLDEPMTLRSFTQRVSERLPRTVWGVRAAGNPDQLITTVALCSGAGDSLLDAAAASGADVYLTSDLRHHPADEHLRANGPALIDTAHWASESPWCADVARRLHDELGLPCQDLGIRTDPWTIGTTVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGK5</accession>
    <name>W4TGK5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67548">
        <property type="protein sequence ID" value="GAE67548"/>
        <property type="gene ID" value="JCM18909_615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19462" checksum="CE04B402AA297D32" modified="2014-03-19" version="1">MSFFWPTIAVIMTTVTRTLIMPSPIDLKIYRDCVRAMLDDPRTLYTASSVSGLGFTYPPFAAIALIPLALIPSLTVTVLHYAVSAIALVVMIDLIWQRCGHTSRPFLTAVLIGVLNFSEPIGKTFVYGQVNLQLALLVIVDVFLLPESGAEWGLEWPPVQAHSGHLRPLVPRYRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGM5</accession>
    <name>W4TGM5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67304">
        <property type="protein sequence ID" value="GAE67304"/>
        <property type="gene ID" value="JCM18909_350"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11021" checksum="1932DD8492C084DF" modified="2014-03-19" version="1">MSGHSKWATTKHKKAAIDAKRGKLFARLIKNIEVAARLGGGDPSGNPTLYDAIQKAKKRARFLTTTSPVLLSVGLVRALTPSITRRLCTRPMAPLALPSLSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP8</accession>
    <name>W4TGP8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67329">
        <property type="protein sequence ID" value="GAE67329"/>
        <property type="gene ID" value="JCM18909_376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7881" checksum="3D90706A89F6E0EF" modified="2014-03-19" version="1">MGRKVIYHHARYSERFKRDAVALYGDNEELALLVAAKELGINRTTLIDWNSKYGTGKRIRKQAQAATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGT0</accession>
    <name>W4TGT0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CsbD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0337 (CsbD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68175">
        <property type="protein sequence ID" value="GAE68175"/>
        <property type="gene ID" value="JCM18909_1294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008462">
        <property type="entry name" value="CsbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05532">
        <property type="entry name" value="CsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7368" checksum="3B69356962E14D5D" modified="2014-03-19" version="1">MGLSDKINSKSDEAVGAAKEKIGGLTDDSDLKSEGADQKASGKVAQKVEDVKDKANDLKHNVQAAADKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH73</accession>
    <name>W4TH73_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67479">
        <property type="protein sequence ID" value="GAE67479"/>
        <property type="gene ID" value="JCM18909_541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="131" mass="13833" checksum="D22B016FCBF09E5F" modified="2014-03-19" version="1">MAVKDAKGLVVESATVMANTTLAYYSGDDAITPALLSVGGVGLVGTSTHFTGRRMHEVIDAYVDGRIDEALSTYREILPVLTGVFAAQGATMVKAGLAHQGFTVGKVRPPQTMPTSEQAETFFGVLDRTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH79</accession>
    <name>W4TH79_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GtrA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68141">
        <property type="protein sequence ID" value="GAE68141"/>
        <property type="gene ID" value="JCM18909_1259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="14663" checksum="D94B66DA57A5F42B" modified="2014-03-19" version="1">MITEPTAPTRRRIKKRHLIEFIKFGVVGGSGFLVNIIVAIIMNKANGGTEHAQDILFNLAGTRWNFRFTSLVWLVGFVVANITNFQLNRSWTFKREYRRGWWREFWPFFCRRVDSRHYRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA3</accession>
    <name>W4THA3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Signal peptidase I</fullName>
            <ecNumber evidence="3 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_1285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 5"/>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S26.025"/>
    <dbReference type="EnsemblBacteria" id="GAE68166">
        <property type="protein sequence ID" value="GAE68166"/>
        <property type="gene ID" value="JCM18909_1285"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="39"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="274" mass="29722" checksum="41C7B9A70A461AA1" modified="2014-03-19" version="1">MADDYQARRAANGDTRDSDDATARGEQASGWQRFRSGAIEVVLIVVGALIISAVLRGFVAQMFVIPSKSMQNTLQVGDRVIAVKAADFHRGDVVVFKDTEHWLPAAQDRRSVPGQILEFVGLLPNKSSNYLIKRVIGMPGDTVACCNVNGQVTVNGKALDERSYLYSENGEMVKPSAMEFRVTVPRGRMFVLGDHRNASGDSRYHLQDLDPGEYTGAPAFVPLDDVVGPAKAILMPLNRIEGLGTPDTFRGIPDRSSSAPARARICVGDTCCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>W4THC8</accession>
    <name>W4THC8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="2">FGAM synthase</shortName>
            <ecNumber evidence="2">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="2">FGAR amidotransferase II</shortName>
            <shortName evidence="2">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purL</name>
        <name evidence="5" type="ORF">JCM18909_1318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68196">
        <property type="protein sequence ID" value="GAE68196"/>
        <property type="gene ID" value="JCM18909_1318"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="188"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="309"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="482" mass="51189" checksum="8F0167B565DDE9BF" modified="2014-03-19" version="1">MQDFGAAGISCATSELASAGDGGMHVELDRVPLRDPNLAPEEILMSESQERMAAVVRPDRLDRFMEICAHWGVAATVIGEVTDTGRLHIDWQGERIVDVDPRTVAHDGPVLDMPAARPWWIDELNENDANALPRDNSGEGLAGALLALVGSAQLCDRSWITDQYDRFVRGNTVLAQPNDAGMIRIDDNLGIALSLDANGRQTTLNPYLGAQLALCEAYRNVAVSGATPVAVTDCLNYGSPYDPNVMWQFDETILGLVDGCRELGVPVTGGNVSLHNRTGDESIRPTPLVGVLGVIDDVHRRIPSAFAHDGDAVLLLGTTKCEFGGSVYEDVIHAGHLGGMPPMPDLNAEKALAAVMVEASKRGLLSSAHDLSDGGLAQALVESCLQGGLGVSVSLPEGEPSVMLFSETPARAIVSLCGNGYREFKALCQEHGVPTARIGEVIDHGEVEVNGLFSLPLGEIERAWRKPIPTAMGGVTGVSWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF0</accession>
    <name>W4THF0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67863">
        <property type="protein sequence ID" value="GAE67863"/>
        <property type="gene ID" value="JCM18909_954"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="11"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="269"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="615" mass="62938" checksum="3DBE9DC480A5ADC2" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4THH6</accession>
    <name>W4THH6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate-dihydroxyacetone phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68246">
        <property type="protein sequence ID" value="GAE68246"/>
        <property type="gene ID" value="JCM18909_1369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="11"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="218" mass="22209" checksum="C03933B3922CD835" modified="2014-03-19" version="1">MGMLMSEISAATVSEWLKNYSAVISEHANELTDLDRQIGDADHGSNMARGMTAVAALDPEPFASAAELLKKAGMTLVSTVGGASGPLYGTFFLRLSTVIKTDGEPTAQLLADALDAGLAGIVARGKAEVGDKTLVDALSPAVDAAKQVAADDGSAAEALAKAAEAANEGRDATIEMVARRGRASYLGERSKGHQDPGATSMALLVASAAHCLSGANHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ7</accession>
    <name>W4THJ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68271">
        <property type="protein sequence ID" value="GAE68271"/>
        <property type="gene ID" value="JCM18909_1395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9446" checksum="CD96B03A9BF514CC" modified="2014-03-19" version="1">MTPIRAEEILDSLARDEEVHSTRGAKITSWREAERVLAGFPDGRADEGPSAGEASLQGVRLAKQNGWKAPDPNNLPAPAEPVEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM8</accession>
    <name>W4THM8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protoporphyrinogen IX oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68017">
        <property type="protein sequence ID" value="GAE68017"/>
        <property type="gene ID" value="JCM18909_1123"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="21132" checksum="FDDF79F9D2F733CE" modified="2014-03-19" version="1">MNRVATMNISDPQHVDAVVIGGGMAGLVAAWQFTQEGLHPVLVESRGYTGGLIARSTLAGISYDIGAEGWAVRLPDTAELATELGLTVEKPTIAPSWVYFDDACFAMPDNAILGIPANLSDPAVVIALGAKEAAHAAELDRAPMPEDLPRDLGALVASRMGPEVLRRLVTPIAGGIHAADPHLLSADVVSPGLRLPPRPPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR8</accession>
    <name>W4THR8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67963">
        <property type="protein sequence ID" value="GAE67963"/>
        <property type="gene ID" value="JCM18909_1065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5389" checksum="A78B7278587FA31D" modified="2014-03-19" version="1">MTRSLPPEWDDDRRPGGGGNPQGNIAPTDWKVIIVAAVRGRPGVVCAEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI00</accession>
    <name>W4TI00_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease VapC</fullName>
            <shortName evidence="6">RNase VapC</shortName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">vapC</name>
        <name evidence="8" type="ORF">JCM18909_878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67794">
        <property type="protein sequence ID" value="GAE67794"/>
        <property type="gene ID" value="JCM18909_878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 6" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="129" mass="14140" checksum="4C8C2E1F3F51F719" modified="2014-03-19" version="1">MTLVIDASVLAEMLVGSTVGRAAWQQWGGEEFIAPQHLPAEIAHVVRNLSLGHLITDAEAMRILSDFRAFKVELYPVEPLMVDAWEMRHNVSAYDALYVVLARLLGACLLTCDRRLAVAAPDVAVVPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI80</accession>
    <name>W4TI80_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="15">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="15">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="15">AP lyase MutM</shortName>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">mutM</name>
        <name evidence="15" type="synonym">fpg</name>
        <name evidence="19" type="ORF">JCM18909_1256</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68138">
        <property type="protein sequence ID" value="GAE68138"/>
        <property type="gene ID" value="JCM18909_1256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG_CAT" evidence="18">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="FPG-type" evidence="17">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="15">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="15">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="15">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GAE68138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="280" mass="31362" checksum="E0ADBB7CA0136EE9" modified="2014-03-19" version="1">MPELPEVETVRAGLEHSVVPAVVDSVDVVDTRGLRPSGGLEDAVLFETTLSGRQFTAVNRRGKYLWFILDDGTAVLAHLGMSGQFRVSTQYAPQHRHTRIVITLDDGRDLRFLDQRTFGGLTLVPLVDGIPGPVTHIAPDPFEECFDVDEVARRLCARRSAIKRSLLDQTLVSGIGNIYADETLWRVRRHPETPCSRLSQSEAVELLQTARDVMAEAMSQGGTSFDSLYVNVNGESGWFSRVVDAYGREDEPCHRCETPIVRESFMNRSSFRCPRCQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI90</accession>
    <name>W4TI90_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like enzymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68675">
        <property type="protein sequence ID" value="GAE68675"/>
        <property type="gene ID" value="JCM18909_1826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="472"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="737" mass="79489" checksum="806F5E6735308B64" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIA1</accession>
    <name>W4TIA1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67879">
        <property type="protein sequence ID" value="GAE67879"/>
        <property type="gene ID" value="JCM18909_971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="47"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="281" mass="31044" checksum="F00371A4D2FEABB7" modified="2014-03-19" version="1">MMFLTIWWSVWVYPAHAIPTWRRTAVSDAQATERTITSLIPARIDRLPWSTFHTMVIVGLGTAWILDGIEVQIVAANGFAKPLHMSTAEVTAAATFYLLGQVLGALFFGKLTDRIGRKKLFTLTLLVYLLGSGIAGLSFSTWFLYVCRFIAGSGTGGEYSAINSAIDELIPAQYRGRVDLSVNGTYWAGVMLGSVATIYLLDPTKVAEFWGWRIGFFIGPVLGIVVILIRKHIPESPRWMLTHGYGEQAEKIVAGLSRMFGGRGMNLSRLATPRSSPWNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF2</accession>
    <name>W4TIF2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68745">
        <property type="protein sequence ID" value="GAE68745"/>
        <property type="gene ID" value="JCM18909_1901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="3"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="363" mass="40312" checksum="5DC7F1F802BF27F6" modified="2014-03-19" version="1">MEFGLSREGRVALLSGTRTEWIIADMAISCAGGATTTIYEFGPEEASFILVDSHSSILFVDSTAQVAKIQGRPEVDAVVRHIISFVDDSEQTGVSDDRLTTMADVIAHGRRRLAAEPELVRRMIDSIEPDDLCTLIYTSGTTGTPKGVELTHQAWTYMGQAWKSLDVFRGGDIHLLWLPLSHAFGKCLIAICVEIGITQAIEPRIPRLARSLGEVKPRVMCGVPRIFEKIRAGVMTAYPQGRLASRVSRWAFATGRDVQQYRRAGDRLPVTVAAKLKIADALVFSTLRRKLGGIEFMICGGAKLSEQVQQWFFSRLEFLLSRGTGPPRLERLLSLVALPLFARELLGRSRRDVWRGSRRTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF5</accession>
    <name>W4TIF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinate-nucleotide adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68556">
        <property type="protein sequence ID" value="GAE68556"/>
        <property type="gene ID" value="JCM18909_1702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7994" checksum="AFA2C2E371BBB021" modified="2014-03-19" version="1">MPSVELGLARVHNGRRYRLGVMGGTFDPIHHGHLVAASEVAARFDLDEVVFVPTGVLGKRRDAGFRRPRIATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG3</accession>
    <name>W4TIG3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68566">
        <property type="protein sequence ID" value="GAE68566"/>
        <property type="gene ID" value="JCM18909_1713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22002" checksum="04F65BD7CFF78AAB" modified="2014-03-19" version="1">MASLTAIRTQGVIRRAAIELAIEKPVDDVTVDDIAERAGVSRRTVFNHFPSKYDVYLPSLVSYPQEVLDAFATDVETPLATLIRDLLEARWRAANVDFDDLCILMKIGRESSELRMAFKEAVEGQRAALVAASARRTGKSEDSLEVLALVGTVQAMERCAVQSVVARPGGSSAEVADTFDRVVDVWARLSAELSADMSSTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH4</accession>
    <name>W4TIH4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="20">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="20">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">lysS</name>
        <name evidence="23" type="ORF">JCM18909_1927</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 20 21">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="20 21">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the LPG synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="20"/>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68770">
        <property type="protein sequence ID" value="GAE68770"/>
        <property type="gene ID" value="JCM18909_1927"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 20" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="17" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="22">
        <location>
            <begin position="348"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GAE68770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="673" mass="75109" checksum="D5AEF528CAFC6388" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIS4</accession>
    <name>W4TIS4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68412">
        <property type="protein sequence ID" value="GAE68412"/>
        <property type="gene ID" value="JCM18909_1547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13108" checksum="53AB01752F5387C4" modified="2014-03-19" version="1">MSEGMTMTEQQKTGDWQERYRNALLGVFGRPQLCLDHGHGCVVVDSDGKEYLDLLAGIAVNALGYAHPAWVEAVSHQSETLAHVSNFFYHGPQLDLAEKTPRTGESTKGVGSVSLELWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV8</accession>
    <name>W4TIV8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0749 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68358">
        <property type="protein sequence ID" value="GAE68358"/>
        <property type="gene ID" value="JCM18909_1487"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010273">
        <property type="entry name" value="DUF881"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37313">
        <property type="entry name" value="PTHR37313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05949">
        <property type="entry name" value="DUF881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="275" mass="28832" checksum="F8C6BF400481FE27" modified="2014-03-19" version="1">MSDDNNPGDVRPDEASVDTGDRSQVTTDPSIQDVRSDSRHPRLARSATVIVMALAGLMMTTAAINSRGHDLRPERDTDMATLVRSQASHNAALQKEAAGLRAQVEDLSKADQTPGATSSVISSASALAPSVGLGAVSGKALRVTLDDAPLSENPDGVDANMLVVHQQDIQMVVNTLWSGGAGAMTIQGQRVISTTAVKCVGNTVVLHGVAYAPPYVIEVIGDLNAMQKALDTSEAVRIYKEYVSAYQLGWSVERAGQVTMPAYTGAVAVGHATPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIW7</accession>
    <name>W4TIW7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68731">
        <property type="protein sequence ID" value="GAE68731"/>
        <property type="gene ID" value="JCM18909_1885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5632" checksum="4F683C1ACFD6F53B" modified="2014-03-19" version="1">MTIRTRREDPEVEASQAREIGQVQAEMPVLDAEIVKPAAVLDPEPCQEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ0</accession>
    <name>W4TIZ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68388">
        <property type="protein sequence ID" value="GAE68388"/>
        <property type="gene ID" value="JCM18909_1523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13179" checksum="ECD0FC871730A618" modified="2014-03-19" version="1">MGVPSDGVEAVSLAGNEESRAFSEAITHLTTSNEKSVIDPSRSFETYSGEADARSHDAVVTLVAGSVKANSNHADDVRTALSSLDMSKLPLVNRPDTAGKTTIETGVQIVQLANVQGVPAWVPTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIZ5</accession>
    <name>W4TIZ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68129">
        <property type="protein sequence ID" value="GAE68129"/>
        <property type="gene ID" value="JCM18909_1246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="5404" checksum="36AE039EE7B8F622" modified="2014-03-19" version="1">MFFLTLIPLTVIGWANNKDLRTGRRTRRGEGRARRAAAIQSATKETMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ22</accession>
    <name>W4TJ22_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sucrose symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68537">
        <property type="protein sequence ID" value="GAE68537"/>
        <property type="gene ID" value="JCM18909_1682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="10939" checksum="1989CDC08A75D036" modified="2014-03-19" version="1">MAGVGVIPLFLVNEPWTLTIFAAMGGAAFGTYMAVDGALMVEVLPDRDDAARDLGFLNAANSLPIVFAPGIGAALVKTVGYPGLFTATIILAVLGSLCITRVTRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ82</accession>
    <name>W4TJ82_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69005">
        <property type="protein sequence ID" value="GAE69005"/>
        <property type="gene ID" value="JCM18909_2184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="35881" checksum="2DFC3845F96B6EAC" modified="2014-03-19" version="1">MPSHAEIALFEIVSSTMSHPIITGDRASHNIGITICVVTRMPDEWFRPDEEESGPGEPCPAESVEGPQESENPPSRHADSEEIPISSTTSGTIRVLTDDTGPSVVVGHARATGASASSHRRHFPIWILGVAAALVVGLVLGTFITQSRDSTGAAQVAPRAVMPASTSTADMPYQGKVKAISGVKATASCVSDPAVGSRHELVRYDAKYVVDDKPETAWRCNGSGEGQQITLTLPHPSRIVGVGMINGYAKVFGNVDLYPQYRRVRTVRWTMPDGTWFNQDFTDDDQDLQKVMIAPRTVKGDITLAIIASTQPGSLGEPTRDSVLISSVQLYEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB2</accession>
    <name>W4TJB2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dCMP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68244">
        <property type="protein sequence ID" value="GAE68244"/>
        <property type="gene ID" value="JCM18909_1367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12097" checksum="51146F61F145AC6A" modified="2014-03-19" version="1">MLVHEHRIIATGYNGAAPGRPDCLEGACPRGRLDYGEVPAFSDYDVPGSPGFCIAIHAEMNALLFATRDTVGSTAYVTDKPCSGCRKALAAAGVVRAVWSDGELGEDDLVNWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD6</accession>
    <name>W4TJD6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geranylgeranyl diphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68264">
        <property type="protein sequence ID" value="GAE68264"/>
        <property type="gene ID" value="JCM18909_1388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="168" mass="17732" checksum="654544C0F6E82903" modified="2014-03-19" version="1">MTSQMESDVVVVGAGPGGSATAAHLARRGLHVTLLEKATFPRDKVCGDGLTPRAVKQLIRLGIDVSEEAGWKHTEGLRIHGGRIAPFVLPWPELADYPNFGMVCRRTVLDERLARHAESQGVALVEGVNVTDPILDPAAAFAASGPPMAPSIPPPLSSRLMATLRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJN5</accession>
    <name>W4TJN5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NPL/P60 family secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C40.004"/>
    <dbReference type="EnsemblBacteria" id="GAE68638">
        <property type="protein sequence ID" value="GAE68638"/>
        <property type="gene ID" value="JCM18909_1788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850776" evidence="4">
        <location>
            <begin position="45"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="269"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="385" mass="40729" checksum="AE1034AADB0DDF21" modified="2014-03-19" version="1">MEHKYGASQVSGSAPRRGRGVAFAAITGAILLGTVASVDPGAQAAPDPIDQAKVRLAQLDEQTSKVQEDYTEAQAALDKAQKDLDRSQRDLKTQSDKVATMRKALGRVALSDYQSGGGVSMTTQLVASGDSGQFLSKLATIQNVTERTSVQFQDFQAEQARLKSMKSQAEADRATIESQRNQQAKLLADAKKKEQEAKQVVDRLTAQQRAELERQQAAEAQAAAAHAVSRSTGRPTDQQSALGQPSSSSTQASQTGSQVLIPDPSHGVSSRAQSALNFALAQLGKPYIWGGTGPTGYDCSGLMMVSWGKAGVSLPRTAAAQYAAGTPVSTSDLQPGDLVFFYPGITHVGMYIGDGKFIHASSPRTGIKVSVLAQQPSYQGARRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJV8</accession>
    <name>W4TJV8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69076">
        <property type="protein sequence ID" value="GAE69076"/>
        <property type="gene ID" value="JCM18909_2260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5650" checksum="E9AA81B8D0BDA39E" modified="2014-03-19" version="1">MEAVRELTDGGADKSVDALGISETLHNTVNSLRSRGTHIQIGMTAEGPVATWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK00</accession>
    <name>W4TK00_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4921 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69285">
        <property type="protein sequence ID" value="GAE69285"/>
        <property type="gene ID" value="JCM18909_2485"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032576">
        <property type="entry name" value="DUF4921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16268">
        <property type="entry name" value="DUF4921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4921" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7625" checksum="C8DA698FC91410A2" modified="2014-03-19" version="1">MAQLHRHNEHVRYVVVFQNWLKPAGASFDHLHKQVVAIDKVGADNESVLPKAVLDPGIFLIDGDPTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK76</accession>
    <name>W4TK76_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Proteasome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69206">
        <property type="protein sequence ID" value="GAE69206"/>
        <property type="gene ID" value="JCM18909_2399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11055" checksum="7A055BD5FCB05B6F" modified="2014-03-19" version="1">MPLSLSDLDGDYLMSSTTTDSFTVLLRRVAPELLPPTTVNASVPELLRHGRTVLAIRYNGGVVVAADLAPHWQDASVRPTSTVFSAPTTGALLASPGQPAWRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ9</accession>
    <name>W4TKQ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68744">
        <property type="protein sequence ID" value="GAE68744"/>
        <property type="gene ID" value="JCM18909_1900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6799" checksum="F5312AEEB158B2A2" modified="2014-03-19" version="1">MQRKLLAASAQNFAAMLDRQADAHPNRIAFMTPSGPDDEPNTWLPMTFAEFRRQAHEVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKT5</accession>
    <name>W4TKT5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4Fe-4S Wbl-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69560">
        <property type="protein sequence ID" value="GAE69560"/>
        <property type="gene ID" value="JCM18909_2789"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17615" checksum="23F023EEE0F48E4E" modified="2014-03-19" version="1">MAHWKGAIVNRMNDRTLPSCANLRAVFQHPLLEGDSTAATPDEQQLERTLQARARAACSTCPLFEQCLENAILDHDVAGFAAGTTPRQRSRIRSYLGVRVRPDDLESFAGIIGRGHQVATQDVMRLRRAHPDQPLSFIADRLGCSLSTVKRTCGGHATPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKX4</accession>
    <name>W4TKX4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69182">
        <property type="protein sequence ID" value="GAE69182"/>
        <property type="gene ID" value="JCM18909_2373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7270" checksum="DB3389AA7194B2FA" modified="2014-03-19" version="1">MTPTFIKAAHRQGRAVHVWTVNEISEARELMDMGVDGIVTDRPDLMCEFARVHQPKEAPTLIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL12</accession>
    <name>W4TL12_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="12" type="ORF">JCM18909_2322</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69133">
        <property type="protein sequence ID" value="GAE69133"/>
        <property type="gene ID" value="JCM18909_2322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE69133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="290" mass="32251" checksum="BDE630BAEB789C83" modified="2014-03-19" version="1">MGQKINPHGFRLGVTTDHKTRWYAEKQYAELVGEDVKIREWLHKNLERAGLSSIEIERRSERVTIFLYAARPGIVIGRNGAEAERVRGELEKLTGKQIQLNILEVKSPETDAQLVAQGIAEQLAARVAFRRAMRKAQQSAMNAGALGIRIKCSGRLGGAEMSRSEGYREGRVPLHTLRADIDYGFFEARTTFGRIGVKVWIYKGDVTGTRAERAAQKAARQAAQAVVVDAVETVVAGAIVLTVAVDGVAPRPPSSLLRLRPRRPRTQEPDMLIPRRVKYVSSTIQADWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL17</accession>
    <name>W4TL17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69665">
        <property type="protein sequence ID" value="GAE69665"/>
        <property type="gene ID" value="JCM18909_2910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurB_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4430" checksum="D6EE8195F983729B" modified="2014-03-19" version="1">MTNRGGASSGDLTTLARTVIDGVRDVYGITLVHEPRLIGCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL54</accession>
    <name>W4TL54_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69461">
        <property type="protein sequence ID" value="GAE69461"/>
        <property type="gene ID" value="JCM18909_2678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="218" mass="23417" checksum="68E251898EA17949" modified="2014-03-19" version="1">MRVVLVDDQKLVRQGFRLILAVEPDITVVGEATNGAEGVEVVEETAPDVVLMDVQMPVMDGVAATAKIREFSDVKVVILTTFDRDDYLFDALDAGASGFMLKNADAESLVAGLRQVADGHALLTPEVTRRVIARSVHQGSTVTGSKAEQLTAREIEVAKLAARGLSNAEIAEELVVSAATVKTHVSNCLMKCDLRDRVQLVALAYESGLIRVGELSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL60</accession>
    <name>W4TL60_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69178">
        <property type="protein sequence ID" value="GAE69178"/>
        <property type="gene ID" value="JCM18909_2369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13689" checksum="3597133B90863F04" modified="2014-03-19" version="1">MRIRGVEEIDVDVEYAPSEDPIEAMSLLTAAVVTKSELTITRCPIEFLEIELAILSEMGLDFDLSPEYVSHNGFTRLVDVTVRPSKLRAVADKIHPMPSQAQHRQPTVLCGYCCGGRRPDPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL66</accession>
    <name>W4TL66_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sorbitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69476">
        <property type="protein sequence ID" value="GAE69476"/>
        <property type="gene ID" value="JCM18909_2695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="56"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="227" mass="24297" checksum="A261D669754DD4F9" modified="2014-03-19" version="1">MIVPPQVLKVDGLNRIPDDVDFDEASAAEPFACAINAQEQLGIEKGDFLVIFGAGPIGCMHTRIARGVHKVGTIVMIDINAERLAMSAAAVKPDITIDGSQEDVVAKVMELTNGRGADVIITATPANITQEQALSMAARNGRISFFGGLPKTNPTITCDSNLIHYRQLHIHGANGSAPEHNKRALQYIASGQVPVKDLITRHVKLDDVMTVFDIVAKGEAIKVTVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLA5</accession>
    <name>W4TLA5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="11" type="ORF">JCM18909_2417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69223">
        <property type="protein sequence ID" value="GAE69223"/>
        <property type="gene ID" value="JCM18909_2417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="207"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="113"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="318" mass="33464" checksum="E816CB424CEED412" modified="2014-03-19" version="1">MRCETSFFAGTPDVAVPTLTALVADPRHEVAVVLTRPDAAVGRHRTPRPCPVAKAAKELSIPAIKATSVKSGEGHDAITSLDVDVAVVVAYGGLIPADLLAVPRHGWINLHFSLLPRWRGAAPIQRAIMAGDEETGACVFQLVESLDAGPVYRTMTVPIGPMTTAGELLDELAHTATPLVIEALEDIEAGAEPTPQSVEGVTIAPQIHPDDVRVTVTAAAQEIDNLVRGVSPAPGAWAELDGKRFKILRTRCLEAGDGVPSTVATAQPGQLVATRKQLFLGTGSQPLELLQVQAFGKRAMSGADWARGADIDAGTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLE7</accession>
    <name>W4TLE7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69263">
        <property type="protein sequence ID" value="GAE69263"/>
        <property type="gene ID" value="JCM18909_2460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020459">
        <property type="entry name" value="AMP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00154">
        <property type="entry name" value="AMPBINDING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="618" mass="68449" checksum="2CF3A61D558B8F24" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLF7</accession>
    <name>W4TLF7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69815">
        <property type="protein sequence ID" value="GAE69815"/>
        <property type="gene ID" value="JCM18909_3070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20471" checksum="945D710EA46593B5" modified="2014-03-19" version="1">MFWQNLRHLWRRRDFRKILGARVATQAADGTLQVGMASYVLLSPEQQPDAWSIAMVLAITLLPFSIIGPFISVVLDRWSRQRILVYTDGLRCLIAVGLGILVWNGARDKPSHLALLIGLLIAMSLNRFLLTALVAGLEYTIDKRDYLTASSIMPTIGPLAHDWCGCCCRSAHDCRTSYPCTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLG4</accession>
    <name>W4TLG4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate-protein phosphotransferase of PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68994">
        <property type="protein sequence ID" value="GAE68994"/>
        <property type="gene ID" value="JCM18909_2173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilizers_C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7914" checksum="0303E96DE6E0B557" modified="2014-03-19" version="1">MAFANLSAEENPALGRRGLRLSQVRTDLIDAQLEALAKAAEQTGRDPYVMAPMVATKQKPSGSPLVPMPPVSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH5</accession>
    <name>W4TLH5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69596">
        <property type="protein sequence ID" value="GAE69596"/>
        <property type="gene ID" value="JCM18909_2831"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="7226" checksum="A7524BCE717C32AE" modified="2014-03-19" version="1">MVNRVFKGILEFLVLWWFYSTLMHPTSYAFWASIVVMIMTTVTEPILDRAIERQKHAPNQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLH6</accession>
    <name>W4TLH6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Electron transfer flavoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69293">
        <property type="protein sequence ID" value="GAE69293"/>
        <property type="gene ID" value="JCM18909_2493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="17575" checksum="72E27D56A62FA0B7" modified="2014-03-19" version="1">MTLGDDKTSEWSSVQVAGALAALIQRIGGVTLVVTGDASVDEGAQLMPALVGARIGLPTFLEVTHVEPSGTGWQITQNYGGGSRVVRTDGATVIATTPDATTPKAPGMKGILKAAKKPMEDVKCSELDLSRATVNVVSRGPAPVKERKHQVFSGDGAAAQLVAALRDASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ4</accession>
    <name>W4TLJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Molybdenum transport system permease protein ModB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_2210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69029">
        <property type="protein sequence ID" value="GAE69029"/>
        <property type="gene ID" value="JCM18909_2210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="57"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="339"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE69029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="588" mass="62215" checksum="688761F4168299E8" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLN5</accession>
    <name>W4TLN5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Osmosensitive K+ channel histidine kinase KdpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69343">
        <property type="protein sequence ID" value="GAE69343"/>
        <property type="gene ID" value="JCM18909_2549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7106" checksum="FDB917B4AD31763D" modified="2014-03-19" version="1">MCWLTSCWPSWWLGRWGISVAHCGSGLGFCAGLLFFTKPFYTVTVNEPLHLVALLLYLLTAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLS3</accession>
    <name>W4TLS3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69139">
        <property type="protein sequence ID" value="GAE69139"/>
        <property type="gene ID" value="JCM18909_2328"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="35"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="17304" checksum="8D92D443CCC62322" modified="2014-03-19" version="1">MDGAIRDITAITGQKPQVTKARKSIAQFKLREGQPIGCHVTLRGDRMWEFADRLLTLALPRIRDFRGLNSNQFDGKGNYTFGLSEQVMFLEIDQDKIDRIRGMDITFVTTAQTNEEGKALLKHLGFPFKAKDDPKKAKTKRGPAYYAKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLT1</accession>
    <name>W4TLT1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69383">
        <property type="protein sequence ID" value="GAE69383"/>
        <property type="gene ID" value="JCM18909_2592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7488" checksum="A113DEC3774C2067" modified="2014-03-19" version="1">MTSLSPIWGLCSRHLRRRVEDVGSPGFGCGNPDGPVGDGDFGNLDTAGVGEHEQSHRFLCCPGIREFPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY7</accession>
    <name>W4TLY7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage infection protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69209">
        <property type="protein sequence ID" value="GAE69209"/>
        <property type="gene ID" value="JCM18909_2403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10239" checksum="FD42381DFE5ABC39" modified="2014-03-19" version="1">MLTRFIRLVQFEFRRFKGRSKLGLIFILVIPLLYGGIYLHANWDLYSNTNKVKIAVVDHDKPATFGGRTVNGGQEFQNSLKKNHVSIGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLZ6</accession>
    <name>W4TLZ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69219">
        <property type="protein sequence ID" value="GAE69219"/>
        <property type="gene ID" value="JCM18909_2413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5430" checksum="648213320823DB63" modified="2014-03-19" version="1">MNSNGNGPKTSSYQAYVWLNDDQMIQVTAQDAQTAQSTLKSALNALGVVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM25</accession>
    <name>W4TM25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_2664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69448">
        <property type="protein sequence ID" value="GAE69448"/>
        <property type="gene ID" value="JCM18909_2664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="187" mass="20471" checksum="F2771901B987D8D9" modified="2014-03-19" version="1">MAKAVQALQTKQVSRIILTRPAVEAGEKIGYLPGTLSEKIDPYLRPLYDALRDMVDPDTVPRLVGAGTVEVAPLAYMRGRTLNDAFVILDEAQNTSPQQMKMFLTRLGFGSKIVVTGDITQVDLPGGMKSGLRVVQGILDGIDDIAFCNLTSRDVVRHRLVGKIVAAYDVACESRGARNSRKNRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM29</accession>
    <name>W4TM29_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-formylglutamate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70035">
        <property type="protein sequence ID" value="GAE70035"/>
        <property type="gene ID" value="JCM18909_3315"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="PTHR32494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="137"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="297" mass="31321" checksum="9AF9E8CDD466BA59" modified="2014-03-19" version="1">MPGGGAYDGPLGVVSSLVTVAKMQEAGVMPAKPFAVVAMADEEGARFGMPCLGSRLASGKLSKAEAHTLVARDGQSLPDAWREAGLNPDLMGPDDVLLEASCFVELHVEQGRSLADVGHPVAIATAVRPHGRWCAEFTGQGNHAGTTLIPDRHDPVVPMAQTVMTAREAAEREGCVTTVGRINVEPGGTNVIASAATMWLDCRAEESQTVTKVVEDIQQASETAADKQGCQVVWTRESWTDRTAFDLRARILQILGKDIPQLSTGAGHDAATLATTMPTGMLFVRNPTGLLTAPTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM66</accession>
    <name>W4TM66_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4921 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69284">
        <property type="protein sequence ID" value="GAE69284"/>
        <property type="gene ID" value="JCM18909_2484"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032576">
        <property type="entry name" value="DUF4921"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16268">
        <property type="entry name" value="DUF4921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4921" evidence="1">
        <location>
            <begin position="2"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="162" mass="18540" checksum="0802558D61FB203F" modified="2014-03-19" version="1">MFCPDNYLSTPPEKTRLVKRAGGLVRGHDLIRCVPADRLDATVPEFRRVPNLFEILSWRYWQLNWGMSLPRAARDWQEEYLSNPSGEAHVRSVLNAKFKAVGSDRRAEDLGPQELREASAAFFAGGHDVIVARRHYTDEARQPPTLLDRRVLPSTSIGRSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMG9</accession>
    <name>W4TMG9_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetolactate synthase small subunit</fullName>
            <shortName evidence="1">AHAS</shortName>
            <shortName evidence="1">ALS</shortName>
            <ecNumber evidence="1">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69901">
        <property type="protein sequence ID" value="GAE69901"/>
        <property type="gene ID" value="JCM18909_3167"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ALS_ss_C" evidence="2">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12909" checksum="2559BAA9241FE812" modified="2014-03-19" version="1">MDAVSDQALEQIIKNLNKLIEIHKIAELEPGAVTCELILVKVRSDVENRSKIIDTVALLRAKAIDASLESLTIEATARREKLDVLLQVLEHFGIVELVQSGQVTFNRGVAVLGAKRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM1</accession>
    <name>W4TMM1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69792">
        <property type="protein sequence ID" value="GAE69792"/>
        <property type="gene ID" value="JCM18909_3047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro38C2" evidence="2">
        <location>
            <begin position="98"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19399" checksum="FE6AAE32F325443D" modified="2014-03-19" version="1">MALVNQSSYGHDVSPAGGDERTPTMGVMARLTLLRSPQSPDPHPDQGCHHLVYSLLTDARVESAHVEAARLNQPLQVRSGTVELPSTARIEPVHGTAVIDAVKQAFDGSGDLVIRIHEAEGARSRVRLLLDRDGCVSEVDLLEDPIDEPTQQLPASTCSRVELTLRPFQILTLRVSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMU6</accession>
    <name>W4TMU6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69862">
        <property type="protein sequence ID" value="GAE69862"/>
        <property type="gene ID" value="JCM18909_3124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="246" mass="26258" checksum="4467EA68ABC7CF63" modified="2014-03-19" version="1">MGEPEKKTTAARTPRAGRDLPAAITTGVVLCGAVIGTVGWWHWGFVLLMTLALMAGAIELHRAMVRLGMDSAVVPICVGTAVMVIGAYAASTLKLHILPNTFLVVTLGATTVAAMAWRLPRGSHGFVKDAAASLFTIAYLPLLGCFVPLMMGDDGGSRRIATWILSVVASDTGGYAVGVLCGKHKLAPRISPKKELGGFCRVRYNRSSRWMGLFGRTAVGAMVGWDCSWRCPSLDRHCGRPCRVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX1</accession>
    <name>W4TMX1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69887">
        <property type="protein sequence ID" value="GAE69887"/>
        <property type="gene ID" value="JCM18909_3152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6244" checksum="D196405A28F62DCC" modified="2014-03-19" version="1">MQLPLAQPDHDQAQDNDEEASATHRTHSFFTFLSLVGRFPVVLHGRALFPAVSAGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMX7</accession>
    <name>W4TMX7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium-dependent galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69544">
        <property type="protein sequence ID" value="GAE69544"/>
        <property type="gene ID" value="JCM18909_2771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="4915" checksum="7AFE89D9E142BC7D" modified="2014-03-19" version="1">MYSETPKEHLVDPQEKDLPWYRRTVPLGMTVLAITVVLNIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN23</accession>
    <name>W4TN23_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter-associated permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70375">
        <property type="protein sequence ID" value="GAE70375"/>
        <property type="gene ID" value="JCM18909_3692"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11514" checksum="75B14552CC30EB54" modified="2014-03-19" version="1">MGRSVRRDAVAIGHSDSQVFWQVALPLAVPALVAGMRVVSASTLSLVSVGALVGVPSLGYFFTDGYQRSFPTEIWVGIIGTLVLAIIFDLVIVCVGRLLTPWQRAATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN24</accession>
    <name>W4TN24_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69604">
        <property type="protein sequence ID" value="GAE69604"/>
        <property type="gene ID" value="JCM18909_2841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004703">
        <property type="entry name" value="PTS_sugar-sp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03611">
        <property type="entry name" value="EIIC-GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="183" mass="19273" checksum="CF99B6F73DE08A21" modified="2014-03-19" version="1">MVSLPALAHPFTRKITGGEDIAIGHFGTSAYIAAAATGRLVDPHGKSQSTENIKVPEGLRFLRDSMVATALSMVLMYVVVAIIFLARRGEKAAFQTFSKPATGTGNYIMASVTQGLEFGIAVAVILFLASAPSSVSSSLPSRESPARWSPAPSQHSTAPSSFPTLRMLSSSDLSRRSSEGWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN29</accession>
    <name>W4TN29_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70380">
        <property type="protein sequence ID" value="GAE70380"/>
        <property type="gene ID" value="JCM18909_3697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="24076" checksum="A0F884D3BA40C583" modified="2014-03-19" version="1">MTLTAVFFEVLLGPDDAIISDELNHASIIDGVRLCKAQRFRYRNQDMADLEAQLQAAKDCRHIMIATDGVFSMDGFVAPLPQICDLAEKYGAMVMVDDSHAVGFVGEHGAGTPEKWGVRDRVDVLTGTLGKALGGASGGYTCSHREVVEMLRQNSRPYLFSNSLAPSIAGASLAALDLLKSSSDLLTKLRENTEYFPLRDDSSWFRDPRVRSPDRARHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN97</accession>
    <name>W4TN97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70211">
        <property type="protein sequence ID" value="GAE70211"/>
        <property type="gene ID" value="JCM18909_3509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="185" mass="19735" checksum="C274D6D4069518DE" modified="2014-03-19" version="1">MVNGTAPQRYYMTDNLATQKWRLIGDSGSQVSGSWYRWFLDNGNRTDSMVVGRTMRSYCSIACSTSDGEYSELTIGGNLSQANMVRTSRAMRIESSAGLTLGQVADGTATTAQRWSHKEQVAHAVALKQWQFVAVGDGSYRIQNLATGAALGVDSTHPAHRAWGVRPQATGLVTEGPAASGSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF6</accession>
    <name>W4TNF6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70072">
        <property type="protein sequence ID" value="GAE70072"/>
        <property type="gene ID" value="JCM18909_3357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17142" checksum="E83D477C2888539C" modified="2014-03-19" version="1">MSVLLNTDLISVNIEAPDRNQVLTVMADKLNGVRVAKEGFLDALLKREEIYPTGLPISGGVAIPHTDPQYVTRDALAVTTLHTPVLFGQMGGSEEDEVPVSVVILMALSNANDHLNMLQNIVKSIQDDNLMQTIRSATKPEEVVSIVRPLIPADTEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNH1</accession>
    <name>W4TNH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70087">
        <property type="protein sequence ID" value="GAE70087"/>
        <property type="gene ID" value="JCM18909_3377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="232" mass="24108" checksum="8F17C7C4BC41B10D" modified="2014-03-19" version="1">MLSFLTAAFALGIAGFDPLGSFVLLAALGLGVRRRGVVTLLVTSVGTSAVFGIAGVLGLGALLTRLGIHGLHVPHVVWVCLVTVLGVVFVAWAAWRLRPGAPTKDFEEDTSAAPRSTAPGALAVSGLLVGLSSLIDPAFWAMLVHAAHLPHQSWAVVESLIWVACSHSLLIVLVIAYLIGGPDRVASMVTGIRESHAVAVRRGISALLAAFGILLLADVIGVVATGQWFFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK3</accession>
    <name>W4TNK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69789">
        <property type="protein sequence ID" value="GAE69789"/>
        <property type="gene ID" value="JCM18909_3041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8257" checksum="26B30F857434CFD7" modified="2014-03-19" version="1">MQVHYYGGTAEAAGTSEETLETPTGLSVNQLLDHLRSLHPGLGRLLGVCTLFVDGSAVRGEQIVPARAQVEVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNS9</accession>
    <name>W4TNS9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-amino-3-ketobutyrate coenzyme A ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70381">
        <property type="protein sequence ID" value="GAE70381"/>
        <property type="gene ID" value="JCM18909_3698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13584" checksum="83DFC801D6285BDE" modified="2014-03-19" version="1">MYGPMKDELSAKIAALKEEGLYKAEAPLTSPQSGKITVDDGREVINLCANNYLGLADSPVLIEAAKKALDEWGFGMASVRFICGTQTLHQKLERAITEFLHPDDPDNWDTILYSSCFDANGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNV1</accession>
    <name>W4TNV1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70645">
        <property type="protein sequence ID" value="GAE70645"/>
        <property type="gene ID" value="JCM18909_4009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6214" checksum="F744BA2B1FF67D71" modified="2014-03-19" version="1">MMRSLFYTTNGVLVVLIQIPISLLVERQLKNWSESPEDHDVRSVYSWHIDAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP12</accession>
    <name>W4TP12_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uronate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70153">
        <property type="protein sequence ID" value="GAE70153"/>
        <property type="gene ID" value="JCM18909_3449"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="197" mass="21960" checksum="7AE9CEB3D2D6BA4D" modified="2014-03-19" version="1">MAGRATVEEMTLLRRHLFTDQARMASEDGLTMTVHPAVYRNHDAAAFHRFGADIGSDVPVTLEVVDSLHPLLDKFGNTDLKLVVFTIDETLYSREIAPLAGWYRSLYIGVPWWFIDAPESVMRFKHAVTEMAGFSRVSGMIDDTRAFLLNSGASRYESALDAAHLAELVVLGRLDLDEAVEIAHRLVVEQPTQVFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPD9</accession>
    <name>W4TPD9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70069">
        <property type="protein sequence ID" value="GAE70069"/>
        <property type="gene ID" value="JCM18909_3354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="4">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="11801" checksum="4B5708958E211A9F" modified="2014-03-19" version="1">MGSTTSRLKDDPDAALRELLNLGCRSVVITLGSSGYIVGGPEGFDAVAAATVEAVDTVGAGDAFVGALAAELARGRTLVESCCFATAVATLTVTKPGAQASYPSADEVESIRRGEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPJ0</accession>
    <name>W4TPJ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltose/maltodextrin ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_4019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000060">
        <property type="protein sequence ID" value="GAE70651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70651">
        <property type="protein sequence ID" value="GAE70651"/>
        <property type="gene ID" value="JCM18909_4019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13378" checksum="635CF188AFC2DFF2" modified="2014-03-19" version="1">MWNLTTFFKQMPDELEQAAMIDGCSPAQAFRKIILPLAAPGIFTTAIIVFIGAWNEFLVAVTMINDPKMEPATVLLSKFTGASQFNTPFGSQMAAGVIMTVPLVIMVLVFQRRIVAGLAAGGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPJ1</accession>
    <name>W4TPJ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanine-D-alanine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70129">
        <property type="protein sequence ID" value="GAE70129"/>
        <property type="gene ID" value="JCM18909_3425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="22083" checksum="77525F0F48613F0D" modified="2014-03-19" version="1">MAAAGVVTPQQVALPHDVFRELGAQTVMRSIAEKFGLPVIVKPARGGSSLGVTKVDGVDDLPQAVANAYAYDDMVIVEEFIVGTELAIGMITTSEGTRVLPAVEIRPVGGVYDYSAMYTGGETRLTTPADISDTAAQTATAMARVVQKELDFFGISRVDAIVDESGRPVFLEAGAAPGMTATSLVPVAMKAAGLDLGEVCSRLVDDVARNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPJ4</accession>
    <name>W4TPJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70422">
        <property type="protein sequence ID" value="GAE70422"/>
        <property type="gene ID" value="JCM18909_3740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849179" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7050" checksum="0C251CE399E369E7" modified="2014-03-19" version="1">MMVVMTAPMVAILRVCFVGVLYAQALLSHKPVSHPIMGNTKHIKATFMYVKSSCVFTIDTQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPQ2</accession>
    <name>W4TPQ2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PG_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000083">
        <property type="protein sequence ID" value="GAE70716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70716">
        <property type="protein sequence ID" value="GAE70716"/>
        <property type="gene ID" value="JCM18909_4101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015020">
        <property type="entry name" value="DUF1906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08924">
        <property type="entry name" value="DUF1906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14580" checksum="0FF6F9056EF66BA3" modified="2014-03-19" version="1">MSLVCNGYSILPTSTWNSEISNTLWQFQQAHALPVTGVVDPTTWMSLLTSKGDPNRPCVACDTRFEITDELAGHLKADGYQIVGRYLSEPNQSSKSEADYFKALRTGELERIVGHGLKYFPIFQEYSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPQ6</accession>
    <name>W4TPQ6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70209">
        <property type="protein sequence ID" value="GAE70209"/>
        <property type="gene ID" value="JCM18909_3507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16903" checksum="EB748BEA6E07BB15" modified="2014-03-19" version="1">MVPSTCNTSAALYGANDVREWAFLTGNTFDDLVPDKDLNTATNPANPQDRNDDTTWRCNNSVTGKEATLAPQPTSYSQPNYCDLVGWWADSDTGDWHGLVHNEFTPRPFGDNLHYDAIDHAVSHDQGKTWTITGHVLTSPWSTTRGDTDAFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPV6</accession>
    <name>W4TPV6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrogen peroxide-inducible genes activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70408">
        <property type="protein sequence ID" value="GAE70408"/>
        <property type="gene ID" value="JCM18909_3726"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8029" checksum="DDF94E293BF114D0" modified="2014-03-19" version="1">MPRSAISAPLRADPRIVVREFTHPRPHRDIVVAGRPATMNRPAVQTLITILRQLPDDVVEPLGVAGASLCSHGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ58</accession>
    <name>W4TQ58_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two-component response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70364">
        <property type="protein sequence ID" value="GAE70364"/>
        <property type="gene ID" value="JCM18909_3680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="139"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="206" mass="21885" checksum="875907E457C5FA6F" modified="2014-03-19" version="1">MIDKTPIRLVLADDQTLVRGALAVLLGMEDDLEIVGTCGRGDEVVGLVQATDADVCLLDIEMPGLDGITVADELREQAPWCRILIVTTFGRPGYLRRAMDAGVAGFLVKDTPAEDLAQEVRKVHAGGRAIDPALAAESLIEGHNPLSDREREILRLAESGASISLIASELCLSVGTVRNHVSSAIGKTGAANRTEAAVTARHRGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ64</accession>
    <name>W4TQ64_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate regulon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000065">
        <property type="protein sequence ID" value="GAE70682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70682">
        <property type="protein sequence ID" value="GAE70682"/>
        <property type="gene ID" value="JCM18909_4058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DeoRC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11450" checksum="551933EE054AA056" modified="2014-03-19" version="1">MRMIRSMHADLCFLSASGIFEAGCYHPYQEVVEVKRAMLESAETRVLLLDHTKFGRRALFKFADLTEFDHVVVDAHTPRGVLGQLSDLGVHLMVVETSASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQD1</accession>
    <name>W4TQD1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription termination protein NusA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000057">
        <property type="protein sequence ID" value="GAE70613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70613">
        <property type="protein sequence ID" value="GAE70613"/>
        <property type="gene ID" value="JCM18909_3967"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="112"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="240" mass="27433" checksum="CDECEDB6F03A47CF" modified="2014-03-19" version="1">MDIDLSTLRMIERDKDIPLDYLLTTLEDALLNAYDKTEAPVNGAKVQLDRKTGNVAVMLPEKDEEGQVVGWYDGTPEDFGRVAASTARQVIFQRLREAEDEQKYGHFAAVEGDVITGVVQQSYRDTRTVRVDLGSLEGIMPPAEQVPGEKYSHGRRIRVYVVAVRKEARGPQVIVSRTHPNLVRKLFLLWRYLRSSRGSSRSRRWLVRPVTARRLLSSRIILTFPPRERALVRWDSGYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQP8</accession>
    <name>W4TQP8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lantibiotic biosynthesis dihydropyridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000052">
        <property type="protein sequence ID" value="GAE70554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70554">
        <property type="protein sequence ID" value="GAE70554"/>
        <property type="gene ID" value="JCM18909_3895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11700" checksum="5D365FFCBB0DB84D" modified="2014-03-19" version="1">MAARPETLAARLYANLSSVVADLWAASEPNGMFSVPALNAYTQWSRRRSSARNTSVKIDPMFLSCLANYIHTTNNRLGLPPALESTAAYLVQLGFRSVAVREEKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR17</accession>
    <name>W4TR17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000066">
        <property type="protein sequence ID" value="GAE70689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70689">
        <property type="protein sequence ID" value="GAE70689"/>
        <property type="gene ID" value="JCM18909_4066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="16841" checksum="D820EBA9B4822E5D" modified="2014-03-19" version="1">MTVTAKFPATEAAISNQANLQTWLQNQQQATDKALNNDAVTSTAYSLQRLQTMRIKIPPRVKEGSAIPVTILGTWPGGENEMTPIYTTPFSSNPTSILTDITGGKLENVRLTDRCSGAVSITPDGHDVSALHPASCSIGAEIGNYQVQETPITIVAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDT8</accession>
    <name>W4TDT8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67125">
        <property type="protein sequence ID" value="GAE67125"/>
        <property type="gene ID" value="JCM18909_165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="8">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="502" mass="52972" checksum="C7C74F683A169978" modified="2014-03-19" version="1">MEGQPRTLGLLEMLQVYLDHRLDVTLRRTKFQLNKAQDRLHLVEGLLLAIVDIDDVIAIIRSSEDAAAARTRLMGTFDLDEVQANYILDMQLRRLTKFSTIELESERDELRERIEGLTLIVNDEAELRRVVSGELAEVSSKYGTPRHTVLLGAASSVAAASAPLEVPDDPCWVLLSATGLLARIDTADGLPSGGDRATHDVIISSARTTARSDFGIITSAGRLVRVHAVELASLPITATAPSVAGGTPLADLVGLEKGERALAVTSLSGEGPSLALGTRNGIVKRVNPELLGKESWEVIGLKDGDEVVGAVEMGDEDLELCFVTQGAALLHFPASAVRPQGRSGGGVAGIKAKDPVIFFGAAPRRGSSVVTVAASSPAAAGKEPGSIKLTPLDQYPPKGRATGGMRCQRFLKGEAALVFAWIGPDPAVACAASGMPIELPAPNMRRDGSGDQGRQPILAVGSRRHGSNKDNPVSDGSNDALDSGDPLSSNEKQIDSQPELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDU8</accession>
    <name>W4TDU8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67135">
        <property type="protein sequence ID" value="GAE67135"/>
        <property type="gene ID" value="JCM18909_175"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021443">
        <property type="entry name" value="DUF3093"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11292">
        <property type="entry name" value="DUF3093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12450" checksum="96FD882F2B76B178" modified="2014-03-19" version="1">MMVNFPSGSVVYSERLWAPLSWWLIGAAVALSLIVAIGAWTSLATGGIVAVIVVVVVVAAFIKAGSVRIVVTEEGFGVGRSWIEWHWVDRVRGMDAQTMNLVMRSSHQVGSFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEH0</accession>
    <name>W4TEH0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Holliday junction resolvase YggF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67365">
        <property type="protein sequence ID" value="GAE67365"/>
        <property type="gene ID" value="JCM18909_415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8872" checksum="2D8E9CC03C3A9A16" modified="2014-03-19" version="1">MAAQDVRDAGRQLAEAINPIPVRWVDERMTTRTAARALHEAGRNARKQRGVIDQAAAVAILEHVLEQVRLGRSETATGGADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEH2</accession>
    <name>W4TEH2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67191">
        <property type="protein sequence ID" value="GAE67191"/>
        <property type="gene ID" value="JCM18909_234"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11698" checksum="152446DC379A7892" modified="2014-03-19" version="1">MRPLTHDLLARVIAVLCEEEPQCIITKVEDGIWFGELVLGDMRIDARPSDLVALALRLPVPIWCTEEVISTAGILLDAGPEDALEEFRHFLDDVSPDDFGPGPSTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEI6</accession>
    <name>W4TEI6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTP-binding and nucleic acid-binding protein YchF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67380">
        <property type="protein sequence ID" value="GAE67380"/>
        <property type="gene ID" value="JCM18909_436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="1">
        <location>
            <begin position="86"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18855" checksum="BE322B7C45E62255" modified="2014-03-19" version="1">MHDLFLLTTKPFIYVFNCDQDQLADADFQAKMEKLVAPAEAIFLDAEFEAELAEMEPEDAAEFLADAGIEEPGLDKLARVGFDTLGLQTFLTAGEKESRAWTIHKGDTAPKAAGVIHTDFQKGFIKAQVVSFGDLVEFGGEKEAQAAGKLRLEGKEYVMQDGDVVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEJ3</accession>
    <name>W4TEJ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67211">
        <property type="protein sequence ID" value="GAE67211"/>
        <property type="gene ID" value="JCM18909_255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="362" mass="39203" checksum="CAF59A6D82A301F1" modified="2014-03-19" version="1">MHATEILTAAEAQAQDIVAMAGSEAERIKEEGRRVAADMRAAAQTESDDIRVAGLANQRELRDQAAKDSRTAIEQARLQARTIVEQAGTHAEAIVTEARTKAATIDQNARAQVAQILDQARSEAATITTKARQEAENITSEARTSHDEATAKIKQLLEQATAHQQASSDNVTKRTQEADAIRQSALEEAETTRNQAARDAENRIATAHRQAAMMKERLEEQYAWRKEQLERETAALLQRKKAVIAQLNNLKALAGEAESDYPDTDPFAEEAEGETADDATIVISPKASQAQQKPAASQNTQADQSMADDKETAPLNDPASQRTQVIPAVKDRESAQPSGATAADEADNEKTQVLPQGIKPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEU3</accession>
    <name>W4TEU3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">JCM18909_82</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67047">
        <property type="protein sequence ID" value="GAE67047"/>
        <property type="gene ID" value="JCM18909_82"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="55"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="327"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="445" mass="47756" checksum="C2A116F04D04F056" modified="2014-03-19" version="1">MSRRVLLTGLTMLVGATPVPSQLLIRDERIEAMSRGRSNALDGADAEVVDLGGALVTPGMVDLHVHLREPGQEHKETIASGTAAAARGGWTTICAMPNTVPDPHSPELMADLNRRVEESAVVRVLPIAPITVGLTGNDLVDVEALTRAGAVAFSNDGKGVQLAGVMYDAMRSAAAVDRPIAAHAEDESLVRGGVINDGRRARELGLPPMTRLTETVQVARDVMIAEETGAHYHLCHASTRQSIRTLRRGREDGANVTGEAAPHHLLLADDDIPDDDGFYKMNPPLRTRDDLDAMVEGLCDGTLTCIATDNAPHAAEEKACSFRDAAFGVITNEHTFALLYTNFVLDRRFRLDQLVDWLTIGPAETFGIPEAGRLRVGGPADLAAFDLRTEMAIIPEDGAGMGRNTPFVGRSVRGDCVLTMVGGRTVYRRGQPIGKTDDHEMGDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEZ8</accession>
    <name>W4TEZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sigma-70, region 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_22</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66993">
        <property type="protein sequence ID" value="GAE66993"/>
        <property type="gene ID" value="JCM18909_22"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE66993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13780" checksum="8DC686AC9FBB39DD" modified="2014-03-19" version="1">MRYTDFIDGVGILDPAEERDLFCRLDAGAIADAILAGHFLAAVPVSEAELRRISDDGVGARQTLWRQMLAIVLTQARQAAVSYRCSVEDLIQAGCVGLGGYREVRRTSRSTVFYRCLDVDSSSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF35</accession>
    <name>W4TF35_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator of polyketide synthase expression</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_66</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67033">
        <property type="protein sequence ID" value="GAE67033"/>
        <property type="gene ID" value="JCM18909_66"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="117"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="180" mass="18958" checksum="C28AB05F4A6DBADC" modified="2014-03-19" version="1">MQMTVLAAVQSDRLVVILAGEKLVDDPAAVAASEALANHFAPGPIVVGPVVADLTLAPASARAALSGIRAARAWPEGPQVMAAVDLLPEQVLSGDTDAIAWLVNEVYSPLATASGDLMDTAVSFLDHGCSVEGTGRAMFIHPNTVRYRLKRIQDVTGYSPSDPREAYVLRLAITLGRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF68</accession>
    <name>W4TF68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arginine/ornithine antiporter ArcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67073">
        <property type="protein sequence ID" value="GAE67073"/>
        <property type="gene ID" value="JCM18909_108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018387">
        <property type="entry name" value="YcgA/YfcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF6">
        <property type="entry name" value="PTHR43652:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE67073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26822" checksum="42754B9A3BEBF8BE" modified="2014-03-19" version="1">MGYDALVVVGSIFLAGSIGTCFSTINPFSSAIGANAAGIRLTEGMTWRVIGLVGGAIAVVIYLAWYSKKVKANPEFSYAWEDRDDFAAQWSLGNDGAEIGFDWRRKVILFLFAAAFPIMVWGVMARGWWFPAMASSFLAITIIIMFIAATGPNKLSEKELVDSFSVGSSSLVAVSLIIGLARGINHILNEGLISDTLLYESAKVVSHVSGPVFVLSLLIVFFFCSASSCRHRQDWQSWPCRSWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFI5</accession>
    <name>W4TFI5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67730">
        <property type="protein sequence ID" value="GAE67730"/>
        <property type="gene ID" value="JCM18909_810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="267" mass="28752" checksum="CB2746070F6401E9" modified="2014-03-19" version="1">MACALRDAHPKVLVYDAEVTSRVLPAIAEVAPESETPTPFLIQVAPAGTSPDLPDGAVDFDTALSQADGRAPDRPSNLSTYDEVIRLYTSGTTGLPKGVPLPSFVEVMSAHDVIMHFPLTPQDRTLNMTPWFHRGGLHSGGPNPTFYVGGSVVPMREFDADTVLDWVGRYQITFLIGAPTALERLARAQEKNARDLSGLKGIVTMGSPLDAGSARRYMEVLTPNISNGYGTTETFWNTFLRPFDLPGMAGTAGRAGTDDDVEVVKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS5</accession>
    <name>W4TFS5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein Irp6C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67631">
        <property type="protein sequence ID" value="GAE67631"/>
        <property type="gene ID" value="JCM18909_704"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20683" checksum="EB967FDDC0872569" modified="2014-03-19" version="1">MIISDDDGHVSGAQLRDVVGYLPQDVLATASLTVLESVLTSARSRSKATVERAAHVLERVGIAHIAHRFISQLSGGQRQLVALAQMVVRDPQVLLLDEPTSALDLHNQIEVLRLVRRTVDSGHRMAIVALHDLNLAACYCDRLVLLHEGGVHAEGSPSEVLTPDVLERVYGFRARVLSDGGIPVVRPVVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFX1</accession>
    <name>W4TFX1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin_Reduct domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67870">
        <property type="protein sequence ID" value="GAE67870"/>
        <property type="gene ID" value="JCM18909_961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14317" checksum="74FB7F9145FADB20" modified="2014-03-19" version="1">MAILTTMGGGWARGLDGLLPASVSVVPAVVSVSLGNSSTTLAALTEESRVIVHMLDADRADLAVPGADHFADTEWVPSAEGAPRLETQGPILHGFVQSMTDTGSATLIAVTIDRIEAGNRHAPGLVRMARGWHEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFY8</accession>
    <name>W4TFY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67701">
        <property type="protein sequence ID" value="GAE67701"/>
        <property type="gene ID" value="JCM18909_779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="PTHR42706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16341" checksum="9955944AE90554C0" modified="2014-03-19" version="1">MAKKVDRESKTSFEQEVLRTVGDLDVELVVLARYMQILSPELCEQLSGRCINIHHSFLPGFKGANPYRQAHSRGVKLIGATAHFVTVDLDEGPIIEQRVQRVNHSQTVAQLTAVGQDTESATLNEAVRLFAEHRTFLDGMRTVILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG45</accession>
    <name>W4TG45_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron(III) dicitrate transport system permease protein FecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67497">
        <property type="protein sequence ID" value="GAE67497"/>
        <property type="gene ID" value="JCM18909_560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="218" mass="22174" checksum="FAB37CFCCFFB8B09" modified="2014-03-19" version="1">MVARRFRLIEGADVTVLNDQIVWQMRAPRVIGSMAVGALLAMCGAVLQTLTGNDLADPYLLGISSGASVGAVFVLIVGISSTLGQSVLMTLASFIGAVVALVMVLTMATGRSGELPAGRTILAGVAVGQLCGAAVSVMIMIFGESNAARSALSWTLGSFAGLRWGSTITLVVATVPALVVGMALCHVLDAFAFGDISAMSLGVPVNTSAGQSWSARLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG49</accession>
    <name>W4TG49_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67502">
        <property type="protein sequence ID" value="GAE67502"/>
        <property type="gene ID" value="JCM18909_565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="212"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE67502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="475" mass="51160" checksum="8AE222C9D6462F06" modified="2014-03-19" version="1">MAWAIIIYGFIAAVLPVWMLLAPRDYLSTFMKVGVIAMLAISIVIVRPVISVPAMTVYATNGAGPVFSGKLFPFLFVTIACGALSGFHATISSGTTPKLIEKESQARLIGYGGMLMESFVAIMALVAALSVDRGIYFAMNSPAGATGNTVKSAVAYVNSLGLSGVHANANTLTTTAKLVGETSIVSRTGGAPTLAVGLATIMHKIFGGEAMMSFWYHFAIMFEALFILTSVDAGTRVARFMLSDALGNFWPRLKDHSWKVGSWLTTAIMVAGWGSILLMGVTDPLGGINTLFPLFGIANQLLAAVALSICLVIFARAGHTWRLLIIFVPMLFTAIITVYGSWLKIFSPDPKLGYWANHMTYKRAIADGKASLGQAKNIDEMHTVVGNTAIQGTMSIIFVVCALIVMIVACIRTVQALRGRNIIDTEDPAKPSKIFAPSGLMPTKAERDLQVEWDAFYEKHPELDLESVHKDKEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG51</accession>
    <name>W4TG51_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67403">
        <property type="protein sequence ID" value="GAE67403"/>
        <property type="gene ID" value="JCM18909_461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21618" checksum="01C4B1B3199381DE" modified="2014-03-19" version="1">MTGPDPGHRLGGLMTRIPGTDLDIRPLVLGANTFGWTADEHDSHAILDAFLGAGGSLVDTADGYSYWADGNNGGESERIIGSWVEKGGRRDDIVIATKVATHPEFKGLAPENISAAVDASLARLHTDHIDLYYAHFDDDTQQIEDMAAAFDKLVKAGKVRWVGLSNFSVAREQKWLEVAEHEGLASGGVAAPVQLVASRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG92</accession>
    <name>W4TG92_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67811">
        <property type="protein sequence ID" value="GAE67811"/>
        <property type="gene ID" value="JCM18909_896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="212" mass="22170" checksum="4B0B14A7596C6B88" modified="2014-03-19" version="1">MLTQELAVPSVIENDARAATIGEWNCRGRHRDSCIYVKAGTGIGAGWVSGGVAYRGSRGLAGDITHLRVHTDNPLPCTCGNSGCLETVASGAAILRQLGRLGSSISTTSQLVTAENSGDPQAVSLVRDAGMRLGEVLSNLVNFLNPVRIVLGGSMSQMGSLLAGVRSELYERCLPMCTEDLVIETSACGADAPLIGMSILDSHMPISQEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG95</accession>
    <name>W4TG95_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67428">
        <property type="protein sequence ID" value="GAE67428"/>
        <property type="gene ID" value="JCM18909_488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="8675" checksum="CEA4947298522B25" modified="2014-03-19" version="1">MSGGQAQRAAVGRALAHRPAVVLADEPTGALDTTNRHAVIDLLDDLVRAEGSTLVMVTHDEHTLPGNARIIRLADGRIVGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG3</accession>
    <name>W4TGG3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67244">
        <property type="protein sequence ID" value="GAE67244"/>
        <property type="gene ID" value="JCM18909_289"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12869" checksum="D71D8DF7D5572CD4" modified="2014-03-19" version="1">MIRIQLPDTPGSLGSVATAMGTANADISAIEIVEKKGPDYVIDDFILTLPPTTMPDTLVSACGMLDGVHVLWLSRYPENWSIESDIAALNRMSEDPEHSAEILCGAVPVVFHTQWAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGH1</accession>
    <name>W4TGH1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c-type biogenesis protein CcsA/ResC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68055">
        <property type="protein sequence ID" value="GAE68055"/>
        <property type="gene ID" value="JCM18909_1164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="82"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="243" mass="25856" checksum="5A9686689D761032" modified="2014-03-19" version="1">MSVENLSAVGIVTAAVLYMLAFLAHAVEWASVRGTEHPSHEERLRSETWGRMGLNLTVLGAVCAAIGVVCRGIAAHRLPWGNMYEFVTSALFFVVIAYLVLVAIHHIRWMGIAVTLLLAVGNGLAATVFYVAVAPLVPALHSVWFVIHIVAACIAAAALNVGAIASIMYLIATNAQAKAQRTGVPVKGLVAKLPTLESMDTLAYRAHAIGFPIWTFTIAAGSVWADYAGDASGDGIPRRRGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU4</accession>
    <name>W4TGU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67369">
        <property type="protein sequence ID" value="GAE67369"/>
        <property type="gene ID" value="JCM18909_419"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="268" mass="28221" checksum="46FCEB7333444694" modified="2014-03-19" version="1">MRCAVVGHPVAHSLSPAIHRAAYQLLGLEWSYQAIDVKPGGLRAFVEGLDGSWRGLSVTMPHKADLVELGETDATVDMLGAANTWVCRDGTTIVRNTDVTGAEAALRARGVTEVEKVVVLGAGATARSVLAAAMGMGAGEVVVMSRSRERSTEILKLADGLDIRVAWLPFESEPPRCDLMVSTVPAGSLMRRAEDLAARADAVFDVVYDPWPTPLAVAGEAAGVTVIDGLDLLAGQAVGQVQLMTGYPVPMDVLRSTAQNGLAEHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH45</accession>
    <name>W4TH45_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68106">
        <property type="protein sequence ID" value="GAE68106"/>
        <property type="gene ID" value="JCM18909_1220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="26"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="223" mass="23946" checksum="33417739B4D263AD" modified="2014-03-19" version="1">MKPIHPEYVAHVLNEVADRDAIFTADTGMCNVWTARYIDPLGTRRLIGSFLHGSMANALPHAIGAQASHPGRQVISVSGDGGLSMLLGELVTARMLNLPIKVVAFNNSTLGMVKLEMLVNGLPDFGTDVHDVDYAGLAKAIGFHAERVNDPRDIRRALTDAMDFDGPALVEVITDPNALSLPPEIKGEQMIGFATAMSKIVLNRGAGEAVSMATSNMRNIPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH65</accession>
    <name>W4TH65_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67469">
        <property type="protein sequence ID" value="GAE67469"/>
        <property type="gene ID" value="JCM18909_531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5738" checksum="74DAC7AC26880AA5" modified="2014-03-19" version="1">MHGHRLDVDESTKELVQVARGLQVHAGHPTSVAMDQFEENVRKTTLRLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH78</accession>
    <name>W4TH78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68320">
        <property type="protein sequence ID" value="GAE68320"/>
        <property type="gene ID" value="JCM18909_1449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11458" checksum="E2F4D5F8C58FA8C9" modified="2014-03-19" version="1">MSTELRRVTYGNHGVARLTPAPDKPGTYMGMPKFSKAVKGELNLSVQRKNMRNATTTIRNKRAMRVSESPDWQDLRDAAESIKNRVGCHLDHYLVEAEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH88</accession>
    <name>W4TH88_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Substrate binding component of glycine/betaine transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67887">
        <property type="protein sequence ID" value="GAE67887"/>
        <property type="gene ID" value="JCM18909_979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11474" checksum="16C7E0AF0908CAFD" modified="2014-03-19" version="1">MTKTIANQTLPMYGLSNITLKTSSTPAMLAQLQKAAKAGSNVAVTLWRPHWAYDAYPVRDLDDPKNAISNAELIYSFGRPGFEKDHPSRSAHPEPRSRRRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4THB6</accession>
    <name>W4THB6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA:pyruvate transcarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67902">
        <property type="protein sequence ID" value="GAE67902"/>
        <property type="gene ID" value="JCM18909_996"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16951" checksum="C9568DCC0A772EA2" modified="2014-03-19" version="1">MQINLHCHSTTGVTLVTLQKAIEAGVDVVDTAISSMSLGPGHNPTESLVEMLEGTEYTTGLDMDRLLKIRDHFKKVRPKYKKFESKTLVNTNIFQSQIPGGMLSNMESQLEAQGAGDRMDEVMKEVPRVRKDAGYPPLVTPSSQIVGTRRCSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4THJ8</accession>
    <name>W4THJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase 2 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67982">
        <property type="protein sequence ID" value="GAE67982"/>
        <property type="gene ID" value="JCM18909_1085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="10957" checksum="11AED397B6019047" modified="2014-03-19" version="1">MTHFVVETAGPRTLIEDAGRRGWADLGISGCGAWDRRAYLDGARLVGNGAGLGCLEILLGPVRLRYVGGPVLVAVTGADARSMWMERRVLAAGDFSLQMVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4THK4</accession>
    <name>W4THK4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chorismate mutase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67654">
        <property type="protein sequence ID" value="GAE67654"/>
        <property type="gene ID" value="JCM18909_728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010951">
        <property type="entry name" value="CM_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01795">
        <property type="entry name" value="CM_mono_cladeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11361" checksum="0C767EBC33E80A7C" modified="2014-03-19" version="1">MLRGAIDNMDAALIHLLAERFRITREVGRLKAECGLPPADPTREAEQIARLRQLAVESNLDPEFAQKVITFIVAEVVRHHEAIADESGDDSGVADAGEADAPGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI14</accession>
    <name>W4TI14_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Excinuclease ABC subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68590">
        <property type="protein sequence ID" value="GAE68590"/>
        <property type="gene ID" value="JCM18909_1737"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="2">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7643" checksum="6C4FF4254B7D7508" modified="2014-03-19" version="1">MADPSSYRPAPGTIPTQPGVYRFSDEHGQVIYVGKAKNLRNRLNSYFQDISALHPRTQRMVTTAAHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI17</accession>
    <name>W4TI17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Excinuclease ABC subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68595">
        <property type="protein sequence ID" value="GAE68595"/>
        <property type="gene ID" value="JCM18909_1742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="327" mass="35002" checksum="C6CD08B7D6BE220D" modified="2014-03-19" version="1">MCCEVCHGARYNRETLEVHYKGKTIAEVLDMPIEEACTFFEPISSIHRHFQTLVEVGLGYVRLGQPATTLSGGEAQRIKLASELQKRSTGRTLYVLDEPTTGLHFEDIRKLLLVLQRLVDQGNSVFVIEHNLDVIKTADWIIDMGPEGGNGGGTVVAEGTPEQVAAVEGSYTGQYLSGILAGHEVAVGDEPALVEAPADAGKRKTTARRKAKKDHEPTQEVALRKGQALGTADSESFALLRDRGLTQTGGSRALGDVTVGYSELRSVARAQDRPVMDLVDLTASVRTHPHKSLKGSLGGWVTTKLVPSMTTPPPTGTSAALTVAGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI53</accession>
    <name>W4TI53_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67839">
        <property type="protein sequence ID" value="GAE67839"/>
        <property type="gene ID" value="JCM18909_926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6104" checksum="7D0BE93608410A24" modified="2014-03-19" version="1">MSSAPLSATELAGMIDHTLLTPEATHNDVAKLVADAKKIWDVVGVRIAIDAAVEPRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI62</accession>
    <name>W4TI62_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1344</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68222">
        <property type="protein sequence ID" value="GAE68222"/>
        <property type="gene ID" value="JCM18909_1344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="24020" checksum="CAB5F95111665DD7" modified="2014-03-19" version="1">MRRWLPSFLLVLPSIILVGVFVYGFIGKTVFASLARVKTKSGRVKAPGGWANYSQLLADGRYQHAMWNLLVLTVVFVAGTMVFGLLWALLLEKGVTGEGFFRSIFLFPMAVSFVAAGVIWRWLLSPAKDGQATGLNQLFLFIWECPGYSHPGIRRGSSIWRLWPSRLSGSCPAISWLSSWPVSAVFPKTSVRQLGSTVRPRSSSTGTFSSRSSRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI63</accession>
    <name>W4TI63_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68446">
        <property type="protein sequence ID" value="GAE68446"/>
        <property type="gene ID" value="JCM18909_1584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019551">
        <property type="term" value="P:glutamate catabolic process to 2-oxoglutarate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007780">
        <property type="entry name" value="NAD_Glu_DH_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43403">
        <property type="entry name" value="PTHR43403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="292" mass="31346" checksum="5893F593CF02293E" modified="2014-03-19" version="1">MSSLLSLTDNVVEGKVVAPEGVVRHDGDDPYLVVAADKGTATFSDTANAIAAEHHFWLGDAFASGGSHGYDRKAMGITARGAWESVTRHLADLGIDQATEDFTCVGIGDMSGDVFGNGMLLSRHIKLVAAFNHRHVFVDPNPDPETSWQERRRLFNLPRSSWGDYDSSLISEGGGVWNRTLKSIPVSLHMHEALGIDASVNRMTPDDLISAILRAPVDLLWNGGIGTYVRATSETDAQVGDRANDPVRVTAKEVRAKLPVKVETSVGPRLAVSSMPAMVAALTPTSSTTQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIC8</accession>
    <name>W4TIC8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68715">
        <property type="protein sequence ID" value="GAE68715"/>
        <property type="gene ID" value="JCM18909_1868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5756" checksum="8BDC4CAC8F58BCCD" modified="2014-03-19" version="1">MLLIVVIARIRRELLRSFAILRELLGGLVISRLTTIRIGLLGGQFGVIVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIH5</accession>
    <name>W4TIH5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68581">
        <property type="protein sequence ID" value="GAE68581"/>
        <property type="gene ID" value="JCM18909_1728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10585" checksum="F8478A667CD19635" modified="2014-03-19" version="1">MWGSGGTWVTLYDVISAPLMTWPVLTMSIILCVLSVILTLFVLLHKSKGGGLSDLFGGGVSTSMGGTSMAERNLDRLTIVMGLLWLASIIVLLVLYSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIV5</accession>
    <name>W4TIV5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-asparagine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68452">
        <property type="protein sequence ID" value="GAE68452"/>
        <property type="gene ID" value="JCM18909_1590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="414" mass="44910" checksum="BAB33590615A6CC3" modified="2014-03-19" version="1">MIAFLVMRALGELVIHRPSSGSFVSYARELLGDRWAYAVGWMYMLNWMTSGIAELTAIGTYLQFWWPSLPMWVPSLVALMILVSVNLISVKAFGEFEFWAALLKVVALTAFIIVAIGLVASHVNVGGHRAAVSNLWRFDGGFAPQGVLPLILVIQGVIFAYATIELVGTASGETQNPRKVIPKAVHAVVFRLVVFYLGSLALLAMLLPYKEYSADESPFVTAFSAMGVGWIGDAMNIVVITAAFSSVNSGLYATGRVLKSLAAAGEAPKFAGTLNRFKTPSGGILMTASVFLLGVGLEYVVPERAFEISINTAAVGVIWTWATIFWCQLVLRRQVNEGRITDSGFHMPGYPITGIFGIVSLAGVTALMVLDPQNRIVLAASLVYIAVMLVAWPAVKRNKARHPELNAQEDITFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIW6</accession>
    <name>W4TIW6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-proline glycine betaine ABC transport system permease protein ProW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68094">
        <property type="protein sequence ID" value="GAE68094"/>
        <property type="gene ID" value="JCM18909_1208"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848779" evidence="3">
        <location>
            <begin position="32"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="4">
        <location>
            <begin position="72"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="339" mass="36708" checksum="AD03E6DE443ACF82" modified="2014-03-19" version="1">MSRSMVRRKVIAVASALTVGALSLSGCGATNSGNGESGGSDAGSDNVNTKWADCTPGRGSKDTTSMKADSKKDITIGAFNGWDESFATAGIMKNVLEKDRYKVTIKGFDAGPGYAGLVAGDIDLLTDGWLPVTHADYVKRYGDKMENLGCWYDNAKLTIAVNKDSKARTIGDLKAMGDEYDNTLYGIEAGAGLTKATKDSAIPKYGLKNLNFKISSTPAMLAQLKKSTSAGQDIAVTLWRPHWAYGAFPVRDLKDPKKAMGNAEVIYSFGRPGFEQDFPKVAQLVRNMAFDDNKLSDLEDTMFSADKYGGKNQEKAVEEWISRNNDWVDKLKTGQLAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJB5</accession>
    <name>W4TJB5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MTS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68876">
        <property type="protein sequence ID" value="GAE68876"/>
        <property type="gene ID" value="JCM18909_2046"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="74"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="244" mass="25789" checksum="694556440061AED4" modified="2014-03-19" version="1">MPLQALTEAGIVSIAGSTARALVDVRPYGSPDDGASGWTVSDLTPGLDKAITKIRPDYVLGVSPASVSLTQMAVPTHVGSVLDMGCGCGVQSLHLSRHADHVVATDVNPRALEMAQLTCRLSHADVDIWDGSLYDPCGHDTFDLIVTNPPYVMAPPSRDGQRLIYREGGFCGDGLVEAVVRGAPARLNDGGMLQVLANWAHIGDQPWPERLATWVEETGCDLWVSSASASTFASTSRPGLPMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC7</accession>
    <name>W4TJC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68513">
        <property type="protein sequence ID" value="GAE68513"/>
        <property type="gene ID" value="JCM18909_1656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="12963" checksum="079CDB7D276C6149" modified="2014-03-19" version="1">MTELTRLDLSGLNRKLSGVELTVACDVTSPLLGPEGAAAVFGPQKGLDHEGIAVAEAGLTRLADLMEPAIGSTYRDDPGSGAAGGVGWALRCLGAKYRPGAAAVLGWAKAVSKNLWGRTCCHGRGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJC9</accession>
    <name>W4TJC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68259">
        <property type="protein sequence ID" value="GAE68259"/>
        <property type="gene ID" value="JCM18909_1383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046264">
        <property type="entry name" value="DUF6297"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19814">
        <property type="entry name" value="DUF6297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="14418" checksum="6943404425B6B854" modified="2014-03-19" version="1">MKAVEAVAGLAGLAVLLGVISTASGWYAVPMSSGTNLVSAWVVAGAGAVLLVVTFVLARLRLNRIRRARLMAGGTLASGMQGAAFALDFALIRDILQEREAIERGQVRPTRGRSEGLRAWCGATCSVSCGPQSRCSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJD8</accession>
    <name>W4TJD8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69065">
        <property type="protein sequence ID" value="GAE69065"/>
        <property type="gene ID" value="JCM18909_2248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4111" checksum="BC6D51E4E9D20F7D" modified="2014-03-19" version="1">MTAGSSIVAGSVLSRECAAPATVSDITSDSQDDTLNPEADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJF2</accession>
    <name>W4TJF2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68279">
        <property type="protein sequence ID" value="GAE68279"/>
        <property type="gene ID" value="JCM18909_1403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="8092" checksum="56D26C2DA3D2B328" modified="2014-03-19" version="1">MWLIIVKVVILFVILLAWTIFNVWFERRVLAKMQNRIGPIMNSAWAGGVFQAVGDGLKLIFKEMLTPKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJH3</accession>
    <name>W4TJH3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="7">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mraY</name>
        <name evidence="8" type="ORF">JCM18909_1843</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68692">
        <property type="protein sequence ID" value="GAE68692"/>
        <property type="gene ID" value="JCM18909_1843"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE68692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="336" mass="36501" checksum="2CC02C6F36ECDA01" modified="2014-03-19" version="1">MFIHWLAAKGYGQFIRDDGPTTHKTKKGHPDHGWRCHYCLRTAGVPRGTPGDMDHPSISALLVLWLFSGLGFIGFLDDWTKISKQRSLGLKPKGKLLGQAFVAITFSIGVMYFPDVHGVTPGSPAISFLRDISWLYLPVWLGIVWVILLIAGSSNAVNLTDGLDGLATGASTMVFGAYTVLSIWQFNQWCSRPTTAGNHCYAVRDPHDIAVIAIAIAGACFGFLWWNAKPAQIFLGDTGSLALGGAVAGMAVVSRTELLLVIIGALFVIETVSVMLQVSVFKITGGKRVFKMAPLHHHFELKGWAEVTVVIRFWIICGLAVSTGLGIFYAEWVAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL3</accession>
    <name>W4TJL3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transport ATP-binding protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_1760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68613">
        <property type="protein sequence ID" value="GAE68613"/>
        <property type="gene ID" value="JCM18909_1760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="13"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="269" mass="28376" checksum="81B503682BA59680" modified="2014-03-19" version="1">MAQGSGSCFALATGDVLASLTRDVDRIEVVYAHTFAPVVAAIVAPLVAVVTGGVLYGWFVAAIPAVILVVLIVALLVIGTRASLDATHEMLGVRRELAAHITDSVFGAAEIVGYGRQSDRTMQMARLDADIAAGSAKARRYAAMRRASCVAATLGIVAWVSVVGVSGGVDGVGVCVLVVAGLRVVEGLRGVEDAVGYLDHSLAAARRLWCLSYSPVEVVDGPEELCLDQAPALEWRGVSFFVIVTRMVCRCLRCLRMSLWVFRLGGMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJL5</accession>
    <name>W4TJL5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-binding membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68732">
        <property type="protein sequence ID" value="GAE68732"/>
        <property type="gene ID" value="JCM18909_1886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="54"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18632" checksum="629649A7DDC4F42A" modified="2014-03-19" version="1">MRRRRVDLAERIDLLTRAVDLSQGRIPDDVVVQARAVVERADQRCRIGGDHTVIALAGATGSGKSSTFNALAGAELTDPGVRRPTTSKATAAVWGTESAEALLDWLNVPRRHHMGSGDTLDGLVLLDLPDHDSVCIEHRLEVDRLVEMVDMIVWVVDPQKNTPMPPCTPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJX1</accession>
    <name>W4TJX1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68409">
        <property type="protein sequence ID" value="GAE68409"/>
        <property type="gene ID" value="JCM18909_1544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="146" mass="15458" checksum="4FEE835D29D12C50" modified="2014-03-19" version="1">MVSIRDRRIHVGHYPLGFRAGGIQAGLRITPGLDLALIVNDGPADVVAGVFTTNRVCAAPVQWSRHVTADHKARAVIANAAVANACTGIDASPTVSARLSMLRPFSSASRTRSLSPHLESSESGRYAVHSGGSEHCPPRPRQGRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK11</accession>
    <name>W4TK11_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ORF">JCM18909_2325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69136">
        <property type="protein sequence ID" value="GAE69136"/>
        <property type="gene ID" value="JCM18909_2325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10420" checksum="6A4F46AE49B25E23" modified="2014-03-19" version="1">MSENTAERTTRRKVREGLVVSDKMNKTITVLVEDRVKHPLYGKVMTKSVRLKAHDENNEAGMGDRVRIMETRPLSATKRWRLVEIVEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK25</accession>
    <name>W4TK25_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68882">
        <property type="protein sequence ID" value="GAE68882"/>
        <property type="gene ID" value="JCM18909_2053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025338">
        <property type="entry name" value="DUF4244"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14029">
        <property type="entry name" value="DUF4244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10214" checksum="B9EA9AC821CD8F48" modified="2014-03-19" version="1">MSENTDPTMDPVISARSLDLVGATDVVEPRHRGRYRAARNKIIDRGMATAEYAVGMLAAVALALVLLKIVTHQEVFTKLLKLVVSIIGKAGGMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK36</accession>
    <name>W4TK36_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Preprotein translocase secY subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69161">
        <property type="protein sequence ID" value="GAE69161"/>
        <property type="gene ID" value="JCM18909_2351"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="264" mass="29235" checksum="BD168F0BAFC8FDD2" modified="2014-03-19" version="1">MGELITDRGIGNGMSIMIFTQIAARFPDSLWSIKVARNGAGQAHAWFIFGMVIAIGLAVMAAVVFIEQGQRRIPVQYAKRMVGRRMFGGSTTYIPLKVNQSGVIPVIFASSILYLPVLYATFRPQTSAAKWIGHYFTRGDHPAYNIAYFLLIIFFCYFYVAITFDPVEMSDNMKKYGGFIPGIRAGKPTEDYLAYVLSRLTAPGSLYLGLISMIPTLAFVSLHANQNFPFGGTSILIIVGVALDTVKQVESKLQQRHYEGFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK40</accession>
    <name>W4TK40_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69166">
        <property type="protein sequence ID" value="GAE69166"/>
        <property type="gene ID" value="JCM18909_2357"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="208" mass="23042" checksum="9ABAEAED7AB981B0" modified="2014-03-19" version="1">MLGTPWKHVPEPRSNPSSTDSGYYPRTKAGASSDSQTLSIVLRNDEGAPRRTPSRPEQSVERTRKGCHMARLIGVDLPRDKRLEVALTYIYGIGRTRATETLKATGISGDLRVHELTDDQLVALRDHIEANYHVEGDLRREVAADIRRKIEIGTYQAVVTAADSRFVVSAPAPTPVPARVRGRPSPRRRPSESSPKGTHQPSPTRRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK50</accession>
    <name>W4TK50_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69176">
        <property type="protein sequence ID" value="GAE69176"/>
        <property type="gene ID" value="JCM18909_2367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6790" checksum="7C2CD748BE733F6C" modified="2014-03-19" version="1">MDNITPASVGRLIRDARKQHGMTQNQLAEILKTSQSAIHRWNQARRTSLWSTSTASRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKC9</accession>
    <name>W4TKC9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69400">
        <property type="protein sequence ID" value="GAE69400"/>
        <property type="gene ID" value="JCM18909_2609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12708" checksum="651ABB60251FCDA5" modified="2014-03-19" version="1">MTVRNSVGQQAQSIYSDDHGITWHAGNPVGRMMDENKVVELSDGTFMLNSRDAARSGRRKVAYSHDGGLTWGPVKLVDDLIDPTNNAQIIRAYPNARAGSAEAGSCYSRMPAMPRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF8</accession>
    <name>W4TKF8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68644">
        <property type="protein sequence ID" value="GAE68644"/>
        <property type="gene ID" value="JCM18909_1794"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PTHR21337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01358">
        <property type="entry name" value="DAHP_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="401" mass="44247" checksum="522476815DDB89C7" modified="2014-03-19" version="1">MLQGGDCAETFAGVNADNIKSKLRVLLSMAVVMTYAGQLPVVKVGRIAGQYAKPRSKDTETRRGLTLPSYRGDAVNGFEFTPEAREHDPKRLIGVYNASAATLNLVRAFATGGFADLRGIHAWNADFVRNSNVEARYEALAAEIERALVFMMACGVEGDQLSTVDFYASHEALLIDYEHAMTRIDSRSQLPYDCSGHLLWIGERTRQIDGAHVEFLRHVRNPLGVKLGPTTTGEDAVAIADALDPDHEPGRLTFITRMGSKAVRTNLPRVIEAVEATGRKVVWSCDPMHGNTFETNNGYKTRSFADMCDEVNGFFDVHEELGTWPGGVHIELTGDDVTECLGGVDKLAESDLTNRYETVCDPRLNRNQSLELAFIIAERLADGRIKRDAVSPLARFRNIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKG1</accession>
    <name>W4TKG1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69286">
        <property type="protein sequence ID" value="GAE69286"/>
        <property type="gene ID" value="JCM18909_2486"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8212" checksum="590EB9D8468D2BAE" modified="2014-03-19" version="1">MTVGFGHRYPSVEVWSTSRVDQPGGLTMRESTPFQISCMPRTWPSATMCLPMRSGITARWVRECRFRGGSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKN3</accession>
    <name>W4TKN3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68719">
        <property type="protein sequence ID" value="GAE68719"/>
        <property type="gene ID" value="JCM18909_1872"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="AA_permease" evidence="6">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22115" checksum="99334CF34E54086E" modified="2014-03-19" version="1">MESQPDRFLPLRANVRLIGFTAAAGIMNFVVLTSAASSANSGVYSTSRMLYGLAHKSMAPRAFGKLSRHGVPGWGLFCTIILIGSALILAAKDSVMGAFTLVTTVSAVLFIFVWSMILISHIVYVRRNPQAHAKSIYPMPGASFMPWVVLAFFVFVIVLLTGADDTLQALLATPIWFVVLGIVWAIVRRHSHHDDLETDLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKU5</accession>
    <name>W4TKU5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69048">
        <property type="protein sequence ID" value="GAE69048"/>
        <property type="gene ID" value="JCM18909_2230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11592" checksum="2BBBA105207C73AD" modified="2014-03-19" version="1">MNFDNMPELHWKFGYLYCILSMVASSGILYVIFRKKQLVITRSDTGSRYRPVLGRMAYPDTEYAKTTRSSGRVAFSSPASAKHKQQRWTSESPASLYDNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKV6</accession>
    <name>W4TKV6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="9" type="ORF">JCM18909_2352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69162">
        <property type="protein sequence ID" value="GAE69162"/>
        <property type="gene ID" value="JCM18909_2352"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20911" checksum="F702E5B27AEF467F" modified="2014-03-19" version="1">MRLLIMGAPGAGKGTQATAIAEHYRVPAISTGDMFRINIKNGTELGKKVKAIMDAGDLVPDELTDAIVVDRLNQDDAANGFLLDGYPRNMHQVEALDAYLKEHGQRLDAVISLDVDPELLTQRLLKRAEIEGRTDDNEETIRNRMKVYSSQTEPLLEHYRSAGILVPVDGVGEIDEVRQRIFAALDSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKY8</accession>
    <name>W4TKY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69103">
        <property type="protein sequence ID" value="GAE69103"/>
        <property type="gene ID" value="JCM18909_2290"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="25582" checksum="CEEC51E5B76E5A66" modified="2014-03-19" version="1">MAMAFVLSGCGAVIGTTLKVNDDGSGSRSLTVTFTNDDSDEAKQVFAKPLSVYDASIKKHVPSQLTYNGLHMQGKSMVASFQLDFSSPQDYLTKVRAIIGGSKDPTSDIQNINTPLVNGVVGKENFTSRDLLEWLPQGLEQDGIVDSGNVGNVLDSENNMTLTIGGKNFTSQTPLDVEHVADNGFDQVVVQLNFKSMKTSVPSSGTSPSKPGALTKKIRSKPSSTRPPKMAMVRPPTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKZ3</accession>
    <name>W4TKZ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000026">
        <property type="protein sequence ID" value="GAE69635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69635">
        <property type="protein sequence ID" value="GAE69635"/>
        <property type="gene ID" value="JCM18909_2875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13000" checksum="03A0BA8C5ABE69A5" modified="2014-03-19" version="1">MTVSWQGVTKTFPSGDSARGGCTIHCADATVDAGQACLIKGASGQGKSTMMAMIGGLLPVTSGHITIAHGHGDRDPEQARREGLVAYAFQYPFLTPYFTVWENAALCAEARSRISCWLLRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL11</accession>
    <name>W4TL11_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S-adenosylmethionine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2421</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69227">
        <property type="protein sequence ID" value="GAE69227"/>
        <property type="gene ID" value="JCM18909_2421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="8">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9529" checksum="2ABF7F7CCD98ADAF" modified="2014-03-19" version="1">MPGAYAIGAARPVGFRIDTFGTNHVPEAVIERAVGEVFDLRPGAIIADLDLLRPIYSQLVAGGHFGRELPGVTWELTDRTEALAATARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL50</accession>
    <name>W4TL50_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_2359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69168">
        <property type="protein sequence ID" value="GAE69168"/>
        <property type="gene ID" value="JCM18909_2359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE69168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="220" mass="23965" checksum="4AE1DEDA8B27E00E" modified="2014-03-19" version="1">MLIAQRPTLTEESISEFRSKFVIEPLEPGFGYTIGNSLRRTLLSSIPGASVTSIKIEGVQHEFSTIEGCVEDVTEIILNLKGLVLSSEEDEPVAMYLRKSGAGEITAADINPPAGVTIHNPELHIATLNDDGRFEMELIVERGRGYVSSALNDDPNAEIGRIAVDSIYSPVLKVTYKVEATRVEQRTDFDKLVVDVETKPSILLATPLPPLARPSLSCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL75</accession>
    <name>W4TL75_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="3">DERA</shortName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="3">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoC</name>
        <name evidence="5" type="ORF">JCM18909_2385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69193">
        <property type="protein sequence ID" value="GAE69193"/>
        <property type="gene ID" value="JCM18909_2385"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="250" mass="26427" checksum="F10FE2BA665CED61" modified="2014-03-19" version="1">MSIAALIDHTLLAPDATAQHIRTLCREAVDHGFATVCVSPTRVRLAADELAEHAPRVCSVIGFPSGAHLSEIKAAETKAAVNDGADEIDMVINVGAVKDGDWDTVESDISAVVDAAGMAIVKVILEVSELTDEEITRACQAAEWCGAGFVKTSTGFSRHGATAEAVSLMRRTVGDRLGVKASGGIRTPNDVATMLRLVPPASVPPPGSPSLLTRRHCDHQRHHCPQRHGRGSWHPQHVVGPHQGPHLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL97</accession>
    <name>W4TL97_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69516">
        <property type="protein sequence ID" value="GAE69516"/>
        <property type="gene ID" value="JCM18909_2741"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848804" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6016" checksum="838669BFD75DE948" modified="2014-03-19" version="1">MIALTILSKAALLAVNPIVVAPSASSGCISQPVTCSPGPIYQDHKELVGSFCDLQTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLI3</accession>
    <name>W4TLI3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69840">
        <property type="protein sequence ID" value="GAE69840"/>
        <property type="gene ID" value="JCM18909_3097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022395">
        <property type="entry name" value="CHP03773_ABC_transptr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022435">
        <property type="entry name" value="Surface-anchored_actinobac"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03773">
        <property type="entry name" value="anch_rpt_wall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03769">
        <property type="entry name" value="P_ac_wall_RPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="292" mass="30956" checksum="ED069115DFCA6748" modified="2014-03-19" version="1">MAGWETFDVKRNGFSEVTINVRNVKGPGKVHLFSQSSFGNVQTLLDGGSHTMPGTITVKKPSHVHANWVFTQPGLYQMTVDATAVRNGTTVSTGAHTYTWAVGSKAIAAATSCSTDRVAGSPARSNTGTPTPKKDSTRGSSDKPFDDLGVIHNTLENDSASSNGSTRVTRSGSSIKKEICHPVKIPNKADAVKKTVARSAGKSTAIATEGHFDWGVQLQSGKLISSLKDDRSAPAKWVDPSSIVMAVGDKANTTAPAGMEFIAKGGTKVWLIGATQVRRAVARRQYDARVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ9</accession>
    <name>W4TLJ9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Di-/tripeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69313">
        <property type="protein sequence ID" value="GAE69313"/>
        <property type="gene ID" value="JCM18909_2514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005279">
        <property type="entry name" value="Dipep/tripep_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="PTHR11654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00924">
        <property type="entry name" value="yjdL_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="432" mass="47143" checksum="415BC31B85AE3899" modified="2014-03-19" version="1">MSLEPLDVDAEGVAAATKARGFRPKHLVTGPSRDDKSFLGHPGGLPWMLQVEMWERFSWYGMRAILVYFITDTLAHGGLGLPINAGQVVMASYGAAVLLMTIPGGIFADRILGPWMSTLCGGLIIMTGHVILAIPQVVTSWIGLICIAIGTGFIKPNLSTVVGGLYDDGDPRRDQGFLYFYMSISIGSLFAPIVTGLLKDHYGYHVGFIAAAIGMALGLIAFFHGRSKLREFAFDIPNPLAPGEGRRMVLRALGIAVIGAVLAIGFKALLGEWTSAIAYALFAFASVTALGYFLTMFRSPKVSDRERGHLWAFVPLWVGQVLFTMIFEQAAGKMATFAKDNTDGHIVGSWSVEPEQYQTINGRSLDPGRPARHVVPAQGREVPQYPAEVRHFGVHHRYNRPHHGIRFPELARWEQTRTVVVPGGGVRHSDCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW1</accession>
    <name>W4TLW1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69502">
        <property type="protein sequence ID" value="GAE69502"/>
        <property type="gene ID" value="JCM18909_2723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="83" mass="8986" checksum="BF1735C78E25B084" modified="2014-03-19" version="1">MWACWGTSGTGWLGVYEFNHIAGYNFGGGSSGGPWLDEYSNTTGLGYVRSVTSNGPTDSTAYIQGPYFDSRVNDLFVAANNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLW9</accession>
    <name>W4TLW9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69189">
        <property type="protein sequence ID" value="GAE69189"/>
        <property type="gene ID" value="JCM18909_2380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010743">
        <property type="entry name" value="Methionine_synth_MetW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07021">
        <property type="entry name" value="MetW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="37" mass="3878" checksum="54A5E451AD412DE6" modified="2014-03-19" version="1">MMPRPGIVASLVPSSQVLGLGCGDGLLLRHLITTRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM31</accession>
    <name>W4TM31_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69453">
        <property type="protein sequence ID" value="GAE69453"/>
        <property type="gene ID" value="JCM18909_2669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6405" checksum="87E767959649A063" modified="2014-03-19" version="1">MVHRWTWAATHGVLTPVIADLCERMAHRAVQDWGMVQTSGRCKLFFSHAKLRNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM40</accession>
    <name>W4TM40_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69597">
        <property type="protein sequence ID" value="GAE69597"/>
        <property type="gene ID" value="JCM18909_2832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6557" checksum="BCECE16D35476DD0" modified="2014-03-19" version="1">MIPVLFVLVFQECYLDSPWTWETVVLGGLVLFALGMGVSLLMGMLARVVAPPDSSCGQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMB5</accession>
    <name>W4TMB5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome (Plasmid) partitioning protein ParB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70125">
        <property type="protein sequence ID" value="GAE70125"/>
        <property type="gene ID" value="JCM18909_3421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="46" mass="5507" checksum="C5040317DA803287" modified="2014-03-19" version="1">MKLGEQLSQRFRTAVKVRRRNGRGTITFPFNDNEELERLIDILSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI7</accession>
    <name>W4TMI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xanthine/uracil/thiamine/ascorbate permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69757">
        <property type="protein sequence ID" value="GAE69757"/>
        <property type="gene ID" value="JCM18909_3008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="503" mass="52754" checksum="D334DD9CB894D806" modified="2014-03-19" version="1">MPSNTASARFDQWFHLTERGSTTSREVRGGIVTFFTMAYILALNPLIIGTAADKNGKLLNGAPKFLDAAGTSLNTAGIDDNKIMVMAVTAFVAAIMTIAMGVWGRFPMGIATGLGINSLLAYVVAPTMTWSQAMGLVVWEGIFILVFVLTGVREMIFRAVPNSLRSAISVGIGLFIAFVGFVDSGVIRPGSGTPVTLGVGGSLEGWPILLCLFGFLLLVVLHQRHIKGSMLIAIIGTSLVGVAIEALGNIGAQSVKNPTGWALNVPRLPGVSDFRWPDLGLLGHVDLFGGFLANGHFRIGVFLGTLLVVFSLMLADFFDTMGTVVAIGDHAGILDETGNPEHLKGILVVDALAAVAGGLGSASSATGYVESAAGVGEGARTGIASIVTGLGFLLAMFLSPIVSIIPSEAAAPVLVFVGFLMMAQVTHIDWKHVEEGLPAFLGMVLMPFAYSITTGIGAGLIMFCITKVIAGKARSVHLLLWVVALLFVVYFSQSLLMKLFGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TML0</accession>
    <name>W4TML0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose operon transcriptional repressor MalR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69409">
        <property type="protein sequence ID" value="GAE69409"/>
        <property type="gene ID" value="JCM18909_2619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="41"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="148" mass="15409" checksum="C0DD91AF7A60BD0E" modified="2014-03-19" version="1">MSTYHELVDVGLPLVLVNGYSPSITVPQISDDDVSAMDQAVAHLVGLGHTHLGLAIGPRRYVPVQRKEQGLRAAVDRHLEGRGRVTVSNTVFSVDGEARAAVDLLGQGVNAIICGSDLMALGAIRAARAQGLSVPDDVSVIGCDDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMN5</accession>
    <name>W4TMN5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">JCM18909_3247</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69971">
        <property type="protein sequence ID" value="GAE69971"/>
        <property type="gene ID" value="JCM18909_3247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8602" checksum="B784B80A7B272B35" modified="2014-03-19" version="1">MKQGIHPDYRETTVVCTCGNTFTTRSTSQSGTLNADVCSKCHPFYTGKQKILDAGGRVARFERRYGKKRTDVVYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMP6</accession>
    <name>W4TMP6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69449">
        <property type="protein sequence ID" value="GAE69449"/>
        <property type="gene ID" value="JCM18909_2665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15550" checksum="6D42CD7960595FFF" modified="2014-03-19" version="1">MTLVGPNDEFLKRLEDALDADILVRGNEIHLAGHPADLADAGDILSEMITIIRTGQGLSADDVDRVVAMTRNGEDPAEIMTADILSNRGRTVRPKTLNQKNGMLTRLTPTPSPLVSAQLARARRIWRWPRRCRRFRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMQ5</accession>
    <name>W4TMQ5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-keto-3-deoxygluconate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69703">
        <property type="protein sequence ID" value="GAE69703"/>
        <property type="gene ID" value="JCM18909_2952"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10443" checksum="53A027AB93252647" modified="2014-03-19" version="1">MTYDISTIGEGQIRLTCYKGERLINAQQLRATAACSEANVSGLLSQLGRSTCWASVMPKGDLTDRIVNEFRSVGVDVSHICMKPEARRVVFHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMR4</accession>
    <name>W4TMR4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69832">
        <property type="protein sequence ID" value="GAE69832"/>
        <property type="gene ID" value="JCM18909_3088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19923" checksum="E15E04C88D3518E7" modified="2014-03-19" version="1">MTRPRGVPPCDGPAQVGKVEVCPLVEEDLEWLWHWNVEVVDPQWKQWDGPYFGPDDDRSFAEFAEEWRSGLMSGHRAVVTVDGHRAGFISRFEEPPAGGGWWEVGIVVFRPTLWGRGVGRRALRLWTEATFATTDAQVVTLTTWSGNGRMIHCAGAVGYRECGRIPQARSCRGVAGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ7</accession>
    <name>W4TMZ7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-deoxy-glucuronate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69569">
        <property type="protein sequence ID" value="GAE69569"/>
        <property type="gene ID" value="JCM18909_2802"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8238" checksum="DF722D6D6C44D770" modified="2014-03-19" version="1">MISNGDVALVPHGWHGPCAAAPGYDLYYLNVMAGPGTAEWKSVDDPHYWWIRQTWQDQDIDPRLPLAVDDSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN14</accession>
    <name>W4TN14_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69594">
        <property type="protein sequence ID" value="GAE69594"/>
        <property type="gene ID" value="JCM18909_2829"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="296" mass="32091" checksum="9DF15F0438C46561" modified="2014-03-19" version="1">MARAGFARENQDGIDVDDPHRTFVDDWPKPEILVALSDFEGLCGFRDPHETRQLFDELEVLTPTDPVLGSLTERSGSAALAETFLNCLAGDDVRRQIVTEVVSGAVNHVGEDTPLGEFARTTVELDEYFPGDPSILAALMLNRVHLKPGQALSVPPGLMHSYLSGTGIEIMADSNNVVRGGLTNKHIDIDSLIQIVSFQTQEPRIIAAEEVDPGMRVFPGIDDQFRLWQLDLDTTCPAMMPASELARILLITDGYAVCSGPHGTDEIVRGQAVWIPAGERVQIDGDCDGFIAAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN61</accession>
    <name>W4TN61_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP synthase alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69957">
        <property type="protein sequence ID" value="GAE69957"/>
        <property type="gene ID" value="JCM18909_3230"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab" evidence="3">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="4">
        <location>
            <begin position="164"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="332" mass="36285" checksum="3C60BCD4F422C257" modified="2014-03-19" version="1">MKGALEKAGAMEYTTIVHAPASDPAGFKYIAPYAGSAIGQHWMYQGKHVLIIFDDLTKQAEAYRAMSLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDDLGGGSMTGLPIIETKANDVSAFIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGAAQIKAMKSVAGTLKISLAQYRDMQAFAMFASDLDDTSRRQLDRGARLMELLKQGQFSPYPVEEQVISVWGGTTGKFDDVPVGDVLRFEGDVLEHLRSHSNVLTTIRETGKFDDEAKDAAAAAFEEVKKGFKTSDGKMLAGHEEFSPMADETSTKPRSFARRRLSRGVEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA8</accession>
    <name>W4TNA8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiJ/PfpI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70012">
        <property type="protein sequence ID" value="GAE70012"/>
        <property type="gene ID" value="JCM18909_3291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="114" mass="11950" checksum="8ED6798E8CEA00B8" modified="2014-03-19" version="1">MAARALIAVTDFGVEEAELVEPLNALTKAGIEVTVASNSGESIQTVTGDKDWASKVNADSSLPTPRLPITTCSSSPVAPSMRIPCVLTRTDVAWSRSSQLLASRSGLSVTDRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG8</accession>
    <name>W4TNG8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="12" type="ORF">JCM18909_3594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70286">
        <property type="protein sequence ID" value="GAE70286"/>
        <property type="gene ID" value="JCM18909_3594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="11">
        <location>
            <begin position="8"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="10">
        <location>
            <begin position="85"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE70286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="168" mass="18312" checksum="CE6EF390FC06458A" modified="2014-03-19" version="1">MPESEDTVWLTQEAFDKLTQELEYLKGEGRTAIANKIADARSEGDLSENGGYHAAREEQGQAEARIRQLEQMLRNAEVGEAPSSPDEVVPGSKVTVCYFDDESDTDTFLLGSRQVMGLDDSVNVSVYSPQSPLGGAILGHSKGESTEYQAPNGKTIKVTILNVEPFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNJ1</accession>
    <name>W4TNJ1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="2">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69779">
        <property type="protein sequence ID" value="GAE69779"/>
        <property type="gene ID" value="JCM18909_3031"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1 2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoeA_N" evidence="4">
        <location>
            <begin position="38"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="MoeA_C" evidence="5">
        <location>
            <begin position="366"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="438" mass="45782" checksum="ECA66CA72F7E17CE" modified="2014-03-19" version="1">MMLWRCSTGKKQVEAPEPEAEPLGLPGAPETDMSGRRSVDDHRDYLCSLVQAVPPVAVEVPRAVGLAACEDVHAPHDVPVVTTAVIDGYALDSASTRMAGRPGAVEIQVDRRPPSPVIPGTAVRVMAGSLLPEGTDCVLPPDLLNADGDIVLFSPVKRWAGARLAGSDYGRGEVLVRNGTILHPGIISVLASAGIDEVFVRPRPKVVIVAVRADEDQRAEIERKARANGADDIASLDATAAAIESATRALDVNVTVVSTNTSSDSELTRLLANAGRGADLVIATSDRIVVGQQDPVSSVLPPMGGTDFARVAMEPGANQVFALIDPGLVPLIVLPVGPGPALVSFMAFVRPLLRKLSGLPPAEKLKAETDRPIARHPESTTFVPVRLARVGGRPVLSRAGMGDVTHVVDLSMADAIAVVGAGDEPVPTGMPLTCWRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNK7</accession>
    <name>W4TNK7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000051">
        <property type="protein sequence ID" value="GAE70545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70545">
        <property type="protein sequence ID" value="GAE70545"/>
        <property type="gene ID" value="JCM18909_3886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045773">
        <property type="entry name" value="DUF6226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19736">
        <property type="entry name" value="DUF6226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="217" mass="23218" checksum="6FF04068B8303255" modified="2014-03-19" version="1">MTTIADVRIGVDRVFDALGAPSWPNPHADHSVAAEEEYSRVTDPERYRVLMLRLQAWQTVLAKLCDVDVDTMAKGRGRLQQRCSSPHSDTLPLYVSVVTFDQVPFVGLSATSDADPFDIIPDCACDACDHGSEDLLRVLDADLAAVVDGSLVVVTGPVVDDESTFHLVGAGRGCASTWGGDEIGPLAEPEAVIDAIRSGDDPLLPPGCTVLHGRPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT7</accession>
    <name>W4TNT7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribose ABC transport system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70063">
        <property type="protein sequence ID" value="GAE70063"/>
        <property type="gene ID" value="JCM18909_3348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12987" checksum="B91E753C138C63B6" modified="2014-03-19" version="1">MRVQARAALERIGLNVSPDRLVGSLSTAHQQLVEIARALSMDARVLILDEPTAALTRKESGQLFEVMDDLKTKGVAMVFISHHLDEIPRVGDDVSVLRDGTLVGRYRPVPRNVSWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP00</accession>
    <name>W4TP00_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70431">
        <property type="protein sequence ID" value="GAE70431"/>
        <property type="gene ID" value="JCM18909_3749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8689" checksum="554BDD63022C5EB2" modified="2014-03-19" version="1">MKALLLENIHDEAVRTLKKKAGYEVERVSEALDEDDLISALDGVDLLGIRSRTRVTRRVVEACGDNLYAVGAFLYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP22</accession>
    <name>W4TP22_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ORF">JCM18909_3203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69934">
        <property type="protein sequence ID" value="GAE69934"/>
        <property type="gene ID" value="JCM18909_3203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="207"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE69934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="325" mass="35887" checksum="116B32B2D4EF59DB" modified="2014-03-19" version="1">MTDVRADHGSLLWSCERHEPSRYVVVVTHATRDDAFDAAAEFISEMAGRDIGCAVPGDQVKPMSSKLPGVDLESLGEFAHEAEVVVVFGGDGTILRAAEWSLPRHVPMIGVNLGHVGFLAELERSDMADLVNKVCSRDYTVEDRLVLKTTVTEHSGQHRWSSFAVNELSLEKAARRRMLDVLASVDELRVQRWSCDGILVSTPTGSTAYAFSAGGPVMWPDLDAMLMVPLSAHALFARPLVMSPAARVDLDIQPDGSESAVLWCDGRRSCTVRPGERITVVRHPDRLRIARLAAQPFTSRLVKKFELPVSGWRQGRDRHHLEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP42</accession>
    <name>W4TP42_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70481">
        <property type="protein sequence ID" value="GAE70481"/>
        <property type="gene ID" value="JCM18909_3808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20b" evidence="2">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19213" checksum="0574DA4E03D12A54" modified="2014-03-19" version="1">MPTNDTLIRGLCPQPRQVQLTEGRFPLPSVLTWTGPDEVINAVTILTERLAPALDVVRATSHTDDVSLTVIVDPALEAEGYRIDIDAQVRITAGSPSGARWAVQTLLQLLTPWVYGPGPLALKHLCLPKGVIVDAPHHSWRGAHLDVSRHFMPTSFIMSFFGRAGRTQAQSAAPASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP54</accession>
    <name>W4TP54_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MutT/Nudix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70496">
        <property type="protein sequence ID" value="GAE70496"/>
        <property type="gene ID" value="JCM18909_3823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="115" mass="13084" checksum="57F4775588117927" modified="2014-03-19" version="1">MNLWIQPGGHVEHTENPWQALAHELHEETGYSIDQLSVLQPWDRLPDGIHDLMHPTPVLLNTHSPYRAISTPTSSWRWSPMAIRRENRAQGSLKSCSGSVLTNLPRCRRPSLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP57</accession>
    <name>W4TP57_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70193">
        <property type="protein sequence ID" value="GAE70193"/>
        <property type="gene ID" value="JCM18909_3491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7123" checksum="5826967ECED29DFE" modified="2014-03-19" version="1">MAPQSVCDALAEAIDHGSETVLNGVPASRLNLPNGVVWCWWLPAPPNCSTILPVRTSCLIARRLSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP80</accession>
    <name>W4TP80_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000050">
        <property type="protein sequence ID" value="GAE70521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70521">
        <property type="protein sequence ID" value="GAE70521"/>
        <property type="gene ID" value="JCM18909_3854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="105"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Condensation" evidence="5">
        <location>
            <begin position="194"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="356" mass="40020" checksum="0E9A42F81BFBBE72" modified="2014-03-19" version="1">MVLRETTHQFLRQGDASLAAFYLPRADCLVTPKMLNNRAKSSLPRVMCPSRWIKVTDIPTTSNGKVDIKLLERRAGELLLNEIQESREGSIPGRVEQNRDSFILLVQDVLGTPVNPELTFIESGGDSLRAIQLANIVRSRGSYVRVRDLLSSYTLGSLAKEYQAQQISPKKSTSAKKDLLPALMTSKIPLTCDMNPAQQGIYFQWLLEPESPYYNYQILLECAGPNTDRIRRALGQALRANPQLMAKFGVDSTGRFTQTFPISAIDMDEISIHEVASAQEAREICWMKAAVPFNLEEGPAIAVDEIRINGYSTWFVLTMNEILIDGWGAMKFMEQLISLFLSVVTWTIRKSKSRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPP1</accession>
    <name>W4TPP1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-proline glycine betaine binding ABC transporter protein ProX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70378">
        <property type="protein sequence ID" value="GAE70378"/>
        <property type="gene ID" value="JCM18909_3695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14354" checksum="E4496932FD3B337B" modified="2014-03-19" version="1">MGGNPELKERPYGPKGLTKAYGVPSSIVKFNTLSDSSGPLTVKALTSGTVDLVDLYTTTPAIKEQHLVVLSDPRHLIVPQNVVPLLSKKVDDKARAQLARVSKALTTDDLIGMNQRFQGDEKKPPQPPSPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ28</accession>
    <name>W4TQ28_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000059">
        <property type="protein sequence ID" value="GAE70642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70642">
        <property type="protein sequence ID" value="GAE70642"/>
        <property type="gene ID" value="JCM18909_4002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7728" checksum="A244AEA062507FD2" modified="2014-03-19" version="1">MVSVEADVGQVLEHGRPDVRPAGRGAKVSRCALARAQTAEGKLAKSDLGRARLIDQNRAYRAQLRHDFWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQE6</accession>
    <name>W4TQE6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70449">
        <property type="protein sequence ID" value="GAE70449"/>
        <property type="gene ID" value="JCM18909_3775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="154" mass="15814" checksum="C32C0C65CEA5922D" modified="2014-03-19" version="1">MVGILGGTGAAMMQTINNDPQATKSARIVGGDLQTGVILLIIFAFATVACSVGVNQASAILDRRSVEVGLDVVGMDLQAQDKVRRITVISPMRFAMVTGVIATGLLLVPATGIALITRPATVLVMVATIVAGACMVRWVCGLPDRLCAGSSTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQF1</accession>
    <name>W4TQF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000047">
        <property type="protein sequence ID" value="GAE70454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70454">
        <property type="protein sequence ID" value="GAE70454"/>
        <property type="gene ID" value="JCM18909_3781"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="181" mass="20022" checksum="0F20094CDCDAD8C8" modified="2014-03-19" version="1">MTVLDRSEDMLSVLESSAEEKDVEIDVVHQEWPADLGCQFDSVIAAWSLYWNLDLQASLQAMVRQTKKHLIIIDTTGSPTVWDHALAVARGGGVVASQARHLLFAGGLAQLGIPAEIRLLEEYRVVGETELEREIDAHGGSKVAAMEFLDTHAVKIRSGWRYRRTVGLIHAQGKNIPARNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQU5</accession>
    <name>W4TQU5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoyl synthase</fullName>
            <ecNumber evidence="6">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lip-syn</fullName>
            <shortName evidence="6">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lipA</name>
        <name evidence="9" type="ORF">JCM18909_3960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="6"/>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70609">
        <property type="protein sequence ID" value="GAE70609"/>
        <property type="gene ID" value="JCM18909_3960"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="65"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE70609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="328" mass="37126" checksum="C7E99167B03A02BC" modified="2014-03-19" version="1">MSKQTVGNSSESRSRILRRPSRTNPTGSRLGPQCPEYRDMRRRMIDGDLHTVCQEAGCPNIFECWEDREATFLIGGDHCTRRCDFCQIESAKPEGYDKDEPRRVAESVKQMGLRYATVTSVCRDDLEDEGAWLCAETIRQIHKVTPGVGVEMLAQDFSGKQDLLDIVFETRPEVFGHNLETVPRIFKRIRPGFRYDRSLAVLDSAHEAGLITKSNLILGIGETREEISQAMRALHDANTDLLTITQYLRPNSYLHPIDRWVTPQEFDELAEEAREIGFVGVMSGPLVRSSYRAGRLYRQAMEARGERPVTIVTGYRDGAKPAPFAAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDI8</accession>
    <name>W4TDI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_40</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67010">
        <property type="protein sequence ID" value="GAE67010"/>
        <property type="gene ID" value="JCM18909_40"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="4610" checksum="4C61BC09DCAC5C0D" modified="2014-03-19" version="1">MLETVGHPYIVSGAHPVLRDRGFAIIGNHDESAVGRKVRALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEJ8</accession>
    <name>W4TEJ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain protein EC-YbbN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67216">
        <property type="protein sequence ID" value="GAE67216"/>
        <property type="gene ID" value="JCM18909_261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="174" mass="19065" checksum="6906806451056C49" modified="2014-03-19" version="1">MVGRAEPVMVEVSSEEPVGPDPRTVEAEKLMDAGKFDEAVAAYDALLASEPNDPVLIAGRNGAALLGRLDGKDPTALLTAAQQHPDDVDAQLAAADVELMGGRPADAFNRIIQVVRATHDEERETARTRLLDLFLRWSDNLPPRLPQLAVLWQPCCSEVRMAWCARELEDRDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TER4</accession>
    <name>W4TER4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-phospho-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67286">
        <property type="protein sequence ID" value="GAE67286"/>
        <property type="gene ID" value="JCM18909_332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8273" checksum="E647663F6694EFCF" modified="2014-03-19" version="1">MEQAELAVREGVDIEAYFVWGIIDIVSAGSCEMEKRYGVVYVDADNEGRGTYKRLPKDSFYWYRDFIASHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEU9</accession>
    <name>W4TEU9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Twin-arginine translocation protein TatB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67480">
        <property type="protein sequence ID" value="GAE67480"/>
        <property type="gene ID" value="JCM18909_542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="15079" checksum="823061D0E61D0E00" modified="2014-03-19" version="1">MSTAGPAEIAVLIVIAVLMFGPDKLPEMARKAARVYHYLKNIANNTRDQLRSELGPQFADLDYQDLKPQNFVRKYVLDSLQDDIDEIKADLSDVRSDLDLGLADIRNSEGLPETPASAPSSVVHDEAVPVPFDLEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEY8</accession>
    <name>W4TEY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67356">
        <property type="protein sequence ID" value="GAE67356"/>
        <property type="gene ID" value="JCM18909_406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14338" checksum="B747FC474622032A" modified="2014-03-19" version="1">MAYAYDFVVNGNEVGGGSIRIHRRDVQERVFNVMGIGPEEAQEKFGFLLDAFKFGAPPHGGIAFGLDRLVMLLGGFETIRDVIAFPKTGNGYDPLTAAPAPITPAQRREAGVDAKPKKPSSGQTSNVEADKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF43</accession>
    <name>W4TF43_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_78</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67043">
        <property type="protein sequence ID" value="GAE67043"/>
        <property type="gene ID" value="JCM18909_78"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17310" checksum="0E9477D238633065" modified="2014-03-19" version="1">MTSSHRALLVVDVQPTFCEGGALAVTGGNACAERIATYIPTHHNCYDMVVTTQDWHIDPGNHFSNNPDFVDSWPPHGVVGTDESEIHPAIAKIRVDARVKKGQYAAAYSGFEGTTEDGSTLETVLRDRGIKLSTSSAWLCPTVSKTRLWTPSISGSSRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFA0</accession>
    <name>W4TFA0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67645">
        <property type="protein sequence ID" value="GAE67645"/>
        <property type="gene ID" value="JCM18909_719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17608" checksum="483B4FD9F298857F" modified="2014-03-19" version="1">MVMIATVLPDEPQPVLAHNQPDWRRLVEVLTMGFVGSVMVALWGWGSPQGGVPTHVRPIGVAVAVSGIAGLIAIIIAWLRSRKLVGRRVLTSVVWSLPLLFGPPLLSQDGWAYAAQGWILTQGMDPYRVPQGLAEVLGKAVDTPWQATTAVYPPGSLWIQAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFG5</accession>
    <name>W4TFG5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methionine aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67506">
        <property type="protein sequence ID" value="GAE67506"/>
        <property type="gene ID" value="JCM18909_569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13473" checksum="5BCAC7D328B94263" modified="2014-03-19" version="1">MNRAIKAVKPGRSISIIGRIIENYAKRFGHGVVRDYTGHGVHSAFHSGLVVFHYDEPRYDVTLEEGMTLTVEPMLTLGDQSNHQWDDGWTVLTNDGSRCAQFEQTLVVEKDGARILTTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFL0</accession>
    <name>W4TFL0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67317">
        <property type="protein sequence ID" value="GAE67317"/>
        <property type="gene ID" value="JCM18909_364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007139">
        <property type="entry name" value="DUF349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03993">
        <property type="entry name" value="DUF349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10896" checksum="89BF35C2E159C548" modified="2014-03-19" version="1">MNRWKAAGPAPRDVDDKLWKEFRAIQDTFFDARTAAQSQQDEEYRGNQEVKEQLLDEAEKDILPVKDIEEAKVKLRAFLEKNSMRLVEFLVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFR2</accession>
    <name>W4TFR2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein YceG like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67367">
        <property type="protein sequence ID" value="GAE67367"/>
        <property type="gene ID" value="JCM18909_417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="89" mass="10069" checksum="3D741028C97F572E" modified="2014-03-19" version="1">MPHRRLHLGTRGQKKPKDMQMIAGIIYNRLQQGMKLESDATVLYANHVEGKLTTNDEQRAKDSPYNTYLYNGLPPTPIDNPGATSMEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFS8</accession>
    <name>W4TFS8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67825">
        <property type="protein sequence ID" value="GAE67825"/>
        <property type="gene ID" value="JCM18909_911"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5940" checksum="D1F9FFA57F6692DA" modified="2014-03-19" version="1">MSHPCYLESGEHCCSWTGEVFARMFVALPHMSGRVWSPRRPILAMITTFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFU4</accession>
    <name>W4TFU4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ornithine carbamoyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67397">
        <property type="protein sequence ID" value="GAE67397"/>
        <property type="gene ID" value="JCM18909_454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14072" checksum="5EC80324FC23EEC8" modified="2014-03-19" version="1">MAFNLKNRHLLSLAHHSTEEIKFLVGLAADLKEAKYCGTEQPLLKGKNIALIFEKASTRTRCAFEVAAHDQGAHVTYLGPSGSHIGHKESMKDTARVLGRMYDGIEYRGFHQSVVEELAEYAGVPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG77</accession>
    <name>W4TG77_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67796">
        <property type="protein sequence ID" value="GAE67796"/>
        <property type="gene ID" value="JCM18909_881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5320" checksum="60431DAE32B41989" modified="2014-03-19" version="1">MGRIAAGLYLTAAVAAAAALLIAWWQSIHMQTFIQATNLMTWTHPRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG78</accession>
    <name>W4TG78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67955">
        <property type="protein sequence ID" value="GAE67955"/>
        <property type="gene ID" value="JCM18909_1057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="157" mass="16864" checksum="AB2EDFF9F7CD4455" modified="2014-03-19" version="1">MGSEQAAAVESAAGKAIRDKVKEDGGPIPKEAAAIRFRPNLYTREVVLHVSSVRTGPTGTVLTFWVTSQDSDDAVMFHNLPENFPSIIDAAGGVKYGVNYFNKPLYPREVVGSQEPQIDATSVYVMQASYPPLPKSVTKVKIAVGSAKTSPDISVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG98</accession>
    <name>W4TG98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67557">
        <property type="protein sequence ID" value="GAE67557"/>
        <property type="gene ID" value="JCM18909_624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="255" mass="27108" checksum="1328761FCB621FDB" modified="2014-03-19" version="1">MTITDTYTEELAIDLTGSALPPAQKGMDVQRIDGEDGSLLVEFSATSSGCLFELVGKNGRLSVDVDADRLLGRIDLNGETRSLDAEDALGMADGTIHSVGLTADETGTHLFADGYETFSATLRAWCQDLRATNIVINPSGVLDVQRFRMWNSALSLQAMAAKAPAATPFVEFAGSELSARDARRTGELAHGALRARTAFVAKPRVEPSSQPKGAPVNCPSRSSTATCSCTWKWTMNPSPTCALQASGTTETGMTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGC7</accession>
    <name>W4TGC7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67463">
        <property type="protein sequence ID" value="GAE67463"/>
        <property type="gene ID" value="JCM18909_525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="166" mass="17654" checksum="70FA2532D32AA5F7" modified="2014-03-19" version="1">MMVGILGFLLIIVILGKWSELRRIRVSPAIVGGGLAIGTSLALYVSATLMTTIANAVFLIYTGPLFATILARIFLKERVGLRNGIFFMLVFTGMLLTVGLVQLGGGSVVSFGLQFGAVEGLPRKPLGDLFGLGSGVFLWSGTIFSIATEVTFPQKYEDSGISFSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG8</accession>
    <name>W4TGG8_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67249">
        <property type="protein sequence ID" value="GAE67249"/>
        <property type="gene ID" value="JCM18909_294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017519">
        <property type="entry name" value="CHP03085"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03085">
        <property type="entry name" value="TIGR03085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23112" checksum="E900964FC82169B7" modified="2014-03-19" version="1">MSIAQDERAGLAADLSRLGPDAPTLCKGWTARDLLTHLLLRENDPLAVPGMAVNVFDAVTQARADRLKASGSFEDLVARFAHGPGRFSVFRIPGLDSAANSMEYFIRHEDLLRAQPDWRPRELGHRAELRLADIIRKYGRALARRSPVGVRVEMTGQTDPVTLHPGDRIVTLVGKPSEVILLLTGRTSVAQVDVLGEPATIAAFMRSDRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGP3</accession>
    <name>W4TGP3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="9" type="ORF">JCM18909_665</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67593">
        <property type="protein sequence ID" value="GAE67593"/>
        <property type="gene ID" value="JCM18909_665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18615" checksum="57EADAFD9ADE9CD0" modified="2014-03-19" version="1">MTDTPTENLENTEVTPFTEGDREIAYRTDSNPTVAAGDSKRPAMIAPGAATGRRKEAIARVRIIPGSGQWKINGRTLEDYFPNKVHQQIVTEPFTTAGVEGAYDVIARIGGGGVTGQAGALRLGIARALNNVDAEASRPALKKAGMLTRDARVKERKKAGLKKARKAPQYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGS4</accession>
    <name>W4TGS4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7,8-dihydroneopterin aldolase</fullName>
            <ecNumber evidence="1">4.1.2.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67961">
        <property type="protein sequence ID" value="GAE67961"/>
        <property type="gene ID" value="JCM18909_1063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="PTHR42844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FolB" evidence="2">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12946" checksum="10243CFC74979E0E" modified="2014-03-19" version="1">MTYGQITLTGIRAHANHGVLASERELGQPFSVDVSLDVDMDTVSDDLTQAVNYATVAQRVLNILTREPVSLIETLAGKIADTVLAISPRVHFVQVTVHKPHAPVGVALDDVAVTYRKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGU5</accession>
    <name>W4TGU5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67986">
        <property type="protein sequence ID" value="GAE67986"/>
        <property type="gene ID" value="JCM18909_1089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013549">
        <property type="entry name" value="DUF1731"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010099">
        <property type="entry name" value="SDR39U1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08338">
        <property type="entry name" value="DUF1731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01777">
        <property type="entry name" value="yfcH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1731" evidence="3">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="299" mass="32450" checksum="673415EF066876AF" modified="2014-03-19" version="1">MRIAIGGFAGLIGTALVQRLRKEGHDVVTLTRHEPIQPSDRRWDLDTLSIAPPFLDDVDAVVNLAGAPIADGRWTDERKTRILASRIDSTRLVVRALASSPRCRIFLNGSAVGYYGPHGDEWLDENDPAGAGFLAEVCQRWETAANSAPDGVRVATLRTGHVVSSFGGMLGKERPFFQFGLGGKIRDGSQYMSWISLHDHVSAMMKILTDDAMSGPVNLVSPNPCTNAEFTTALAQAMHRPSVIPFPVPAAKMIFGSQLVDEALCSGQRVKPAKLLEHEFGFRDTSITESITSALAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH34</accession>
    <name>W4TH34_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two-component system response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67842">
        <property type="protein sequence ID" value="GAE67842"/>
        <property type="gene ID" value="JCM18909_930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7303" checksum="8EBCE72AE0F7C07B" modified="2014-03-19" version="1">MALPTQPPRFTRADGSPIRVLVVEDEPSLTGLLSMAMRYEDGTSPPLIPVLMPSTKHRPPALTSSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH53</accession>
    <name>W4TH53_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">NAD(P) transhydrogenase subunit beta</fullName>
            <ecNumber evidence="6 15">7.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nicotinamide nucleotide transhydrogenase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">JCM18909_515</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15">The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the PNT beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67454">
        <property type="protein sequence ID" value="GAE67454"/>
        <property type="gene ID" value="JCM18909_515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:NAD(P)+ transhydrogenase (AB-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012136">
        <property type="entry name" value="NADH_DH_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000204">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="10 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="17">
        <location>
            <begin position="19"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GAE67454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="469" mass="49241" checksum="AC17DD3C464B9039" modified="2014-03-19" version="1">MTSTLLIAPLAGSLVNFVNASFIVAGLLFIFALAGLSRFETSKKGNAYGILGMVIAIVATIVALVKLPGYSPVSIVLLFIPMLIGGAFGVWKAVKVEMTGMPELIAQLHSFVGLAAVLIGFNAFAEEGTGASTFQLSEIWIGIFIGALTFTGSLVAWGKLSGKVASKPLTLPGRNWINLGLLVVILACGIWFSNVSGGIAWLPLALLTLASLFLGFHLVAAIGGADMPVVISMLNSYSGWAAAFSGFSLHIPVLIVTGALVGFSGAILSYIMCKAMNRSFVSVILGGFGDAPAVEGEGPAGEITEIKADELASQLSEASSVIIAPGYGMAVAQAQYPVAELAKKLRDEGVDVKFAIHPVAGRLPGHMNVLLAEAHVPYDIVMEMDEINDDFADADVVLVIGANDTVNPAAMDPGTPISGMPVLHVWEGHEVVVFKRSMKLDMPVWRTRCSSPITPGCSSVMRRQALTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH68</accession>
    <name>W4TH68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68131">
        <property type="protein sequence ID" value="GAE68131"/>
        <property type="gene ID" value="JCM18909_1248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17161" checksum="A8298CF59DC49440" modified="2014-03-19" version="1">MNSHRWYTPWLLVAPAVVWTVVFALYPFINTIILSFTNTRPLVGGEFIGFANYAELWHDDMFWNAMVTTFIYVIICIPLLTILPLLLALLVEKKIPGISFFRTVAYFPVIASVVVVASSGAGCSILAASLTSPCNGWALPAAPSLSSSIAGSCSAARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH69</accession>
    <name>W4TH69_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycogen synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67474">
        <property type="protein sequence ID" value="GAE67474"/>
        <property type="gene ID" value="JCM18909_536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="199"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="400" mass="43249" checksum="063B39A24E237E60" modified="2014-03-19" version="1">MWDDQAMYVSVLTREYPPTIYGGAGVHVAQLVPQLRALIDVDVQCMGQPREGATAHAENYPEGANGALRAFGADLSMVDAIPDEVDLVHSHTWYANLAGLLAGVFHDVPHVISAHSLEPDRPWKAEQLSGGYRLSSWAEKTAYDAADAVIAVSEGMRADVLRAYPELDPDKVQVVRNGVNTDEFHPVTETDVCRDIGMDPDRPSVVFVGRITRQKGLVHLVHAATELDPETQLVLLAGAPDTPQIGEEFKAAFEEVRSSRRAPVIWVPEMLPRSSVRQVLSAATVFACPSVYEPLGIVNLEAMACATPVVASRVGGIPEVVVDGSTGHLVDGVPTDLSTPEDVAAFESAFAAAINDLTRNIERAKAFGTAGRQRCIDEFSWPRIAAQTVEVYQTAIKRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH93</accession>
    <name>W4TH93_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ORF">JCM18909_1275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA-binding protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68156">
        <property type="protein sequence ID" value="GAE68156"/>
        <property type="gene ID" value="JCM18909_1275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10243" checksum="DE648CF49BB168FD" modified="2014-03-19" version="1">MLADALEHLVSGIVANPDDVRVREKDLRRGRMLEVRVNPSDIGKVIGRQGRTASSLRTVIGALAGDEQIRIDFVDVDRRGSGRHSDHRGHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THA4</accession>
    <name>W4THA4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MlrC_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67813">
        <property type="protein sequence ID" value="GAE67813"/>
        <property type="gene ID" value="JCM18909_898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010799">
        <property type="entry name" value="MlrC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07171">
        <property type="entry name" value="MlrC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlrC_C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6817" checksum="7BC487663707E141" modified="2014-03-19" version="1">MVKIGYLEPDLYDLAADWIMALTPGGVDQDLIRLGHNRLRRPIFPFDEDMQDPDLTVTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4THF8</accession>
    <name>W4THF8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Solute-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68226">
        <property type="protein sequence ID" value="GAE68226"/>
        <property type="gene ID" value="JCM18909_1349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11541" checksum="C852A7CC630A9564" modified="2014-03-19" version="1">MSTDPQAVSILISKGGLWPASTTGLANKALQKPDAFYSNDKVFVPFIDVAKNLKYDWVWGPTQVQAGQDMENNLVKVSKSYPITKALADTQESTLAKLKKQGIKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM2</accession>
    <name>W4THM2_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="1">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydroxymethylbilane = H2O + uroporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="1"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68012">
        <property type="protein sequence ID" value="GAE68012"/>
        <property type="gene ID" value="JCM18909_1118"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="PTHR38042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEM4" evidence="2">
        <location>
            <begin position="23"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="241" mass="25074" checksum="2883B1F5C97CD1E0" modified="2014-03-19" version="1">MTTNPADLVKPPVVVPRDDSHDKFVTTLKQAGYGVIHTALTRTVTLPDAEGLTTPDLWHADWLVVTSKTTVGLLPTPLPNPNIKVAAVGAATSAALRTRGIDVDFVPGDHSGAGLVAEWPGGAASILLPTSQLAADTVPLGLTKIGCTVNRLEVYTTATVEKLPEVIAQSWPSVGVVIVTASSVGRALVELVEPLGWRHQKLVALGKPTARTLEELGHPAHAVASSPTPEAVLEAVESLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4THM6</accession>
    <name>W4THM6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68301">
        <property type="protein sequence ID" value="GAE68301"/>
        <property type="gene ID" value="JCM18909_1429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19709" checksum="FE1B5B872173F844" modified="2014-03-19" version="1">MPQRKVSVINHYAFPPGSGGITRNFDMFSRLRDWQPHFYAANINHTSGERMTVDDPRYTLVPIPEYKGNGAKRVLGWVAFAADAGARALVRPADVIFASSPQILSPAVGMVVAALRRKPFVVEVRDLWPESLVSGGALKEGSALHKVLQGLEKNHLRPRSPDRRRNEGLGGPLPRTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN4</accession>
    <name>W4THN4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67689">
        <property type="protein sequence ID" value="GAE67689"/>
        <property type="gene ID" value="JCM18909_767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE67689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="218" mass="22209" checksum="7D1C8D4A76351A18" modified="2014-03-19" version="1">MVASASDPVTKGMFTLVDKNDNPLTTTGVVSSVKLSATGVPGHLAEGETPASTFDAHDATPGGGITGSILISPYIKPGTVSSTHYNHFSWLRTMEDIFSVSKGKDTRQLEAGTVSGGLDGAGHLGFAAQAGLGTFGKDVFTNVSAGNEPHPSASTTAGAPSNHPSHSPATHPLSGKPDLPHTGTEGTVDPASNSHASMETGLAVIGAALDTRTWHRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>W4THN5</accession>
    <name>W4THN5_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemA</name>
        <name evidence="13" type="ORF">JCM18909_1128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8"/>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68022">
        <property type="protein sequence ID" value="GAE68022"/>
        <property type="gene ID" value="JCM18909_1128"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="12">
        <location>
            <begin position="20"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="11">
        <location>
            <begin position="123"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="10">
        <location>
            <begin position="261"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE68022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="400" mass="42291" checksum="52B8E4C2F2B83791" modified="2014-03-19" version="1">MCLIVETSPDAVAQGFDEAALRRCIADHGANVLAESAQLVCENDAVWRLFRVAAGMESMVFGEREVAGQMKRALSEARREQTVSYTIGHVVEEALKTSRHVATETALAAEGRTVVAVGLDLVAQRMDLDGARVLVMGTGSYAGASCAQLSSWGVAEIQVHSASGRAAGFARRHRVSEALDIDAALAQADLVVTCRGSGVPALSAEAARRAVDARRGRDLMVLDLAISGDVEEPVPAGVEVIDLETIRQAVPASAEAERAAAEHIIATGVRHFAVDLERRRMAPAVVALRDVISDLVTAELERLPEEGSVPVDEVAASLRRLAASMAHIPSARARMASEQGLGDRWLNSLSDVLGIDVDIAAPVIDMSSFANADCMTCPVTGLRVEDLATDAAPRGEERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4THR0</accession>
    <name>W4THR0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_1055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67953">
        <property type="protein sequence ID" value="GAE67953"/>
        <property type="gene ID" value="JCM18909_1055"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10792" checksum="515EC3F40CA35EF2" modified="2014-03-19" version="1">MPVCFFDLDSDVVKPAGRQIIDRTAKQLVARKVSGKIEVTGYTDSSGSASHNLDLSRRRAASVAKVLGSQLSKGVTLLRRVRGRLIQWRVMIRRLGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4THS3</accession>
    <name>W4THS3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE67968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67968">
        <property type="protein sequence ID" value="GAE67968"/>
        <property type="gene ID" value="JCM18909_1070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15417" checksum="0789B26E6B9B777E" modified="2014-03-19" version="1">MFVIGSMPLTHPSQSTDGDPGRKYEVTWLDLGHLHPSRPGLVTITTTVDDDVITSSQVNVGNLHRGDEKKLFEARDYRQIPMLASRHDWTTPFIGETGAAHAIEDAMGITIPTRVAWIRTLLAEFSRITSHFTFFCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THV1</accession>
    <name>W4THV1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein FtsI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68361">
        <property type="protein sequence ID" value="GAE68361"/>
        <property type="gene ID" value="JCM18909_1490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="17842" checksum="BB64A28C842BCEC6" modified="2014-03-19" version="1">MSSVASRFPQDLTDAQLAQSSIGQFNVAASPLQMAMVTAGIANGGKLMTPYLTAQVRASNLQVVSEHHPRQMSQPMTKESAEQLKAMMVSVVNNGTGKRARINGTTVGGKTGTAQTVQGKAPYAWFVGWSDNPHVAVAVFIQSSDTAINEISGGRLAAPIARDVIEAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI48</accession>
    <name>W4TI48_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68207">
        <property type="protein sequence ID" value="GAE68207"/>
        <property type="gene ID" value="JCM18909_1329"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="127" mass="12969" checksum="A6164C6F4EE047FE" modified="2014-03-19" version="1">MGGDATFVVGGATTIETLAFGGGDEGSVCHSSRLPVGWTSPWEYSRTVGIPSGAGQWAMTAGRPSFSVTTVTSAAPASLAAAATNSAPDLTSSGRWELTDRTATWRVSCSTASSKPESTLADRLLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI65</accession>
    <name>W4TI65_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanyl-specific ribonuclease Sa3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68650">
        <property type="protein sequence ID" value="GAE68650"/>
        <property type="gene ID" value="JCM18909_1800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004849254" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="5703" checksum="E311AE85C205F7CD" modified="2014-03-19" version="1">MTLLAAVVVGCSTPGNVAAAGSNATTAPMTVMATTQSSVGLATIQENELPTGSADSQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIJ3</accession>
    <name>W4TIJ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68601">
        <property type="protein sequence ID" value="GAE68601"/>
        <property type="gene ID" value="JCM18909_1748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="38" mass="4216" checksum="252AACED88E2ECE0" modified="2014-03-19" version="1">MKIFAPTSDTTVIHPGHGDATTVGEERPNLPLWRARGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIM5</accession>
    <name>W4TIM5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000012">
        <property type="protein sequence ID" value="GAE68636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68636">
        <property type="protein sequence ID" value="GAE68636"/>
        <property type="gene ID" value="JCM18909_1786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="131" mass="15066" checksum="ACDE35BC39BDA924" modified="2014-03-19" version="1">MLARGEVRNYKLSTLSRLFHTTTTPSHRALADARATVDVLHGLIDRVGNLGVTTLEDLLEMTHRVPQARRRRRAWAKDLPKGPESIGFAWINLHQHIRRSSMSVSRSTSDAEYPNTSQHRKHDATWTRWCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIN6</accession>
    <name>W4TIN6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68825">
        <property type="protein sequence ID" value="GAE68825"/>
        <property type="gene ID" value="JCM18909_1989"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5442" checksum="CF75BDC34E906BB3" modified="2014-03-19" version="1">MDLDTRRHQLGEGIANSDVVVAPSRRINDDRGPVISGLMNPPIIRSSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIY4</accession>
    <name>W4TIY4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68383">
        <property type="protein sequence ID" value="GAE68383"/>
        <property type="gene ID" value="JCM18909_1518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="138" mass="14373" checksum="2AC50267FCFB1753" modified="2014-03-19" version="1">MPFRVMVTYSHDGKVSSDPSLVSGADGMVGMDVTIYNTTGRLETVSADVDGHAVSREALISTPMTMAGSAVLDGVDPSKVVTAANRSKRTDPAGNGVIGVNKSGKTVVQWAALTGMPLSAPWLASPWSSMPMTSTFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ08</accession>
    <name>W4TJ08_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Isoleucyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68915">
        <property type="protein sequence ID" value="GAE68915"/>
        <property type="gene ID" value="JCM18909_2088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon_1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="351" mass="38536" checksum="A8E05755B63542EC" modified="2014-03-19" version="1">MLVRDVTEALNNFDTQRVGNLIAQFVDELSNWYVRRSRRRFWDGDEGALWTLHETLETLTKLMAPMVPFITERVWQDLFVTTNPHGPESVHLASWPVADDSLIDESLSESMDLARRIVELGRGARVEAKAKIRQPLSRALISGAALAKLDEDLQAEIRSELNVMALDSFTAAGDLVDHCAKGNFRALGKKYAKATPKVAAAIAAADPEWLASELAIKGSVELDVPEVEGGKAVVTADDVIVSERPREGWSVVNEQGETVALDLEITPELARAGQAREVIRFVQDSRKKAGLDVSDRITLAWSASADLAKAIEEHAEQISQEVLAIQMSRGPRADDWAVEPDLGLAVKVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ52</accession>
    <name>W4TJ52_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68975">
        <property type="protein sequence ID" value="GAE68975"/>
        <property type="gene ID" value="JCM18909_2153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16593" checksum="D8FA104DBE59CD2C" modified="2014-03-19" version="1">MPTPRLIVADVTATSQNDLYAQVNDRLTADNMVKSTFLNAVSAREKKFPTGLDFGYVSIAIPHIDPEHVISPGLLVCRNSASTTFHAMDDPERNLDVQLSIWPLVTDPGNQIDMLGAVIALIQDESSYRILLHGNHAEVANTLPDVLATVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ56</accession>
    <name>W4TJ56_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0301 (AlgH) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68428">
        <property type="protein sequence ID" value="GAE68428"/>
        <property type="gene ID" value="JCM18909_1566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="291" mass="31230" checksum="84E5C37C27B0D784" modified="2014-03-19" version="1">MMKYLALFLAFEIRWSSRVVGDGMPVGAIGSSAPPGIPSGLIGPGASTFRTGPSSHPCGAWQQPDNSLARRIEVESGLACDDLESPLTITPRRLILGDTMDLVILANPLKVGDLLVASRQIDEGIFYESVVYLIDVALDGVLGVIVNQLCTAGTLHRQLPGWVHLATPPQDLFLGGPMSPNGAICLARVQHSSEEPPGWRRVQGLTGLLHLDTPTELVEGAFTDVRIFAGYAEWVPGQLEAELIRGDWIRAVAHPEDIFSSEPRGLWRAVLHRQNGPAALLATATDTPALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ73</accession>
    <name>W4TJ73_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_1331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000007">
        <property type="protein sequence ID" value="GAE68209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68209">
        <property type="protein sequence ID" value="GAE68209"/>
        <property type="gene ID" value="JCM18909_1331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE68209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="96" mass="9605" checksum="584D2279AE1A99B9" modified="2014-03-19" version="1">MPSGSVSYRTLFSLPGGTFVTVSALARLPLAMSQLGTLLLVSSPQVSGRLGPGGLAAGVVALAIAIGSPFFGALTDRHGQRVVLLAQSLVGGTADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJN6</accession>
    <name>W4TJN6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68354">
        <property type="protein sequence ID" value="GAE68354"/>
        <property type="gene ID" value="JCM18909_1483"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19644" checksum="B5AA4836ABBDFBF5" modified="2014-03-19" version="1">MRRRYADLVVREESRQMVRTRAVITRAVRRALDERGFLEIETPILQLVHGGAAARPFNTHLNAFDIDMSLRIALELYLKRAMVGGTDRVYEMGRVFRNEGIDSSHSAEFSMLEAYMSWGNQFTIAEVIKDIIMAVADALDVHQIETPKGTIDLDGQWRWVSVYPGLSEKTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-02-10" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJQ4</accession>
    <name>W4TJQ4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">JCM18909_1924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68767">
        <property type="protein sequence ID" value="GAE68767"/>
        <property type="gene ID" value="JCM18909_1924"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPG_CAT" evidence="10">
        <location>
            <begin position="26"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GAE68767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="253" mass="27769" checksum="08DEFB958F0D6B7C" modified="2014-03-19" version="1">MKLSCLNSLHLFDFHDAMTTYPRGQPTVPEGHVIHRLANAIDSAFAGSRVEVTSPQGRFAESAAMLDGTVLTSVQAWGKHLVVDFDNHRPDHLLHIHLGLIGKLAVGPTVPVVGQVRLRITDGVTAADLRGPQTCELINDDEWGTVAATIGPDPIRDDADPDVAWDKVRRSSRRISDVLLDQRVAAGVGNIYRAEVLFRHRVDPATPGKQISHSTWLAMWDDLVMLMRAGVESGRIDTVQPEHIPEAMGRPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT4</accession>
    <name>W4TJT4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Septum formation protein Maf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68792">
        <property type="protein sequence ID" value="GAE68792"/>
        <property type="gene ID" value="JCM18909_1955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12105" checksum="5241CA79B7F4A3AB" modified="2014-03-19" version="1">MDDAITVTKGNLTDEELGALVAVVAELTRPGPNATCLMTDRSPSAGNRIGVPSVNLLCPARQPGVDLCDATDMTTCFVLASKSPARLRMLRSAGIEPVVIASGPMRVICAGRTRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJT7</accession>
    <name>W4TJT7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69051">
        <property type="protein sequence ID" value="GAE69051"/>
        <property type="gene ID" value="JCM18909_2233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11471" checksum="34B9DC8375A8346D" modified="2014-03-19" version="1">MIGLLGAKIWKENEVDFGNPVNLVPVAAGIIIGVGDVSLKFSKSFTLGGIALGTIVTVGVYHLAKWLAPHELSDAAGGTNIILDAPGMYVDDDTPSNRDHDGGDQRRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK62</accession>
    <name>W4TK62_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68524">
        <property type="protein sequence ID" value="GAE68524"/>
        <property type="gene ID" value="JCM18909_1668"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7102" checksum="3EB5404AC8394690" modified="2014-03-19" version="1">MSDEKFVLAIDEGTTSARAIIFNHAGQIVAVGQQEFEQIFPRAGWVEHDPIEIWELFATSLGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK81</accession>
    <name>W4TK81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69360">
        <property type="protein sequence ID" value="GAE69360"/>
        <property type="gene ID" value="JCM18909_2568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8048" checksum="C678A71AA6B9E604" modified="2014-03-19" version="1">MSTLVIPTTAFSLFIIWNFRGSVVDPSAILVVGMVIVCAVAREPFSFGRGAPHCTRTYVVCLDEVSDGVLTVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK90</accession>
    <name>W4TK90_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_1706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68559">
        <property type="protein sequence ID" value="GAE68559"/>
        <property type="gene ID" value="JCM18909_1706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006561">
        <property type="term" value="P:proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="225"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE68559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="337" mass="35527" checksum="8AF49EC74E91166A" modified="2014-03-19" version="1">MSSGAIATGFPAMGITHRPRTLAGKQAAASVGQGILLAHYASRFASHGLRVGQVLLTVNDLVRPTSYRNAWSTLDTLLGLGVVPIVNENDTVATGEIRFGDNDRLAALVAELVRAQALILLSDVDALYTAHPDSPDARRVEVVEDIDALDVDTHKAGSGVGTGGMTTKIEAARMATCAGVPVVLAAAVDARDVLAGAPVGTYFRPLATRRPRRLLWLADAATPQGQIVIDDGAVEALTQRHSSLLAVGVTRVHGDFQAGDPVTILASDGRVVGRGIAQFSHDEVRVMRGRSSAWLAAEMGPAASREIIHRDAMVLSRRRKAEPSSRNQKSSGSRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF5</accession>
    <name>W4TKF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">cAMP-binding proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68903">
        <property type="protein sequence ID" value="GAE68903"/>
        <property type="gene ID" value="JCM18909_2075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13026" checksum="AC2E8A165AFC6173" modified="2014-03-19" version="1">MRELVKGRHDVALAMLGRLSERLRRADDNTAHFVSGDVPSRLAYTLLDLARRFGTANPSTGHIVVRHDLTQHELAQAVGSSRETVNKALTDFAARGWIAARPKVVTIMEPEKLASRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF6</accession>
    <name>W4TKF6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppk</name>
        <name evidence="13" type="ORF">JCM18909_2186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69007">
        <property type="protein sequence ID" value="GAE69007"/>
        <property type="gene ID" value="JCM18909_2186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="10">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="9">
        <location>
            <begin position="138"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="12">
        <location>
            <begin position="344"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="11">
        <location>
            <begin position="517"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE69007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="701" mass="79185" checksum="9F3BF19EB344C110" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKF9</accession>
    <name>W4TKF9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69420">
        <property type="protein sequence ID" value="GAE69420"/>
        <property type="gene ID" value="JCM18909_2630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="251" mass="26711" checksum="65DD68B2E61C7FB2" modified="2014-03-19" version="1">MIVEQAHSVGAVMVVDASQAVPQMPVDVTTLGADLVAFTGHKMCGPTGIGILWGRYDLLAELPPFLGGGEMIEVVRMEGSTYAEPPHRFEAGTPPIAQLAALGVAADYLDGIGMQAIAEHEHELAARMLEELQTVKGVHILGPSDATGRTGTVSFTIEGVHPHDAMSIMDGHALRCEAVTTAPGRCMRDWEYSPPSVRRHTCTPPPTRWIASSNLSSTLGTSSPEVRHECRRDIPADHPGPLPGEASQRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKH7</accession>
    <name>W4TKH7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68913">
        <property type="protein sequence ID" value="GAE68913"/>
        <property type="gene ID" value="JCM18909_2086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021144">
        <property type="entry name" value="UPF0597"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30501">
        <property type="entry name" value="PTHR30501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="182" mass="18929" checksum="4086DC79360CA5A3" modified="2014-03-19" version="1">MAVMVPGTGRPGLEIAAAVGAPAGNPDAGLAVLADVSEDAAEKARHLVDSGAVELTVADVDDDLYAETVLHLDGHHARACIAGDHTNVFLVSRDDEVLESKERPAAGHVPPTAALLQGLSLAKIYDFATTVDIKLIEFITEPNASTTPWSTLDETAPTGLVKVPPYSDQSTAAWPQTTCAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKL2</accession>
    <name>W4TKL2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000017">
        <property type="protein sequence ID" value="GAE69067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69067">
        <property type="protein sequence ID" value="GAE69067"/>
        <property type="gene ID" value="JCM18909_2250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850798" evidence="2">
        <location>
            <begin position="32"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="408" mass="44038" checksum="6A38E13723CF1CDB" modified="2014-03-19" version="1">MWPIRTVRAYCAGTVATAVALAAFVTSGAHAAGTRETSKPQAYPVPGLFHPCSGSVTPDWHYGETSRHYQSDGTLQFTNQTDHAVDYTASVKTSTNHKIDSNSASKLPPNWNTTLKTELGIVASNGWQDKETFGPVKLGPGESFRVEYGVTVKNFVGMFLGCRDGYLEPSGGANVIQGTAPAERYAYALVIHKDGSISDRALAIPSRGSGKNSRIVDDHDIVMAGPNLEKLADPSKDVPVEPTSPLQRDPSWPKQGERCPARGWYPLDISGIDPLIRQPGYSQDFLNWSKGQYHFTPVTDTVVGAQFAGYVNWDPAADGPPRGWLESVGAIYRAYLPVKTELRGVDLAPGEKVHVEYGTLLRRVNYREVGCKNGVASIVSHYGLASAPAGFWLKPLLPALTGPNAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKP2</accession>
    <name>W4TKP2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate regulon transcriptional regulatory protein PhoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_2161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE68983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68983">
        <property type="protein sequence ID" value="GAE68983"/>
        <property type="gene ID" value="JCM18909_2161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE68983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="226" mass="25265" checksum="173E59A16486059F" modified="2014-03-19" version="1">MTRVLIIEDEESYREATAFMLRKEGFEVNTAANGADGLEIYSRNGADIVLLDLMMPGLPGTEVCRQLRQRGNVGIIMVTARDSEIDKVVGLELGADDYVTKPFSHRELVARIRAVTRRGGPEVEVSPDVLEESGVRMDVERHEVSVEGTVVRLALKEFDLLEVLLRNAGRVMTRASLIDRVWGADYVGDTKTLDVHIKRLRAKIEDDPSRPVRITTVRGLGYKFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL46</accession>
    <name>W4TL46_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69451">
        <property type="protein sequence ID" value="GAE69451"/>
        <property type="gene ID" value="JCM18909_2667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="210" mass="22127" checksum="89C535817B3F8995" modified="2014-03-19" version="1">MYSPTVDVADDGAAYQEVRMGLGWLDDAAFTLGTELSVDKILHEGVRTSVARCWVDGSTTATAGARTVVAKCFRSTSMSHNSGGLGIVREVAGLGCLPEAPRLYAADLSLGVVVMEDVSGMTLESILTGNDPSAALIAAQMWGRATSTVMAASMREMSDRAARDEVIPAFQDAIRRLDPQTRSAGGPASPRLPGPGLEKNVRGARDRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL80</accession>
    <name>W4TL80_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP-binding protein EngA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2391</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000019">
        <property type="protein sequence ID" value="GAE69198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69198">
        <property type="protein sequence ID" value="GAE69198"/>
        <property type="gene ID" value="JCM18909_2391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngA-type G" evidence="4">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="257" mass="28807" checksum="AE5E0A1FB1A66F8B" modified="2014-03-19" version="1">MGKPNVGKSSLLNRIARQNRVVVSDISGTTVDPVDELVTVGGTVYQFIDTAGLRKRVKEASGHEYYASLRTQAAIERAEVCVVVIDASESISDQDLRILTMVENAGRAMVIAYNKWDLTDEERRRYLEREIERDVQAYSWAPRVNISALNGRNVDKLEKAIETAAEGWETRISTGKLNAFLGRLAAAHPHPVRGGKQPRILFGTQAHNCPPTFALFTSGVFDQGYVRFIIRRLREDFGFAGSPVHVEIRPRAKRQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL81</accession>
    <name>W4TL81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor LepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69735">
        <property type="protein sequence ID" value="GAE69735"/>
        <property type="gene ID" value="JCM18909_2984"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LepA_C" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14292" checksum="00AAC6B89D0709C9" modified="2014-03-19" version="1">MDALSSIVHRDKSYSYGVAMAAKLKELIPRQQFEVPIQAAIGARVIARETIRAVRKDVLAKCYGGDISRKRKLLEKQKAGKKAHEVVGSVEVPQEAFVAALRTGESTEKKSEGSEGLPIKRSAHAGRSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLU9</accession>
    <name>W4TLU9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69726">
        <property type="protein sequence ID" value="GAE69726"/>
        <property type="gene ID" value="JCM18909_2975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="31"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="340" mass="36282" checksum="70F2AB3352F660F2" modified="2014-03-19" version="1">MQTSLAHWRGYRSCGILGQVNSVYGTALLVQGAEALLSDRAVDARIKAARREFPDAELVELEGREVDAGRFVEATGGSLFSQATIVVVNAVSDLDKDLFDLVATTAANPPDTLCLILVHPGGVKGKRLLTKLTKAKVETAKADVPKPWAIPDFIAKEARRGHLDMDRDAVNALHQALGNDLRTLAAAVGQLASDSLNGRVGAEEVTTYFGGRAEISSFNVSDASLEGRLPDALETLRWALSIGVQPAAVTAAMARGLRSVGLYLDLRSQRMGDKQLAQTIGVSPWKLKSLNKQARSWSKAGVARAIRLVNTCDAAVKGAAVDPDYALESMLIAIEKARQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY0</accession>
    <name>W4TLY0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000028">
        <property type="protein sequence ID" value="GAE69756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69756">
        <property type="protein sequence ID" value="GAE69756"/>
        <property type="gene ID" value="JCM18909_3007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9770" checksum="23470217CA27E3A3" modified="2014-03-19" version="1">MTCHNNVAGHYDGTVSNHHLLTQANVAPVDENGVTVGIVGTIAFAVASLICWIILDRLTETGYRDWLWVCLTGTGLGAVGTAYCWQRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLY8</accession>
    <name>W4TLY8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69542">
        <property type="protein sequence ID" value="GAE69542"/>
        <property type="gene ID" value="JCM18909_2769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="7">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="6">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="323" mass="33875" checksum="17A040D4417E8A9C" modified="2014-03-19" version="1">MSQPPHAIAADHQTPTIGTAWSAEEGATRARHLFGGHIGGSPDGVWAAPGRVNIIGEHTDYNNGFCLPIALPHRTYVAARRRDDDKVILVSQLDDSVLTWEGTLDEIAPGSVAGWKAYTGGVAWALRQAGHGLGGFEAALVTCVPLGAGLSSSAAVECGVGLALADLYDLDLTDSDSGRIELVNTARAAENEVAEAPTGGLDQTASLRTTEGHALLIDCDDWSVRQVPFNLDTADLELLVIDTCAPHRLVDGQYEHDGGPARMPHASSELVACVTSVTWGPPWPPLMTKGWLAASATSSLRTTALPSSLSSSMPAKSAKWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM38</accession>
    <name>W4TM38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69463">
        <property type="protein sequence ID" value="GAE69463"/>
        <property type="gene ID" value="JCM18909_2680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17230" checksum="31078EB0E4E3ED4B" modified="2014-03-19" version="1">MPLVTLGGVRESIVSFMAMDDLWRRRVPEHKGWQIPVVWFLPAADVLVGALVALAVGAGGLLLAALQDHLDTLGPGDVIVVIVLAVALSFRRVMPITSAAVMTLVWINGTYATPYMATNWVSTLAFFSSPTTPSWCGYGHVESRGDRCWRSSSSSWAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TM60</accession>
    <name>W4TM60_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-coenzyme A synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000023">
        <property type="protein sequence ID" value="GAE69488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69488">
        <property type="protein sequence ID" value="GAE69488"/>
        <property type="gene ID" value="JCM18909_2708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACAS_N" evidence="2">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="107"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="490" mass="55516" checksum="3ED4388F94EBF3D5" modified="2014-03-19" version="1">MVPSFPTCRMPQQRWEVEEDRMTNQQDVFEPDQNIVDNAWVSDWKTLEGKARAGPIAYWDEQAQELEWSKPWDKVLDDSNKPFFQWFTGAKTNIVTNAVDRHLSTARRNKLALIWVGENTDEVRTFSYFALNREVEQMANVLKAMGVRKGDVVTIYLPRIPEIFFSRCWPAPRLVRCIRWFFAGYSSEALNARIDGSESKVVITVDGSWINGKVFPMKQIVDDAVKFSPTVENVIVVRNTKIEVSMDSTRDHWYDELCKLPIAKGKCETVQVDAEDPLFILYTSGSTGKPKAIVHTHGGYQVGTYITLKQCFDIKEEDRWWCTADPGWITGHSYLVYGPLLNGATVFMHEGGPTYPYPDGWWQLIEHYGITSFYTAPTAIRTLMRFGDAGCANTICPVCAYLVRLASPSTRRLGAGSTMWSVTARVRSPIPGGRPKLACSRSPLCRRCRSNQVPLGVRSLARRLLLSTRRAMSSLRAQRASSSSKTRGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD6</accession>
    <name>W4TMD6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5-keto-2-deoxy-D-gluconate-6 phosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000025">
        <property type="protein sequence ID" value="GAE69573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69573">
        <property type="protein sequence ID" value="GAE69573"/>
        <property type="gene ID" value="JCM18909_2806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="198" mass="21399" checksum="C8D922B624C0C851" modified="2014-03-19" version="1">MTRTPLIDKLLDRRLADPVRFADRVRQRPRATWSPTEPLMVVAADHPARGALAAGGRADAMADREHLLERCVTALGRPGVNGFLGTADMVADLANLDALDGKVVFGSMNRGGFAGASFELDDRMTGYDVQGILDEDLTGGKMLLRFDLSDPGTATTAQACAEAVTTLARARRIAWWNRSSPTVLTMARSSTIFPLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME4</accession>
    <name>W4TME4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="4">2.7.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_2956</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69707">
        <property type="protein sequence ID" value="GAE69707"/>
        <property type="gene ID" value="JCM18909_2956"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE69707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17768" checksum="77B11D42B277A7CF" modified="2014-03-19" version="1">MTELSNLVAESVERLRRDKPLVQCLTNIVVANFTANVLLSAEAVPAMVDNPEESEGFASIADGVLVNTGTPYRETAEAMIAAARGAASSNTPWVLDPVGVGMPWRTRVALDTLDVAAPAVIRQTPLRCWHWPVLVPPLEARRREMLLRMPWRPRLSSSAITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TME8</accession>
    <name>W4TME8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent malic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000027">
        <property type="protein sequence ID" value="GAE69712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69712">
        <property type="protein sequence ID" value="GAE69712"/>
        <property type="gene ID" value="JCM18909_2961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic_M" evidence="1">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9294" checksum="A0F0EAACA27459D5" modified="2014-03-19" version="1">MLSAVKSSGIPLNDHRIVIHGAGSAGTGIANLLVQLMVSQGADEKTARSHFWGLGSHGLLREGLRLRDFQQPFARGKEELEDWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMI8</accession>
    <name>W4TMI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69911">
        <property type="protein sequence ID" value="GAE69911"/>
        <property type="gene ID" value="JCM18909_3178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24321" checksum="06C09271461D5CB4" modified="2014-03-19" version="1">MWWIWVLIFAGVLLVVEIVVGAIWLWRKLAAILGEVERVTGRLDELAHILEDVDTTMNKDMTAPEAPDHRGSLNADRRVGSLPVRYGDGMPAKSGRRASMAPLLIANEATIIIIVLLALVLFGGSRIAGVGKGAGRAIREFKEETAGLNKGKDAKTEKDIEATELTSPRTRPSQLSESWPWILGSPMRITAGLPDSVRPRLGRAAQCRSWTTSGSSVTGSLCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMK4</accession>
    <name>W4TMK4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69931">
        <property type="protein sequence ID" value="GAE69931"/>
        <property type="gene ID" value="JCM18909_3200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE69931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12992" checksum="6C9FD37D0598D2C7" modified="2014-03-19" version="1">MRLALEVVVAQPQVPQTFVFDEIDSGVGGAVGIEIGRRLRQLARRHQVIVVTHLAQVAAFADTHVVITKASDGAVTSSGLREVTGSDREIELSRMMSGMVDSESGLEHAHDLLREADEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMM9</accession>
    <name>W4TMM9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000022">
        <property type="protein sequence ID" value="GAE69429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69429">
        <property type="protein sequence ID" value="GAE69429"/>
        <property type="gene ID" value="JCM18909_2641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="86" mass="8877" checksum="6455D35E098156E0" modified="2014-03-19" version="1">MLSGGEKTRLALATLVVSSANVLLLDEPTNNLDPASRAQVLDAIGNFGGAIVLVTHDEGAVHALDPIVCWSCPMAPKICGVLITPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMZ8</accession>
    <name>W4TMZ8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA repair exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000043">
        <property type="protein sequence ID" value="GAE70350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70350">
        <property type="protein sequence ID" value="GAE70350"/>
        <property type="gene ID" value="JCM18909_3664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="132" mass="14545" checksum="18BDBFD02CC5A6F3" modified="2014-03-19" version="1">MSQEVAGEADLQTLRDRFDSFDHRDRTIIRYDLHGQVTISQKAKLDEIIADYETVFASLEPSENRHDLTVVGDDVSLTEADVPGWVRDAAEELSDMCATSEDAVAALTLLHRLISAEEVGTATTAHTAEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA3</accession>
    <name>W4TNA3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69888">
        <property type="protein sequence ID" value="GAE69888"/>
        <property type="gene ID" value="JCM18909_3153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="67"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="239" mass="24921" checksum="EDFA24E0649040A7" modified="2014-03-19" version="1">MDESSGVGVLDKAALVLAALETGPASLAGLVQMTGLARPTAHRLARALEHHRFVGRDLQGRFILGPRLSELAAAAGEDRLLAASGPILARLRDITGESAQLYRRQAGSRVCAAAAERPTGLRDTIPVGSVLSMDAGSAAQILLAWEGVDKIRRGLSHSAFSEITLAAVRKRGWAQSVGEREAGVASVSAPVRSPSGKVIAAISVSGPIERLTRQPGRIHAPAVVAAGERLSEVLRRSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA7</accession>
    <name>W4TNA7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-3-phosphoglycerate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70430">
        <property type="protein sequence ID" value="GAE70430"/>
        <property type="gene ID" value="JCM18909_3748"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16613" checksum="D41D7A35A4179A11" modified="2014-03-19" version="1">MRLALFCIGTNQMDLDALAEAGVPAFNAPYSNTRSVVELVMAEIIALARRLGDRNTQMHNGVWRKSAIGSHEIRGRRLGIIGYGNIGQQLSVVAEAMGMQVFFSMTSLMFYLWATLTSVIPWKSCLVASRRCLFMSMDAPATPILSGIANSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNB7</accession>
    <name>W4TNB7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmB</name>
        <name evidence="6" type="ORF">JCM18909_3302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70022">
        <property type="protein sequence ID" value="GAE70022"/>
        <property type="gene ID" value="JCM18909_3302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="PTHR13528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="48" mass="5734" checksum="74F6A3DA811C79A9" modified="2014-03-19" version="1">MSRRCQVRGTKPGFGNNVSHSQRHTKRRWNPNIQKKRYWVPSLVEKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNC0</accession>
    <name>W4TNC0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70027">
        <property type="protein sequence ID" value="GAE70027"/>
        <property type="gene ID" value="JCM18909_3307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PTHR45779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12162" checksum="3707C4FBCD22CB04" modified="2014-03-19" version="1">MTLPDSAPDDLVVEDITIGDGPEASAGNLVEVHYVGVALSNGREFDSSWNRGEPLTFQLGAGQVIPGWDEGVQGMKVGGRRKLVIPHHLAYGPQGIPGVIAGGETLVFVCDLVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNF1</accession>
    <name>W4TNF1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Two component sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70485">
        <property type="protein sequence ID" value="GAE70485"/>
        <property type="gene ID" value="JCM18909_3812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="308" mass="34632" checksum="F16CD019FF2B8B64" modified="2014-03-19" version="1">MEDTGSQTLPTENRSNGSRGAGVRARLNRFNPSRNNVPQINIPGMEEVLDPKLDDGRPADTERAWWGDVTLTLIMAVVTIAPYLVSLVEWPRPEYIAALLSSMVMVASLPMRREHPLLMMTLVAIGAAIQFFFVPFPVLSIFVVPIASYSVARWVDGHQSRWVLWVGAVGSVIGPMRWIPTIAAGYDPSSGTPWVLLVLAMTVCAGLVLTPYAVGRRLRESALIDSQQRIVKAQRYRAILAEREQQARVAEERTRNEIARELHDIVAHSLSVMIVQPKAAKHWRQRSRRRPPRCLRRSPRPDVRPSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG9</accession>
    <name>W4TNG9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000049">
        <property type="protein sequence ID" value="GAE70505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70505">
        <property type="protein sequence ID" value="GAE70505"/>
        <property type="gene ID" value="JCM18909_3833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="43" mass="5134" checksum="68A5B47BF35BBF2E" modified="2014-03-19" version="1">MWRWRHRCKVIYDAHEDLIGQVDTKPYLGAVTRPLARWPLGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNM2</accession>
    <name>W4TNM2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70137">
        <property type="protein sequence ID" value="GAE70137"/>
        <property type="gene ID" value="JCM18909_3433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="631" mass="70992" checksum="5F4A1E4C736C66CD" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNR1</accession>
    <name>W4TNR1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70366">
        <property type="protein sequence ID" value="GAE70366"/>
        <property type="gene ID" value="JCM18909_3682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="472"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="588" mass="64680" checksum="FEE5329338609926" modified="2014-03-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNS3</accession>
    <name>W4TNS3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycine betaine ABC transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">JCM18909_3693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70376">
        <property type="protein sequence ID" value="GAE70376"/>
        <property type="gene ID" value="JCM18909_3693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="34"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GAE70376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="238" mass="24260" checksum="B741DB31A2916D78" modified="2014-03-19" version="1">MAEGSDDMNHIAAALTWLTTSSHWAGSGSIGVRIGEHLWYTLLALTVAAIIAIPAGLAIGHTGRGKTIAVACSGALRALPSLGLLTLLAISTTIGIENPIVPSTIVLAILAIPPLLAGSYSGVDAIDDEVADGARACGMTEMQVLSRVELPLATPLLLGGLRSAALQVIATTTICSYLGMGGLGRFILDGLAVSDYPQMLAGSIVIIVLALVVDGLLCLVTRLLTGPGIRHALALTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNT9</accession>
    <name>W4TNT9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-serine/D-alanine/glycine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000058">
        <property type="protein sequence ID" value="GAE70630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70630">
        <property type="protein sequence ID" value="GAE70630"/>
        <property type="gene ID" value="JCM18909_3988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6626" checksum="D88139685E6B240E" modified="2014-03-19" version="1">MCWVVIGNADTIAICGYLAAWFPHLDKWIPATCIVLLLTCLNMVAVKLFWRDGILVCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNW4</accession>
    <name>W4TNW4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_4036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000061">
        <property type="protein sequence ID" value="GAE70665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70665">
        <property type="protein sequence ID" value="GAE70665"/>
        <property type="gene ID" value="JCM18909_4036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="334" mass="35497" checksum="AB8E9FCED1C9B91A" modified="2014-03-19" version="1">MPVEVADTALDLIAEGVRTTGRPAHVQLAGGEPTLVPSLIEHVAKRVVEIRWGKVTCGIQTNAARLDANIIAMLKRHSVRVGVSVDGPPPVQEKTRGSAAQTFRGLLALAHADIPVRVTTVLSALNVEHLDELAVTLAALPNVTGFGLDPLVAIGSATGRDDLVPGNEAVINGITTLYRRLAQINALRATPLRWRELETVRTALRRGPVPTTSAVDPAGRTLLPVANHPYCHAAVGESMAVAPDGSVYPCSQTVGDVASRAGTVHSIDWESLRRRFSQDRHTLRGPCHRCALAGRCPGDCSSRVEADALADPEQRRTPLTCLIDSTLAHLESAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNX2</accession>
    <name>W4TNX2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein mosC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000035">
        <property type="protein sequence ID" value="GAE70108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70108">
        <property type="protein sequence ID" value="GAE70108"/>
        <property type="gene ID" value="JCM18909_3399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014841625" evidence="2">
        <location>
            <begin position="27"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="337" mass="33965" checksum="C9F07EDB24ACA22F" modified="2014-03-19" version="1">MAVVGTVVLAAAVALAGWSGCGFALAACIFFAGFFDAIVDVAQNVVGVAVQDNSGRSILSSMHALWSLGGVISGAASTAAATAGTDMRLYLAVVGFVCIILVGIGGLLVGNAPVMPKSNDEPSASSGKGRLQWWFVLRAALPLAVIATCGTTIEDVANNWSAIAAVQIGNVPAASAGVAFSVIIGSQCLGRFSGDFLIQKCGRIRIARFGGVFIVFGGLAIVTAQEPIRLIIGLAAVGYGAATLVPSALGSAAHIPGVSSASGVTLVNWIMRVGFLVTSPLVGVITTATSLRWGLSVLLPIGFVAVVLASTLNPVENVPAPKGRDAPKRDVTISPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP31</accession>
    <name>W4TP31_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69944">
        <property type="protein sequence ID" value="GAE69944"/>
        <property type="gene ID" value="JCM18909_3214"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="160" mass="16654" checksum="99424F03E0CC9A9D" modified="2014-03-19" version="1">MDGSVIDRAIIAMAVAAPILPNVTTTVMLILVVPPIPTKISTTLTVSTRATVITPRTVCVTFALWFTIIIPATPAIAPWLAVIVPATPAVSPATLMVTATVTGLRGPTAASARLTGPSVAARASTASARSTIIRGGRICHADILPHRWASWRTDRDTPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP39</accession>
    <name>W4TP39_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpD</name>
        <name evidence="13" type="ORF">JCM18909_3227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69954">
        <property type="protein sequence ID" value="GAE69954"/>
        <property type="gene ID" value="JCM18909_3227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="161"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GAE69954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="501" mass="54739" checksum="E928A849294834EE" modified="2014-03-19" version="1">MTATTITPETKDEVVGVGRVVRVIGPVVDVEFPAGQLPEILNALHVDTEVMGETHTITLEVALHIGENVVRAISLKPTDGMRRGTEVHDTGAPISVPVGDVTKGHVWNVTGDVLNADPSTIEVTERWPIHRDPPAFDDLEPETEMLETGIKVLDLLTPYVKGGKIGLFGGAGVGKTVLIQEMIYRIAHNFGGTSVFAGVGERTREGNDLINEMDEAGVLKDTALVFGQMDEPPGTRLRIALTGLTMAEYFRDVQNQDVLLFIDNIFRFSQAGSEVSTLLGRMPSAVGYQPNLADEMGQLQERITSTRGHSITSMQAVYVPADDYTDPAPATTFAHLDATTELSREIASRGLYPAVDPLTSTSRILDPLYVGQEHYDTATQVKQILQRNKELQDIIAILGVDELSEEDKVTVARARRIQQFLSQNTYTAEKFTGVAGSTVPIADTVEGFQMICRGDVDHIPEQAFFNVGSMDMVMENWDKMKKEAESYGPPAASSQGRQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPA6</accession>
    <name>W4TPA6_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-formylglutamate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70034">
        <property type="protein sequence ID" value="GAE70034"/>
        <property type="gene ID" value="JCM18909_3314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6328" checksum="F872882723F9B1D7" modified="2014-03-19" version="1">MTTWTAASLLAEIAAIGRNEDGSYSRFCLRPEEVAAGMVRRKSHRVRVGDRHGRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPC5</accession>
    <name>W4TPC5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-proline glycine betaine binding ABC transporter protein ProX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000044">
        <property type="protein sequence ID" value="GAE70377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70377">
        <property type="protein sequence ID" value="GAE70377"/>
        <property type="gene ID" value="JCM18909_3694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004850863" evidence="3">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="4">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16451" checksum="E56E9409B9F0FAB5" modified="2014-03-19" version="1">MITTPMTRRTLLGTALLTGLAACSSNDPLNSDGSGYGSADLIVGSANFTESEIIAEVYAQSLEEVGITVKRRMQIGARDVYVKALQDGSVDLVPEYSGNLLQFFQGHRPPPMRSPSWPPCAKPCPPVCRSENPRQLKMPIPGASPPNSHTPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPF5</accession>
    <name>W4TPF5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lead, cadmium, zinc and mercury transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70606">
        <property type="protein sequence ID" value="GAE70606"/>
        <property type="gene ID" value="JCM18909_3957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="396" mass="42328" checksum="C8709F1E8B6FD8E9" modified="2014-03-19" version="1">MSTAAMSPPDEEQTVLHPPVQLQISGMTCAACATTIEKRLSRIDGVHASVNFASERATVTGMGVKDAIAAVKDAGYTAALLSDIDLAAEAERRITMLRRRLIVAVLLTLPLMDIGLVLALEPQLRFPAWDWLLVSLSLPVVFWSAWPFHKATWTNLRHGMTSMDTLVSLGVLSSFGWSFISILIGAQDQEGYWLGYGITPAGADTLYLDVAAGVTCFLLAGRYFEARAKRSARSVLTALRQLAAKNARVLRNGIETVVPVEQLHQSDLFVTLAGETLAADGEVVEGSSSIDTSMMTGEPIPADVTVGSAVLGGTMNLTGRIVARATGVGDHSQLAHMAVLAEEAQARKANVQRLVDKVVEIFVPAVLAIVVLTFFGWWIAGAGTGMPSRQASRCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPI3</accession>
    <name>W4TPI3_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">JCM18909_3725</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="BAVM01000045">
        <property type="protein sequence ID" value="GAE70407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70407">
        <property type="protein sequence ID" value="GAE70407"/>
        <property type="gene ID" value="JCM18909_3725"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="369"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GAE70407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="477" mass="52179" checksum="03C35DD56DE0A528" modified="2014-03-19" version="1">MSVPNILATRYASAAMRSIWTPENKIRAERRLWLTVMEAQADLGVSFGGDDPEQVLADYQAVLDDVDLDSIAEREAITRHDVKARIEEFNALAGHEHIHKGMTSRDLTENIEQMQVLESLRLVRDKMVATLNQLSRLAAQFSDQAIAGRSHNVAAQVTTLGKRFATAIDEMLVAWDHVNELIERYPARGIKGPMGTAQDMLDLLGGDESKLDDLECRVADHLGFNQVLTSTGQIYPRSLDFEVISTLVQVLSGPSNLATSIRLMAGNELVTEGFKPGQVGSSAMPHKMNARSCERVNGFLVVLRGYLTMATGLAGVQWNEGDVSCSVVRRVALPDSFYAIDGAFETFLTILGDFGAFPAVIEAELERYLPFLTTTKVLMACVRAGVGREDAHEAIKEHAVAVALDMRETGRTGNDLFARLAADPRIPLTKEQLRGLVSSPLDLTGGAQDQVEALCAKVEDIVREYPEAANYLPGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPK1</accession>
    <name>W4TPK1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70139">
        <property type="protein sequence ID" value="GAE70139"/>
        <property type="gene ID" value="JCM18909_3435"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12767" checksum="DF973BE855C62EEC" modified="2014-03-19" version="1">MNLRLALNGLPLPTAARASYIDVVAPVLARQRELRRELPELLCPADRRIQAFIDRYLGEDSSVHPRLPDTTLTLDEPGLTRPLTTRRRRRFQFRPCLELPSGQRRPTQSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPN7</accession>
    <name>W4TPN7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70482">
        <property type="protein sequence ID" value="GAE70482"/>
        <property type="gene ID" value="JCM18909_3809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6757" checksum="A74A465FB4CA5B1E" modified="2014-03-19" version="1">MFVNRHPRLLTAGITFRDLVISGIDELPGLGEERYGTDFVTTWGGVANTARIAASWVLGSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPV4</accession>
    <name>W4TPV4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoaspartyl aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_3568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000040">
        <property type="protein sequence ID" value="GAE70264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70264">
        <property type="protein sequence ID" value="GAE70264"/>
        <property type="gene ID" value="JCM18909_3568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="PTHR10188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="237"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE70264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="321" mass="33426" checksum="FAA6E41C5D715347" modified="2014-03-19" version="1">MDKPLMTSTRNQPYDPVMTSHVVDQPGPTLVIHGGAGNVPSRTGEEAEKFRRSLRQAFAAGQRALDVSACDAVIAAVTAMEDDPLFNAGRGGVLTANGTVETDAAVMTGDGHAGAVCCSRHARNPIQLAHKVLTDSPHVLLCDPPERVCQDWGLEIAPPEYFVTQARREQLEQVLARRQHAPKHGTVGAVARDRYGHLAAATSTGGIVASSQGRIGDSPVIGAGTFARDGVVAVSCTGDGEAFLQGVVAHEVDAQMRLAGQPVDRAALGALTDEVSSRLTGHAPATGGLIAVDSCEQLVVCHVSASMLAAWPDHGEVLTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ17</accession>
    <name>W4TQ17_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobyric acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000042">
        <property type="protein sequence ID" value="GAE70324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70324">
        <property type="protein sequence ID" value="GAE70324"/>
        <property type="gene ID" value="JCM18909_3638"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE70324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7493" checksum="74B81DEF6BF242AA" modified="2014-03-19" version="1">MTGILVAGTSSDAGKSLVVTALCRVARRRGVDVVPFKAQNMSNNSMVCADGSEIGRASTSRPLQPGSHQHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ59</accession>
    <name>W4TQ59_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000064">
        <property type="protein sequence ID" value="GAE70677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70677">
        <property type="protein sequence ID" value="GAE70677"/>
        <property type="gene ID" value="JCM18909_4053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6225" checksum="645FA4CFA884C31F" modified="2014-03-19" version="1">MSDRMSQVLGWLALALVLGACVVVMVAMRTTGWVQAGIMALALGVVITVLGVYNRRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQT3</accession>
    <name>W4TQT3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000055">
        <property type="protein sequence ID" value="GAE70594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70594">
        <property type="protein sequence ID" value="GAE70594"/>
        <property type="gene ID" value="JCM18909_3944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5716" checksum="CC419D365E2D0AA3" modified="2014-03-19" version="1">MNLIVLGSRFQAGYASSLRMVGLSDCAARRQAPMDVSKSRQKLRIIYTKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQU1</accession>
    <name>W4TQU1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_3955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000056">
        <property type="protein sequence ID" value="GAE70604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70604">
        <property type="protein sequence ID" value="GAE70604"/>
        <property type="gene ID" value="JCM18909_3955"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019108">
        <property type="entry name" value="Caa3_assmbl_CtaG-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09678">
        <property type="entry name" value="Caa3_CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE70604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="186" mass="21305" checksum="680455401B3C4C5F" modified="2014-03-19" version="1">MVIYLASTGLWEYSSMQFSWHMLVHMTFNMLVPALLVLGAPITLLRRVLRSGDQINDGFNGPHDCLMATLEWRPTKILFGPFAAWIVFIASFYVVYFTPIFGYLMRYHWGHQWMLLHFLMAGFMLFEYVIGLDDLPVSLPHIGRLGFVITAMPFHSFFAVITMNAHQIIGKDFLRGTIYSVGSQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TR39</accession>
    <name>W4TR39_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_4098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000080">
        <property type="protein sequence ID" value="GAE70714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70714">
        <property type="protein sequence ID" value="GAE70714"/>
        <property type="gene ID" value="JCM18909_4098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7472" checksum="27F0F4D69FEB6D0E" modified="2014-03-19" version="1">MREASYAGEHLRSPGSWVLVVPDVLINPQAPHSRKADWVSVRLLQDRVDRPSDSLPVVLSLACESQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>W4TDY1</accession>
    <name>W4TDY1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc uptake regulation protein ZUR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66976">
        <property type="protein sequence ID" value="GAE66976"/>
        <property type="gene ID" value="JCM18909_4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE66976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="144" mass="16172" checksum="11EC161B83E55C66" modified="2014-03-19" version="1">MVENRRRTTKQRLAIRALFDDESFFLTAQQVHDQLRDRGDQVGLATVYRNLQTMAEDGELDAIRAEDGEMTYRRCSSAHHHHLVCRNCGKAVEIGPEKILEDWARDIAAKYEFSETGHELELFGICSECSAVRTGSVISDAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEN0</accession>
    <name>W4TEN0_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="7">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyQS</name>
        <name evidence="9" type="ORF">JCM18909_5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="7"/>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE66977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE66977">
        <property type="protein sequence ID" value="GAE66977"/>
        <property type="gene ID" value="JCM18909_5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="8"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="324"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="207"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="328"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE66977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="463" mass="52765" checksum="BE65D9950A14AB23" modified="2014-03-19" version="1">MASTSTLDNVINLCKRRGFVFPCGEIYGGTRAAWDYGPFGVELKENIKRQWWRAMVTRRDDVVGLDSSVILPREVWVASGHVGVFNDPLTECLSCHKRMRADHLQEGHAAKHGIADPDSISLEEVNCPNCGNKGQWTEPRDFNMMLKTYLGPVEDKSGLHYLRPETAQGIFVNFQNVLTSARKKPPFGIAQTGKSFRNEITPGNFIFRTREFEQMEMEFFVEPGTDEEWHQYWIDARTAWYTDLGINPDNLRHYEHPKEKLSHYSKRTVDVEYKFGFTGSDWGELEGIANRTDFDLGNHSRHSGKDLSYYDQANNKRYLPYVIEPAAGLTRSLMAFMVDAYTEDEAPNAKGGVDKRTVLKLDPRLSPVKAAVLPLSRNSDLSPKARDLAACLREHWNVDFDDAQAIGKRYRRQDEIGTPFCITVDFDSLEDDAVTIRERDTMAQQRVSIDKVEEYLGGRLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TEQ4</accession>
    <name>W4TEQ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sialic acid utilization regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67276">
        <property type="protein sequence ID" value="GAE67276"/>
        <property type="gene ID" value="JCM18909_322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20084" checksum="62245429BEC1101B" modified="2014-03-19" version="1">MITKIAFHEARTIENTARAVDADELEAVASAISIAPRTALFGVGSSGLVASDLSEKLERIGLVCQHHQDTHMQLVHAALCKRPCVALGISFSGNTQEVVEALTVAHKHGATTVAMTGLPDSPVGRLADHVLVTSARETQVRAGAMSSRMAQLAVVDFLFARVAQLCMDDLETLLSSTRTAVSTHRKSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF09</accession>
    <name>W4TF09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator of pyridoxine metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">JCM18909_33</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67003">
        <property type="protein sequence ID" value="GAE67003"/>
        <property type="gene ID" value="JCM18909_33"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE67003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="288" mass="31071" checksum="04352BE64DD08AB4" modified="2014-03-19" version="1">MRPDLVVDLPLHLPDDPRPLPVRICEEVRGLIMDGVLAPGDHLPSTRVLSAQLRVSRGTVVASYEQLEAEGYLVAAAGSGTQVNPDLRGVHRRSATTASVLRPQRHRGIDLTPGAPDTAGLANSAWRSAWRRSCVNPSRITDPLGSPHLRHEIAEHLRQMRSLLTDPRQVVVTGGARAGLAELIQVLCDGSRRLTIGVESPGYPSLRRVPTALGHRIAGLPTDDQGLDPASLPTGRDRKRLDAVLITPSHQYRGAGHCQQAAEQPSSSGRRWPHAGLSKTTSILNCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TF54</accession>
    <name>W4TF54_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67157">
        <property type="protein sequence ID" value="GAE67157"/>
        <property type="gene ID" value="JCM18909_198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20543" checksum="1E4533896D81B26E" modified="2014-03-19" version="1">MAAPVLDLVLPALPETSANLIGQRLRQRMSHLHPHIESTVSFVPAVGQYKAPRIKLSWRELVLVPVNATHLHSNPPQVVQHAAELRRSHPDLAIKVARPTGPAPVLLNLVDARLRLAAHRVHAQELDSLVLSSPDGGDLRGAAMLSKLTRLWSQHHHLPVRIAPIVVGLLRSRRSSPACDRKGAAISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFE5</accession>
    <name>W4TFE5_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67690">
        <property type="protein sequence ID" value="GAE67690"/>
        <property type="gene ID" value="JCM18909_768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="315" mass="34059" checksum="9B2EACD11CD8AAD0" modified="2014-03-19" version="1">MTWKGYAQDLRNHPGREDGLAGSPGTLANTPDKNPKVMKTNAQDEAKGITSYTGAQADDQYVAKHFPFVWFHSIIGNDGTGKDALTHPTDGGVPSDTKHIVNLDDHSRGLVNDLAKPADQVPAFNWITPNNCSDAHDATCKGNNLSGLFDAHGHPDYSKPLTTPPKNHTGGLYAADLWLRYYIPLIEKSAAFKDGGLIDITFDEANPPFANLSFNNATDNTDVAKAARRHELYNYSPQTVKDLAPGYQKYAPGTFPGATTTARNYLKADLAGRTSTARTSTGSPPARTPPWPPTSTATSSSPDRRKRLYHPASVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFH2</accession>
    <name>W4TFH2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67183">
        <property type="protein sequence ID" value="GAE67183"/>
        <property type="gene ID" value="JCM18909_225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="42" mass="5013" checksum="AB9C0E79755831C5" modified="2014-03-19" version="1">MLGWAFAVWGTGLYWWAFFLYLVQTIRIVRTLPRISSRGEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TFI8</accession>
    <name>W4TFI8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YciO family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000001">
        <property type="protein sequence ID" value="GAE67198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67198">
        <property type="protein sequence ID" value="GAE67198"/>
        <property type="gene ID" value="JCM18909_241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE67198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5627" checksum="3B2BC5EC954CF1AA" modified="2014-03-19" version="1">MVDGWQVQDEIGDQLDAVLDSGDCGVEPTTVVDFTSGEAVITRRGVGDPSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-04-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG12</accession>
    <name>W4TG12_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transhydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67452">
        <property type="protein sequence ID" value="GAE67452"/>
        <property type="gene ID" value="JCM18909_513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008746">
        <property type="term" value="F:NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008142">
        <property type="entry name" value="AlaDH/PNT_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000203">
        <property type="entry name" value="NADP_transhydrogenase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00836">
        <property type="entry name" value="ALADH_PNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="4">
        <location>
            <begin position="60"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="3">
        <location>
            <begin position="202"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE67452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="473" mass="49725" checksum="827F6201D4FC9CB7" modified="2014-03-19" version="1">MGLIRATESEQLISFEDAVGHCKWGAPFFSLHIAPNLGKRATPVSWTRTFGRKVTIMIIGIPRESLPGENRVAATPTTVPALLKLGYEVVVEAGAGEHAAQPDRAYEEAGVRIVEPGEAWQADLVLAVNEPTDDQISLMRAGAVLVTFLHPRQDLALTEKLAAAGVTGLSMDMVPRISRAQSMDALSSMANISGYRAVVEAAFAYGRTFGGQVTAAGKVPPAKVFVIGTGVAGLAALGAANSMGAEVYATDVRPETAEQVQSMGATFLHVRTGDSDQGVSSDGYAKETSDDYNARAAELYMEQAGKDDVIITTAAIPGKPSPKLITAEMVSAMKPGSVIVDLAALGGGNCELTRPGESYVTDNGVTIIGYTDLPSRLPGQASQLYGTNLVNLLKLATPEKNGELVLNFDDEVIRTMTVCHEGQVAFPPPPVQVAAAPKPVAKAEIASAPAIPEKKSRARGRRPSASSQCCRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TG84</accession>
    <name>W4TG84_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heme ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67542">
        <property type="protein sequence ID" value="GAE67542"/>
        <property type="gene ID" value="JCM18909_608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18594" checksum="E0B245ED7722F87C" modified="2014-03-19" version="1">MTQHHEQAFAFTVREVVGMGRAPYPVGDDEPLIEQCMQQVAVDGLAQRDVTTLSGGELARTVFARVLAQTTQVVLLDEPTAALDLRHQEAIMACALRLARQGSLVLVVLHDLSLAARYSDRVVVFHHGRLYAEGTPHDVLTPSLVRQVYHHDVVVIDHPVTGRPLVVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGA0</accession>
    <name>W4TGA0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_494</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000002">
        <property type="protein sequence ID" value="GAE67433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67433">
        <property type="protein sequence ID" value="GAE67433"/>
        <property type="gene ID" value="JCM18909_494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE67433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="255" mass="26012" checksum="E44DD64DFAF67C4A" modified="2014-03-19" version="1">MDFSTIINFDSFSQLVPLVRGSIIAGIILGVLAGLIGPIIHARDLAFAIHGTSELSFAGAAVALFFGASVTKGAVVGSLVAALILGLLGVKAAERNASIGIMLPFGMGIGVLFLGLYKGRSSNKFGLLTGQIVAVDTTELSTLVVVAIFVAVCLGIIWRPLFFASVDPEAAKARGVPMRFLSIVFMLLLGLTTAMAVQLVGALLVLSLLITPTAAAAKVTAHPLAMSLLSIVFATVSAVGGIMLSLGPGLPISPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TGG6</accession>
    <name>W4TGG6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Branched-chain amino acid transport system carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">JCM18909_968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">JCM 18909</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the transport system for branched-chain amino acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67876">
        <property type="protein sequence ID" value="GAE67876"/>
        <property type="gene ID" value="JCM18909_968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GAE67876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="280" mass="29901" checksum="DEA66D5A479E47E6" modified="2014-03-19" version="1">MAIISSAVSGCSSVHGMTSRVSPHYATIFTCLLYLTIGPAFAIPRTATVSYEVGVAPFIQDHGPALPIFTIVFFTMTLVAALKPGKLMDWVGRYLTPLFLALLAILIVATLIHPMPTVANRPPQPPYDHQPFMHGFLDGYNTMDALASLAFAIVIIEAINQRGSTGRRDVTHITIRAGLVATIPLTLVYVSLAWLGRTSALVVPNAANGGVVLAGVSRHYYGTAGQVLIAAIVLVACLKTAIGLVVACAEIFRRMFRRGRRCEAGSSSSAWRQPSSPTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH09</accession>
    <name>W4TH09_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000003">
        <property type="protein sequence ID" value="GAE67718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67718">
        <property type="protein sequence ID" value="GAE67718"/>
        <property type="gene ID" value="JCM18909_797"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14639" checksum="FB22FF9A70744169" modified="2014-03-19" version="1">MDVNWDALRCRAHELTKRAYVPYSHFPVGAVGLAEDGRVVVGCNVENAGYGVTLCAECGLISDLVAGGGGHLLAFCCVDAMGETIMPCGRCRQLLWEHGGPTMLIDTPAGVQTMTEVLPQAFGVDNLDRVTNQQEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH10</accession>
    <name>W4TH10_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000004">
        <property type="protein sequence ID" value="GAE67822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE67822">
        <property type="protein sequence ID" value="GAE67822"/>
        <property type="gene ID" value="JCM18909_908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_3" evidence="1">
        <location>
            <begin position="144"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE67822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="312" mass="33569" checksum="DA241D2087E4A19C" modified="2014-03-19" version="1">MARQNGAEGTLPQATEEILTAATELGYWRTDPNVARLHVLVSDIGRTGYWATLSGVLSAALDLGVETSLHVLAGSPERCRSTMQCALDARADGVVVLEFDSPSVALLPGLPVDLPVAIAGGRPEGGEPWSRAWIDDHAGAVMATEYLADLGHRRIAYVGVPPAGHPDPRCAGWREVLATRGLPPLEPLATGWSVETGMHVARAVRAHRVTAVLCGNDDVALGLLTGLDRLGLRVPEDVSVVGMDDHPIRWPLGQRSRRCGLISLPWEKLRPVLPLERNPAEESRFLRPSSFGPQRVLRWMAAPILDVGMMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>W4TH26</accession>
    <name>W4TH26_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_1199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68086">
        <property type="protein sequence ID" value="GAE68086"/>
        <property type="gene ID" value="JCM18909_1199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE68086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="341" mass="36113" checksum="6C45F0A8922D9FD2" modified="2014-03-19" version="1">MARAAGVSTATVSRALRNDARITEATRVAVQAAATRLAYIPRHAARSLSQTFTHTLGLVLPHIDGPYYADLLVGFETEAGIAGYSVIVTLAAPGSDATQTVRTLASQADGIAFLARSGASNELIASIGHTVPVVTSARPQVGRHGAYFVRNSSMAVEMTQHLIDHGRRHIAFVGLPEPGFDLGHRHSGYLKAMHAAGLEPTTHEVFPTEAAGISFARALMTDKIRHDALVCGNDELALAIMHELQDGGVHVGDELAITGWDDTVAARYVRPGLTTVSQPARQLGGLVAQRLVQRIAGTDLTDEVAALPAHMVHRTSCGCCNEGARTTPSSTPTPHNIEEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>W4THQ1</accession>
    <name>W4THQ1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000005">
        <property type="protein sequence ID" value="GAE68042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68042">
        <property type="protein sequence ID" value="GAE68042"/>
        <property type="gene ID" value="JCM18909_1149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dhC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14213" checksum="8F4B99BCCD68D1EE" modified="2014-03-19" version="1">MAGNFVDDGSGETDEEQKLRNESRKILHIPDLLVAGTCVRIPVYSGHGLVVHAEFRESLSPEKATELLTQAPGVKVVDVPDPRSAAGIDPSLVGRIRADQSAPAGKGLVFFCAADNLRKGAALNAVQLAELVAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TI81</accession>
    <name>W4TI81_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exodeoxyribonuclease V beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000009">
        <property type="protein sequence ID" value="GAE68466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68466">
        <property type="protein sequence ID" value="GAE68466"/>
        <property type="gene ID" value="JCM18909_1605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="41" mass="4876" checksum="D9FE3AED54706CA3" modified="2014-03-19" version="1">MFEVWLIVQYPTVTCLTEFFTWHPRPELIEAISERLGGLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIF7</accession>
    <name>W4TIF7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68750">
        <property type="protein sequence ID" value="GAE68750"/>
        <property type="gene ID" value="JCM18909_1906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6869" checksum="500FCE2FF03FCEB0" modified="2014-03-19" version="1">MTWNESSDEVLDFSREPGFRCIVNFGAEKVAVDADAVIASSIPLEAQGKTVSVGRDQAVWLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG4</accession>
    <name>W4TIG4_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aminopeptidase N</fullName>
            <ecNumber evidence="4">3.4.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">JCM18909_1917</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M01.009"/>
    <dbReference type="EnsemblBacteria" id="GAE68760">
        <property type="protein sequence ID" value="GAE68760"/>
        <property type="gene ID" value="JCM18909_1917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="13">
        <location>
            <begin position="109"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="12">
        <location>
            <begin position="242"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GAE68760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="381" mass="42592" checksum="C79B6A29D7900C8A" modified="2014-03-19" version="1">MSSVNITREEAQQRSQVITTHSSKVLVDLSGRDPNGDPLGEPTETFVSSSTIQFSSTGGQNHLDLIADGVYAADLDGTPLDPAAFSHNRFPFTTEPGTHEITVTALCRYSHSGEGLHRFVDPADGKVYLYTQFEIADARRMYADFEQPDQKMTFELQVIAPTGWTIVSNSPTPEPVEGPWEGMSRWSFEPTLPISTYLTALVAGEYHVDHGTIHTASGEIDADILCRQSITEYLDADRIRTTTQRGFEVYEAEFGYPYPFGKYTQSFVPEFNAGAMENAACITHRDDLLFRSRVTSAAYENRDNTILHELAHMWFGDLVTMKWWDDLWLNESFAEWASHHCQEKIVEKHGGIDRGFPSPTSARPGVTPRTSCRPPTPSQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TIG8</accession>
    <name>W4TIG8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic axial filament protein CafA and Ribonuclease G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000011">
        <property type="protein sequence ID" value="GAE68571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68571">
        <property type="protein sequence ID" value="GAE68571"/>
        <property type="gene ID" value="JCM18909_1718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20358" checksum="87F11C55892211FC" modified="2014-03-19" version="1">MLDETDNTTPNSSGNSTAGIPAPRRRRAASRPAGAPAPVETMRAPVAITAAGSGGSIVTSDVEASDLPRPPMGRRRKATSTPHDVKTDVPKVVSLEPTPEEPESADTRTEEKPRRTRRGASETAPSTEAERGTSQRRRATRRRSSRTAEKIEETTEATTATNKGDGADDDPINVALTEAKARPVTTRLRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ00</accession>
    <name>W4TJ00_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galacto-N-biose-/lacto-N-biose I ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68507">
        <property type="protein sequence ID" value="GAE68507"/>
        <property type="gene ID" value="JCM18909_1650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004848780" evidence="2">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="102" mass="10572" checksum="2E7EDD6C76C51AD8" modified="2014-03-19" version="1">MITRRTRRMASVAAIVAGTLVLGACGSSSGGSGSPGKAASQSAAASGPVTIKYLHRLPDGEGMTKVADIVKKSGTRSILTSRLKPRNSRARPMSSCPSWRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ16</accession>
    <name>W4TJ16_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsP</name>
        <name evidence="4" type="ORF">JCM18909_1273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000006">
        <property type="protein sequence ID" value="GAE68154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68154">
        <property type="protein sequence ID" value="GAE68154"/>
        <property type="gene ID" value="JCM18909_1273"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GAE68154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8247" checksum="ED8DBFD3582C5F49" modified="2014-03-19" version="1">MATKIRLKRLGKIRTPHYRVVVMDSRAKRDGRAIEEIGQYHPRPIRRSSRSTLSACSTGSASVPSRLKLLLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ44</accession>
    <name>W4TJ44_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68811">
        <property type="protein sequence ID" value="GAE68811"/>
        <property type="gene ID" value="JCM18909_1974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="150" mass="15749" checksum="F68383D1D510C511" modified="2014-03-19" version="1">MPLLTWYHGADRGELSARTLLTWVTKSVYLLDSEGVEPGGVSRLSVCGAHPGHWTSCVWLLASWWAGLRVDLTGQEEAALEVIGPDVSPDVLIQCSLAPLATACETLVSGAIDNADVLAAPDDLVAARPAAANAVWLTGARNGPENNFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJ93</accession>
    <name>W4TJ93_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-amino-4-ketopentanoate thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68473">
        <property type="protein sequence ID" value="GAE68473"/>
        <property type="gene ID" value="JCM18909_1614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="38" mass="4461" checksum="FE7C39C502AFD94A" modified="2014-03-19" version="1">MSNSYDDVMARRSDIMRRALALDYDSFQHGDLVFDYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJI7</accession>
    <name>W4TJI7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_2308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69120">
        <property type="protein sequence ID" value="GAE69120"/>
        <property type="gene ID" value="JCM18909_2308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="6">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="238" mass="27404" checksum="356B694E9B18FF75" modified="2014-03-19" version="1">MALFDKAWAQRTGGQFVLRIEDTDRTRLVAGSEDQIYQTLEWLGLSPDESPLVGGPYEPYKQSERLDTYKPLVEKLIESGHAYRCWCSQERLKQLREERAAAKSPETGYDRMCLGMSKEERAKLPGFTETPVVRMLIPEDVDLEFDDLIRGTVRAPRPDDQVILKADGFPTYHMAVVVDDHLMGIDTVVRGEEWISSTPKHLLLYKWLGWEAPRFAHMPLLRNTDRSKISKRKNRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJK3</accession>
    <name>W4TJK3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_1458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000008">
        <property type="protein sequence ID" value="GAE68329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68329">
        <property type="protein sequence ID" value="GAE68329"/>
        <property type="gene ID" value="JCM18909_1458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE68329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13062" checksum="1DFE4840DF97C9B1" modified="2014-03-19" version="1">MMASSIKRVFPVWKRAGIGLPGIYSEQALPGRKDAVEISVSPDMLDAAFAIARLATATGHCFCPPASTSPIEVIQYEGRIDAWLREVARASGMEVVGAGVDAEDVTWPNGCAPRTPPPRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJM7</accession>
    <name>W4TJM7_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe-S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_1897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000013">
        <property type="protein sequence ID" value="GAE68742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68742">
        <property type="protein sequence ID" value="GAE68742"/>
        <property type="gene ID" value="JCM18909_1897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="43"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="373" mass="40168" checksum="20A9BD3F60DC8B24" modified="2014-03-19" version="1">MTAITDILQDFRSTLRGLDASALEVLDDSRLARALYSSDASIYRVVPTAIAHPRSTDELSTLVTAASQVGLPITARGAGTTCAGNAVGTGLVIDTSAHLNRILSLDPQARTAVVEPGVVQDWLQHAGARHRLRFGPDPSTSTRCTIGGMIGNNACGPRALGYGRTGDNLVDVDLLTADGHVTTLRRGDLTVPFAQRLVDMADANLATIRTEFATFSRQVSGYSMEWLLPERGRNFPAFIAGTEATLGIVTRATVQLVREAAYAVTVALGYPSMPEAADAVTALLPFSPVAVRVRTPDRRRGFACRTPGAGLAARRRLDVRRAARGRRDRGSFTSPEAGCRQRMPGRMDRLRSWPGYGSVEDPRGWCRARRSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>W4TJN8</accession>
    <name>W4TJN8_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dolichol-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_2361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000018">
        <property type="protein sequence ID" value="GAE69170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69170">
        <property type="protein sequence ID" value="GAE69170"/>
        <property type="gene ID" value="JCM18909_2361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="405" mass="43836" checksum="73F4D613F596BC02" modified="2014-03-19" version="1">MTTLRIAQLANFVGPVSGGMKVAIDALGKGYVAAGHERILVIPGPKDRITESESGITVEIAAPRVSAGYRMIATPWRALDILDRFRPTSIESSDKWTLTPAAGWASRRGIGSVLFSHERLDDMLTMWVRRQFGVAAAVGALNRRLSKSFDVVVVTSDYSAGEFADTGARLVKVPLGVDLETFNPNKRQPGLPTPRPDDILRLCYVGRMSHEKSPQLAVAAALELHRRGVPLRLDMYGVGPDTDAMKQQAGDAPVFFNGFVAGRDEVARRFAAADISMSVCPAETFGLASLEALACGTPVVTANRGGAHEIVDVTSGEAGSPDAVGLADATQRLAARLGPELRDAARHRAEQFTWDASVETMLMIHSEIAARPDAKPYWKQRLVNRRNARRDTQDPLAPTDDSQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK32</accession>
    <name>W4TK32_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_2058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000015">
        <property type="protein sequence ID" value="GAE68887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68887">
        <property type="protein sequence ID" value="GAE68887"/>
        <property type="gene ID" value="JCM18909_2058"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE68887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11321" checksum="906E65743E621CDD" modified="2014-03-19" version="1">MALNTGHEGGCGTVHANGVAEVPARLEALAALDGLSREAASAQITAALHTVIHVERGERGRRVAEIGVFVDVEGRAVVLPAVRWDADGVMTLGDGAERLSQLLGMEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK38</accession>
    <name>W4TK38_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_1631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000010">
        <property type="protein sequence ID" value="GAE68489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68489">
        <property type="protein sequence ID" value="GAE68489"/>
        <property type="gene ID" value="JCM18909_1631"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006522">
        <property type="term" value="P:alanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17591" checksum="E1050F4D283FB17C" modified="2014-03-19" version="1">MGRIGLRPEYLAELTAAADRAKGVEVEGVFTHLPISDVPEGAEFTRREIDTFMTAVSLVETHRGPFPLVHLANSGAILGHDLGKTSMVRAGIVGYGYDPNPHADHADLHPALSWISHVTFVKTISVGDTIGYGRTWTASETTKNRHRPSRLRRWTVPGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TK99</accession>
    <name>W4TK99_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000014">
        <property type="protein sequence ID" value="GAE68858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE68858">
        <property type="protein sequence ID" value="GAE68858"/>
        <property type="gene ID" value="JCM18909_2025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE68858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="228" mass="25714" checksum="243AAEEEDA87074E" modified="2014-03-19" version="1">MEAVRRSIDIGLNSLDGETFDRVVELLRDDSRPLCLVAAATGHALLDYFRLLVRYYRRDVILLDSTDRMVHQLIDLPDNAILLASVFDRHSRMVESVLRLFHQRNMTTVLLTNRSSTPMRRYADHVLLVSSESSTAFRSRACYLILLESLVAALAPADYEVERFRVETMQGLFDELGVFYYSVMCSGMWPNIPIADRRFGPALSTAARMRGMAFLLGEAVAGALEVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TKQ2</accession>
    <name>W4TKQ2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA-specific adenosine-34 deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_2750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000024">
        <property type="protein sequence ID" value="GAE69525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69525">
        <property type="protein sequence ID" value="GAE69525"/>
        <property type="gene ID" value="JCM18909_2750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE69525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7172" checksum="E56C865DA1A14D71" modified="2014-03-19" version="1">MLRGSRGWFFGAFDPKAGAVSSLFDVMRDPRLPHRPKVVAGVMAEESSALLREFFDGRRACTVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TL31</accession>
    <name>W4TL31_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaerobic glycerol-3-phosphate dehydrogenase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000020">
        <property type="protein sequence ID" value="GAE69242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69242">
        <property type="protein sequence ID" value="GAE69242"/>
        <property type="gene ID" value="JCM18909_2437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="149"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28175" checksum="2C19137B5F7E8264" modified="2014-03-19" version="1">MDAPPQARQASYQGPIVFFQGCAGGYFETETSKKSIEVLEHLGYEVLVPKQGCCGLAKQSNGLFEGATKDILSLCDKIISLGKGLTVVSSSGSCVGMMKHEAHEIMGVDDPRLHDVSVRSLDFSEFLMDEYRNGELDTSQFRPIDITVPYHQPCQVKSQGMGFPAVQLMELIPGVKVLESNEPCCGIAGTYGLKAERYKVAQKIGAGVFKHMQDHNEGVGVCDTETCRWQISKSSGVKIVHPVWLLHHSLGLSNNLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLD1</accession>
    <name>W4TLD1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_2536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000021">
        <property type="protein sequence ID" value="GAE69332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69332">
        <property type="protein sequence ID" value="GAE69332"/>
        <property type="gene ID" value="JCM18909_2536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="22136" checksum="47DB302E7D895F06" modified="2014-03-19" version="1">MSQLGLDRRIGGRMGRHAWPRGVFFDPGPWAIMSAIVVWLLTIYRVTPCVQHNVAKVVDPYQRQCYSDIPTLYRSSGMGHGGSLFANPDIAQTPLVTVLMAFCRRVVWAFGAEVSPKATDQQVLDAANAYWGVAQIVLFVAFLAIAISVMLLGRGSDTNLPVDDKAARPRRGGDLGMFSGWCCARRCTSPVSSTFPWFRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLJ0</accession>
    <name>W4TLJ0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADPH-dependent mycothiol reductase Mtr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">JCM18909_2205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">JCM 18909</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000016">
        <property type="protein sequence ID" value="GAE69024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69024">
        <property type="protein sequence ID" value="GAE69024"/>
        <property type="gene ID" value="JCM18909_2205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="7">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GAE69024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16296" checksum="66F4DEFC5F373A70" modified="2014-03-19" version="1">MEHYDIVVIGSGSGNTILDEDFADRRAAIIDSGAFGGTCLNVGCIPTKMFVLPADFASSPSEAVRVGVDLQFRGASFASIRDRIFGRIDSISKAGLSYRQGLDNIDVYTGEAAFIDAHTLEVGGRCITADQIVLAAGSRPRVPDVPGLDDPSMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TLL9</accession>
    <name>W4TLL9_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000030">
        <property type="protein sequence ID" value="GAE69880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69880">
        <property type="protein sequence ID" value="GAE69880"/>
        <property type="gene ID" value="JCM18909_3145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="39"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE69880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21477" checksum="A1ABA939975D936E" modified="2014-03-19" version="1">MEILDEILGAVDVFELRPRIGMASSALAHRIPESEKVGNIVVSAAWAVVGRWREAYDEQDVARAGSLLERMGLVGMVDRTWGTLSEGECKRVEIARALMTDPELLLLDEPAAGLDLAGREQLVEVLSAIFTDPDAPASVLVTHHLEEIPAGVTHALVMAEGHVAAAGLVETTLTSEVLSGAFGMPLTVSHVDGRWNARAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMD0</accession>
    <name>W4TMD0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-glucuronidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000036">
        <property type="protein sequence ID" value="GAE70140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70140">
        <property type="protein sequence ID" value="GAE70140"/>
        <property type="gene ID" value="JCM18909_3436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="1">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7131" checksum="3C86540A6F17D07D" modified="2014-03-19" version="1">MNERVFDSFDAVVGEHIWNFADFATTSGTMRVGGNRKGIFTRDRQPKSAAFHLRMRWRGVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TMJ3</accession>
    <name>W4TMJ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamyl-Q-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">JCM18909_3183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000031">
        <property type="protein sequence ID" value="GAE69916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69916">
        <property type="protein sequence ID" value="GAE69916"/>
        <property type="gene ID" value="JCM18909_3183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="6">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GAE69916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8413" checksum="D6EF39FF1132A5AE" modified="2014-03-19" version="1">MTDFATTHSGLRHAAGRFAPSPTSALHLGNLRTALAAWLLARSTGRRFVVRIEDLDRARVAAAGKKLPRLNYATWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-08-12" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN68</accession>
    <name>W4TN68_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TsaC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000032">
        <property type="protein sequence ID" value="GAE69967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69967">
        <property type="protein sequence ID" value="GAE69967"/>
        <property type="gene ID" value="JCM18909_3242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE69967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="153" mass="15785" checksum="C47EE1334C1D4394" modified="2014-03-19" version="1">MDETDQTMVNTDELAGPVAEEKSTVSGIEPRGDAAAEDSGISPFILDVANPDSCEDALEQAADAIADGECIVLPTDTVYGIGADALNALAVQRLLNAKERGRDMPPPVLVSDSVALPAMPAHTGGGKDSCREVLAWGSHSCFACSGVSWHGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>W4TN98</accession>
    <name>W4TN98_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">JCM18909_3280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">JCM 18909</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000033">
        <property type="protein sequence ID" value="GAE70002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70002">
        <property type="protein sequence ID" value="GAE70002"/>
        <property type="gene ID" value="JCM18909_3280"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GAE70002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="169" mass="17620" checksum="FC296BD00E4F45A0" modified="2014-03-19" version="1">MIFIGIWLQAVPFLLLGTIISSTLTAFLKPQALARFLPHQTALAVVVAGLAGIALPACECASVPTTKSLVRAGVPTAAALTFMVASPAINPVVIAATAVAYTVNPRMAVARFIAGLLAAVLIGLGWIWLGRPLRGLMTAPRDLPARGPADCMTTNRAPYPQWPRPSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNA6</accession>
    <name>W4TNA6_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">JCM18909_3519</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">JCM 18909</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="BAVM01000039">
        <property type="protein sequence ID" value="GAE70221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70221">
        <property type="protein sequence ID" value="GAE70221"/>
        <property type="gene ID" value="JCM18909_3519"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GAE70221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="282" mass="30387" checksum="AFCEF6DED3AD0386" modified="2014-03-19" version="1">MKYSWADPQKVHDAVEAGIAGGARRVCMVASGHGPSRRDVERVNGMVRSLKADHPDVEVCVCLGFVDDEKAASIKEAGADAYNHNANTARSHYGEICSTHSYEDRMDTVEVLKRNGLSPCSGVIVGMGETDEEFVDVIFDLREHGVDSVPVNFLLPFEGTPLAGGAQHITPQWCLKRLAMVRFVHPDSEVRAAAGREQHIRTMQPLALEIVNSIFLGDYLTSEGAAGAADLQMIEDGGFVPEGADGQPMVHTDVNSHRSANLPVNAVPIRHRGIGTEVPANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNG1</accession>
    <name>W4TNG1_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PTS EIIB type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">JCM18909_3362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000034">
        <property type="protein sequence ID" value="GAE70077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70077">
        <property type="protein sequence ID" value="GAE70077"/>
        <property type="gene ID" value="JCM18909_3362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIB type-2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GAE70077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="103" mass="10986" checksum="7B06425F8DEAAAE8" modified="2014-03-19" version="1">MNTMASEVKVLVACGSGIATSTVAQEKVKEILRDAKIPAKITKGTVGQLPVLQDCVDVIMLTTRYGKPLNKPVIQVFGLISGINEDAVAEEIISTCRDVLNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNP1</accession>
    <name>W4TNP1_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70157">
        <property type="protein sequence ID" value="GAE70157"/>
        <property type="gene ID" value="JCM18909_3453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7749" checksum="93934E9209DD71FA" modified="2014-03-19" version="1">MAFFKQSRITVKGSEHLGELGAGQQFESQEEAEAWLSETWPELQDAGINDVTLMKDDDVVYGPMELSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>W4TNQ3</accession>
    <name>W4TNQ3_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">JCM18909_3095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000029">
        <property type="protein sequence ID" value="GAE69839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE69839">
        <property type="protein sequence ID" value="GAE69839"/>
        <property type="gene ID" value="JCM18909_3095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GAE69839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="252" mass="26425" checksum="9E0FA63330CFF532" modified="2014-03-19" version="1">MQRLFRQKMIISSLGTSPTSVDTLVELTGASPATIRRDLTDLEGHGQLRKVHGGAVGVNLRGTPMPYSLRSAENADGKAAIAQLVSRLVTDDMSVIIDNGSTMVAVAQALQERPITALCLSLRAALPLGEGGVATVSTPDGTLMPESLRYEAASCLRALGEFRADVAIVGTCSASPAMGLTVTTHQDAQVKRAILASSARVVLAATGDKLSRTSSFRFGDIEDIDDLVTTRDAPQVTLGAFRVAGSRVYVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP21</accession>
    <name>W4TP21_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000041">
        <property type="protein sequence ID" value="GAE70287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70287">
        <property type="protein sequence ID" value="GAE70287"/>
        <property type="gene ID" value="JCM18909_3595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15383" checksum="4A621481CF5F31AE" modified="2014-03-19" version="1">MGHVPTPDRSLTDEARERIANRYPSPRRAPWVVLIIVLAVILIGWTVWTGLYHADQPIRASLHGYQAVSDSRVDVTIKLHRPNPSVAGSCTLVATGADHVRVGETTVTFPASSSQDETIRASVKTFSRAVTADLEKCGPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>W4TP78</accession>
    <name>W4TP78_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000038">
        <property type="protein sequence ID" value="GAE70213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70213">
        <property type="protein sequence ID" value="GAE70213"/>
        <property type="gene ID" value="JCM18909_3511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="489" mass="54462" checksum="231289DAFBF77930" modified="2014-03-19" version="1">MSLTTFFDTSMHGFGRYLDFGRVTISFAGLDESTVSGYERGLDLRHAVAHTCFDAGGVRHQRSAFASREADVIVLRYSASAPFGCTVRLESAQGVLSRVAGDTSVVFDGVLGNGLRYCASLIVLECDGRSIADGDRIVVEDATTLALVLDAGTDYALSAAAGWRGVNPRPVVDERICSAMALGWGRLHDAHVTNFSAVMDRCRLRWGRPVPELDAQPTDERLRRYRDGAADVGLEQLAIVLGRYLLVSSSRAEGLPANLQGLWNDSNDPVWGSDYHTNINVQMNYWGAEVTGLSEEHMALLNFVEEVAVPSRSATQAMCGPDVPGWTARTSQSPLGGNGWQPNTVASAWYAHHVYEHWAFTRDDEWLRTRGLPMLAEICRFWEHQLVERDDGMIIAPAGWSPEHGPREDGVTYDQQIVWDLFTNLLECSRALGVEDDLYYRVERLRDRMAPNQVGCWGQLQEWQDDRDDPTELHRHTSHLFAVYPGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPD0</accession>
    <name>W4TPD0_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000054">
        <property type="protein sequence ID" value="GAE70576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70576">
        <property type="protein sequence ID" value="GAE70576"/>
        <property type="gene ID" value="JCM18909_3926"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24010" checksum="E65043B3ABB849F7" modified="2014-03-19" version="1">MSATHTHRYWAMMRPMHQIVWIAAVVTIAVAGWPALTRILPEPATATPDKIAYRDTYSLRSLIAVCAAAAVTMIAATMWAPAPTWPTWALLATIGAWVAVIDAITTWIPAALAWTGWAGWIGAVAVTALSDQTAATRAVIATTIIFAAWMIAWLISRGGFGFSDVRITPLWAAPVAATGIDTIHATVIAGLTLIALYALIDRFRHHTTRFLPWRPACAAAPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TPM7</accession>
    <name>W4TPM7_CUTAC</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_binding_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000037">
        <property type="protein sequence ID" value="GAE70174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70174">
        <property type="protein sequence ID" value="GAE70174"/>
        <property type="gene ID" value="JCM18909_3471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11692" checksum="9A243064550B85EF" modified="2014-03-19" version="1">MISTVDDVLAAVEALPAGTVVTYSDVAQLVGTSPRRVGMIMACEGQEVDWWRVTTVRGTLPEHLMAHARQHWDEEGLGGGTTMLRDHAPDPAEWERNWQQLRGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQ29</accession>
    <name>W4TQ29_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulator putative TetR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_3815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000048">
        <property type="protein sequence ID" value="GAE70488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70488">
        <property type="protein sequence ID" value="GAE70488"/>
        <property type="gene ID" value="JCM18909_3815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16719" checksum="FEA9B55BE6683D32" modified="2014-03-19" version="1">MRGAGFTRGAFYSNFTSKDDLCTTVLRRYAEKNLATLGSSLNFPNDGHEALRDRIHDIIALFASTVGSDPLTAMAILEITIEQHGIHDCVRPTGRSETLSLLPCATWSSRLCVNTPPPPPSRSPTSSRSPKPSSIFGCWRQWRQDVRPTSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQE2</accession>
    <name>W4TQE2_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">JCM18909_3769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000046">
        <property type="protein sequence ID" value="GAE70444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70444">
        <property type="protein sequence ID" value="GAE70444"/>
        <property type="gene ID" value="JCM18909_3769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GAE70444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12037" checksum="BE7DD221A35ACA18" modified="2014-03-19" version="1">MSDYPEADWELVYLSGLPDQQLAHLATPSTLDVSSLVPVGLGSALEFRSGWTARLPCSWDVVSCGRSSSRRFEARIGNTHSARDDSRIAGRCSSPSHRTFRISDGLAAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2019-12-11" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>W4TQJ4</accession>
    <name>W4TQJ4_CUTAC</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">JCM18909_4054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cutibacterium acnes JCM 18909</name>
        <dbReference type="NCBI Taxonomy" id="1302241"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Propionibacteriales</taxon>
            <taxon>Propionibacteriaceae</taxon>
            <taxon>Cutibacterium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2014-01" db="EMBL/GenBank/DDBJ databases">
            <title>NBRP : Genome information of microbial organism related human and environment.</title>
            <authorList>
                <person name="Hattori M."/>
                <person name="Oshima K."/>
                <person name="Inaba H."/>
                <person name="Suda W."/>
                <person name="Sakamoto M."/>
                <person name="Iino T."/>
                <person name="Kitahara M."/>
                <person name="Iida T."/>
                <person name="Kudo T."/>
                <person name="Itoh T."/>
                <person name="Ohkuma M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">JCM 18909</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BAVM01000065">
        <property type="protein sequence ID" value="GAE70678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="GAE70678">
        <property type="protein sequence ID" value="GAE70678"/>
        <property type="gene ID" value="JCM18909_4054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000019082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GAE70678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000019082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11063" checksum="BCCF90DB8BDF7585" modified="2014-03-19" version="1">MGPHIAFAGGVAAAIYARYRGHLGDGKDVNTPLAGIGHPDILCVGAAFGIFGYLCQIGIANIPWFGKHTDPVALTVLLSGLLARLIFGGVPGKGLFHGSLHNPELFS</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>